#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19320	uniprotkb:Q15942	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-444225|ensembl:ENSP00000324422|ensembl:ENSP00000494798|uniprotkb:Q6I9S4|uniprotkb:A4D2G6|uniprotkb:B4DQX7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:zyx_human(display_long)|uniprotkb:Zyxin-2(gene name synonym)|uniprotkb:ZYX(gene name)|psi-mi:ZYX(display_short)	psi-mi:"MI:0096"(pull down)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189871|imex:IM-17358-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000159840(gene)|ensembl:ENSG00000285443(gene)|ensembl:ENST00000322764(transcript)|ensembl:ENST00000646695(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001781(Zinc finger, LIM-type)|go:"GO:0043149"(stress fiber assembly)|refseq:NP_001010972.1|refseq:NP_003452.1	-	-	-	figure legend:suppl fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2014/10/16	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4UC6NVZHDUrTy4sPhz7e7RpPwho9606	intact-crc:D4DA2FE50B0F0C31|rigid:xSH88c257D5lfzQ4qKmOZ1MDqd0	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19320	uniprotkb:P05556	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189871|imex:IM-17358-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:suppl fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2014/10/16	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:D4DA2FE50B0F0C31|rigid:xSH88c257D5lfzQ4qKmOZ1MDqd0	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19320	uniprotkb:Q9Y490	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189871|imex:IM-17358-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:suppl fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2014/10/16	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	intact-crc:D4DA2FE50B0F0C31|rigid:xSH88c257D5lfzQ4qKmOZ1MDqd0	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19320	uniprotkb:P27694	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-621389|ensembl:ENSP00000254719|uniprotkb:Q59ES9|uniprotkb:A8K0Y9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rfa1_human(display_long)|uniprotkb:Replication factor A protein 1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:RPA1(gene name)|psi-mi:RPA1(display_short)|uniprotkb:REPA1(gene name synonym)|uniprotkb:RPA70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000132383(gene)|ensembl:ENST00000254719(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016605"(PML body)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|go:"GO:0006268"(DNA unwinding involved in DNA replication)|mint:P27694|rcsb pdb:1EWI|rcsb pdb:1FGU|rcsb pdb:1JMC|rcsb pdb:1L1O|rcsb pdb:2B29|rcsb pdb:2B3G|rcsb pdb:4IJH|rcsb pdb:4IJL|rcsb pdb:4IPC|rcsb pdb:4IPD|rcsb pdb:4IPG|rcsb pdb:4IPH|rcsb pdb:4LUO|rcsb pdb:4LUV|rcsb pdb:4LUZ|rcsb pdb:4LW1|rcsb pdb:4LWC|rcsb pdb:4NB3|rcsb pdb:4O0A|rcsb pdb:4R4C|rcsb pdb:4R4I|rcsb pdb:4R4O|rcsb pdb:4R4Q|rcsb pdb:4R4T|rcsb pdb:5E7N|rcsb pdb:5EAY|rcsb pdb:5N85|rcsb pdb:5N8A|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-3108214|refseq:NP_002936.1|dip:DIP-24189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DRZpMUlGyS0Qa5XFEtx71k0iPig9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35249	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-476655|uniprotkb:Q6FHX7|ensembl:ENSP00000296273|ensembl:ENSP00000376272|uniprotkb:D3DNV2|uniprotkb:B4DM41	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rfc4_human(display_long)|uniprotkb:Activator 1 subunit 4(gene name synonym)|uniprotkb:Replication factor C 37 kDa subunit(gene name synonym)|uniprotkb:Activator 1 37 kDa subunit(gene name synonym)|uniprotkb:RFC4(gene name)|psi-mi:RFC4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002907.1|refseq:NP_853551.1|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000163918(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|ensembl:ENST00000296273(transcript)|ensembl:ENST00000392481(transcript)|mint:P35249|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|reactome:R-HSA-176187|dip:DIP-24267N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zn+V998ZRpYIdHmG87ExC6LFc0w9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6P2Q9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I0ot8b3pvieXRI66omFm145sGVA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14011	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-538850|uniprotkb:B4E2X2|intact:EBI-10980353|uniprotkb:B3KT17|ensembl:ENSP00000322887|ensembl:ENSP00000465779|ensembl:ENSP00000466110|ensembl:ENSP00000466207|ensembl:ENSP00000468788	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cirbp_human(display_long)|uniprotkb:Glycine-rich RNA-binding protein CIRP(gene name synonym)|uniprotkb:A18 hnRNP(gene name synonym)|uniprotkb:CIRBP(gene name)|psi-mi:CIRBP(display_short)|uniprotkb:A18HNRNP(gene name synonym)|uniprotkb:CIRP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001271.1|refseq:XP_006722700.1|refseq:NP_001287744.1|refseq:NP_001287758.1|ensembl:ENSG00000099622(gene)|ensembl:ENST00000320936(transcript)|ensembl:ENST00000585630(transcript)|ensembl:ENST00000586472(transcript)|ensembl:ENST00000588030(transcript)|ensembl:ENST00000588090(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0009409"(response to cold)|go:"GO:0009411"(response to UV)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030371"(translation repressor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:Q14011|rcsb pdb:1X5S|rcsb pdb:5TBX	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nm6/8k5Pw1AnoXsSw9cazJkL49U9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192387	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000016193E|ipi:IPI00456898	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs12-like(display_short)|psi-mi:EBI-6192387(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.|comment:"Maps to obsolete UniProt_AC (A6NCP0)"	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ef6hwOole2ed/kmvG2tkefUpV+A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00040897|uniparc:UPI000013DB3E	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd2-like(display_short)|psi-mi:EBI-6192393(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0gMx01VsbQ6zzaL726ZE+OfqtX49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192381	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00786982|uniparc:UPI0000DD81BA	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:a9ln06-like(display_short)|psi-mi:EBI-6192381(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:It6ePqwtc+lreAAkOHfFSBhsW489606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192360	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI0000D6259C|ipi:IPI00744503	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg2-like(display_short)|psi-mi:EBI-6192360(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:L9FDFHlcKLLIb2AuVWClY2e7vhs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000059D477|ipi:IPI00641706|ipi:IPI00643158	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6-like(display_short)|psi-mi:EBI-6192365(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wy4rGlQIvXakPLyF0bFYzhvZW/49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000059D477|ipi:IPI00641706|ipi:IPI00643158	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6-like(display_short)|psi-mi:EBI-6192365(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wy4rGlQIvXakPLyF0bFYzhvZW/49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62805	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302023|ensembl:ENSP00000244537|ensembl:ENSP00000347168|ensembl:ENSP00000350767|ensembl:ENSP00000366974|ensembl:ENSP00000366956|ensembl:ENSP00000462667|ensembl:ENSP00000367034|ensembl:ENSP00000478519|ensembl:ENSP00000478786|ensembl:ENSP00000443017|ensembl:ENSP00000462355|ensembl:ENSP00000479106|ensembl:ENSP00000479461|uniprotkb:A2VCL0|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6DRA9|uniprotkb:Q6FGB8|uniprotkb:Q6NWP7|ensembl:ENSP00000479794|ensembl:ENSP00000480960|ensembl:ENSP00000481343|ensembl:ENSP00000481486|ensembl:ENSP00000481507|ensembl:ENSP00000482412|ensembl:ENSP00000484789|ensembl:ENSP00000489319|ensembl:ENSP00000489567	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h4_human(display_long)|uniprotkb:H4-16(gene name)|psi-mi:H4-16(display_short)|uniprotkb:H4C1(gene name)|psi-mi:H4C1(display_short)|uniprotkb:H4C11(gene name)|psi-mi:H4C11(display_short)|uniprotkb:H4C12(gene name)|psi-mi:H4C12(display_short)|uniprotkb:H4C13(gene name)|psi-mi:H4C13(display_short)|uniprotkb:H4C14(gene name)|psi-mi:H4C14(display_short)|uniprotkb:H4C15(gene name)|psi-mi:H4C15(display_short)|uniprotkb:H4C2(gene name)|psi-mi:H4C2(display_short)|uniprotkb:H4C3(gene name)|psi-mi:H4C3(display_short)|uniprotkb:H4C4(gene name)|psi-mi:H4C4(display_short)|uniprotkb:H4C5(gene name)|psi-mi:H4C5(display_short)|uniprotkb:H4C6(gene name)|psi-mi:H4C6(display_short)|uniprotkb:H4C8(gene name)|psi-mi:H4C8(display_short)|uniprotkb:H4C9(gene name)|psi-mi:H4C9(display_short)|uniprotkb:H4/A(gene name synonym)|uniprotkb:H4/B(gene name synonym)|uniprotkb:H4/C(gene name synonym)|uniprotkb:H4/D(gene name synonym)|uniprotkb:H4/E(gene name synonym)|uniprotkb:H4/G(gene name synonym)|uniprotkb:H4/H(gene name synonym)|uniprotkb:H4/I(gene name synonym)|uniprotkb:H4/J(gene name synonym)|uniprotkb:H4/K(gene name synonym)|uniprotkb:H4/M(gene name synonym)|uniprotkb:H4/N(gene name synonym)|uniprotkb:H4/O(gene name synonym)|uniprotkb:H4F2(gene name synonym)|uniprotkb:H4FA(gene name synonym)|uniprotkb:H4FB(gene name synonym)|uniprotkb:H4FC(gene name synonym)|uniprotkb:H4FD(gene name synonym)|uniprotkb:H4FE(gene name synonym)|uniprotkb:H4FG(gene name synonym)|uniprotkb:H4FH(gene name synonym)|uniprotkb:H4FI(gene name synonym)|uniprotkb:H4FJ(gene name synonym)|uniprotkb:H4FK(gene name synonym)|uniprotkb:H4FM(gene name synonym)|uniprotkb:H4FN(gene name synonym)|uniprotkb:H4FO(gene name synonym)|uniprotkb:HIST1H4A(gene name synonym)|uniprotkb:HIST1H4B(gene name synonym)|uniprotkb:HIST1H4C(gene name synonym)|uniprotkb:HIST1H4D(gene name synonym)|uniprotkb:HIST1H4E(gene name synonym)|uniprotkb:HIST1H4F(gene name synonym)|uniprotkb:HIST1H4H(gene name synonym)|uniprotkb:HIST1H4I(gene name synonym)|uniprotkb:HIST1H4J(gene name synonym)|uniprotkb:HIST1H4K(gene name synonym)|uniprotkb:HIST1H4L(gene name synonym)|uniprotkb:HIST2H4(gene name synonym)|uniprotkb:HIST2H4A(gene name synonym)|uniprotkb:HIST2H4B(gene name synonym)|uniprotkb:HIST4H4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000197061(gene)|ensembl:ENSG00000276180(gene)|ensembl:ENSG00000197238(gene)|ensembl:ENSG00000276966(gene)|ensembl:ENSG00000277157(gene)|ensembl:ENSG00000270276(gene)|ensembl:ENSG00000197837(gene)|ensembl:ENSG00000270882(gene)|ensembl:ENSG00000278637(gene)|ensembl:ENSG00000273542(gene)|ensembl:ENSG00000274618(gene)|ensembl:ENSG00000278705(gene)|ensembl:ENSG00000275126(gene)|ensembl:ENSG00000158406(gene)|dip:DIP-33079N|ensembl:ENST00000244537(transcript)|ensembl:ENST00000355057(transcript)|ensembl:ENST00000358064(transcript)|ensembl:ENST00000377727(transcript)|ensembl:ENST00000377745(transcript)|ensembl:ENST00000377803(transcript)|ensembl:ENST00000539745(transcript)|ensembl:ENST00000578186(transcript)|ensembl:ENST00000579512(transcript)|ensembl:ENST00000611927(transcript)|ensembl:ENST00000612061(transcript)|ensembl:ENST00000613412(transcript)|ensembl:ENST00000614247(transcript)|ensembl:ENST00000614272(transcript)|ensembl:ENST00000615164(transcript)|ensembl:ENST00000615353(transcript)|ensembl:ENST00000617569(transcript)|ensembl:ENST00000618193(transcript)|ensembl:ENST00000618305(transcript)|ensembl:ENST00000621520(transcript)|ensembl:ENST00000634560(transcript)|ensembl:ENST00000634956(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0005576"(extracellular region)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AYW|rcsb pdb:3AZJ|rcsb pdb:3AZK|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:3F9W|rcsb pdb:3F9X|rcsb pdb:3F9Y|rcsb pdb:3F9Z|rcsb pdb:3IJ1|rcsb pdb:3JPX|rcsb pdb:3NQJ|rcsb pdb:3NQU|rcsb pdb:3O36|rcsb pdb:3QBY|rcsb pdb:3QZS|rcsb pdb:3QZT|rcsb pdb:3QZV|rcsb pdb:3R45|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3WTP|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:4GQB|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:4M38|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4QUT|rcsb pdb:4QUU|rcsb pdb:4QYD|rcsb pdb:4U9W|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4YY6|rcsb pdb:4YYD|rcsb pdb:4YYG|rcsb pdb:4YYH|rcsb pdb:4YYI|rcsb pdb:4YYJ|rcsb pdb:4YYK|rcsb pdb:4YYM|rcsb pdb:4YYN|rcsb pdb:4Z2M|rcsb pdb:4Z5T|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5AY8|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B2J|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5B40|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5CPI|interpro:IPR019809|interpro:IPR035425|mint:P62805|rcsb pdb:1ZKK|rcsb pdb:2BQZ|rcsb pdb:2CV5|rcsb pdb:2IG0|rcsb pdb:2KWN|rcsb pdb:2KWO|rcsb pdb:2LVM|rcsb pdb:2QQS|rcsb pdb:2RJE|rcsb pdb:2RNY|interpro:IPR009072(Histone-fold)|rcsb pdb:2RS9|rcsb pdb:3A6N|rcsb pdb:3AFA|rcsb pdb:3AN2|rcsb pdb:3AV1|rcsb pdb:3AV2|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5GXQ|rcsb pdb:5JA4|rcsb pdb:5JRG|rcsb pdb:5KDM|rcsb pdb:5TEG|rcsb pdb:5X7X|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5YE3|rcsb pdb:5YE4|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:5ZBX|rcsb pdb:5ZGC|rcsb pdb:5CPJ|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:5CPK|rcsb pdb:6A5P|rcsb pdb:5FA5|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6ACP|rcsb pdb:6BUZ|rcsb pdb:6C0W|rcsb pdb:6E0C|rcsb pdb:6E0P|rcsb pdb:6FML|rcsb pdb:6HKT|rcsb pdb:6HTS|rcsb pdb:6INQ|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6KXV|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:5FFW|rcsb pdb:5FWE|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MLC|rcsb pdb:6MUO|rcsb pdb:6MUP|rcsb pdb:6O1D|rcsb pdb:6R0C|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|refseq:NP_001029249.1|refseq:NP_003486.1|refseq:NP_003529.1|refseq:NP_003530.1|refseq:NP_003531.1|refseq:NP_003532.1|refseq:NP_003533.1|refseq:NP_003534.1|refseq:NP_003535.1|refseq:NP_003536.1|refseq:NP_003537.1|refseq:NP_003539.1|rcsb pdb:6R92|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6RNY|rcsb pdb:6RXS|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2K|rcsb pdb:6V92|rcsb pdb:6VO5|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6YOV|rcsb pdb:7A08|rcsb pdb:7BWD|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:7CCR|rcsb pdb:7CIZ|rcsb pdb:7CJ0|rcsb pdb:7D1Z|rcsb pdb:7D20|rcsb pdb:7DBP|rcsb pdb:7JO9|rcsb pdb:7JOA|rcsb pdb:7JZV|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7LMK|rcsb pdb:7LMM|rcsb pdb:7LYC|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|refseq:NP_068803.1|refseq:NP_778224.1|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050760|uniprotkb:Q53RW7|uniprotkb:Q6URK5|uniprotkb:D3DPF4|ensembl:ENSP00000376309|ensembl:ENSP00000416340|ensembl:ENSP00000503593|ensembl:ENSP00000504135|ensembl:ENSP00000504152	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa3_human(display_long)|uniprotkb:HNRPA3(gene name synonym)|uniprotkb:HNRNPA3(gene name)|psi-mi:HNRNPA3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_919223.1|refseq:NP_001317178.1|ensembl:ENSG00000170144(gene)|ensembl:ENST00000392524(transcript)|ensembl:ENST00000435711(transcript)|ensembl:ENST00000676629(transcript)|ensembl:ENST00000678111(transcript)|ensembl:ENST00000679159(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0051028"(mRNA transport)|go:"GO:0051033"(RNA transmembrane transporter activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034513|interpro:IPR034516|interpro:IPR035979|mint:P51991|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bbg0nIdhEHomcwtgZhT2yHy7+nU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35658	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q1WWK5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190162	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q1wwk5_human(display_long)|uniprotkb:SEPT9(gene name)|psi-mi:SEPT9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005525"(GTP binding)|interpro:IPR027417|interpro:IPR030645	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:80HBLhdKw7dQlez8rvVWnMBquJM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43243	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352602|ensembl:ENSP00000378284|ensembl:ENSP00000482895|uniprotkb:Q9UHW0|uniprotkb:Q9UQ27|uniprotkb:D3DQC3|uniprotkb:B7ZAV5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:matr3_human(display_long)|uniprotkb:KIAA0723(gene name synonym)|uniprotkb:MATR3(gene name)|psi-mi:MATR3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000015479(gene)|ensembl:ENST00000394805(transcript)|ensembl:ENST00000618441(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:P43243|refseq:NP_001181883.1|refseq:NP_001181884.1|refseq:NP_061322.2|refseq:NP_954659.1|refseq:NP_001181885.1|refseq:NP_001269207.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3UZlyCZHgdr1SBgUctv9Ev7XBSQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61289	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08648	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y520	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2685847|uniprotkb:Q05DM8|uniprotkb:Q9HA05|uniprotkb:Q9UF29|uniprotkb:Q9NSM8|uniprotkb:Q9H2N2|uniprotkb:Q9NXL3|uniprotkb:Q6PD54|uniprotkb:Q49A39|uniprotkb:Q9UPQ6|intact:EBI-2824421	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prc2c_human(display_long)|uniprotkb:BAT2D1(gene name synonym)|uniprotkb:KIAA1096(gene name synonym)|uniprotkb:XTP2(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HBV X-transactivated gene 2 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 2(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:PRRC2C(gene name)|psi-mi:PRRC2C(display_short)|uniprotkb:BAT2L2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055987.2|refseq:XP_006711301.1|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|ensembl:ENST00000338920|ensembl:ENSP00000343629|ensembl:ENSG00000117523|ensembl:ENST00000426496|ensembl:ENSP00000410219|ensembl:ENST00000647382|ensembl:ENSP00000495867|refseq:XP_005245074.1|dip:DIP-47285N|mint:Q9Y520	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qecMuJHnm8n95OFpT+m+i9JbBoo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54886	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1210304|ensembl:ENSP00000360268|uniprotkb:O95952|uniprotkb:Q5T566|uniprotkb:Q9UM72|uniprotkb:Q3KQU2|uniprotkb:B2R5Q4|uniprotkb:B7Z350|uniprotkb:B7Z5X8|uniprotkb:B7ZLP1|uniprotkb:Q5T567|uniprotkb:D3DR44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p5cs_human(display_long)|uniprotkb:ALDH18A1(gene name)|psi-mi:ALDH18A1(display_short)|uniprotkb:P5CS(gene name synonym)|uniprotkb:PYCS(gene name synonym)|uniprotkb:GSAS(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 18 member A1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000059573(gene)|ensembl:ENST00000371224(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004349"(glutamate 5-kinase activity)|go:"GO:0004350"(glutamate-5-semialdehyde dehydrogenase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0006592"(ornithine biosynthetic process)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000965(Gamma-glutamyl phosphate reductase GPR)|interpro:IPR001048(Aspartate/glutamate/uridylate kinase)|refseq:NP_001017423.1|refseq:NP_002851.2|refseq:NP_001310341.1|refseq:NP_001310342.1|refseq:NP_001310343.1|refseq:NP_001310344.1|refseq:NP_001310345.1|refseq:NP_001310348.1|interpro:IPR001057(Glutamate 5-kinase)|interpro:IPR005715(Glutamate 5-kinase, ProB-related)|interpro:IPR005766(delta l-pyrroline-5-carboxylate synthetase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR019797|interpro:IPR020593|interpro:IPR036393|interpro:IPR041744|mint:P54886|rcsb pdb:2H5G|reactome:R-HSA-8964539	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NLYlqQhi3HebSXYBxkkSmKplRCM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08727	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742756|uniprotkb:Q5XG83|uniprotkb:Q6NW33|uniprotkb:Q7L5M9|uniprotkb:Q96A53|uniprotkb:Q96FV1|uniprotkb:Q9BYF9|uniprotkb:Q9P1Y4|uniprotkb:B2R874|ensembl:ENSP00000355124	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c19_human(display_long)|uniprotkb:Cytokeratin-19(gene name synonym)|uniprotkb:Keratin-19(gene name synonym)|uniprotkb:KRT19(gene name)|psi-mi:KRT19(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002267.2|ensembl:ENSG00000171345(gene)|ensembl:ENST00000361566(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990357"(terminal web)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P08727|reactome:R-HSA-6805567|reactome:R-HSA-6809371|dip:DIP-35655N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fqsG2nghpcmTtI39LiYVLNYuFIA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14671	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-948453|ensembl:ENSP00000257075|uniprotkb:Q5VXY7|uniprotkb:Q9HAN1|intact:EBI-2842591|uniprotkb:E9PCJ0|uniprotkb:Q53HH5|uniprotkb:B4DG92|uniprotkb:A8K6W4|uniprotkb:D3DPN3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pum1_human(display_long)|uniprotkb:PUM1(gene name)|psi-mi:PUM1(display_short)|uniprotkb:KIAA0099(gene name synonym)|uniprotkb:PUMH1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134644(gene)|ensembl:ENST00000257075(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048863"(stem cell differentiation)|interpro:IPR033712|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0061157"(mRNA destabilization)|mint:Q14671|rcsb pdb:1IB2|rcsb pdb:1M8W|rcsb pdb:1M8X|rcsb pdb:1M8Y|rcsb pdb:1M8Z|rcsb pdb:2YJY|rcsb pdb:3BSB|rcsb pdb:3BSX|rcsb pdb:3Q0L|rcsb pdb:3Q0M|rcsb pdb:3Q0N|rcsb pdb:3Q0O|rcsb pdb:3Q0P|rcsb pdb:5YKH|rcsb pdb:5YKI|reactome:R-HSA-432722|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001313(Pumilio RNA-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033133|refseq:NP_001018494.1|refseq:NP_055491.1|dip:DIP-29082N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tGsSgrvQ/Ehnm3UC5IO4CHhCrFs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49327	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356658|uniprotkb:Q4LE83|uniprotkb:Q13479|uniprotkb:Q16702|uniprotkb:Q6P4U5|uniprotkb:Q6SS02|uniprotkb:Q969R1|uniprotkb:Q96C68|uniprotkb:Q96IT0|ensembl:ENSP00000304592	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fas_human(display_long)|uniprotkb:FASN(gene name)|psi-mi:FASN(display_short)|uniprotkb:FAS(gene name synonym)|uniprotkb:Type I fatty acid synthase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004095.4|ensembl:ENSG00000169710(gene)|ensembl:ENST00000306749(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003723"(RNA binding)|go:"GO:0004313"([acyl-carrier-protein] S-acetyltransferase activity)|go:"GO:0004314"([acyl-carrier-protein] S-malonyltransferase activity)|go:"GO:0004315"(3-oxoacyl-[acyl-carrier-protein] synthase activity)|go:"GO:0004316"("3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity")|go:"GO:0004317"(3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0004320"(oleoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0008659"("(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity")|go:"GO:0008693"(3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0016020"(membrane)|go:"GO:0016295"(myristoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0016296"(palmitoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031177"(phosphopantetheine binding)|go:"GO:0042470"(melanosome)|go:"GO:0042587"(glycogen granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0047451"(3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0102131"(obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity)|go:"GO:0102132"(obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity)|interpro:IPR001031(Thioesterase)|interpro:IPR001227(Acyl transferase region)|interpro:IPR006162(Phosphopantetheine attachment site)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011032(GroES-like)|interpro:IPR013149(Alcohol dehydrogenase, zinc-binding)|interpro:IPR013217(Methyltransferase type 12)|interpro:IPR013968(Polyketide synthase, KR)|interpro:IPR014030(Beta-ketoacyl synthase, N-terminal)|interpro:IPR014031(Beta-ketoacyl synthase, C-terminal)|interpro:IPR014043(Acyl transferase)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR016036(Malonyl-CoA ACP transacylase, ACP-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR018201|interpro:IPR020806|interpro:IPR020807|interpro:IPR020841|interpro:IPR020843|interpro:IPR029058|interpro:IPR029063|interpro:IPR032821|interpro:IPR036291|interpro:IPR036736|interpro:IPR042104|mint:P49327|rcsb pdb:1XKT|rcsb pdb:2CG5|rcsb pdb:2JFD|rcsb pdb:2JFK|rcsb pdb:2PX6|rcsb pdb:3HHD|rcsb pdb:3TJM|rcsb pdb:4PIV|rcsb pdb:4W82|rcsb pdb:4W9N|rcsb pdb:4Z49|rcsb pdb:5C37|rcsb pdb:6NNA|reactome:R-HSA-163765|reactome:R-HSA-199220|reactome:R-HSA-2426168|reactome:R-HSA-75105|reactome:R-HSA-9029558|go:"GO:0047117"("enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity")|refseq:XP_011521840.1|dip:DIP-33681N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bQYEH/uQ6l+SPzLBDNCV5yP+yzs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14103	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299674|ensembl:ENSP00000313199|uniprotkb:P07029|uniprotkb:Q01858|uniprotkb:Q14100|uniprotkb:Q14101|uniprotkb:Q14102|uniprotkb:Q4W5A1|uniprotkb:A8K9J2|uniprotkb:Q9UCE8|uniprotkb:Q9UCE9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpd_human(display_long)|uniprotkb:HNRNPD(gene name)|psi-mi:HNRNPD(display_short)|uniprotkb:AUF1(gene name synonym)|uniprotkb:HNRPD(gene name synonym)|uniprotkb:AU-rich element RNA-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000138668(gene)|ensembl:ENST00000313899(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1901355"(response to rapamycin)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1904586"(cellular response to putrescine)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990828"(hepatocyte dedifferentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR035979|mint:Q14103|rcsb pdb:1HD0|rcsb pdb:1HD1|rcsb pdb:1IQT|rcsb pdb:1WTB|rcsb pdb:1X0F|rcsb pdb:2Z5N|rcsb pdb:5IM0|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|reactome:R-HSA-450408|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:NP_001003810.1|refseq:NP_002129.2|refseq:NP_112737.1|refseq:NP_112738.1|dip:DIP-31163N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LrC0nOpN6jGn3WELs5NEOccNPnw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11142	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11021	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P56192	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75608	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052185|uniprotkb:O43202|uniprotkb:Q9UQF9|ensembl:ENSP00000320043	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lypa1_human(display_long)|uniprotkb:Lysophospholipase 1(gene name synonym)|uniprotkb:Lysophospholipase I(gene name synonym)|uniprotkb:LYPLA1(gene name)|psi-mi:LYPLA1(display_short)|uniprotkb:APT1(gene name synonym)|uniprotkb:LPL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006321.1|refseq:NP_001266285.1|refseq:NP_001266286.1|refseq:NP_001266287.1|refseq:NP_001266288.1|refseq:NP_001266289.1|ensembl:ENSG00000120992(gene)|ensembl:ENST00000316963(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0016298"(lipase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003140(Phospholipase/carboxylesterase)|interpro:IPR029058|rcsb pdb:1FJ2|rcsb pdb:5SYM|rcsb pdb:6QGN|go:"GO:0005737"(cytoplasm)|rcsb pdb:6QGO|rcsb pdb:6QGQ|rcsb pdb:6QGS|reactome:R-HSA-203615|reactome:R-HSA-9648002	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y/NsD5HcH2FjnwUrSCBzeevQU+s9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35908	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1247312|uniprotkb:Q4VAQ2|ensembl:ENSP00000310861	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k22e_human(display_long)|uniprotkb:KRT2(gene name)|psi-mi:KRT2(display_short)|uniprotkb:KRT2A(gene name synonym)|uniprotkb:KRT2E(gene name synonym)|uniprotkb:Cytokeratin-2e(gene name synonym)|uniprotkb:Keratin-2e(gene name synonym)|uniprotkb:Type-II keratin Kb2(gene name synonym)|uniprotkb:Keratin-2 epidermis(gene name synonym)|uniprotkb:Epithelial keratin-2e(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000414.2|ensembl:ENSG00000172867(gene)|ensembl:ENST00000309680(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0031424"(keratinization)|go:"GO:0032980"(keratinocyte activation)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P35908|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0051546"(keratinocyte migration)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T7LeB8nkZzNjUb8DWdkxbrl5f789606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36873	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356283|ensembl:ENSP00000335084	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1g_human(display_long)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0004721"(phosphoprotein phosphatase activity)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000335007(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0043197"(dendritic spine)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P36873|rcsb pdb:1IT6|rcsb pdb:1JK7|rcsb pdb:1U32|rcsb pdb:2BCD|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|rcsb pdb:2BDX|rcsb pdb:4UT2|rcsb pdb:4UT3|go:"GO:0046872"(metal ion binding)|rcsb pdb:5INB|go:"GO:0047485"(protein N-terminus binding)|rcsb pdb:5J28|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|reactome:R-HSA-141444|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-9648025|reactome:R-HSA-9660537|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-400253|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-68877|refseq:NP_001231903.1|refseq:NP_002701.1|dip:DIP-749N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SyjV/4d9V8lV/BXub2KESPKvupA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16658	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351076|uniprotkb:Q96IH1|uniprotkb:A6NI89|uniprotkb:Q96IC5|uniprotkb:Q9BRF1|uniprotkb:B2RE97|ensembl:ENSP00000371798	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fscn1_human(display_long)|uniprotkb:FSCN1(gene name)|psi-mi:FSCN1(display_short)|uniprotkb:FAN1(gene name synonym)|uniprotkb:HSN(gene name synonym)|uniprotkb:SNL(gene name synonym)|uniprotkb:Singed-like protein(gene name synonym)|uniprotkb:55 kDa actin-bundling protein(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0044393"(microspike)|go:"GO:0045296"(cadherin binding)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR008999(Actin_cross-linking)|interpro:IPR010431(Fascin)|interpro:IPR022768|interpro:IPR024703|interpro:IPR030146|mint:Q16658|rcsb pdb:1DFC|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030035"(microspike assembly)|rcsb pdb:3LLP|refseq:NP_003079.1|ensembl:ENSG00000075618(gene)|ensembl:ENST00000382361(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008144"(obsolete drug binding)|rcsb pdb:3P53|rcsb pdb:4GOV|rcsb pdb:4GOY|rcsb pdb:4GP3|rcsb pdb:6B0T|rcsb pdb:6I0Z|rcsb pdb:6I10|rcsb pdb:6I11|rcsb pdb:6I12|rcsb pdb:6I13|rcsb pdb:6I14|rcsb pdb:6I15|rcsb pdb:6I16|rcsb pdb:6I17|rcsb pdb:6I18|reactome:R-HSA-6785807|rcsb pdb:4GP0|dip:DIP-33171N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yc9EJDCKGJGGEcEueR/yAY/fxRg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75367	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2868511|uniprotkb:Q7Z5E3|uniprotkb:Q9UP96|uniprotkb:Q9H8P3|uniprotkb:Q503A8|uniprotkb:O75377|uniprotkb:Q96D41|ensembl:ENSP00000423563|ensembl:ENSP00000424971	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h2ay_human(display_long)|uniprotkb:MACROH2A1(gene name)|psi-mi:MACROH2A1(display_short)|uniprotkb:H2AFY(gene name synonym)|uniprotkb:Histone H2A.y(gene name synonym)|uniprotkb:Medulloblastoma antigen MU-MB-50.205(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011542031.1|refseq:XP_011542032.1|refseq:NP_001035248.1|refseq:NP_004884.1|refseq:NP_613075.1|refseq:NP_613258.2|dip:DIP-44283N|ensembl:ENSG00000113648(gene)|ensembl:ENST00000510038(transcript)|ensembl:ENST00000511689(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000182"(rDNA binding)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0007549"(dosage compensation)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902750"(negative regulation of cell cycle G2/M phase transition)|go:"GO:1902882"(regulation of response to oxidative stress)|go:"GO:1902883"(negative regulation of response to oxidative stress)|go:"GO:1902884"(positive regulation of response to oxidative stress)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|go:"GO:1904815"(negative regulation of protein localization to chromosome, telomeric region)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|interpro:IPR032454|interpro:IPR035796|interpro:IPR043472|mint:O75367|rcsb pdb:1U35|rcsb pdb:1ZR3|rcsb pdb:1ZR5|rcsb pdb:2F8N|rcsb pdb:2FXK|rcsb pdb:3HQH|rcsb pdb:3HSV|rcsb pdb:3IID|rcsb pdb:3IIF|rcsb pdb:3IVB|rcsb pdb:5IIT|rcsb pdb:5LNC|interpro:IPR002119(Histone H2A)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0FCoM0/4mTtnc7cPDUleKuZ3HgM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11388	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UNM6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356070|uniprotkb:O75831|uniprotkb:Q9UNV3|uniprotkb:Q53XU2|intact:EBI-1058479|uniprotkb:B3KT15|ensembl:ENSP00000436186	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd13_human(display_long)|uniprotkb:PSMD13(gene name)|psi-mi:PSMD13(display_short)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002808.3|refseq:NP_787128.2|dip:DIP-27576N|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:6MSK|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000185627(gene)|ensembl:ENST00000532097(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007127"(meiosis I)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|mint:Q9UNM6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iOxE62MMeGx+aqsrir/LukJqeho9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NU22	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050480|uniprotkb:O15019|uniprotkb:Q5T794|ensembl:ENSP00000358400|ensembl:ENSP00000486270|ensembl:ENSP00000499843|ensembl:ENSP00000499895	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mdn1_human(display_long)|uniprotkb:MIDAS-containing protein(gene name synonym)|uniprotkb:Dynein-related AAA-ATPase MDN1(gene name synonym)|uniprotkb:MDN1(gene name)|psi-mi:MDN1(display_short)|uniprotkb:KIAA0301(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055426.1|ensembl:ENSG00000112159(gene)|ensembl:ENSG00000288121(gene)|ensembl:ENST00000369393(transcript)|ensembl:ENST00000629399(transcript)|ensembl:ENST00000672983(transcript)|ensembl:ENST00000673332(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR012099(Midasin)|interpro:IPR027417|interpro:IPR036465|interpro:IPR040848|interpro:IPR041190|mint:Q9NU22|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/LVYhffZVpP0pYVM6hLNltoc6pY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NZI8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053892|uniprotkb:C9JT33|ensembl:ENSP00000290341	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2b1_human(display_long)|uniprotkb:ZBP1(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 1(gene name synonym)|uniprotkb:Coding region determinant-binding protein(gene name synonym)|uniprotkb:VICKZ family member 1(gene name synonym)|uniprotkb:IGF2BP1(gene name)|psi-mi:IGF2BP1(display_short)|uniprotkb:Zipcode-binding protein 1(gene name synonym)|uniprotkb:CRDBP(gene name synonym)|uniprotkb:VICKZ1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006537.3|refseq:NP_001153895.1|ensembl:ENSG00000159217(gene)|ensembl:ENST00000290341(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010610"(regulation of mRNA stability involved in response to stress)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022013"(pallium cell proliferation in forebrain)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140059"(dendrite arborization)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034837|interpro:IPR034842|interpro:IPR035979|interpro:IPR036612|mint:Q9NZI8|rcsb pdb:3KRM|rcsb pdb:6QEY|reactome:R-HSA-428359|reactome:R-HSA-5687128|dip:DIP-38139N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Ps/PWWYr0WpYcx3G/AOiQEj+vc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08J23	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642839|intact:EBI-2839052|uniprotkb:A8K529|uniprotkb:B3KP09|uniprotkb:G3V1R4|uniprotkb:Q9BVN4|uniprotkb:Q9H858|uniprotkb:Q9NXD9|uniprotkb:B2RNR4|intact:EBI-2556652|uniprotkb:B4DQW2|ensembl:ENSP00000264670	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nsun2_human(display_long)|uniprotkb:NSUN2(gene name)|psi-mi:NSUN2(display_short)|uniprotkb:SAKI(gene name synonym)|uniprotkb:TRM4(gene name synonym)|uniprotkb:NOL1/NOP2/Sun domain family member 2(gene name synonym)|uniprotkb:tRNA methyltransferase 4 homolog(gene name synonym)|uniprotkb:Substrate of AIM1/Aurora kinase B(gene name synonym)|uniprotkb:Myc-induced SUN domain-containing protein(gene name synonym)|uniprotkb:"mRNA cytosine C(5)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA cytosine C(5)-methyltransferase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001180384.1|refseq:NP_060225.4|dip:DIP-52456N|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0006400"(tRNA modification)|go:"GO:0007286"(spermatid development)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016428"("tRNA (cytosine-5-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0033313"(meiotic cell cycle checkpoint signaling)|go:"GO:0033391"(chromatoid body)|go:"GO:0036416"(tRNA stabilization)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051301"(cell division)|go:"GO:0062152"("mRNA (cytidine-5-)-methyltransferase activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0080009"(mRNA methylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR023267|interpro:IPR023270|interpro:IPR029063|mint:Q08J23|reactome:R-HSA-6782315|ensembl:ENSG00000037474(gene)|ensembl:ENST00000264670(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001510"(RNA methylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k3hK/9cjuy5c4PyDGgCt0LsVtdo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12770	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190187|ensembl:ENSP00000265565|ensembl:ENSP00000497087|uniprotkb:Q8N2E0|uniprotkb:Q8WUA1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:scap_human(display_long)|uniprotkb:SCAP(gene name)|psi-mi:SCAP(display_short)|uniprotkb:KIAA0199(gene name synonym)|uniprotkb:PSEC0227(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114650(gene)|ensembl:ENST00000648151(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032934"(sterol binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|ensembl:ENST00000265565(transcript)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030225|interpro:IPR036322|mint:Q12770|rcsb pdb:6M49|rcsb pdb:7ETW|reactome:R-HSA-1655829|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|refseq:XP_011531803.1|refseq:NP_036367.2|refseq:XP_016861407.1|refseq:XP_016861410.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bhavwLS6XzkZpAoBhCsII97JfpI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08754	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357563|uniprotkb:Q5TZX1|uniprotkb:P17539|ensembl:ENSP00000358867	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gnai3_human(display_long)|uniprotkb:GNAI3(gene name)|psi-mi:GNAI3(display_short)|uniprotkb:"G(i) alpha-3"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006487.1|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|ensembl:ENSG00000065135(gene)|ensembl:ENST00000369851(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:2IHB|rcsb pdb:2ODE|rcsb pdb:2V4Z|rcsb pdb:4G5O|rcsb pdb:4G5R|rcsb pdb:4G5S|rcsb pdb:7E9H|rcsb pdb:7KH0|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9009391|reactome:R-HSA-9660821	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:npLeIXVzrV8y0trCCII5rivIRYQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54819	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61978	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-304185|intact:EBI-28971491|ensembl:ENSP00000317788|ensembl:ENSP00000353552|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q59F98|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62|uniprotkb:Q5T6W4|intact:EBI-3440248|uniprotkb:Q6IBN1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpk_human(display_long)|uniprotkb:HNRNPK(gene name)|psi-mi:HNRNPK(display_short)|uniprotkb:HNRPK(gene name synonym)|uniprotkb:Transformation up-regulated nuclear protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000165119(gene)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000351839(transcript)|ensembl:ENST00000360384(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0002102"(podosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006396"(RNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61978|rcsb pdb:1J5K|rcsb pdb:1KHM|rcsb pdb:1ZZI|rcsb pdb:1ZZJ|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9610379|rcsb pdb:1ZZK|refseq:NP_002131.2|refseq:NP_112552.1|refseq:NP_112553.1|ensembl:ENSP00000317788|ensembl:ENSP00000353552|ensembl:ENST00000376263|ensembl:ENSP00000365439|ensembl:ENST00000376281|ensembl:ENSP00000365458|refseq:NP_001305115.1|refseq:NP_001305116.1|refseq:NP_001305117.1|refseq:XP_016870157.1|refseq:XP_005252017.1|refseq:XP_005252020.1|refseq:XP_005252022.1|dip:DIP-31805N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30043	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2837485|uniprotkb:P53005|uniprotkb:P32078|uniprotkb:Q32LZ2|uniprotkb:B2R5C6|uniprotkb:A6NKD8|ensembl:ENSP00000263368	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:blvrb_human(display_long)|uniprotkb:BLVRB(gene name)|psi-mi:BLVRB(display_short)|uniprotkb:FLR(gene name synonym)|uniprotkb:Biliverdin reductase B(gene name synonym)|uniprotkb:Biliverdin-IX beta-reductase(gene name synonym)|uniprotkb:Green heme-binding protein(gene name synonym)|uniprotkb:NADPH-dependent diaphorase(gene name synonym)|uniprotkb:NADPH-flavin reductase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000704.1|ensembl:ENSG00000090013(gene)|ensembl:ENST00000263368(transcript)|go:"GO:0004074"("biliverdin reductase (NAD(P)+) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042602"("riboflavin reductase (NADPH) activity")|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106276"(biliberdin reductase NAD+ activity)|go:"GO:0106277"("biliverdin reductase (NADP+) activity")|interpro:IPR016040("NAD(P)-binding")|interpro:IPR036291|rcsb pdb:1HDO|rcsb pdb:1HE2|rcsb pdb:1HE3|rcsb pdb:1HE4|rcsb pdb:1HE5|rcsb pdb:5OOG|rcsb pdb:5OOH|rcsb pdb:6OPL|reactome:R-HSA-189483|reactome:R-HSA-9707564	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dAGhnUTdZxBN2cUpArtdmrVdeKw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15020	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75146	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15233	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6M1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1024419|intact:EBI-1059063|intact:EBI-1237206|uniprotkb:A0A4Z0|uniprotkb:B3FTN2|uniprotkb:B3FTN3|uniprotkb:B3FTN4|ensembl:ENSP00000371634	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2b2_human(display_long)|uniprotkb:IGF-II mRNA-binding protein 2(gene name synonym)|uniprotkb:Hepatocellular carcinoma autoantigen p62(gene name synonym)|uniprotkb:VICKZ family member 2(gene name synonym)|uniprotkb:IGF2BP2(gene name)|psi-mi:IGF2BP2(display_short)|uniprotkb:IMP2(gene name synonym)|uniprotkb:VICKZ2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001278801.1|refseq:NP_001278802.1|refseq:NP_001278803.1|refseq:NP_001278804.1|refseq:NP_001007226.1|refseq:NP_006539.3|ensembl:ENSG00000073792(gene)|ensembl:ENST00000382199(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR028743|interpro:IPR034843|interpro:IPR035979|interpro:IPR036612|mint:Q9Y6M1|rcsb pdb:2CQH|rcsb pdb:6ROL|reactome:R-HSA-428359|dip:DIP-35539N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k45UViReMAxCv2cu7+tx+auevQc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15785	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054499|uniprotkb:Q53GH9|uniprotkb:Q6IBN7|uniprotkb:Q9NTZ3|ensembl:ENSP00000361900	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tom34_human(display_long)|uniprotkb:URCC3(gene name synonym)|uniprotkb:Translocase of outer membrane 34 kDa subunit(gene name synonym)|uniprotkb:TOMM34(gene name)|psi-mi:TOMM34(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006800.2|ensembl:ENSG00000025772(gene)|ensembl:ENST00000372813(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:K0J5GQoRwg/7Yz0p2e41R1wQrME9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08779	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356410|uniprotkb:P30654|uniprotkb:Q16402|uniprotkb:Q9UBG8|uniprotkb:A8K488|ensembl:ENSP00000301653	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c16_human(display_long)|uniprotkb:KRT16(gene name)|psi-mi:KRT16(display_short)|uniprotkb:KRT16A(gene name synonym)|uniprotkb:Keratin-16(gene name synonym)|uniprotkb:Cytokeratin-16(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005548.2|ensembl:ENSG00000186832(gene)|ensembl:ENST00000301653(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007568"(aging)|go:"GO:0030216"(keratinocyte differentiation)|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031424"(keratinization)|go:"GO:0042633"(hair cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051546"(keratinocyte migration)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P08779	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NkPTLkWquNNlGYbrXaRkyRmKvmM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01082	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351561|intact:EBI-1642531|uniprotkb:O60837|uniprotkb:Q16057|uniprotkb:Q53R99|uniprotkb:Q59ER3|uniprotkb:Q8IX99|uniprotkb:B2RP63|ensembl:ENSP00000349259	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sptb2_human(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:SPTB2(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 1(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003119.2|refseq:NP_842565.2|ensembl:ENSG00000115306(gene)|ensembl:ENST00000356805(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q01082|rcsb pdb:1AA2|rcsb pdb:1BKR|rcsb pdb:3EDV|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9703465|reactome:R-HSA-373753|refseq:XP_005264574.1|refseq:XP_006712150.1|refseq:XP_016860268.1|refseq:XP_016860269.1|refseq:XP_016860270.1|dip:DIP-33182N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rQJxsoEirg87umLjsEwHcQ0/blQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6B6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4290665|uniprotkb:D3DQA4|uniprotkb:Q567T4|ensembl:ENSP00000385432|ensembl:ENSP00000404997	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sar1b_human(display_long)|uniprotkb:SAR1B(gene name)|psi-mi:SAR1B(display_short)|uniprotkb:SARA2(gene name synonym)|uniprotkb:SARB(gene name synonym)|uniprotkb:GTP-binding protein B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000152700(gene)|ensembl:ENST00000402673(transcript)|ensembl:ENST00000439578(transcript)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0061024"(membrane organization)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006687(GTP-binding protein SAR1)|interpro:IPR006689(ARF/SAR superfamily)|go:"GO:0003400"(regulation of COPII vesicle coating)|interpro:IPR027417|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-5694530|reactome:R-HSA-8963888|reactome:R-HSA-983170|reactome:R-HSA-1655829|refseq:NP_001028675.1|refseq:NP_057187.1|refseq:XP_016865010.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Tq+D9CeccMteZSbthpVFFBuazjY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14697	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31942	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711437|uniprotkb:Q9NPI4|uniprotkb:Q9UFU4|uniprotkb:Q9Y4J5|uniprotkb:Q9BSX1|uniprotkb:Q9NP53|uniprotkb:Q9NP96|uniprotkb:Q9NPA7|ensembl:ENSP00000265866|uniprotkb:A8K682|uniprotkb:B3KRE1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrh3_human(display_long)|uniprotkb:HNRNPH3(gene name)|psi-mi:HNRNPH3(display_short)|uniprotkb:HNRPH3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein 2H9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000096746(gene)|ensembl:ENST00000265866(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034969|interpro:IPR034970|interpro:IPR035979|mint:P31942|refseq:NP_036339.1|refseq:NP_067676.2|refseq:NP_001309363.1|refseq:NP_001309365.1|refseq:NP_001309366.1|refseq:NP_001309367.1|refseq:NP_001309368.1|refseq:NP_001309369.1|refseq:NP_001309370.1|refseq:NP_001309374.1|refseq:NP_001309375.1|refseq:NP_001309376.1|refseq:NP_001309377.1|refseq:NP_001309378.1|refseq:XP_016871657.1|refseq:XP_016871658.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iJGBIhPXnQIIFQmgxWB1WjwVXSY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21333	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23246	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14157	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13765	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712216|ensembl:ENSP00000349212|ensembl:ENSP00000377469|ensembl:ENSP00000446801|ensembl:ENSP00000447821|ensembl:ENSP00000503345|uniprotkb:Q3KQV4|uniprotkb:Q53A18|uniprotkb:Q53G46|uniprotkb:A8MTN7|uniprotkb:B2R4P8|uniprotkb:F8VU71	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:naca_human(display_long)|uniprotkb:Alpha-NAC(gene name synonym)|uniprotkb:NACA(gene name)|psi-mi:NACA(display_short)|uniprotkb:HSD48(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000196531(gene)|ensembl:ENST00000356769(transcript)|ensembl:ENST00000393891(transcript)|ensembl:ENST00000546392(transcript)|ensembl:ENST00000552540(transcript)|ensembl:ENST00000678066(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006412"(translation)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0015031"(protein transport)|go:"GO:0042060"(wound healing)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901227"(negative regulation of transcription from RNA polymerase II promoter involved in heart development)|go:"GO:1901228"(positive regulation of transcription from RNA polymerase II promoter involved in heart development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR016641(Nascent polypeptide-associated complex, alpha subunit)|interpro:IPR038187|interpro:IPR044034|mint:Q13765|rcsb pdb:3LKX|rcsb pdb:3MCB|rcsb pdb:3MCE|go:"GO:0043403"(skeletal muscle tissue regeneration)|refseq:NP_001106672.1|refseq:NP_001307122.1|refseq:NP_001307123.1|refseq:NP_005585.1|refseq:NP_001106673.1|refseq:NP_001106674.2|dip:DIP-43878N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l8QKB8mfSwvDDSSObGLQ7i1LgWo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39656	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358866|uniprotkb:O43244|uniprotkb:Q8NI93|uniprotkb:Q9BUI2|uniprotkb:B2RDQ4|uniprotkb:Q5VWA5|ensembl:ENSP00000399457|uniprotkb:B4DJE3|uniprotkb:B4DLI2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ost48_human(display_long)|uniprotkb:DDOST(gene name)|psi-mi:DDOST(display_short)|uniprotkb:KIAA0115(gene name synonym)|uniprotkb:OST48(gene name synonym)|uniprotkb:OK/SW-cl.45(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005207.2|ensembl:ENSG00000244038(gene)|ensembl:ENST00000415136(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:P39656|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-9694548	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:utOlgvpqe2JHEJHk4gIp8tXwv/I9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02008	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719843|uniprotkb:Q6IBF6|ensembl:ENSP00000252951	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbaz_human(display_long)|uniprotkb:Hemoglobin zeta chain(gene name synonym)|uniprotkb:Zeta-globin(gene name synonym)|uniprotkb:HBAZ(gene name synonym)|uniprotkb:HBZ(gene name)|psi-mi:HBZ(display_short)|uniprotkb:HBZ2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005323.1|ensembl:ENSG00000130656(gene)|ensembl:ENST00000252951(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002340(Haemoglobin, zeta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1JEB|rcsb pdb:3W4U|refseq:XP_005255345.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:K2E42b7eK+PiEY1MPC/IepTjnOI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P2J5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356077|uniprotkb:Q9NSE1|uniprotkb:A2RRR4|uniprotkb:B4DJ10|uniprotkb:Q2TU79|uniprotkb:A7E266|ensembl:ENSP00000377954	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sylc_human(display_long)|uniprotkb:LARS1(gene name)|psi-mi:LARS1(display_short)|uniprotkb:KIAA1352(gene name synonym)|uniprotkb:LARS(gene name synonym)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_064502.9|refseq:NP_001304893.1|refseq:NP_001304894.1|refseq:NP_057544.2|refseq:XP_011535958.1|ensembl:ENSG00000133706(gene)|ensembl:ENST00000394434(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0012505"(endomembrane system)|go:"GO:0016604"(nuclear body)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|mint:Q9P2J5|rcsb pdb:2WFD|rcsb pdb:6KID|rcsb pdb:6KIE|rcsb pdb:6KQY|rcsb pdb:6KR7|rcsb pdb:6LPF|rcsb pdb:6LR6|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nlK4kRCik2LLC3VNl0sryrLLnqA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99714	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-79964|ensembl:ENSP00000168216|uniprotkb:Q8TCV9|uniprotkb:Q96HD5|uniprotkb:Q5H927|uniprotkb:Q6IBS9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hcd2_human(display_long)|uniprotkb:HSD17B10(gene name)|psi-mi:HSD17B10(display_short)|uniprotkb:SCHAD(gene name synonym)|uniprotkb:XH98G2(gene name synonym)|uniprotkb:HADH2(gene name synonym)|uniprotkb:3-hydroxyacyl-CoA dehydrogenase type II(gene name synonym)|uniprotkb:Type II HADH(gene name synonym)|uniprotkb:3-hydroxy-2-methylbutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:Endoplasmic reticulum-associated amyloid beta-peptide-binding protein(gene name synonym)|uniprotkb:Short-chain type dehydrogenase/reductase XH98G2(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 2(gene name synonym)|uniprotkb:2-methyl-3-hydroxybutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:ERAB(gene name synonym)|uniprotkb:MRPP2(gene name synonym)|uniprotkb:SDR5C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 5C member 1(gene name synonym)|uniprotkb:17-beta-estradiol 17-dehydrogenase(gene name synonym)|uniprotkb:"3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))"(gene name synonym)|uniprotkb:"3alpha(or 20beta)-hydroxysteroid dehydrogenase"(gene name synonym)|uniprotkb:7-alpha-hydroxysteroid dehydrogenase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:2O23|reactome:R-HSA-6785470|reactome:R-HSA-6787450|reactome:R-HSA-70895|reactome:R-HSA-8868766|ensembl:ENSG00000072506(gene)|ensembl:ENST00000168216(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008207"(C21-steroid hormone metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008709"(cholate 7-alpha-dehydrogenase activity)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0047015"(3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity)|go:"GO:0047035"("testosterone dehydrogenase (NAD+) activity")|go:"GO:0047044"(androstan-3-alpha,17-beta-diol dehydrogenase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0062173"(brexanolone metabolic process)|go:"GO:0070901"(mitochondrial tRNA methylation)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|go:"GO:0106281"("chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity")|go:"GO:0106282"("isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:0106283"("ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q99714|rcsb pdb:1F67|rcsb pdb:1SO8|rcsb pdb:1U7T|refseq:NP_001032900.1|refseq:NP_004484.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:q6/pRFyay7gQ6bb2rzvKYgfkeaE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53990	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945994|intact:EBI-4324656|uniprotkb:A8KAH5|uniprotkb:Q9BQ81|uniprotkb:Q9BWN2|uniprotkb:Q3SYM4|uniprotkb:J3QLU7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ist1_human(display_long)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Putative MAPK-activating protein PM28(gene name synonym)|uniprotkb:KIAA0174(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055576.2|refseq:NP_001257904.1|refseq:NP_001257906.1|refseq:NP_001257905.1|refseq:NP_001257907.1|mint:P53990|dip:DIP-42546N|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0009838"(abscission)|go:"GO:0015031"(protein transport)|go:"GO:0019076"(viral release from host cell)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046745"(viral capsid secondary envelopment)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:0090543"(Flemming body)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3FRR|rcsb pdb:3FRS|rcsb pdb:3JC1|rcsb pdb:4U7E|rcsb pdb:4U7I|rcsb pdb:4U7Y|rcsb pdb:4WZX|rcsb pdb:6E8G|rcsb pdb:6TZ4|rcsb pdb:6TZ5|rcsb pdb:6TZA|reactome:R-HSA-6798695|reactome:R-HSA-9668328	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RbWwKZ+sftO2x3UkFz8zAxVi2CU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7Z5G4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4403685|ensembl:ENSP00000350378|ensembl:ENSP00000429329|ensembl:ENSP00000429480|uniprotkb:D3DSX9|uniprotkb:Q96EQ4|uniprotkb:Q9P1S0|uniprotkb:Q9Y5U7|uniprotkb:J3KQ24	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:goga7_human(display_long)|uniprotkb:GOLGA7(gene name)|psi-mi:GOLGA7(display_short)|uniprotkb:GCP16(gene name synonym)|uniprotkb:Golgi complex-associated protein of 16 kDa(gene name synonym)|uniprotkb:HDCKB03P(orf name)|uniprotkb:HSPC041(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000147533(gene)|ensembl:ENST00000357743(transcript)|ensembl:ENST00000518270(transcript)|ensembl:ENST00000520817(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002178"(palmitoyltransferase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005795"(Golgi stack)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0018230"(peptidyl-L-cysteine S-palmitoylation)|go:"GO:0031228"(intrinsic component of Golgi membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR019383|reactome:R-HSA-6798695|reactome:R-HSA-9648002|refseq:NP_001002296.1|refseq:NP_057183.2|refseq:NP_001167595.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NV93lzMDdykrGhl0NkCKYso0t+A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13639	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352560|uniprotkb:Q58J86|uniprotkb:B2RMP5|uniprotkb:D6W618|ensembl:ENSP00000307940	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef2_human(display_long)|uniprotkb:EEF2(gene name)|psi-mi:EEF2(display_short)|uniprotkb:EF2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001952.1|ensembl:ENSG00000167658(gene)|ensembl:ENST00000309311(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P13639|rcsb pdb:4V6X|rcsb pdb:6D9J|rcsb pdb:6Z6M|rcsb pdb:6Z6N|reactome:R-HSA-156902|reactome:R-HSA-5336415|reactome:R-HSA-5358493|reactome:R-HSA-6798695|reactome:R-HSA-8876725	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:US1dzGQ5V1oBXVtYeGt5H3HCIr09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22102	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356297|ensembl:ENSP00000371236|ensembl:ENSP00000371253|ensembl:ENSP00000371261|ensembl:ENSP00000459391|ensembl:ENSP00000459532|ensembl:ENSP00000461700|uniprotkb:D3DSF3|uniprotkb:D3DSF4|uniprotkb:O14659|uniprotkb:A8KA32|uniprotkb:A8K945|uniprotkb:Q52M77	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pur2_human(display_long)|uniprotkb:GART(gene name)|psi-mi:GART(display_short)|uniprotkb:PRGS(gene name synonym)|uniprotkb:PGFT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0046084"(adenine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000115(Phosphoribosylglycinamide synthetase)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR004607(Phosphoribosylglycinamide formyltransferase)|interpro:IPR004733(Phosphoribosylformylglycinamidine cyclo-ligase)|interpro:IPR010918(AIR synthase related protein, C-terminal)|ensembl:ENST00000571089(transcript)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|ensembl:ENST00000573055(transcript)|ensembl:ENST00000575273(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0004637"(phosphoribosylamine-glycine ligase activity)|go:"GO:0004641"(phosphoribosylformylglycinamidine cyclo-ligase activity)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|go:"GO:0004644"(phosphoribosylglycinamide formyltransferase activity)|interpro:IPR016185(PreATP-grasp-like fold)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR016188(PurM, N-terminal-like)|ensembl:ENSG00000159131(gene)|ensembl:ENSG00000262473(gene)|ensembl:ENST00000381815(transcript)|ensembl:ENST00000381831(transcript)|ensembl:ENST00000381839(transcript)|interpro:IPR020560|interpro:IPR020561|interpro:IPR020562|interpro:IPR036477|interpro:IPR036676|interpro:IPR036921|interpro:IPR037123|mint:P22102|rcsb pdb:1MEJ|rcsb pdb:1MEN|rcsb pdb:1MEO|rcsb pdb:1NJS|rcsb pdb:1RBM|rcsb pdb:1RBQ|rcsb pdb:1RBY|rcsb pdb:1RBZ|rcsb pdb:1RC0|rcsb pdb:1RC1|rcsb pdb:1ZLX|rcsb pdb:1ZLY|rcsb pdb:2QK4|rcsb pdb:2V9Y|rcsb pdb:4EW1|rcsb pdb:4EW2|rcsb pdb:4EW3|rcsb pdb:4ZYT|interpro:IPR020559|rcsb pdb:4ZYU|rcsb pdb:4ZYV|rcsb pdb:4ZYW|rcsb pdb:4ZYX|rcsb pdb:4ZYY|rcsb pdb:4ZYZ|rcsb pdb:4ZZ0|rcsb pdb:4ZZ1|rcsb pdb:4ZZ2|rcsb pdb:5J9F|rcsb pdb:7JG0|rcsb pdb:4ZZ3|refseq:NP_000810.1|refseq:NP_001129477.1|refseq:NP_001129478.1|refseq:NP_780294.1|rcsb pdb:7JG4|reactome:R-HSA-73817|rcsb pdb:7JG3|refseq:XP_011527828.1|refseq:XP_006724052.1|refseq:XP_006724053.1|refseq:XP_005260998.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7Iy33CtBsB8LHZFDP5mZ3eRX8pU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27816	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715255|uniprotkb:Q59FT2|uniprotkb:Q68D74|uniprotkb:Q6ZUW9|uniprotkb:Q96NS9|uniprotkb:Q13082|uniprotkb:Q96A76|ensembl:ENSP00000353375|uniprotkb:Q86V26	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:map4_human(display_long)|uniprotkb:MAP4(gene name)|psi-mi:MAP4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001127836.1|refseq:NP_002366.2|ensembl:ENSG00000047849(gene)|ensembl:ENST00000360240(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR027323|mint:P27816|refseq:NP_112147.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rBf82W3kFCo+2UklK5WHO3MWjV09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92616	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356221|ensembl:ENSP00000300648|uniprotkb:O95001|uniprotkb:O95651|uniprotkb:Q6P2S3|uniprotkb:Q86X65|uniprotkb:Q8N5I5|uniprotkb:Q8WU80|uniprotkb:Q99736|uniprotkb:Q9UE60|uniprotkb:A8KAY1|intact:EBI-1058692	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gcn1_human(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)|uniprotkb:GCN1-like protein 1(gene name synonym)|uniprotkb:GCN1L1(gene name synonym)|uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)|uniprotkb:KIAA0219(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000089154(gene)|ensembl:ENST00000300648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085|mint:Q92616|reactome:R-HSA-9633012|go:"GO:0005844"(polysome)|refseq:NP_006827.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NtSEW6xjvCkUyb40cnk0JdL5PcA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q04637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92945	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049099|uniprotkb:O00301|uniprotkb:Q59EZ9|uniprotkb:Q5U4P6|uniprotkb:Q9UNT5|uniprotkb:Q9UQH5|intact:EBI-5455671|ensembl:ENSP00000381216	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp2_human(display_long)|uniprotkb:KH type-splicing regulatory protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:KHSRP(gene name)|psi-mi:KHSRP(display_short)|uniprotkb:FUBP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003676.2|ensembl:ENSG00000088247(gene)|ensembl:ENST00000398148(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q92945|rcsb pdb:2HH2|rcsb pdb:2HH3|rcsb pdb:2JVZ|rcsb pdb:2OPU|rcsb pdb:2OPV|rcsb pdb:4B8T|reactome:R-HSA-380994|reactome:R-HSA-450604|dip:DIP-48484N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hlybJllTqSgPgtwwz3kc12zDYh49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07910	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357966|uniprotkb:P22628|uniprotkb:Q53EX2|uniprotkb:Q59FD3|uniprotkb:Q5FWE8|uniprotkb:Q86SF8|uniprotkb:Q86U45|uniprotkb:Q96HK7|uniprotkb:Q96HM4|uniprotkb:Q96IY5|uniprotkb:Q9BTS3|uniprotkb:D3DS19|uniprotkb:D3DS22|intact:EBI-28976506|ensembl:ENSP00000404848|ensembl:ENSP00000451291|ensembl:ENSP00000452276	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpc_human(display_long)|uniprotkb:HNRNPC(gene name)|psi-mi:HNRNPC(display_short)|uniprotkb:HNRPC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070910.1|refseq:NP_001070911.1|refseq:NP_004491.2|refseq:NP_112604.2|ensembl:ENSP00000404848|ensembl:ENST00000430246|ensembl:ENSP00000442816|ensembl:ENST00000553300|ensembl:ENSP00000450544|ensembl:ENSP00000451291|ensembl:ENST00000554969|ensembl:ENSP00000452276|ensembl:ENSP00000450725|ensembl:ENST00000555883|ensembl:ENSP00000450629|ensembl:ENST00000556628|ensembl:ENSP00000451652|ensembl:ENST00000556897|ensembl:ENSP00000451176|refseq:XP_011535010.1|refseq:XP_011535011.1|refseq:XP_011535012.1|refseq:XP_011535013.1|refseq:XP_011535014.1|refseq:XP_016876741.1|refseq:XP_016876742.1|dip:DIP-29854N|refseq:XP_006720188.1|ensembl:ENSG00000092199(gene)|ensembl:ENST00000420743(transcript)|ensembl:ENST00000554455(transcript)|ensembl:ENST00000557201(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR035979|mint:P07910|rcsb pdb:1TXP|rcsb pdb:1WF2|rcsb pdb:2MXY|rcsb pdb:2MZ1|rcsb pdb:3LN4|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Fj5tiH0wrNUjTnsURIg8dB8laMg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99615	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61081	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1041660|uniprotkb:O76069|uniprotkb:Q8VC50|ensembl:ENSP00000253023	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubc12_human(display_long)|uniprotkb:UBE2M(gene name)|psi-mi:UBE2M(display_short)|uniprotkb:UBC12(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 M(gene name synonym)|uniprotkb:NEDD8 carrier protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003960.1|ensembl:ENSG00000130725(gene)|ensembl:ENST00000253023(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61081|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:2NVU|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4GAO|rcsb pdb:4P5O|reactome:R-HSA-2173789|reactome:R-HSA-5607761|reactome:R-HSA-5676590|dip:DIP-35679N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43395	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q05D08	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190283	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q05d08_human(display_long)|uniprotkb:PA2G4(gene name)|psi-mi:PA2G4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR036388|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR018349|interpro:IPR036005|interpro:IPR036390	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JuKG8gmkmCiPRNyb6FtLmZUBbCI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69892	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3910089|uniprotkb:A8MZE0|uniprotkb:P02096|uniprotkb:Q14491|uniprotkb:Q68NH9|uniprotkb:Q96FH6|uniprotkb:P62027|uniprotkb:Q96FH7|ensembl:ENSP00000338082	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg2_human(display_long)|uniprotkb:HBG2(gene name)|psi-mi:HBG2(display_short)|uniprotkb:Gamma-2-globin(gene name synonym)|uniprotkb:Hb F Ggamma(gene name synonym)|uniprotkb:Hemoglobin gamma-2 chain(gene name synonym)|uniprotkb:Hemoglobin gamma-G chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000175.1|ensembl:ENSG00000196565(gene)|ensembl:ENST00000336906(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1FDH|rcsb pdb:4MQJ|rcsb pdb:4MQK|reactome:R-HSA-983231|interpro:IPR002337(Haemoglobin, beta)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nhCM/lc1Dqw+ZTSHjiiyHcJIobk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63244	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14315	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BSJ8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355956|ensembl:ENSP00000377612|uniprotkb:A0FGR7|uniprotkb:A8K2S2|uniprotkb:O94848|uniprotkb:Q6PJN4|uniprotkb:Q9H6J1|uniprotkb:Q9H6W2|uniprotkb:Q9Y416|intact:EBI-4399548	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:esyt1_human(display_long)|uniprotkb:KIAA0747(gene name synonym)|uniprotkb:MBC2(gene name synonym)|uniprotkb:ESYT1(gene name)|psi-mi:ESYT1(display_short)|uniprotkb:Membrane-bound C2 domain-containing protein(gene name synonym)|uniprotkb:FAM62A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR037752|interpro:IPR039010|mint:Q9BSJ8|reactome:R-HSA-1660662|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9035034|interpro:IPR037749|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037733|go:"GO:0005544"(calcium-dependent phospholipid binding)|ensembl:ENSG00000139641(gene)|ensembl:ENST00000394048(transcript)|go:"GO:0005509"(calcium ion binding)|refseq:NP_001171725.1|refseq:NP_056107.1|dip:DIP-57197N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MYbYK3357LLH0TP1qU7CsvJenGk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26641	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51570	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2269932|uniprotkb:B2RC07|intact:EBI-6190170|uniprotkb:B4E1G6|ensembl:ENSP00000225614|ensembl:ENSP00000465930	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:galk1_human(display_long)|uniprotkb:GALK1(gene name)|psi-mi:GALK1(display_short)|uniprotkb:GALK(gene name synonym)|uniprotkb:Galactose kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0019388"(galactose catabolic process)|go:"GO:0019402"(galactitol metabolic process)|go:"GO:0061623"(glycolytic process from galactose)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000705(Galactokinase)|interpro:IPR006203(GHMP kinase, ATP-binding, conserved site)|interpro:IPR006204(GHMP kinase)|interpro:IPR006206(Mevalonate and galactokinase)|interpro:IPR013750(GHMP kinase, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR019539|interpro:IPR019741|interpro:IPR020568|interpro:IPR036554|mint:P51570|ensembl:ENSG00000108479(gene)|ensembl:ENST00000225614(transcript)|ensembl:ENST00000588479(transcript)|go:"GO:0004335"(galactokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005534"(galactose binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0016020"(membrane)|rcsb pdb:1WUU|rcsb pdb:1YH7|rcsb pdb:6GR2|rcsb pdb:6Q3W|rcsb pdb:6Q3X|rcsb pdb:6Q8Z|rcsb pdb:6Q90|rcsb pdb:6Q91|rcsb pdb:6QJE|rcsb pdb:6ZFH|rcsb pdb:6ZGV|rcsb pdb:6ZGW|rcsb pdb:6ZGX|rcsb pdb:6ZGY|rcsb pdb:6ZGZ|reactome:R-HSA-5609976|reactome:R-HSA-70370	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TtFcTQq+nspsst+xInA/huo/ZbU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UPN3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-522925|uniprotkb:E9PJT0|uniprotkb:O75053|uniprotkb:Q5VW20|uniprotkb:Q8WXY2|uniprotkb:Q9H540|uniprotkb:Q9UKP0|uniprotkb:Q9ULG9|intact:EBI-28967632|uniprotkb:B1ALC5|uniprotkb:Q8WXY1|uniprotkb:Q96PK2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:macf1_human(display_long)|uniprotkb:Actin cross-linking family protein 7(gene name synonym)|uniprotkb:Macrophin-1(gene name synonym)|uniprotkb:Trabeculin-alpha(gene name synonym)|uniprotkb:620 kDa actin-binding protein(gene name synonym)|uniprotkb:MACF1(gene name)|psi-mi:MACF1(display_short)|uniprotkb:ABP620(gene name synonym)|uniprotkb:ACF7(gene name synonym)|uniprotkb:KIAA0465(gene name synonym)|uniprotkb:KIAA1251(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000361689|ensembl:ENSP00000354573|ensembl:ENSG00000127603|refseq:NP_036222.3|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0150011"(regulation of neuron projection arborization)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR011992(EF-Hand type)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|rcsb pdb:4Z6G|rcsb pdb:5VE9|rcsb pdb:5X57|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|dip:DIP-50616N|mint:Q9UPN3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G5PesqPZZxQhwDgW0pBJSkJNcZ49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43405	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22626	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299649|ensembl:ENSP00000346694|ensembl:ENSP00000349101|ensembl:ENSP00000354021|ensembl:ENSP00000503360|ensembl:ENSP00000503476|ensembl:ENSP00000503514|ensembl:ENSP00000503885|ensembl:ENSP00000504329|uniprotkb:P22627|uniprotkb:A8K064|uniprotkb:Q9UC98|uniprotkb:Q9UDJ2|uniprotkb:A0A024RA27|uniprotkb:A0A024RA61	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa2_human(display_long)|uniprotkb:HNRNPA2B1(gene name)|psi-mi:HNRNPA2B1(display_short)|uniprotkb:HNRPA2B1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|ensembl:ENST00000679001(transcript)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0050658"(RNA transport)|ensembl:ENST00000679021(transcript)|go:"GO:0070062"(extracellular exosome)|ensembl:ENST00000679123(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:1990428"(miRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034486|interpro:IPR034489|interpro:IPR035979|mint:P22626|rcsb pdb:1X4B|rcsb pdb:5EN1|rcsb pdb:5HO4|rcsb pdb:5WWE|rcsb pdb:5WWF|rcsb pdb:5WWG|rcsb pdb:6WPQ|rcsb pdb:6WQK|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|ensembl:ENSG00000122566(gene)|ensembl:ENST00000354667(transcript)|ensembl:ENST00000356674(transcript)|ensembl:ENST00000360787(transcript)|ensembl:ENST00000676746(transcript)|ensembl:ENST00000678675(transcript)|refseq:NP_002128.1|refseq:NP_112533.1|dip:DIP-32877N|refseq:XP_005249786.1|refseq:XP_016867598.1|refseq:XP_016867599.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N2NeJVio9eYQULNcdE1KXtd2KPw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55060	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P00338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33992	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92522	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876335|ensembl:ENSP00000329662	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h1x_human(display_long)|uniprotkb:H1-10(gene name)|psi-mi:H1-10(display_short)|uniprotkb:H1FX(gene name synonym)|uniprotkb:Histone H1x(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000184897(gene)|ensembl:ENST00000333762(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045296"(cadherin binding)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:Q92522|refseq:NP_006017.1|dip:DIP-36358N|rcsb pdb:2LSO|rcsb pdb:6L9Z|rcsb pdb:7K60|rcsb pdb:7K63	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T+NweCoHXj0rYsS6gJ4V42R9MpA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19320	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9ULH0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716681|uniprotkb:A1L4N4|intact:EBI-2798329|uniprotkb:Q6MZU2|uniprotkb:Q9H889|uniprotkb:Q9H9E4|uniprotkb:Q9NT37|uniprotkb:Q9UF42|uniprotkb:Q4VC08|ensembl:ENSP00000256707	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kdis_human(display_long)|uniprotkb:KIAA1250(gene name synonym)|uniprotkb:KIDINS220(gene name)|psi-mi:KIDINS220(display_short)|uniprotkb:ARMS(gene name synonym)|uniprotkb:Ankyrin repeat-rich membrane-spanning protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065789.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000134313(gene)|ensembl:ENST00000256707(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR002110(Ankyrin)|interpro:IPR011646(KAP P-loop)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9ULH0|reactome:R-HSA-170984|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0wyaXuvXCqQTlfjuW4TAcIGmdlw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14174	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372712|uniprotkb:A5Z1R8|uniprotkb:B2R4S3|uniprotkb:Q6FHV0|uniprotkb:Q2V4Y5|ensembl:ENSP00000215754|ensembl:ENSP00000482779	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mif_human(display_long)|uniprotkb:MIF(gene name)|psi-mi:MIF(display_short)|uniprotkb:MMIF(gene name synonym)|uniprotkb:GLIF(gene name synonym)|uniprotkb:Phenylpyruvate tautomerase(gene name synonym)|uniprotkb:Glycosylation-inhibiting factor(gene name synonym)|uniprotkb:L-dopachrome tautomerase(gene name synonym)|uniprotkb:L-dopachrome isomerase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002406.1|ensembl:ENST00000215754(transcript)|ensembl:ENST00000613839(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004167"(dopachrome isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000276701(gene)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031982"(vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000240972(gene)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045087"(innate immune response)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050178"(phenylpyruvate tautomerase activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001398(Macrophage migration inhibitory factor)|interpro:IPR014347(Tautomerase)|interpro:IPR019829|mint:P14174|rcsb pdb:1CGQ|rcsb pdb:1GCZ|rcsb pdb:1GD0|rcsb pdb:1GIF|rcsb pdb:1LJT|rcsb pdb:1MIF|rcsb pdb:1P1G|rcsb pdb:2OOH|rcsb pdb:2OOW|rcsb pdb:2OOZ|rcsb pdb:3B9S|rcsb pdb:3CE4|rcsb pdb:3DJH|rcsb pdb:3DJI|rcsb pdb:3HOF|rcsb pdb:3IJG|rcsb pdb:3IJJ|rcsb pdb:3JSF|rcsb pdb:3JSG|rcsb pdb:3JTU|rcsb pdb:3L5P|rcsb pdb:3L5R|rcsb pdb:3L5S|rcsb pdb:3L5T|rcsb pdb:3L5U|rcsb pdb:3L5V|rcsb pdb:3SMB|rcsb pdb:3SMC|rcsb pdb:3U18|rcsb pdb:3WNR|rcsb pdb:3WNS|rcsb pdb:3WNT|rcsb pdb:4ETG|rcsb pdb:4EUI|rcsb pdb:4EVG|rcsb pdb:4F2K|rcsb pdb:4GRN|rcsb pdb:4GRO|rcsb pdb:4GRP|rcsb pdb:4GRQ|rcsb pdb:4GRR|rcsb pdb:4GRU|rcsb pdb:4GUM|rcsb pdb:4K9G|rcsb pdb:4OSF|rcsb pdb:4OYQ|rcsb pdb:4P01|rcsb pdb:4P0H|rcsb pdb:4PKK|rcsb pdb:4PKZ|rcsb pdb:4PLU|rcsb pdb:4TRF|rcsb pdb:4TRU|rcsb pdb:4WR8|rcsb pdb:4WRB|rcsb pdb:4XX7|rcsb pdb:4XX8|rcsb pdb:4Z15|rcsb pdb:4Z1T|rcsb pdb:4Z1U|rcsb pdb:5B4O|rcsb pdb:5BS9|rcsb pdb:5BSC|rcsb pdb:5BSI|rcsb pdb:5BSJ|rcsb pdb:5EIZ|rcsb pdb:5HVS|rcsb pdb:5HVT|rcsb pdb:5HVV|rcsb pdb:5J7P|rcsb pdb:5J7Q|rcsb pdb:5UMJ|rcsb pdb:5UMK|rcsb pdb:5UZY|rcsb pdb:5V70|rcsb pdb:5V73|rcsb pdb:5XEJ|rcsb pdb:1CA7|rcsb pdb:6B1C|rcsb pdb:6B1K|rcsb pdb:6B2C|rcsb pdb:6BG6|rcsb pdb:6BG7|rcsb pdb:6CB5|rcsb pdb:6CBF|rcsb pdb:6CBG|rcsb pdb:6FVE|rcsb pdb:6FVH|rcsb pdb:6OY8|rcsb pdb:6OYB|rcsb pdb:6OYE|rcsb pdb:6OYG|rcsb pdb:6PEG|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-8950505|rcsb pdb:6CBH|dip:DIP-31137N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Vk+Sfaz5c59y8dKKJ4Qn+7fjwvQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99873	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09651	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352662|uniprotkb:Q3MIB7|uniprotkb:Q6PJZ7|ensembl:ENSP00000341826|ensembl:ENSP00000503610|uniprotkb:A8K4Z8|intact:EBI-2556572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa1_human(display_long)|uniprotkb:HNRNPA1(gene name)|psi-mi:HNRNPA1(display_short)|uniprotkb:HNRPA1(gene name synonym)|uniprotkb:Helix-destabilizing protein(gene name synonym)|uniprotkb:Single-strand RNA-binding protein(gene name synonym)|uniprotkb:hnRNP core protein A1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002127.1|refseq:NP_112420.1|ensembl:ENSG00000135486(gene)|ensembl:ENST00000340913(transcript)|ensembl:ENST00000677210(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|rcsb pdb:2LYV|rcsb pdb:2UP1|rcsb pdb:4YOE|rcsb pdb:5MPG|rcsb pdb:5MPL|rcsb pdb:5ZGD|rcsb pdb:5ZGL|rcsb pdb:6BXX|rcsb pdb:6DCL|rcsb pdb:6J60|rcsb pdb:7BX7|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035198"(miRNA binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051168"(nuclear export)|go:"GO:0051170"(import into nucleus)|go:"GO:0061752"(telomeric repeat-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR034845|interpro:IPR035979|mint:P09651|rcsb pdb:1HA1|rcsb pdb:1L3K|rcsb pdb:1PGZ|rcsb pdb:1PO6|rcsb pdb:1U1K|rcsb pdb:1U1L|rcsb pdb:1U1M|rcsb pdb:1U1N|rcsb pdb:1U1O|rcsb pdb:1U1P|rcsb pdb:1U1Q|rcsb pdb:1U1R|rcsb pdb:1UP1|rcsb pdb:2H4M|refseq:XP_005268883.1|dip:DIP-29338N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ECXjsLRVtNc/aOw90tEFxowHc6c9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6UY14	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742002|uniprotkb:Q5T5F7|uniprotkb:Q6IPM6|uniprotkb:Q8N643|uniprotkb:Q9HBS6|ensembl:ENSP00000271643|ensembl:ENSP00000358034|uniprotkb:B2RTT0|uniprotkb:F8WAD0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atl4_human(display_long)|uniprotkb:Thrombospondin repeat-containing protein 1(gene name synonym)|uniprotkb:ADAMTSL4(gene name)|psi-mi:ADAMTSL4(display_short)|uniprotkb:TSRC1(gene name synonym)|uniprotkb:PP1396(orf name)|uniprotkb:UNQ2803/PRO34012(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061905.2|refseq:NP_079284.2|ensembl:ENSG00000143382(gene)|ensembl:ENST00000271643(transcript)|ensembl:ENST00000369038(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006915"(apoptotic process)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR036383|mint:Q6UY14|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005576"(extracellular region)|refseq:NP_001275536.1|refseq:NP_001275537.1|refseq:XP_011507950.1|refseq:XP_016856995.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HIXY8OQopS51RVemJo0GTj8V0WQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BYB4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190293|ensembl:ENSP00000331313|ensembl:ENSP00000385154|uniprotkb:Q9H2S2|uniprotkb:Q9H4M4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gnb1l_human(display_long)|uniprotkb:GNB1L(gene name)|psi-mi:GNB1L(display_short)|uniprotkb:GY2(gene name synonym)|uniprotkb:KIAA1645(gene name synonym)|uniprotkb:WDR14(gene name synonym)|uniprotkb:DGCRK3(gene name synonym)|uniprotkb:WD repeat-containing protein 14(gene name synonym)|uniprotkb:WD40 repeat-containing protein deleted in VCFS(gene name synonym)|uniprotkb:FKSG1(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensembl:ENSG00000185838(gene)|ensembl:ENST00000329517(transcript)|ensembl:ENST00000403325(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_443730.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:txIUhYulfQGg1ly2Kgj27FNf+9U9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y2Q3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053767|uniprotkb:Q7Z520|uniprotkb:Q6P4H0|uniprotkb:Q9P1S4|uniprotkb:B4DIH1|uniprotkb:B4DSY2|ensembl:ENSP00000351181	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstk1_human(display_long)|uniprotkb:Glutathione S-transferase subunit 13(gene name synonym)|uniprotkb:GST 13-13(gene name synonym)|uniprotkb:GST class-kappa(gene name synonym)|uniprotkb:GSTK1-1(gene name synonym)|uniprotkb:GSTK1(gene name)|psi-mi:GSTK1(display_short)|uniprotkb:HDCMD47P(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001137151.1|refseq:NP_001137152.1|refseq:NP_001137153.1|refseq:NP_057001.1|ensembl:ENSG00000197448(gene)|ensembl:ENST00000358406(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001853(DSBA oxidoreductase)|interpro:IPR014440(HCCA isomerase/glutathione S-transferase kappa)|interpro:IPR036249|interpro:IPR044088|rcsb pdb:1YZX|rcsb pdb:3RPN|rcsb pdb:3RPP|reactome:R-HSA-156590|reactome:R-HSA-9033241|dip:DIP-46924N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aTjqqss32Y4bcsXg6gYlazahVCw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9HAV4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09496	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60610	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02538	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99661	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642317|uniprotkb:Q96C18|uniprotkb:Q96HB8|uniprotkb:Q9BWV8|uniprotkb:Q5JR88|uniprotkb:B3ITR9|uniprotkb:Q6ICU1|ensembl:ENSP00000361298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kif2c_human(display_long)|uniprotkb:KNSL6(gene name synonym)|uniprotkb:KIF2C(gene name)|psi-mi:KIF2C(display_short)|uniprotkb:Mitotic centromere-associated kinesin(gene name synonym)|uniprotkb:Kinesin-like protein 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006836.2|refseq:NP_001284584.1|refseq:NP_001284585.1|refseq:NP_001284586.1|ensembl:ENSG00000142945(gene)|ensembl:ENST00000372224(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q99661|rcsb pdb:2HEH|rcsb pdb:4UBF|rcsb pdb:4Y05|rcsb pdb:5MIO|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XKQr6i+9Xtdfir6V1C8PByAIg1c9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NR56	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2805004|uniprotkb:O43797|uniprotkb:O43311|uniprotkb:Q86UV8|uniprotkb:Q96P92|uniprotkb:Q96RE3|uniprotkb:E9PBW7|uniprotkb:Q86UV9|ensembl:ENSP00000282486|ensembl:ENSP00000418108	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mbnl1_human(display_long)|uniprotkb:EXP(gene name synonym)|uniprotkb:KIAA0428(gene name synonym)|uniprotkb:MBNL(gene name synonym)|uniprotkb:Triplet-expansion RNA-binding protein(gene name synonym)|uniprotkb:MBNL1(gene name)|psi-mi:MBNL1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011511149.1|refseq:XP_011511151.1|refseq:NP_001300986.1|refseq:NP_066368.2|refseq:NP_997175.1|refseq:NP_997176.1|refseq:NP_997177.1|refseq:NP_997178.1|refseq:NP_997179.1|refseq:NP_997180.1|refseq:XP_005247523.1|refseq:XP_005247528.1|ensembl:ENSP00000282486|ensembl:ENST00000324196|ensembl:ENSP00000319374|ensembl:ENST00000324210|ensembl:ENSP00000319429|ensembl:ENST00000355460|ensembl:ENSP00000347637|ensembl:ENST00000357472|ensembl:ENSP00000350064|ensembl:ENSP00000418108|ensembl:ENST00000465907|ensembl:ENSP00000417630|ensembl:ENST00000485509|ensembl:ENSP00000418876|ensembl:ENST00000485910|ensembl:ENSP00000418427|ensembl:ENST00000492948|ensembl:ENSP00000420103|ensembl:ENST00000545754|ensembl:ENSP00000437491|interpro:IPR000571(Zinc finger, CCCH-type)|mint:Q9NR56|rcsb pdb:3D2N|rcsb pdb:3D2Q|rcsb pdb:3D2S|rcsb pdb:5U6H|rcsb pdb:5U6L|rcsb pdb:5U9B|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000152601(gene)|ensembl:ENST00000282486(transcript)|ensembl:ENST00000463374(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045445"(myoblast differentiation)|refseq:XP_016861914.1|refseq:XP_016861915.1|refseq:XP_016861916.1|refseq:XP_016861917.1|refseq:XP_016861918.1|refseq:XP_016861919.1|refseq:XP_016861920.1|refseq:XP_016861925.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uvyDik76f41mvxO2j/dUD6mKMOk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38646	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10412	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358163|uniprotkb:Q4VB25|ensembl:ENSP00000307705	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h14_human(display_long)|uniprotkb:H1-4(gene name)|psi-mi:H1-4(display_short)|uniprotkb:H1F4(gene name synonym)|uniprotkb:HIST1H1E(gene name synonym)|uniprotkb:Histone H1b(gene name synonym)|uniprotkb:Histone H1s-4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005312.1|rcsb pdb:6H8P|rcsb pdb:7K5Y|rcsb pdb:7K63|go:"GO:0032564"(dATP binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P10412|rcsb pdb:3TZD|rcsb pdb:5JJZ|reactome:R-HSA-140342|reactome:R-HSA-2559584|ensembl:ENSG00000168298(gene)|ensembl:ENST00000304218(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000792"(heterochromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016208"(AMP binding)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yT8wBbspLLR8G3DrgpFeWEOPgac9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43678	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bL66utte1nSuYj0nxg/BoktnXhs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BZX2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053938|uniprotkb:Q5VV91|uniprotkb:Q7KZV3|uniprotkb:Q92528|uniprotkb:Q96KG5|uniprotkb:Q9BU42|ensembl:ENSP00000356853|intact:EBI-21355463	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:uck2_human(display_long)|uniprotkb:Uridine monophosphokinase 2(gene name synonym)|uniprotkb:Cytidine monophosphokinase 2(gene name synonym)|uniprotkb:UCK2(gene name)|psi-mi:UCK2(display_short)|uniprotkb:Testis-specific protein TSA903(gene name synonym)|uniprotkb:UMPK(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036606.2|ensembl:ENSG00000143179(gene)|ensembl:ENST00000367879(transcript)|go:"GO:0004849"(uridine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044206"(UMP salvage)|go:"GO:0044211"(CTP salvage)|interpro:IPR000764(Uridine kinase)|interpro:IPR006083(Phosphoribulokinase/uridine kinase)|interpro:IPR027417|interpro:IPR029925|rcsb pdb:1UDW|rcsb pdb:1UEI|rcsb pdb:1UEJ|rcsb pdb:1UFQ|rcsb pdb:1UJ2|rcsb pdb:1XRJ|rcsb pdb:6N53|rcsb pdb:6N54|rcsb pdb:6N55|rcsb pdb:6PWZ|reactome:R-HSA-73614	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rk530GVV4ltYepCzVu5qVMYv5uI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06493	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14818	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-603272|uniprotkb:Q9BR53|uniprotkb:Q9H4K5|uniprotkb:Q9UEU8|uniprotkb:B2R515|uniprotkb:Q5JXJ2|ensembl:ENSP00000359910	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa7_human(display_long)|uniprotkb:PSMA7(gene name)|psi-mi:PSMA7(display_short)|uniprotkb:Proteasome subunit RC6-1(gene name synonym)|uniprotkb:Proteasome subunit XAPC7(gene name synonym)|uniprotkb:HSPC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002783.1|dip:DIP-29363N|ensembl:ENSG00000101182(gene)|ensembl:ENST00000370873(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098794"(postsynapse)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035190|mint:O14818|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:J1M+b+VK02BAn2OnZISjjlmO8dc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WWM7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-948363|ensembl:ENSP00000338718|uniprotkb:O95135|uniprotkb:Q6NVJ8|uniprotkb:Q6PJW6|uniprotkb:Q8IU61|uniprotkb:Q8IU95|uniprotkb:Q8WWM3|uniprotkb:Q8WWM4|uniprotkb:Q8WWM5|uniprotkb:Q8WWM6|uniprotkb:Q99703|uniprotkb:B9EGM2|uniprotkb:E9PAR9|uniprotkb:A8K1R6|uniprotkb:Q63ZY4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atx2l_human(display_long)|uniprotkb:Ataxin-2 domain protein(gene name synonym)|uniprotkb:Ataxin-2-related protein(gene name synonym)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)|uniprotkb:A2D(gene name synonym)|uniprotkb:A2LG(gene name synonym)|uniprotkb:A2LP(gene name synonym)|uniprotkb:A2RP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000168488(gene)|ensembl:ENST00000336783(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045296"(cadherin binding)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q8WWM7|refseq:NP_009176.2|refseq:NP_663760.1|refseq:NP_680780.1|refseq:NP_680781.1|refseq:XP_005255123.1|refseq:NP_059867.3|refseq:NP_680782.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:t7lrS10IM/5pt+rrbqBRowZ6b+09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62495	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750990|intact:EBI-1047744|uniprotkb:B2R6B4|uniprotkb:D3DQC1|uniprotkb:P46055|uniprotkb:Q5M7Z7|uniprotkb:Q96CG1|ensembl:ENSP00000353741	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:erf1_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)|uniprotkb:ERF1(gene name synonym)|uniprotkb:Protein Cl1(gene name synonym)|uniprotkb:RF1(gene name synonym)|uniprotkb:SUP45L1(gene name synonym)|uniprotkb:TB3-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004721.1|refseq:NP_001243231.1|refseq:NP_001278903.1|refseq:NP_001278904.1|refseq:XP_005271978.1|ensembl:ENSG00000120705(gene)|ensembl:ENST00000360541(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0043022"(ribosome binding)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|mint:P62495|rcsb pdb:1DT9|rcsb pdb:2HST|rcsb pdb:2KTU|rcsb pdb:2KTV|rcsb pdb:2LGT|rcsb pdb:2LLX|rcsb pdb:2MQ6|rcsb pdb:2MQ9|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3JAG|rcsb pdb:3JAH|rcsb pdb:3JAI|rcsb pdb:4D5N|rcsb pdb:4D61|rcsb pdb:5A8L|rcsb pdb:5LZT|rcsb pdb:5LZU|rcsb pdb:5LZV|rcsb pdb:6D90|rcsb pdb:6IP8|rcsb pdb:6XA1|rcsb pdb:6ZME|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8IWZ3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359558|ensembl:ENSP00000354085|intact:EBI-948598|uniprotkb:A6NH85|uniprotkb:Q149P2|uniprotkb:Q8IWZ2|uniprotkb:Q8WY90|uniprotkb:Q96G77|uniprotkb:Q96GK0|uniprotkb:Q9H2U0|uniprotkb:Q9HA95|uniprotkb:Q9NWG4|uniprotkb:Q9UPR7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ankh1_human(display_long)|uniprotkb:Multiple ankyrin repeats single KH domain(gene name synonym)|uniprotkb:ANKHD1(gene name)|psi-mi:ANKHD1(display_short)|uniprotkb:HIV-1 Vpr-binding ankyrin repeat protein(gene name synonym)|uniprotkb:KIAA1085(gene name synonym)|uniprotkb:MASK(gene name synonym)|uniprotkb:VBARP(gene name synonym)|uniprotkb:PP2500(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000131503(gene)|ensembl:ENST00000360839(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|refseq:NP_001183959.1|refseq:NP_060217.1|refseq:NP_060448.1|refseq:NP_078944.2|refseq:NP_065741.3|ensembl:ENSP00000354085|ensembl:ENST00000394722|ensembl:ENSP00000378211|ensembl:ENST00000394723|ensembl:ENSP00000378212|ensembl:ENST00000616482|ensembl:ENSP00000478529|dip:DIP-36371N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yPjTR77ttPwAEMg8WHOzYJNcAhA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62993	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13151	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724092|ensembl:ENSP00000316042|intact:EBI-1043661|uniprotkb:Q6IB18	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa0_human(display_long)|uniprotkb:HNRPA0(gene name synonym)|uniprotkb:HNRNPA0(gene name)|psi-mi:HNRNPA0(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006796.1|ensembl:ENSG00000177733(gene)|ensembl:ENST00000314940(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034801|interpro:IPR035979|mint:Q13151|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:buyQxR8FLxd4N6jRhwVsroeGrBw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00233	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750973|uniprotkb:Q9BQ42|uniprotkb:G3V1Q6|uniprotkb:B2RD35|intact:EBI-28988356|ensembl:ENSP00000440485	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd9_human(display_long)|uniprotkb:26S proteasome regulatory subunit p27(gene name synonym)|uniprotkb:PSMD9(gene name)|psi-mi:PSMD9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002804.2|refseq:NP_001248329.1|ensembl:ENST00000537407|ensembl:ENSP00000445058|ensembl:ENSP00000440485|ensembl:ENST00000542602|ensembl:ENSP00000443772|ensembl:ENSG00000110801(gene)|ensembl:ENST00000541212(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0070682"(proteasome regulatory particle assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR035269|interpro:IPR036034|interpro:IPR040815|interpro:IPR041489|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|go:"GO:0003713"(transcription coactivator activity)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OkUTrgO5lFTumVtMd+3vZTf3TPc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07814	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UBC2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2556746|intact:EBI-28972990|ensembl:ENSP00000248070|uniprotkb:B4DKA3|uniprotkb:A2RRF3|uniprotkb:A5PL29	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ep15r_human(display_long)|uniprotkb:EPS15R(gene name synonym)|uniprotkb:Eps15-related protein(gene name synonym)|uniprotkb:EPS15L1(gene name)|psi-mi:EPS15L1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_067058.1|ensembl:ENSP00000248070|ensembl:ENST00000455140|ensembl:ENSP00000393313|ensembl:ENST00000535753|ensembl:ENSP00000440103|ensembl:ENST00000597937|ensembl:ENSP00000472267|ensembl:ENST00000602022|ensembl:ENSP00000471981|ensembl:ENSG00000127527(gene)|ensembl:ENST00000248070(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0045296"(cadherin binding)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q9UBC2|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0030132"(clathrin coat of coated pit)|refseq:NP_001245303.1|refseq:NP_001245304.1|refseq:NP_001245305.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6Bsao5czetxRxIiy3O/rZox4U+Y9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y295	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719554|uniprotkb:Q6FGP8|uniprotkb:Q8WW69|uniprotkb:Q9UGF2|uniprotkb:B2RDS8|ensembl:ENSP00000329715	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:drg1_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 3(gene name synonym)|uniprotkb:DRG1(gene name)|psi-mi:DRG1(display_short)|uniprotkb:NEDD3(gene name synonym)|uniprotkb:Translation factor GTPase DRG1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004138.1|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|rcsb pdb:2EKI|go:"GO:0005844"(polysome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007275"(multicellular organism development)|ensembl:ENSG00000185721(gene)|ensembl:ENST00000331457(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gVbgvaeulEwp7MdnP+qRgZ/aawA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54136	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355482|uniprotkb:Q9BWA1|uniprotkb:B2RBS9|uniprotkb:Q53GY4|intact:EBI-28985219|ensembl:ENSP00000231572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syrc_human(display_long)|uniprotkb:RARS1(gene name)|psi-mi:RARS1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:RARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002878.2|ensembl:ENSG00000113643(gene)|ensembl:ENST00000231572(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:P54136|rcsb pdb:4Q2T|rcsb pdb:4Q2X|rcsb pdb:4Q2Y|rcsb pdb:4R3Z|rcsb pdb:4ZAJ|reactome:R-HSA-2408522|reactome:R-HSA-379716|ensembl:ENSP00000231572	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oM9gWF1NucjgVjBFm4DcjmnQNCE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96AE4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711404|uniprotkb:Q12828|ensembl:ENSP00000359804	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp1_human(display_long)|uniprotkb:FUBP1(gene name)|psi-mi:FUBP1(display_short)|uniprotkb:DNA helicase V(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q96AE4|rcsb pdb:1J4W|rcsb pdb:2KXH|rcsb pdb:4LIJ|rcsb pdb:6Y24|rcsb pdb:6Y2C|rcsb pdb:6Y2D|ensembl:ENSG00000162613(gene)|ensembl:ENST00000370768(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|refseq:NP_003893.2|refseq:NP_001290362.1|refseq:XP_016858232.1|dip:DIP-47273N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:38IaQgYv8qLMAryXO0lbfzgjjsM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H583	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048716|uniprotkb:Q5T3Q8|uniprotkb:Q6P197|uniprotkb:Q9NW23|ensembl:ENSP00000355541	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:heat1_human(display_long)|uniprotkb:Protein BAP28(gene name synonym)|uniprotkb:HEATR1(gene name)|psi-mi:HEATR1(display_short)|uniprotkb:BAP28(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein 10 homolog(gene name synonym)|uniprotkb:UTP10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060542.4|ensembl:ENSG00000119285(gene)|ensembl:ENST00000366582(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034455"(t-UTP complex)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012954(BP28, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022125|interpro:IPR040191|mint:Q9H583|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0WoP84UUVfXWppmvCYa/n5GTzc89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05787	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297852|uniprotkb:Q14099|uniprotkb:Q14716|uniprotkb:Q14717|uniprotkb:Q53GJ0|uniprotkb:Q6DHW5|uniprotkb:Q6GMY0|uniprotkb:Q6P4C7|uniprotkb:Q96J60|ensembl:ENSP00000293308|ensembl:ENSP00000447402|ensembl:ENSP00000447566|uniprotkb:A8K4H3|uniprotkb:B0AZN5|uniprotkb:F8VXB4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c8_human(display_long)|uniprotkb:Keratin-8(gene name synonym)|uniprotkb:KRT8(gene name)|psi-mi:KRT8(display_short)|uniprotkb:CYK8(gene name synonym)|uniprotkb:Cytokeratin-8(gene name synonym)|uniprotkb:Type-II keratin Kb8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243222.1|ensembl:ENSG00000170421(gene)|ensembl:ENST00000293308(transcript)|ensembl:ENST00000546897(transcript)|ensembl:ENST00000552551(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030018"(Z disc)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051707"(response to other organism)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P05787|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_002264.1|dip:DIP-424N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zyV8eOjx426ehjJYK4jsizORUws9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NZM3-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190150|ensembl:ENSP00000354561	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q9nzm3-2(display_long)|uniprotkb:ITSN2(gene name)|psi-mi:ITSN2(display_short)|uniprotkb:KIAA1256(gene name synonym)|uniprotkb:SH3D1B(gene name synonym)|uniprotkb:SWAP(gene name synonym)|uniprotkb:SH3 domain-containing protein 1B(gene name synonym)|uniprotkb:SH3P18(gene name synonym)|uniprotkb:SH3P18-like WASP-associated protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198399(gene)|ensembl:ENST00000361999(transcript)|intact:EBI-308689(isoform-parent)|uniprotkb:Q9NZM3-2(isoform-parent)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WTz75JabFgL3LVJ2FJZk81RTmfY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99729	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044873|uniprotkb:Q04150|uniprotkb:Q8N7U3|uniprotkb:Q9BQ99|intact:EBI-2339961|uniprotkb:B3KNN5|uniprotkb:D3DWP7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roaa_human(display_long)|uniprotkb:HNRPAB(gene name synonym)|uniprotkb:APOBEC1-binding protein 1(gene name synonym)|uniprotkb:HNRNPAB(gene name)|psi-mi:HNRNPAB(display_short)|uniprotkb:ABBP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004490.2|refseq:NP_112556.2|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR034846|interpro:IPR035979|rcsb pdb:3S7R|mint:Q99729|dip:DIP-50394N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NzusDKSvcoVb90LNvXpaMAvg0Oo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31946	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24534	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354334|uniprotkb:Q6IBH9|uniprotkb:A8K795|ensembl:ENSP00000236957|ensembl:ENSP00000376055|ensembl:ENSP00000376056|ensembl:ENSP00000489993|ensembl:ENSP00000490214|ensembl:ENSP00000490326	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1b_human(display_long)|uniprotkb:EEF1B(gene name synonym)|uniprotkb:EF1B(gene name synonym)|uniprotkb:EEF1B2(gene name)|psi-mi:EEF1B2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032752.1|refseq:NP_001950.1|refseq:NP_066944.1|ensembl:ENSG00000114942(gene)|ensembl:ENSG00000283391(gene)|ensembl:ENST00000236957(transcript)|ensembl:ENST00000392221(transcript)|ensembl:ENST00000392222(transcript)|ensembl:ENST00000635728(transcript)|ensembl:ENST00000636275(transcript)|ensembl:ENST00000637253(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0045471"(response to ethanol)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219|interpro:IPR036282|mint:P24534|rcsb pdb:1B64|rcsb pdb:5DQS|reactome:R-HSA-156842	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:d4zkwQOMlpr6XBapMfT1sxy2ZPs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78344	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-296519|uniprotkb:O60877|uniprotkb:P78404|uniprotkb:Q0VH00|uniprotkb:Q53EU1|uniprotkb:Q58EZ2|uniprotkb:Q8NI71|uniprotkb:Q96C16|ensembl:ENSP00000340281|ensembl:ENSP00000433371|ensembl:ENSP00000433664|uniprotkb:Q0VH01|uniprotkb:Q2NKW9|uniprotkb:Q49A79	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4g2_human(display_long)|uniprotkb:EIF4G2(gene name)|psi-mi:EIF4G2(display_short)|uniprotkb:DAP5(gene name synonym)|uniprotkb:OK/SW-cl.75(orf name)|uniprotkb:p97(gene name synonym)|uniprotkb:Death-associated protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000110321(gene)|ensembl:ENST00000339995(transcript)|ensembl:ENST00000525681(transcript)|ensembl:ENST00000526148(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007507"(heart development)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008219"(cell death)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:P78344|rcsb pdb:3D3M|rcsb pdb:3L6A|rcsb pdb:4IUL|reactome:R-HSA-1169408|refseq:NP_001036024.3|refseq:NP_001166176.1|refseq:NP_001409.3|dip:DIP-31366N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UIE1Um0s2KJ9hpaa9X6kfZ8enPc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60228	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:s09LicCa0mb9WwO7esZvVdvUonY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96PU8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945792|uniprotkb:Q2I375|uniprotkb:Q5MJQ1|uniprotkb:Q969L9|uniprotkb:Q96EJ3|uniprotkb:Q96KA3|uniprotkb:Q96PU6|uniprotkb:Q96PU7|uniprotkb:Q9P0X6|uniprotkb:Q9P0X7|uniprotkb:Q9P0X8|uniprotkb:Q9P0X9|uniprotkb:Q9P0Y0|uniprotkb:Q9P0Y1|ensembl:ENSP00000355094	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:qki_human(display_long)|uniprotkb:QKI(gene name)|psi-mi:QKI(display_short)|uniprotkb:HKQ(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006766.1|refseq:NP_996735.1|refseq:NP_996736.1|refseq:NP_996737.1|refseq:NP_001288014.1|refseq:XP_011534561.1|ensembl:ENSG00000112531(gene)|ensembl:ENST00000361752(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0007286"(spermatid development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042552"(myelination)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0045202"(synapse)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032367|interpro:IPR032377|interpro:IPR036612|mint:Q96PU8|rcsb pdb:4JVH|reactome:R-HSA-6802952	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7dcw5OyNAhQTE+yTch3qbSlZJdE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42704	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33993	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00541	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053271|uniprotkb:Q6IC29|ensembl:ENSP00000346725	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pesc_human(display_long)|uniprotkb:PES1(gene name)|psi-mi:PES1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001230154.1|refseq:NP_055118.1|ensembl:ENSG00000100029(gene)|ensembl:ENST00000354694(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000466"("maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|interpro:IPR001357(BRCT)|interpro:IPR010613(Pescadillo, N-terminal)|interpro:IPR036420|rcsb pdb:2EP8|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Nq1SJ37kJfe+vF9zmNASz1gnbfY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N163	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13155	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745226|uniprotkb:Q75MR1|uniprotkb:Q96CZ5|uniprotkb:Q9P1L2|ensembl:ENSP00000223029|uniprotkb:F8W950	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:aimp2_human(display_long)|uniprotkb:Protein JTV-1(gene name synonym)|uniprotkb:AIMP2(gene name)|psi-mi:AIMP2(display_short)|uniprotkb:PRO0992(orf name)|uniprotkb:JTV1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006294.2|ensembl:ENSG00000106305(gene)|ensembl:ENST00000223029(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903632"(positive regulation of aminoacyl-tRNA ligase activity)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR031889|interpro:IPR036282|interpro:IPR041503|interpro:IPR042360|mint:Q13155|rcsb pdb:4DPG|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5Y6L|rcsb pdb:6ILD|rcsb pdb:6IY6|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-34421N|refseq:NP_001313536.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VEBmJjo6t3dBY6mKpmUyVLamJFQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26583	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057009|uniprotkb:Q5U072|uniprotkb:D3DP37|uniprotkb:B2R4K8|ensembl:ENSP00000296503|ensembl:ENSP00000393448|ensembl:ENSP00000404912	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmgb2_human(display_long)|uniprotkb:HMGB2(gene name)|psi-mi:HMGB2(display_short)|uniprotkb:HMG2(gene name synonym)|uniprotkb:High mobility group protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001124160.1|refseq:NP_001124161.1|refseq:NP_002120.1|ensembl:ENSG00000164104(gene)|ensembl:ENST00000296503(transcript)|ensembl:ENST00000438704(transcript)|ensembl:ENST00000446922(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032075"(positive regulation of nuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042056"(chemoattractant activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044378"(non-sequence-specific DNA binding, bending)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR036910|mint:P26583|reactome:R-HSA-140342	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ACzaSeIwT3vM4ZgpCSSlzA6nd4U9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69905	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714680|uniprotkb:P01922|ensembl:ENSP00000251595|ensembl:ENSP00000322421|uniprotkb:Q3MIF5|uniprotkb:Q96KF1|uniprotkb:Q9NYR7|uniprotkb:Q1HDT5|uniprotkb:Q53F97|uniprotkb:Q9UCM0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hba_human(display_long)|uniprotkb:Hemoglobin alpha chain(gene name synonym)|uniprotkb:Alpha-globin(gene name synonym)|uniprotkb:HBA1(gene name)|psi-mi:HBA1(display_short)|uniprotkb:HBA2(gene name)|psi-mi:HBA2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000188536(gene)|ensembl:ENSG00000206172(gene)|ensembl:ENST00000251595(transcript)|ensembl:ENST00000320868(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015671"(oxygen transport)|go:"GO:0016020"(membrane)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002339(Haemoglobin, pi)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|mint:P69905|rcsb pdb:1A00|rcsb pdb:1A01|rcsb pdb:1A0U|rcsb pdb:1A0Z|rcsb pdb:1A3N|rcsb pdb:1A3O|rcsb pdb:1A9W|rcsb pdb:1ABW|rcsb pdb:1ABY|rcsb pdb:1AJ9|rcsb pdb:1B86|rcsb pdb:1BAB|rcsb pdb:1BBB|rcsb pdb:1BIJ|rcsb pdb:1BUW|rcsb pdb:1BZ0|rcsb pdb:1BZ1|rcsb pdb:1BZZ|rcsb pdb:1C7B|rcsb pdb:1C7C|rcsb pdb:1C7D|rcsb pdb:1CLS|rcsb pdb:1CMY|rcsb pdb:1COH|rcsb pdb:1DKE|rcsb pdb:1DXT|rcsb pdb:1DXU|rcsb pdb:1DXV|rcsb pdb:1FDH|rcsb pdb:1FN3|rcsb pdb:1G9V|rcsb pdb:1YVQ|rcsb pdb:1YVT|rcsb pdb:1YZI|rcsb pdb:1Z8U|rcsb pdb:2D5Z|rcsb pdb:2D60|rcsb pdb:2DN1|rcsb pdb:2DN2|rcsb pdb:2DN3|rcsb pdb:2DXM|rcsb pdb:2H35|rcsb pdb:2HBC|rcsb pdb:2HBD|rcsb pdb:2HBE|rcsb pdb:2HBF|rcsb pdb:2HBS|rcsb pdb:2HCO|rcsb pdb:2HHB|rcsb pdb:2HHD|rcsb pdb:2HHE|rcsb pdb:2M6Z|rcsb pdb:2W6V|rcsb pdb:2W72|rcsb pdb:2YRS|rcsb pdb:3B75|rcsb pdb:3D17|rcsb pdb:3D7O|rcsb pdb:3DUT|rcsb pdb:3HHB|rcsb pdb:3HXN|rcsb pdb:3IA3|rcsb pdb:3IC0|rcsb pdb:3IC2|rcsb pdb:3KMF|rcsb pdb:3NL7|rcsb pdb:3NMM|rcsb pdb:3ODQ|rcsb pdb:3ONZ|rcsb pdb:3OO4|rcsb pdb:3OO5|rcsb pdb:3OVU|rcsb pdb:3P5Q|rcsb pdb:3QJB|rcsb pdb:3QJC|rcsb pdb:3QJD|rcsb pdb:3QJE|rcsb pdb:3R5I|rcsb pdb:3S48|rcsb pdb:3S65|rcsb pdb:3S66|rcsb pdb:3SZK|rcsb pdb:3WCP|rcsb pdb:3WHM|rcsb pdb:4FC3|rcsb pdb:4HHB|rcsb pdb:4IJ2|rcsb pdb:4L7Y|rcsb pdb:4M4A|rcsb pdb:4M4B|rcsb pdb:4MQC|rcsb pdb:4MQG|rcsb pdb:4MQH|rcsb pdb:4MQI|rcsb pdb:4MQJ|rcsb pdb:4MQK|rcsb pdb:4X0L|rcsb pdb:4XS0|rcsb pdb:5E29|rcsb pdb:5E6E|rcsb pdb:5E83|rcsb pdb:5EE4|rcsb pdb:5HU6|rcsb pdb:5HY8|rcsb pdb:5JDO|rcsb pdb:5KDQ|rcsb pdb:5KSI|rcsb pdb:5KSJ|rcsb pdb:5NI1|rcsb pdb:5SW7|rcsb pdb:5U3I|rcsb pdb:5UCU|rcsb pdb:5UFJ|rcsb pdb:5URC|rcsb pdb:5VMM|rcsb pdb:5WOG|rcsb pdb:5WOH|rcsb pdb:5X2R|rcsb pdb:5X2S|rcsb pdb:5X2T|rcsb pdb:5X2U|rcsb pdb:6BB5|rcsb pdb:6BNR|rcsb pdb:6BWP|rcsb pdb:6BWU|rcsb pdb:6DI4|rcsb pdb:6HAL|rcsb pdb:6HBW|rcsb pdb:6HK2|rcsb pdb:6KA9|rcsb pdb:6KAE|rcsb pdb:6KAH|rcsb pdb:6KAI|rcsb pdb:6KAO|rcsb pdb:6KAP|rcsb pdb:6KAQ|rcsb pdb:6KAR|rcsb pdb:6KAS|rcsb pdb:6KAT|rcsb pdb:4N7N|rcsb pdb:6KAU|rcsb pdb:4N7O|rcsb pdb:4N7P|rcsb pdb:6KAV|rcsb pdb:4N8T|rcsb pdb:6KYE|rcsb pdb:6L5V|rcsb pdb:6L5W|rcsb pdb:6L5X|rcsb pdb:6L5Y|rcsb pdb:6LCW|rcsb pdb:6LCX|rcsb pdb:4NI0|rcsb pdb:4NI1|rcsb pdb:4ROL|rcsb pdb:4ROM|rcsb pdb:4WJG|rcsb pdb:6NBC|rcsb pdb:6NBD|rcsb pdb:6NQ5|rcsb pdb:6TB2|rcsb pdb:6XD9|rcsb pdb:6XDT|rcsb pdb:6XE7|rcsb pdb:7AET|rcsb pdb:7AEV|rcsb pdb:7JJQ|rcsb pdb:7JXZ|rcsb pdb:7JY0|rcsb pdb:7JY1|rcsb pdb:7JY3|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-2168880|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:7AEU|refseq:NP_000508.1|refseq:NP_000549.1|rcsb pdb:1GBU|rcsb pdb:1GBV|rcsb pdb:1GLI|rcsb pdb:1GZX|rcsb pdb:1HAB|rcsb pdb:1HAC|rcsb pdb:1HBA|rcsb pdb:1HBB|rcsb pdb:1HBS|rcsb pdb:1HCO|rcsb pdb:1HDB|rcsb pdb:1HGA|rcsb pdb:1HGB|rcsb pdb:1HGC|rcsb pdb:1HHO|rcsb pdb:1IRD|rcsb pdb:1J3Y|rcsb pdb:1J3Z|rcsb pdb:1J40|rcsb pdb:1J41|rcsb pdb:1J7S|rcsb pdb:1J7W|rcsb pdb:1J7Y|rcsb pdb:1JY7|rcsb pdb:1K0Y|rcsb pdb:1K1K|rcsb pdb:1KD2|rcsb pdb:1LFL|rcsb pdb:1LFQ|rcsb pdb:1LFT|rcsb pdb:1LFV|rcsb pdb:1LFY|rcsb pdb:1LFZ|rcsb pdb:1LJW|rcsb pdb:1M9P|rcsb pdb:1MKO|rcsb pdb:1NEJ|rcsb pdb:1NIH|rcsb pdb:1NQP|rcsb pdb:1O1I|rcsb pdb:1O1J|rcsb pdb:1O1K|rcsb pdb:1O1L|rcsb pdb:1O1M|rcsb pdb:1O1N|rcsb pdb:1O1O|rcsb pdb:1O1P|rcsb pdb:1QI8|rcsb pdb:1QSH|rcsb pdb:1QSI|rcsb pdb:1QXD|rcsb pdb:1QXE|rcsb pdb:1R1X|rcsb pdb:1R1Y|rcsb pdb:1RPS|rcsb pdb:1RQ3|rcsb pdb:1RQ4|rcsb pdb:1RQA|rcsb pdb:1RVW|rcsb pdb:1SDK|rcsb pdb:1SDL|rcsb pdb:1SHR|rcsb pdb:1SI4|rcsb pdb:1THB|rcsb pdb:1UIW|rcsb pdb:1VWT|rcsb pdb:1XXT|rcsb pdb:1XY0|rcsb pdb:1XYE|rcsb pdb:1XZ2|rcsb pdb:1XZ4|rcsb pdb:1XZ5|rcsb pdb:1XZ7|rcsb pdb:1XZU|rcsb pdb:1XZV|rcsb pdb:1Y01|rcsb pdb:1Y09|rcsb pdb:1Y0A|rcsb pdb:1Y0C|rcsb pdb:1Y0D|rcsb pdb:1Y0T|rcsb pdb:1Y0W|rcsb pdb:1Y22|rcsb pdb:1Y2Z|rcsb pdb:1Y31|rcsb pdb:1Y35|rcsb pdb:1Y45|rcsb pdb:1Y46|rcsb pdb:1Y4B|rcsb pdb:1Y4F|rcsb pdb:1Y4G|rcsb pdb:1Y4P|rcsb pdb:1Y4Q|rcsb pdb:1Y4R|rcsb pdb:1Y4V|rcsb pdb:1Y5F|rcsb pdb:1Y5J|rcsb pdb:1Y5K|rcsb pdb:1Y7C|rcsb pdb:1Y7D|rcsb pdb:1Y7G|rcsb pdb:1Y7Z|rcsb pdb:1Y83|rcsb pdb:1Y85|rcsb pdb:1Y8W|rcsb pdb:1YDZ|rcsb pdb:1YE0|rcsb pdb:1YE1|rcsb pdb:1YE2|rcsb pdb:1YEN|rcsb pdb:1YEO|rcsb pdb:1YEQ|rcsb pdb:1YEU|rcsb pdb:1YEV|rcsb pdb:1YFF|rcsb pdb:1YG5|rcsb pdb:1YGD|rcsb pdb:1YGF|rcsb pdb:1YH9|rcsb pdb:1YHE|rcsb pdb:1YHR|rcsb pdb:1YIE|rcsb pdb:1YIH|dip:DIP-35199N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M4o0FF1DIrouBdyFXr4UtAlcjZw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25786	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359352|uniprotkb:Q9BRV9|uniprotkb:A8K400|uniprotkb:Q53YE8|ensembl:ENSP00000379676	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa1_human(display_long)|uniprotkb:PSMA1(gene name)|psi-mi:PSMA1(display_short)|uniprotkb:PROS30(gene name synonym)|uniprotkb:PSC2(gene name synonym)|uniprotkb:Proteasome component C2(gene name synonym)|uniprotkb:Macropain subunit C2(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C2(gene name synonym)|uniprotkb:Proteasome nu chain(gene name synonym)|uniprotkb:30 kDa prosomal protein(gene name synonym)|uniprotkb:HC2(gene name synonym)|uniprotkb:NU(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002777.1|refseq:NP_683877.1|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000129084(gene)|ensembl:ENST00000396394(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002376"(immune system process)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035144|mint:P25786|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|dip:DIP-29369N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tAADzZ1G9E/0BBeS8vybNx97v7k9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P29692	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358607|uniprotkb:Q969J1|uniprotkb:D3DWK3|intact:EBI-748782|uniprotkb:Q96I38|ensembl:ENSP00000317399|ensembl:ENSP00000378551|ensembl:ENSP00000388261|ensembl:ENSP00000433412|ensembl:ENSP00000433611|ensembl:ENSP00000434448|ensembl:ENSP00000434872|ensembl:ENSP00000436542|ensembl:ENSP00000436933|ensembl:ENSP00000478340|ensembl:ENSP00000479653|ensembl:ENSP00000483527|ensembl:ENSP00000487680|intact:EBI-11048966|uniprotkb:Q4VBZ6|uniprotkb:B4DDU4|uniprotkb:E9PBQ9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1d_human(display_long)|uniprotkb:EEF1D(gene name)|psi-mi:EEF1D(display_short)|uniprotkb:EF1D(gene name synonym)|uniprotkb:Antigen NY-CO-4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001123528.1|refseq:NP_001123527.1|refseq:NP_001123529.1|refseq:NP_001951.2|refseq:XP_011515207.1|refseq:XP_011515208.1|ensembl:ENST00000419152(transcript)|ensembl:ENST00000529272(transcript)|ensembl:ENST00000530191(transcript)|ensembl:ENST00000530445(transcript)|ensembl:ENST00000531218(transcript)|ensembl:ENST00000533494(transcript)|ensembl:ENST00000534380(transcript)|ensembl:ENST00000614575(transcript)|ensembl:ENST00000615067(transcript)|ensembl:ENST00000615698(transcript)|ensembl:ENST00000632587(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010941"(regulation of cell death)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045296"(cadherin binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219|mint:P29692|rcsb pdb:2MVM|rcsb pdb:2MVN|rcsb pdb:2N51|rcsb pdb:5JPO|reactome:R-HSA-156842|ensembl:ENSG00000104529(gene)|ensembl:ENSG00000273594(gene)|ensembl:ENST00000317198(transcript)|ensembl:ENST00000395119(transcript)|refseq:NP_001304672.1|refseq:NP_001182132.1|refseq:NP_001276879.1|refseq:XP_006716585.1|refseq:XP_006716586.1|refseq:XP_006716587.1|refseq:XP_006716588.1|refseq:XP_005250880.1|refseq:NP_001317575.1|refseq:XP_016868659.1|refseq:NP_001123525.2|refseq:NP_115754.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9Mzpfofeg2W/GQ/JfjFxcCFJnKg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06730	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73440|uniprotkb:Q96E95|ensembl:ENSP00000389624|uniprotkb:D6RCQ6|uniprotkb:B7Z6V1|intact:EBI-28969298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4e_human(display_long)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:EIF4E(gene name)|psi-mi:EIF4E(display_short)|uniprotkb:EIF4EL1(gene name synonym)|uniprotkb:EIF4F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001124151.1|refseq:NP_001959.1|ensembl:ENST00000280892|ensembl:ENSP00000280892|ensembl:ENSP00000389624|ensembl:ENST00000505992|ensembl:ENSP00000425561|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:2W97|rcsb pdb:3AM7|rcsb pdb:3TF2|rcsb pdb:3U7X|rcsb pdb:4AZA|rcsb pdb:4BEA|rcsb pdb:4DT6|rcsb pdb:4DUM|rcsb pdb:4TPW|rcsb pdb:4TQB|rcsb pdb:4TQC|rcsb pdb:4UED|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5EKV|rcsb pdb:5GW6|rcsb pdb:5T46|rcsb pdb:5ZJY|rcsb pdb:5ZJZ|rcsb pdb:5ZK5|rcsb pdb:5ZK7|rcsb pdb:5ZK9|ensembl:ENSG00000151247(gene)|rcsb pdb:5ZML|rcsb pdb:7MEU|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-159231|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-159230|reactome:R-HSA-159227|ensembl:ENST00000450253(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|mint:P06730|rcsb pdb:1IPB|rcsb pdb:1IPC|rcsb pdb:1WKW|rcsb pdb:2GPQ|rcsb pdb:2V8W|refseq:NP_001124150.1|refseq:NP_001317946.1|dip:DIP-22N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9173bxjOdBfKj36pWVvzw7M6g1A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y262	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96EP5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2133162|uniprotkb:Q96MJ3|uniprotkb:Q9NRR9|ensembl:ENSP00000233078	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dazp1_human(display_long)|uniprotkb:DAZAP1(gene name)|psi-mi:DAZAP1(display_short)|uniprotkb:Deleted in azoospermia-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061832.2|refseq:NP_733829.1|ensembl:ENSG00000071626(gene)|ensembl:ENST00000233078(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034046"("poly(G) binding")|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034131|interpro:IPR034134|interpro:IPR035979|mint:Q96EP5|rcsb pdb:2DGS|rcsb pdb:2DH8	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4uZCZTXZGnZAD9tBcurmc8RhGwY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60506	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1024357|uniprotkb:Q53H05|uniprotkb:Q5TCG2|uniprotkb:Q8IW78|uniprotkb:Q8N599|uniprotkb:Q96LC1|uniprotkb:Q96LC2|uniprotkb:Q9Y583|uniprotkb:Q5TCG3|uniprotkb:E1P501|uniprotkb:E1P502|ensembl:ENSP00000358635|ensembl:ENSP00000503783|ensembl:ENSP00000504706	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpq_human(display_long)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:SYNCRIP(gene name)|psi-mi:SYNCRIP(display_short)|uniprotkb:HNRPQ(gene name synonym)|uniprotkb:NSAP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153145.1|refseq:NP_001153146.1|refseq:NP_001153147.1|refseq:NP_001240700.1|refseq:NP_001153148.1|refseq:NP_001153149.1|refseq:NP_006363.4|ensembl:ENSG00000135316(gene)|ensembl:ENST00000369622(transcript)|ensembl:ENST00000676688(transcript)|ensembl:ENST00000678355(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:O60506|rcsb pdb:2DGU|rcsb pdb:2MXT|rcsb pdb:2NBB|rcsb pdb:6KOR|refseq:XP_016865667.1|refseq:XP_005248694.1|dip:DIP-35540N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2rDkXIp/wWzTOoVtN7Bd3uqZo689606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13492	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2803688|uniprotkb:Q86XZ9|uniprotkb:O60700|uniprotkb:Q6GMQ6|intact:EBI-28967113|ensembl:ENSP00000377015|uniprotkb:B4DTM3|uniprotkb:E9PN05|uniprotkb:F8VPG7|uniprotkb:Q4LE54	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pical_human(display_long)|uniprotkb:CALM(gene name synonym)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:PICALM(gene name)|psi-mi:PICALM(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000356360|ensembl:ENSP00000348718|ensembl:ENSP00000377015|ensembl:ENST00000526033|ensembl:ENSP00000433846|ensembl:ENST00000528398|ensembl:ENSP00000434884|ensembl:ENST00000532317|ensembl:ENSP00000436958|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0005634"(nucleus)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR030412|mint:Q13492|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9696264|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0032050"(clathrin heavy chain binding)|ensembl:ENSG00000073921(gene)|ensembl:ENST00000393346(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:0055072"(iron ion homeostasis)|refseq:NP_001008660.1|refseq:NP_001193875.1|refseq:NP_001193876.1|refseq:NP_009097.2|refseq:XP_005274388.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UIZhYyYqmBCyN4xwPCl9PeCdK8Q9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7L2E3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1211456|uniprotkb:O94965|uniprotkb:Q7Z753|uniprotkb:Q96CH4|uniprotkb:Q9NUQ0|uniprotkb:A8K5F1|ensembl:ENSP00000392601|ensembl:ENSP00000405620|intact:EBI-21350949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx30_human(display_long)|uniprotkb:DHX30(gene name)|psi-mi:DHX30(display_short)|uniprotkb:KIAA0890(gene name synonym)|uniprotkb:DDX30(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055781.2|refseq:NP_619520.1|refseq:XP_011531796.1|refseq:XP_011531797.1|refseq:XP_016861406.1|ensembl:ENSG00000132153(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007417"(central nervous system development)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q7L2E3|rcsb pdb:2DB2|ensembl:ENST00000445061(transcript)|ensembl:ENST00000446256(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tb4GzZKLycraXS0NlVqj8reV3IQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N1F7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042703|uniprotkb:Q14705|uniprotkb:B3KPQ8|ensembl:ENSP00000310668	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nup93_human(display_long)|uniprotkb:NUP93(gene name)|psi-mi:NUP93(display_short)|uniprotkb:KIAA0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055484.3|refseq:NP_001229724.1|refseq:NP_001229725.1|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8N1F7|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|ensembl:ENSG00000102900(gene)|reactome:R-HSA-168271|ensembl:ENST00000308159(transcript)|go:"GO:0005635"(nuclear envelope)|reactome:R-HSA-168276|go:"GO:0005643"(nuclear pore)|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-191859|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005256320.1|dip:DIP-44020N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pkk5pooUC4yQShpqjiwNLddfy149606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UKD2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1046493|ensembl:ENSP00000364320|uniprotkb:Q9BPV9|uniprotkb:Q5TG55|uniprotkb:Q96SS6|uniprotkb:B3KNB3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mrt4_human(display_long)|uniprotkb:MRTO4(gene name)|psi-mi:MRTO4(display_short)|uniprotkb:C1orf33(gene name synonym)|uniprotkb:MRT4(gene name synonym)|uniprotkb:Ribosome assembly factor MRTO4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000053372(gene)|ensembl:ENST00000330263(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:Q9UKD2|interpro:IPR033867|refseq:NP_057267.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LpvX3By1Cp6MxlAx3d5qoDM3FNY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96I24	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-954200|ensembl:ENSP00000318177|uniprotkb:Q92946|uniprotkb:Q9BVB6|intact:EBI-1760333|intact:EBI-1965411|uniprotkb:A3KFL0|uniprotkb:A3KFK8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp3_human(display_long)|uniprotkb:FUBP3(gene name)|psi-mi:FUBP3(display_short)|uniprotkb:FBP3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000107164(gene)|ensembl:ENST00000319725(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q96I24|refseq:NP_003925.1|dip:DIP-50124N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xdCa+teqFaSxKNTpCJWQ5gcd0sQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17096	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746843|uniprotkb:P10910|uniprotkb:Q9UKB0|uniprotkb:Q5T6U9|ensembl:ENSP00000308227|ensembl:ENSP00000399888	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmga1_human(display_long)|uniprotkb:High mobility group AT-hook protein 1(gene name synonym)|uniprotkb:HMGA1(gene name)|psi-mi:HMGA1(display_short)|uniprotkb:HMGIY(gene name synonym)|uniprotkb:High mobility group protein R(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002122.1|refseq:NP_665906.1|refseq:NP_665908.1|refseq:NP_665909.1|refseq:NP_665910.1|refseq:NP_665912.1|refseq:NP_001306006.1|refseq:NP_001306007.1|refseq:NP_001306008.1|refseq:NP_001306009.1|refseq:NP_001306010.1|refseq:NP_001306011.1|ensembl:ENSG00000137309(gene)|ensembl:ENST00000311487(transcript)|ensembl:ENST00000447654(transcript)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030527"(structural constituent of chromatin)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR000116(High mobility group, HMG-I and HMG-Y)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR017956|interpro:IPR031079|mint:P17096|rcsb pdb:2EZD|rcsb pdb:2EZE|rcsb pdb:2EZF|rcsb pdb:2EZG|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|reactome:R-HSA-2559584|dip:DIP-29687N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hhCMZ6CUf3e+PD0RNIauCZ8EThM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04792	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99848	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048111|uniprotkb:Q96A66|ensembl:ENSP00000236051	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ebp2_human(display_long)|uniprotkb:EBNA1-binding protein 2(gene name synonym)|uniprotkb:Nucleolar protein p40(gene name synonym)|uniprotkb:EBNA1BP2(gene name)|psi-mi:EBNA1BP2(display_short)|uniprotkb:EBP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153408.1|refseq:NP_006815.2|ensembl:ENSG00000117395(gene)|ensembl:ENST00000236051(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR008610(Eukaryotic rRNA processing)|mint:Q99848|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lUFbxBko/pJHiNq8uuefmK3Xqp89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02545	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-395393|uniprotkb:P08918|uniprotkb:P08919|uniprotkb:Q14860|uniprotkb:Q16295|ensembl:ENSP00000266732	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lap2a_human(display_long)|uniprotkb:TMPO(gene name)|psi-mi:TMPO(display_short)|uniprotkb:LAP2(gene name synonym)|uniprotkb:Thymopoietin isoform alpha(gene name synonym)|uniprotkb:Thymopoietin-related peptide isoform alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003267.1|ensembl:ENSG00000120802(gene)|ensembl:ENST00000266732(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0045296"(cadherin binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR013146(Thymopoietin LEM)|interpro:IPR021623|mint:P42166|rcsb pdb:1GJJ|rcsb pdb:1H9E|rcsb pdb:1H9F	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/kq+6sQN9B8jf+Ee4uPj7gtWe509606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50570	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96AG4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358888|uniprotkb:Q9P189|uniprotkb:D3DTX8|ensembl:ENSP00000225972|uniprotkb:B2RE83	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lrc59_human(display_long)|uniprotkb:LRRC59(gene name)|psi-mi:LRRC59(display_short)|uniprotkb:Ribosome-binding protein p34(gene name synonym)|uniprotkb:PRO1855(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060979.2|ensembl:ENSG00000108829(gene)|ensembl:ENST00000225972(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045296"(cadherin binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q96AG4	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gAtWed9Jv69oHdkEFgpWGFnvcWE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75694	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050769|uniprotkb:Q9UBE9|uniprotkb:Q9UFL5|intact:EBI-28983292|ensembl:ENSP00000231498	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu155_human(display_long)|uniprotkb:Nucleoporin Nup155(gene name synonym)|uniprotkb:155 kDa nucleoporin(gene name synonym)|uniprotkb:KIAA0791(gene name synonym)|uniprotkb:NUP155(gene name)|psi-mi:NUP155(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004289.1|refseq:NP_705618.1|ensembl:ENSP00000231498|ensembl:ENST00000381843|ensembl:ENSP00000371265|ensembl:ENSG00000113569(gene)|ensembl:ENST00000231498(transcript)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036228"(protein localization to nuclear inner membrane)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|interpro:IPR004870(Nucleoporin, non-repetitive/WGA-negative)|interpro:IPR007187(Nucleoporin, Nup133-like, C-terminal)|interpro:IPR014908(Nup133, N-terminal)|interpro:IPR042533|interpro:IPR042537|interpro:IPR042538|rcsb pdb:5A9Q|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k6LjWvJdqtT78G4Wu12rJX/2WHo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BQG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-676973|intact:EBI-2559619|uniprotkb:Q86VM3|uniprotkb:Q9BW49|uniprotkb:Q9P0V5|uniprotkb:Q9UF99|ensembl:ENSP00000254718	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mbb1a_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)|uniprotkb:P160(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001099008.1|refseq:NP_055335.2|ensembl:ENST00000254718(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|ensembl:ENSG00000132382(gene)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q9BQG0|reactome:R-HSA-5250924	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ScabTPXvbX/5VRsnaRQXUIlANow9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69891	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056789|uniprotkb:P02096|uniprotkb:P62027|uniprotkb:Q96FH7|uniprotkb:Q8TDA1|uniprotkb:Q549G1|ensembl:ENSP00000327431	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg1_human(display_long)|uniprotkb:HBG1(gene name)|psi-mi:HBG1(display_short)|uniprotkb:Hemoglobin gamma-1 chain(gene name synonym)|uniprotkb:Gamma-1-globin(gene name synonym)|uniprotkb:Hemoglobin gamma-A chain(gene name synonym)|uniprotkb:Hb F Agamma(gene name synonym)|uniprotkb:PRO2979(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000550.2|ensembl:ENSG00000213934(gene)|ensembl:ENST00000330597(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1I3D|rcsb pdb:1I3E|reactome:R-HSA-983231	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iJ4HIirEDw3t7jxBcbZLma4HgXE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00839	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92900	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373471|uniprotkb:O00239|uniprotkb:O43343|uniprotkb:Q86Z25|uniprotkb:Q92842|ensembl:ENSP00000470142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rent1_human(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:RENT1(gene name synonym)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002902.2|refseq:NP_001284478.1|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000599848(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q92900|rcsb pdb:2GJK|rcsb pdb:2GK6|rcsb pdb:2GK7|rcsb pdb:2IYK|rcsb pdb:2WJV|rcsb pdb:2WJY|rcsb pdb:2XZO|rcsb pdb:2XZP|rcsb pdb:6EJ5|rcsb pdb:6Z3R|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0006406"(mRNA export from nucleus)|dip:DIP-29875N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ORqXFPAa7qA8cwM5qcNodIF0q/s9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43684	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050987|uniprotkb:O43685|uniprotkb:B2R6E7|uniprotkb:A6NJ42|uniprotkb:D3DRE9|ensembl:ENSP00000357858	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bub3_human(display_long)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001007794.1|refseq:NP_004716.1|ensembl:ENSG00000154473(gene)|ensembl:ENST00000368865(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR020472|interpro:IPR036322|mint:O43684|reactome:R-HSA-141430|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|dip:DIP-24205N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nqzARPql2cThSUpxSb6PuTRn51E9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BWF3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2856454|uniprotkb:B3KUN0|uniprotkb:Q8WU85|uniprotkb:Q6P1P2|uniprotkb:O02916|uniprotkb:Q4VC48|uniprotkb:B4E1U0|uniprotkb:E7EQS3|ensembl:ENSP00000309166|ensembl:ENSP00000386561|ensembl:ENSP00000386894	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm4_human(display_long)|uniprotkb:RBM4(gene name)|psi-mi:RBM4(display_short)|uniprotkb:RBM4A(gene name synonym)|uniprotkb:Lark homolog(gene name synonym)|uniprotkb:RNA-binding motif protein 4(gene name synonym)|uniprotkb:RNA-binding motif protein 4a(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001185772.1|refseq:NP_002887.2|refseq:NP_001185773.1|dip:DIP-44199N|ensembl:ENSG00000173933(gene)|ensembl:ENST00000310092(transcript)|ensembl:ENST00000408993(transcript)|ensembl:ENST00000409406(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002190"(cap-independent translational initiation)|go:"GO:0002192"(IRES-dependent translational initiation of linear mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0097158"(pre-mRNA intronic pyrimidine-rich binding)|go:"GO:0097167"(circadian regulation of translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR034897|interpro:IPR034898|interpro:IPR035979|mint:Q9BWF3|rcsb pdb:2DNQ|reactome:R-HSA-400253|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hbW6dv/AEWQz3mWvA2/9n8h/bbA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15717	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374260|uniprotkb:Q9BTT1|ensembl:ENSP00000385269|ensembl:ENSP00000472197|intact:EBI-6190219|uniprotkb:B4DVB8|uniprotkb:Q53XN6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:elav1_human(display_long)|uniprotkb:ELAVL1(gene name)|psi-mi:ELAVL1(display_short)|uniprotkb:HUR(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|ensembl:ENSG00000066044(gene)|ensembl:ENST00000407627(transcript)|ensembl:ENST00000596459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|refseq:NP_001410.2|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:Q15717|rcsb pdb:3HI9|rcsb pdb:4ED5|rcsb pdb:4EGL|rcsb pdb:4FXV|rcsb pdb:5SZW|rcsb pdb:6G2K|rcsb pdb:6GC5|rcsb pdb:6GD1|rcsb pdb:6GD2|rcsb pdb:6GD3|reactome:R-HSA-450520|reactome:R-HSA-72163|dip:DIP-31291N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PciL5KuvP+2aUUv9cv7gWScgbw89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13247	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745230|uniprotkb:Q13244|uniprotkb:Q13245|uniprotkb:Q96J06|uniprotkb:Q9UJB8|uniprotkb:Q9Y3N7|uniprotkb:B7Z6J3|uniprotkb:E1P5W6|ensembl:ENSP00000244020	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf6_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP55(gene name synonym)|uniprotkb:SRSF6(gene name)|psi-mi:SRSF6(display_short)|uniprotkb:SRP55(gene name synonym)|uniprotkb:SFRS6(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006266.2|ensembl:ENSG00000124193(gene)|ensembl:ENST00000244020(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0032868"(response to insulin)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0045617"(negative regulation of keratinocyte differentiation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061041"(regulation of wound healing)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029541|interpro:IPR034511|interpro:IPR035979|mint:Q13247|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vU4nobP3g/hsgnll0mQgjJcME2k9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99613	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P20700	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-968218|ensembl:ENSP00000261366|uniprotkb:Q3SYN7|uniprotkb:Q96EI6|uniprotkb:B2R6J6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lmnb1_human(display_long)|uniprotkb:LMNB1(gene name)|psi-mi:LMNB1(display_short)|uniprotkb:LMN2(gene name synonym)|uniprotkb:LMNB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000113368(gene)|ensembl:ENST00000261366(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P20700|rcsb pdb:2KPW|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3JT0|rcsb pdb:3TYY|rcsb pdb:3UMN|rcsb pdb:5VVX|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|reactome:R-HSA-2559584|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-4419969|reactome:R-HSA-8862803|reactome:R-HSA-8950505|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:NP_005564.1|dip:DIP-34897N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZLv4OS5VSmn3sdXB9IP98YdQ+Iw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78527	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-744603|uniprotkb:Q14818|uniprotkb:Q14819|uniprotkb:Q15913|uniprotkb:Q8IY00|uniprotkb:Q92744|uniprotkb:Q92745|uniprotkb:Q969H7|uniprotkb:Q9BW01|uniprotkb:Q9UEI0|uniprotkb:B7Z1Q1|uniprotkb:C9JJE2|ensembl:ENSP00000366607	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf01_human(display_long)|uniprotkb:Zinc finger protein 162(gene name synonym)|uniprotkb:Transcription factor ZFM1(gene name synonym)|uniprotkb:Zinc finger gene in MEN1 locus(gene name synonym)|uniprotkb:Mammalian branch point-binding protein(gene name synonym)|uniprotkb:SF1(gene name)|psi-mi:SF1(display_short)|uniprotkb:ZFM1(gene name synonym)|uniprotkb:ZNF162(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001171501.1|refseq:NP_001171502.1|refseq:NP_004621.2|refseq:NP_973724.1|refseq:NP_973727.1|rcsb pdb:4FXX|rcsb pdb:4FXW|reactome:R-HSA-72163|refseq:XP_016873733.1|ensembl:ENSG00000168066(gene)|ensembl:ENST00000377390(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005840"(ribosome)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030238"(male sex determination)|go:"GO:0030575"(nuclear body organization)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045131"(pre-mRNA branch point binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR031150|interpro:IPR032570|interpro:IPR036612|mint:Q15637|rcsb pdb:1K1G|rcsb pdb:1O0P|rcsb pdb:1OPI|rcsb pdb:2M09|rcsb pdb:2M0G|refseq:NP_001333292.1|refseq:NP_001333293.1|dip:DIP-29410N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N4k5Rvc5EDsSJt50J4ojje9p0249606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NR30	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357942|uniprotkb:Q13436|uniprotkb:Q5VX41|uniprotkb:Q68D35|uniprotkb:B2RDL0|intact:EBI-2555822|ensembl:ENSP00000346120	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx21_human(display_long)|uniprotkb:DDX21(gene name)|psi-mi:DDX21(display_short)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004719.2|dip:DIP-32941N|refseq:NP_001243839.1|ensembl:ENSG00000165732(gene)|ensembl:ENST00000354185(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9NR30|rcsb pdb:2M3D|rcsb pdb:6L5L|rcsb pdb:6L5M|rcsb pdb:6L5N|rcsb pdb:6L5O|reactome:R-HSA-5250924|reactome:R-HSA-6791226|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NSmxvs3DBWvKpVDEAHIpqy7/b6w9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43390	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713419|uniprotkb:S4R3J4|uniprotkb:Q5TEH1|ensembl:ENSP00000304405|ensembl:ENSP00000363741|ensembl:ENSP00000489252|ensembl:ENSP00000489371|uniprotkb:Q9BV64|uniprotkb:Q2L7G6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpr_human(display_long)|uniprotkb:HNRPR(gene name synonym)|uniprotkb:HNRNPR(gene name)|psi-mi:HNRNPR(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001095868.1|refseq:XP_005245768.1|ensembl:ENSG00000125944(gene)|ensembl:ENSG00000282958(gene)|ensembl:ENST00000302271(transcript)|ensembl:ENST00000374612(transcript)|ensembl:ENST00000634263(transcript)|ensembl:ENST00000634766(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043679"(axon terminus)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034411|interpro:IPR035979|mint:O43390|rcsb pdb:2DK2|reactome:R-HSA-72163|reactome:R-HSA-72203|interpro:IPR041337|refseq:NP_005817.1|refseq:XP_011538773.1|refseq:NP_001284549.1|refseq:XP_016855497.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UiOaRbnMd1S2FthR4RWltyq6xT49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92614	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-949059|ensembl:ENSP00000437073|uniprotkb:Q5H9U3|uniprotkb:Q5W9F9|uniprotkb:Q5W9G1|uniprotkb:Q8IXP8|uniprotkb:Q5QD01	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:my18a_human(display_long)|uniprotkb:Myosin containing a PDZ domain(gene name synonym)|uniprotkb:Molecule associated with JAK3 N-terminus(gene name synonym)|uniprotkb:MYO18A(gene name)|psi-mi:MYO18A(display_short)|uniprotkb:KIAA0216(gene name synonym)|uniprotkb:MYSPDZ(gene name synonym)|uniprotkb:CD245(gene name synonym)|uniprotkb:Surfactant protein receptor SP-R210(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	dip:DIP-46631N|ensembl:ENSG00000196535(gene)|ensembl:ENST00000527372(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016477"(cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042641"(actomyosin)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|go:"GO:1903028"(positive regulation of opsonization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR020587|interpro:IPR027417|interpro:IPR031244|interpro:IPR036034|interpro:IPR036064|interpro:IPR036961|interpro:IPR041489|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-9703465|refseq:NP_510880.2|refseq:NP_976063.1|refseq:NP_001333696.1|refseq:NP_001333697.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IunEYt79RO62wU6VU2gv16Xb7Lk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02100	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190240|ensembl:ENSP00000292896|ensembl:ENSP00000369586|ensembl:ENSP00000380104|uniprotkb:Q6FH44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbe_human(display_long)|uniprotkb:HBE1(gene name)|psi-mi:HBE1(display_short)|uniprotkb:HBE(gene name synonym)|uniprotkb:Epsilon-globin(gene name synonym)|uniprotkb:Hemoglobin epsilon chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000213931(gene)|ensembl:ENST00000292896(transcript)|ensembl:ENST00000380237(transcript)|ensembl:ENST00000396895(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1A9W|reactome:R-HSA-983231|refseq:NP_005321.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZKgpsS0AFjNRaxSJ4ctde2ESHik9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96PK6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-954272|ensembl:ENSP00000311747|uniprotkb:O75932|uniprotkb:Q53GV1|uniprotkb:Q68DQ9|uniprotkb:Q96PK5|uniprotkb:B3KMN4|uniprotkb:Q2PYN1|uniprotkb:D6RGD8|uniprotkb:B0LM41|intact:EBI-16430855|intact:EBI-16472484	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm14_human(display_long)|uniprotkb:RNA-binding motif protein 14(gene name synonym)|uniprotkb:RRM-containing coactivator activator/modulator(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein(gene name synonym)|uniprotkb:RBM14(gene name)|psi-mi:RBM14(display_short)|uniprotkb:SIP(gene name synonym)|uniprotkb:Paraspeckle protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000239306(gene)|ensembl:ENST00000310137(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009725"(response to hormone)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034506|interpro:IPR034507|go:"GO:0098534"(centriole assembly)|interpro:IPR035979|mint:Q96PK6|rcsb pdb:2DNP|reactome:R-HSA-8941326|refseq:NP_001185765.1|refseq:NP_006319.1|ensembl:ENSP00000311747|ensembl:ENST00000393979|ensembl:ENSP00000377548|ensembl:ENST00000409738|ensembl:ENSP00000386995|refseq:NP_001185766.1|refseq:NP_001185774.1|dip:DIP-50126N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Q0UBl2qmfwQTPwUQ7ZDwGIMOYoA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14204	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62826	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26358	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60493	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727209|uniprotkb:Q4TT31|uniprotkb:O60718|uniprotkb:Q5JXJ7|uniprotkb:Q5JXJ8|uniprotkb:Q96AP9|uniprotkb:Q9C0J5|uniprotkb:Q9NU45|intact:EBI-1056609|uniprotkb:A8K0B1|uniprotkb:Q4TT29|uniprotkb:E1P5E4|uniprotkb:E1P5E5|ensembl:ENSP00000230085	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snx3_human(display_long)|uniprotkb:Protein SDP3(gene name synonym)|uniprotkb:SNX3(gene name)|psi-mi:SNX3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003786.1|refseq:NP_690040.1|refseq:NP_001287858.1|ensembl:ENSG00000112335(gene)|ensembl:ENST00000230085(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1905394"(retromer complex binding)|go:"GO:2000642"(negative regulation of early endosome to late endosome transport)|interpro:IPR001683(Phox-like)|interpro:IPR036871|interpro:IPR042137|rcsb pdb:2MXC|rcsb pdb:2YPS|rcsb pdb:5F0J|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:7BLO|reactome:R-HSA-3238698|reactome:R-HSA-5689880	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M/QKs79zhWobkEdFuxrJTnrrUes9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05198	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056162|ensembl:ENSP00000256383|ensembl:ENSP00000425299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2a_human(display_long)|uniprotkb:EIF2S1(gene name)|psi-mi:EIF2S1(display_short)|uniprotkb:EIF2A(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004085.1|ensembl:ENSG00000134001(gene)|ensembl:ENST00000256383(transcript)|ensembl:ENST00000466499(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|mint:P05198|rcsb pdb:1KL9|rcsb pdb:1Q8K|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|dip:DIP-39418N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hG3fLbQuFpe5z8zS/bt/TnpEpzA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P41252	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355303|uniprotkb:Q5TCD0|uniprotkb:Q9H588|uniprotkb:A8KAE9|uniprotkb:Q7Z3T4|ensembl:ENSP00000364794|ensembl:ENSP00000406448|ensembl:ENSP00000507144	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syic_human(display_long)|uniprotkb:IARS1(gene name)|psi-mi:IARS1(display_short)|uniprotkb:IARS(gene name synonym)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002152.2|refseq:NP_038203.2|ensembl:ENSG00000196305(gene)|ensembl:ENST00000375643(transcript)|ensembl:ENST00000443024(transcript)|ensembl:ENST00000683565(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023586|interpro:IPR033709|mint:P41252|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:maAJX/O1Ryxr5NVFQEWvXNgHXyY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15357	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28482	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-959949|ensembl:ENSP00000215832|ensembl:ENSP00000381803|uniprotkb:A8CZ64	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mk01_human(display_long)|uniprotkb:MAPK1(gene name)|psi-mi:MAPK1(display_short)|uniprotkb:ERK2(gene name synonym)|uniprotkb:PRKM1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)|uniprotkb:PRKM2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-112411|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-437239|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|refseq:NP_002736.3|refseq:NP_620407.1|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P28482|rcsb pdb:1PME|go:"GO:0072686"(mitotic spindle)|rcsb pdb:1TVO|rcsb pdb:1WZY|rcsb pdb:2OJG|rcsb pdb:2OJI|rcsb pdb:2OJJ|rcsb pdb:2Y9Q|rcsb pdb:3D42|rcsb pdb:3D44|rcsb pdb:3I5Z|rcsb pdb:3I60|rcsb pdb:3SA0|rcsb pdb:3TEI|rcsb pdb:3W55|rcsb pdb:4FMQ|rcsb pdb:4FUX|rcsb pdb:4FUY|rcsb pdb:4FV0|rcsb pdb:4FV1|rcsb pdb:4FV2|rcsb pdb:4FV3|rcsb pdb:4FV4|rcsb pdb:4FV5|rcsb pdb:4FV6|rcsb pdb:4FV7|rcsb pdb:4FV8|rcsb pdb:4FV9|rcsb pdb:4G6N|rcsb pdb:4G6O|rcsb pdb:4H3P|rcsb pdb:4H3Q|rcsb pdb:4IZ5|rcsb pdb:4IZ7|rcsb pdb:4IZA|rcsb pdb:4N0S|rcsb pdb:4NIF|rcsb pdb:4O6E|rcsb pdb:4QP1|rcsb pdb:4QP2|rcsb pdb:4QP3|rcsb pdb:4QP4|rcsb pdb:4QP6|rcsb pdb:4QP7|rcsb pdb:4QP8|rcsb pdb:4QP9|rcsb pdb:4QPA|rcsb pdb:4QTA|rcsb pdb:4QTE|rcsb pdb:4XJ0|rcsb pdb:4ZXT|rcsb pdb:4ZZM|rcsb pdb:4ZZN|rcsb pdb:4ZZO|rcsb pdb:5AX3|rcsb pdb:5BUE|rcsb pdb:5BUI|rcsb pdb:5BUJ|rcsb pdb:5BVD|rcsb pdb:5BVE|rcsb pdb:5BVF|rcsb pdb:5K4I|rcsb pdb:5LCJ|rcsb pdb:5LCK|rcsb pdb:5NGU|rcsb pdb:5NHF|rcsb pdb:5NHH|rcsb pdb:5NHJ|rcsb pdb:5NHL|rcsb pdb:5NHO|rcsb pdb:5NHP|rcsb pdb:5NHV|rcsb pdb:5V60|rcsb pdb:5V61|rcsb pdb:5V62|rcsb pdb:5WP1|rcsb pdb:6D5Y|rcsb pdb:6DMG|rcsb pdb:6G54|rcsb pdb:6G8X|rcsb pdb:6G91|rcsb pdb:6G92|rcsb pdb:6G93|rcsb pdb:6G97|rcsb pdb:6G9A|rcsb pdb:6G9D|rcsb pdb:6G9H|rcsb pdb:6G9J|rcsb pdb:6G9K|rcsb pdb:6G9M|rcsb pdb:6G9N|rcsb pdb:6GDM|rcsb pdb:6GDQ|rcsb pdb:6GE0|rcsb pdb:6GJB|rcsb pdb:6GJD|rcsb pdb:6NBS|rcsb pdb:6OPG|rcsb pdb:6OPH|rcsb pdb:6OPI|rcsb pdb:6Q7K|rcsb pdb:6Q7S|rcsb pdb:6Q7T|rcsb pdb:6QA1|rcsb pdb:6QA3|rcsb pdb:6QA4|rcsb pdb:6QAG|rcsb pdb:6QAH|rcsb pdb:6QAL|rcsb pdb:6QAQ|rcsb pdb:6QAW|rcsb pdb:6RQ4|rcsb pdb:6SLG|reactome:R-HSA-111995|reactome:R-HSA-112409|ensembl:ENSG00000100030(gene)|ensembl:ENST00000215832(transcript)|ensembl:ENST00000398822(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634635|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9652817|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|dip:DIP-519N|ensembl:ENSP00000215832|ensembl:ENSP00000381803|ensembl:ENST00000544786|ensembl:ENSP00000440842	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:odzhd70I/8uWedx0+gF38lhe60I9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52272	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047080|uniprotkb:Q15074|intact:EBI-1171814|uniprotkb:Q6IMN4|uniprotkb:A6NMY7|uniprotkb:Q6IMN7|uniprotkb:Q9BV09|intact:EBI-2562858|intact:EBI-3449178|uniprotkb:D3DR06|ensembl:ENSP00000340329|ensembl:ENSP00000434150	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:capr1_human(display_long)|uniprotkb:CAPRIN1(gene name)|psi-mi:CAPRIN1(display_short)|uniprotkb:GPIAP1(gene name synonym)|uniprotkb:GPIP137(gene name synonym)|uniprotkb:M11S1(gene name synonym)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Cell cycle-associated protein 1(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:RNG105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005889.3|refseq:NP_976240.1|ensembl:ENSG00000135387(gene)|ensembl:ENST00000341394(transcript)|ensembl:ENST00000532820(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q14444|rcsb pdb:4WBE|rcsb pdb:4WBP|rcsb pdb:6TA7|refseq:XP_016873238.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3c6ZdBClP/D6jIi8NfzBkMc61pI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22681	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14152	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15181	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712298|ensembl:ENSP00000362329|uniprotkb:Q2M348|uniprotkb:Q5SQT7|uniprotkb:Q6P7P4|uniprotkb:Q9UQJ5|uniprotkb:Q9Y5B1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipyr_human(display_long)|uniprotkb:Pyrophosphate phospho-hydrolase(gene name synonym)|uniprotkb:PPA1(gene name)|psi-mi:PPA1(display_short)|uniprotkb:IOPPP(gene name synonym)|uniprotkb:PP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000180817(gene)|ensembl:ENST00000373232(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008162(Inorganic pyrophosphatase)|interpro:IPR036649|mint:Q15181|rcsb pdb:6C45|rcsb pdb:7BTN|rcsb pdb:7CMO|reactome:R-HSA-379716|reactome:R-HSA-71737|refseq:NP_066952.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1094gn9aeisgfDUhIroRn2iqom49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46109	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14866	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719024|uniprotkb:Q9H3P3|uniprotkb:A6ND69|uniprotkb:A6NIT8|ensembl:ENSP00000221419|ensembl:ENSP00000489021	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpl_human(display_long)|uniprotkb:HNRPL(gene name synonym)|uniprotkb:HNRNPL(gene name)|psi-mi:HNRNPL(display_short)|uniprotkb:P/OKcl.14(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001005335.1|refseq:NP_001524.2|refseq:XP_011525191.1|ensembl:ENSG00000282947(gene)|ensembl:ENST00000221419(transcript)|ensembl:ENST00000634753(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097157"(pre-mRNA intronic binding)|ensembl:ENSG00000104824(gene)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979|mint:P14866|rcsb pdb:3R27|rcsb pdb:3TO8|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:1990904"(ribonucleoprotein complex)|dip:DIP-36355N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vOfznm03e6Ottg6BptYHmR9qJEc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P45880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:seQxCd19Z2HmpXcwb48osAuuafA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N684	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746909|uniprotkb:C9K0Q4|uniprotkb:Q7Z3H9|uniprotkb:Q9H025|uniprotkb:Q9H9V1|uniprotkb:B3KU04|ensembl:ENSP00000378352	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpsf7_human(display_long)|uniprotkb:Cleavage and polyadenylation specificity factor 59 kDa subunit(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 59 kDa subunit(gene name synonym)|uniprotkb:CPSF7(gene name)|psi-mi:CPSF7(display_short)|uniprotkb:Cleavage factor Im complex 59 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129512.1|refseq:NP_001136037.1|refseq:NP_079087.3|refseq:XP_011543560.1|refseq:XP_011543561.1|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0016020"(membrane)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034770|interpro:IPR034772|interpro:IPR034773|interpro:IPR035979|mint:Q8N684|rcsb pdb:3N9U|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|ensembl:ENSG00000149532(gene)|ensembl:ENST00000394888(transcript)|refseq:XP_005274356.1|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfliZhw27GRZMSQpYRZ/x/tWGh49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13224	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2833037|uniprotkb:Q8NG40|uniprotkb:Q14422|ensembl:ENSP00000383382	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gp1bb_human(display_long)|uniprotkb:GP1BB(gene name)|psi-mi:GP1BB(display_short)|uniprotkb:Antigen CD42b-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000398.1|ensembl:ENSG00000203618(gene)|ensembl:ENST00000366425(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0042802"(identical protein binding)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR032675|mint:P13224|rcsb pdb:3REZ|rcsb pdb:3RFE|reactome:R-HSA-140837|reactome:R-HSA-430116|reactome:R-HSA-75892|reactome:R-HSA-76009|reactome:R-HSA-9673221	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eD4E+gbGDmXWJhX5W8jNjLLy0d89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UBQ5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13310	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372844|uniprotkb:Q6P0N3|uniprotkb:B1ANQ8|ensembl:ENSP00000361948|intact:EBI-877641|uniprotkb:Q4VC03	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pabp4_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:APP1(gene name synonym)|uniprotkb:PABP4(gene name synonym)|uniprotkb:"Inducible poly(A)-binding protein"(gene name synonym)|uniprotkb:Activated-platelet protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129126.1|refseq:NP_003810.1|ensembl:ENSG00000090621(gene)|ensembl:ENST00000372857(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006412"(translation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0061515"(myeloid cell development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q13310|refseq:NP_001129125.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u1qCM3o5X7jLIa1vyqFCIH7v01w9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B7Z5V2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190263	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b7z5v2_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0042995"(cell projection)|interpro:IPR019749|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019747|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018980|interpro:IPR008954(Moesin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+vK2a20sO9KEUDpPbszDHGxJpOA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08238	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wOsW7C10v2oMsM+REE38K6PAan09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95373	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11940	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XudTSPq2h9ckKAc48X88RVafPRU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16695	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31943	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43175	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5A9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2878081|uniprotkb:B4E1G7|uniprotkb:A6NKG4|uniprotkb:Q5VSZ9|uniprotkb:Q8TDH0|uniprotkb:Q9BUJ5|uniprotkb:A8K966|uniprotkb:D3DPM8|ensembl:ENSP00000362918|ensembl:ENSP00000444660	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ythd2_human(display_long)|uniprotkb:HGRG8(gene name synonym)|uniprotkb:CLL-associated antigen KW-14(gene name synonym)|uniprotkb:High-glucose-regulated protein 8(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-2(gene name synonym)|uniprotkb:YTHDF2(gene name)|psi-mi:YTHDF2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001166299.1|refseq:NP_001166599.1|refseq:NP_057342.2|ensembl:ENSG00000198492(gene)|ensembl:ENST00000373812(transcript)|ensembl:ENST00000542507(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045087"(innate immune response)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070925"(organelle assembly)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:2000232"(regulation of rRNA processing)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR007275(YT521-B-like protein)|mint:Q9Y5A9|rcsb pdb:4RDO|rcsb pdb:4WQN|rcsb pdb:4RDN	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PF4C2t/728HqnrTyBQDJydH0G709606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92841	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746012|uniprotkb:Q69YT1|uniprotkb:Q6ICD6|uniprotkb:H3BLZ8|uniprotkb:B1AHM0|ensembl:ENSP00000385536	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx17_human(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:RNA-dependent helicase p72(gene name synonym)|uniprotkb:DEAD box protein p72(gene name synonym)|uniprotkb:DDX17(gene name)|psi-mi:DDX17(display_short)|uniprotkb:DEAD box protein p82(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006377.2|ensembl:ENSG00000100201(gene)|ensembl:ENST00000403230(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q92841|rcsb pdb:6UV0|rcsb pdb:6UV1|rcsb pdb:6UV2|rcsb pdb:6UV3|rcsb pdb:6UV4|reactome:R-HSA-3899300|dip:DIP-29843N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3UhUuhRSZg/zlM7UPDKYCqNmUho9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13347	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354047|intact:EBI-11759480|ensembl:ENSP00000504034|ensembl:ENSP00000504061|ensembl:ENSP00000502867|ensembl:ENSP00000503348|ensembl:ENSP00000503539	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3i_human(display_long)|uniprotkb:EIF3I(gene name)|psi-mi:EIF3I(display_short)|uniprotkb:TRIP1(gene name synonym)|uniprotkb:EIF3S2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 2(gene name synonym)|uniprotkb:eIF-3-beta(gene name synonym)|uniprotkb:eIF3 p36(gene name synonym)|uniprotkb:TGF-beta receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003748.1|ensembl:ENST00000676801(transcript)|ensembl:ENST00000677202(transcript)|ensembl:ENST00000677701(transcript)|ensembl:ENST00000677711(transcript)|ensembl:ENST00000677760(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|ensembl:ENSG00000084623(gene)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027525|interpro:IPR036322|mint:Q13347|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31116N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fogC6nSNmIynV2ziHZboT9laA3M9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04406	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15056	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748492|uniprotkb:A8K3R1|uniprotkb:D3DXF6|uniprotkb:D3DXF8|ensembl:ENSP00000265753	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4h_human(display_long)|uniprotkb:Williams-Beuren syndrome chromosomal region 1 protein(gene name synonym)|uniprotkb:EIF4H(gene name)|psi-mi:EIF4H(display_short)|uniprotkb:WBSCR1(gene name synonym)|uniprotkb:KIAA0038(gene name synonym)|uniprotkb:WSCR1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_071496.1|refseq:NP_114381.1|ensembl:ENSG00000106682(gene)|ensembl:ENST00000265753(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0019953"(sexual reproduction)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034057"(RNA strand-exchange activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048589"(developmental growth)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034229|interpro:IPR035979|mint:Q15056|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dNPoAzwFD5lFwCMnRl0cbXM3j8s9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12931	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8TC07	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048247|uniprotkb:B9A6L6|intact:EBI-6190229|uniprotkb:B4DMT9|uniprotkb:J3KNI9|uniprotkb:Q9HA83|intact:EBI-28984447|ensembl:ENSP00000448182	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbc15_human(display_long)|uniprotkb:TBC1D15(gene name)|psi-mi:TBC1D15(display_short)|uniprotkb:GTPase-activating protein RAB7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001139685.2|refseq:NP_001139686.1|refseq:NP_073608.4|ensembl:ENST00000319106|ensembl:ENSP00000318262|ensembl:ENST00000485960|ensembl:ENSP00000420678|ensembl:ENSP00000448182|ensembl:ENSG00000121749(gene)|ensembl:ENST00000550746(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3tlqjLtZ/Bq5H6M00sHIwqNqqw49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237119|uniprotkb:Q52LW9|uniprotkb:B2R5A3|ensembl:ENSP00000366618	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h2b1l_human(display_long)|uniprotkb:H2BC13(gene name)|psi-mi:H2BC13(display_short)|uniprotkb:H2BFC(gene name synonym)|uniprotkb:HIST1H2BL(gene name synonym)|uniprotkb:Histone H2B.c(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003510.1|dip:DIP-38154N|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|ensembl:ENSG00000185130(gene)|ensembl:ENST00000377401(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|interpro:IPR009072(Histone-fold)|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5250924|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vVD3xoHavMKCopzEez7zarZBKFc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38159	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-743526|ensembl:ENSP00000359645|uniprotkb:Q5JQ67|uniprotkb:Q969R3|uniprotkb:D3DWH0|uniprotkb:E9PG86|uniprotkb:Q8N8Y7|uniprotkb:B4E3U4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbmx_human(display_long)|uniprotkb:Glycoprotein p43(gene name synonym)|uniprotkb:RBMX(gene name)|psi-mi:RBMX(display_short)|uniprotkb:HNRPG(gene name synonym)|uniprotkb:RBMXP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein G(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000147274(gene)|ensembl:ENST00000320676(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012604(RBM1CTR)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P38159|rcsb pdb:2MB0|rcsb pdb:2MKS|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:NP_002130.2|refseq:NP_001158275.1|dip:DIP-34447N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ocCkdy9PxjeVLUQf0tMVCEhFfO89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60231	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-311446|uniprotkb:O60322|uniprotkb:Q969X7|uniprotkb:Q96QC1|uniprotkb:Q5JP45|ensembl:ENSP00000365625|ensembl:ENSP00000373071|ensembl:ENSP00000389862|ensembl:ENSP00000390938|ensembl:ENSP00000393958|ensembl:ENSP00000396193|ensembl:ENSP00000408956	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx16_human(display_long)|uniprotkb:DHX16(gene name)|psi-mi:DHX16(display_short)|uniprotkb:DBP2(gene name synonym)|uniprotkb:DDX16(gene name synonym)|uniprotkb:KIAA0577(gene name synonym)|uniprotkb:DEAH-box protein 16(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #3(gene name synonym)|uniprotkb:PRP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001157711.1|refseq:NP_003578.2|ensembl:ENSG00000204560(gene)|ensembl:ENSG00000206486(gene)|ensembl:ENSG00000226171(gene)|ensembl:ENSG00000231377(gene)|ensembl:ENSG00000233049(gene)|ensembl:ENSG00000233418(gene)|ensembl:ENSG00000233561(gene)|ensembl:ENST00000376442(transcript)|ensembl:ENST00000383577(transcript)|ensembl:ENST00000417308(transcript)|ensembl:ENST00000421095(transcript)|ensembl:ENST00000424672(transcript)|ensembl:ENST00000451456(transcript)|ensembl:ENST00000458094(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF7|rcsb pdb:7DVQ|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sYCQp3qc9+wukR7aCf2qen2dgdU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NVI7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IZKJEVLLS/DFINgBgO5frizN1P49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17987	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10768	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052334|uniprotkb:Q5TBU8|uniprotkb:Q5TBV0|uniprotkb:Q5TBV2|uniprotkb:Q9BVJ2|ensembl:ENSP00000367992	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:estd_human(display_long)|uniprotkb:Esterase D(gene name synonym)|uniprotkb:ESD(gene name)|psi-mi:ESD(display_short)|uniprotkb:Methylumbelliferyl-acetate deacetylase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001975.1|refseq:XP_011533256.1|refseq:XP_005266335.1|ensembl:ENSG00000139684(gene)|ensembl:ENST00000378720(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0018738"(S-formylglutathione hydrolase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0046294"(formaldehyde catabolic process)|go:"GO:0047374"(methylumbelliferyl-acetate deacetylase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000801(Putative esterase)|interpro:IPR014186(S-formylglutathione hydrolase)|interpro:IPR029058|rcsb pdb:3FCX|reactome:R-HSA-156590	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I8V/PLKeeDbsSgkLk0BADWVbDdg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17844	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8NI36	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2512413|ensembl:ENSP00000423067|ensembl:ENSP00000479950|uniprotkb:A2RUS4|uniprotkb:Q8N1Q2|uniprotkb:Q68E02	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:wdr36_human(display_long)|uniprotkb:WDR36(gene name)|psi-mi:WDR36(display_short)|uniprotkb:T-cell activation WD repeat-containing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134987(gene)|ensembl:ENST00000506538(transcript)|ensembl:ENST00000612402(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007601"(visual perception)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|go:"GO:0050896"(response to stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR007319(Small-subunit processome, Utp21)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|refseq:NP_644810.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:97Qc0ehUPTjCBcn3gjr0FY8Nnus9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00459	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01085	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2820828|uniprotkb:A8K3T0|uniprotkb:A8K4L9|ensembl:ENSP00000394902	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tiar_human(display_long)|uniprotkb:TIAL1(gene name)|psi-mi:TIAL1(display_short)|uniprotkb:TIA-1-related protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001029097.1|refseq:NP_003243.1|ensembl:ENSG00000151923(gene)|ensembl:ENST00000436547(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007281"(germ cell development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017145"(stem cell division)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034492|interpro:IPR034494|interpro:IPR034496|interpro:IPR035979|mint:Q01085|rcsb pdb:1X4G|rcsb pdb:2CQI|rcsb pdb:2DH7|reactome:R-HSA-6803529|dip:DIP-42425N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dKWzIWmR/JaCJwsOLUPG2Z1uhH89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43487	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1032909|uniprotkb:Q53EY3|ensembl:ENSP00000327583	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rang_human(display_long)|uniprotkb:RANBP1(gene name)|psi-mi:RANBP1(display_short)|uniprotkb:Ran-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002873.1|ensembl:ENSG00000099901(gene)|ensembl:ENST00000331821(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0046907"(intracellular transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1K5D|rcsb pdb:1K5G|reactome:R-HSA-165054|refseq:NP_001265568.1|refseq:NP_001265569.1|dip:DIP-35058N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OWndphaUCDSO3+MGhJqcuQo2Lk09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62316	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297993|uniprotkb:P43330|ensembl:ENSP00000342374|ensembl:ENSP00000465216|uniprotkb:A8K797|uniprotkb:J3KPM5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd2_human(display_long)|uniprotkb:SNRPD2(gene name)|psi-mi:SNRPD2(display_short)|uniprotkb:snRNP core protein D2(gene name synonym)|uniprotkb:SNRPD1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000125743(gene)|ensembl:ENST00000342669(transcript)|ensembl:ENST00000588301(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027248|mint:P62316|rcsb pdb:1B34|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5XJL|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_004588.1|refseq:NP_808210.2|dip:DIP-31219N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4OshNPT6N4dOcWMVXrF5Fm8dcnI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40227	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356687|uniprotkb:Q3KP28|uniprotkb:Q75LP4|uniprotkb:Q96S46|ensembl:ENSP00000275603|intact:EBI-5912031|uniprotkb:A6NCD2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpz_human(display_long)|uniprotkb:CCT6A(gene name)|psi-mi:CCT6A(display_short)|uniprotkb:CCT6(gene name synonym)|uniprotkb:CCTZ(gene name synonym)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Tcp20(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Acute morphine dependence-related protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001753.1|ensembl:ENSG00000146731(gene)|ensembl:ENST00000275603(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P40227|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|refseq:NP_001009186.1|dip:DIP-33558N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kX6/rTGZbGuVLNgBW6IxdNlU46U9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22061	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353343|uniprotkb:Q14661|uniprotkb:Q16556|uniprotkb:Q5VYC1|uniprotkb:Q5VYC2|uniprotkb:Q93061|uniprotkb:Q96II9|uniprotkb:Q99625|uniprotkb:Q9BQV7|uniprotkb:Q9BQV8|uniprotkb:Q9NP03|uniprotkb:A8K109|intact:EBI-2551555|uniprotkb:J3KP72|ensembl:ENSP00000356348|ensembl:ENSP00000420813	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pimt_human(display_long)|uniprotkb:PCMT1(gene name)|psi-mi:PCMT1(display_short)|uniprotkb:Protein-beta-aspartate methyltransferase(gene name synonym)|uniprotkb:Protein L-isoaspartyl/D-aspartyl methyltransferase(gene name synonym)|uniprotkb:L-isoaspartyl protein carboxyl methyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001238978.1|refseq:NP_001238982.1|ensembl:ENSG00000120265(gene)|ensembl:ENST00000367378(transcript)|ensembl:ENST00000464889(transcript)|go:"GO:0004719"("protein-L-isoaspartate (D-aspartate) O-methyltransferase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0030091"(protein repair)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000682("Protein-L-isoaspartate(D-aspartate) O-methyltransferase")|interpro:IPR029063|mint:P22061|rcsb pdb:1I1N|rcsb pdb:1KR5|reactome:R-HSA-5676934|refseq:NP_005380.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wfsjVloc3sqDMXlvFAXQI6Fjilw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-923010|uniprotkb:Q9UGU3|intact:EBI-1056800|uniprotkb:Q20WK5|ensembl:ENSP00000216129	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ttl12_human(display_long)|uniprotkb:TTLL12(gene name)|psi-mi:TTLL12(display_short)|uniprotkb:KIAA0153(gene name synonym)|uniprotkb:Inactive tubulin--tyrosine ligase-like protein 12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055955.1|ensembl:ENSG00000100304(gene)|ensembl:ENST00000216129(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015631"(tubulin binding)|go:"GO:0030496"(midbody)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0045087"(innate immune response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:1990889"(H4K20me3 modified histone binding)|interpro:IPR004344(Tubulin-tyrosine ligase)|interpro:IPR027749|reactome:R-HSA-8955332	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MXpuEK/k1S+fNxRGLpFGTO2YH2g9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5J1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-592816|uniprotkb:Q9H4N6|ensembl:ENSP00000225298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:utp18_human(display_long)|uniprotkb:WD repeat-containing protein 50(gene name synonym)|uniprotkb:UTP18(gene name)|psi-mi:UTP18(display_short)|uniprotkb:CGI-48(orf name)|uniprotkb:CDABP0061(orf name)|uniprotkb:WDR50(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057085.2|ensembl:ENSG00000011260(gene)|ensembl:ENST00000225298(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q9Y5J1|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l873IUyfCql4N9VelHPuUEqpzRY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13148	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49368	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08670	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BSD7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2689235|ensembl:ENSP00000355587	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ntpcr_human(display_long)|uniprotkb:Nucleoside triphosphate phosphohydrolase(gene name synonym)|uniprotkb:NTPCR(gene name)|psi-mi:NTPCR(display_short)|uniprotkb:C1orf57(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_115700.1|interpro:IPR027417|mint:Q9BSD7|rcsb pdb:2I3B|ensembl:ENSG00000135778(gene)|ensembl:ENST00000366628(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004948(Protein of unknown function DUF265)|refseq:NP_001316382.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tJoP+XQzoa4urq6g1rdZhMWO49g9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96HS1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B0JYQ0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b0jyq0_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005615"(extracellular space)|go:"GO:0046872"(metal ion binding)|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZRiIE/g0lqxM4BoYZ1F4bLVNdos9913	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50897	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13283	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51532	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302489|uniprotkb:O95052|uniprotkb:Q9HBD3|uniprotkb:B1A8Z4|uniprotkb:B1A8Z5|uniprotkb:B1A8Z6|uniprotkb:B1A8Z7|uniprotkb:E9PBR8|ensembl:ENSP00000343896|ensembl:ENSP00000395654	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smca4_human(display_long)|uniprotkb:SMARCA4(gene name)|psi-mi:SMARCA4(display_short)|uniprotkb:BRG1(gene name synonym)|uniprotkb:SNF2B(gene name synonym)|uniprotkb:SNF2L4(gene name synonym)|uniprotkb:ATP-dependent helicase SMARCA4(gene name synonym)|uniprotkb:SNF2-beta(gene name synonym)|uniprotkb:BAF190A(gene name synonym)|uniprotkb:Mitotic growth and transcription activator(gene name synonym)|uniprotkb:Protein BRG-1(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4(gene name synonym)|uniprotkb:Protein brahma homolog 1(gene name synonym)|uniprotkb:BRG1-associated factor 190A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001122316.1|refseq:NP_003063.2|refseq:NP_001122317.1|refseq:NP_001122318.1|refseq:NP_001122319.1|refseq:NP_001122320.1|dip:DIP-24249N|refseq:XP_016882654.1|refseq:XP_016882655.1|refseq:XP_016882656.1|refseq:XP_016882657.1|ensembl:ENSG00000127616(gene)|ensembl:ENST00000344626(transcript)|ensembl:ENST00000429416(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0002039"(p53 binding)|go:"GO:0003407"(neural retina development)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030100|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51532|rcsb pdb:2GRC|rcsb pdb:2H60|rcsb pdb:3UVD|rcsb pdb:5DKD|rcsb pdb:5EA1|rcsb pdb:6BGH|rcsb pdb:6HR2|rcsb pdb:6LTH|rcsb pdb:6LTJ|rcsb pdb:6SY2|rcsb pdb:6ZS2|reactome:R-HSA-1266695|reactome:R-HSA-201722|reactome:R-HSA-3214858|reactome:R-HSA-3247509|reactome:R-HSA-8939243|reactome:R-HSA-9619665	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ztr+2IXfAxueSUaNYG2A47HoMes9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50990	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356507|uniprotkb:A6NN54|uniprotkb:Q4VBP8|uniprotkb:B4DEM7|uniprotkb:B4DQH4|ensembl:ENSP00000286788	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpq_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:CCTQ(gene name synonym)|uniprotkb:KIAA0002(gene name synonym)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-15(gene name synonym)|uniprotkb:C21orf112(gene name synonym)|uniprotkb:Chaperonin containing T-complex polypeptide 1 subunit 8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001269836.1|refseq:NP_001269838.1|refseq:NP_006576.2|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50990|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|ensembl:ENSG00000156261(gene)|ensembl:ENST00000286788(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016887"(ATP hydrolysis activity)|reactome:R-HSA-6798695|reactome:R-HSA-6814122|reactome:R-HSA-5620922|dip:DIP-38124N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/TlB7Gk2Z9GPvfV3JBE0nWUF34Y9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53992	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-81134|uniprotkb:Q8WV25|ensembl:ENSP00000321845|ensembl:ENSP00000343405|uniprotkb:B4DZT4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc24c_human(display_long)|uniprotkb:SEC24C(gene name)|psi-mi:SEC24C(display_short)|uniprotkb:KIAA0079(gene name synonym)|uniprotkb:SEC24-related protein C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR041742|mint:P53992|rcsb pdb:3EH2|rcsb pdb:6PU1|reactome:R-HSA-1655829|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-983170|reactome:R-HSA-5694530|ensembl:ENSG00000176986(gene)|ensembl:ENST00000339365(transcript)|ensembl:ENST00000345254(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030127"(COPII vesicle coat)|refseq:NP_004913.2|refseq:NP_940999.1|dip:DIP-30981N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kOKJkIWFOlIpRFLj5JshAGqAg6s9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P68371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351356|uniprotkb:P05217|uniprotkb:A2BFA2|ensembl:ENSP00000341289	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb4b_human(display_long)|uniprotkb:TUBB4B(gene name)|psi-mi:TUBB4B(display_short)|uniprotkb:TUBB2C(gene name synonym)|uniprotkb:Tubulin beta-2 chain(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006079.1|ensembl:ENSG00000188229(gene)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|go:"GO:0005200"(structural constituent of cytoskeleton)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68371|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|ensembl:ENST00000340384(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4LwMs7E7eILMjB9Z/1bstAp22CY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BV40	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727028|uniprotkb:O60625|uniprotkb:Q53SP9|uniprotkb:Q6IB09|ensembl:ENSP00000263864	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vamp8_human(display_long)|uniprotkb:Endobrevin(gene name synonym)|uniprotkb:VAMP8(gene name)|psi-mi:VAMP8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003752.2|ensembl:ENSG00000118640(gene)|ensembl:ENST00000263864(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|mint:Q9BV40|rcsb pdb:4WY4|rcsb pdb:7BV6|reactome:R-HSA-1236974|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|dip:DIP-40358N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DW/t33n6NkBelQt6H1QS5hUY5+E9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99832	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7RTV0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2555365|uniprotkb:Q9UH06|ensembl:ENSP00000216252	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phf5a_human(display_long)|uniprotkb:Splicing factor 3B-associated 14 kDa protein(gene name synonym)|uniprotkb:PHF5A(gene name)|psi-mi:PHF5A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_116147.1|ensembl:ENSG00000100410(gene)|ensembl:ENST00000216252(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR005345(PHF5-like)|mint:Q7RTV0|rcsb pdb:5IFE|rcsb pdb:5O9Z|rcsb pdb:5SYB|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:5ZYA|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|go:"GO:0048863"(stem cell differentiation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TrngLk+KyJ+qRs8HGvH1LZH2Tsg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07737	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713780|ensembl:ENSP00000225655|uniprotkb:Q53Y44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prof1_human(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:PFN1(gene name)|psi-mi:PFN1(display_short)|uniprotkb:Epididymis tissue protein Li 184a(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108518(gene)|ensembl:ENST00000225655(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P07737|rcsb pdb:1AWI|rcsb pdb:1CF0|rcsb pdb:1CJF|rcsb pdb:1FIK|rcsb pdb:1FIL|rcsb pdb:1PFL|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|rcsb pdb:4X1L|rcsb pdb:4X1M|rcsb pdb:4X25|rcsb pdb:6NAS|rcsb pdb:6NBE|rcsb pdb:6NBW|reactome:R-HSA-114608|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|reactome:R-HSA-4086400|reactome:R-HSA-5663220|reactome:R-HSA-376176|refseq:NP_005013.1|dip:DIP-30N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CncaC5RMylvzFLhqzpS+VbhQn6I9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P20618	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372273|uniprotkb:Q9BWA8|ensembl:ENSP00000262193|uniprotkb:B5BU76	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb1_human(display_long)|uniprotkb:PSMB1(gene name)|psi-mi:PSMB1(display_short)|uniprotkb:PSC5(gene name synonym)|uniprotkb:Proteasome component C5(gene name synonym)|uniprotkb:Macropain subunit C5(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C5(gene name synonym)|uniprotkb:Proteasome gamma chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000008018(gene)|ensembl:ENST00000262193(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035202|mint:P20618|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5L5B|rcsb pdb:5L5D|rcsb pdb:5L5E|rcsb pdb:5L5F|refseq:NP_002784.1|rcsb pdb:5L5H|rcsb pdb:5L5I|rcsb pdb:5L5J|rcsb pdb:5L5O|rcsb pdb:5L5P|rcsb pdb:5L5Q|rcsb pdb:5L5R|rcsb pdb:5L5S|rcsb pdb:5L5T|rcsb pdb:5L5U|rcsb pdb:5L5V|rcsb pdb:5L5W|rcsb pdb:5L5X|rcsb pdb:5L5Y|rcsb pdb:5L5Z|rcsb pdb:5L60|rcsb pdb:5L61|rcsb pdb:5L62|rcsb pdb:5L63|rcsb pdb:5L64|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M2B|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5LF1|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4608870|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-983168|reactome:R-HSA-9604323|dip:DIP-31193N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DfIS480BUnqbXus9/KoojdkWgw09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49458	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350743|uniprotkb:Q6NVX0|uniprotkb:Q8WTW0|ensembl:ENSP00000305230|uniprotkb:A8K0N0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srp09_human(display_long)|uniprotkb:SRP9(gene name)|psi-mi:SRP9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4UYJ|refseq:NP_001123912.1|refseq:NP_003124.1|ensembl:ENSG00000143742(gene)|ensembl:ENST00000304786(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005785"(signal recognition particle receptor complex)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0045900"(negative regulation of translational elongation)|interpro:IPR008832(Signal recognition particle, SRP9 subunit)|interpro:IPR009018(Signal recognition particle, SRP9/SRP14 subunit)|interpro:IPR039432|interpro:IPR039914|mint:P49458|rcsb pdb:1E8O|rcsb pdb:1E8S|rcsb pdb:1RY1|rcsb pdb:4UYK|rcsb pdb:5AOX|rcsb pdb:7NFX|reactome:R-HSA-1799339|dip:DIP-6151N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y33fEeeXnma9oF7Fzs6zEGQjVBU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00403	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-389564|uniprotkb:A8K1A7|uniprotkb:Q5JS30|ensembl:ENSP00000359531	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tf2b_human(display_long)|uniprotkb:GTF2B(gene name)|psi-mi:GTF2B(display_short)|uniprotkb:TF2B(gene name synonym)|uniprotkb:TFIIB(gene name synonym)|uniprotkb:General transcription factor TFIIB(gene name synonym)|uniprotkb:S300-II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001505.1|ensembl:ENSG00000137947(gene)|ensembl:ENST00000370500(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001174"(transcriptional start site selection at RNA polymerase II promoter)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005694"(chromosome)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019083"(viral transcription)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990114"(RNA polymerase II core complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000812(Transcription factor TFIIB related)|interpro:IPR013137(Zinc finger, TFIIB-type)|interpro:IPR013150(Transcription factor TFIIB, cyclin-related)|interpro:IPR013763(Cyclin-related)|interpro:IPR023486|interpro:IPR036915|mint:Q00403|rcsb pdb:1C9B|rcsb pdb:1DL6|rcsb pdb:1RLY|rcsb pdb:1RO4|rcsb pdb:1TFB|rcsb pdb:1VOL|rcsb pdb:2PHG|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5WH1|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|dip:DIP-1077N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mVGHi0jBibSFHpBrVTGHnRm4gXw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9GZT3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WUM4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-310624|uniprotkb:Q9BX86|uniprotkb:Q9NUN0|uniprotkb:Q9P2H2|uniprotkb:Q9UKL5|uniprotkb:C5MQH7|intact:EBI-10971645|uniprotkb:E9PFU1|uniprotkb:Q6NUS1|ensembl:ENSP00000307387|intact:EBI-28983290	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdc6i_human(display_long)|uniprotkb:PDCD6IP(gene name)|psi-mi:PDCD6IP(display_short)|uniprotkb:AIP1(gene name synonym)|uniprotkb:KIAA1375(gene name synonym)|uniprotkb:ALIX(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:Hp95(gene name synonym)|uniprotkb:ALG-2-interacting protein X(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_037506.2|ensembl:ENSP00000307387|ensembl:ENST00000457054|ensembl:ENSP00000411825|refseq:NP_001155901.1|ensembl:ENSG00000170248(gene)|ensembl:ENST00000307296(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q8WUM4|rcsb pdb:2OEV|rcsb pdb:2OEW|rcsb pdb:2OEX|rcsb pdb:2OJQ|rcsb pdb:2R02|rcsb pdb:2R03|rcsb pdb:2R05|rcsb pdb:2XS1|rcsb pdb:2XS8|rcsb pdb:2ZNE|rcsb pdb:3C3O|rcsb pdb:3C3Q|rcsb pdb:3C3R|rcsb pdb:3E1R|rcsb pdb:3WUV|rcsb pdb:4JJY|rcsb pdb:5V3R|rcsb pdb:5WA1|rcsb pdb:6KP3|reactome:R-HSA-162588|reactome:R-HSA-5210891|reactome:R-HSA-5213460|reactome:R-HSA-5675482|refseq:NP_001243121.1|dip:DIP-29327N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FYD19EyMBAGl204Xlgr4MlE8GMs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P98179	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2949699|ensembl:ENSP00000365946|ensembl:ENSP00000365950	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm3_human(display_long)|uniprotkb:RBM3(gene name)|psi-mi:RBM3(display_short)|uniprotkb:RNPL(gene name synonym)|uniprotkb:RNA-binding motif protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030425"(dendrite)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:P98179|go:"GO:0006417"(regulation of translation)|ensembl:ENSG00000102317(gene)|ensembl:ENST00000376755(transcript)|ensembl:ENST00000376759(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|refseq:NP_006734.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+KPnDlgXy+KGVDjTilKMXb5dJGs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7KZF4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044112|uniprotkb:Q13122|ensembl:ENSP00000346762|uniprotkb:Q96AG0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snd1_human(display_long)|uniprotkb:100 kDa coactivator(gene name synonym)|uniprotkb:EBNA2 coactivator p100(gene name synonym)|uniprotkb:Tudor domain-containing protein 11(gene name synonym)|uniprotkb:SND1(gene name)|psi-mi:SND1(display_short)|uniprotkb:p100 co-activator(gene name synonym)|uniprotkb:TDRD11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055205.2|ensembl:ENSG00000197157(gene)|ensembl:ENST00000354725(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0042470"(melanosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097433"(dense body)|go:"GO:1905172"(RISC complex binding)|interpro:IPR002071(Thermonuclease active site)|interpro:IPR002999(Tudor)|interpro:IPR016071("Staphylococcal nuclease (SNase-like), OB-fold")|interpro:IPR016685(RNA-induced silencing complex, nuclease component Tudor-SN)|interpro:IPR035437|mint:Q7KZF4|rcsb pdb:2E6N|rcsb pdb:2HQE|rcsb pdb:2HQX|rcsb pdb:2O4X|rcsb pdb:3BDL|rcsb pdb:3OMC|rcsb pdb:3OMG|rcsb pdb:4QMG|rcsb pdb:5M9O|reactome:R-HSA-6802952|dip:DIP-29613N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I9JNlRfASs5dwk0JZQ+F+GsW94g9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P16949	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-445909|uniprotkb:A2A2D1|uniprotkb:B7Z8N4|uniprotkb:D3DPJ5|uniprotkb:B2R4E7|ensembl:ENSP00000350531|ensembl:ENSP00000363409|ensembl:ENSP00000382633|ensembl:ENSP00000387858	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stmn1_human(display_long)|uniprotkb:Phosphoprotein p19(gene name synonym)|uniprotkb:Leukemia-associated phosphoprotein p18(gene name synonym)|uniprotkb:Oncoprotein 18(gene name synonym)|uniprotkb:pp17(gene name synonym)|uniprotkb:Prosolin(gene name synonym)|uniprotkb:Metablastin(gene name synonym)|uniprotkb:Protein Pr22(gene name synonym)|uniprotkb:STMN1(gene name)|psi-mi:STMN1(display_short)|uniprotkb:LAP18(gene name synonym)|uniprotkb:OP18(gene name synonym)|uniprotkb:C1orf215(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138926.1|refseq:NP_005554.1|refseq:NP_981944.1|refseq:NP_981946.1|ensembl:ENST00000357865(transcript)|ensembl:ENST00000374291(transcript)|ensembl:ENST00000399728(transcript)|ensembl:ENST00000455785(transcript)|go:"GO:0000281"(mitotic cytokinesis)|ensembl:ENSG00000117632(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|mint:P16949|interpro:IPR000956(Stathmin)|interpro:IPR030514|interpro:IPR036002|reactome:R-HSA-1251985	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gew+NqUuLLolCLCXOyXIZkRieIs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62913	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354380|uniprotkb:P25121|uniprotkb:P39026|uniprotkb:Q8TDH2|uniprotkb:Q9Y674|ensembl:ENSP00000496250	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl11_human(display_long)|uniprotkb:RPL11(gene name)|psi-mi:RPL11(display_short)|uniprotkb:CLL-associated antigen KW-12(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000966.2|refseq:NP_001186731.1|ensembl:ENSG00000142676(gene)|ensembl:ENST00000643754(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006605"(protein targeting)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR002132(Ribosomal protein L5)|interpro:IPR020929|interpro:IPR022803|interpro:IPR031309|interpro:IPR031310|mint:P62913|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4XXB|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y6X	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xt8XhDkfQPoH4DIPr0gC+ll766Q9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P37802	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056740|intact:EBI-2825986|uniprotkb:Q5JRQ6|uniprotkb:Q5JRQ7|uniprotkb:Q9BUH5|uniprotkb:Q9H4P0|uniprotkb:Q6FGI1|uniprotkb:E9KL39|ensembl:ENSP00000357075|ensembl:ENSP00000357077	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tagl2_human(display_long)|uniprotkb:TAGLN2(gene name)|psi-mi:TAGLN2(display_short)|uniprotkb:KIAA0120(gene name synonym)|uniprotkb:SM22-alpha homolog(gene name synonym)|uniprotkb:CDABP0035(orf name)|uniprotkb:Epididymis tissue protein Li 7e(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003555.1|refseq:NP_001264152.1|refseq:NP_001264153.1|ensembl:ENSG00000158710(gene)|ensembl:ENST00000320307(transcript)|ensembl:ENST00000368097(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000557(Calponin repeat)|interpro:IPR001061("Transgelin (SM22-alpha)")|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|mint:P37802|rcsb pdb:1WYM|reactome:R-HSA-114608	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxbMK5SbZWQd+XA9iYc/xuNaVQc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62306	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356900|uniprotkb:A2VCR2|uniprotkb:Q15356|uniprotkb:Q6IBQ1|uniprotkb:Q6P4I0|uniprotkb:B2R498|ensembl:ENSP00000266735	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ruxf_human(display_long)|uniprotkb:SNRPF(gene name)|psi-mi:SNRPF(display_short)|uniprotkb:PBSCF(gene name synonym)|uniprotkb:Sm protein F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003086.1|ensembl:ENSG00000139343(gene)|ensembl:ENST00000266735(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|dip:DIP-31221N|rcsb pdb:5XJL|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6V4X|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-111367|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-73856|reactome:R-HSA-77588|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|interpro:IPR034100|mint:P62306|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2RggXu+kFj6wG7gTmxRHOIRvXiM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61313	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-443462|ensembl:ENSP00000309334|ensembl:ENSP00000346867|ensembl:ENSP00000388529|ensembl:ENSP00000416692|ensembl:ENSP00000483260|ensembl:ENSP00000493759|uniprotkb:Q642I1|uniprotkb:Q9H2E5|uniprotkb:P39030|uniprotkb:P41051|uniprotkb:Q6IPX6|uniprotkb:Q8WYP2|uniprotkb:Q96C44|uniprotkb:Q5U0C0|intact:EBI-2877712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl15_human(display_long)|uniprotkb:RPL15(gene name)|psi-mi:RPL15(display_short)|uniprotkb:EC45(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL15(gene name synonym)|uniprotkb:TCBAP0781(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000174748(gene)|ensembl:ENST00000307839(transcript)|ensembl:ENST00000354811(transcript)|ensembl:ENST00000413699(transcript)|ensembl:ENST00000415719(transcript)|ensembl:ENST00000611050(transcript)|ensembl:ENST00000644185(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|interpro:IPR000439(Ribosomal protein L15e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR020925|interpro:IPR024794|mint:P61313|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_002939.2|refseq:NP_001240308.1|refseq:NP_001240309.1|refseq:NP_001240311.1|refseq:NP_001240312.1|refseq:NP_001240313.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wllGpJicgC5uwkZV6e4QRwDcrBo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6190532	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	-	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c9j6d7_human(display_short)|psi-mi:EBI-6190532(display_long)|uniprotkb:KIAA0664(gene name)|psi-mi:KIAA0664(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	uniprotkb:C9J6D7(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vIKw9yo22CTfO4A1eK7NsIpcGkI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54577	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048893|uniprotkb:O43276|uniprotkb:Q53EN1|uniprotkb:B3KWK4|uniprotkb:D3DPQ4|ensembl:ENSP00000362576	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syyc_human(display_long)|uniprotkb:YARS1(gene name)|psi-mi:YARS1(display_short)|uniprotkb:Tyrosyl-tRNA synthetase(gene name synonym)|uniprotkb:YARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003671.1|ensembl:ENSG00000134684(gene)|ensembl:ENST00000373477(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004831"(tyrosine-tRNA ligase activity)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006437"(tyrosyl-tRNA aminoacylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0016604"(nuclear body)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002307(Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial)|interpro:IPR002547(tRNA-binding region)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1N3L|rcsb pdb:1NTG|rcsb pdb:1Q11|rcsb pdb:4Q93|rcsb pdb:4QBT|rcsb pdb:5THH|rcsb pdb:5THL|reactome:R-HSA-379716|dip:DIP-50415N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y/0Qs8iOgW5w5LVLWnCvowVpEu89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99623	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:h4pib54mBeQgOKCe/hib58LM26w9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26640	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355765|uniprotkb:Q5JQ90|uniprotkb:Q96E77|uniprotkb:Q9UQM2|uniprotkb:B4DZ61|uniprotkb:B0V1N1|ensembl:ENSP00000211402|ensembl:ENSP00000364815|ensembl:ENSP00000401121|ensembl:ENSP00000403359|ensembl:ENSP00000415316	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syvc_human(display_long)|uniprotkb:VARS1(gene name)|psi-mi:VARS1(display_short)|uniprotkb:G7A(gene name synonym)|uniprotkb:Protein G7a(gene name synonym)|uniprotkb:VARS(gene name synonym)|uniprotkb:VARS2(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006286.1|ensembl:ENSG00000096171(gene)|ensembl:ENSG00000204394(gene)|ensembl:ENSG00000224264(gene)|ensembl:ENSG00000226589(gene)|ensembl:ENSG00000231116(gene)|ensembl:ENST00000211402(transcript)|ensembl:ENST00000375663(transcript)|ensembl:ENST00000422694(transcript)|ensembl:ENST00000435657(transcript)|ensembl:ENST00000457796(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|interpro:IPR036282|interpro:IPR037118|mint:P26640|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aPfpK0/C2KpCsMOI0sjCreufI509606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P37108	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353399|uniprotkb:Q6B0K5|intact:EBI-1053250|uniprotkb:Q96Q14|uniprotkb:B5BUF5|ensembl:ENSP00000267884	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srp14_human(display_long)|uniprotkb:SRP14(gene name)|psi-mi:SRP14(display_short)|uniprotkb:18 kDa Alu RNA-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003125.3|dip:DIP-6152N|ensembl:ENSG00000140319(gene)|ensembl:ENST00000267884(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045047"(protein targeting to ER)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003210(Signal recognition particle, SRP14 subunit)|interpro:IPR009018(Signal recognition particle, SRP9/SRP14 subunit)|mint:P37108|rcsb pdb:1E8O|rcsb pdb:1E8S|rcsb pdb:1RY1|rcsb pdb:4UYJ|rcsb pdb:4UYK|rcsb pdb:5AOX|rcsb pdb:7NFX|reactome:R-HSA-1799339|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0xHelIgJbXaUrFsHGoj1wDQKdPs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BQ69	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5324932|ensembl:ENSP00000255681|uniprotkb:Q9UH96	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:macd1_human(display_long)|uniprotkb:MACROD1(gene name)|psi-mi:MACROD1(display_short)|uniprotkb:LRP16(gene name synonym)|uniprotkb:Protein LRP16(gene name synonym)|uniprotkb:MACRO domain-containing protein 1(gene name synonym)|uniprotkb:O-acetyl-ADP-ribose deacetylase MACROD1(gene name synonym)|uniprotkb:[Protein ADP-ribosylaspartate] hydrolase MACROD1(gene name synonym)|uniprotkb:[Protein ADP-ribosylglutamate] hydrolase MACROD1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000133315(gene)|ensembl:ENST00000255681(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0019213"(deacetylase activity)|go:"GO:0042278"(purine nucleoside metabolic process)|go:"GO:0051725"(protein de-ADP-ribosylation)|go:"GO:0140291"(peptidyl-glutamate ADP-deribosylation)|go:"GO:0140293"(ADP-ribosylglutamate hydrolase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR043472|rcsb pdb:2X47|rcsb pdb:6LH4|refseq:NP_054786.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7gwLLBJKnqqdb89NYKEAtOdmMdU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00059	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13242	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2949710|ensembl:ENSP00000229390|uniprotkb:Q52LD1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf9_human(display_long)|uniprotkb:SRSF9(gene name)|psi-mi:SRSF9(display_short)|uniprotkb:SFRS9(gene name synonym)|uniprotkb:SRP30C(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30C(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006397"(mRNA processing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0006376"(mRNA splice site selection)|interpro:IPR034503|interpro:IPR034995|interpro:IPR035979|mint:Q13242|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|ensembl:ENSG00000111786(gene)|ensembl:ENST00000229390(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_003760.1|dip:DIP-40741N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9x6TWFk1zN1YodjXBiwi/MtNJe49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62937	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32322	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NSD9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353803|uniprotkb:B4DFM0|uniprotkb:O95708|uniprotkb:Q9NZZ6|uniprotkb:Q4ZFX1|uniprotkb:Q57ZJ5|ensembl:ENSP00000281828	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syfb_human(display_long)|uniprotkb:FARSB(gene name)|psi-mi:FARSB(display_short)|uniprotkb:FARSLB(gene name synonym)|uniprotkb:FRSB(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase beta subunit(gene name synonym)|uniprotkb:HSPC173(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005678.3|refseq:XP_006712232.1|refseq:XP_011508768.1|ensembl:ENSG00000116120(gene)|ensembl:ENST00000281828(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR004531(Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR005147(tRNA synthetase, B5)|interpro:IPR009061(Putative DNA binding)|interpro:IPR020825|interpro:IPR040659|interpro:IPR041616|rcsb pdb:3L4G|reactome:R-HSA-379716|refseq:XP_016858599.1|dip:DIP-32869N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YgMUMEiw+jAUaDK5KomMWi66vn09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O76021	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358028|uniprotkb:Q2M1T7|uniprotkb:Q6PL22|uniprotkb:Q8IWS7|uniprotkb:Q8WUZ1|uniprotkb:Q9HDA9|uniprotkb:Q9Y3Z9|uniprotkb:B4DJ58|uniprotkb:D3DUG7|ensembl:ENSP00000460871	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl1d1_human(display_long)|uniprotkb:RSL1D1(gene name)|psi-mi:RSL1D1(display_short)|uniprotkb:CSIG(gene name synonym)|uniprotkb:PBK1(gene name synonym)|uniprotkb:CATX11(gene name synonym)|uniprotkb:L12(orf name)|uniprotkb:Cellular senescence-inhibited gene protein(gene name synonym)|uniprotkb:Protein PBK1(gene name synonym)|uniprotkb:CATX-11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056474.2|ensembl:ENSG00000171490(gene)|ensembl:ENST00000571133(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030686"(90S preribosome)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023674|interpro:IPR028364|mint:O76021	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/mAkpodrvvZA6mz3M8VwHDEJzKo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62314	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372177|uniprotkb:P13641|uniprotkb:B5BTZ1|ensembl:ENSP00000300413	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd1_human(display_long)|uniprotkb:SNRPD1(gene name)|psi-mi:SNRPD1(display_short)|uniprotkb:snRNP core protein D1(gene name synonym)|uniprotkb:Sm-D autoantigen(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001278845.1|refseq:NP_008869.1|ensembl:ENSG00000167088(gene)|ensembl:ENST00000300413(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|go:"GO:0000243"(commitment complex)|interpro:IPR027141|interpro:IPR034102|mint:P62314|rcsb pdb:1B34|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|go:"GO:0000245"(spliceosomal complex assembly)|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5XJL|rcsb pdb:5XJQ|go:"GO:0000387"(spliceosomal snRNP assembly)|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|dip:DIP-31207N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfXwsV+IOjDPCoOJOoMQgECyiII9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22087	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358318|uniprotkb:O75259|uniprotkb:Q6IAT5|uniprotkb:Q9UPI6|ensembl:ENSP00000221801|ensembl:ENSP00000487390|uniprotkb:B5BUE8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fbrl_human(display_long)|uniprotkb:FBL(gene name)|psi-mi:FBL(display_short)|uniprotkb:FIB1(gene name synonym)|uniprotkb:FLRN(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)|uniprotkb:34 kDa nucleolar scleroderma antigen(gene name synonym)|uniprotkb:U6 snRNA 2'-O-methyltransferase fibrillarin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001427.2|ensembl:ENSG00000105202(gene)|ensembl:ENSG00000280548(gene)|ensembl:ENST00000221801(transcript)|ensembl:ENST00000625241(transcript)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0001652"(granular component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|mint:P22087|rcsb pdb:2IPX|reactome:R-HSA-6790901|reactome:R-HSA-6791226|dip:DIP-27569N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8m8FDRSxGNKNXpJMcWWbcHL3uss9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07947	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H3S7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724478|uniprotkb:Q7KZF8|uniprotkb:Q8N6Z5|uniprotkb:Q9BSR5|uniprotkb:Q9P257|uniprotkb:Q9UG03|uniprotkb:Q9UMZ4|uniprotkb:A8K0D7|ensembl:ENSP00000265562	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptn23_human(display_long)|uniprotkb:His domain-containing protein tyrosine phosphatase(gene name synonym)|uniprotkb:Protein tyrosine phosphatase TD14(gene name synonym)|uniprotkb:PTPN23(gene name)|psi-mi:PTPN23(display_short)|uniprotkb:KIAA1471(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056281.1|ensembl:ENSG00000076201(gene)|ensembl:ENST00000265562(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0060271"(cilium assembly)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903387"(positive regulation of homophilic cell adhesion)|go:"GO:1903393"(positive regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004328(BRO1)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR025304|interpro:IPR029021|interpro:IPR038499|mint:Q9H3S7|rcsb pdb:5CRU|rcsb pdb:5CRV|rcsb pdb:5LM1|rcsb pdb:5LM2|rcsb pdb:5MJY|rcsb pdb:5MJZ|rcsb pdb:5MK0|rcsb pdb:5MK1|rcsb pdb:5MK2|rcsb pdb:5MK3|reactome:R-HSA-9008059|rcsb pdb:3RAU|refseq:NP_001291411.1|dip:DIP-29923N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PeqzQLL4J4v9IMuHFBlb+1B4Ujw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26599	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350540|ensembl:ENSP00000014112|intact:EBI-744534|uniprotkb:Q9BUQ0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptbp1_human(display_long)|uniprotkb:PTBP1(gene name)|psi-mi:PTBP1(display_short)|uniprotkb:PTB(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein I(gene name synonym)|uniprotkb:57 kDa RNA-binding protein PPTB-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002810.1|refseq:NP_114367.1|refseq:NP_114368.1|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0016020"(membrane)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034798|interpro:IPR035000|interpro:IPR035001|interpro:IPR035979|mint:P26599|rcsb pdb:1QM9|rcsb pdb:1SJQ|ensembl:ENSG00000011304(gene)|ensembl:ENST00000349038(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0008380"(RNA splicing)|rcsb pdb:2AD9|rcsb pdb:2ADB|rcsb pdb:2ADC|rcsb pdb:2EVZ|rcsb pdb:2N3O|rcsb pdb:3ZZY|rcsb pdb:3ZZZ|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|rcsb pdb:1SJR	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fkSnYJELgHxDP0oAQEjBmSX0HIs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13526	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40939	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473271|uniprotkb:Q2NKN2|uniprotkb:Q59EA1|ensembl:ENSP00000296702	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcrg1_human(display_long)|uniprotkb:TATA box-binding protein-associated factor 2S(gene name synonym)|uniprotkb:Transcription factor CA150(gene name synonym)|uniprotkb:TCERG1(gene name)|psi-mi:TCERG1(display_short)|uniprotkb:CA150(gene name synonym)|uniprotkb:TAF2S(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035095.1|refseq:NP_006697.2|dip:DIP-32504N|ensembl:ENSG00000113649(gene)|ensembl:ENST00000296702(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003711"(transcription elongation regulator activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0042802"(identical protein binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002713(FF)|interpro:IPR036020|interpro:IPR036517|mint:O14776|rcsb pdb:2DK7|rcsb pdb:2DOD|rcsb pdb:2DOE|rcsb pdb:2DOF|rcsb pdb:2E71|rcsb pdb:2KIQ|rcsb pdb:2KIS|rcsb pdb:2MW9|rcsb pdb:2MWA|rcsb pdb:2MWB|rcsb pdb:2MWD|rcsb pdb:2MWE|rcsb pdb:2MWF|rcsb pdb:2N4R|rcsb pdb:2N4S|rcsb pdb:2N4T|rcsb pdb:2N4U|rcsb pdb:2N4V|rcsb pdb:2N4W|rcsb pdb:2NNT|rcsb pdb:3HFH|rcsb pdb:3Q1I|rcsb pdb:4FQG|rcsb pdb:7ABF|rcsb pdb:7ABG	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KDFTOtTUWHzQ9yzRj7BbhFTQXiM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95036	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190520	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:o95036_human(display_long)|uniprotkb:"WUGSC:H_RG054D04.1"(gene name)|psi-mi:"WUGSC:H_RG054D04.1"(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR018038|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/Wx1NRwTL4OL8HlPLKeaZ568pCA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NP79	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-740160|uniprotkb:Q5TGM1|uniprotkb:Q6IAE8|uniprotkb:Q9H0R2|uniprotkb:Q9H3K9|uniprotkb:Q9P0Q0|uniprotkb:E1P594|ensembl:ENSP00000356602|uniprotkb:B4DW55|uniprotkb:E7ETQ7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vta1_human(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:HSPC228(orf name)|uniprotkb:My012(orf name)|uniprotkb:SKD1-binding protein 1(gene name synonym)|uniprotkb:C6orf55(gene name synonym)|uniprotkb:Dopamine-responsive gene 1 protein(gene name synonym)|uniprotkb:LYST-interacting protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001273300.1|refseq:NP_001273301.1|refseq:NP_057569.2|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:4U7E|reactome:R-HSA-162588|reactome:R-HSA-917729|ensembl:ENSG00000009844(gene)|ensembl:ENST00000367630(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LXL|rcsb pdb:2LXM|rcsb pdb:4TXP	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QIeYrvtJGJ2jWli8PWK9TeO6gus9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42285	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347612|uniprotkb:Q2M386|uniprotkb:Q6MZZ8|uniprotkb:Q6P170|uniprotkb:Q8N5R0|uniprotkb:Q8TAG2|ensembl:ENSP00000230640	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mtrex_human(display_long)|uniprotkb:MTREX(gene name)|psi-mi:MTREX(display_short)|uniprotkb:DOB1(gene name synonym)|uniprotkb:KIAA0052(gene name synonym)|uniprotkb:MTR4(gene name synonym)|uniprotkb:SKIV2L2(gene name synonym)|uniprotkb:Superkiller viralicidic activity 2-like 2(gene name synonym)|uniprotkb:TRAMP-like complex helicase(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DOB1(gene name synonym)|uniprotkb:ATP-dependent RNA helicase SKIV2L2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056175.3|ensembl:ENSG00000039123(gene)|ensembl:ENST00000230640(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016076"(snRNA catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0031499"(TRAMP complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|mint:P42285|rcsb pdb:6C90|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6IEG|rcsb pdb:6IEH|rcsb pdb:6RO1|reactome:R-HSA-6791226|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bQdFDddFhetSp+CJ1S7Q5cm+g0k9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32119	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1266300|uniprotkb:P31945|uniprotkb:P32118|uniprotkb:P35701|uniprotkb:Q6FHG4|uniprotkb:Q92763|uniprotkb:Q9UC23|uniprotkb:A8K0C0|ensembl:ENSP00000301522	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx2_human(display_long)|uniprotkb:PRDX2(gene name)|psi-mi:PRDX2(display_short)|uniprotkb:NKEFB(gene name synonym)|uniprotkb:TDPX1(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor B(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005800.3|dip:DIP-39882N|ensembl:ENSG00000167815(gene)|ensembl:ENST00000301522(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P32119|rcsb pdb:1QMV|rcsb pdb:5B8A|rcsb pdb:5B8B|rcsb pdb:5IJT|rcsb pdb:7KIZ|rcsb pdb:7KJ0|rcsb pdb:7KJ1|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:F8+7/3HrAcJq7BjkZaig16mCOO89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q53FZ2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190543|ensembl:ENSP00000289416|uniprotkb:O60363|uniprotkb:Q13732|uniprotkb:Q15425|uniprotkb:Q7KYM6|uniprotkb:Q9BUA2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:acsm3_human(display_long)|uniprotkb:Propionate--CoA ligase(gene name synonym)|uniprotkb:ACSM3(gene name)|psi-mi:ACSM3(display_short)|uniprotkb:SAH(gene name synonym)|uniprotkb:Acyl-CoA synthetase medium-chain family member 3(gene name synonym)|uniprotkb:Butyrate--CoA ligase 3(gene name synonym)|uniprotkb:Butyryl-coenzyme A synthetase 3(gene name synonym)|uniprotkb:Middle-chain acyl-CoA synthetase 3(gene name synonym)|uniprotkb:Protein SA homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR042099|reactome:R-HSA-77352|go:"GO:0047760"(butyrate-CoA ligase activity)|ensembl:ENSG00000005187(gene)|ensembl:ENST00000289416(transcript)|go:"GO:0004321"(fatty-acyl-CoA synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015645"(fatty acid ligase activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043759"(methylbutanoate-CoA ligase activity)|go:"GO:0046872"(metal ion binding)|refseq:NP_005613.2|refseq:NP_973729.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Do1rTLtpYet8Ez8zkBcq9SZnI8g9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15185	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92973	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286693|intact:EBI-1760498|uniprotkb:Q92957|uniprotkb:Q92975|intact:EBI-1965561|uniprotkb:B4DVC6|ensembl:ENSP00000336712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tnpo1_human(display_long)|uniprotkb:TRN(gene name synonym)|uniprotkb:TNPO1(gene name)|psi-mi:TNPO1(display_short)|uniprotkb:KPNB2(gene name synonym)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Importin beta-2(gene name synonym)|uniprotkb:Karyopherin beta-2(gene name synonym)|uniprotkb:M9 region interaction protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002261.3|refseq:NP_694858.1|refseq:XP_005248557.1|dip:DIP-29335N|ensembl:ENSG00000083312(gene)|ensembl:ENST00000337273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q92973|rcsb pdb:1QBK|rcsb pdb:2H4M|rcsb pdb:2OT8|rcsb pdb:2QMR|rcsb pdb:2Z5J|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:2Z5N|rcsb pdb:2Z5O|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:4JLQ|rcsb pdb:4OO6|rcsb pdb:5J3V|rcsb pdb:5TQC|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:7CYL|reactome:R-HSA-450513|reactome:R-HSA-5620924|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n8Q3n1rmTiJAp6f8DBcBV6j6lac9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26368	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742339|uniprotkb:Q96HC5|intact:EBI-946034|ensembl:ENSP00000307863	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u2af2_human(display_long)|uniprotkb:U2AF2(gene name)|psi-mi:U2AF2(display_short)|uniprotkb:U2AF65(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor large subunit(gene name synonym)|uniprotkb:U2 auxiliary factor 65 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|refseq:NP_001012496.1|refseq:NP_009210.1|ensembl:ENSG00000063244(gene)|ensembl:ENST00000308924(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|rcsb pdb:2HZC|rcsb pdb:2M0G|rcsb pdb:2U2F|rcsb pdb:2YH0|rcsb pdb:2YH1|rcsb pdb:3VAF|rcsb pdb:3VAG|rcsb pdb:3VAH|rcsb pdb:3VAI|rcsb pdb:3VAJ|rcsb pdb:3VAK|rcsb pdb:3VAL|rcsb pdb:3VAM|rcsb pdb:4FXW|rcsb pdb:4TU7|rcsb pdb:4TU8|rcsb pdb:4TU9|rcsb pdb:5EV1|rcsb pdb:5EV2|rcsb pdb:5EV3|rcsb pdb:5EV4|rcsb pdb:5W0G|rcsb pdb:5W0H|rcsb pdb:6TR0|rcsb pdb:6XLV|rcsb pdb:6XLW|rcsb pdb:6XLX|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:2G4B|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006529(U2 snRNP auxilliary factor, large subunit, splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P26368|rcsb pdb:1JMT|rcsb pdb:1O0P|rcsb pdb:1OPI|rcsb pdb:1U2F|go:"GO:0005654"(nucleoplasm)|dip:DIP-2154N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HBYwOej94CoGGN7vPbk0AnbO61Q9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P258	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352547|uniprotkb:Q8IVL9|uniprotkb:Q9BSN6|uniprotkb:Q9NPV8|ensembl:ENSP00000364582|ensembl:ENSP00000364585|ensembl:ENSP00000486099|ensembl:ENSP00000486447	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rcc2_human(display_long)|uniprotkb:RCC2(gene name)|psi-mi:RCC2(display_short)|uniprotkb:KIAA1470(gene name synonym)|uniprotkb:TD60(gene name synonym)|uniprotkb:Telophase disk protein of 60 kDa(gene name synonym)|uniprotkb:RCC1-like protein TD-60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129676.1|refseq:NP_061185.1|ensembl:ENSG00000179051(gene)|ensembl:ENSG00000281540(gene)|ensembl:ENST00000375433(transcript)|ensembl:ENST00000375436(transcript)|ensembl:ENST00000628984(transcript)|ensembl:ENST00000631021(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR028641|mint:Q9P258|rcsb pdb:5GWN|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:z9+0avftBLs4Q3ODFHLEmJtd57A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3C6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2557649|uniprotkb:Q5TDC9|uniprotkb:O15001|ensembl:ENSP00000362803	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppil1_human(display_long)|uniprotkb:PPIL1(gene name)|psi-mi:PPIL1(display_short)|uniprotkb:Rotamase PPIL1(gene name synonym)|uniprotkb:CYPL1(gene name synonym)|uniprotkb:CGI-124(orf name)|uniprotkb:UNQ2425/PRO4984(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057143.1|ensembl:ENSG00000137168(gene)|ensembl:ENST00000373699(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|interpro:IPR044666|rcsb pdb:1XWN|rcsb pdb:2K7N|rcsb pdb:2X7K|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|reactome:R-HSA-72163|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4Wx4abxOz/ayhkwVy/JYzA3d+SE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UHV9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26639	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042683|uniprotkb:Q96FP5|uniprotkb:Q9BWA6|uniprotkb:A8K8I1|ensembl:ENSP00000265112|ensembl:ENSP00000424387|uniprotkb:B4DEG8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sytc_human(display_long)|uniprotkb:TARS1(gene name)|psi-mi:TARS1(display_short)|uniprotkb:TARS(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_689508.3|refseq:NP_001245367.1|rcsb pdb:4HWT|rcsb pdb:4P3N|rcsb pdb:4TTV|rcsb pdb:5XLN|reactome:R-HSA-379716|refseq:NP_001245366.1|go:"GO:0005829"(cytosol)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|ensembl:ENSG00000113407(gene)|interpro:IPR012676(TGS-like)|ensembl:ENST00000265112(transcript)|ensembl:ENST00000502553(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|mint:P26639|rcsb pdb:1WWT	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Z+rOaI1ZO1TQftfkRn1HhXUqDAk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95777	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347779|ensembl:ENSP00000249299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30041	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2255129|uniprotkb:A8JZY7|uniprotkb:P32077|uniprotkb:Q5TAH4|uniprotkb:Q5ZEZ8|ensembl:ENSP00000342026	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx6_human(display_long)|uniprotkb:PRDX6(gene name)|psi-mi:PRDX6(display_short)|uniprotkb:AOP2(gene name synonym)|uniprotkb:KIAA0106(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:24 kDa protein(gene name synonym)|uniprotkb:Liver 2D page spot 40(gene name synonym)|uniprotkb:Red blood cells page spot 12(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004896.1|ensembl:ENSG00000117592(gene)|ensembl:ENST00000340385(transcript)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:1PRX|rcsb pdb:5B6M|rcsb pdb:5B6N|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0042744"(hydrogen peroxide catabolic process)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZMsHgrAJf0VJiCELzo+zSi8Ji+49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21912	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31040	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15366	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945799|uniprotkb:Q6PKG5|intact:EBI-9640573|uniprotkb:Q6IPF4|uniprotkb:B4DXP5|intact:EBI-2555278|uniprotkb:A8K7X6|uniprotkb:F8VYL7|uniprotkb:Q32Q82|uniprotkb:Q68Y55|uniprotkb:I6L8F9|uniprotkb:Q59HD4|uniprotkb:G3V0E8|ensembl:ENSP00000408949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcbp2_human(display_long)|uniprotkb:PCBP2(gene name)|psi-mi:PCBP2(display_short)|uniprotkb:Alpha-CP2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001122383.1|refseq:NP_114366.1|refseq:NP_005007.2|refseq:NP_001092090.1|refseq:NP_001122384.1|refseq:NP_001122385.1|refseq:NP_001122386.1|dip:DIP-58934N|ensembl:ENSG00000197111(gene)|ensembl:ENST00000439930(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15366|rcsb pdb:2AXY|rcsb pdb:2JZX|rcsb pdb:2P2R|rcsb pdb:2PQU|rcsb pdb:2PY9|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-936440	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KWabGhH+pfSX5k0vzs3SXH8Agaw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55072	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P67809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25789	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359310|uniprotkb:Q8TBD1|uniprotkb:Q53XP2|ensembl:ENSP00000044462|ensembl:ENSP00000453887|uniprotkb:D3DW86|uniprotkb:Q567Q5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa4_human(display_long)|uniprotkb:PSMA4(gene name)|psi-mi:PSMA4(display_short)|uniprotkb:PSC9(gene name synonym)|uniprotkb:Proteasome component C9(gene name synonym)|uniprotkb:Macropain subunit C9(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C9(gene name synonym)|uniprotkb:Proteasome subunit L(gene name synonym)|uniprotkb:HC9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001096137.1|refseq:NP_002780.1|rcsb pdb:6XMJ|reactome:R-HSA-2467813|reactome:R-HSA-2871837|rcsb pdb:7AWE|reactome:R-HSA-349425|reactome:R-HSA-1169091|reactome:R-HSA-350562|reactome:R-HSA-1234176|reactome:R-HSA-382556|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-450408|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5358346|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000041357(gene)|ensembl:ENST00000044462(transcript)|ensembl:ENST00000559082(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034647|mint:P25789|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|refseq:NP_001096138.1|refseq:NP_001317605.1|dip:DIP-29365N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u+wKxvIa9JKb4Zu9K+tnY3d26tw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q07955	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y316	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1104564|uniprotkb:Q5R2V9|uniprotkb:Q6NSL5|uniprotkb:D6W575|uniprotkb:B4DLS0|uniprotkb:Q5R2V8|ensembl:ENSP00000385557|ensembl:ENSP00000295065	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:memo1_human(display_long)|uniprotkb:MEMO1(gene name)|psi-mi:MEMO1(display_short)|uniprotkb:CGI-27(orf name)|uniprotkb:Mediator of ErbB2-driven cell motility 1(gene name synonym)|uniprotkb:C2orf4(gene name synonym)|uniprotkb:NS5ATP7(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 7(gene name synonym)|uniprotkb:C21orf19-like protein(gene name synonym)|uniprotkb:MEMO(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001288762.1|refseq:NP_001288781.1|refseq:NP_001131074.1|refseq:NP_057039.1|refseq:XP_011531194.1|refseq:XP_016859744.1|ensembl:ENST00000295065(transcript)|ensembl:ENST00000404530(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0032886"(regulation of microtubule-based process)|interpro:IPR002737(Protein of unknown function DUF52)|rcsb pdb:3BCZ|rcsb pdb:3BD0|reactome:R-HSA-6785631|ensembl:ENSG00000162959(gene)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RL1cWMim2S2Bu+BTlRkdTHnJLxg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07437	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10599	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-594644|uniprotkb:B1ALW1|uniprotkb:O60744|uniprotkb:Q53X69|uniprotkb:Q96KI3|uniprotkb:Q9UDG5|intact:EBI-1042712|ensembl:ENSP00000363641	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:thio_human(display_long)|uniprotkb:ATL-derived factor(gene name synonym)|uniprotkb:Surface-associated sulphydryl protein(gene name synonym)|uniprotkb:TXN(gene name)|psi-mi:TXN(display_short)|uniprotkb:TRDX(gene name synonym)|uniprotkb:TRX(gene name synonym)|uniprotkb:TRX1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003320.2|refseq:NP_001231867.1|dip:DIP-6129N|ensembl:ENSG00000136810(gene)|ensembl:ENST00000374517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006662"(glycerol ether metabolic process)|go:"GO:0009314"(response to radiation)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071731"(response to nitric oxide)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR005746(Thioredoxin)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P10599|rcsb pdb:1AIU|rcsb pdb:1AUC|rcsb pdb:1CQG|rcsb pdb:1CQH|rcsb pdb:1ERT|rcsb pdb:1ERU|rcsb pdb:1ERV|rcsb pdb:1ERW|rcsb pdb:1M7T|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1TRS|rcsb pdb:1TRU|rcsb pdb:1TRV|rcsb pdb:1TRW|rcsb pdb:1W1C|rcsb pdb:1W1E|rcsb pdb:2HSH|rcsb pdb:2HXK|rcsb pdb:2IFQ|rcsb pdb:2IIY|rcsb pdb:3E3E|rcsb pdb:3KD0|rcsb pdb:3M9J|rcsb pdb:3M9K|rcsb pdb:3QFA|rcsb pdb:3QFB|rcsb pdb:3TRX|rcsb pdb:4LL1|rcsb pdb:4LL4|rcsb pdb:4OO4|rcsb pdb:4OO5|rcsb pdb:4POK|rcsb pdb:4POL|rcsb pdb:4POM|rcsb pdb:4PUF|rcsb pdb:4TRX|rcsb pdb:5DQY|reactome:R-HSA-2559580|reactome:R-HSA-3299685|reactome:R-HSA-499943|reactome:R-HSA-5628897|reactome:R-HSA-5676934|reactome:R-HSA-844456|reactome:R-HSA-9617629|reactome:R-HSA-9660826	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5u+iJJtwAwAKXljKHnpY8h5uRkQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62310	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348239|ensembl:ENSP00000302160|uniprotkb:Q9Y4Z1|uniprotkb:Q6IAH0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lsm3_human(display_long)|uniprotkb:MDS017(orf name)|uniprotkb:LSM3(gene name)|psi-mi:LSM3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000170860(gene)|ensembl:ENST00000306024(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0030629"(U6 snRNA 3'-end binding)|go:"GO:0033962"(P-body assembly)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034105|interpro:IPR040002|mint:P62310|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|refseq:NP_055278.1|dip:DIP-31218N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+OnRI9eJcsd1xJe+cUCP7Y/9tt09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00560	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727004|uniprotkb:O43391|ensembl:ENSP00000260130|ensembl:ENSP00000411771|uniprotkb:O00173|uniprotkb:Q14CP2|uniprotkb:B4DUH3|uniprotkb:B7ZLN2|uniprotkb:B2R5Q7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdcb1_human(display_long)|uniprotkb:Scaffold protein Pbp1(gene name synonym)|uniprotkb:Pro-TGF-alpha cytoplasmic domain-interacting protein 18(gene name synonym)|uniprotkb:Syndecan-binding protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 9(gene name synonym)|uniprotkb:SDCBP(gene name)|psi-mi:SDCBP(display_short)|uniprotkb:MDA9(gene name synonym)|uniprotkb:SYCL(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000137575(gene)|ensembl:ENST00000260130(transcript)|ensembl:ENST00000413219(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005109"(frizzled binding)|go:"GO:0005137"(interleukin-5 receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|refseq:NP_001007068.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005895"(interleukin-5 receptor complex)|go:"GO:0005912"(adherens junction)|refseq:NP_001007069.1|refseq:NP_001007070.1|refseq:NP_001007071.1|refseq:NP_005616.2|go:"GO:0005925"(focal adhesion)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030528|interpro:IPR036034|go:"GO:0042802"(identical protein binding)|rcsb pdb:1N99|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:1NTE|go:"GO:0045121"(membrane raft)|rcsb pdb:1OBX|rcsb pdb:1OBY|rcsb pdb:1OBZ|go:"GO:0045202"(synapse)|go:"GO:0045545"(syndecan binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:1R6J|rcsb pdb:1V1T|rcsb pdb:1W9E|rcsb pdb:1W9O|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0099054"(presynapse assembly)|go:"GO:1903543"(positive regulation of exosomal secretion)|rcsb pdb:1W9Q|rcsb pdb:1YBO|rcsb pdb:4Z33|rcsb pdb:6R9H|rcsb pdb:6RLC|reactome:R-HSA-3928664|reactome:R-HSA-447043|reactome:R-HSA-5213460|reactome:R-HSA-6798695|reactome:R-HSA-5675482|dip:DIP-42705N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ys2RNVwH0n5AKA+rBULM9Foxccg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00567	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-396034|uniprotkb:Q2M3T6|uniprotkb:Q9NQ05|ensembl:ENSP00000370589	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nop56_human(display_long)|uniprotkb:NOP56(gene name)|psi-mi:NOP56(display_short)|uniprotkb:NOL5A(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006383.2|ensembl:ENSG00000101361(gene)|ensembl:ENST00000329276(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:O00567|reactome:R-HSA-390471|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nXIsxj5Spl+kflK0yGJFykVylmA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62136	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15126	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055562|uniprotkb:Q5TZW9|ensembl:ENSP00000357452	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pmvk_human(display_long)|uniprotkb:PMVK(gene name)|psi-mi:PMVK(display_short)|uniprotkb:PMKI(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006547.1|ensembl:ENSG00000163344(gene)|ensembl:ENST00000368467(transcript)|go:"GO:0004631"(phosphomevalonate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0019287"(isopentenyl diphosphate biosynthetic process, mevalonate pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070723"(response to cholesterol)|interpro:IPR005919(Higher eukaryotic phosphomevalonate kinase)|interpro:IPR027417|mint:Q15126|rcsb pdb:3CH4|reactome:R-HSA-191273|reactome:R-HSA-2426168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bDsF+xduPQB+HVXbNikncal5foo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05109	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355281|uniprotkb:Q5SY70|uniprotkb:Q9UC92|uniprotkb:Q9UCJ0|uniprotkb:A8K5L3|uniprotkb:Q9UC84|uniprotkb:Q9UCM6|uniprotkb:D3DV37|ensembl:ENSP00000357721|ensembl:ENSP00000357722	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:s10a8_human(display_long)|uniprotkb:S100A8(gene name)|psi-mi:S100A8(display_short)|uniprotkb:CAGA(gene name synonym)|uniprotkb:MRP8(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:S100 calcium-binding protein A8(gene name synonym)|uniprotkb:Calgranulin-A(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 8(gene name synonym)|uniprotkb:Cystic fibrosis antigen(gene name synonym)|uniprotkb:Leukocyte L1 complex light chain(gene name synonym)|uniprotkb:Calprotectin L1L subunit(gene name synonym)|uniprotkb:Urinary stone protein band A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001306126.1|refseq:NP_001306127.1|refseq:NP_001306130.1|refseq:NP_002955.2|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045471"(response to ethanol)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028474|go:"GO:0035662"(Toll-like receptor 4 binding)|mint:P05109|rcsb pdb:1MR8|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5HLO|rcsb pdb:5HLV|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENST00000368732(transcript)|ensembl:ENST00000368733(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|ensembl:ENSG00000143546(gene)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|dip:DIP-1165N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Okfhj8fxclZ0Uo/Fa1Z89qC8Ec9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15286	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722275|uniprotkb:B4E390|uniprotkb:B2R6E0|ensembl:ENSP00000229340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab35_human(display_long)|uniprotkb:Ras-related protein Rab-1C(gene name synonym)|uniprotkb:GTP-binding protein RAY(gene name synonym)|uniprotkb:RAB35(gene name)|psi-mi:RAB35(display_short)|uniprotkb:RAB1C(gene name synonym)|uniprotkb:RAY(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001161078.1|refseq:NP_006852.1|ensembl:ENSG00000111737(gene)|ensembl:ENST00000229340(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042470"(melanosome)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041815|mint:Q15286|rcsb pdb:3TW8|rcsb pdb:6EKK|rcsb pdb:6IF2|rcsb pdb:6IF3|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:95pH+DyDjv9FcxFeMmGYoJ0KyPo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75477	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359299|uniprotkb:B0QZ42|uniprotkb:Q53HV0|ensembl:ENSP00000384900|ensembl:ENSP00000410964|intact:EBI-21351077|uniprotkb:D3DR65	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:erln1_human(display_long)|uniprotkb:KEO4(gene name synonym)|uniprotkb:ERLIN1(gene name)|psi-mi:ERLIN1(display_short)|uniprotkb:C10orf69(gene name synonym)|uniprotkb:KE04(gene name synonym)|uniprotkb:SPFH1(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 1(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1(gene name synonym)|uniprotkb:Protein KE04(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001094096.1|refseq:NP_006450.2|ensembl:ENSG00000107566(gene)|ensembl:ENST00000407654(transcript)|ensembl:ENST00000421367(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O75477|reactome:R-HSA-382556|reactome:R-HSA-5678895|refseq:NP_001334786.1|refseq:NP_001334788.1|refseq:NP_001334789.1|refseq:NP_001334790.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HycFhL5qL5GLmaIIc9NtTcBbu1M9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BUF5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38919	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299104|ensembl:ENSP00000497641|ensembl:ENSP00000497661|uniprotkb:Q15033|uniprotkb:Q96A18|uniprotkb:Q6IBQ2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4a3_human(display_long)|uniprotkb:KIAA0111(gene name synonym)|uniprotkb:EIF4A3(gene name)|psi-mi:EIF4A3(display_short)|uniprotkb:DDX48(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4A isoform 3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DDX48(gene name synonym)|uniprotkb:DEAD box protein 48(gene name synonym)|uniprotkb:Eukaryotic initiation factor 4A-like NUK-34(gene name synonym)|uniprotkb:Nuclear matrix protein 265(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072715"(cellular response to selenite ion)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904570"(negative regulation of selenocysteine incorporation)|go:"GO:1904574"(negative regulation of selenocysteine insertion sequence binding)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P38919|rcsb pdb:2HXY|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:4C9B|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6YVH|rcsb pdb:7A5P|reactome:R-HSA-1169408|reactome:R-HSA-159236|reactome:R-HSA-429947|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|ensembl:ENST00000647795(transcript)|ensembl:ENST00000649764(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|ensembl:ENSG00000141543(gene)|refseq:NP_055555.1|dip:DIP-33218N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8e6e4HlM1GsYqqgXyJ9XgzxLzls9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N5M4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2851213|uniprotkb:Q8WYY7|ensembl:ENSP00000325266|ensembl:ENSP00000434340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ttc9c_human(display_long)|uniprotkb:TTC9C(gene name)|psi-mi:TTC9C(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001305745.1|refseq:NP_776171.1|refseq:NP_001305741.1|refseq:NP_001305742.1|refseq:NP_001305743.1|refseq:NP_001305744.1|ensembl:ENSG00000162222(gene)|ensembl:ENST00000316461(transcript)|ensembl:ENST00000532583(transcript)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IazckGbo0Z5cqr/m7hx7Av7BJlU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60264	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352588|ensembl:ENSP00000283131	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smca5_human(display_long)|uniprotkb:SMARCA5(gene name)|psi-mi:SMARCA5(display_short)|uniprotkb:SNF2H(gene name synonym)|uniprotkb:WCRF135(gene name synonym)|uniprotkb:Sucrose nonfermenting protein 2 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000283131(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016589"(NURF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031213"(RSF complex)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015194(Nucleosome remodelling ATPase ISWI, HAND)|interpro:IPR015195(SLIDE)|interpro:IPR017884|interpro:IPR027417|interpro:IPR036306|interpro:IPR038718|mint:O60264|rcsb pdb:6NE3|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5693565|reactome:R-HSA-606279|refseq:NP_003592.3|ensembl:ENSG00000153147(gene)|dip:DIP-33204N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XlXL5MRhAFlqHhGroPdm01lYEk89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09874	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62140	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15153	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489652|ensembl:ENSP00000249071|uniprotkb:Q9UDJ4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rac2_human(display_long)|uniprotkb:p21-Rac2(gene name synonym)|uniprotkb:Small G protein(gene name synonym)|uniprotkb:GX(gene name synonym)|uniprotkb:RAC2(gene name)|psi-mi:RAC2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045453"(bone resorption)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060753"(regulation of mast cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P15153|rcsb pdb:1DS6|rcsb pdb:2W2T|rcsb pdb:2W2V|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-1222556|go:"GO:0043304"(regulation of mast cell degranulation)|ensembl:ENSG00000128340(gene)|ensembl:ENST00000249071(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0005925"(focal adhesion)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|reactome:R-HSA-1257604|refseq:NP_002863.1|reactome:R-HSA-2219530|reactome:R-HSA-4086400|reactome:R-HSA-5668599|reactome:R-HSA-6811558|reactome:R-HSA-9013404|dip:DIP-34291N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NYkPt/WNmKM3qAhhaufLCPkc/io9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31151	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357520|uniprotkb:Q6FGE3|uniprotkb:Q5SY67|uniprotkb:Q9H1E2|ensembl:ENSP00000357711|ensembl:ENSP00000357712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:s10a7_human(display_long)|uniprotkb:S100A7(gene name)|psi-mi:S100A7(display_short)|uniprotkb:PSOR1(gene name synonym)|uniprotkb:S100A7C(gene name synonym)|uniprotkb:S100 calcium-binding protein A7(gene name synonym)|uniprotkb:Psoriasin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000143556(gene)|ensembl:ENST00000368722(transcript)|ensembl:ENST00000368723(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008544"(epidermis development)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051238"(sequestering of metal ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071624"(positive regulation of granulocyte chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028477|interpro:IPR034325|mint:P31151|rcsb pdb:1PSR|rcsb pdb:2PSR|rcsb pdb:2WND|rcsb pdb:2WOR|rcsb pdb:2WOS|rcsb pdb:3PSR|rcsb pdb:4AQJ|reactome:R-HSA-6798695|reactome:R-HSA-6799990|refseq:NP_002954.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/v8+XQ7rCMTYzq9k/KqjcSm/G0A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63220	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714051|uniprotkb:P35265|ensembl:ENSP00000345957	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs21_human(display_long)|uniprotkb:RPS21(gene name)|psi-mi:RPS21(display_short)|uniprotkb:Small ribosomal subunit protein eS21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000171858(gene)|ensembl:ENST00000343986(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000461"("endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001015.1|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR001931(Ribosomal protein S21e)|interpro:IPR018279|interpro:IPR038579|mint:P63220|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6ZMO|rcsb pdb:6G5H|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6G5I|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:7K5I|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3gi91+fAL7ogzcoJlVEaN4D+87A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13010	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04632	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711828|uniprotkb:Q8WTX3|uniprotkb:Q96EW0|uniprotkb:A8K0P1|ensembl:ENSP00000246533|ensembl:ENSP00000464849	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpns1_human(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:CAPNS1(gene name)|psi-mi:CAPNS1(display_short)|uniprotkb:CAPN4(gene name synonym)|uniprotkb:CAPNS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000126247(gene)|ensembl:ENST00000246533(transcript)|ensembl:ENST00000588815(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|mint:P04632|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:4PHJ|rcsb pdb:4PHK|rcsb pdb:4PHM|rcsb pdb:4WQ2|rcsb pdb:4WQ3|rcsb pdb:5D69|rcsb pdb:6QLB|reactome:R-HSA-1474228|reactome:R-HSA-6809371|reactome:R-HSA-8862803|refseq:NP_001003962.1|refseq:NP_001740.1|refseq:NP_001289561.1|refseq:NP_001289562.1|refseq:XP_005259352.1|refseq:XP_005259353.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:siQugDvaWq0YjOr8qOCf0BsRRKs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-749627|uniprotkb:Q53ZD6|uniprotkb:E1P5N4|ensembl:ENSP00000217402	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:chm4b_human(display_long)|uniprotkb:Chromatin-modifying protein 4b(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 32-2(gene name synonym)|uniprotkb:SNF7-2(gene name synonym)|uniprotkb:SNF7 homolog associated with Alix 1(gene name synonym)|uniprotkb:CHMP4B(gene name)|psi-mi:CHMP4B(display_short)|uniprotkb:C20orf178(gene name synonym)|uniprotkb:SHAX1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_789782.1|dip:DIP-29924N|ensembl:ENSG00000101421(gene)|ensembl:ENST00000217402(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016236"(macroautophagy)|go:"GO:0030117"(membrane coat)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046755"(viral budding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051258"(protein polymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090148"(membrane fission)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR005024(Snf7)|mint:Q9H444|rcsb pdb:3C3Q|rcsb pdb:3UM3|rcsb pdb:4ABM|rcsb pdb:5MK2|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0010824"(regulation of centrosome duplication)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hbJvirD5+L7fxzOoWbiP1ky6c9M9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61604	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711483|uniprotkb:O95421|uniprotkb:Q04984|uniprotkb:Q53X54|ensembl:ENSP00000233893|uniprotkb:Q9UDH0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch10_human(display_long)|uniprotkb:HSPE1(gene name)|psi-mi:HSPE1(display_short)|uniprotkb:10 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 10(gene name synonym)|uniprotkb:Early-pregnancy factor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR020818|interpro:IPR037124|mint:P61604|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|reactome:R-HSA-9013408|ensembl:ENSG00000115541(gene)|ensembl:ENST00000233893(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011032(GroES-like)|interpro:IPR018369|refseq:NP_002148.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BmnGoMnA2QIr3Dr0fElMtTgRztA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02543	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350523|ensembl:ENSP00000222247	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl18a_human(display_long)|uniprotkb:RPL18A(gene name)|psi-mi:RPL18A(display_short)|uniprotkb:Large ribosomal subunit protein eL20(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000971.1|interpro:IPR021138|interpro:IPR023573|interpro:IPR028877|mint:Q02543|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|go:"GO:0097327"(response to antineoplastic agent)|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|ensembl:ENSG00000105640(gene)|ensembl:ENST00000222247(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|rcsb pdb:6ZME|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O9XdW7Let2GcJpJLVuUtatVVv1I9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61158	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351428|uniprotkb:P32391|ensembl:ENSP00000263238|uniprotkb:Q53QM2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arp3_human(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005712.1|ensembl:ENSG00000115091(gene)|ensembl:ENST00000263238(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:P61158|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33140N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46781	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351206|uniprotkb:Q4QRK7|uniprotkb:Q9BVZ0|ensembl:ENSP00000302896|ensembl:ENSP00000375632|ensembl:ENSP00000375633|ensembl:ENSP00000478449|ensembl:ENSP00000479917|ensembl:ENSP00000480135|ensembl:ENSP00000480662|ensembl:ENSP00000481194|ensembl:ENSP00000481553|ensembl:ENSP00000481655|ensembl:ENSP00000481764|ensembl:ENSP00000481822|ensembl:ENSP00000482023|ensembl:ENSP00000482274|ensembl:ENSP00000482338|ensembl:ENSP00000482475|ensembl:ENSP00000483179|ensembl:ENSP00000484394|uniprotkb:A9C4C1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs9_human(display_long)|uniprotkb:RPS9(gene name)|psi-mi:RPS9(display_short)|uniprotkb:Small ribosomal subunit protein uS4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001004.2|refseq:NP_001308630.1|refseq:NP_001308631.1|refseq:NP_001308633.1|ensembl:ENSG00000170889(gene)|ensembl:ENSG00000274005(gene)|ensembl:ENSG00000274626(gene)|ensembl:ENSG00000274646(gene)|ensembl:ENSG00000274950(gene)|ensembl:ENSG00000275323(gene)|ensembl:ENSG00000277079(gene)|ensembl:ENSG00000277359(gene)|ensembl:ENSG00000278081(gene)|ensembl:ENSG00000278270(gene)|ensembl:ENST00000302907(transcript)|ensembl:ENST00000391752(transcript)|ensembl:ENST00000391753(transcript)|ensembl:ENST00000610826(transcript)|ensembl:ENST00000610953(transcript)|ensembl:ENST00000611921(transcript)|ensembl:ENST00000614737(transcript)|ensembl:ENST00000615346(transcript)|ensembl:ENST00000616082(transcript)|ensembl:ENST00000616536(transcript)|ensembl:ENST00000616839(transcript)|ensembl:ENST00000616877(transcript)|ensembl:ENST00000616928(transcript)|ensembl:ENST00000617291(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000618751(transcript)|go:"GO:0005829"(cytosol)|ensembl:ENST00000619229(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|ensembl:ENST00000620720(transcript)|ensembl:ENST00000620940(transcript)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR001912(Ribosomal protein S4)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005710(Ribosomal protein S4/S9, eukaryotic/archaeal)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|interpro:IPR018079|interpro:IPR022801|interpro:IPR036986|mint:P46781|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|go:"GO:0005634"(nucleus)|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|go:"GO:0005654"(nucleoplasm)|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PGNjkKMs8bMMOSOz2AQvwuCvO1A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09211	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353467|uniprotkb:O00460|uniprotkb:Q15690|ensembl:ENSP00000381607|uniprotkb:Q5TZY3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstp1_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short)|uniprotkb:GST3(gene name synonym)|uniprotkb:FAEES3(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:GSTP1-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000843.1|ensembl:ENSG00000084207(gene)|go:"GO:0000302"(response to reactive oxygen species)|ensembl:ENST00000398606(transcript)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0035732"(nitric oxide storage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P09211|rcsb pdb:10GS|rcsb pdb:11GS|rcsb pdb:12GS|rcsb pdb:13GS|rcsb pdb:14GS|rcsb pdb:16GS|rcsb pdb:17GS|rcsb pdb:18GS|rcsb pdb:19GS|rcsb pdb:1AQV|rcsb pdb:1AQW|rcsb pdb:1AQX|rcsb pdb:1EOG|rcsb pdb:1EOH|rcsb pdb:1GSS|rcsb pdb:1KBN|rcsb pdb:1LBK|rcsb pdb:1MD3|rcsb pdb:1MD4|rcsb pdb:1PGT|rcsb pdb:1PX6|rcsb pdb:1PX7|rcsb pdb:1ZGN|rcsb pdb:20GS|rcsb pdb:22GS|rcsb pdb:2A2R|rcsb pdb:2A2S|rcsb pdb:2GSS|rcsb pdb:2J9H|rcsb pdb:2PGT|rcsb pdb:3CSH|rcsb pdb:3CSI|rcsb pdb:3CSJ|rcsb pdb:3DD3|rcsb pdb:3DGQ|rcsb pdb:3GSS|rcsb pdb:3GUS|rcsb pdb:3HJM|rcsb pdb:3HJO|rcsb pdb:3HKR|rcsb pdb:3IE3|rcsb pdb:3KM6|rcsb pdb:3KMN|rcsb pdb:3KMO|rcsb pdb:3N9J|rcsb pdb:3PGT|rcsb pdb:4GSS|rcsb pdb:4PGT|rcsb pdb:5DAK|rcsb pdb:5DAL|rcsb pdb:5DCG|rcsb pdb:5DDL|rcsb pdb:5DJL|rcsb pdb:5DJM|rcsb pdb:5GSS|rcsb pdb:5J41|rcsb pdb:5JCW|rcsb pdb:5L6X|rcsb pdb:5X79|rcsb pdb:6AP9|rcsb pdb:6GSS|rcsb pdb:6LLX|rcsb pdb:6Y1E|rcsb pdb:7GSS|rcsb pdb:8GSS|rcsb pdb:9GSS|reactome:R-HSA-156590|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxqbNusNIvkTg3Cq+7pmygP/EIA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02878	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359655|uniprotkb:Q2M3Q3|uniprotkb:Q8WW97|ensembl:ENSP00000202773|ensembl:ENSP00000403172	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl6_human(display_long)|uniprotkb:RPL6(gene name)|psi-mi:RPL6(display_short)|uniprotkb:TXREB1(gene name synonym)|uniprotkb:Tax-responsive enhancer element-binding protein 107(gene name synonym)|uniprotkb:Neoplasm-related protein C140(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000961.2|refseq:NP_001019833.1|ensembl:ENSG00000089009(gene)|ensembl:ENST00000202773(transcript)|ensembl:ENST00000424576(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR000915(Ribosomal protein L6E)|interpro:IPR005568(Ribosomal protein L6, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041997|mint:Q02878|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001307066.1|refseq:NP_001307067.1|refseq:NP_001307068.1|refseq:NP_001307069.1|refseq:NP_001307070.1|refseq:XP_016875270.1|refseq:XP_016875271.1|dip:DIP-27547N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y7fx3ToInzucV2QmI8KLSdHxai09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23396	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351193|uniprotkb:Q498B5|uniprotkb:Q8NI95|uniprotkb:B2R7N5|ensembl:ENSP00000433821|ensembl:ENSP00000434643|ensembl:ENSP00000436971|uniprotkb:J3KN86	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs3_human(display_long)|uniprotkb:RPS3(gene name)|psi-mi:RPS3(display_short)|uniprotkb:Small ribosomal subunit protein uS3(gene name synonym)|uniprotkb:OK/SW-cl.26(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000996.2|ensembl:ENSG00000149273(gene)|ensembl:ENST00000524851(transcript)|ensembl:ENST00000527446(transcript)|ensembl:ENST00000531188(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032358"(oxidized pyrimidine DNA binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045738"(negative regulation of DNA repair)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061481"(response to TNF agonist)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902546"(positive regulation of DNA N-glycosylase activity)|go:"GO:1905053"(positive regulation of base-excision repair)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR004044(K Homology, type 2)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|go:"GO:0071159"(NF-kappaB complex)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR018280|interpro:IPR036419|mint:P23396|rcsb pdb:1WH9|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|go:"GO:0072686"(mitotic spindle)|go:"GO:0097100"(supercoiled DNA binding)|rcsb pdb:6QZP|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|refseq:NP_001243731.1|refseq:NP_001247436.1|refseq:NP_001247435.1|dip:DIP-33177N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fsDW18AMR3YyEEIhMVcngYRWkps9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62263	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352783|ensembl:ENSP00000311028|ensembl:ENSP00000385425|uniprotkb:P06366|uniprotkb:Q5BJI0|uniprotkb:B2R5G5|uniprotkb:D3DQG5|ensembl:ENSP00000385958|ensembl:ENSP00000428509	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs14_human(display_long)|uniprotkb:RPS14(gene name)|psi-mi:RPS14(display_short)|uniprotkb:Small ribosomal subunit protein uS11(gene name synonym)|uniprotkb:PRO2640(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164587(gene)|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001020242.1|refseq:NP_005608.1|refseq:NP_001020241.1|ensembl:ENST00000312037(transcript)|ensembl:ENST00000401695(transcript)|ensembl:ENST00000407193(transcript)|ensembl:ENST00000521466(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P62263|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ee3bJ5JYFaZXyCCRG9Wooopyz2o9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75179	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355530|uniprotkb:Q6PJ85|uniprotkb:Q6PK85|uniprotkb:Q6PKA2|uniprotkb:Q86XI3|uniprotkb:Q8NDR5|uniprotkb:Q96I86|uniprotkb:Q9H6J9|uniprotkb:Q9H288|ensembl:ENSP00000351416|uniprotkb:G5E964|uniprotkb:E7EUV3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anr17_human(display_long)|uniprotkb:ANKRD17(gene name)|psi-mi:ANKRD17(display_short)|uniprotkb:GTAR(gene name synonym)|uniprotkb:KIAA0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-16(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_115593.3|refseq:NP_942592.1|refseq:NP_056389.1|ensembl:ENSG00000132466(gene)|ensembl:ENST00000358602(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:O75179|go:"GO:0031965"(nuclear membrane)|refseq:NP_001273700.1|ensembl:ENST00000330838|ensembl:ENSP00000332265|ensembl:ENSP00000351416|ensembl:ENST00000509867|ensembl:ENSP00000427151|dip:DIP-47290N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l/gkMCasWF6pn6feuIzeQKWwwKM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PAU2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189929|ensembl:ENSP00000482486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pau2_human(display_long)|uniprotkb:RAVER1(gene name)|psi-mi:RAVER1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000611074(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034633|interpro:IPR034635|interpro:IPR035979|ensembl:ENSG00000161847(gene)|refseq:NP_597709.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:R49B14TFxiQLK5QlLBcHyZQTKD09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60866	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353105|uniprotkb:P17075|uniprotkb:Q5M8S9|uniprotkb:B2R4F4|uniprotkb:B4DW28|ensembl:ENSP00000009589|ensembl:ENSP00000427788|ensembl:ENSP00000503327|ensembl:ENSP00000504123|ensembl:ENSP00000504154|ensembl:ENSP00000504670	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs20_human(display_long)|uniprotkb:RPS20(gene name)|psi-mi:RPS20(display_short)|uniprotkb:Small ribosomal subunit protein uS10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001014.1|refseq:NP_001139699.1|dip:DIP-31245N|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|ensembl:ENSG00000008988(gene)|ensembl:ENST00000009589(transcript)|ensembl:ENST00000521262(transcript)|ensembl:ENST00000676461(transcript)|ensembl:ENST00000676918(transcript)|ensembl:ENST00000678039(transcript)|ensembl:ENST00000678683(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR001848(Ribosomal protein S10)|interpro:IPR005729(Ribosomal protein S10, eukaryotic/archaeal)|interpro:IPR018268|interpro:IPR027486|interpro:IPR036838|mint:P60866|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6xNxX+eP59AOm0KraCysRHUqMFw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27708	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355504|uniprotkb:Q6P0Q0|uniprotkb:D6W552|ensembl:ENSP00000264705|uniprotkb:Q96CK3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pyr1_human(display_long)|uniprotkb:CAD(gene name)|psi-mi:CAD(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004332.2|ensembl:ENSG00000084774(gene)|ensembl:ENST00000264705(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070335"(aspartate binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:P27708|go:"GO:0016020"(membrane)|rcsb pdb:4BY3|rcsb pdb:4C6B|rcsb pdb:4C6C|rcsb pdb:4C6D|rcsb pdb:4C6E|rcsb pdb:4C6F|rcsb pdb:4C6I|rcsb pdb:4C6J|rcsb pdb:4C6K|rcsb pdb:4C6L|rcsb pdb:4C6M|rcsb pdb:4C6N|rcsb pdb:4C6O|rcsb pdb:4C6P|rcsb pdb:4C6Q|rcsb pdb:5G1N|rcsb pdb:5G1O|rcsb pdb:5G1P|rcsb pdb:5YNZ|rcsb pdb:6HFD|rcsb pdb:6HFE|rcsb pdb:6HFF|rcsb pdb:6HFH|rcsb pdb:6HFI|rcsb pdb:6HFJ|rcsb pdb:6HFK|rcsb pdb:6HFL|rcsb pdb:6HFP|rcsb pdb:6HFQ|rcsb pdb:6HFR|rcsb pdb:6HFS|rcsb pdb:6HFU|rcsb pdb:6HG1|reactome:R-HSA-500753|rcsb pdb:6HFN|refseq:NP_001293008.1|dip:DIP-39484N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m5iR4BQz6t2dbQxtP1MARVW0LAw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43633	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2692789|uniprotkb:B2R4W6|uniprotkb:Q3ZTT0|ensembl:ENSP00000310440|ensembl:ENSP00000469240|ensembl:ENSP00000472680	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:chm2a_human(display_long)|uniprotkb:BC2(gene name synonym)|uniprotkb:CHMP2(gene name synonym)|uniprotkb:Chromatin-modifying protein 2a(gene name synonym)|uniprotkb:Putative breast adenocarcinoma marker BC-2(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-1(gene name synonym)|uniprotkb:CHMP2A(gene name)|psi-mi:CHMP2A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055268.1|refseq:NP_940818.1|ensembl:ENSG00000130724(gene)|ensembl:ENST00000312547(transcript)|ensembl:ENST00000600118(transcript)|ensembl:ENST00000601220(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010324"(membrane invagination)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:O43633|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-432720|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-48533N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:S5uZThg//3igYMf6LLYDJ/FVGRA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62753	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356625|uniprotkb:P08227|uniprotkb:P10660|uniprotkb:Q4VBY7|uniprotkb:Q8N6Z7|ensembl:ENSP00000369757	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs6_human(display_long)|uniprotkb:RPS6(gene name)|psi-mi:RPS6(display_short)|uniprotkb:Phosphoprotein NP33(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS6(gene name synonym)|uniprotkb:OK/SW-cl.2(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001001.2|reactome:R-HSA-166208|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR014401(Ribosomal protein S6, eukaryotic)|interpro:IPR018282|mint:P62753|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6F4P|rcsb pdb:6F4Q|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|ensembl:ENSG00000137154(gene)|ensembl:ENST00000380394(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001890"(placenta development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022605"(mammalian oogenesis stage)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0031929"(TOR signaling)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048821"(erythrocyte development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001377(Ribosomal protein S6e)|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|dip:DIP-31507N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:beDuXCIqL99V9JlVfpzx7MdpH689606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07741	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047565|uniprotkb:Q3KP55|uniprotkb:G5E9J2|uniprotkb:Q68DF9|ensembl:ENSP00000367615	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:apt_human(display_long)|uniprotkb:APRT(gene name)|psi-mi:APRT(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000476.1|ensembl:ENSG00000198931(gene)|ensembl:ENST00000378364(transcript)|go:"GO:0002055"(adenine binding)|go:"GO:0003999"(adenine phosphoribosyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006168"(adenine salvage)|go:"GO:0007595"(lactation)|go:"GO:0007625"(grooming behavior)|go:"GO:0016208"(AMP binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0044209"(AMP salvage)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005764(Adenine phosphoribosyl transferase)|interpro:IPR029057|rcsb pdb:1OPU|rcsb pdb:1ORE|rcsb pdb:1ZN7|rcsb pdb:1ZN8|rcsb pdb:1ZN9|rcsb pdb:4X44|rcsb pdb:4X45|rcsb pdb:6FCH|rcsb pdb:6FCI|rcsb pdb:6FCL|rcsb pdb:6FD4|rcsb pdb:6FD5|rcsb pdb:6FD6|rcsb pdb:6HGP|rcsb pdb:6HGQ|rcsb pdb:6HGR|rcsb pdb:6HGS|reactome:R-HSA-6798695|reactome:R-HSA-74217|refseq:NP_001025189.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x046RPUzHysaN5PWMM0UCSyt9xI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61247	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352378|uniprotkb:P33443|uniprotkb:P49241|uniprotkb:B2R4D4|intact:EBI-3440915|uniprotkb:D3DP05|ensembl:ENSP00000346050	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs3a_human(display_long)|uniprotkb:RPS3A(gene name)|psi-mi:RPS3A(display_short)|uniprotkb:MFTL(gene name synonym)|uniprotkb:FTE1(gene name synonym)|uniprotkb:v-fos transformation effector protein(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000997.1|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:4V6X|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000145425(gene)|ensembl:ENST00000274065(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|mint:P61247|rcsb pdb:4UG0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6OM7|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-29408N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:g1TMzz8OFWEuhrRCoecj7KW0qTQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q07020	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352694|intact:EBI-8456577|intact:MINT-8429255|uniprotkb:F8VWC5|uniprotkb:Q8WTZ6|ensembl:ENSP00000447001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl18_human(display_long)|uniprotkb:RPL18(gene name)|psi-mi:RPL18(display_short)|uniprotkb:Large ribosomal subunit protein eL18(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000970.1|ensembl:ENSG00000063177(gene)|ensembl:ENST00000549920(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000039(Ribosomal protein L18e)|interpro:IPR021131|interpro:IPR021132|interpro:IPR036227|mint:Q07020|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001257419.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GgzBcLEQgBqbApFlaQIU2jktkAE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16698	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2554876|uniprotkb:B7Z6B8|uniprotkb:Q93085|uniprotkb:Q2M304|ensembl:ENSP00000220764|intact:EBI-10969978	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:decr_human(display_long)|uniprotkb:DECR(gene name synonym)|uniprotkb:2,4-dienoyl-CoA reductase [NADPH](gene name synonym)|uniprotkb:DECR1(gene name)|psi-mi:DECR1(display_short)|uniprotkb:SDR18C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 18C member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001350.1|ensembl:ENSG00000104325(gene)|ensembl:ENST00000220764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008670"("2,4-dienoyl-CoA reductase (NADPH) activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0070402"(NADPH binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902494"(catalytic complex)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|mint:Q16698|rcsb pdb:1W6U|rcsb pdb:1W73|rcsb pdb:1W8D|reactome:R-HSA-77288|interpro:IPR036291|refseq:NP_001317504.1|refseq:XP_016868636.1|refseq:XP_016868637.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l/8jxdd4pqUIUV2eIThvXTd66yE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63173	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359141|uniprotkb:P23411|uniprotkb:B2R5A8|ensembl:ENSP00000309830|ensembl:ENSP00000390279|ensembl:ENSP00000434243	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl38_human(display_long)|uniprotkb:RPL38(gene name)|psi-mi:RPL38(display_short)|uniprotkb:Large ribosomal subunit protein eL38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000990.1|refseq:NP_001030335.1|ensembl:ENSG00000172809(gene)|ensembl:ENST00000311111(transcript)|ensembl:ENST00000439590(transcript)|ensembl:ENST00000533498(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0033291"(eukaryotic 80S initiation complex)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0048318"(axial mesoderm development)|interpro:IPR002675(Ribosomal protein L38e)|interpro:IPR038464|mint:P63173|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:5AJ0|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6kUSGJll3ldTTRzgVTSwBjgV19Y9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62195	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N	-	-	crc64:29C6410C4A85A7F7	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62244	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347895|ensembl:ENSP00000318646|ensembl:ENSP00000457000|ensembl:ENSP00000458115|ensembl:ENSP00000458528|uniprotkb:P39027|uniprotkb:P39031|uniprotkb:Q3MHD9|uniprotkb:Q8C023|uniprotkb:Q9BV24	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs15a_human(display_long)|uniprotkb:RPS15A(gene name)|psi-mi:RPS15A(display_short)|uniprotkb:Small ribosomal subunit protein uS8(gene name synonym)|uniprotkb:OK/SW-cl.82(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134419(gene)|ensembl:ENST00000322989(transcript)|ensembl:ENST00000563390(transcript)|ensembl:ENST00000565420(transcript)|ensembl:ENST00000572008(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045787"(positive regulation of cell cycle)|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6G4W|interpro:IPR000630(Ribosomal protein S8)|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|interpro:IPR035987|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|mint:P62244|rcsb pdb:4UG0|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:4V6X|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-72695|reactome:R-HSA-975957|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZM7|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|refseq:NP_001010.2|refseq:NP_001025180.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Qdnhk7yvoFFYcRq5kEi7GQILaxs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62424	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354172|uniprotkb:P11518|uniprotkb:Q5T8U4|ensembl:ENSP00000361076|ensembl:ENSP00000487443	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl7a_human(display_long)|uniprotkb:RPL7A(gene name)|psi-mi:RPL7A(display_short)|uniprotkb:SURF-3(gene name synonym)|uniprotkb:SURF3(gene name synonym)|uniprotkb:Surfeit locus protein 3(gene name synonym)|uniprotkb:PLA-X polypeptide(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000963.1|dip:DIP-31502N|ensembl:ENSG00000148303(gene)|ensembl:ENSG00000280858(gene)|ensembl:ENST00000323345(transcript)|ensembl:ENST00000630979(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR001921(Ribosomal protein L7A)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P62424|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|go:"GO:0005634"(nucleus)|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:shPtLmc+oabT/rSwho+tP1iJy4k9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11586	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709638|uniprotkb:Q86VC9|uniprotkb:Q9BVP5|uniprotkb:B2R5Y2|uniprotkb:G3V2B8|intact:EBI-21358459|uniprotkb:A0A024R652|uniprotkb:A0A384N5Y3|ensembl:ENSP00000498336|ensembl:ENSP00000498511	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c1tc_human(display_long)|uniprotkb:MTHFD1(gene name)|psi-mi:MTHFD1(display_short)|uniprotkb:MTHFC(gene name synonym)|uniprotkb:MTHFD(gene name synonym)|uniprotkb:Epididymis secretory sperm binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005947.3|dip:DIP-33682N|ensembl:ENSG00000100714(gene)|ensembl:ENST00000651537(transcript)|ensembl:ENST00000652337(transcript)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR027417|interpro:IPR036291|mint:P11586|rcsb pdb:1A4I|rcsb pdb:1DIA|rcsb pdb:1DIB|rcsb pdb:1DIG|rcsb pdb:6ECP|rcsb pdb:6ECQ|rcsb pdb:6ECR|reactome:R-HSA-196757	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6ZizfpjVcaL5WNxKXL7qJpw59PI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92499	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358474|ensembl:ENSP00000233084|ensembl:ENSP00000370745|ensembl:ENSP00000413767|ensembl:ENSP00000504080|uniprotkb:B4DME8|uniprotkb:B4DPN6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx1_human(display_long)|uniprotkb:DDX1(gene name)|psi-mi:DDX1(display_short)|uniprotkb:DEAD box protein 1(gene name synonym)|uniprotkb:DEAD box protein retinoblastoma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000079785(gene)|ensembl:ENST00000233084(transcript)|ensembl:ENST00000381341(transcript)|ensembl:ENST00000434671(transcript)|ensembl:ENST00000677302(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|refseq:NP_004930.1|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136|mint:Q92499|rcsb pdb:4XW3|reactome:R-HSA-6784531|dip:DIP-38163N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n2Zv07BpuUDT32/ttDzIFXH3yIQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14868	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358730|uniprotkb:Q2TNI3|uniprotkb:Q32Q69|uniprotkb:Q53HV4|uniprotkb:Q53YC5|uniprotkb:Q9BW52|uniprotkb:Q68CR9|uniprotkb:A8K3J2|uniprotkb:D3DP77|ensembl:ENSP00000264161	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sydc_human(display_long)|uniprotkb:DARS1(gene name)|psi-mi:DARS1(display_short)|uniprotkb:Aspartyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 40 protein(gene name synonym)|uniprotkb:DARS(gene name synonym)|uniprotkb:PIG40(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001340.2|refseq:NP_001280241.1|ensembl:ENSG00000115866(gene)|ensembl:ENST00000264161(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006422"(aspartyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0045202"(synapse)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004523(Aspartyl-tRNA synthetase, class IIb, archea/euk type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:P14868|rcsb pdb:4J15|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Yzpil/THkSHGR/ixVyQbV3RZz/E9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39019	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354451|ensembl:ENSP00000469228|ensembl:ENSP00000470004|ensembl:ENSP00000470972	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs19_human(display_long)|uniprotkb:RPS19(gene name)|psi-mi:RPS19(display_short)|uniprotkb:Small ribosomal subunit protein eS19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001013.1|ensembl:ENSG00000105372(gene)|ensembl:ENST00000593863(transcript)|ensembl:ENST00000598742(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003723"(RNA binding)|ensembl:ENST00000600467(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0007000"(nucleolus organization)|go:"GO:0009991"(response to extracellular stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060265"(positive regulation of respiratory burst involved in inflammatory response)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001266(Ribosomal protein S19e)|interpro:IPR018277|interpro:IPR036388|interpro:IPR036390|mint:P39019|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001308412.1|refseq:NP_001308413.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3YqdJJJG+2nqoBf3PLu1fs7pVkY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4E386	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189985	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4e386_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|refseq:NP_001290458.1|refseq:NP_001290459.1|interpro:IPR023123|interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|interpro:IPR037103	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:prJej5wjji2EkLUy3KTAIdRbnnw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13185	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78176|ensembl:ENSP00000336687|ensembl:ENSP00000379670|uniprotkb:Q96CD7|uniprotkb:Q99409|uniprotkb:Q9BVS3|uniprotkb:Q9P0Z6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cbx3_human(display_long)|uniprotkb:CBX3(gene name)|psi-mi:CBX3(display_short)|uniprotkb:Heterochromatin protein 1 homolog gamma(gene name synonym)|uniprotkb:Modifier 2 protein(gene name synonym)|uniprotkb:HECH(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|ensembl:ENSG00000122565(gene)|ensembl:ENST00000337620(transcript)|ensembl:ENST00000396386(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR038033|mint:Q13185|rcsb pdb:2L11|rcsb pdb:3DM1|rcsb pdb:3KUP|rcsb pdb:3TZD|go:"GO:0005637"(nuclear inner membrane)|rcsb pdb:6HW2|reactome:R-HSA-427389|reactome:R-HSA-73772|reactome:R-HSA-8953750|rcsb pdb:5T1I|refseq:NP_009207.2|refseq:NP_057671.2|refseq:XP_005249668.1|dip:DIP-5985N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6L5OQHfxCBkmPV5Z0XihmXx4mFQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P68032	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352273|uniprotkb:P04270|ensembl:ENSP00000290378	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:actc_human(display_long)|uniprotkb:ACTC1(gene name)|psi-mi:ACTC1(display_short)|uniprotkb:ACTC(gene name synonym)|uniprotkb:Alpha-cardiac actin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005150.1|ensembl:ENSG00000159251(gene)|ensembl:ENST00000290378(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0033275"(actin-myosin filament sliding)|go:"GO:0042493"|go:"GO:0044297"(cell body)|go:"GO:0045471"(response to ethanol)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68032|reactome:R-HSA-390522|reactome:R-HSA-8980692|reactome:R-HSA-9013026	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:U/lKYqWUWMSC3fBHFaAcgzfk+3w9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11717	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:C9JNW5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190023|ensembl:ENSP00000420380	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c9jnw5_human(display_long)|uniprotkb:RPL24(gene name)|psi-mi:RPL24(display_short)|uniprotkb:hCG_2023003(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114391(gene)|ensembl:ENST00000469605(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|interpro:IPR000988(Ribosomal protein L24e)|interpro:IPR011017(TRASH)|interpro:IPR023442|interpro:IPR038630	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OE53tm5RMpxZtGwHcVKogk9J89A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-726937|uniprotkb:Q6NZ54|uniprotkb:Q7M4M5|uniprotkb:Q3KQW2|uniprotkb:B2R4H3|uniprotkb:B4E3C2|uniprotkb:B5ME31|uniprotkb:J3QL51|ensembl:ENSP00000462023|ensembl:ENSP00000462385|ensembl:ENSP00000463842|ensembl:ENSP00000480555|ensembl:ENSP00000482577	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl17_human(display_long)|uniprotkb:60S ribosomal protein L23(gene name synonym)|uniprotkb:PD-1(gene name synonym)|uniprotkb:RPL17(gene name)|psi-mi:RPL17(display_short)|uniprotkb:Large ribosomal subunit protein uL22(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000976.1|refseq:NP_001030178.1|refseq:NP_001186269.1|refseq:NP_001186270.1|refseq:NP_001186271.1|refseq:NP_001186272.1|refseq:NP_001186273.1|refseq:NP_001186274.1|ensembl:ENSG00000265681(gene)|ensembl:ENST00000579248(transcript)|ensembl:ENST00000579408(transcript)|ensembl:ENST00000580261(transcript)|ensembl:ENST00000618613(transcript)|ensembl:ENST00000618619(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001063(Ribosomal protein L22/L17)|interpro:IPR005721(Ribosomal protein L22/L17, eukaryotic/archaeal)|interpro:IPR018260|interpro:IPR036394|mint:P18621|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/i0W3WoeFakz+8R/YMYf2JQZytI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62280	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047710|uniprotkb:B2R4F5|uniprotkb:P04643|uniprotkb:Q498Y6|uniprotkb:Q6IRY0|ensembl:ENSP00000270625	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs11_human(display_long)|uniprotkb:RPS11(gene name)|psi-mi:RPS11(display_short)|uniprotkb:Small ribosomal subunit protein uS17(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001006.1|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000266(Ribosomal protein S17)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019979|interpro:IPR028333|interpro:IPR032440|mint:P62280|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|go:"GO:0005840"(ribosome)|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|ensembl:ENSG00000142534(gene)|ensembl:ENST00000270625(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6OM0|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0fqJjtWAuz31VTKt2mbteRoi8vA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62899	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053664|intact:EBI-3867511|uniprotkb:B7Z4K2|uniprotkb:P12947|uniprotkb:Q53SQ5|uniprotkb:Q6LBJ6|uniprotkb:D3DVJ4|uniprotkb:Q6IRZ0|ensembl:ENSP00000264258|ensembl:ENSP00000386681	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl31_human(display_long)|uniprotkb:RPL31(gene name)|psi-mi:RPL31(display_short)|uniprotkb:Large ribosomal subunit protein eL31(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000984.1|refseq:NP_001092047.1|refseq:NP_001093163.1|ensembl:ENSG00000071082(gene)|ensembl:ENST00000264258(transcript)|ensembl:ENST00000409733(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|mint:P62899|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:77LFR7/2somk6blVogZf1XFdJLk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13057	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745967|uniprotkb:Q6GS23|uniprotkb:Q8NBM7|uniprotkb:Q8NEW1|uniprotkb:Q8WXD4|uniprotkb:Q9NRM3|uniprotkb:B2RA78|uniprotkb:B4DLU0|ensembl:ENSP00000377406|ensembl:ENSP00000393564	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:coasy_human(display_long)|uniprotkb:NBP(gene name synonym)|uniprotkb:POV-2(gene name synonym)|uniprotkb:COASY(gene name)|psi-mi:COASY(display_short)|uniprotkb:PSEC0106(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035994.1|refseq:NP_001035997.2|refseq:NP_079509.5|refseq:XP_011523602.1|ensembl:ENSG00000068120(gene)|ensembl:ENST00000393818(transcript)|ensembl:ENST00000421097(transcript)|go:"GO:0004140"(dephospho-CoA kinase activity)|go:"GO:0004595"(pantetheine-phosphate adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001977(Dephospho-CoA kinase)|interpro:IPR004821(Cytidyltransferase-related)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR027417|reactome:R-HSA-196783|refseq:XP_006722179.1|refseq:XP_016880657.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yMK1IODpj01+JZsNsayJCgEHpyo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06576	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18124	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350806|uniprotkb:Q3KQU0|uniprotkb:Q15289|uniprotkb:Q5I0X1|uniprotkb:Q6IBM9|uniprotkb:A8K504|ensembl:ENSP00000339795	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl7_human(display_long)|uniprotkb:RPL7(gene name)|psi-mi:RPL7(display_short)|uniprotkb:Large ribosomal subunit protein uL30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000962.2|ensembl:ENSG00000147604(gene)|ensembl:ENST00000352983(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR018038|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699|mint:P18124|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72689	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:miVEaLOilDYcZXshxJlYbpnzwZ89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NVP1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724378|ensembl:ENSP00000263239|uniprotkb:Q6GTZ9|uniprotkb:Q6IAU4|uniprotkb:Q92732|uniprotkb:Q9BQB7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx18_human(display_long)|uniprotkb:DEAD box protein 18(gene name synonym)|uniprotkb:Myc-regulated DEAD box protein(gene name synonym)|uniprotkb:DDX18(gene name)|psi-mi:DDX18(display_short)|uniprotkb:cPERP-D(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006764.3|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR025313|interpro:IPR027417|interpro:IPR044773|mint:Q9NVP1|rcsb pdb:3LY5|ensembl:ENSG00000088205(gene)|ensembl:ENST00000263239(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0071392"(cellular response to estradiol stimulus)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RmupZbt33/w1V7Uq5vnRO36j2Tc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61160	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353580|ensembl:ENSP00000260641|uniprotkb:O15142|uniprotkb:Q96C82|uniprotkb:B2RCP5|uniprotkb:D6W5F4|uniprotkb:E9PF41	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arp2_human(display_long)|uniprotkb:ACTR2(gene name)|psi-mi:ACTR2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:Actin-like protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000138071(gene)|ensembl:ENST00000260641(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008306"(associative learning)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0016482"(cytosolic transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0030478"(actin cap)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035861"(site of double-strand break)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:NP_001005386.1|refseq:NP_005713.1|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|mint:P61160|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33165N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:URQsZpIsMtsFZAnpLYDDvgKcPqA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00299	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347404|uniprotkb:Q15089|uniprotkb:Q502X1|ensembl:ENSP00000404037|ensembl:ENSP00000404589|ensembl:ENSP00000406088|ensembl:ENSP00000406335|ensembl:ENSP00000406968|ensembl:ENSP00000407429|ensembl:ENSP00000407791|ensembl:ENSP00000408094|ensembl:ENSP00000408357|ensembl:ENSP00000409247|ensembl:ENSP00000409979|ensembl:ENSP00000410965|ensembl:ENSP00000412217|ensembl:ENSP00000413330|ensembl:ENSP00000416211|ensembl:ENSP00000477623|ensembl:ENSP00000478930|ensembl:ENSP00000479501|ensembl:ENSP00000479808|ensembl:ENSP00000480256|ensembl:ENSP00000482255|ensembl:ENSP00000484581|ensembl:ENSP00000364934|ensembl:ENSP00000364935|ensembl:ENSP00000364940|ensembl:ENSP00000372896|ensembl:ENSP00000372897|ensembl:ENSP00000379229|ensembl:ENSP00000382926|ensembl:ENSP00000382931|ensembl:ENSP00000391395|ensembl:ENSP00000398056|ensembl:ENSP00000400280|ensembl:ENSP00000400532|ensembl:ENSP00000401292	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clic1_human(display_long)|uniprotkb:CLIC1(gene name)|psi-mi:CLIC1(display_short)|uniprotkb:NCC27(gene name synonym)|uniprotkb:Nuclear chloride ion channel 27(gene name synonym)|uniprotkb:Chloride channel ABP(gene name synonym)|uniprotkb:Regulatory nuclear chloride ion channel protein(gene name synonym)|uniprotkb:G6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001279.2|refseq:NP_001274522.1|refseq:NP_001274523.1|ensembl:ENST00000375779(transcript)|ensembl:ENST00000375780(transcript)|ensembl:ENST00000375784(transcript)|ensembl:ENST00000383404(transcript)|ensembl:ENST00000383405(transcript)|ensembl:ENST00000395892(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006821"(chloride transport)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030259|go:"GO:0005634"(nucleus)|ensembl:ENSG00000206394(gene)|ensembl:ENSG00000213719(gene)|ensembl:ENSG00000223639(gene)|ensembl:ENSG00000226248(gene)|ensembl:ENSG00000226417(gene)|ensembl:ENSG00000226651(gene)|ensembl:ENSG00000230685(gene)|ensembl:ENST00000400052(transcript)|ensembl:ENST00000400058(transcript)|ensembl:ENST00000415179(transcript)|ensembl:ENST00000418285(transcript)|ensembl:ENST00000420458(transcript)|ensembl:ENST00000422167(transcript)|ensembl:ENST00000423055(transcript)|ensembl:ENST00000423143(transcript)|ensembl:ENST00000423804(transcript)|ensembl:ENST00000425464(transcript)|ensembl:ENST00000431921(transcript)|ensembl:ENST00000433916(transcript)|ensembl:ENST00000434202(transcript)|ensembl:ENST00000435242(transcript)|ensembl:ENST00000438708(transcript)|ensembl:ENST00000438750(transcript)|ensembl:ENST00000442045(transcript)|ensembl:ENST00000447338(transcript)|ensembl:ENST00000447369(transcript)|ensembl:ENST00000451546(transcript)|ensembl:ENST00000456863(transcript)|ensembl:ENST00000457485(transcript)|ensembl:ENST00000614673(transcript)|ensembl:ENST00000614982(transcript)|ensembl:ENST00000616760(transcript)|ensembl:ENST00000618288(transcript)|ensembl:ENST00000619727(transcript)|ensembl:ENST00000621055(transcript)|ensembl:ENST00000622613(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005615"(extracellular space)|interpro:IPR036282|interpro:IPR040079|mint:O00299|interpro:IPR036249|rcsb pdb:1K0M|rcsb pdb:1K0N|rcsb pdb:1K0O|rcsb pdb:1RK4|rcsb pdb:3O3T|rcsb pdb:3P8W|rcsb pdb:3P90|rcsb pdb:3QR6|rcsb pdb:3SWL|rcsb pdb:3TGZ|rcsb pdb:3UVH|rcsb pdb:4IQA|rcsb pdb:4JZQ|rcsb pdb:4K0G|rcsb pdb:4K0N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HVux62IcNdqcPgqmlGlIyZTLpFo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08865	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354112|uniprotkb:Q6NSD1|uniprotkb:Q6NXQ8|uniprotkb:Q86VC0|uniprotkb:P11085|uniprotkb:P12030|uniprotkb:Q16471|uniprotkb:Q6IPD1|uniprotkb:Q6IPD2|ensembl:ENSP00000346067	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rssa_human(display_long)|uniprotkb:RPSA(gene name)|psi-mi:RPSA(display_short)|uniprotkb:LAMBR(gene name synonym)|uniprotkb:LAMR1(gene name synonym)|uniprotkb:Laminin receptor 1(gene name synonym)|uniprotkb:37/67 kDa laminin receptor(gene name synonym)|uniprotkb:Laminin-binding protein precursor p40(gene name synonym)|uniprotkb:Colon carcinoma laminin-binding protein(gene name synonym)|uniprotkb:NEM/1CHD4(gene name synonym)|uniprotkb:Multidrug resistance-associated protein MGr1-Ag(gene name synonym)|uniprotkb:37 kDa laminin receptor precursor(gene name synonym)|uniprotkb:67 kDa laminin receptor(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002286.2|refseq:NP_001291217.1|dip:DIP-32878N|ensembl:ENSG00000168028(gene)|ensembl:ENST00000301821(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0007155"(cell adhesion)|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZOJ|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0043022"(ribosome binding)|go:"GO:0043236"(laminin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001865(Ribosomal protein S2)|interpro:IPR005707(Ribosomal protein S2, eukaryotic/archaeal)|interpro:IPR018130|interpro:IPR023591|interpro:IPR027498|interpro:IPR027504|interpro:IPR032281|mint:P08865|rcsb pdb:3BCH|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Jpv3I3G5C297fHfNwIqyB9Pf8/A9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A5YKK6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222758|uniprotkb:Q68DX7|uniprotkb:Q7Z3K2|uniprotkb:Q8IWB8|uniprotkb:Q8TB53|uniprotkb:Q9BVZ6|uniprotkb:Q9UFR8|uniprotkb:Q9UI27|uniprotkb:Q9Y2L0|intact:EBI-2561986|ensembl:ENSP00000320949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cnot1_human(display_long)|uniprotkb:CNOT1(gene name)|psi-mi:CNOT1(display_short)|uniprotkb:CDC39(gene name synonym)|uniprotkb:KIAA1007(gene name synonym)|uniprotkb:NOT1(gene name synonym)|uniprotkb:Negative regulator of transcription subunit 1 homolog(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:AD-005(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057368.3|refseq:NP_996882.1|refseq:NP_001252541.1|dip:DIP-44954N|ensembl:ENSG00000125107(gene)|ensembl:ENST00000317147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|mint:A5YKK6|rcsb pdb:4C0D|rcsb pdb:4CQO|rcsb pdb:4CRU|rcsb pdb:4CRV|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT6|rcsb pdb:4CT7|rcsb pdb:4GMJ|rcsb pdb:4GML|rcsb pdb:4J8S|rcsb pdb:5ANR|rcsb pdb:5FU6|rcsb pdb:5FU7|rcsb pdb:5ONA|reactome:R-HSA-429947|reactome:R-HSA-6804115	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qYUeacTR9wuDH02Uy8CqCcaaXOY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63104	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26373	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356849|uniprotkb:Q3KQT8|uniprotkb:Q9BPX0|uniprotkb:Q567Q8|uniprotkb:B4DLX3|uniprotkb:F5H1S2|ensembl:ENSP00000307889|ensembl:ENSP00000376811|ensembl:ENSP00000455009	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl13_human(display_long)|uniprotkb:RPL13(gene name)|psi-mi:RPL13(display_short)|uniprotkb:BBC1(gene name synonym)|uniprotkb:Breast basic conserved protein 1(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL13(gene name synonym)|uniprotkb:OK/SW-cl.46(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000968.2|refseq:NP_150254.1|refseq:NP_001230059.1|refseq:NP_001230060.1|ensembl:ENSG00000167526(gene)|ensembl:ENST00000311528(transcript)|ensembl:ENST00000393099(transcript)|ensembl:ENST00000567815(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0060348"(bone development)|interpro:IPR001380(Ribosomal protein L13e)|interpro:IPR018256|mint:P26373|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-192823	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2SZ+AEe41Ystwj9t9I0Z1cZ5GQ49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62277	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351850|uniprotkb:P19116|uniprotkb:Q02546|uniprotkb:Q29200|uniprotkb:Q498Y0|uniprotkb:B2R549|ensembl:ENSP00000435777	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs13_human(display_long)|uniprotkb:RPS13(gene name)|psi-mi:RPS13(display_short)|uniprotkb:Small ribosomal subunit protein uS15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008.1|ensembl:ENSG00000110700(gene)|ensembl:ENST00000525634(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000589(Ribosomal protein S15)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR012606(Ribosomal protein S13/S15, N-terminal)|interpro:IPR023029|mint:P62277|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6OM7|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GmlWYkXKxX6YwpEtzNABb+ZcytI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62888	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353116|uniprotkb:P04645|uniprotkb:Q502Z6|ensembl:ENSP00000287038|ensembl:ENSP00000428085|uniprotkb:B2R591	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl30_human(display_long)|uniprotkb:RPL30(gene name)|psi-mi:RPL30(display_short)|uniprotkb:Large ribosomal subunit protein eL30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000156482(gene)|ensembl:ENST00000287038(transcript)|ensembl:ENST00000521291(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000231(Ribosomal protein L30e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR022991|interpro:IPR029064|interpro:IPR039109|mint:P62888|rcsb pdb:3VI6|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000980.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xR9LwYg6N7m9njT1pYumOPKZVu49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62269	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352451|ensembl:ENSP00000211372|ensembl:ENSP00000393241|ensembl:ENSP00000403175|ensembl:ENSP00000412583|ensembl:ENSP00000416110|uniprotkb:P25232|uniprotkb:Q6IPF8|uniprotkb:Q5SUJ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs18_human(display_long)|uniprotkb:RPS18(gene name)|psi-mi:RPS18(display_short)|uniprotkb:D6S218E(gene name synonym)|uniprotkb:Ke-3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS13(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_072045.1|ensembl:ENSG00000096150(gene)|ensembl:ENSG00000223367(gene)|ensembl:ENSG00000226225(gene)|ensembl:ENSG00000231500(gene)|ensembl:ENSG00000235650(gene)|ensembl:ENST00000211372(transcript)|ensembl:ENST00000434122(transcript)|ensembl:ENST00000439602(transcript)|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENST00000454021(transcript)|ensembl:ENST00000457341(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62269|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|dip:DIP-32892N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yOHgKM/BuvgGdqp1OEVPeuiABg89606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62857	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353027|ensembl:ENSP00000472469|uniprotkb:P25112	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs28_human(display_long)|uniprotkb:RPS28(gene name)|psi-mi:RPS28(display_short)|uniprotkb:Small ribosomal subunit protein eS28(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	mint:P62857|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|ensembl:ENSG00000233927(gene)|ensembl:ENST00000600659(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR000289(Ribosomal protein S28e)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028626|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZM7|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001022.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G4t8mOlzIiHEOXu+uS+AfySWAnM9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00610	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49406	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1188518|uniprotkb:Q96Q52|uniprotkb:Q53TX9|ensembl:ENSP00000377486|ensembl:ENSP00000387284	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rm19_human(display_long)|uniprotkb:MRPL15(gene name synonym)|uniprotkb:39S ribosomal protein L15, mitochondrial(gene name synonym)|uniprotkb:MRPL19(gene name)|psi-mi:MRPL19(display_short)|uniprotkb:KIAA0104(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein bL19m(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055578.2|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7O9M|ensembl:ENSG00000115364(gene)|ensembl:ENST00000393909(transcript)|ensembl:ENST00000409374(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR001857(Ribosomal protein L19)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR038657|mint:P49406|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4ZCZpq3u9wkdpuNVFpk+bhceaW09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4DX78	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4dx78_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:w8STRlDtOptPq7bILJWhcRV5g5E9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61254	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352405|uniprotkb:Q02877|uniprotkb:Q6IPY2|uniprotkb:B2R4F0|uniprotkb:D3DTR8|ensembl:ENSP00000462322|ensembl:ENSP00000463470|ensembl:ENSP00000463784|ensembl:ENSP00000498177	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl26_human(display_long)|uniprotkb:RPL26(gene name)|psi-mi:RPL26(display_short)|uniprotkb:Large ribosomal subunit protein uL24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000978.1|refseq:NP_001302459.1|refseq:NP_001302460.1|ensembl:ENST00000582556(transcript)|ensembl:ENST00000583011(transcript)|ensembl:ENST00000584164(transcript)|ensembl:ENST00000648839(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|ensembl:ENSG00000161970(gene)|go:"GO:0022626"(cytosolic ribosome)|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:1902164"(positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1904803"(regulation of translation involved in cellular response to UV)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005756(Ribosomal protein L26, eukaryotic/archaeal)|interpro:IPR005824(KOW)|interpro:IPR005825(Ribosomal protein L24/L26, conserved site)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041988|mint:P61254|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|go:"GO:0034644"(cellular response to UV)|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|rcsb pdb:5LKS|reactome:R-HSA-156827|dip:DIP-33198N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VAROWOFmYvolVgc/e5E1jAmNuaY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43488	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748855|uniprotkb:O75749|uniprotkb:Q5TG63|ensembl:ENSP00000235835	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ark72_human(display_long)|uniprotkb:AFB1 aldehyde reductase 1(gene name synonym)|uniprotkb:Aldoketoreductase 7(gene name synonym)|uniprotkb:AKR7A2(gene name)|psi-mi:AKR7A2(display_short)|uniprotkb:AFAR(gene name synonym)|uniprotkb:AFAR1(gene name synonym)|uniprotkb:AKR7(gene name synonym)|uniprotkb:Succinic semialdehyde reductase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003680.2|ensembl:ENSG00000053371(gene)|ensembl:ENST00000235835(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0019119"(phenanthrene-9,10-epoxide hydrolase activity)|go:"GO:0044597"(daunorubicin metabolic process)|go:"GO:0044598"(doxorubicin metabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR023210|interpro:IPR036812|rcsb pdb:2BP1|reactome:R-HSA-5423646	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HUJHFlZOl/Xb03VzAZAcmsEHK9o9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07339	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2115097|uniprotkb:Q6IB57|ensembl:ENSP00000236671	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:catd_human(display_long)|uniprotkb:CTSD(gene name)|psi-mi:CTSD(display_short)|uniprotkb:CPSD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001900.1|dip:DIP-43906N|ensembl:ENSG00000117984(gene)|ensembl:ENST00000236671(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033144|mint:P07339|rcsb pdb:1LYA|rcsb pdb:1LYB|rcsb pdb:1LYW|rcsb pdb:4OBZ|rcsb pdb:4OC6|rcsb pdb:4OD9|reactome:R-HSA-1442490|reactome:R-HSA-2022377|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-9018519	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M1qLQBlL2DSCZiAwIPee9Vza3dU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62258	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09668	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189940|ensembl:ENSP00000220166|uniprotkb:B2RBK0|uniprotkb:Q96NY6|uniprotkb:Q9BUM7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cath_human(display_long)|uniprotkb:CTSH(gene name)|psi-mi:CTSH(display_short)|uniprotkb:CPSB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000103811(gene)|ensembl:ENST00000220166(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002764"(immune response-regulating signaling pathway)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060448"(dichotomous subdivision of terminal units involved in lung branching)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0097486"(multivesicular body lumen)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010813"(neuropeptide catabolic process)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030108"(HLA-A specific activating MHC class I receptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031638"(zymogen activation)|go:"GO:0031648"(protein destabilization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0005764"(lysosome)|interpro:IPR039417|rcsb pdb:1BZN|rcsb pdb:6CZK|rcsb pdb:6CZS|reactome:R-HSA-2132295|reactome:R-HSA-5683826|reactome:R-HSA-6798695|interpro:IPR038765|refseq:NP_004381.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tY1fBEZEkMs5w45HHaK5LVO574Q9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:H0YHG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190012|ensembl:ENSP00000447000	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h0yhg0_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000257390(gene)|ensembl:ENST00000546837(transcript)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR032843|interpro:IPR036361|interpro:IPR036869	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Rb4NKPkoUZDm37vByGa9J2Vlbm09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42677	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356336|ensembl:ENSP00000499044|uniprotkb:Q5T4L6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs27_human(display_long)|uniprotkb:RPS27(gene name)|psi-mi:RPS27(display_short)|uniprotkb:MPS1(gene name synonym)|uniprotkb:Metallopan-stimulin 1(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS27(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001021.1|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000177954(gene)|ensembl:ENST00000651669(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407|mint:P42677|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-141444|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-2500257|rcsb pdb:6OM7|reactome:R-HSA-5663220|reactome:R-HSA-6791226|reactome:R-HSA-68877|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-9648025|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-44182N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OA5IWAJDBpY5FFdVnun7Sq/jI7g9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08752	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62750	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353254|uniprotkb:P29316|uniprotkb:Q92774|uniprotkb:P39024|uniprotkb:B2R5B2|ensembl:ENSP00000389103	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl23a_human(display_long)|uniprotkb:RPL23A(gene name)|psi-mi:RPL23A(display_short)|uniprotkb:Large ribosomal subunit protein uL23(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|refseq:NP_000975.2|ensembl:ENSG00000198242(gene)|ensembl:ENST00000422514(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904841"(TORC2 complex binding)|interpro:IPR001014(Ribosomal protein L23, conserved site)|interpro:IPR005633(Ribosomal protein L23/L25, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|interpro:IPR019985|mint:P62750|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lA1ubRFO9/Tl54Z1dKUzoCKvpAo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43447	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355720|uniprotkb:Q6IB85|uniprotkb:Q6NE84|ensembl:ENSP00000300291	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpsf5_human(display_long)|uniprotkb:NUDT21(gene name)|psi-mi:NUDT21(display_short)|uniprotkb:CFIM25(gene name synonym)|uniprotkb:CPSF25(gene name synonym)|uniprotkb:CPSF5(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 25 kDa subunit(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 21(gene name synonym)|uniprotkb:Cleavage factor Im complex 25 kDa subunit(gene name synonym)|uniprotkb:Nudix hydrolase 21(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 68 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_008937.1|ensembl:ENSG00000167005(gene)|ensembl:ENST00000300291(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006397"(mRNA processing)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031439"(positive regulation of mRNA cleavage)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2000975"(positive regulation of pro-B cell differentiation)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR016706(Cleavage and polyadenylation specificity factor, 25 kDa subunit)|mint:O43809|rcsb pdb:2CL3|rcsb pdb:2J8Q|rcsb pdb:3BAP|rcsb pdb:3BHO|rcsb pdb:3MDG|rcsb pdb:3MDI|rcsb pdb:3N9U|rcsb pdb:3P5T|rcsb pdb:3P6Y|rcsb pdb:3Q2S|rcsb pdb:3Q2T|rcsb pdb:5R4P|rcsb pdb:5R4Q|rcsb pdb:5R4R|rcsb pdb:5R4S|rcsb pdb:5R4T|rcsb pdb:5R4U|rcsb pdb:5R64|rcsb pdb:5R65|rcsb pdb:5R66|rcsb pdb:5R67|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|dip:DIP-42502N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Acad4mYVuS+Eox+X2CH8PYUkGAA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00571	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02649	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32969	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358122|ensembl:ENSP00000346022|ensembl:ENSP00000400467|ensembl:ENSP00000494697	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl9_human(display_long)|uniprotkb:RPL9(gene name)|psi-mi:RPL9(display_short)|uniprotkb:RPL9P7(gene name)|psi-mi:RPL9P7(display_short)|uniprotkb:RPL9P8(gene name)|psi-mi:RPL9P8(display_short)|uniprotkb:RPL9P9(gene name)|psi-mi:RPL9P9(display_short)|uniprotkb:Large ribosomal subunit protein uL6(gene name synonym)|uniprotkb:OK/SW-cl.103(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000652.2|refseq:NP_001020092.1|ensembl:ENSG00000163682(gene)|ensembl:ENST00000295955(transcript)|ensembl:ENST00000449470(transcript)|ensembl:ENST00000645496(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR000702(Ribosomal protein L6)|interpro:IPR002359(Ribosomal protein L6, conserved site-2)|interpro:IPR020040|interpro:IPR036789|mint:P32969|rcsb pdb:2CQL|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:v0thFydYo0aEqBblJoqQX8b7JCA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05141	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30050	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352743|uniprotkb:Q6PB27|uniprotkb:Q5VVV2|ensembl:ENSP00000354739	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl12_human(display_long)|uniprotkb:RPL12(gene name)|psi-mi:RPL12(display_short)|uniprotkb:Large ribosomal subunit protein uL11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000967.1|ensembl:ENSG00000197958(gene)|ensembl:ENST00000361436(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P30050|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TNPEtl60cILofaPzUznvZiw6D7E9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8IX12	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356265|ensembl:ENSP00000265872|uniprotkb:A0JLT7|uniprotkb:A1L4P7|uniprotkb:A8K9D4|uniprotkb:B4DNP8|uniprotkb:B4DRK8|uniprotkb:Q5EBM3|uniprotkb:Q32NE3|uniprotkb:Q5VUP6|uniprotkb:Q6PIZ0|uniprotkb:Q6X935|uniprotkb:Q9H8N4|uniprotkb:Q9NVA7|uniprotkb:Q9NVQ0|uniprotkb:Q9NWM6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ccar1_human(display_long)|uniprotkb:CCAR1(gene name)|psi-mi:CCAR1(display_short)|uniprotkb:CARP1(gene name synonym)|uniprotkb:DIS(gene name synonym)|uniprotkb:Cell cycle and apoptosis regulatory protein 1(gene name synonym)|uniprotkb:Death inducer with SAP domain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000060339(gene)|ensembl:ENST00000265872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR011992(EF-Hand type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR036361|mint:Q8IX12|reactome:R-HSA-72163|refseq:NP_060707.2|refseq:NP_001269888.1|refseq:NP_001269889.1|dip:DIP-27607N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YnZve7StC4kAO8raUbp8T02jpe09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62854	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353438|uniprotkb:P02383|uniprotkb:Q3MHD8|uniprotkb:P70394|uniprotkb:Q06722|uniprotkb:Q6IRY4|ensembl:ENSP00000348849|ensembl:ENSP00000450339|ensembl:ENSP00000496643	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs26_human(display_long)|uniprotkb:RPS26(gene name)|psi-mi:RPS26(display_short)|uniprotkb:Small ribosomal subunit protein eS26(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001020.2|refseq:XP_005276741.1|rcsb pdb:6OLG|rcsb pdb:6OLF|ensembl:ENST00000356464(transcript)|ensembl:ENST00000552361(transcript)|ensembl:ENST00000646449(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR000892(Ribosomal protein S26e)|interpro:IPR038551|mint:P62854|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6G5H|ensembl:ENSG00000197728(gene)|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-156827	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bo2ruYMNjjLCMo/kwAWzmlJrrjU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23528	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46782	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350569|uniprotkb:Q96BN0|uniprotkb:B2R4T2|ensembl:ENSP00000196551|ensembl:ENSP00000470114|ensembl:ENSP00000472985	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs5_human(display_long)|uniprotkb:RPS5(gene name)|psi-mi:RPS5(display_short)|uniprotkb:Small ribosomal subunit protein uS7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001000.2|rcsb pdb:6OLZ|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Z6M|rcsb pdb:6XA1|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6Y0G|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:5FLX|rcsb pdb:6OLG|rcsb pdb:6OLI|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|ensembl:ENSG00000083845(gene)|ensembl:ENST00000196551(transcript)|ensembl:ENST00000596046(transcript)|ensembl:ENST00000601521(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823|mint:P46782|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:5AJ0|reactome:R-HSA-72702	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SoCJdf2InngZZtlz5qD1k5CEfEo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6P2E9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62333	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357669|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q6IBU3|uniprotkb:B2R975|ensembl:ENSP00000401802	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prs10_human(display_long)|uniprotkb:PSMC6(gene name)|psi-mi:PSMC6(display_short)|uniprotkb:SUG2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002797.3|ensembl:ENST00000445930(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000100519(gene)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62333|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-75815|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-174184|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|dip:DIP-38150N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QE8jzSEp1bpzhOi/oAAnV18QK249606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42766	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356819|uniprotkb:Q4VBY5|uniprotkb:Q9BYF4|uniprotkb:Q5JTN5|uniprotkb:Q6IBC7|uniprotkb:Q96QJ7|uniprotkb:A8K4V7|ensembl:ENSP00000259469	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl35_human(display_long)|uniprotkb:RPL35(gene name)|psi-mi:RPL35(display_short)|uniprotkb:Large ribosomal subunit protein uL29(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009140.1|ensembl:ENSG00000136942(gene)|ensembl:ENST00000348462(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001854(Ribosomal protein L29)|interpro:IPR018254|interpro:IPR036049|mint:P42766|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jhzt7gCff2vdUb1Ff/VTBF698Pg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15029	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35268	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354533|intact:EBI-1055963|uniprotkb:Q6IBD1|uniprotkb:B2R495|ensembl:ENSP00000346088	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl22_human(display_long)|uniprotkb:RPL22(gene name)|psi-mi:RPL22(display_short)|uniprotkb:Heparin-binding protein HBp15(gene name synonym)|uniprotkb:Epstein-Barr virus small RNA-associated protein(gene name synonym)|uniprotkb:EBER-associated protein(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL22(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000974.1|ensembl:ENSG00000116251(gene)|ensembl:ENST00000234875(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008201"(heparin binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045182"(translation regulator activity)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002671(Ribosomal protein L22e)|interpro:IPR038526|mint:P35268|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|reactome:R-HSA-72706|rcsb pdb:6Z6L|rcsb pdb:6Z6M|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0TVillnqDkHmdTwxIedAJCVAdzY9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07384	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1542113|uniprotkb:Q2TTR0|uniprotkb:Q6DHV4|ensembl:ENSP00000279247|ensembl:ENSP00000431686|ensembl:ENSP00000431984|ensembl:ENSP00000434176|ensembl:ENSP00000435272	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:can1_human(display_long)|uniprotkb:CAPN1(gene name)|psi-mi:CAPN1(display_short)|uniprotkb:CANPL1(gene name synonym)|uniprotkb:Calpain-1 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 1(gene name synonym)|uniprotkb:Calpain mu-type(gene name synonym)|uniprotkb:Micromolar-calpain(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 30 protein(gene name synonym)|uniprotkb:PIG30(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_006718761.1|refseq:NP_001185797.1|refseq:NP_001185798.1|refseq:NP_005177.2|refseq:XP_011543594.1|ensembl:ENSG00000014216(gene)|ensembl:ENST00000279247(transcript)|ensembl:ENST00000524773(transcript)|ensembl:ENST00000527323(transcript)|ensembl:ENST00000533129(transcript)|ensembl:ENST00000533820(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0060056"(mammary gland involution)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097264"(self proteolysis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029643|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P07384|rcsb pdb:1ZCM|rcsb pdb:2ARY|reactome:R-HSA-1474228|reactome:R-HSA-6798695|reactome:R-HSA-6809371|reactome:R-HSA-8862803	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hLf5vu04E7/yonXBb9VIZThbcxk9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12956	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24666	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-717701|uniprotkb:P24667|uniprotkb:Q16035|uniprotkb:Q53RU0|uniprotkb:Q16036|uniprotkb:Q16725|uniprotkb:Q3KQX8|uniprotkb:A8K1L9|uniprotkb:B5MCC7|ensembl:ENSP00000272065	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppac_human(display_long)|uniprotkb:Low molecular weight cytosolic acid phosphatase(gene name synonym)|uniprotkb:Red cell acid phosphatase 1(gene name synonym)|uniprotkb:Adipocyte acid phosphatase(gene name synonym)|uniprotkb:ACP1(gene name)|psi-mi:ACP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004291.1|refseq:NP_009030.1|ensembl:ENSG00000143727(gene)|ensembl:ENST00000272065(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002115(Protein-tyrosine phosphatase, low molecular weight, mammalian)|interpro:IPR017867|interpro:IPR023485|interpro:IPR036196|mint:P24666|rcsb pdb:1XWW|rcsb pdb:3N8I|rcsb pdb:4Z99|rcsb pdb:4Z9A|rcsb pdb:4Z9B|rcsb pdb:5JNR|rcsb pdb:5JNS|rcsb pdb:5JNT|rcsb pdb:5KQG|rcsb pdb:5KQL|rcsb pdb:5KQM|rcsb pdb:5KQP|rcsb pdb:5PNT|rcsb pdb:6Y2V|rcsb pdb:6Y2W|rcsb pdb:7KH8	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:j4VyGaaWO8l/Ah8i1HBU6EnbK289606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5K6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62906	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356860|uniprotkb:P52859|uniprotkb:P53025|uniprotkb:Q5TZT6|uniprotkb:Q8J013|uniprotkb:B2R801|ensembl:ENSP00000363018	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl10a_human(display_long)|uniprotkb:RPL10A(gene name)|psi-mi:RPL10A(display_short)|uniprotkb:NEDD6(gene name synonym)|uniprotkb:CSA-19(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 6(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009035.3|ensembl:ENSG00000198755(gene)|ensembl:ENST00000322203(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673|interpro:IPR023674|interpro:IPR028364|mint:P62906|rcsb pdb:4UG0|rcsb pdb:4V6X|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LU8|rcsb pdb:6OLG|rcsb pdb:6QZP|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wrXKX6vzZ3ovXP3yUoL1/r+NGiw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NX63	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-743375|ensembl:ENSP00000262570	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62701	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354303|uniprotkb:P12631|uniprotkb:P12750|uniprotkb:P27576|uniprotkb:Q14727|uniprotkb:P55831|uniprotkb:Q6IPY4|ensembl:ENSP00000362744	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs4x_human(display_long)|uniprotkb:RPS4X(gene name)|psi-mi:RPS4X(display_short)|uniprotkb:CCG2(gene name synonym)|uniprotkb:RPS4(gene name synonym)|uniprotkb:SCAR(gene name synonym)|uniprotkb:Single copy abundant mRNA protein(gene name synonym)|uniprotkb:SCR10(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000998.1|rcsb pdb:6OLI|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000198034(gene)|ensembl:ENST00000316084(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005824(KOW)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR018199|interpro:IPR032277|interpro:IPR036986|interpro:IPR038237|interpro:IPR041982|mint:P62701|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|go:"GO:0045727"(positive regulation of translation)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2ZuLXqBSDkK0CtN3mnIDoFAR8yI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62266	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353072|ensembl:ENSP00000296674|ensembl:ENSP00000498621|uniprotkb:P39028|uniprotkb:Q6IB08	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs23_human(display_long)|uniprotkb:RPS23(gene name)|psi-mi:RPS23(display_short)|uniprotkb:Small ribosomal subunit protein uS12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000186468(gene)|ensembl:ENST00000296674(transcript)|ensembl:ENST00000651545(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:1990145"(maintenance of translational fidelity)|interpro:IPR005680(Ribosomal protein S23, eukaryotic/archaeal)|interpro:IPR006032(Ribosomal protein S12/S23)|rcsb pdb:5T2C|rcsb pdb:5VYC|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|mint:P62266|rcsb pdb:6G4W|rcsb pdb:4CXG|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:4CXH|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:4UG0|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|refseq:NP_001016.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MWZPvSL/G45ocaxA5AXKCkDQxNU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13838	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348622|uniprotkb:B0S8C0|uniprotkb:Q5STB8|uniprotkb:O43496|uniprotkb:Q0EFA1|uniprotkb:Q2L6F9|uniprotkb:Q53GL9|uniprotkb:Q5RJ64|uniprotkb:Q5RJ66|uniprotkb:Q5ST94|uniprotkb:Q5STB4|uniprotkb:Q5STB5|uniprotkb:Q5STB7|uniprotkb:Q5STU4|uniprotkb:Q5STU5|uniprotkb:Q5STU6|uniprotkb:Q5STU8|uniprotkb:Q71V76|ensembl:ENSP00000373000|ensembl:ENSP00000379475|ensembl:ENSP00000383151|ensembl:ENSP00000383152|ensembl:ENSP00000387994|ensembl:ENSP00000388880|ensembl:ENSP00000390999|ensembl:ENSP00000391463|ensembl:ENSP00000393712|ensembl:ENSP00000394160|ensembl:ENSP00000398775|ensembl:ENSP00000399030|ensembl:ENSP00000400326|ensembl:ENSP00000404695|ensembl:ENSP00000405560|ensembl:ENSP00000407419|ensembl:ENSP00000411136|ensembl:ENSP00000411853|ensembl:ENSP00000416269	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dx39b_human(display_long)|uniprotkb:UAP56(gene name synonym)|uniprotkb:DDX39B(gene name)|psi-mi:DDX39B(display_short)|uniprotkb:DEAD box protein UAP56(gene name synonym)|uniprotkb:56 kDa U2AF65-associated protein(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p47(gene name synonym)|uniprotkb:HLA-B-associated transcript 1 protein(gene name synonym)|uniprotkb:BAT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004631.1|refseq:NP_542165.1|ensembl:ENSG00000198563(gene)|ensembl:ENSG00000215425(gene)|ensembl:ENSG00000225073(gene)|ensembl:ENSG00000225859(gene)|ensembl:ENSG00000229496(gene)|ensembl:ENSG00000230624(gene)|ensembl:ENSG00000235439(gene)|ensembl:ENST00000383508(transcript)|ensembl:ENST00000396172(transcript)|ensembl:ENST00000400295(transcript)|ensembl:ENST00000400296(transcript)|ensembl:ENST00000412106(transcript)|ensembl:ENST00000412330(transcript)|ensembl:ENST00000413678(transcript)|ensembl:ENST00000414440(transcript)|ensembl:ENST00000415689(transcript)|ensembl:ENST00000416863(transcript)|ensembl:ENST00000430784(transcript)|ensembl:ENST00000431360(transcript)|ensembl:ENST00000441425(transcript)|ensembl:ENST00000445218(transcript)|ensembl:ENST00000448296(transcript)|ensembl:ENST00000453138(transcript)|ensembl:ENST00000456476(transcript)|ensembl:ENST00000456666(transcript)|ensembl:ENST00000458640(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000346"(transcription export complex)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0008380"(RNA splicing)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q13838|rcsb pdb:1T5I|rcsb pdb:1T6N|rcsb pdb:1XTI|rcsb pdb:1XTJ|rcsb pdb:1XTK|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9013418	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Cl/rf1oq31fZbLHC2foUXu9MBOE9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00232	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00291	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P84098	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-916524|uniprotkb:P14118|uniprotkb:P22908|uniprotkb:Q502Y6|uniprotkb:Q7Z6E4|uniprotkb:B2R4K2|ensembl:ENSP00000225430	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl19_human(display_long)|uniprotkb:RPL19(gene name)|psi-mi:RPL19(display_short)|uniprotkb:Large ribosomal subunit protein eL19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000972.1|ensembl:ENSG00000108298(gene)|ensembl:ENST00000225430(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000196(Ribosomal protein L19/L19e)|interpro:IPR015972(Ribosomal protein L19/L19e, domain 1)|interpro:IPR023638|interpro:IPR033935|interpro:IPR035970|interpro:IPR039547|mint:P84098|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sYEwdB8ySbxh3iL0uqlfRRVFiWw9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62910	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-438408|ensembl:ENSP00000380156|ensembl:ENSP00000380158|ensembl:ENSP00000388674|ensembl:ENSP00000416429|uniprotkb:P02433|uniprotkb:B2R4Q3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl32_human(display_long)|uniprotkb:RPL32(gene name)|psi-mi:RPL32(display_short)|uniprotkb:Large ribosomal subunit protein eL32(gene name synonym)|uniprotkb:PP9932(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000144713(gene)|ensembl:ENST00000396953(transcript)|ensembl:ENST00000396957(transcript)|ensembl:ENST00000429711(transcript)|ensembl:ENST00000435983(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR001515(Ribosomal protein L32e)|interpro:IPR018263|interpro:IPR036351|mint:P62910|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000985.1|refseq:NP_001007074.1|refseq:NP_001007075.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Yhph2ETzWYd07yJcq1cVqsSRjo9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P67870	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36404	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-752365|uniprotkb:Q9BUK8|uniprotkb:G3V184|ensembl:ENSP00000246747|ensembl:ENSP00000436021	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arl2_human(display_long)|uniprotkb:ARL2(gene name)|psi-mi:ARL2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186674.1|refseq:NP_001658.2|dip:DIP-47535N|ensembl:ENSG00000213465(gene)|ensembl:ENST00000246747(transcript)|ensembl:ENST00000529384(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:P36404|rcsb pdb:3DOE|rcsb pdb:3DOF|reactome:R-HSA-389977|reactome:R-HSA-83936|reactome:R-HSA-9648002	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ArQxx65a8vITU2O0Kr0Qo0hqiqU9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01813	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359022|uniprotkb:B3KS15|uniprotkb:Q5VSR7|uniprotkb:Q5VSR8|ensembl:ENSP00000370517	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfkap_human(display_long)|uniprotkb:PFKP(gene name)|psi-mi:PFKP(display_short)|uniprotkb:PFKF(gene name synonym)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme C(gene name synonym)|uniprotkb:6-phosphofructokinase type C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002618.1|ensembl:ENSG00000067057(gene)|ensembl:ENST00000381125(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:Q01813|rcsb pdb:4RH3|rcsb pdb:4U1R|rcsb pdb:4WL0|rcsb pdb:4XYJ|rcsb pdb:4XYK|rcsb pdb:4XZ2|reactome:R-HSA-70171|refseq:NP_001229268.1|dip:DIP-45850N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GNmWbFrQsTMRdVphWG+3DK3wxaA9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P56385	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2270000|uniprotkb:Q0D2L9|ensembl:ENSP00000306003	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atp5i_human(display_long)|uniprotkb:ATP5ME(gene name)|psi-mi:ATP5ME(display_short)|uniprotkb:ATP5I(gene name synonym)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:ATP5K(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009031.1|ensembl:ENSG00000169020(gene)|ensembl:ENST00000304312(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P56385|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NYpqzWQYASXwSwU/BYDTMU2tJjI9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PAU2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189929|ensembl:ENSP00000482486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pau2_human(display_long)|uniprotkb:RAVER1(gene name)|psi-mi:RAVER1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000611074(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034633|interpro:IPR034635|interpro:IPR035979|ensembl:ENSG00000161847(gene)|refseq:NP_597709.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:R49B14TFxiQLK5QlLBcHyZQTKD09606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P01857	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15559	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189915|imex:IM-17358-2|pride:19290|pride:19291|pride:19293|pride:19292	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	intact-crc:A893B27CE88F0F9D|rigid:Sjc8+Wjuaws8BUOaauN9ZcNhzH4	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14011	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-538850|uniprotkb:B4E2X2|intact:EBI-10980353|uniprotkb:B3KT17|ensembl:ENSP00000322887|ensembl:ENSP00000465779|ensembl:ENSP00000466110|ensembl:ENSP00000466207|ensembl:ENSP00000468788	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cirbp_human(display_long)|uniprotkb:Glycine-rich RNA-binding protein CIRP(gene name synonym)|uniprotkb:A18 hnRNP(gene name synonym)|uniprotkb:CIRBP(gene name)|psi-mi:CIRBP(display_short)|uniprotkb:A18HNRNP(gene name synonym)|uniprotkb:CIRP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001271.1|refseq:XP_006722700.1|refseq:NP_001287744.1|refseq:NP_001287758.1|ensembl:ENSG00000099622(gene)|ensembl:ENST00000320936(transcript)|ensembl:ENST00000585630(transcript)|ensembl:ENST00000586472(transcript)|ensembl:ENST00000588030(transcript)|ensembl:ENST00000588090(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0009409"(response to cold)|go:"GO:0009411"(response to UV)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030371"(translation repressor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:Q14011|rcsb pdb:1X5S|rcsb pdb:5TBX	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nm6/8k5Pw1AnoXsSw9cazJkL49U9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35249	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-476655|uniprotkb:Q6FHX7|ensembl:ENSP00000296273|ensembl:ENSP00000376272|uniprotkb:D3DNV2|uniprotkb:B4DM41	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rfc4_human(display_long)|uniprotkb:Activator 1 subunit 4(gene name synonym)|uniprotkb:Replication factor C 37 kDa subunit(gene name synonym)|uniprotkb:Activator 1 37 kDa subunit(gene name synonym)|uniprotkb:RFC4(gene name)|psi-mi:RFC4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002907.1|refseq:NP_853551.1|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000163918(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|ensembl:ENST00000296273(transcript)|ensembl:ENST00000392481(transcript)|mint:P35249|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|reactome:R-HSA-176187|dip:DIP-24267N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zn+V998ZRpYIdHmG87ExC6LFc0w9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18754	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-992720|uniprotkb:Q16269|uniprotkb:Q6NT97|ensembl:ENSP00000362939|ensembl:ENSP00000381931|ensembl:ENSP00000508074|ensembl:ENSP00000362938	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rcc1_human(display_long)|uniprotkb:Chromosome condensation protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein(gene name synonym)|uniprotkb:RCC1(gene name)|psi-mi:RCC1(display_short)|uniprotkb:CHC1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001041659.1|refseq:NP_001041660.1|refseq:NP_001041664.1|refseq:NP_001260.1|dip:DIP-35416N|ensembl:ENSG00000180198(gene)|ensembl:ENST00000373832(transcript)|ensembl:ENST00000373833(transcript)|ensembl:ENST00000398958(transcript)|ensembl:ENST00000683442(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003682"(chromatin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016032"(viral process)|rcsb pdb:5E1B|rcsb pdb:5E1D|rcsb pdb:5E1M|rcsb pdb:5E1O|rcsb pdb:5E2A|go:"GO:0031267"(small GTPase binding)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031492"(nucleosomal DNA binding)|rcsb pdb:5E2B|rcsb pdb:5TBK|rcsb pdb:6DUB|reactome:R-HSA-165054|go:"GO:0031965"(nuclear membrane)|reactome:R-HSA-180746|reactome:R-HSA-9615933|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:P18754|rcsb pdb:1A12|rcsb pdb:1I2M	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/gP2xQp6fUffHTXpXvs8eb5YJ209606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192381	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00786982|uniparc:UPI0000DD81BA	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:a9ln06-like(display_short)|psi-mi:EBI-6192381(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:It6ePqwtc+lreAAkOHfFSBhsW489606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000059D477|ipi:IPI00641706|ipi:IPI00643158	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6-like(display_short)|psi-mi:EBI-6192365(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wy4rGlQIvXakPLyF0bFYzhvZW/49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192353	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00792850|uniparc:UPI0000E5ADE6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:zyx-like(display_short)|psi-mi:EBI-6192353(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SIOzC91N2HMw+7voQITeRCePuC89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00040897|uniparc:UPI000013DB3E	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd2-like(display_short)|psi-mi:EBI-6192393(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0gMx01VsbQ6zzaL726ZE+OfqtX49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000059D477|ipi:IPI00641706|ipi:IPI00643158	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6-like(display_short)|psi-mi:EBI-6192365(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wy4rGlQIvXakPLyF0bFYzhvZW/49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192387	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000016193E|ipi:IPI00456898	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs12-like(display_short)|psi-mi:EBI-6192387(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.|comment:"Maps to obsolete UniProt_AC (A6NCP0)"	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ef6hwOole2ed/kmvG2tkefUpV+A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00736402|uniparc:UPI00006C1D56	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nog1-like(display_short)|psi-mi:EBI-6192338(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:06I44nYqpH+AFVArCyEzNHAM7zM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53680	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297662|ensembl:ENSP00000263270|uniprotkb:O75977|uniprotkb:Q6PK67|uniprotkb:B2R4Z4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2s1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit sigma(gene name synonym)|uniprotkb:AP2S1(gene name)|psi-mi:AP2S1(display_short)|uniprotkb:Sigma2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 17 kDa protein(gene name synonym)|uniprotkb:HA2 17 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP17(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP17(gene name synonym)|uniprotkb:AP17(gene name synonym)|uniprotkb:CLAPS2(gene name synonym)|uniprotkb:Clathrin assembly protein 2 sigma small chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit sigma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000042753(gene)|ensembl:ENST00000263270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR027156|rcsb pdb:6URI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004060.2|refseq:NP_067586.1|refseq:NP_001288005.1|refseq:NP_001288007.1|refseq:NP_001288010.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AJxHeeoCpwPxjsRcAQkiAGaC9k09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UBQ5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18124	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350806|uniprotkb:Q3KQU0|uniprotkb:Q15289|uniprotkb:Q5I0X1|uniprotkb:Q6IBM9|uniprotkb:A8K504|ensembl:ENSP00000339795	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl7_human(display_long)|uniprotkb:RPL7(gene name)|psi-mi:RPL7(display_short)|uniprotkb:Large ribosomal subunit protein uL30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000962.2|ensembl:ENSG00000147604(gene)|ensembl:ENST00000352983(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR018038|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699|mint:P18124|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72689	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:miVEaLOilDYcZXshxJlYbpnzwZ89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95782	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353552|uniprotkb:Q96CI7|uniprotkb:Q96PP6|uniprotkb:Q96PP7|uniprotkb:Q9H070|intact:EBI-28973302|ensembl:ENSP00000351926	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2a1_human(display_long)|uniprotkb:AP2A1(gene name)|psi-mi:AP2A1(display_short)|uniprotkb:ADTAA(gene name synonym)|uniprotkb:CLAPA1(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055018.2|refseq:NP_570603.2|ensembl:ENST00000354293|ensembl:ENSP00000346246|ensembl:ENSP00000351926|ensembl:ENSG00000196961(gene)|ensembl:ENST00000359032(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O95782|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|dip:DIP-33164N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:egkaIAhvIi1FqNr+8KEFeJaYZcc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P47756	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353595|uniprotkb:Q5U0L4|uniprotkb:Q8TB49|uniprotkb:Q9NUC4|uniprotkb:Q32Q68|ensembl:ENSP00000364284|ensembl:ENSP00000501528	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:capzb_human(display_long)|uniprotkb:CAPZB(gene name)|psi-mi:CAPZB(display_short)|uniprotkb:CapZ beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001193469.1|refseq:NP_004921.1|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|mint:P47756|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-9013405|reactome:R-HSA-9035034|reactome:R-HSA-9662360|reactome:R-HSA-983231|ensembl:ENSG00000077549(gene)|ensembl:ENST00000375142(transcript)|ensembl:ENST00000674432(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030863"(cortical cytoskeleton)|refseq:NP_001269091.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qRXsrB2fLT1DMVIVRWKFYe4Aln49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22681	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NSD9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353803|uniprotkb:B4DFM0|uniprotkb:O95708|uniprotkb:Q9NZZ6|uniprotkb:Q4ZFX1|uniprotkb:Q57ZJ5|ensembl:ENSP00000281828	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syfb_human(display_long)|uniprotkb:FARSB(gene name)|psi-mi:FARSB(display_short)|uniprotkb:FARSLB(gene name synonym)|uniprotkb:FRSB(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase beta subunit(gene name synonym)|uniprotkb:HSPC173(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005678.3|refseq:XP_006712232.1|refseq:XP_011508768.1|ensembl:ENSG00000116120(gene)|ensembl:ENST00000281828(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR004531(Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR005147(tRNA synthetase, B5)|interpro:IPR009061(Putative DNA binding)|interpro:IPR020825|interpro:IPR040659|interpro:IPR041616|rcsb pdb:3L4G|reactome:R-HSA-379716|refseq:XP_016858599.1|dip:DIP-32869N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YgMUMEiw+jAUaDK5KomMWi66vn09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39019	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354451|ensembl:ENSP00000469228|ensembl:ENSP00000470004|ensembl:ENSP00000470972	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs19_human(display_long)|uniprotkb:RPS19(gene name)|psi-mi:RPS19(display_short)|uniprotkb:Small ribosomal subunit protein eS19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001013.1|ensembl:ENSG00000105372(gene)|ensembl:ENST00000593863(transcript)|ensembl:ENST00000598742(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003723"(RNA binding)|ensembl:ENST00000600467(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0007000"(nucleolus organization)|go:"GO:0009991"(response to extracellular stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060265"(positive regulation of respiratory burst involved in inflammatory response)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001266(Ribosomal protein S19e)|interpro:IPR018277|interpro:IPR036388|interpro:IPR036390|mint:P39019|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001308412.1|refseq:NP_001308413.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3YqdJJJG+2nqoBf3PLu1fs7pVkY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15149	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297903|intact:EBI-1103289|intact:EBI-1103265|intact:EBI-1055056|uniprotkb:Q15148|uniprotkb:Q16640|ensembl:ENSP00000323856|uniprotkb:Q6S376|intact:EBI-28976159|uniprotkb:Q6S380|intact:EBI-1103313|uniprotkb:Q6S377|uniprotkb:Q6S378|uniprotkb:Q6S379|intact:EBI-1103301|intact:EBI-1103253|uniprotkb:Q6S381|uniprotkb:Q6S382|uniprotkb:Q6S383|intact:EBI-2825763	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:plec_human(display_long)|uniprotkb:PLEC(gene name)|psi-mi:PLEC(display_short)|uniprotkb:Hemidesmosomal protein 1(gene name synonym)|uniprotkb:PLEC1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000178209(gene)|ensembl:ENST00000322810(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0120193"(tight junction organization)|go:"GO:2000689"(actomyosin contractile ring assembly actin filament organization)|go:"GO:2000983"(regulation of ATP citrate synthase activity)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR005326(Plectin/S10, N-terminal)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006997"(nucleus organization)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016569"(obsolete covalent chromatin modification)|go:"GO:0019226"(transmission of nerve impulse)|interpro:IPR030269|interpro:IPR035915|interpro:IPR018159|interpro:IPR036388|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q15149|rcsb pdb:1MB8|rcsb pdb:2N03|rcsb pdb:2ODU|rcsb pdb:2ODV|rcsb pdb:3F7P|rcsb pdb:3PDY|rcsb pdb:3PE0|rcsb pdb:4GDO|rcsb pdb:4Q58|rcsb pdb:4Q59|rcsb pdb:5J1F|rcsb pdb:5J1G|rcsb pdb:5J1H|rcsb pdb:5J1I|reactome:R-HSA-2022090|reactome:R-HSA-264870|reactome:R-HSA-446107|ensembl:ENST00000436759|ensembl:ENSP00000388180|ensembl:ENST00000527096|ensembl:ENSP00000434583|ensembl:ENSP00000323856|ensembl:ENST00000345136|ensembl:ENSP00000344848|ensembl:ENST00000354589|ensembl:ENSP00000346602|ensembl:ENST00000354958|ensembl:ENSP00000347044|ensembl:ENST00000356346|ensembl:ENSP00000348702|ensembl:ENST00000357649|ensembl:ENSP00000350277|ensembl:ENST00000398774|ensembl:ENSP00000381756|refseq:NP_000436.2|refseq:NP_958780.1|refseq:NP_958781.1|refseq:NP_958782.1|refseq:NP_958783.1|refseq:NP_958784.1|refseq:NP_958785.1|refseq:NP_958786.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zbctDAOOCaJUx3WBdp85v7SI0sI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11142	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78344	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-296519|uniprotkb:O60877|uniprotkb:P78404|uniprotkb:Q0VH00|uniprotkb:Q53EU1|uniprotkb:Q58EZ2|uniprotkb:Q8NI71|uniprotkb:Q96C16|ensembl:ENSP00000340281|ensembl:ENSP00000433371|ensembl:ENSP00000433664|uniprotkb:Q0VH01|uniprotkb:Q2NKW9|uniprotkb:Q49A79	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4g2_human(display_long)|uniprotkb:EIF4G2(gene name)|psi-mi:EIF4G2(display_short)|uniprotkb:DAP5(gene name synonym)|uniprotkb:OK/SW-cl.75(orf name)|uniprotkb:p97(gene name synonym)|uniprotkb:Death-associated protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000110321(gene)|ensembl:ENST00000339995(transcript)|ensembl:ENST00000525681(transcript)|ensembl:ENST00000526148(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007507"(heart development)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008219"(cell death)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:P78344|rcsb pdb:3D3M|rcsb pdb:3L6A|rcsb pdb:4IUL|reactome:R-HSA-1169408|refseq:NP_001036024.3|refseq:NP_001166176.1|refseq:NP_001409.3|dip:DIP-31366N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UIE1Um0s2KJ9hpaa9X6kfZ8enPc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y316	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1104564|uniprotkb:Q5R2V9|uniprotkb:Q6NSL5|uniprotkb:D6W575|uniprotkb:B4DLS0|uniprotkb:Q5R2V8|ensembl:ENSP00000385557|ensembl:ENSP00000295065	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:memo1_human(display_long)|uniprotkb:MEMO1(gene name)|psi-mi:MEMO1(display_short)|uniprotkb:CGI-27(orf name)|uniprotkb:Mediator of ErbB2-driven cell motility 1(gene name synonym)|uniprotkb:C2orf4(gene name synonym)|uniprotkb:NS5ATP7(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 7(gene name synonym)|uniprotkb:C21orf19-like protein(gene name synonym)|uniprotkb:MEMO(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001288762.1|refseq:NP_001288781.1|refseq:NP_001131074.1|refseq:NP_057039.1|refseq:XP_011531194.1|refseq:XP_016859744.1|ensembl:ENST00000295065(transcript)|ensembl:ENST00000404530(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0032886"(regulation of microtubule-based process)|interpro:IPR002737(Protein of unknown function DUF52)|rcsb pdb:3BCZ|rcsb pdb:3BD0|reactome:R-HSA-6785631|ensembl:ENSG00000162959(gene)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RL1cWMim2S2Bu+BTlRkdTHnJLxg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43395	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04406	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26358	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62424	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354172|uniprotkb:P11518|uniprotkb:Q5T8U4|ensembl:ENSP00000361076|ensembl:ENSP00000487443	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl7a_human(display_long)|uniprotkb:RPL7A(gene name)|psi-mi:RPL7A(display_short)|uniprotkb:SURF-3(gene name synonym)|uniprotkb:SURF3(gene name synonym)|uniprotkb:Surfeit locus protein 3(gene name synonym)|uniprotkb:PLA-X polypeptide(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000963.1|dip:DIP-31502N|ensembl:ENSG00000148303(gene)|ensembl:ENSG00000280858(gene)|ensembl:ENST00000323345(transcript)|ensembl:ENST00000630979(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR001921(Ribosomal protein L7A)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P62424|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|go:"GO:0005634"(nucleus)|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:shPtLmc+oabT/rSwho+tP1iJy4k9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13347	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354047|intact:EBI-11759480|ensembl:ENSP00000504034|ensembl:ENSP00000504061|ensembl:ENSP00000502867|ensembl:ENSP00000503348|ensembl:ENSP00000503539	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3i_human(display_long)|uniprotkb:EIF3I(gene name)|psi-mi:EIF3I(display_short)|uniprotkb:TRIP1(gene name synonym)|uniprotkb:EIF3S2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 2(gene name synonym)|uniprotkb:eIF-3-beta(gene name synonym)|uniprotkb:eIF3 p36(gene name synonym)|uniprotkb:TGF-beta receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003748.1|ensembl:ENST00000676801(transcript)|ensembl:ENST00000677202(transcript)|ensembl:ENST00000677701(transcript)|ensembl:ENST00000677711(transcript)|ensembl:ENST00000677760(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|ensembl:ENSG00000084623(gene)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027525|interpro:IPR036322|mint:Q13347|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31116N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fogC6nSNmIynV2ziHZboT9laA3M9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9HAV4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99848	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048111|uniprotkb:Q96A66|ensembl:ENSP00000236051	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ebp2_human(display_long)|uniprotkb:EBNA1-binding protein 2(gene name synonym)|uniprotkb:Nucleolar protein p40(gene name synonym)|uniprotkb:EBNA1BP2(gene name)|psi-mi:EBNA1BP2(display_short)|uniprotkb:EBP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153408.1|refseq:NP_006815.2|ensembl:ENSG00000117395(gene)|ensembl:ENST00000236051(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR008610(Eukaryotic rRNA processing)|mint:Q99848|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lUFbxBko/pJHiNq8uuefmK3Xqp89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02545	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92499	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358474|ensembl:ENSP00000233084|ensembl:ENSP00000370745|ensembl:ENSP00000413767|ensembl:ENSP00000504080|uniprotkb:B4DME8|uniprotkb:B4DPN6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx1_human(display_long)|uniprotkb:DDX1(gene name)|psi-mi:DDX1(display_short)|uniprotkb:DEAD box protein 1(gene name synonym)|uniprotkb:DEAD box protein retinoblastoma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000079785(gene)|ensembl:ENST00000233084(transcript)|ensembl:ENST00000381341(transcript)|ensembl:ENST00000434671(transcript)|ensembl:ENST00000677302(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|refseq:NP_004930.1|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136|mint:Q92499|rcsb pdb:4XW3|reactome:R-HSA-6784531|dip:DIP-38163N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n2Zv07BpuUDT32/ttDzIFXH3yIQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13492	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2803688|uniprotkb:Q86XZ9|uniprotkb:O60700|uniprotkb:Q6GMQ6|intact:EBI-28967113|ensembl:ENSP00000377015|uniprotkb:B4DTM3|uniprotkb:E9PN05|uniprotkb:F8VPG7|uniprotkb:Q4LE54	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pical_human(display_long)|uniprotkb:CALM(gene name synonym)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:PICALM(gene name)|psi-mi:PICALM(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000356360|ensembl:ENSP00000348718|ensembl:ENSP00000377015|ensembl:ENST00000526033|ensembl:ENSP00000433846|ensembl:ENST00000528398|ensembl:ENSP00000434884|ensembl:ENST00000532317|ensembl:ENSP00000436958|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0005634"(nucleus)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR030412|mint:Q13492|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9696264|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0032050"(clathrin heavy chain binding)|ensembl:ENSG00000073921(gene)|ensembl:ENST00000393346(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:0055072"(iron ion homeostasis)|refseq:NP_001008660.1|refseq:NP_001193875.1|refseq:NP_001193876.1|refseq:NP_009097.2|refseq:XP_005274388.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UIZhYyYqmBCyN4xwPCl9PeCdK8Q9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53992	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-81134|uniprotkb:Q8WV25|ensembl:ENSP00000321845|ensembl:ENSP00000343405|uniprotkb:B4DZT4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc24c_human(display_long)|uniprotkb:SEC24C(gene name)|psi-mi:SEC24C(display_short)|uniprotkb:KIAA0079(gene name synonym)|uniprotkb:SEC24-related protein C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR041742|mint:P53992|rcsb pdb:3EH2|rcsb pdb:6PU1|reactome:R-HSA-1655829|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-983170|reactome:R-HSA-5694530|ensembl:ENSG00000176986(gene)|ensembl:ENST00000339365(transcript)|ensembl:ENST00000345254(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030127"(COPII vesicle coat)|refseq:NP_004913.2|refseq:NP_940999.1|dip:DIP-30981N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kOKJkIWFOlIpRFLj5JshAGqAg6s9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62269	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352451|ensembl:ENSP00000211372|ensembl:ENSP00000393241|ensembl:ENSP00000403175|ensembl:ENSP00000412583|ensembl:ENSP00000416110|uniprotkb:P25232|uniprotkb:Q6IPF8|uniprotkb:Q5SUJ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs18_human(display_long)|uniprotkb:RPS18(gene name)|psi-mi:RPS18(display_short)|uniprotkb:D6S218E(gene name synonym)|uniprotkb:Ke-3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS13(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_072045.1|ensembl:ENSG00000096150(gene)|ensembl:ENSG00000223367(gene)|ensembl:ENSG00000226225(gene)|ensembl:ENSG00000231500(gene)|ensembl:ENSG00000235650(gene)|ensembl:ENST00000211372(transcript)|ensembl:ENST00000434122(transcript)|ensembl:ENST00000439602(transcript)|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENST00000454021(transcript)|ensembl:ENST00000457341(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62269|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|dip:DIP-32892N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yOHgKM/BuvgGdqp1OEVPeuiABg89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06730	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73440|uniprotkb:Q96E95|ensembl:ENSP00000389624|uniprotkb:D6RCQ6|uniprotkb:B7Z6V1|intact:EBI-28969298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4e_human(display_long)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:EIF4E(gene name)|psi-mi:EIF4E(display_short)|uniprotkb:EIF4EL1(gene name synonym)|uniprotkb:EIF4F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001124151.1|refseq:NP_001959.1|ensembl:ENST00000280892|ensembl:ENSP00000280892|ensembl:ENSP00000389624|ensembl:ENST00000505992|ensembl:ENSP00000425561|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:2W97|rcsb pdb:3AM7|rcsb pdb:3TF2|rcsb pdb:3U7X|rcsb pdb:4AZA|rcsb pdb:4BEA|rcsb pdb:4DT6|rcsb pdb:4DUM|rcsb pdb:4TPW|rcsb pdb:4TQB|rcsb pdb:4TQC|rcsb pdb:4UED|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5EKV|rcsb pdb:5GW6|rcsb pdb:5T46|rcsb pdb:5ZJY|rcsb pdb:5ZJZ|rcsb pdb:5ZK5|rcsb pdb:5ZK7|rcsb pdb:5ZK9|ensembl:ENSG00000151247(gene)|rcsb pdb:5ZML|rcsb pdb:7MEU|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-159231|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-159230|reactome:R-HSA-159227|ensembl:ENST00000450253(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|mint:P06730|rcsb pdb:1IPB|rcsb pdb:1IPC|rcsb pdb:1WKW|rcsb pdb:2GPQ|rcsb pdb:2V8W|refseq:NP_001124150.1|refseq:NP_001317946.1|dip:DIP-22N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9173bxjOdBfKj36pWVvzw7M6g1A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14157	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53990	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945994|intact:EBI-4324656|uniprotkb:A8KAH5|uniprotkb:Q9BQ81|uniprotkb:Q9BWN2|uniprotkb:Q3SYM4|uniprotkb:J3QLU7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ist1_human(display_long)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Putative MAPK-activating protein PM28(gene name synonym)|uniprotkb:KIAA0174(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055576.2|refseq:NP_001257904.1|refseq:NP_001257906.1|refseq:NP_001257905.1|refseq:NP_001257907.1|mint:P53990|dip:DIP-42546N|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0009838"(abscission)|go:"GO:0015031"(protein transport)|go:"GO:0019076"(viral release from host cell)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046745"(viral capsid secondary envelopment)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:0090543"(Flemming body)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3FRR|rcsb pdb:3FRS|rcsb pdb:3JC1|rcsb pdb:4U7E|rcsb pdb:4U7I|rcsb pdb:4U7Y|rcsb pdb:4WZX|rcsb pdb:6E8G|rcsb pdb:6TZ4|rcsb pdb:6TZ5|rcsb pdb:6TZA|reactome:R-HSA-6798695|reactome:R-HSA-9668328	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RbWwKZ+sftO2x3UkFz8zAxVi2CU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13224	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2833037|uniprotkb:Q8NG40|uniprotkb:Q14422|ensembl:ENSP00000383382	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gp1bb_human(display_long)|uniprotkb:GP1BB(gene name)|psi-mi:GP1BB(display_short)|uniprotkb:Antigen CD42b-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000398.1|ensembl:ENSG00000203618(gene)|ensembl:ENST00000366425(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0042802"(identical protein binding)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR032675|mint:P13224|rcsb pdb:3REZ|rcsb pdb:3RFE|reactome:R-HSA-140837|reactome:R-HSA-430116|reactome:R-HSA-75892|reactome:R-HSA-76009|reactome:R-HSA-9673221	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eD4E+gbGDmXWJhX5W8jNjLLy0d89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NVI7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IZKJEVLLS/DFINgBgO5frizN1P49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05198	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056162|ensembl:ENSP00000256383|ensembl:ENSP00000425299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2a_human(display_long)|uniprotkb:EIF2S1(gene name)|psi-mi:EIF2S1(display_short)|uniprotkb:EIF2A(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004085.1|ensembl:ENSG00000134001(gene)|ensembl:ENST00000256383(transcript)|ensembl:ENST00000466499(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|mint:P05198|rcsb pdb:1KL9|rcsb pdb:1Q8K|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|dip:DIP-39418N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hG3fLbQuFpe5z8zS/bt/TnpEpzA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99729	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044873|uniprotkb:Q04150|uniprotkb:Q8N7U3|uniprotkb:Q9BQ99|intact:EBI-2339961|uniprotkb:B3KNN5|uniprotkb:D3DWP7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roaa_human(display_long)|uniprotkb:HNRPAB(gene name synonym)|uniprotkb:APOBEC1-binding protein 1(gene name synonym)|uniprotkb:HNRNPAB(gene name)|psi-mi:HNRNPAB(display_short)|uniprotkb:ABBP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004490.2|refseq:NP_112556.2|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR034846|interpro:IPR035979|rcsb pdb:3S7R|mint:Q99729|dip:DIP-50394N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NzusDKSvcoVb90LNvXpaMAvg0Oo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96PU8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945792|uniprotkb:Q2I375|uniprotkb:Q5MJQ1|uniprotkb:Q969L9|uniprotkb:Q96EJ3|uniprotkb:Q96KA3|uniprotkb:Q96PU6|uniprotkb:Q96PU7|uniprotkb:Q9P0X6|uniprotkb:Q9P0X7|uniprotkb:Q9P0X8|uniprotkb:Q9P0X9|uniprotkb:Q9P0Y0|uniprotkb:Q9P0Y1|ensembl:ENSP00000355094	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:qki_human(display_long)|uniprotkb:QKI(gene name)|psi-mi:QKI(display_short)|uniprotkb:HKQ(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006766.1|refseq:NP_996735.1|refseq:NP_996736.1|refseq:NP_996737.1|refseq:NP_001288014.1|refseq:XP_011534561.1|ensembl:ENSG00000112531(gene)|ensembl:ENST00000361752(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0007286"(spermatid development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042552"(myelination)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0045202"(synapse)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032367|interpro:IPR032377|interpro:IPR036612|mint:Q96PU8|rcsb pdb:4JVH|reactome:R-HSA-6802952	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7dcw5OyNAhQTE+yTch3qbSlZJdE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55060	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15717	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374260|uniprotkb:Q9BTT1|ensembl:ENSP00000385269|ensembl:ENSP00000472197|intact:EBI-6190219|uniprotkb:B4DVB8|uniprotkb:Q53XN6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:elav1_human(display_long)|uniprotkb:ELAVL1(gene name)|psi-mi:ELAVL1(display_short)|uniprotkb:HUR(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|ensembl:ENSG00000066044(gene)|ensembl:ENST00000407627(transcript)|ensembl:ENST00000596459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|refseq:NP_001410.2|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:Q15717|rcsb pdb:3HI9|rcsb pdb:4ED5|rcsb pdb:4EGL|rcsb pdb:4FXV|rcsb pdb:5SZW|rcsb pdb:6G2K|rcsb pdb:6GC5|rcsb pdb:6GD1|rcsb pdb:6GD2|rcsb pdb:6GD3|reactome:R-HSA-450520|reactome:R-HSA-72163|dip:DIP-31291N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PciL5KuvP+2aUUv9cv7gWScgbw89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14980	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WXE9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-539742|uniprotkb:Q6NT47|uniprotkb:Q96RI7|uniprotkb:Q96RU6|uniprotkb:Q17R24|uniprotkb:G3V2T7|uniprotkb:Q59H11|intact:EBI-28967360	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ston2_human(display_long)|uniprotkb:Stoned B(gene name synonym)|uniprotkb:STON2(gene name)|psi-mi:STON2(display_short)|uniprotkb:STNB(gene name synonym)|uniprotkb:STN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR017110(Stonin)|ensembl:ENST00000555447|ensembl:ENSP00000450857|ensembl:ENSG00000140022|ensembl:ENST00000614646|ensembl:ENSP00000477736|interpro:IPR028565|refseq:NP_149095.2|interpro:IPR012320(Stonin homology)|interpro:IPR022699|interpro:IPR036168|interpro:IPR031228|refseq:NP_001243359.1|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043005"(neuron projection)|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048488"(synaptic vesicle endocytosis)|rcsb pdb:2JXC|mint:Q8WXE9	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AtPNlh4TC/kL9DnGQJqv1BVwQCM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62244	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347895|ensembl:ENSP00000318646|ensembl:ENSP00000457000|ensembl:ENSP00000458115|ensembl:ENSP00000458528|uniprotkb:P39027|uniprotkb:P39031|uniprotkb:Q3MHD9|uniprotkb:Q8C023|uniprotkb:Q9BV24	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs15a_human(display_long)|uniprotkb:RPS15A(gene name)|psi-mi:RPS15A(display_short)|uniprotkb:Small ribosomal subunit protein uS8(gene name synonym)|uniprotkb:OK/SW-cl.82(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134419(gene)|ensembl:ENST00000322989(transcript)|ensembl:ENST00000563390(transcript)|ensembl:ENST00000565420(transcript)|ensembl:ENST00000572008(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045787"(positive regulation of cell cycle)|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6G4W|interpro:IPR000630(Ribosomal protein S8)|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|interpro:IPR035987|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|mint:P62244|rcsb pdb:4UG0|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:4V6X|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-72695|reactome:R-HSA-975957|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZM7|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|refseq:NP_001010.2|refseq:NP_001025180.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Qdnhk7yvoFFYcRq5kEi7GQILaxs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00541	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053271|uniprotkb:Q6IC29|ensembl:ENSP00000346725	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pesc_human(display_long)|uniprotkb:PES1(gene name)|psi-mi:PES1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001230154.1|refseq:NP_055118.1|ensembl:ENSG00000100029(gene)|ensembl:ENST00000354694(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000466"("maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|interpro:IPR001357(BRCT)|interpro:IPR010613(Pescadillo, N-terminal)|interpro:IPR036420|rcsb pdb:2EP8|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Nq1SJ37kJfe+vF9zmNASz1gnbfY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8TEM1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372826|uniprotkb:A6NN56|uniprotkb:O94980|uniprotkb:Q6NXG6|uniprotkb:Q8NBJ1|uniprotkb:Q9H6C8|uniprotkb:Q9UFP3|ensembl:ENSP00000254508	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:po210_human(display_long)|uniprotkb:KIAA0906(gene name synonym)|uniprotkb:NUP210(gene name)|psi-mi:NUP210(display_short)|uniprotkb:PSEC0245(orf name)|uniprotkb:Nuclear envelope pore membrane protein POM 210(gene name synonym)|uniprotkb:Pore membrane protein of 210 kDa(gene name synonym)|uniprotkb:Nucleoporin Nup210(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-9610379|refseq:NP_079199.2|ensembl:ENSG00000132182(gene)|ensembl:ENST00000254508(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003343(Bacterial Ig-like, group 2)|interpro:IPR008964(Invasin/intimin cell-adhesion)|mint:Q8TEM1|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:udIemFThWYk0VC21Ml4EDDQWXlg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14103	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299674|ensembl:ENSP00000313199|uniprotkb:P07029|uniprotkb:Q01858|uniprotkb:Q14100|uniprotkb:Q14101|uniprotkb:Q14102|uniprotkb:Q4W5A1|uniprotkb:A8K9J2|uniprotkb:Q9UCE8|uniprotkb:Q9UCE9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpd_human(display_long)|uniprotkb:HNRNPD(gene name)|psi-mi:HNRNPD(display_short)|uniprotkb:AUF1(gene name synonym)|uniprotkb:HNRPD(gene name synonym)|uniprotkb:AU-rich element RNA-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000138668(gene)|ensembl:ENST00000313899(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1901355"(response to rapamycin)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1904586"(cellular response to putrescine)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990828"(hepatocyte dedifferentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR035979|mint:Q14103|rcsb pdb:1HD0|rcsb pdb:1HD1|rcsb pdb:1IQT|rcsb pdb:1WTB|rcsb pdb:1X0F|rcsb pdb:2Z5N|rcsb pdb:5IM0|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|reactome:R-HSA-450408|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:NP_001003810.1|refseq:NP_002129.2|refseq:NP_112737.1|refseq:NP_112738.1|dip:DIP-31163N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LrC0nOpN6jGn3WELs5NEOccNPnw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07814	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N163	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09211	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353467|uniprotkb:O00460|uniprotkb:Q15690|ensembl:ENSP00000381607|uniprotkb:Q5TZY3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstp1_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short)|uniprotkb:GST3(gene name synonym)|uniprotkb:FAEES3(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:GSTP1-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000843.1|ensembl:ENSG00000084207(gene)|go:"GO:0000302"(response to reactive oxygen species)|ensembl:ENST00000398606(transcript)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0035732"(nitric oxide storage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P09211|rcsb pdb:10GS|rcsb pdb:11GS|rcsb pdb:12GS|rcsb pdb:13GS|rcsb pdb:14GS|rcsb pdb:16GS|rcsb pdb:17GS|rcsb pdb:18GS|rcsb pdb:19GS|rcsb pdb:1AQV|rcsb pdb:1AQW|rcsb pdb:1AQX|rcsb pdb:1EOG|rcsb pdb:1EOH|rcsb pdb:1GSS|rcsb pdb:1KBN|rcsb pdb:1LBK|rcsb pdb:1MD3|rcsb pdb:1MD4|rcsb pdb:1PGT|rcsb pdb:1PX6|rcsb pdb:1PX7|rcsb pdb:1ZGN|rcsb pdb:20GS|rcsb pdb:22GS|rcsb pdb:2A2R|rcsb pdb:2A2S|rcsb pdb:2GSS|rcsb pdb:2J9H|rcsb pdb:2PGT|rcsb pdb:3CSH|rcsb pdb:3CSI|rcsb pdb:3CSJ|rcsb pdb:3DD3|rcsb pdb:3DGQ|rcsb pdb:3GSS|rcsb pdb:3GUS|rcsb pdb:3HJM|rcsb pdb:3HJO|rcsb pdb:3HKR|rcsb pdb:3IE3|rcsb pdb:3KM6|rcsb pdb:3KMN|rcsb pdb:3KMO|rcsb pdb:3N9J|rcsb pdb:3PGT|rcsb pdb:4GSS|rcsb pdb:4PGT|rcsb pdb:5DAK|rcsb pdb:5DAL|rcsb pdb:5DCG|rcsb pdb:5DDL|rcsb pdb:5DJL|rcsb pdb:5DJM|rcsb pdb:5GSS|rcsb pdb:5J41|rcsb pdb:5JCW|rcsb pdb:5L6X|rcsb pdb:5X79|rcsb pdb:6AP9|rcsb pdb:6GSS|rcsb pdb:6LLX|rcsb pdb:6Y1E|rcsb pdb:7GSS|rcsb pdb:8GSS|rcsb pdb:9GSS|reactome:R-HSA-156590|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxqbNusNIvkTg3Cq+7pmygP/EIA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35268	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354533|intact:EBI-1055963|uniprotkb:Q6IBD1|uniprotkb:B2R495|ensembl:ENSP00000346088	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl22_human(display_long)|uniprotkb:RPL22(gene name)|psi-mi:RPL22(display_short)|uniprotkb:Heparin-binding protein HBp15(gene name synonym)|uniprotkb:Epstein-Barr virus small RNA-associated protein(gene name synonym)|uniprotkb:EBER-associated protein(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL22(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000974.1|ensembl:ENSG00000116251(gene)|ensembl:ENST00000234875(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008201"(heparin binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045182"(translation regulator activity)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002671(Ribosomal protein L22e)|interpro:IPR038526|mint:P35268|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|reactome:R-HSA-72706|rcsb pdb:6Z6L|rcsb pdb:6Z6M|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0TVillnqDkHmdTwxIedAJCVAdzY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WWM7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-948363|ensembl:ENSP00000338718|uniprotkb:O95135|uniprotkb:Q6NVJ8|uniprotkb:Q6PJW6|uniprotkb:Q8IU61|uniprotkb:Q8IU95|uniprotkb:Q8WWM3|uniprotkb:Q8WWM4|uniprotkb:Q8WWM5|uniprotkb:Q8WWM6|uniprotkb:Q99703|uniprotkb:B9EGM2|uniprotkb:E9PAR9|uniprotkb:A8K1R6|uniprotkb:Q63ZY4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atx2l_human(display_long)|uniprotkb:Ataxin-2 domain protein(gene name synonym)|uniprotkb:Ataxin-2-related protein(gene name synonym)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)|uniprotkb:A2D(gene name synonym)|uniprotkb:A2LG(gene name synonym)|uniprotkb:A2LP(gene name synonym)|uniprotkb:A2RP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000168488(gene)|ensembl:ENST00000336783(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045296"(cadherin binding)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q8WWM7|refseq:NP_009176.2|refseq:NP_663760.1|refseq:NP_680780.1|refseq:NP_680781.1|refseq:XP_005255123.1|refseq:NP_059867.3|refseq:NP_680782.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:t7lrS10IM/5pt+rrbqBRowZ6b+09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14152	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NZM3-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190150|ensembl:ENSP00000354561	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q9nzm3-2(display_long)|uniprotkb:ITSN2(gene name)|psi-mi:ITSN2(display_short)|uniprotkb:KIAA1256(gene name synonym)|uniprotkb:SH3D1B(gene name synonym)|uniprotkb:SWAP(gene name synonym)|uniprotkb:SH3 domain-containing protein 1B(gene name synonym)|uniprotkb:SH3P18(gene name synonym)|uniprotkb:SH3P18-like WASP-associated protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198399(gene)|ensembl:ENST00000361999(transcript)|intact:EBI-308689(isoform-parent)|uniprotkb:Q9NZM3-2(isoform-parent)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WTz75JabFgL3LVJ2FJZk81RTmfY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:C9JNW5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190023|ensembl:ENSP00000420380	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c9jnw5_human(display_long)|uniprotkb:RPL24(gene name)|psi-mi:RPL24(display_short)|uniprotkb:hCG_2023003(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114391(gene)|ensembl:ENST00000469605(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|interpro:IPR000988(Ribosomal protein L24e)|interpro:IPR011017(TRASH)|interpro:IPR023442|interpro:IPR038630	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OE53tm5RMpxZtGwHcVKogk9J89A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-744603|uniprotkb:Q14818|uniprotkb:Q14819|uniprotkb:Q15913|uniprotkb:Q8IY00|uniprotkb:Q92744|uniprotkb:Q92745|uniprotkb:Q969H7|uniprotkb:Q9BW01|uniprotkb:Q9UEI0|uniprotkb:B7Z1Q1|uniprotkb:C9JJE2|ensembl:ENSP00000366607	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf01_human(display_long)|uniprotkb:Zinc finger protein 162(gene name synonym)|uniprotkb:Transcription factor ZFM1(gene name synonym)|uniprotkb:Zinc finger gene in MEN1 locus(gene name synonym)|uniprotkb:Mammalian branch point-binding protein(gene name synonym)|uniprotkb:SF1(gene name)|psi-mi:SF1(display_short)|uniprotkb:ZFM1(gene name synonym)|uniprotkb:ZNF162(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001171501.1|refseq:NP_001171502.1|refseq:NP_004621.2|refseq:NP_973724.1|refseq:NP_973727.1|rcsb pdb:4FXX|rcsb pdb:4FXW|reactome:R-HSA-72163|refseq:XP_016873733.1|ensembl:ENSG00000168066(gene)|ensembl:ENST00000377390(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005840"(ribosome)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030238"(male sex determination)|go:"GO:0030575"(nuclear body organization)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045131"(pre-mRNA branch point binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR031150|interpro:IPR032570|interpro:IPR036612|mint:Q15637|rcsb pdb:1K1G|rcsb pdb:1O0P|rcsb pdb:1OPI|rcsb pdb:2M09|rcsb pdb:2M0G|refseq:NP_001333292.1|refseq:NP_001333293.1|dip:DIP-29410N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N4k5Rvc5EDsSJt50J4ojje9p0249606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02878	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359655|uniprotkb:Q2M3Q3|uniprotkb:Q8WW97|ensembl:ENSP00000202773|ensembl:ENSP00000403172	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl6_human(display_long)|uniprotkb:RPL6(gene name)|psi-mi:RPL6(display_short)|uniprotkb:TXREB1(gene name synonym)|uniprotkb:Tax-responsive enhancer element-binding protein 107(gene name synonym)|uniprotkb:Neoplasm-related protein C140(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000961.2|refseq:NP_001019833.1|ensembl:ENSG00000089009(gene)|ensembl:ENST00000202773(transcript)|ensembl:ENST00000424576(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR000915(Ribosomal protein L6E)|interpro:IPR005568(Ribosomal protein L6, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041997|mint:Q02878|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001307066.1|refseq:NP_001307067.1|refseq:NP_001307068.1|refseq:NP_001307069.1|refseq:NP_001307070.1|refseq:XP_016875270.1|refseq:XP_016875271.1|dip:DIP-27547N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y7fx3ToInzucV2QmI8KLSdHxai09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q04637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24534	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354334|uniprotkb:Q6IBH9|uniprotkb:A8K795|ensembl:ENSP00000236957|ensembl:ENSP00000376055|ensembl:ENSP00000376056|ensembl:ENSP00000489993|ensembl:ENSP00000490214|ensembl:ENSP00000490326	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1b_human(display_long)|uniprotkb:EEF1B(gene name synonym)|uniprotkb:EF1B(gene name synonym)|uniprotkb:EEF1B2(gene name)|psi-mi:EEF1B2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032752.1|refseq:NP_001950.1|refseq:NP_066944.1|ensembl:ENSG00000114942(gene)|ensembl:ENSG00000283391(gene)|ensembl:ENST00000236957(transcript)|ensembl:ENST00000392221(transcript)|ensembl:ENST00000392222(transcript)|ensembl:ENST00000635728(transcript)|ensembl:ENST00000636275(transcript)|ensembl:ENST00000637253(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0045471"(response to ethanol)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219|interpro:IPR036282|mint:P24534|rcsb pdb:1B64|rcsb pdb:5DQS|reactome:R-HSA-156842	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:d4zkwQOMlpr6XBapMfT1sxy2ZPs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049228|uniprotkb:P78493|uniprotkb:P78494|uniprotkb:Q15364|uniprotkb:Q15686|uniprotkb:Q15687|uniprotkb:Q15689|uniprotkb:Q99377|uniprotkb:Q9UE45|uniprotkb:Q9UE46|uniprotkb:Q9UE47|uniprotkb:Q9UE48|uniprotkb:Q9UFQ6|intact:EBI-3190943|uniprotkb:B3KUA3|ensembl:ENSP00000472998	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ru17_human(display_long)|uniprotkb:SNRNP70(gene name)|psi-mi:SNRNP70(display_short)|uniprotkb:RPU1(gene name synonym)|uniprotkb:U1AP1(gene name synonym)|uniprotkb:RNPU1Z(gene name synonym)|uniprotkb:SNRP70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003080.2|refseq:NP_001287998.1|ensembl:ENSG00000104852(gene)|ensembl:ENST00000598441(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005685"(U1 snRNP)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR022023|interpro:IPR034143|interpro:IPR035979|mint:P08621|rcsb pdb:2L5I|rcsb pdb:2L5J|rcsb pdb:3CW1|rcsb pdb:3PGW|rcsb pdb:4PJO|rcsb pdb:4PKD|rcsb pdb:6QX9|rcsb pdb:7B0Y|reactome:R-HSA-72163|dip:DIP-29406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/P72B69q5f0TX4vTr4GuRrtgiRM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B7Z5V2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190263	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b7z5v2_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0042995"(cell projection)|interpro:IPR019749|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019747|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018980|interpro:IPR008954(Moesin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+vK2a20sO9KEUDpPbszDHGxJpOA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16698	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2554876|uniprotkb:B7Z6B8|uniprotkb:Q93085|uniprotkb:Q2M304|ensembl:ENSP00000220764|intact:EBI-10969978	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:decr_human(display_long)|uniprotkb:DECR(gene name synonym)|uniprotkb:2,4-dienoyl-CoA reductase [NADPH](gene name synonym)|uniprotkb:DECR1(gene name)|psi-mi:DECR1(display_short)|uniprotkb:SDR18C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 18C member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001350.1|ensembl:ENSG00000104325(gene)|ensembl:ENST00000220764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008670"("2,4-dienoyl-CoA reductase (NADPH) activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0070402"(NADPH binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902494"(catalytic complex)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|mint:Q16698|rcsb pdb:1W6U|rcsb pdb:1W73|rcsb pdb:1W8D|reactome:R-HSA-77288|interpro:IPR036291|refseq:NP_001317504.1|refseq:XP_016868636.1|refseq:XP_016868637.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l/8jxdd4pqUIUV2eIThvXTd66yE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NR30	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357942|uniprotkb:Q13436|uniprotkb:Q5VX41|uniprotkb:Q68D35|uniprotkb:B2RDL0|intact:EBI-2555822|ensembl:ENSP00000346120	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx21_human(display_long)|uniprotkb:DDX21(gene name)|psi-mi:DDX21(display_short)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004719.2|dip:DIP-32941N|refseq:NP_001243839.1|ensembl:ENSG00000165732(gene)|ensembl:ENST00000354185(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9NR30|rcsb pdb:2M3D|rcsb pdb:6L5L|rcsb pdb:6L5M|rcsb pdb:6L5N|rcsb pdb:6L5O|reactome:R-HSA-5250924|reactome:R-HSA-6791226|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NSmxvs3DBWvKpVDEAHIpqy7/b6w9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050760|uniprotkb:Q53RW7|uniprotkb:Q6URK5|uniprotkb:D3DPF4|ensembl:ENSP00000376309|ensembl:ENSP00000416340|ensembl:ENSP00000503593|ensembl:ENSP00000504135|ensembl:ENSP00000504152	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa3_human(display_long)|uniprotkb:HNRPA3(gene name synonym)|uniprotkb:HNRNPA3(gene name)|psi-mi:HNRNPA3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_919223.1|refseq:NP_001317178.1|ensembl:ENSG00000170144(gene)|ensembl:ENST00000392524(transcript)|ensembl:ENST00000435711(transcript)|ensembl:ENST00000676629(transcript)|ensembl:ENST00000678111(transcript)|ensembl:ENST00000679159(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0051028"(mRNA transport)|go:"GO:0051033"(RNA transmembrane transporter activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034513|interpro:IPR034516|interpro:IPR035979|mint:P51991|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bbg0nIdhEHomcwtgZhT2yHy7+nU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14160	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357345|uniprotkb:Q6P496|uniprotkb:Q7Z5D1|uniprotkb:Q8WWV8|uniprotkb:Q96C69|uniprotkb:Q96GG1|ensembl:ENSP00000322938|ensembl:ENSP00000349486|ensembl:ENSP00000366756	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:scrib_human(display_long)|uniprotkb:SCRIB(gene name)|psi-mi:SCRIB(display_short)|uniprotkb:CRIB1(gene name synonym)|uniprotkb:KIAA0147(gene name synonym)|uniprotkb:LAP4(gene name synonym)|uniprotkb:SCRB1(gene name synonym)|uniprotkb:VARTUL(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056171.3|refseq:NP_874365.3|dip:DIP-31259N|ensembl:ENSG00000180900(gene)|ensembl:ENST00000320476(transcript)|ensembl:ENST00000356994(transcript)|ensembl:ENST00000377533(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q14160|rcsb pdb:1UJU|rcsb pdb:1WHA|rcsb pdb:1X5Q|rcsb pdb:2W4F|rcsb pdb:4WYT|rcsb pdb:4WYU|rcsb pdb:5VWC|rcsb pdb:5VWI|rcsb pdb:5VWK|rcsb pdb:6EEY|rcsb pdb:6ESP|rcsb pdb:6MS1|rcsb pdb:6MTU|rcsb pdb:6MTV|rcsb pdb:6MYE|rcsb pdb:6MYF|rcsb pdb:6XA6|rcsb pdb:6XA7|rcsb pdb:6XA8|rcsb pdb:7JO7|reactome:R-HSA-4608870|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y4lIQ2NivmndHYd/JXSKvU2jv+w9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y2Q3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053767|uniprotkb:Q7Z520|uniprotkb:Q6P4H0|uniprotkb:Q9P1S4|uniprotkb:B4DIH1|uniprotkb:B4DSY2|ensembl:ENSP00000351181	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstk1_human(display_long)|uniprotkb:Glutathione S-transferase subunit 13(gene name synonym)|uniprotkb:GST 13-13(gene name synonym)|uniprotkb:GST class-kappa(gene name synonym)|uniprotkb:GSTK1-1(gene name synonym)|uniprotkb:GSTK1(gene name)|psi-mi:GSTK1(display_short)|uniprotkb:HDCMD47P(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001137151.1|refseq:NP_001137152.1|refseq:NP_001137153.1|refseq:NP_057001.1|ensembl:ENSG00000197448(gene)|ensembl:ENST00000358406(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001853(DSBA oxidoreductase)|interpro:IPR014440(HCCA isomerase/glutathione S-transferase kappa)|interpro:IPR036249|interpro:IPR044088|rcsb pdb:1YZX|rcsb pdb:3RPN|rcsb pdb:3RPP|reactome:R-HSA-156590|reactome:R-HSA-9033241|dip:DIP-46924N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aTjqqss32Y4bcsXg6gYlazahVCw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6I3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713198|intact:EBI-28967658|ensembl:ENSP00000270460|uniprotkb:Q86ST3|uniprotkb:Q9HA18	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:epn1_human(display_long)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:EH domain-binding mitotic phosphoprotein(gene name synonym)|uniprotkb:EPN1(gene name)|psi-mi:EPN1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048568"(embryonic organ development)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q9Y6I3|rcsb pdb:1INZ|rcsb pdb:1KYD|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000063245(gene)|ensembl:ENST00000270460(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|ensembl:ENST00000085079|ensembl:ENSP00000085079|ensembl:ENSP00000270460|ensembl:ENST00000411543|ensembl:ENSP00000406209|refseq:NP_001123543.1|refseq:NP_001123544.1|refseq:NP_037465.2|refseq:XP_005258886.1|refseq:XP_016882211.1|refseq:XP_011525183.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mp6MIJYGUJryy3Lk5coFqvOt55c9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13526	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P67809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63104	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11387	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876302|ensembl:ENSP00000354522|uniprotkb:Q15610|uniprotkb:Q5TFY3|uniprotkb:Q9UJN0|uniprotkb:O43256|uniprotkb:Q12855|uniprotkb:Q12856|uniprotkb:A8KA78|uniprotkb:E1P5W3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:top1_human(display_long)|uniprotkb:DNA topoisomerase I(gene name synonym)|uniprotkb:TOP1(gene name)|psi-mi:TOP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198900(gene)|ensembl:ENST00000361337(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0012501"(programmed cell death)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|refseq:NP_003277.1|dip:DIP-36356N|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202|mint:P11387|rcsb pdb:1A31|rcsb pdb:1A35|rcsb pdb:1A36|rcsb pdb:1EJ9|rcsb pdb:1K4S|rcsb pdb:1K4T|rcsb pdb:1LPQ|rcsb pdb:1NH3|rcsb pdb:1R49|rcsb pdb:1RR8|rcsb pdb:1RRJ|rcsb pdb:1SC7|rcsb pdb:1SEU|rcsb pdb:1T8I|rcsb pdb:1TL8|reactome:R-HSA-4615885	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kB+3PVybgNp2mtOmDa7x8sygFuU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07910	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357966|uniprotkb:P22628|uniprotkb:Q53EX2|uniprotkb:Q59FD3|uniprotkb:Q5FWE8|uniprotkb:Q86SF8|uniprotkb:Q86U45|uniprotkb:Q96HK7|uniprotkb:Q96HM4|uniprotkb:Q96IY5|uniprotkb:Q9BTS3|uniprotkb:D3DS19|uniprotkb:D3DS22|intact:EBI-28976506|ensembl:ENSP00000404848|ensembl:ENSP00000451291|ensembl:ENSP00000452276	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpc_human(display_long)|uniprotkb:HNRNPC(gene name)|psi-mi:HNRNPC(display_short)|uniprotkb:HNRPC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070910.1|refseq:NP_001070911.1|refseq:NP_004491.2|refseq:NP_112604.2|ensembl:ENSP00000404848|ensembl:ENST00000430246|ensembl:ENSP00000442816|ensembl:ENST00000553300|ensembl:ENSP00000450544|ensembl:ENSP00000451291|ensembl:ENST00000554969|ensembl:ENSP00000452276|ensembl:ENSP00000450725|ensembl:ENST00000555883|ensembl:ENSP00000450629|ensembl:ENST00000556628|ensembl:ENSP00000451652|ensembl:ENST00000556897|ensembl:ENSP00000451176|refseq:XP_011535010.1|refseq:XP_011535011.1|refseq:XP_011535012.1|refseq:XP_011535013.1|refseq:XP_011535014.1|refseq:XP_016876741.1|refseq:XP_016876742.1|dip:DIP-29854N|refseq:XP_006720188.1|ensembl:ENSG00000092199(gene)|ensembl:ENST00000420743(transcript)|ensembl:ENST00000554455(transcript)|ensembl:ENST00000557201(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR035979|mint:P07910|rcsb pdb:1TXP|rcsb pdb:1WF2|rcsb pdb:2MXY|rcsb pdb:2MZ1|rcsb pdb:3LN4|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Fj5tiH0wrNUjTnsURIg8dB8laMg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27105	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38919	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299104|ensembl:ENSP00000497641|ensembl:ENSP00000497661|uniprotkb:Q15033|uniprotkb:Q96A18|uniprotkb:Q6IBQ2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4a3_human(display_long)|uniprotkb:KIAA0111(gene name synonym)|uniprotkb:EIF4A3(gene name)|psi-mi:EIF4A3(display_short)|uniprotkb:DDX48(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4A isoform 3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DDX48(gene name synonym)|uniprotkb:DEAD box protein 48(gene name synonym)|uniprotkb:Eukaryotic initiation factor 4A-like NUK-34(gene name synonym)|uniprotkb:Nuclear matrix protein 265(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072715"(cellular response to selenite ion)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904570"(negative regulation of selenocysteine incorporation)|go:"GO:1904574"(negative regulation of selenocysteine insertion sequence binding)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P38919|rcsb pdb:2HXY|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:4C9B|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6YVH|rcsb pdb:7A5P|reactome:R-HSA-1169408|reactome:R-HSA-159236|reactome:R-HSA-429947|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|ensembl:ENST00000647795(transcript)|ensembl:ENST00000649764(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|ensembl:ENSG00000141543(gene)|refseq:NP_055555.1|dip:DIP-33218N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8e6e4HlM1GsYqqgXyJ9XgzxLzls9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99661	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642317|uniprotkb:Q96C18|uniprotkb:Q96HB8|uniprotkb:Q9BWV8|uniprotkb:Q5JR88|uniprotkb:B3ITR9|uniprotkb:Q6ICU1|ensembl:ENSP00000361298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kif2c_human(display_long)|uniprotkb:KNSL6(gene name synonym)|uniprotkb:KIF2C(gene name)|psi-mi:KIF2C(display_short)|uniprotkb:Mitotic centromere-associated kinesin(gene name synonym)|uniprotkb:Kinesin-like protein 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006836.2|refseq:NP_001284584.1|refseq:NP_001284585.1|refseq:NP_001284586.1|ensembl:ENSG00000142945(gene)|ensembl:ENST00000372224(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q99661|rcsb pdb:2HEH|rcsb pdb:4UBF|rcsb pdb:4Y05|rcsb pdb:5MIO|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XKQr6i+9Xtdfir6V1C8PByAIg1c9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23246	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17844	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61978	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-304185|intact:EBI-28971491|ensembl:ENSP00000317788|ensembl:ENSP00000353552|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q59F98|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62|uniprotkb:Q5T6W4|intact:EBI-3440248|uniprotkb:Q6IBN1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpk_human(display_long)|uniprotkb:HNRNPK(gene name)|psi-mi:HNRNPK(display_short)|uniprotkb:HNRPK(gene name synonym)|uniprotkb:Transformation up-regulated nuclear protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000165119(gene)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000351839(transcript)|ensembl:ENST00000360384(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0002102"(podosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006396"(RNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61978|rcsb pdb:1J5K|rcsb pdb:1KHM|rcsb pdb:1ZZI|rcsb pdb:1ZZJ|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9610379|rcsb pdb:1ZZK|refseq:NP_002131.2|refseq:NP_112552.1|refseq:NP_112553.1|ensembl:ENSP00000317788|ensembl:ENSP00000353552|ensembl:ENST00000376263|ensembl:ENSP00000365439|ensembl:ENST00000376281|ensembl:ENSP00000365458|refseq:NP_001305115.1|refseq:NP_001305116.1|refseq:NP_001305117.1|refseq:XP_016870157.1|refseq:XP_005252017.1|refseq:XP_005252020.1|refseq:XP_005252022.1|dip:DIP-31805N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08945	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353771|uniprotkb:Q5BJG8|ensembl:ENSP00000278412	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ssrp1_human(display_long)|uniprotkb:SSRP1(gene name)|psi-mi:SSRP1(display_short)|uniprotkb:FACT80(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SSRP1(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex 80 kDa subunit(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 80 kDa subunit(gene name synonym)|uniprotkb:Structure-specific recognition protein 1(gene name synonym)|uniprotkb:Recombination signal sequence recognition protein 1(gene name synonym)|uniprotkb:T160(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003137.1|ensembl:ENSG00000149136(gene)|ensembl:ENST00000278412(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035101"(FACT complex)|go:"GO:0042393"(histone binding)|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000969(Structure-specific recognition protein)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR024954|interpro:IPR035417|interpro:IPR036910|interpro:IPR038167|mint:Q08945|rcsb pdb:4IFS|rcsb pdb:5UMR|rcsb pdb:5UMS|rcsb pdb:5VWE|rcsb pdb:6L1E|rcsb pdb:6L1R|rcsb pdb:6L34|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|dip:DIP-169N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WmdGVZadHdcS6Nk9SI41xKm+OrU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61289	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99615	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3C6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2557649|uniprotkb:Q5TDC9|uniprotkb:O15001|ensembl:ENSP00000362803	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppil1_human(display_long)|uniprotkb:PPIL1(gene name)|psi-mi:PPIL1(display_short)|uniprotkb:Rotamase PPIL1(gene name synonym)|uniprotkb:CYPL1(gene name synonym)|uniprotkb:CGI-124(orf name)|uniprotkb:UNQ2425/PRO4984(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057143.1|ensembl:ENSG00000137168(gene)|ensembl:ENST00000373699(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|interpro:IPR044666|rcsb pdb:1XWN|rcsb pdb:2K7N|rcsb pdb:2X7K|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|reactome:R-HSA-72163|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4Wx4abxOz/ayhkwVy/JYzA3d+SE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01085	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2820828|uniprotkb:A8K3T0|uniprotkb:A8K4L9|ensembl:ENSP00000394902	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tiar_human(display_long)|uniprotkb:TIAL1(gene name)|psi-mi:TIAL1(display_short)|uniprotkb:TIA-1-related protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001029097.1|refseq:NP_003243.1|ensembl:ENSG00000151923(gene)|ensembl:ENST00000436547(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007281"(germ cell development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017145"(stem cell division)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034492|interpro:IPR034494|interpro:IPR034496|interpro:IPR035979|mint:Q01085|rcsb pdb:1X4G|rcsb pdb:2CQI|rcsb pdb:2DH7|reactome:R-HSA-6803529|dip:DIP-42425N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dKWzIWmR/JaCJwsOLUPG2Z1uhH89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62258	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43405	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54136	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355482|uniprotkb:Q9BWA1|uniprotkb:B2RBS9|uniprotkb:Q53GY4|intact:EBI-28985219|ensembl:ENSP00000231572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syrc_human(display_long)|uniprotkb:RARS1(gene name)|psi-mi:RARS1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:RARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002878.2|ensembl:ENSG00000113643(gene)|ensembl:ENST00000231572(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:P54136|rcsb pdb:4Q2T|rcsb pdb:4Q2X|rcsb pdb:4Q2Y|rcsb pdb:4R3Z|rcsb pdb:4ZAJ|reactome:R-HSA-2408522|reactome:R-HSA-379716|ensembl:ENSP00000231572	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oM9gWF1NucjgVjBFm4DcjmnQNCE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43678	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bL66utte1nSuYj0nxg/BoktnXhs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27816	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715255|uniprotkb:Q59FT2|uniprotkb:Q68D74|uniprotkb:Q6ZUW9|uniprotkb:Q96NS9|uniprotkb:Q13082|uniprotkb:Q96A76|ensembl:ENSP00000353375|uniprotkb:Q86V26	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:map4_human(display_long)|uniprotkb:MAP4(gene name)|psi-mi:MAP4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001127836.1|refseq:NP_002366.2|ensembl:ENSG00000047849(gene)|ensembl:ENST00000360240(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR027323|mint:P27816|refseq:NP_112147.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rBf82W3kFCo+2UklK5WHO3MWjV09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62495	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750990|intact:EBI-1047744|uniprotkb:B2R6B4|uniprotkb:D3DQC1|uniprotkb:P46055|uniprotkb:Q5M7Z7|uniprotkb:Q96CG1|ensembl:ENSP00000353741	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:erf1_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)|uniprotkb:ERF1(gene name synonym)|uniprotkb:Protein Cl1(gene name synonym)|uniprotkb:RF1(gene name synonym)|uniprotkb:SUP45L1(gene name synonym)|uniprotkb:TB3-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004721.1|refseq:NP_001243231.1|refseq:NP_001278903.1|refseq:NP_001278904.1|refseq:XP_005271978.1|ensembl:ENSG00000120705(gene)|ensembl:ENST00000360541(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0043022"(ribosome binding)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|mint:P62495|rcsb pdb:1DT9|rcsb pdb:2HST|rcsb pdb:2KTU|rcsb pdb:2KTV|rcsb pdb:2LGT|rcsb pdb:2LLX|rcsb pdb:2MQ6|rcsb pdb:2MQ9|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3JAG|rcsb pdb:3JAH|rcsb pdb:3JAI|rcsb pdb:4D5N|rcsb pdb:4D61|rcsb pdb:5A8L|rcsb pdb:5LZT|rcsb pdb:5LZU|rcsb pdb:5LZV|rcsb pdb:6D90|rcsb pdb:6IP8|rcsb pdb:6XA1|rcsb pdb:6ZME|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31942	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711437|uniprotkb:Q9NPI4|uniprotkb:Q9UFU4|uniprotkb:Q9Y4J5|uniprotkb:Q9BSX1|uniprotkb:Q9NP53|uniprotkb:Q9NP96|uniprotkb:Q9NPA7|ensembl:ENSP00000265866|uniprotkb:A8K682|uniprotkb:B3KRE1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrh3_human(display_long)|uniprotkb:HNRNPH3(gene name)|psi-mi:HNRNPH3(display_short)|uniprotkb:HNRPH3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein 2H9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000096746(gene)|ensembl:ENST00000265866(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034969|interpro:IPR034970|interpro:IPR035979|mint:P31942|refseq:NP_036339.1|refseq:NP_067676.2|refseq:NP_001309363.1|refseq:NP_001309365.1|refseq:NP_001309366.1|refseq:NP_001309367.1|refseq:NP_001309368.1|refseq:NP_001309369.1|refseq:NP_001309370.1|refseq:NP_001309374.1|refseq:NP_001309375.1|refseq:NP_001309376.1|refseq:NP_001309377.1|refseq:NP_001309378.1|refseq:XP_016871657.1|refseq:XP_016871658.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iJGBIhPXnQIIFQmgxWB1WjwVXSY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49327	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356658|uniprotkb:Q4LE83|uniprotkb:Q13479|uniprotkb:Q16702|uniprotkb:Q6P4U5|uniprotkb:Q6SS02|uniprotkb:Q969R1|uniprotkb:Q96C68|uniprotkb:Q96IT0|ensembl:ENSP00000304592	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fas_human(display_long)|uniprotkb:FASN(gene name)|psi-mi:FASN(display_short)|uniprotkb:FAS(gene name synonym)|uniprotkb:Type I fatty acid synthase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004095.4|ensembl:ENSG00000169710(gene)|ensembl:ENST00000306749(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003723"(RNA binding)|go:"GO:0004313"([acyl-carrier-protein] S-acetyltransferase activity)|go:"GO:0004314"([acyl-carrier-protein] S-malonyltransferase activity)|go:"GO:0004315"(3-oxoacyl-[acyl-carrier-protein] synthase activity)|go:"GO:0004316"("3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity")|go:"GO:0004317"(3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0004320"(oleoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0008659"("(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity")|go:"GO:0008693"(3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0016020"(membrane)|go:"GO:0016295"(myristoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0016296"(palmitoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031177"(phosphopantetheine binding)|go:"GO:0042470"(melanosome)|go:"GO:0042587"(glycogen granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0047451"(3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0102131"(obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity)|go:"GO:0102132"(obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity)|interpro:IPR001031(Thioesterase)|interpro:IPR001227(Acyl transferase region)|interpro:IPR006162(Phosphopantetheine attachment site)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011032(GroES-like)|interpro:IPR013149(Alcohol dehydrogenase, zinc-binding)|interpro:IPR013217(Methyltransferase type 12)|interpro:IPR013968(Polyketide synthase, KR)|interpro:IPR014030(Beta-ketoacyl synthase, N-terminal)|interpro:IPR014031(Beta-ketoacyl synthase, C-terminal)|interpro:IPR014043(Acyl transferase)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR016036(Malonyl-CoA ACP transacylase, ACP-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR018201|interpro:IPR020806|interpro:IPR020807|interpro:IPR020841|interpro:IPR020843|interpro:IPR029058|interpro:IPR029063|interpro:IPR032821|interpro:IPR036291|interpro:IPR036736|interpro:IPR042104|mint:P49327|rcsb pdb:1XKT|rcsb pdb:2CG5|rcsb pdb:2JFD|rcsb pdb:2JFK|rcsb pdb:2PX6|rcsb pdb:3HHD|rcsb pdb:3TJM|rcsb pdb:4PIV|rcsb pdb:4W82|rcsb pdb:4W9N|rcsb pdb:4Z49|rcsb pdb:5C37|rcsb pdb:6NNA|reactome:R-HSA-163765|reactome:R-HSA-199220|reactome:R-HSA-2426168|reactome:R-HSA-75105|reactome:R-HSA-9029558|go:"GO:0047117"("enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity")|refseq:XP_011521840.1|dip:DIP-33681N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bQYEH/uQ6l+SPzLBDNCV5yP+yzs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92841	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746012|uniprotkb:Q69YT1|uniprotkb:Q6ICD6|uniprotkb:H3BLZ8|uniprotkb:B1AHM0|ensembl:ENSP00000385536	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx17_human(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:RNA-dependent helicase p72(gene name synonym)|uniprotkb:DEAD box protein p72(gene name synonym)|uniprotkb:DDX17(gene name)|psi-mi:DDX17(display_short)|uniprotkb:DEAD box protein p82(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006377.2|ensembl:ENSG00000100201(gene)|ensembl:ENST00000403230(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q92841|rcsb pdb:6UV0|rcsb pdb:6UV1|rcsb pdb:6UV2|rcsb pdb:6UV3|rcsb pdb:6UV4|reactome:R-HSA-3899300|dip:DIP-29843N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3UhUuhRSZg/zlM7UPDKYCqNmUho9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12770	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190187|ensembl:ENSP00000265565|ensembl:ENSP00000497087|uniprotkb:Q8N2E0|uniprotkb:Q8WUA1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:scap_human(display_long)|uniprotkb:SCAP(gene name)|psi-mi:SCAP(display_short)|uniprotkb:KIAA0199(gene name synonym)|uniprotkb:PSEC0227(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114650(gene)|ensembl:ENST00000648151(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032934"(sterol binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|ensembl:ENST00000265565(transcript)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030225|interpro:IPR036322|mint:Q12770|rcsb pdb:6M49|rcsb pdb:7ETW|reactome:R-HSA-1655829|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|refseq:XP_011531803.1|refseq:NP_036367.2|refseq:XP_016861407.1|refseq:XP_016861410.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bhavwLS6XzkZpAoBhCsII97JfpI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14697	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43447	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39656	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358866|uniprotkb:O43244|uniprotkb:Q8NI93|uniprotkb:Q9BUI2|uniprotkb:B2RDQ4|uniprotkb:Q5VWA5|ensembl:ENSP00000399457|uniprotkb:B4DJE3|uniprotkb:B4DLI2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ost48_human(display_long)|uniprotkb:DDOST(gene name)|psi-mi:DDOST(display_short)|uniprotkb:KIAA0115(gene name synonym)|uniprotkb:OST48(gene name synonym)|uniprotkb:OK/SW-cl.45(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005207.2|ensembl:ENSG00000244038(gene)|ensembl:ENST00000415136(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:P39656|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-9694548	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:utOlgvpqe2JHEJHk4gIp8tXwv/I9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15154	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WUM4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-310624|uniprotkb:Q9BX86|uniprotkb:Q9NUN0|uniprotkb:Q9P2H2|uniprotkb:Q9UKL5|uniprotkb:C5MQH7|intact:EBI-10971645|uniprotkb:E9PFU1|uniprotkb:Q6NUS1|ensembl:ENSP00000307387|intact:EBI-28983290	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdc6i_human(display_long)|uniprotkb:PDCD6IP(gene name)|psi-mi:PDCD6IP(display_short)|uniprotkb:AIP1(gene name synonym)|uniprotkb:KIAA1375(gene name synonym)|uniprotkb:ALIX(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:Hp95(gene name synonym)|uniprotkb:ALG-2-interacting protein X(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_037506.2|ensembl:ENSP00000307387|ensembl:ENST00000457054|ensembl:ENSP00000411825|refseq:NP_001155901.1|ensembl:ENSG00000170248(gene)|ensembl:ENST00000307296(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q8WUM4|rcsb pdb:2OEV|rcsb pdb:2OEW|rcsb pdb:2OEX|rcsb pdb:2OJQ|rcsb pdb:2R02|rcsb pdb:2R03|rcsb pdb:2R05|rcsb pdb:2XS1|rcsb pdb:2XS8|rcsb pdb:2ZNE|rcsb pdb:3C3O|rcsb pdb:3C3Q|rcsb pdb:3C3R|rcsb pdb:3E1R|rcsb pdb:3WUV|rcsb pdb:4JJY|rcsb pdb:5V3R|rcsb pdb:5WA1|rcsb pdb:6KP3|reactome:R-HSA-162588|reactome:R-HSA-5210891|reactome:R-HSA-5213460|reactome:R-HSA-5675482|refseq:NP_001243121.1|dip:DIP-29327N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FYD19EyMBAGl204Xlgr4MlE8GMs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63000	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15366	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945799|uniprotkb:Q6PKG5|intact:EBI-9640573|uniprotkb:Q6IPF4|uniprotkb:B4DXP5|intact:EBI-2555278|uniprotkb:A8K7X6|uniprotkb:F8VYL7|uniprotkb:Q32Q82|uniprotkb:Q68Y55|uniprotkb:I6L8F9|uniprotkb:Q59HD4|uniprotkb:G3V0E8|ensembl:ENSP00000408949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcbp2_human(display_long)|uniprotkb:PCBP2(gene name)|psi-mi:PCBP2(display_short)|uniprotkb:Alpha-CP2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001122383.1|refseq:NP_114366.1|refseq:NP_005007.2|refseq:NP_001092090.1|refseq:NP_001122384.1|refseq:NP_001122385.1|refseq:NP_001122386.1|dip:DIP-58934N|ensembl:ENSG00000197111(gene)|ensembl:ENST00000439930(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15366|rcsb pdb:2AXY|rcsb pdb:2JZX|rcsb pdb:2P2R|rcsb pdb:2PQU|rcsb pdb:2PY9|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-936440	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KWabGhH+pfSX5k0vzs3SXH8Agaw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42566	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-396684|uniprotkb:B2R8J7|uniprotkb:Q5SRH4|uniprotkb:D3DPJ2|intact:EBI-28966731|ensembl:ENSP00000360798	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eps15_human(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153441.1|refseq:NP_001972.1|ensembl:ENSP00000360798|ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P42566|rcsb pdb:1C07|rcsb pdb:1EH2|rcsb pdb:1F8H|rcsb pdb:1FF1|rcsb pdb:2IV9|rcsb pdb:2JXC|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4S0G|rcsb pdb:5AWT|rcsb pdb:5AWU|rcsb pdb:5JP2|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|dip:DIP-33064N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6PKG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13310	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372844|uniprotkb:Q6P0N3|uniprotkb:B1ANQ8|ensembl:ENSP00000361948|intact:EBI-877641|uniprotkb:Q4VC03	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pabp4_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:APP1(gene name synonym)|uniprotkb:PABP4(gene name synonym)|uniprotkb:"Inducible poly(A)-binding protein"(gene name synonym)|uniprotkb:Activated-platelet protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129126.1|refseq:NP_003810.1|ensembl:ENSG00000090621(gene)|ensembl:ENST00000372857(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006412"(translation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0061515"(myeloid cell development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q13310|refseq:NP_001129125.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u1qCM3o5X7jLIa1vyqFCIH7v01w9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32119	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1266300|uniprotkb:P31945|uniprotkb:P32118|uniprotkb:P35701|uniprotkb:Q6FHG4|uniprotkb:Q92763|uniprotkb:Q9UC23|uniprotkb:A8K0C0|ensembl:ENSP00000301522	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx2_human(display_long)|uniprotkb:PRDX2(gene name)|psi-mi:PRDX2(display_short)|uniprotkb:NKEFB(gene name synonym)|uniprotkb:TDPX1(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor B(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005800.3|dip:DIP-39882N|ensembl:ENSG00000167815(gene)|ensembl:ENST00000301522(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P32119|rcsb pdb:1QMV|rcsb pdb:5B8A|rcsb pdb:5B8B|rcsb pdb:5IJT|rcsb pdb:7KIZ|rcsb pdb:7KJ0|rcsb pdb:7KJ1|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:F8+7/3HrAcJq7BjkZaig16mCOO89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62937	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42356	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-723050|uniprotkb:Q7Z625|uniprotkb:Q9UPG2|ensembl:ENSP00000255882|intact:EBI-11053324	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pi4ka_human(display_long)|uniprotkb:PIK4CA(gene name synonym)|uniprotkb:PI4KA(gene name)|psi-mi:PI4KA(display_short)|uniprotkb:PIK4(gene name synonym)|uniprotkb:Phosphatidylinositol 4-Kinase III alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000241973(gene)|ensembl:ENST00000255882(transcript)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR042236|rcsb pdb:6BQ1|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016301"(kinase activity)|refseq:NP_477352.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tm7wwZPJEvFMfK9xHMPLW9oYtzk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00410	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UBC2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2556746|intact:EBI-28972990|ensembl:ENSP00000248070|uniprotkb:B4DKA3|uniprotkb:A2RRF3|uniprotkb:A5PL29	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ep15r_human(display_long)|uniprotkb:EPS15R(gene name synonym)|uniprotkb:Eps15-related protein(gene name synonym)|uniprotkb:EPS15L1(gene name)|psi-mi:EPS15L1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_067058.1|ensembl:ENSP00000248070|ensembl:ENST00000455140|ensembl:ENSP00000393313|ensembl:ENST00000535753|ensembl:ENSP00000440103|ensembl:ENST00000597937|ensembl:ENSP00000472267|ensembl:ENST00000602022|ensembl:ENSP00000471981|ensembl:ENSG00000127527(gene)|ensembl:ENST00000248070(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0045296"(cadherin binding)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q9UBC2|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0030132"(clathrin coat of coated pit)|refseq:NP_001245303.1|refseq:NP_001245304.1|refseq:NP_001245305.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6Bsao5czetxRxIiy3O/rZox4U+Y9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26599	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350540|ensembl:ENSP00000014112|intact:EBI-744534|uniprotkb:Q9BUQ0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptbp1_human(display_long)|uniprotkb:PTBP1(gene name)|psi-mi:PTBP1(display_short)|uniprotkb:PTB(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein I(gene name synonym)|uniprotkb:57 kDa RNA-binding protein PPTB-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002810.1|refseq:NP_114367.1|refseq:NP_114368.1|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0016020"(membrane)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034798|interpro:IPR035000|interpro:IPR035001|interpro:IPR035979|mint:P26599|rcsb pdb:1QM9|rcsb pdb:1SJQ|ensembl:ENSG00000011304(gene)|ensembl:ENST00000349038(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0008380"(RNA splicing)|rcsb pdb:2AD9|rcsb pdb:2ADB|rcsb pdb:2ADC|rcsb pdb:2EVZ|rcsb pdb:2N3O|rcsb pdb:3ZZY|rcsb pdb:3ZZZ|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|rcsb pdb:1SJR	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fkSnYJELgHxDP0oAQEjBmSX0HIs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54886	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1210304|ensembl:ENSP00000360268|uniprotkb:O95952|uniprotkb:Q5T566|uniprotkb:Q9UM72|uniprotkb:Q3KQU2|uniprotkb:B2R5Q4|uniprotkb:B7Z350|uniprotkb:B7Z5X8|uniprotkb:B7ZLP1|uniprotkb:Q5T567|uniprotkb:D3DR44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p5cs_human(display_long)|uniprotkb:ALDH18A1(gene name)|psi-mi:ALDH18A1(display_short)|uniprotkb:P5CS(gene name synonym)|uniprotkb:PYCS(gene name synonym)|uniprotkb:GSAS(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 18 member A1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000059573(gene)|ensembl:ENST00000371224(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004349"(glutamate 5-kinase activity)|go:"GO:0004350"(glutamate-5-semialdehyde dehydrogenase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0006592"(ornithine biosynthetic process)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000965(Gamma-glutamyl phosphate reductase GPR)|interpro:IPR001048(Aspartate/glutamate/uridylate kinase)|refseq:NP_001017423.1|refseq:NP_002851.2|refseq:NP_001310341.1|refseq:NP_001310342.1|refseq:NP_001310343.1|refseq:NP_001310344.1|refseq:NP_001310345.1|refseq:NP_001310348.1|interpro:IPR001057(Glutamate 5-kinase)|interpro:IPR005715(Glutamate 5-kinase, ProB-related)|interpro:IPR005766(delta l-pyrroline-5-carboxylate synthetase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR019797|interpro:IPR020593|interpro:IPR036393|interpro:IPR041744|mint:P54886|rcsb pdb:2H5G|reactome:R-HSA-8964539	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NLYlqQhi3HebSXYBxkkSmKplRCM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22626	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299649|ensembl:ENSP00000346694|ensembl:ENSP00000349101|ensembl:ENSP00000354021|ensembl:ENSP00000503360|ensembl:ENSP00000503476|ensembl:ENSP00000503514|ensembl:ENSP00000503885|ensembl:ENSP00000504329|uniprotkb:P22627|uniprotkb:A8K064|uniprotkb:Q9UC98|uniprotkb:Q9UDJ2|uniprotkb:A0A024RA27|uniprotkb:A0A024RA61	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa2_human(display_long)|uniprotkb:HNRNPA2B1(gene name)|psi-mi:HNRNPA2B1(display_short)|uniprotkb:HNRPA2B1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|ensembl:ENST00000679001(transcript)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0050658"(RNA transport)|ensembl:ENST00000679021(transcript)|go:"GO:0070062"(extracellular exosome)|ensembl:ENST00000679123(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:1990428"(miRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034486|interpro:IPR034489|interpro:IPR035979|mint:P22626|rcsb pdb:1X4B|rcsb pdb:5EN1|rcsb pdb:5HO4|rcsb pdb:5WWE|rcsb pdb:5WWF|rcsb pdb:5WWG|rcsb pdb:6WPQ|rcsb pdb:6WQK|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|ensembl:ENSG00000122566(gene)|ensembl:ENST00000354667(transcript)|ensembl:ENST00000356674(transcript)|ensembl:ENST00000360787(transcript)|ensembl:ENST00000676746(transcript)|ensembl:ENST00000678675(transcript)|refseq:NP_002128.1|refseq:NP_112533.1|dip:DIP-32877N|refseq:XP_005249786.1|refseq:XP_016867598.1|refseq:XP_016867599.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N2NeJVio9eYQULNcdE1KXtd2KPw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60506	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1024357|uniprotkb:Q53H05|uniprotkb:Q5TCG2|uniprotkb:Q8IW78|uniprotkb:Q8N599|uniprotkb:Q96LC1|uniprotkb:Q96LC2|uniprotkb:Q9Y583|uniprotkb:Q5TCG3|uniprotkb:E1P501|uniprotkb:E1P502|ensembl:ENSP00000358635|ensembl:ENSP00000503783|ensembl:ENSP00000504706	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpq_human(display_long)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:SYNCRIP(gene name)|psi-mi:SYNCRIP(display_short)|uniprotkb:HNRPQ(gene name synonym)|uniprotkb:NSAP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153145.1|refseq:NP_001153146.1|refseq:NP_001153147.1|refseq:NP_001240700.1|refseq:NP_001153148.1|refseq:NP_001153149.1|refseq:NP_006363.4|ensembl:ENSG00000135316(gene)|ensembl:ENST00000369622(transcript)|ensembl:ENST00000676688(transcript)|ensembl:ENST00000678355(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:O60506|rcsb pdb:2DGU|rcsb pdb:2MXT|rcsb pdb:2NBB|rcsb pdb:6KOR|refseq:XP_016865667.1|refseq:XP_005248694.1|dip:DIP-35540N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2rDkXIp/wWzTOoVtN7Bd3uqZo689606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11940	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XudTSPq2h9ckKAc48X88RVafPRU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7RTV0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2555365|uniprotkb:Q9UH06|ensembl:ENSP00000216252	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phf5a_human(display_long)|uniprotkb:Splicing factor 3B-associated 14 kDa protein(gene name synonym)|uniprotkb:PHF5A(gene name)|psi-mi:PHF5A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_116147.1|ensembl:ENSG00000100410(gene)|ensembl:ENST00000216252(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR005345(PHF5-like)|mint:Q7RTV0|rcsb pdb:5IFE|rcsb pdb:5O9Z|rcsb pdb:5SYB|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:5ZYA|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|go:"GO:0048863"(stem cell differentiation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TrngLk+KyJ+qRs8HGvH1LZH2Tsg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16181	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2009373|uniprotkb:Q52M76|uniprotkb:Q6NX50|ensembl:ENSP00000381992	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sept7_human(display_long)|uniprotkb:SEPTIN7(gene name)|psi-mi:SEPTIN7(display_short)|uniprotkb:CDC10(gene name synonym)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:SEPT7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001779.3|dip:DIP-47093N|ensembl:ENSG00000122545(gene)|ensembl:ENST00000399034(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR008115(Septin 7)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:2QAG|rcsb pdb:3T5D|rcsb pdb:3TW4|rcsb pdb:6N0B|rcsb pdb:6N12|rcsb pdb:6UQQ|reactome:R-HSA-5687128	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CweIjGLXC7eubvKR7vkkihEkcHg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21333	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62906	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356860|uniprotkb:P52859|uniprotkb:P53025|uniprotkb:Q5TZT6|uniprotkb:Q8J013|uniprotkb:B2R801|ensembl:ENSP00000363018	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl10a_human(display_long)|uniprotkb:RPL10A(gene name)|psi-mi:RPL10A(display_short)|uniprotkb:NEDD6(gene name synonym)|uniprotkb:CSA-19(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 6(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009035.3|ensembl:ENSG00000198755(gene)|ensembl:ENST00000322203(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673|interpro:IPR023674|interpro:IPR028364|mint:P62906|rcsb pdb:4UG0|rcsb pdb:4V6X|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LU8|rcsb pdb:6OLG|rcsb pdb:6QZP|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wrXKX6vzZ3ovXP3yUoL1/r+NGiw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99798	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2932893|ensembl:ENSP00000216254|uniprotkb:O75809|uniprotkb:Q5JZ41|uniprotkb:Q6FHX0|uniprotkb:Q8TAQ6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:acon_human(display_long)|uniprotkb:ACO2(gene name)|psi-mi:ACO2(display_short)|uniprotkb:Citrate hydro-lyase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100412(gene)|ensembl:ENST00000216254(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003994"(aconitate hydratase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0035900"(response to isolation stress)|go:"GO:0047780"(citrate dehydratase activity)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000573(Aconitase A/isopropylmalate dehydratase small subunit, swivel)|interpro:IPR001030(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha)|interpro:IPR006248(Aconitase, mitochondrial-like)|interpro:IPR015928(Aconitase/3-isopropylmalate dehydratase, swivel)|interpro:IPR015932(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2)|interpro:IPR018136|interpro:IPR036008|mint:Q99798|reactome:R-HSA-1268020|reactome:R-HSA-71403|interpro:IPR015931(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomains 1 and 3)|refseq:NP_001089.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QpDlGJHSwqfCktMlwYXKTonXftA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31943	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q06124	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13639	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352560|uniprotkb:Q58J86|uniprotkb:B2RMP5|uniprotkb:D6W618|ensembl:ENSP00000307940	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef2_human(display_long)|uniprotkb:EEF2(gene name)|psi-mi:EEF2(display_short)|uniprotkb:EF2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001952.1|ensembl:ENSG00000167658(gene)|ensembl:ENST00000309311(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P13639|rcsb pdb:4V6X|rcsb pdb:6D9J|rcsb pdb:6Z6M|rcsb pdb:6Z6N|reactome:R-HSA-156902|reactome:R-HSA-5336415|reactome:R-HSA-5358493|reactome:R-HSA-6798695|reactome:R-HSA-8876725	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:US1dzGQ5V1oBXVtYeGt5H3HCIr09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62899	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053664|intact:EBI-3867511|uniprotkb:B7Z4K2|uniprotkb:P12947|uniprotkb:Q53SQ5|uniprotkb:Q6LBJ6|uniprotkb:D3DVJ4|uniprotkb:Q6IRZ0|ensembl:ENSP00000264258|ensembl:ENSP00000386681	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl31_human(display_long)|uniprotkb:RPL31(gene name)|psi-mi:RPL31(display_short)|uniprotkb:Large ribosomal subunit protein eL31(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000984.1|refseq:NP_001092047.1|refseq:NP_001093163.1|ensembl:ENSG00000071082(gene)|ensembl:ENST00000264258(transcript)|ensembl:ENST00000409733(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|mint:P62899|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:77LFR7/2somk6blVogZf1XFdJLk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5SSJ5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2880687|ensembl:ENSP00000312625|ensembl:ENSP00000403039|uniprotkb:Q5SWC6|uniprotkb:Q6PIM9|uniprotkb:B3KMZ8|uniprotkb:A8K5D7|uniprotkb:Q8NDF0|uniprotkb:Q05BI0|uniprotkb:B4E210|uniprotkb:A6NI71|uniprotkb:Q9UHY0|uniprotkb:Q5SSJ6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hp1b3_human(display_long)|uniprotkb:HP1BP3(gene name)|psi-mi:HP1BP3(display_short)|uniprotkb:Protein HP1-BP74(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000127483(gene)|ensembl:ENST00000312239(transcript)|ensembl:ENST00000438032(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097298"(regulation of nucleus size)|interpro:IPR005818(Histone H1/H5)|interpro:IPR033061|interpro:IPR036388|interpro:IPR036390|mint:Q5SSJ5|rcsb pdb:2RQP|go:"GO:0005694"(chromosome)|refseq:XP_016856882.1|refseq:XP_016856883.1|refseq:XP_011539834.1|refseq:XP_011539835.1|refseq:XP_011539836.1|refseq:NP_057371.2|refseq:XP_005245932.1|refseq:XP_005245933.1|refseq:XP_005245934.1|refseq:XP_005245935.1|refseq:XP_005245936.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kLFithZZv+Qn9YLElEnX81awKDw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q1WWK5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190162	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q1wwk5_human(display_long)|uniprotkb:SEPT9(gene name)|psi-mi:SEPT9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005525"(GTP binding)|interpro:IPR027417|interpro:IPR030645	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:80HBLhdKw7dQlez8rvVWnMBquJM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02790	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30050	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352743|uniprotkb:Q6PB27|uniprotkb:Q5VVV2|ensembl:ENSP00000354739	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl12_human(display_long)|uniprotkb:RPL12(gene name)|psi-mi:RPL12(display_short)|uniprotkb:Large ribosomal subunit protein uL11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000967.1|ensembl:ENSG00000197958(gene)|ensembl:ENST00000361436(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P30050|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TNPEtl60cILofaPzUznvZiw6D7E9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54577	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048893|uniprotkb:O43276|uniprotkb:Q53EN1|uniprotkb:B3KWK4|uniprotkb:D3DPQ4|ensembl:ENSP00000362576	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syyc_human(display_long)|uniprotkb:YARS1(gene name)|psi-mi:YARS1(display_short)|uniprotkb:Tyrosyl-tRNA synthetase(gene name synonym)|uniprotkb:YARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003671.1|ensembl:ENSG00000134684(gene)|ensembl:ENST00000373477(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004831"(tyrosine-tRNA ligase activity)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006437"(tyrosyl-tRNA aminoacylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0016604"(nuclear body)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002307(Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial)|interpro:IPR002547(tRNA-binding region)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1N3L|rcsb pdb:1NTG|rcsb pdb:1Q11|rcsb pdb:4Q93|rcsb pdb:4QBT|rcsb pdb:5THH|rcsb pdb:5THL|reactome:R-HSA-379716|dip:DIP-50415N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y/0Qs8iOgW5w5LVLWnCvowVpEu89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14866	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719024|uniprotkb:Q9H3P3|uniprotkb:A6ND69|uniprotkb:A6NIT8|ensembl:ENSP00000221419|ensembl:ENSP00000489021	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpl_human(display_long)|uniprotkb:HNRPL(gene name synonym)|uniprotkb:HNRNPL(gene name)|psi-mi:HNRNPL(display_short)|uniprotkb:P/OKcl.14(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001005335.1|refseq:NP_001524.2|refseq:XP_011525191.1|ensembl:ENSG00000282947(gene)|ensembl:ENST00000221419(transcript)|ensembl:ENST00000634753(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097157"(pre-mRNA intronic binding)|ensembl:ENSG00000104824(gene)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979|mint:P14866|rcsb pdb:3R27|rcsb pdb:3TO8|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:1990904"(ribonucleoprotein complex)|dip:DIP-36355N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vOfznm03e6Ottg6BptYHmR9qJEc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NX63	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-743375|ensembl:ENSP00000262570	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42766	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356819|uniprotkb:Q4VBY5|uniprotkb:Q9BYF4|uniprotkb:Q5JTN5|uniprotkb:Q6IBC7|uniprotkb:Q96QJ7|uniprotkb:A8K4V7|ensembl:ENSP00000259469	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl35_human(display_long)|uniprotkb:RPL35(gene name)|psi-mi:RPL35(display_short)|uniprotkb:Large ribosomal subunit protein uL29(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009140.1|ensembl:ENSG00000136942(gene)|ensembl:ENST00000348462(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001854(Ribosomal protein L29)|interpro:IPR018254|interpro:IPR036049|mint:P42766|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jhzt7gCff2vdUb1Ff/VTBF698Pg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11021	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50402	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11388	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18206	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716775|uniprotkb:Q16450|uniprotkb:Q5SWX2|uniprotkb:Q7Z3B8|uniprotkb:Q8IXU7|ensembl:ENSP00000211998	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vinc_human(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003364.1|refseq:NP_054706.1|ensembl:ENSG00000035403(gene)|ensembl:ENST00000211998(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P18206|rcsb pdb:1RKC|rcsb pdb:1RKE|rcsb pdb:1SYQ|rcsb pdb:1TR2|rcsb pdb:1YDI|rcsb pdb:2GWW|rcsb pdb:2HSQ|rcsb pdb:2IBF|rcsb pdb:3H2U|rcsb pdb:3H2V|rcsb pdb:3JBK|rcsb pdb:3MYI|rcsb pdb:3RF3|rcsb pdb:3S90|go:"GO:0005198"(structural molecule activity)|rcsb pdb:3TJ5|rcsb pdb:3TJ6|rcsb pdb:3VF0|rcsb pdb:4DJ9|rcsb pdb:4EHP|rcsb pdb:4LN2|rcsb pdb:4LNP|rcsb pdb:4PR9|rcsb pdb:5L0C|rcsb pdb:5L0D|rcsb pdb:5L0F|rcsb pdb:5L0G|rcsb pdb:5L0H|rcsb pdb:5L0I|rcsb pdb:5L0J|rcsb pdb:5O2Q|rcsb pdb:6FUY|rcsb pdb:6UPW|rcsb pdb:7KTT|rcsb pdb:7KTU|rcsb pdb:7KTV|rcsb pdb:7KTW|reactome:R-HSA-114608|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|ensembl:ENSP00000211998|ensembl:ENST00000372755|ensembl:ENSP00000361841|dip:DIP-35570N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Cs5ZD4u5mH3IHBeKWMRV4cfS+y49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15020	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5A9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2878081|uniprotkb:B4E1G7|uniprotkb:A6NKG4|uniprotkb:Q5VSZ9|uniprotkb:Q8TDH0|uniprotkb:Q9BUJ5|uniprotkb:A8K966|uniprotkb:D3DPM8|ensembl:ENSP00000362918|ensembl:ENSP00000444660	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ythd2_human(display_long)|uniprotkb:HGRG8(gene name synonym)|uniprotkb:CLL-associated antigen KW-14(gene name synonym)|uniprotkb:High-glucose-regulated protein 8(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-2(gene name synonym)|uniprotkb:YTHDF2(gene name)|psi-mi:YTHDF2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001166299.1|refseq:NP_001166599.1|refseq:NP_057342.2|ensembl:ENSG00000198492(gene)|ensembl:ENST00000373812(transcript)|ensembl:ENST00000542507(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045087"(innate immune response)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070925"(organelle assembly)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:2000232"(regulation of rRNA processing)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR007275(YT521-B-like protein)|mint:Q9Y5A9|rcsb pdb:4RDO|rcsb pdb:4WQN|rcsb pdb:4RDN	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PF4C2t/728HqnrTyBQDJydH0G709606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NR56	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2805004|uniprotkb:O43797|uniprotkb:O43311|uniprotkb:Q86UV8|uniprotkb:Q96P92|uniprotkb:Q96RE3|uniprotkb:E9PBW7|uniprotkb:Q86UV9|ensembl:ENSP00000282486|ensembl:ENSP00000418108	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mbnl1_human(display_long)|uniprotkb:EXP(gene name synonym)|uniprotkb:KIAA0428(gene name synonym)|uniprotkb:MBNL(gene name synonym)|uniprotkb:Triplet-expansion RNA-binding protein(gene name synonym)|uniprotkb:MBNL1(gene name)|psi-mi:MBNL1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011511149.1|refseq:XP_011511151.1|refseq:NP_001300986.1|refseq:NP_066368.2|refseq:NP_997175.1|refseq:NP_997176.1|refseq:NP_997177.1|refseq:NP_997178.1|refseq:NP_997179.1|refseq:NP_997180.1|refseq:XP_005247523.1|refseq:XP_005247528.1|ensembl:ENSP00000282486|ensembl:ENST00000324196|ensembl:ENSP00000319374|ensembl:ENST00000324210|ensembl:ENSP00000319429|ensembl:ENST00000355460|ensembl:ENSP00000347637|ensembl:ENST00000357472|ensembl:ENSP00000350064|ensembl:ENSP00000418108|ensembl:ENST00000465907|ensembl:ENSP00000417630|ensembl:ENST00000485509|ensembl:ENSP00000418876|ensembl:ENST00000485910|ensembl:ENSP00000418427|ensembl:ENST00000492948|ensembl:ENSP00000420103|ensembl:ENST00000545754|ensembl:ENSP00000437491|interpro:IPR000571(Zinc finger, CCCH-type)|mint:Q9NR56|rcsb pdb:3D2N|rcsb pdb:3D2Q|rcsb pdb:3D2S|rcsb pdb:5U6H|rcsb pdb:5U6L|rcsb pdb:5U9B|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000152601(gene)|ensembl:ENST00000282486(transcript)|ensembl:ENST00000463374(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045445"(myoblast differentiation)|refseq:XP_016861914.1|refseq:XP_016861915.1|refseq:XP_016861916.1|refseq:XP_016861917.1|refseq:XP_016861918.1|refseq:XP_016861919.1|refseq:XP_016861920.1|refseq:XP_016861925.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uvyDik76f41mvxO2j/dUD6mKMOk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14979	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299727|ensembl:ENSP00000295470|ensembl:ENSP00000422040|ensembl:ENSP00000483254|uniprotkb:Q6SPF2|uniprotkb:Q7KZ74|uniprotkb:Q7KZ75|uniprotkb:Q96IM0|uniprotkb:Q96S43	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrdl_human(display_long)|uniprotkb:HNRNPDL(gene name)|psi-mi:HNRNPDL(display_short)|uniprotkb:AU-rich element RNA-binding factor(gene name synonym)|uniprotkb:HNRPDL(gene name synonym)|uniprotkb:JKT41-binding protein(gene name synonym)|uniprotkb:JKTBP(gene name synonym)|uniprotkb:Protein laAUF1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000152795(gene)|ensembl:ENST00000295470(transcript)|ensembl:ENST00000502762(transcript)|ensembl:ENST00000621267(transcript)|go:"GO:0003677"(DNA binding)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034847|interpro:IPR035979|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|mint:O14979|go:"GO:0003723"(RNA binding)|reactome:R-HSA-8950505|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034046"("poly(G) binding")|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001193929.1|refseq:NP_112740.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oOnEEar8AtKO5G6ldehucaRr4kM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24752	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1051459|uniprotkb:B2R6H1|uniprotkb:G3XAB4|uniprotkb:Q96FG8|ensembl:ENSP00000265838	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:thil_human(display_long)|uniprotkb:Acetoacetyl-CoA thiolase(gene name synonym)|uniprotkb:T2(gene name synonym)|uniprotkb:ACAT1(gene name)|psi-mi:ACAT1(display_short)|uniprotkb:ACAT(gene name synonym)|uniprotkb:MAT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000010.1|ensembl:ENSG00000075239(gene)|ensembl:ENST00000265838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007420"(brain development)|go:"GO:0009725"(response to hormone)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016453"(C-acetyltransferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0034435"(cholesterol esterification)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046356"(acetyl-CoA catabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072229"(metanephric proximal convoluted tubule development)|go:"GO:0120225"(coenzyme A binding)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1902860"(propionyl-CoA biosynthetic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|rcsb pdb:2F2S|rcsb pdb:2IB7|rcsb pdb:2IB8|rcsb pdb:2IB9|rcsb pdb:2IBU|rcsb pdb:2IBW|rcsb pdb:2IBY|reactome:R-HSA-70895|reactome:R-HSA-77108|reactome:R-HSA-77111	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UYAY+kDdcJqx/hrDFoXH9rgtm/E9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21796	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63173	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359141|uniprotkb:P23411|uniprotkb:B2R5A8|ensembl:ENSP00000309830|ensembl:ENSP00000390279|ensembl:ENSP00000434243	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl38_human(display_long)|uniprotkb:RPL38(gene name)|psi-mi:RPL38(display_short)|uniprotkb:Large ribosomal subunit protein eL38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000990.1|refseq:NP_001030335.1|ensembl:ENSG00000172809(gene)|ensembl:ENST00000311111(transcript)|ensembl:ENST00000439590(transcript)|ensembl:ENST00000533498(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0033291"(eukaryotic 80S initiation complex)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0048318"(axial mesoderm development)|interpro:IPR002675(Ribosomal protein L38e)|interpro:IPR038464|mint:P63173|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:5AJ0|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6kUSGJll3ldTTRzgVTSwBjgV19Y9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75146	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14671	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-948453|ensembl:ENSP00000257075|uniprotkb:Q5VXY7|uniprotkb:Q9HAN1|intact:EBI-2842591|uniprotkb:E9PCJ0|uniprotkb:Q53HH5|uniprotkb:B4DG92|uniprotkb:A8K6W4|uniprotkb:D3DPN3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pum1_human(display_long)|uniprotkb:PUM1(gene name)|psi-mi:PUM1(display_short)|uniprotkb:KIAA0099(gene name synonym)|uniprotkb:PUMH1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134644(gene)|ensembl:ENST00000257075(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048863"(stem cell differentiation)|interpro:IPR033712|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0061157"(mRNA destabilization)|mint:Q14671|rcsb pdb:1IB2|rcsb pdb:1M8W|rcsb pdb:1M8X|rcsb pdb:1M8Y|rcsb pdb:1M8Z|rcsb pdb:2YJY|rcsb pdb:3BSB|rcsb pdb:3BSX|rcsb pdb:3Q0L|rcsb pdb:3Q0M|rcsb pdb:3Q0N|rcsb pdb:3Q0O|rcsb pdb:3Q0P|rcsb pdb:5YKH|rcsb pdb:5YKI|reactome:R-HSA-432722|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001313(Pumilio RNA-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033133|refseq:NP_001018494.1|refseq:NP_055491.1|dip:DIP-29082N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tGsSgrvQ/Ehnm3UC5IO4CHhCrFs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46777	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358018|ensembl:ENSP00000359345|uniprotkb:Q53HH6|uniprotkb:Q9H3F4|uniprotkb:Q32LZ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl5_human(display_long)|uniprotkb:RPL5(gene name)|psi-mi:RPL5(display_short)|uniprotkb:Large ribosomal subunit protein uL18(gene name synonym)|uniprotkb:MSTP030(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|ensembl:ENSG00000122406(gene)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|ensembl:ENST00000370321(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|refseq:NP_000960.2|dip:DIP-31152N|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|mint:P46777|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rs+zAc+IPrEqv7DHNcy2GIkQkfY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62701	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354303|uniprotkb:P12631|uniprotkb:P12750|uniprotkb:P27576|uniprotkb:Q14727|uniprotkb:P55831|uniprotkb:Q6IPY4|ensembl:ENSP00000362744	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs4x_human(display_long)|uniprotkb:RPS4X(gene name)|psi-mi:RPS4X(display_short)|uniprotkb:CCG2(gene name synonym)|uniprotkb:RPS4(gene name synonym)|uniprotkb:SCAR(gene name synonym)|uniprotkb:Single copy abundant mRNA protein(gene name synonym)|uniprotkb:SCR10(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000998.1|rcsb pdb:6OLI|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000198034(gene)|ensembl:ENST00000316084(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005824(KOW)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR018199|interpro:IPR032277|interpro:IPR036986|interpro:IPR038237|interpro:IPR041982|mint:P62701|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|go:"GO:0045727"(positive regulation of translation)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2ZuLXqBSDkK0CtN3mnIDoFAR8yI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27635	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352398|uniprotkb:A3KQT0|uniprotkb:Q16470|uniprotkb:Q2HXT7|uniprotkb:Q53FH7|uniprotkb:Q6FGN8|uniprotkb:Q8TDA5|intact:EBI-3046680|uniprotkb:D3DWW6|ensembl:ENSP00000341730|ensembl:ENSP00000358832	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl10_human(display_long)|uniprotkb:RPL10(gene name)|psi-mi:RPL10(display_short)|uniprotkb:QM(gene name synonym)|uniprotkb:Protein QM(gene name synonym)|uniprotkb:Tumor suppressor QM(gene name synonym)|uniprotkb:Laminin receptor homolog(gene name synonym)|uniprotkb:DXS648E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL16(gene name synonym)|uniprotkb:Ribosomal protein L10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243506.2|refseq:NP_001243509.2|refseq:NP_001290553.1|refseq:NP_001290554.1|refseq:NP_001290555.1|ensembl:ENSG00000147403(gene)|ensembl:ENST00000344746(transcript)|ensembl:ENST00000369817(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|refseq:NP_006004.3|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001197(Ribosomal protein L10e)|interpro:IPR016180(Ribosomal protein L10e/L16)|interpro:IPR018255|interpro:IPR036920|mint:P27635|rcsb pdb:2PA2|rcsb pdb:5AJ0|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6W6L|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|go:"GO:0016020"(membrane)|reactome:R-HSA-975957|dip:DIP-1133N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wJnBcv39yvVz2CaZq8UKgxIpJeE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38159	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-743526|ensembl:ENSP00000359645|uniprotkb:Q5JQ67|uniprotkb:Q969R3|uniprotkb:D3DWH0|uniprotkb:E9PG86|uniprotkb:Q8N8Y7|uniprotkb:B4E3U4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbmx_human(display_long)|uniprotkb:Glycoprotein p43(gene name synonym)|uniprotkb:RBMX(gene name)|psi-mi:RBMX(display_short)|uniprotkb:HNRPG(gene name synonym)|uniprotkb:RBMXP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein G(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000147274(gene)|ensembl:ENST00000320676(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012604(RBM1CTR)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P38159|rcsb pdb:2MB0|rcsb pdb:2MKS|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:NP_002130.2|refseq:NP_001158275.1|dip:DIP-34447N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ocCkdy9PxjeVLUQf0tMVCEhFfO89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24666	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-717701|uniprotkb:P24667|uniprotkb:Q16035|uniprotkb:Q53RU0|uniprotkb:Q16036|uniprotkb:Q16725|uniprotkb:Q3KQX8|uniprotkb:A8K1L9|uniprotkb:B5MCC7|ensembl:ENSP00000272065	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppac_human(display_long)|uniprotkb:Low molecular weight cytosolic acid phosphatase(gene name synonym)|uniprotkb:Red cell acid phosphatase 1(gene name synonym)|uniprotkb:Adipocyte acid phosphatase(gene name synonym)|uniprotkb:ACP1(gene name)|psi-mi:ACP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004291.1|refseq:NP_009030.1|ensembl:ENSG00000143727(gene)|ensembl:ENST00000272065(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002115(Protein-tyrosine phosphatase, low molecular weight, mammalian)|interpro:IPR017867|interpro:IPR023485|interpro:IPR036196|mint:P24666|rcsb pdb:1XWW|rcsb pdb:3N8I|rcsb pdb:4Z99|rcsb pdb:4Z9A|rcsb pdb:4Z9B|rcsb pdb:5JNR|rcsb pdb:5JNS|rcsb pdb:5JNT|rcsb pdb:5KQG|rcsb pdb:5KQL|rcsb pdb:5KQM|rcsb pdb:5KQP|rcsb pdb:5PNT|rcsb pdb:6Y2V|rcsb pdb:6Y2W|rcsb pdb:7KH8	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:j4VyGaaWO8l/Ah8i1HBU6EnbK289606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8NI36	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2512413|ensembl:ENSP00000423067|ensembl:ENSP00000479950|uniprotkb:A2RUS4|uniprotkb:Q8N1Q2|uniprotkb:Q68E02	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:wdr36_human(display_long)|uniprotkb:WDR36(gene name)|psi-mi:WDR36(display_short)|uniprotkb:T-cell activation WD repeat-containing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134987(gene)|ensembl:ENST00000506538(transcript)|ensembl:ENST00000612402(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007601"(visual perception)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|go:"GO:0050896"(response to stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR007319(Small-subunit processome, Utp21)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|refseq:NP_644810.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:97Qc0ehUPTjCBcn3gjr0FY8Nnus9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36578	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348313|ensembl:ENSP00000311430|uniprotkb:P39029|uniprotkb:Q4VBR0|uniprotkb:Q969Z9|uniprotkb:A8K502	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl4_human(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:RPL1(gene name synonym)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000174444(gene)|ensembl:ENST00000307961(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR025755|mint:P36578|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|interpro:IPR023574|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OM0|refseq:NP_000959.2|dip:DIP-27559N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:34il/jyrW0Dqj0eA8GBFgUk05XU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99714	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-79964|ensembl:ENSP00000168216|uniprotkb:Q8TCV9|uniprotkb:Q96HD5|uniprotkb:Q5H927|uniprotkb:Q6IBS9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hcd2_human(display_long)|uniprotkb:HSD17B10(gene name)|psi-mi:HSD17B10(display_short)|uniprotkb:SCHAD(gene name synonym)|uniprotkb:XH98G2(gene name synonym)|uniprotkb:HADH2(gene name synonym)|uniprotkb:3-hydroxyacyl-CoA dehydrogenase type II(gene name synonym)|uniprotkb:Type II HADH(gene name synonym)|uniprotkb:3-hydroxy-2-methylbutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:Endoplasmic reticulum-associated amyloid beta-peptide-binding protein(gene name synonym)|uniprotkb:Short-chain type dehydrogenase/reductase XH98G2(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 2(gene name synonym)|uniprotkb:2-methyl-3-hydroxybutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:ERAB(gene name synonym)|uniprotkb:MRPP2(gene name synonym)|uniprotkb:SDR5C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 5C member 1(gene name synonym)|uniprotkb:17-beta-estradiol 17-dehydrogenase(gene name synonym)|uniprotkb:"3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))"(gene name synonym)|uniprotkb:"3alpha(or 20beta)-hydroxysteroid dehydrogenase"(gene name synonym)|uniprotkb:7-alpha-hydroxysteroid dehydrogenase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:2O23|reactome:R-HSA-6785470|reactome:R-HSA-6787450|reactome:R-HSA-70895|reactome:R-HSA-8868766|ensembl:ENSG00000072506(gene)|ensembl:ENST00000168216(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008207"(C21-steroid hormone metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008709"(cholate 7-alpha-dehydrogenase activity)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0047015"(3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity)|go:"GO:0047035"("testosterone dehydrogenase (NAD+) activity")|go:"GO:0047044"(androstan-3-alpha,17-beta-diol dehydrogenase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0062173"(brexanolone metabolic process)|go:"GO:0070901"(mitochondrial tRNA methylation)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|go:"GO:0106281"("chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity")|go:"GO:0106282"("isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:0106283"("ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q99714|rcsb pdb:1F67|rcsb pdb:1SO8|rcsb pdb:1U7T|refseq:NP_001032900.1|refseq:NP_004484.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:q6/pRFyay7gQ6bb2rzvKYgfkeaE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19320	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09382	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048875|uniprotkb:B2R5E8|uniprotkb:Q9UDK5|ensembl:ENSP00000215909	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:leg1_human(display_long)|uniprotkb:Lectin galactoside-binding soluble 1(gene name synonym)|uniprotkb:Beta-galactoside-binding lectin L-14-I(gene name synonym)|uniprotkb:S-Lac lectin 1(gene name synonym)|uniprotkb:Galaptin(gene name synonym)|uniprotkb:14 kDa lectin(gene name synonym)|uniprotkb:HPL(gene name synonym)|uniprotkb:HBL(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM12(gene name synonym)|uniprotkb:LGALS1(gene name)|psi-mi:LGALS1(display_short)|uniprotkb:Lactose-binding lectin 1(gene name synonym)|uniprotkb:14 kDa laminin-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002296.1|ensembl:ENST00000215909(transcript)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030395"(lactose binding)|ensembl:ENSG00000100097(gene)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR044156|mint:P09382|rcsb pdb:1GZW|rcsb pdb:1W6M|rcsb pdb:1W6N|rcsb pdb:1W6O|rcsb pdb:1W6P|rcsb pdb:1W6Q|rcsb pdb:2KM2|rcsb pdb:2ZKN|rcsb pdb:3OY8|rcsb pdb:3OYW|rcsb pdb:3T2T|rcsb pdb:3W58|rcsb pdb:3W59|rcsb pdb:4Q1P|go:"GO:0031295"(T cell costimulation)|go:"GO:0034120"(positive regulation of erythrocyte aggregation)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043236"(laminin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0048678"(response to axon injury)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4Q1R|rcsb pdb:4Q26|rcsb pdb:4Q27|rcsb pdb:4Q2F|rcsb pdb:4XBL|rcsb pdb:4Y1U|rcsb pdb:4Y1V|rcsb pdb:4Y1X|rcsb pdb:4Y1Y|rcsb pdb:4Y1Z|rcsb pdb:4Y20|rcsb pdb:4Y22|rcsb pdb:4Y24|rcsb pdb:5MWT|rcsb pdb:5MWX|rcsb pdb:6B94|rcsb pdb:6F83|rcsb pdb:6M5Y|reactome:R-HSA-381426|reactome:R-HSA-8957275|dip:DIP-46153N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Sov3RfY2NOjdjuvdFlEd/vaNTMY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60228	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:s09LicCa0mb9WwO7esZvVdvUonY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-726937|uniprotkb:Q6NZ54|uniprotkb:Q7M4M5|uniprotkb:Q3KQW2|uniprotkb:B2R4H3|uniprotkb:B4E3C2|uniprotkb:B5ME31|uniprotkb:J3QL51|ensembl:ENSP00000462023|ensembl:ENSP00000462385|ensembl:ENSP00000463842|ensembl:ENSP00000480555|ensembl:ENSP00000482577	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl17_human(display_long)|uniprotkb:60S ribosomal protein L23(gene name synonym)|uniprotkb:PD-1(gene name synonym)|uniprotkb:RPL17(gene name)|psi-mi:RPL17(display_short)|uniprotkb:Large ribosomal subunit protein uL22(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000976.1|refseq:NP_001030178.1|refseq:NP_001186269.1|refseq:NP_001186270.1|refseq:NP_001186271.1|refseq:NP_001186272.1|refseq:NP_001186273.1|refseq:NP_001186274.1|ensembl:ENSG00000265681(gene)|ensembl:ENST00000579248(transcript)|ensembl:ENST00000579408(transcript)|ensembl:ENST00000580261(transcript)|ensembl:ENST00000618613(transcript)|ensembl:ENST00000618619(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001063(Ribosomal protein L22/L17)|interpro:IPR005721(Ribosomal protein L22/L17, eukaryotic/archaeal)|interpro:IPR018260|interpro:IPR036394|mint:P18621|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/i0W3WoeFakz+8R/YMYf2JQZytI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75694	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050769|uniprotkb:Q9UBE9|uniprotkb:Q9UFL5|intact:EBI-28983292|ensembl:ENSP00000231498	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu155_human(display_long)|uniprotkb:Nucleoporin Nup155(gene name synonym)|uniprotkb:155 kDa nucleoporin(gene name synonym)|uniprotkb:KIAA0791(gene name synonym)|uniprotkb:NUP155(gene name)|psi-mi:NUP155(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004289.1|refseq:NP_705618.1|ensembl:ENSP00000231498|ensembl:ENST00000381843|ensembl:ENSP00000371265|ensembl:ENSG00000113569(gene)|ensembl:ENST00000231498(transcript)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036228"(protein localization to nuclear inner membrane)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|interpro:IPR004870(Nucleoporin, non-repetitive/WGA-negative)|interpro:IPR007187(Nucleoporin, Nup133-like, C-terminal)|interpro:IPR014908(Nup133, N-terminal)|interpro:IPR042533|interpro:IPR042537|interpro:IPR042538|rcsb pdb:5A9Q|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k6LjWvJdqtT78G4Wu12rJX/2WHo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46782	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350569|uniprotkb:Q96BN0|uniprotkb:B2R4T2|ensembl:ENSP00000196551|ensembl:ENSP00000470114|ensembl:ENSP00000472985	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs5_human(display_long)|uniprotkb:RPS5(gene name)|psi-mi:RPS5(display_short)|uniprotkb:Small ribosomal subunit protein uS7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001000.2|rcsb pdb:6OLZ|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Z6M|rcsb pdb:6XA1|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6Y0G|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:5FLX|rcsb pdb:6OLG|rcsb pdb:6OLI|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|ensembl:ENSG00000083845(gene)|ensembl:ENST00000196551(transcript)|ensembl:ENST00000596046(transcript)|ensembl:ENST00000601521(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823|mint:P46782|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:5AJ0|reactome:R-HSA-72702	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SoCJdf2InngZZtlz5qD1k5CEfEo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7L2E3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1211456|uniprotkb:O94965|uniprotkb:Q7Z753|uniprotkb:Q96CH4|uniprotkb:Q9NUQ0|uniprotkb:A8K5F1|ensembl:ENSP00000392601|ensembl:ENSP00000405620|intact:EBI-21350949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx30_human(display_long)|uniprotkb:DHX30(gene name)|psi-mi:DHX30(display_short)|uniprotkb:KIAA0890(gene name synonym)|uniprotkb:DDX30(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055781.2|refseq:NP_619520.1|refseq:XP_011531796.1|refseq:XP_011531797.1|refseq:XP_016861406.1|ensembl:ENSG00000132153(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007417"(central nervous system development)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q7L2E3|rcsb pdb:2DB2|ensembl:ENST00000445061(transcript)|ensembl:ENST00000446256(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tb4GzZKLycraXS0NlVqj8reV3IQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62750	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353254|uniprotkb:P29316|uniprotkb:Q92774|uniprotkb:P39024|uniprotkb:B2R5B2|ensembl:ENSP00000389103	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl23a_human(display_long)|uniprotkb:RPL23A(gene name)|psi-mi:RPL23A(display_short)|uniprotkb:Large ribosomal subunit protein uL23(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|refseq:NP_000975.2|ensembl:ENSG00000198242(gene)|ensembl:ENST00000422514(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904841"(TORC2 complex binding)|interpro:IPR001014(Ribosomal protein L23, conserved site)|interpro:IPR005633(Ribosomal protein L23/L25, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|interpro:IPR019985|mint:P62750|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lA1ubRFO9/Tl54Z1dKUzoCKvpAo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60231	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-311446|uniprotkb:O60322|uniprotkb:Q969X7|uniprotkb:Q96QC1|uniprotkb:Q5JP45|ensembl:ENSP00000365625|ensembl:ENSP00000373071|ensembl:ENSP00000389862|ensembl:ENSP00000390938|ensembl:ENSP00000393958|ensembl:ENSP00000396193|ensembl:ENSP00000408956	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx16_human(display_long)|uniprotkb:DHX16(gene name)|psi-mi:DHX16(display_short)|uniprotkb:DBP2(gene name synonym)|uniprotkb:DDX16(gene name synonym)|uniprotkb:KIAA0577(gene name synonym)|uniprotkb:DEAH-box protein 16(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #3(gene name synonym)|uniprotkb:PRP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001157711.1|refseq:NP_003578.2|ensembl:ENSG00000204560(gene)|ensembl:ENSG00000206486(gene)|ensembl:ENSG00000226171(gene)|ensembl:ENSG00000231377(gene)|ensembl:ENSG00000233049(gene)|ensembl:ENSG00000233418(gene)|ensembl:ENSG00000233561(gene)|ensembl:ENST00000376442(transcript)|ensembl:ENST00000383577(transcript)|ensembl:ENST00000417308(transcript)|ensembl:ENST00000421095(transcript)|ensembl:ENST00000424672(transcript)|ensembl:ENST00000451456(transcript)|ensembl:ENST00000458094(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF7|rcsb pdb:7DVQ|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sYCQp3qc9+wukR7aCf2qen2dgdU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15942	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-444225|ensembl:ENSP00000324422|ensembl:ENSP00000494798|uniprotkb:Q6I9S4|uniprotkb:A4D2G6|uniprotkb:B4DQX7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:zyx_human(display_long)|uniprotkb:Zyxin-2(gene name synonym)|uniprotkb:ZYX(gene name)|psi-mi:ZYX(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000159840(gene)|ensembl:ENSG00000285443(gene)|ensembl:ENST00000322764(transcript)|ensembl:ENST00000646695(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001781(Zinc finger, LIM-type)|go:"GO:0043149"(stress fiber assembly)|refseq:NP_001010972.1|refseq:NP_003452.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4UC6NVZHDUrTy4sPhz7e7RpPwho9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5K6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y262	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q07020	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352694|intact:EBI-8456577|intact:MINT-8429255|uniprotkb:F8VWC5|uniprotkb:Q8WTZ6|ensembl:ENSP00000447001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl18_human(display_long)|uniprotkb:RPL18(gene name)|psi-mi:RPL18(display_short)|uniprotkb:Large ribosomal subunit protein eL18(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000970.1|ensembl:ENSG00000063177(gene)|ensembl:ENST00000549920(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000039(Ribosomal protein L18e)|interpro:IPR021131|interpro:IPR021132|interpro:IPR036227|mint:Q07020|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001257419.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GgzBcLEQgBqbApFlaQIU2jktkAE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P47897	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347462|uniprotkb:B4DWJ2|ensembl:ENSP00000307567	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syq_human(display_long)|uniprotkb:QARS1(gene name)|psi-mi:QARS1(display_short)|uniprotkb:Glutaminyl-tRNA synthetase(gene name synonym)|uniprotkb:QARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005042.1|ensembl:ENSG00000172053(gene)|ensembl:ENST00000306125(transcript)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004514(Glutaminyl-tRNA synthetase, class Ic)|interpro:IPR007638(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 2)|interpro:IPR007639(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 1)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR042558|interpro:IPR042559|mint:P47897|rcsb pdb:4R3Z|rcsb pdb:4YE6|rcsb pdb:4YE8|rcsb pdb:4YE9|reactome:R-HSA-2408522|go:"GO:0006469"(negative regulation of protein kinase activity)|reactome:R-HSA-379716|reactome:R-HSA-379726|go:"GO:0007420"(brain development)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_001259002.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Q8LR+aWJJue/ixtD3ZYDpC/D3o9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P45880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:seQxCd19Z2HmpXcwb48osAuuafA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62753	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356625|uniprotkb:P08227|uniprotkb:P10660|uniprotkb:Q4VBY7|uniprotkb:Q8N6Z7|ensembl:ENSP00000369757	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs6_human(display_long)|uniprotkb:RPS6(gene name)|psi-mi:RPS6(display_short)|uniprotkb:Phosphoprotein NP33(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS6(gene name synonym)|uniprotkb:OK/SW-cl.2(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001001.2|reactome:R-HSA-166208|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR014401(Ribosomal protein S6, eukaryotic)|interpro:IPR018282|mint:P62753|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6F4P|rcsb pdb:6F4Q|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|ensembl:ENSG00000137154(gene)|ensembl:ENST00000380394(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001890"(placenta development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022605"(mammalian oogenesis stage)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0031929"(TOR signaling)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048821"(erythrocyte development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001377(Ribosomal protein S6e)|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|dip:DIP-31507N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:beDuXCIqL99V9JlVfpzx7MdpH689606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92900	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373471|uniprotkb:O00239|uniprotkb:O43343|uniprotkb:Q86Z25|uniprotkb:Q92842|ensembl:ENSP00000470142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rent1_human(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:RENT1(gene name synonym)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002902.2|refseq:NP_001284478.1|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000599848(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q92900|rcsb pdb:2GJK|rcsb pdb:2GK6|rcsb pdb:2GK7|rcsb pdb:2IYK|rcsb pdb:2WJV|rcsb pdb:2WJY|rcsb pdb:2XZO|rcsb pdb:2XZP|rcsb pdb:6EJ5|rcsb pdb:6Z3R|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0006406"(mRNA export from nucleus)|dip:DIP-29875N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ORqXFPAa7qA8cwM5qcNodIF0q/s9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61254	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352405|uniprotkb:Q02877|uniprotkb:Q6IPY2|uniprotkb:B2R4F0|uniprotkb:D3DTR8|ensembl:ENSP00000462322|ensembl:ENSP00000463470|ensembl:ENSP00000463784|ensembl:ENSP00000498177	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl26_human(display_long)|uniprotkb:RPL26(gene name)|psi-mi:RPL26(display_short)|uniprotkb:Large ribosomal subunit protein uL24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000978.1|refseq:NP_001302459.1|refseq:NP_001302460.1|ensembl:ENST00000582556(transcript)|ensembl:ENST00000583011(transcript)|ensembl:ENST00000584164(transcript)|ensembl:ENST00000648839(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|ensembl:ENSG00000161970(gene)|go:"GO:0022626"(cytosolic ribosome)|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:1902164"(positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1904803"(regulation of translation involved in cellular response to UV)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005756(Ribosomal protein L26, eukaryotic/archaeal)|interpro:IPR005824(KOW)|interpro:IPR005825(Ribosomal protein L24/L26, conserved site)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041988|mint:P61254|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|go:"GO:0034644"(cellular response to UV)|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|rcsb pdb:5LKS|reactome:R-HSA-156827|dip:DIP-33198N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VAROWOFmYvolVgc/e5E1jAmNuaY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q86XP3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722353|uniprotkb:A6NML1|uniprotkb:O75619|uniprotkb:Q68G51|uniprotkb:Q96BK1|uniprotkb:Q96HR7|uniprotkb:Q9Y3V8|uniprotkb:A8KA43|intact:EBI-2555393|ensembl:ENSP00000374574|ensembl:ENSP00000463561|ensembl:ENSP00000464050	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx42_human(display_long)|uniprotkb:DEAD box protein 42(gene name synonym)|uniprotkb:Splicing factor 3B-associated 125 kDa protein(gene name synonym)|uniprotkb:RNA helicase-related protein(gene name synonym)|uniprotkb:RNA helicase-like protein(gene name synonym)|uniprotkb:SF3b DEAD box protein(gene name synonym)|uniprotkb:DDX42(gene name)|psi-mi:DDX42(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_031398.2|refseq:NP_987095.1|refseq:XP_006721720.1|refseq:XP_016879600.1|ensembl:ENSG00000198231(gene)|ensembl:ENST00000389924(transcript)|ensembl:ENST00000578681(transcript)|ensembl:ENST00000583590(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q86XP3|reactome:R-HSA-72163|reactome:R-HSA-72165	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3vZn92rr6cO8qSZJdyq1fguSc489606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01813	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359022|uniprotkb:B3KS15|uniprotkb:Q5VSR7|uniprotkb:Q5VSR8|ensembl:ENSP00000370517	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfkap_human(display_long)|uniprotkb:PFKP(gene name)|psi-mi:PFKP(display_short)|uniprotkb:PFKF(gene name synonym)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme C(gene name synonym)|uniprotkb:6-phosphofructokinase type C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002618.1|ensembl:ENSG00000067057(gene)|ensembl:ENST00000381125(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:Q01813|rcsb pdb:4RH3|rcsb pdb:4U1R|rcsb pdb:4WL0|rcsb pdb:4XYJ|rcsb pdb:4XYK|rcsb pdb:4XZ2|reactome:R-HSA-70171|refseq:NP_001229268.1|dip:DIP-45850N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GNmWbFrQsTMRdVphWG+3DK3wxaA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P67870	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26373	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356849|uniprotkb:Q3KQT8|uniprotkb:Q9BPX0|uniprotkb:Q567Q8|uniprotkb:B4DLX3|uniprotkb:F5H1S2|ensembl:ENSP00000307889|ensembl:ENSP00000376811|ensembl:ENSP00000455009	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl13_human(display_long)|uniprotkb:RPL13(gene name)|psi-mi:RPL13(display_short)|uniprotkb:BBC1(gene name synonym)|uniprotkb:Breast basic conserved protein 1(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL13(gene name synonym)|uniprotkb:OK/SW-cl.46(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000968.2|refseq:NP_150254.1|refseq:NP_001230059.1|refseq:NP_001230060.1|ensembl:ENSG00000167526(gene)|ensembl:ENST00000311528(transcript)|ensembl:ENST00000393099(transcript)|ensembl:ENST00000567815(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0060348"(bone development)|interpro:IPR001380(Ribosomal protein L13e)|interpro:IPR018256|mint:P26373|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-192823	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2SZ+AEe41Ystwj9t9I0Z1cZ5GQ49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q86UX7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373158|uniprotkb:Q8IUA1|uniprotkb:Q8N207|uniprotkb:Q9BT48|ensembl:ENSP00000279227	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:urp2_human(display_long)|uniprotkb:FERMT3(gene name)|psi-mi:FERMT3(display_short)|uniprotkb:KIND3(gene name synonym)|uniprotkb:MIG2B(gene name synonym)|uniprotkb:URP2(gene name synonym)|uniprotkb:Unc-112-related protein 2(gene name synonym)|uniprotkb:Kindlin-3(gene name synonym)|uniprotkb:MIG2-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_113659.3|refseq:NP_848537.1|refseq:XP_011543596.1|ensembl:ENSG00000149781(gene)|ensembl:ENST00000279227(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042995"(cell projection)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR037837|interpro:IPR037843|interpro:IPR040790|rcsb pdb:2YS3|rcsb pdb:6V97|rcsb pdb:6V9G|rcsb pdb:7C3M|reactome:R-HSA-114608|refseq:XP_016873887.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BDLaeBD6Ycz4HAh/4QlZeSZurxY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96PK6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-954272|ensembl:ENSP00000311747|uniprotkb:O75932|uniprotkb:Q53GV1|uniprotkb:Q68DQ9|uniprotkb:Q96PK5|uniprotkb:B3KMN4|uniprotkb:Q2PYN1|uniprotkb:D6RGD8|uniprotkb:B0LM41|intact:EBI-16430855|intact:EBI-16472484	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm14_human(display_long)|uniprotkb:RNA-binding motif protein 14(gene name synonym)|uniprotkb:RRM-containing coactivator activator/modulator(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein(gene name synonym)|uniprotkb:RBM14(gene name)|psi-mi:RBM14(display_short)|uniprotkb:SIP(gene name synonym)|uniprotkb:Paraspeckle protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000239306(gene)|ensembl:ENST00000310137(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009725"(response to hormone)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034506|interpro:IPR034507|go:"GO:0098534"(centriole assembly)|interpro:IPR035979|mint:Q96PK6|rcsb pdb:2DNP|reactome:R-HSA-8941326|refseq:NP_001185765.1|refseq:NP_006319.1|ensembl:ENSP00000311747|ensembl:ENST00000393979|ensembl:ENSP00000377548|ensembl:ENST00000409738|ensembl:ENSP00000386995|refseq:NP_001185766.1|refseq:NP_001185774.1|dip:DIP-50126N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Q0UBl2qmfwQTPwUQ7ZDwGIMOYoA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30043	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2837485|uniprotkb:P53005|uniprotkb:P32078|uniprotkb:Q32LZ2|uniprotkb:B2R5C6|uniprotkb:A6NKD8|ensembl:ENSP00000263368	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:blvrb_human(display_long)|uniprotkb:BLVRB(gene name)|psi-mi:BLVRB(display_short)|uniprotkb:FLR(gene name synonym)|uniprotkb:Biliverdin reductase B(gene name synonym)|uniprotkb:Biliverdin-IX beta-reductase(gene name synonym)|uniprotkb:Green heme-binding protein(gene name synonym)|uniprotkb:NADPH-dependent diaphorase(gene name synonym)|uniprotkb:NADPH-flavin reductase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000704.1|ensembl:ENSG00000090013(gene)|ensembl:ENST00000263368(transcript)|go:"GO:0004074"("biliverdin reductase (NAD(P)+) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042602"("riboflavin reductase (NADPH) activity")|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106276"(biliberdin reductase NAD+ activity)|go:"GO:0106277"("biliverdin reductase (NADP+) activity")|interpro:IPR016040("NAD(P)-binding")|interpro:IPR036291|rcsb pdb:1HDO|rcsb pdb:1HE2|rcsb pdb:1HE3|rcsb pdb:1HE4|rcsb pdb:1HE5|rcsb pdb:5OOG|rcsb pdb:5OOH|rcsb pdb:6OPL|reactome:R-HSA-189483|reactome:R-HSA-9707564	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dAGhnUTdZxBN2cUpArtdmrVdeKw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62081	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354360|uniprotkb:Q6IPH1|uniprotkb:P23821|uniprotkb:P24818|uniprotkb:Q57Z92|ensembl:ENSP00000385018|ensembl:ENSP00000385286|ensembl:ENSP00000495273|ensembl:ENSP00000496654|ensembl:ENSP00000496757	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs7_human(display_long)|uniprotkb:RPS7(gene name)|psi-mi:RPS7(display_short)|uniprotkb:Small ribosomal subunit protein eS7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002.1|ensembl:ENSG00000171863(gene)|ensembl:ENST00000403564(transcript)|ensembl:ENST00000406376(transcript)|ensembl:ENST00000462576(transcript)|ensembl:ENST00000645674(transcript)|ensembl:ENST00000646909(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000554(Ribosomal protein S7e)|mint:P62081|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6G4S	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l4aG6I34lmzYhNapbdv2CAAwRwg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12931	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237119|uniprotkb:Q52LW9|uniprotkb:B2R5A3|ensembl:ENSP00000366618	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h2b1l_human(display_long)|uniprotkb:H2BC13(gene name)|psi-mi:H2BC13(display_short)|uniprotkb:H2BFC(gene name synonym)|uniprotkb:HIST1H2BL(gene name synonym)|uniprotkb:Histone H2B.c(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003510.1|dip:DIP-38154N|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|ensembl:ENSG00000185130(gene)|ensembl:ENST00000377401(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|interpro:IPR009072(Histone-fold)|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5250924|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vVD3xoHavMKCopzEez7zarZBKFc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39023	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056348|uniprotkb:Q15548|uniprotkb:Q5I0G0|uniprotkb:B2RDV9|ensembl:ENSP00000346001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl3_human(display_long)|uniprotkb:RPL3(gene name)|psi-mi:RPL3(display_short)|uniprotkb:HIV-1 TAR RNA-binding protein B(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL3(gene name synonym)|uniprotkb:OK/SW-cl.32(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000958.1|ensembl:ENSG00000100316(gene)|ensembl:ENST00000216146(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P39023|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:j3MVAYfO/bziJBPmH4zCFqFskZ89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P99999	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32969	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358122|ensembl:ENSP00000346022|ensembl:ENSP00000400467|ensembl:ENSP00000494697	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl9_human(display_long)|uniprotkb:RPL9(gene name)|psi-mi:RPL9(display_short)|uniprotkb:RPL9P7(gene name)|psi-mi:RPL9P7(display_short)|uniprotkb:RPL9P8(gene name)|psi-mi:RPL9P8(display_short)|uniprotkb:RPL9P9(gene name)|psi-mi:RPL9P9(display_short)|uniprotkb:Large ribosomal subunit protein uL6(gene name synonym)|uniprotkb:OK/SW-cl.103(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000652.2|refseq:NP_001020092.1|ensembl:ENSG00000163682(gene)|ensembl:ENST00000295955(transcript)|ensembl:ENST00000449470(transcript)|ensembl:ENST00000645496(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR000702(Ribosomal protein L6)|interpro:IPR002359(Ribosomal protein L6, conserved site-2)|interpro:IPR020040|interpro:IPR036789|mint:P32969|rcsb pdb:2CQL|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:v0thFydYo0aEqBblJoqQX8b7JCA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8IX12	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356265|ensembl:ENSP00000265872|uniprotkb:A0JLT7|uniprotkb:A1L4P7|uniprotkb:A8K9D4|uniprotkb:B4DNP8|uniprotkb:B4DRK8|uniprotkb:Q5EBM3|uniprotkb:Q32NE3|uniprotkb:Q5VUP6|uniprotkb:Q6PIZ0|uniprotkb:Q6X935|uniprotkb:Q9H8N4|uniprotkb:Q9NVA7|uniprotkb:Q9NVQ0|uniprotkb:Q9NWM6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ccar1_human(display_long)|uniprotkb:CCAR1(gene name)|psi-mi:CCAR1(display_short)|uniprotkb:CARP1(gene name synonym)|uniprotkb:DIS(gene name synonym)|uniprotkb:Cell cycle and apoptosis regulatory protein 1(gene name synonym)|uniprotkb:Death inducer with SAP domain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000060339(gene)|ensembl:ENST00000265872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR011992(EF-Hand type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR036361|mint:Q8IX12|reactome:R-HSA-72163|refseq:NP_060707.2|refseq:NP_001269888.1|refseq:NP_001269889.1|dip:DIP-27607N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YnZve7StC4kAO8raUbp8T02jpe09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40429	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-720205|uniprotkb:A8K505|ensembl:ENSP00000375730	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl13a_human(display_long)|uniprotkb:23 kDa highly basic protein(gene name synonym)|uniprotkb:RPL13A(gene name)|psi-mi:RPL13A(display_short)|uniprotkb:Large ribosomal subunit protein uL13(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036555.1|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|rcsb pdb:6OLF|ensembl:ENSG00000142541(gene)|ensembl:ENST00000391857(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1901194"(negative regulation of formation of translation preinitiation complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005755(Ribosomal protein L13, eukaryotic/archaeal)|interpro:IPR005822(Ribosomal protein L13)|interpro:IPR023563|interpro:IPR036899|mint:P40429|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|refseq:NP_001257420.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pcKDTEBZXxtm1MAH+4nv0p3PqFs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BZX2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053938|uniprotkb:Q5VV91|uniprotkb:Q7KZV3|uniprotkb:Q92528|uniprotkb:Q96KG5|uniprotkb:Q9BU42|ensembl:ENSP00000356853|intact:EBI-21355463	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:uck2_human(display_long)|uniprotkb:Uridine monophosphokinase 2(gene name synonym)|uniprotkb:Cytidine monophosphokinase 2(gene name synonym)|uniprotkb:UCK2(gene name)|psi-mi:UCK2(display_short)|uniprotkb:Testis-specific protein TSA903(gene name synonym)|uniprotkb:UMPK(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036606.2|ensembl:ENSG00000143179(gene)|ensembl:ENST00000367879(transcript)|go:"GO:0004849"(uridine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044206"(UMP salvage)|go:"GO:0044211"(CTP salvage)|interpro:IPR000764(Uridine kinase)|interpro:IPR006083(Phosphoribulokinase/uridine kinase)|interpro:IPR027417|interpro:IPR029925|rcsb pdb:1UDW|rcsb pdb:1UEI|rcsb pdb:1UEJ|rcsb pdb:1UFQ|rcsb pdb:1UJ2|rcsb pdb:1XRJ|rcsb pdb:6N53|rcsb pdb:6N54|rcsb pdb:6N55|rcsb pdb:6PWZ|reactome:R-HSA-73614	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rk530GVV4ltYepCzVu5qVMYv5uI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46781	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351206|uniprotkb:Q4QRK7|uniprotkb:Q9BVZ0|ensembl:ENSP00000302896|ensembl:ENSP00000375632|ensembl:ENSP00000375633|ensembl:ENSP00000478449|ensembl:ENSP00000479917|ensembl:ENSP00000480135|ensembl:ENSP00000480662|ensembl:ENSP00000481194|ensembl:ENSP00000481553|ensembl:ENSP00000481655|ensembl:ENSP00000481764|ensembl:ENSP00000481822|ensembl:ENSP00000482023|ensembl:ENSP00000482274|ensembl:ENSP00000482338|ensembl:ENSP00000482475|ensembl:ENSP00000483179|ensembl:ENSP00000484394|uniprotkb:A9C4C1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs9_human(display_long)|uniprotkb:RPS9(gene name)|psi-mi:RPS9(display_short)|uniprotkb:Small ribosomal subunit protein uS4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001004.2|refseq:NP_001308630.1|refseq:NP_001308631.1|refseq:NP_001308633.1|ensembl:ENSG00000170889(gene)|ensembl:ENSG00000274005(gene)|ensembl:ENSG00000274626(gene)|ensembl:ENSG00000274646(gene)|ensembl:ENSG00000274950(gene)|ensembl:ENSG00000275323(gene)|ensembl:ENSG00000277079(gene)|ensembl:ENSG00000277359(gene)|ensembl:ENSG00000278081(gene)|ensembl:ENSG00000278270(gene)|ensembl:ENST00000302907(transcript)|ensembl:ENST00000391752(transcript)|ensembl:ENST00000391753(transcript)|ensembl:ENST00000610826(transcript)|ensembl:ENST00000610953(transcript)|ensembl:ENST00000611921(transcript)|ensembl:ENST00000614737(transcript)|ensembl:ENST00000615346(transcript)|ensembl:ENST00000616082(transcript)|ensembl:ENST00000616536(transcript)|ensembl:ENST00000616839(transcript)|ensembl:ENST00000616877(transcript)|ensembl:ENST00000616928(transcript)|ensembl:ENST00000617291(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000618751(transcript)|go:"GO:0005829"(cytosol)|ensembl:ENST00000619229(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|ensembl:ENST00000620720(transcript)|ensembl:ENST00000620940(transcript)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR001912(Ribosomal protein S4)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005710(Ribosomal protein S4/S9, eukaryotic/archaeal)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|interpro:IPR018079|interpro:IPR022801|interpro:IPR036986|mint:P46781|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|go:"GO:0005634"(nucleus)|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|go:"GO:0005654"(nucleoplasm)|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PGNjkKMs8bMMOSOz2AQvwuCvO1A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07900-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190772|ensembl:ENSP00000335153	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p07900-2(display_long)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym)|uniprotkb:HSP90AA1-2(isoform synonym)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000080824(gene)|ensembl:ENST00000334701(transcript)|intact:EBI-296047(isoform-parent)|uniprotkb:P07900-2(isoform-parent)	-	-	isoform-comment:"Variant in position: 71:M->L (in dbSNP:rs8005905)."	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zSFsoTnWMCxMgg5CMgkY21uBpb89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75955	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BWF3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2856454|uniprotkb:B3KUN0|uniprotkb:Q8WU85|uniprotkb:Q6P1P2|uniprotkb:O02916|uniprotkb:Q4VC48|uniprotkb:B4E1U0|uniprotkb:E7EQS3|ensembl:ENSP00000309166|ensembl:ENSP00000386561|ensembl:ENSP00000386894	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm4_human(display_long)|uniprotkb:RBM4(gene name)|psi-mi:RBM4(display_short)|uniprotkb:RBM4A(gene name synonym)|uniprotkb:Lark homolog(gene name synonym)|uniprotkb:RNA-binding motif protein 4(gene name synonym)|uniprotkb:RNA-binding motif protein 4a(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001185772.1|refseq:NP_002887.2|refseq:NP_001185773.1|dip:DIP-44199N|ensembl:ENSG00000173933(gene)|ensembl:ENST00000310092(transcript)|ensembl:ENST00000408993(transcript)|ensembl:ENST00000409406(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002190"(cap-independent translational initiation)|go:"GO:0002192"(IRES-dependent translational initiation of linear mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0097158"(pre-mRNA intronic pyrimidine-rich binding)|go:"GO:0097167"(circadian regulation of translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR034897|interpro:IPR034898|interpro:IPR035979|mint:Q9BWF3|rcsb pdb:2DNQ|reactome:R-HSA-400253|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hbW6dv/AEWQz3mWvA2/9n8h/bbA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99613	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16695	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9ULV4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351384|uniprotkb:Q9NSK5|uniprotkb:B3KU12|ensembl:ENSP00000261401|ensembl:ENSP00000438341|intact:EBI-4404698|uniprotkb:A7MAP0|uniprotkb:A7MAP1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cor1c_human(display_long)|uniprotkb:CORO1C(gene name)|psi-mi:CORO1C(display_short)|uniprotkb:CRNN4(gene name synonym)|uniprotkb:Coronin-3(gene name synonym)|uniprotkb:hCRNN4(gene name synonym)|uniprotkb:CRN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001263400.1|refseq:NP_055140.1|ensembl:ENSG00000110880(gene)|ensembl:ENST00000261401(transcript)|ensembl:ENST00000541050(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0090148"(membrane fission)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0016197"(endosomal transport)|go:"GO:0097750"(endosome membrane tubulation)|go:"GO:0140285"(endosome fission)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027333|interpro:IPR036322|mint:Q9ULV4|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|refseq:NP_001098707.1|refseq:XP_016874610.1|refseq:XP_016874611.1|refseq:XP_016874612.1|dip:DIP-33138N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Em/LQxjBk9n4tobk5ksyDfFSyeU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62888	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353116|uniprotkb:P04645|uniprotkb:Q502Z6|ensembl:ENSP00000287038|ensembl:ENSP00000428085|uniprotkb:B2R591	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl30_human(display_long)|uniprotkb:RPL30(gene name)|psi-mi:RPL30(display_short)|uniprotkb:Large ribosomal subunit protein eL30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000156482(gene)|ensembl:ENST00000287038(transcript)|ensembl:ENST00000521291(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000231(Ribosomal protein L30e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR022991|interpro:IPR029064|interpro:IPR039109|mint:P62888|rcsb pdb:3VI6|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000980.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xR9LwYg6N7m9njT1pYumOPKZVu49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P00491	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712238|ensembl:ENSP00000354532|uniprotkb:Q15160|uniprotkb:Q5PZ03|uniprotkb:B2R8S5|uniprotkb:D3DS00	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pnph_human(display_long)|uniprotkb:Inosine phosphorylase(gene name synonym)|uniprotkb:PNP(gene name)|psi-mi:PNP(display_short)|uniprotkb:NP(gene name synonym)|uniprotkb:Inosine-guanosine phosphorylase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001882"(nucleoside binding)|go:"GO:0002060"(purine nucleobase binding)|go:"GO:0004731"(purine-nucleoside phosphorylase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006148"(inosine catabolic process)|go:"GO:0006149"(deoxyinosine catabolic process)|go:"GO:0006157"(deoxyadenosine catabolic process)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006204"(IMP catabolic process)|go:"GO:0006738"(nicotinamide riboside catabolic process)|go:"GO:0006955"(immune response)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0019428"(allantoin biosynthetic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043101"(purine-containing compound salvage)|go:"GO:0046059"(dAMP catabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0047975"(guanosine phosphorylase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000845(Nucleoside phosphorylase)|interpro:IPR011268(Inosine guanosine and xanthosine phosphorylase)|interpro:IPR011270(Purine nucleoside phosphorylase I, inosine and guanosine-specific)|interpro:IPR018099|interpro:IPR035994|mint:P00491|rcsb pdb:1M73|rcsb pdb:1PF7|rcsb pdb:1PWY|rcsb pdb:1RCT|rcsb pdb:1RFG|rcsb pdb:1RR6|rcsb pdb:1RSZ|rcsb pdb:1RT9|rcsb pdb:1ULA|rcsb pdb:1ULB|rcsb pdb:1V2H|rcsb pdb:1V3Q|rcsb pdb:1V41|rcsb pdb:1V45|rcsb pdb:1YRY|rcsb pdb:2A0W|rcsb pdb:2A0X|rcsb pdb:2A0Y|rcsb pdb:2OC4|rcsb pdb:2OC9|rcsb pdb:2ON6|rcsb pdb:2Q7O|rcsb pdb:3BGS|rcsb pdb:3D1V|rcsb pdb:3GB9|rcsb pdb:3GGS|ensembl:ENSG00000198805(gene)|ensembl:ENST00000361505(transcript)|go:"GO:0000255"(allantoin metabolic process)|rcsb pdb:3K8O|rcsb pdb:3K8Q|rcsb pdb:3PHB|rcsb pdb:4EAR|rcsb pdb:3INY|rcsb pdb:4EB8|rcsb pdb:4ECE|rcsb pdb:4GKA|rcsb pdb:5ETJ|rcsb pdb:5UGF|reactome:R-HSA-6798695|reactome:R-HSA-74217|reactome:R-HSA-74259|refseq:NP_000261.2|dip:DIP-50406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FOpaxV/M6HIA+THugPZDfN1ej1o9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05388	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354101|uniprotkb:Q9BVK4|intact:EBI-8012155|intact:MINT-8395053|uniprotkb:Q3B7A4|ensembl:ENSP00000339027|ensembl:ENSP00000376299|ensembl:ENSP00000449328	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rla0_human(display_long)|uniprotkb:RPLP0(gene name)|psi-mi:RPLP0(display_short)|uniprotkb:60S ribosomal protein L10E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000993.1|refseq:NP_444505.1|ensembl:ENSG00000089157(gene)|ensembl:ENST00000228306(transcript)|ensembl:ENST00000392514(transcript)|ensembl:ENST00000551150(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0098794"(postsynapse)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR030670|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:P05388|rcsb pdb:4V6W|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8950505|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xv3QHqnXxvCd3BOIeHVkqEnSNNk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43707	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351526|uniprotkb:O76048|uniprotkb:D6PXK4|ensembl:ENSP00000252699|ensembl:ENSP00000489220|uniprotkb:A4K467	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:actn4_human(display_long)|uniprotkb:ACTN4(gene name)|psi-mi:ACTN4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004915.2|ensembl:ENSG00000130402(gene)|ensembl:ENSG00000282844(gene)|ensembl:ENST00000252699(transcript)|ensembl:ENST00000634960(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:O43707|rcsb pdb:1WLX|rcsb pdb:1YDI|rcsb pdb:2R0O|rcsb pdb:6O31|rcsb pdb:6OA6|reactome:R-HSA-114608|reactome:R-HSA-373753|dip:DIP-33179N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kTYezA2lEtL/AQPfCQ8BE79nzow9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00299	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347404|uniprotkb:Q15089|uniprotkb:Q502X1|ensembl:ENSP00000404037|ensembl:ENSP00000404589|ensembl:ENSP00000406088|ensembl:ENSP00000406335|ensembl:ENSP00000406968|ensembl:ENSP00000407429|ensembl:ENSP00000407791|ensembl:ENSP00000408094|ensembl:ENSP00000408357|ensembl:ENSP00000409247|ensembl:ENSP00000409979|ensembl:ENSP00000410965|ensembl:ENSP00000412217|ensembl:ENSP00000413330|ensembl:ENSP00000416211|ensembl:ENSP00000477623|ensembl:ENSP00000478930|ensembl:ENSP00000479501|ensembl:ENSP00000479808|ensembl:ENSP00000480256|ensembl:ENSP00000482255|ensembl:ENSP00000484581|ensembl:ENSP00000364934|ensembl:ENSP00000364935|ensembl:ENSP00000364940|ensembl:ENSP00000372896|ensembl:ENSP00000372897|ensembl:ENSP00000379229|ensembl:ENSP00000382926|ensembl:ENSP00000382931|ensembl:ENSP00000391395|ensembl:ENSP00000398056|ensembl:ENSP00000400280|ensembl:ENSP00000400532|ensembl:ENSP00000401292	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clic1_human(display_long)|uniprotkb:CLIC1(gene name)|psi-mi:CLIC1(display_short)|uniprotkb:NCC27(gene name synonym)|uniprotkb:Nuclear chloride ion channel 27(gene name synonym)|uniprotkb:Chloride channel ABP(gene name synonym)|uniprotkb:Regulatory nuclear chloride ion channel protein(gene name synonym)|uniprotkb:G6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001279.2|refseq:NP_001274522.1|refseq:NP_001274523.1|ensembl:ENST00000375779(transcript)|ensembl:ENST00000375780(transcript)|ensembl:ENST00000375784(transcript)|ensembl:ENST00000383404(transcript)|ensembl:ENST00000383405(transcript)|ensembl:ENST00000395892(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006821"(chloride transport)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030259|go:"GO:0005634"(nucleus)|ensembl:ENSG00000206394(gene)|ensembl:ENSG00000213719(gene)|ensembl:ENSG00000223639(gene)|ensembl:ENSG00000226248(gene)|ensembl:ENSG00000226417(gene)|ensembl:ENSG00000226651(gene)|ensembl:ENSG00000230685(gene)|ensembl:ENST00000400052(transcript)|ensembl:ENST00000400058(transcript)|ensembl:ENST00000415179(transcript)|ensembl:ENST00000418285(transcript)|ensembl:ENST00000420458(transcript)|ensembl:ENST00000422167(transcript)|ensembl:ENST00000423055(transcript)|ensembl:ENST00000423143(transcript)|ensembl:ENST00000423804(transcript)|ensembl:ENST00000425464(transcript)|ensembl:ENST00000431921(transcript)|ensembl:ENST00000433916(transcript)|ensembl:ENST00000434202(transcript)|ensembl:ENST00000435242(transcript)|ensembl:ENST00000438708(transcript)|ensembl:ENST00000438750(transcript)|ensembl:ENST00000442045(transcript)|ensembl:ENST00000447338(transcript)|ensembl:ENST00000447369(transcript)|ensembl:ENST00000451546(transcript)|ensembl:ENST00000456863(transcript)|ensembl:ENST00000457485(transcript)|ensembl:ENST00000614673(transcript)|ensembl:ENST00000614982(transcript)|ensembl:ENST00000616760(transcript)|ensembl:ENST00000618288(transcript)|ensembl:ENST00000619727(transcript)|ensembl:ENST00000621055(transcript)|ensembl:ENST00000622613(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005615"(extracellular space)|interpro:IPR036282|interpro:IPR040079|mint:O00299|interpro:IPR036249|rcsb pdb:1K0M|rcsb pdb:1K0N|rcsb pdb:1K0O|rcsb pdb:1RK4|rcsb pdb:3O3T|rcsb pdb:3P8W|rcsb pdb:3P90|rcsb pdb:3QR6|rcsb pdb:3SWL|rcsb pdb:3TGZ|rcsb pdb:3UVH|rcsb pdb:4IQA|rcsb pdb:4JZQ|rcsb pdb:4K0G|rcsb pdb:4K0N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HVux62IcNdqcPgqmlGlIyZTLpFo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26640	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355765|uniprotkb:Q5JQ90|uniprotkb:Q96E77|uniprotkb:Q9UQM2|uniprotkb:B4DZ61|uniprotkb:B0V1N1|ensembl:ENSP00000211402|ensembl:ENSP00000364815|ensembl:ENSP00000401121|ensembl:ENSP00000403359|ensembl:ENSP00000415316	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syvc_human(display_long)|uniprotkb:VARS1(gene name)|psi-mi:VARS1(display_short)|uniprotkb:G7A(gene name synonym)|uniprotkb:Protein G7a(gene name synonym)|uniprotkb:VARS(gene name synonym)|uniprotkb:VARS2(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006286.1|ensembl:ENSG00000096171(gene)|ensembl:ENSG00000204394(gene)|ensembl:ENSG00000224264(gene)|ensembl:ENSG00000226589(gene)|ensembl:ENSG00000231116(gene)|ensembl:ENST00000211402(transcript)|ensembl:ENST00000375663(transcript)|ensembl:ENST00000422694(transcript)|ensembl:ENST00000435657(transcript)|ensembl:ENST00000457796(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|interpro:IPR036282|interpro:IPR037118|mint:P26640|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aPfpK0/C2KpCsMOI0sjCreufI509606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13010	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60866	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353105|uniprotkb:P17075|uniprotkb:Q5M8S9|uniprotkb:B2R4F4|uniprotkb:B4DW28|ensembl:ENSP00000009589|ensembl:ENSP00000427788|ensembl:ENSP00000503327|ensembl:ENSP00000504123|ensembl:ENSP00000504154|ensembl:ENSP00000504670	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs20_human(display_long)|uniprotkb:RPS20(gene name)|psi-mi:RPS20(display_short)|uniprotkb:Small ribosomal subunit protein uS10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001014.1|refseq:NP_001139699.1|dip:DIP-31245N|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|ensembl:ENSG00000008988(gene)|ensembl:ENST00000009589(transcript)|ensembl:ENST00000521262(transcript)|ensembl:ENST00000676461(transcript)|ensembl:ENST00000676918(transcript)|ensembl:ENST00000678039(transcript)|ensembl:ENST00000678683(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR001848(Ribosomal protein S10)|interpro:IPR005729(Ribosomal protein S10, eukaryotic/archaeal)|interpro:IPR018268|interpro:IPR027486|interpro:IPR036838|mint:P60866|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6xNxX+eP59AOm0KraCysRHUqMFw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50552	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13185	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78176|ensembl:ENSP00000336687|ensembl:ENSP00000379670|uniprotkb:Q96CD7|uniprotkb:Q99409|uniprotkb:Q9BVS3|uniprotkb:Q9P0Z6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cbx3_human(display_long)|uniprotkb:CBX3(gene name)|psi-mi:CBX3(display_short)|uniprotkb:Heterochromatin protein 1 homolog gamma(gene name synonym)|uniprotkb:Modifier 2 protein(gene name synonym)|uniprotkb:HECH(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|ensembl:ENSG00000122565(gene)|ensembl:ENST00000337620(transcript)|ensembl:ENST00000396386(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR038033|mint:Q13185|rcsb pdb:2L11|rcsb pdb:3DM1|rcsb pdb:3KUP|rcsb pdb:3TZD|go:"GO:0005637"(nuclear inner membrane)|rcsb pdb:6HW2|reactome:R-HSA-427389|reactome:R-HSA-73772|reactome:R-HSA-8953750|rcsb pdb:5T1I|refseq:NP_009207.2|refseq:NP_057671.2|refseq:XP_005249668.1|dip:DIP-5985N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6L5OQHfxCBkmPV5Z0XihmXx4mFQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04792	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42285	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347612|uniprotkb:Q2M386|uniprotkb:Q6MZZ8|uniprotkb:Q6P170|uniprotkb:Q8N5R0|uniprotkb:Q8TAG2|ensembl:ENSP00000230640	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mtrex_human(display_long)|uniprotkb:MTREX(gene name)|psi-mi:MTREX(display_short)|uniprotkb:DOB1(gene name synonym)|uniprotkb:KIAA0052(gene name synonym)|uniprotkb:MTR4(gene name synonym)|uniprotkb:SKIV2L2(gene name synonym)|uniprotkb:Superkiller viralicidic activity 2-like 2(gene name synonym)|uniprotkb:TRAMP-like complex helicase(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DOB1(gene name synonym)|uniprotkb:ATP-dependent RNA helicase SKIV2L2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056175.3|ensembl:ENSG00000039123(gene)|ensembl:ENST00000230640(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016076"(snRNA catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0031499"(TRAMP complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|mint:P42285|rcsb pdb:6C90|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6IEG|rcsb pdb:6IEH|rcsb pdb:6RO1|reactome:R-HSA-6791226|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bQdFDddFhetSp+CJ1S7Q5cm+g0k9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50990	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356507|uniprotkb:A6NN54|uniprotkb:Q4VBP8|uniprotkb:B4DEM7|uniprotkb:B4DQH4|ensembl:ENSP00000286788	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpq_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:CCTQ(gene name synonym)|uniprotkb:KIAA0002(gene name synonym)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-15(gene name synonym)|uniprotkb:C21orf112(gene name synonym)|uniprotkb:Chaperonin containing T-complex polypeptide 1 subunit 8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001269836.1|refseq:NP_001269838.1|refseq:NP_006576.2|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50990|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|ensembl:ENSG00000156261(gene)|ensembl:ENST00000286788(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016887"(ATP hydrolysis activity)|reactome:R-HSA-6798695|reactome:R-HSA-6814122|reactome:R-HSA-5620922|dip:DIP-38124N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/TlB7Gk2Z9GPvfV3JBE0nWUF34Y9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6B6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4290665|uniprotkb:D3DQA4|uniprotkb:Q567T4|ensembl:ENSP00000385432|ensembl:ENSP00000404997	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sar1b_human(display_long)|uniprotkb:SAR1B(gene name)|psi-mi:SAR1B(display_short)|uniprotkb:SARA2(gene name synonym)|uniprotkb:SARB(gene name synonym)|uniprotkb:GTP-binding protein B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000152700(gene)|ensembl:ENST00000402673(transcript)|ensembl:ENST00000439578(transcript)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0061024"(membrane organization)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006687(GTP-binding protein SAR1)|interpro:IPR006689(ARF/SAR superfamily)|go:"GO:0003400"(regulation of COPII vesicle coating)|interpro:IPR027417|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-5694530|reactome:R-HSA-8963888|reactome:R-HSA-983170|reactome:R-HSA-1655829|refseq:NP_001028675.1|refseq:NP_057187.1|refseq:XP_016865010.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Tq+D9CeccMteZSbthpVFFBuazjY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BUF5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55072	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49588	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709710|uniprotkb:A6NF14|uniprotkb:Q53GV7|uniprotkb:Q96FA0|uniprotkb:B4DR45|ensembl:ENSP00000261772|ensembl:ENSP00000501924|ensembl:ENSP00000502247|ensembl:ENSP00000502797	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syac_human(display_long)|uniprotkb:AARS1(gene name)|psi-mi:AARS1(display_short)|uniprotkb:AARS(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-42(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001596.2|ensembl:ENSG00000090861(gene)|ensembl:ENST00000261772(transcript)|ensembl:ENST00000674691(transcript)|ensembl:ENST00000674963(transcript)|ensembl:ENST00000675643(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016597"(amino acid binding)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140018"(regulation of cytoplasmic translational fidelity)|interpro:IPR002318(Alanyl-tRNA synthetase, class IIc)|interpro:IPR003156(Phosphoesterase, DHHA1)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018162|interpro:IPR018163|interpro:IPR018164|interpro:IPR018165|interpro:IPR023033|mint:P49588|rcsb pdb:4XEM|rcsb pdb:4XEO|rcsb pdb:5KNN|rcsb pdb:5T5S|rcsb pdb:5T76|rcsb pdb:5V59|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e9+gLroLXvK8li0wiPBGbZhQqP49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12956	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NP79	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-740160|uniprotkb:Q5TGM1|uniprotkb:Q6IAE8|uniprotkb:Q9H0R2|uniprotkb:Q9H3K9|uniprotkb:Q9P0Q0|uniprotkb:E1P594|ensembl:ENSP00000356602|uniprotkb:B4DW55|uniprotkb:E7ETQ7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vta1_human(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:HSPC228(orf name)|uniprotkb:My012(orf name)|uniprotkb:SKD1-binding protein 1(gene name synonym)|uniprotkb:C6orf55(gene name synonym)|uniprotkb:Dopamine-responsive gene 1 protein(gene name synonym)|uniprotkb:LYST-interacting protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001273300.1|refseq:NP_001273301.1|refseq:NP_057569.2|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:4U7E|reactome:R-HSA-162588|reactome:R-HSA-917729|ensembl:ENSG00000009844(gene)|ensembl:ENST00000367630(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LXL|rcsb pdb:2LXM|rcsb pdb:4TXP	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QIeYrvtJGJ2jWli8PWK9TeO6gus9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-443446|ensembl:ENSP00000341885|uniprotkb:Q3MIB1|uniprotkb:B2R5G0|uniprotkb:D3DU82	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs2_human(display_long)|uniprotkb:RPS2(gene name)|psi-mi:RPS2(display_short)|uniprotkb:RPS4(gene name synonym)|uniprotkb:40S ribosomal protein S4(gene name synonym)|uniprotkb:Protein LLRep3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|rcsb pdb:6OLG|rcsb pdb:6OLI|interpro:IPR018192|rcsb pdb:6OLZ|interpro:IPR020568|mint:P15880|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6EK0|rcsb pdb:6G18|rcsb pdb:6XA1|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6G5H|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7JQB|rcsb pdb:7JQC|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-3214858|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8876725|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:7A09|ensembl:ENSG00000140988(gene)|ensembl:ENST00000343262(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045296"(cadherin binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000851(Ribosomal protein S5)|interpro:IPR005324(Ribosomal protein S5, C-terminal)|interpro:IPR005711(Ribosomal protein S5, eukaryotic/archaeal)|interpro:IPR013810(Ribosomal protein S5, N-terminal)|refseq:NP_002943.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JUr2Y3cGk00S8KaTVPymshfaHhc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60264	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352588|ensembl:ENSP00000283131	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smca5_human(display_long)|uniprotkb:SMARCA5(gene name)|psi-mi:SMARCA5(display_short)|uniprotkb:SNF2H(gene name synonym)|uniprotkb:WCRF135(gene name synonym)|uniprotkb:Sucrose nonfermenting protein 2 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000283131(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016589"(NURF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031213"(RSF complex)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015194(Nucleosome remodelling ATPase ISWI, HAND)|interpro:IPR015195(SLIDE)|interpro:IPR017884|interpro:IPR027417|interpro:IPR036306|interpro:IPR038718|mint:O60264|rcsb pdb:6NE3|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5693565|reactome:R-HSA-606279|refseq:NP_003592.3|ensembl:ENSG00000153147(gene)|dip:DIP-33204N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XlXL5MRhAFlqHhGroPdm01lYEk89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00610	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08238	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wOsW7C10v2oMsM+REE38K6PAan09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40227	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356687|uniprotkb:Q3KP28|uniprotkb:Q75LP4|uniprotkb:Q96S46|ensembl:ENSP00000275603|intact:EBI-5912031|uniprotkb:A6NCD2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpz_human(display_long)|uniprotkb:CCT6A(gene name)|psi-mi:CCT6A(display_short)|uniprotkb:CCT6(gene name synonym)|uniprotkb:CCTZ(gene name synonym)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Tcp20(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Acute morphine dependence-related protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001753.1|ensembl:ENSG00000146731(gene)|ensembl:ENST00000275603(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P40227|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|refseq:NP_001009186.1|dip:DIP-33558N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kX6/rTGZbGuVLNgBW6IxdNlU46U9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62826	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92973	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286693|intact:EBI-1760498|uniprotkb:Q92957|uniprotkb:Q92975|intact:EBI-1965561|uniprotkb:B4DVC6|ensembl:ENSP00000336712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tnpo1_human(display_long)|uniprotkb:TRN(gene name synonym)|uniprotkb:TNPO1(gene name)|psi-mi:TNPO1(display_short)|uniprotkb:KPNB2(gene name synonym)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Importin beta-2(gene name synonym)|uniprotkb:Karyopherin beta-2(gene name synonym)|uniprotkb:M9 region interaction protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002261.3|refseq:NP_694858.1|refseq:XP_005248557.1|dip:DIP-29335N|ensembl:ENSG00000083312(gene)|ensembl:ENST00000337273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q92973|rcsb pdb:1QBK|rcsb pdb:2H4M|rcsb pdb:2OT8|rcsb pdb:2QMR|rcsb pdb:2Z5J|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:2Z5N|rcsb pdb:2Z5O|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:4JLQ|rcsb pdb:4OO6|rcsb pdb:5J3V|rcsb pdb:5TQC|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:7CYL|reactome:R-HSA-450513|reactome:R-HSA-5620924|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n8Q3n1rmTiJAp6f8DBcBV6j6lac9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43488	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748855|uniprotkb:O75749|uniprotkb:Q5TG63|ensembl:ENSP00000235835	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ark72_human(display_long)|uniprotkb:AFB1 aldehyde reductase 1(gene name synonym)|uniprotkb:Aldoketoreductase 7(gene name synonym)|uniprotkb:AKR7A2(gene name)|psi-mi:AKR7A2(display_short)|uniprotkb:AFAR(gene name synonym)|uniprotkb:AFAR1(gene name synonym)|uniprotkb:AKR7(gene name synonym)|uniprotkb:Succinic semialdehyde reductase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003680.2|ensembl:ENSG00000053371(gene)|ensembl:ENST00000235835(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0019119"(phenanthrene-9,10-epoxide hydrolase activity)|go:"GO:0044597"(daunorubicin metabolic process)|go:"GO:0044598"(doxorubicin metabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR023210|interpro:IPR036812|rcsb pdb:2BP1|reactome:R-HSA-5423646	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HUJHFlZOl/Xb03VzAZAcmsEHK9o9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:H0YHG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190012|ensembl:ENSP00000447000	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h0yhg0_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000257390(gene)|ensembl:ENST00000546837(transcript)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR032843|interpro:IPR036361|interpro:IPR036869	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Rb4NKPkoUZDm37vByGa9J2Vlbm09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P37802	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056740|intact:EBI-2825986|uniprotkb:Q5JRQ6|uniprotkb:Q5JRQ7|uniprotkb:Q9BUH5|uniprotkb:Q9H4P0|uniprotkb:Q6FGI1|uniprotkb:E9KL39|ensembl:ENSP00000357075|ensembl:ENSP00000357077	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tagl2_human(display_long)|uniprotkb:TAGLN2(gene name)|psi-mi:TAGLN2(display_short)|uniprotkb:KIAA0120(gene name synonym)|uniprotkb:SM22-alpha homolog(gene name synonym)|uniprotkb:CDABP0035(orf name)|uniprotkb:Epididymis tissue protein Li 7e(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003555.1|refseq:NP_001264152.1|refseq:NP_001264153.1|ensembl:ENSG00000158710(gene)|ensembl:ENST00000320307(transcript)|ensembl:ENST00000368097(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000557(Calponin repeat)|interpro:IPR001061("Transgelin (SM22-alpha)")|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|mint:P37802|rcsb pdb:1WYM|reactome:R-HSA-114608	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxbMK5SbZWQd+XA9iYc/xuNaVQc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62857	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353027|ensembl:ENSP00000472469|uniprotkb:P25112	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs28_human(display_long)|uniprotkb:RPS28(gene name)|psi-mi:RPS28(display_short)|uniprotkb:Small ribosomal subunit protein eS28(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	mint:P62857|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|ensembl:ENSG00000233927(gene)|ensembl:ENST00000600659(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR000289(Ribosomal protein S28e)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028626|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZM7|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001022.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G4t8mOlzIiHEOXu+uS+AfySWAnM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10412	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358163|uniprotkb:Q4VB25|ensembl:ENSP00000307705	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h14_human(display_long)|uniprotkb:H1-4(gene name)|psi-mi:H1-4(display_short)|uniprotkb:H1F4(gene name synonym)|uniprotkb:HIST1H1E(gene name synonym)|uniprotkb:Histone H1b(gene name synonym)|uniprotkb:Histone H1s-4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005312.1|rcsb pdb:6H8P|rcsb pdb:7K5Y|rcsb pdb:7K63|go:"GO:0032564"(dATP binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P10412|rcsb pdb:3TZD|rcsb pdb:5JJZ|reactome:R-HSA-140342|reactome:R-HSA-2559584|ensembl:ENSG00000168298(gene)|ensembl:ENST00000304218(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000792"(heterochromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016208"(AMP binding)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yT8wBbspLLR8G3DrgpFeWEOPgac9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43633	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2692789|uniprotkb:B2R4W6|uniprotkb:Q3ZTT0|ensembl:ENSP00000310440|ensembl:ENSP00000469240|ensembl:ENSP00000472680	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:chm2a_human(display_long)|uniprotkb:BC2(gene name synonym)|uniprotkb:CHMP2(gene name synonym)|uniprotkb:Chromatin-modifying protein 2a(gene name synonym)|uniprotkb:Putative breast adenocarcinoma marker BC-2(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-1(gene name synonym)|uniprotkb:CHMP2A(gene name)|psi-mi:CHMP2A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055268.1|refseq:NP_940818.1|ensembl:ENSG00000130724(gene)|ensembl:ENST00000312547(transcript)|ensembl:ENST00000600118(transcript)|ensembl:ENST00000601220(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010324"(membrane invagination)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:O43633|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-432720|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-48533N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:S5uZThg//3igYMf6LLYDJ/FVGRA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7KZF4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044112|uniprotkb:Q13122|ensembl:ENSP00000346762|uniprotkb:Q96AG0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snd1_human(display_long)|uniprotkb:100 kDa coactivator(gene name synonym)|uniprotkb:EBNA2 coactivator p100(gene name synonym)|uniprotkb:Tudor domain-containing protein 11(gene name synonym)|uniprotkb:SND1(gene name)|psi-mi:SND1(display_short)|uniprotkb:p100 co-activator(gene name synonym)|uniprotkb:TDRD11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055205.2|ensembl:ENSG00000197157(gene)|ensembl:ENST00000354725(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0042470"(melanosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097433"(dense body)|go:"GO:1905172"(RISC complex binding)|interpro:IPR002071(Thermonuclease active site)|interpro:IPR002999(Tudor)|interpro:IPR016071("Staphylococcal nuclease (SNase-like), OB-fold")|interpro:IPR016685(RNA-induced silencing complex, nuclease component Tudor-SN)|interpro:IPR035437|mint:Q7KZF4|rcsb pdb:2E6N|rcsb pdb:2HQE|rcsb pdb:2HQX|rcsb pdb:2O4X|rcsb pdb:3BDL|rcsb pdb:3OMC|rcsb pdb:3OMG|rcsb pdb:4QMG|rcsb pdb:5M9O|reactome:R-HSA-6802952|dip:DIP-29613N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I9JNlRfASs5dwk0JZQ+F+GsW94g9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P16949	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-445909|uniprotkb:A2A2D1|uniprotkb:B7Z8N4|uniprotkb:D3DPJ5|uniprotkb:B2R4E7|ensembl:ENSP00000350531|ensembl:ENSP00000363409|ensembl:ENSP00000382633|ensembl:ENSP00000387858	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stmn1_human(display_long)|uniprotkb:Phosphoprotein p19(gene name synonym)|uniprotkb:Leukemia-associated phosphoprotein p18(gene name synonym)|uniprotkb:Oncoprotein 18(gene name synonym)|uniprotkb:pp17(gene name synonym)|uniprotkb:Prosolin(gene name synonym)|uniprotkb:Metablastin(gene name synonym)|uniprotkb:Protein Pr22(gene name synonym)|uniprotkb:STMN1(gene name)|psi-mi:STMN1(display_short)|uniprotkb:LAP18(gene name synonym)|uniprotkb:OP18(gene name synonym)|uniprotkb:C1orf215(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138926.1|refseq:NP_005554.1|refseq:NP_981944.1|refseq:NP_981946.1|ensembl:ENST00000357865(transcript)|ensembl:ENST00000374291(transcript)|ensembl:ENST00000399728(transcript)|ensembl:ENST00000455785(transcript)|go:"GO:0000281"(mitotic cytokinesis)|ensembl:ENSG00000117632(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|mint:P16949|interpro:IPR000956(Stathmin)|interpro:IPR030514|interpro:IPR036002|reactome:R-HSA-1251985	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gew+NqUuLLolCLCXOyXIZkRieIs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02100	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190240|ensembl:ENSP00000292896|ensembl:ENSP00000369586|ensembl:ENSP00000380104|uniprotkb:Q6FH44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbe_human(display_long)|uniprotkb:HBE1(gene name)|psi-mi:HBE1(display_short)|uniprotkb:HBE(gene name synonym)|uniprotkb:Epsilon-globin(gene name synonym)|uniprotkb:Hemoglobin epsilon chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000213931(gene)|ensembl:ENST00000292896(transcript)|ensembl:ENST00000380237(transcript)|ensembl:ENST00000396895(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1A9W|reactome:R-HSA-983231|refseq:NP_005321.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZKgpsS0AFjNRaxSJ4ctde2ESHik9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08670	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4E386	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189985	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4e386_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|refseq:NP_001290458.1|refseq:NP_001290459.1|interpro:IPR023123|interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|interpro:IPR037103	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:prJej5wjji2EkLUy3KTAIdRbnnw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047080|uniprotkb:Q15074|intact:EBI-1171814|uniprotkb:Q6IMN4|uniprotkb:A6NMY7|uniprotkb:Q6IMN7|uniprotkb:Q9BV09|intact:EBI-2562858|intact:EBI-3449178|uniprotkb:D3DR06|ensembl:ENSP00000340329|ensembl:ENSP00000434150	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:capr1_human(display_long)|uniprotkb:CAPRIN1(gene name)|psi-mi:CAPRIN1(display_short)|uniprotkb:GPIAP1(gene name synonym)|uniprotkb:GPIP137(gene name synonym)|uniprotkb:M11S1(gene name synonym)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Cell cycle-associated protein 1(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:RNG105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005889.3|refseq:NP_976240.1|ensembl:ENSG00000135387(gene)|ensembl:ENST00000341394(transcript)|ensembl:ENST00000532820(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q14444|rcsb pdb:4WBE|rcsb pdb:4WBP|rcsb pdb:6TA7|refseq:XP_016873238.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3c6ZdBClP/D6jIi8NfzBkMc61pI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62633	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N5M4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2851213|uniprotkb:Q8WYY7|ensembl:ENSP00000325266|ensembl:ENSP00000434340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ttc9c_human(display_long)|uniprotkb:TTC9C(gene name)|psi-mi:TTC9C(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001305745.1|refseq:NP_776171.1|refseq:NP_001305741.1|refseq:NP_001305742.1|refseq:NP_001305743.1|refseq:NP_001305744.1|ensembl:ENSG00000162222(gene)|ensembl:ENST00000316461(transcript)|ensembl:ENST00000532583(transcript)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IazckGbo0Z5cqr/m7hx7Av7BJlU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P84085	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4289908|uniprotkb:P26437|ensembl:ENSP00000000233	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arf5_human(display_long)|uniprotkb:ARF5(gene name)|psi-mi:ARF5(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000004059(gene)|ensembl:ENST00000000233(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84085|rcsb pdb:2B6H|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001653.1|dip:DIP-61289N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00403	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-389564|uniprotkb:A8K1A7|uniprotkb:Q5JS30|ensembl:ENSP00000359531	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tf2b_human(display_long)|uniprotkb:GTF2B(gene name)|psi-mi:GTF2B(display_short)|uniprotkb:TF2B(gene name synonym)|uniprotkb:TFIIB(gene name synonym)|uniprotkb:General transcription factor TFIIB(gene name synonym)|uniprotkb:S300-II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001505.1|ensembl:ENSG00000137947(gene)|ensembl:ENST00000370500(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001174"(transcriptional start site selection at RNA polymerase II promoter)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005694"(chromosome)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019083"(viral transcription)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990114"(RNA polymerase II core complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000812(Transcription factor TFIIB related)|interpro:IPR013137(Zinc finger, TFIIB-type)|interpro:IPR013150(Transcription factor TFIIB, cyclin-related)|interpro:IPR013763(Cyclin-related)|interpro:IPR023486|interpro:IPR036915|mint:Q00403|rcsb pdb:1C9B|rcsb pdb:1DL6|rcsb pdb:1RLY|rcsb pdb:1RO4|rcsb pdb:1TFB|rcsb pdb:1VOL|rcsb pdb:2PHG|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5WH1|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|dip:DIP-1077N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mVGHi0jBibSFHpBrVTGHnRm4gXw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PAU2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189929|ensembl:ENSP00000482486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pau2_human(display_long)|uniprotkb:RAVER1(gene name)|psi-mi:RAVER1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000611074(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034633|interpro:IPR034635|interpro:IPR035979|ensembl:ENSG00000161847(gene)|refseq:NP_597709.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:R49B14TFxiQLK5QlLBcHyZQTKD09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42677	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356336|ensembl:ENSP00000499044|uniprotkb:Q5T4L6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs27_human(display_long)|uniprotkb:RPS27(gene name)|psi-mi:RPS27(display_short)|uniprotkb:MPS1(gene name synonym)|uniprotkb:Metallopan-stimulin 1(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS27(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001021.1|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000177954(gene)|ensembl:ENST00000651669(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407|mint:P42677|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-141444|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-2500257|rcsb pdb:6OM7|reactome:R-HSA-5663220|reactome:R-HSA-6791226|reactome:R-HSA-68877|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-9648025|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-44182N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OA5IWAJDBpY5FFdVnun7Sq/jI7g9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17096	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746843|uniprotkb:P10910|uniprotkb:Q9UKB0|uniprotkb:Q5T6U9|ensembl:ENSP00000308227|ensembl:ENSP00000399888	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmga1_human(display_long)|uniprotkb:High mobility group AT-hook protein 1(gene name synonym)|uniprotkb:HMGA1(gene name)|psi-mi:HMGA1(display_short)|uniprotkb:HMGIY(gene name synonym)|uniprotkb:High mobility group protein R(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002122.1|refseq:NP_665906.1|refseq:NP_665908.1|refseq:NP_665909.1|refseq:NP_665910.1|refseq:NP_665912.1|refseq:NP_001306006.1|refseq:NP_001306007.1|refseq:NP_001306008.1|refseq:NP_001306009.1|refseq:NP_001306010.1|refseq:NP_001306011.1|ensembl:ENSG00000137309(gene)|ensembl:ENST00000311487(transcript)|ensembl:ENST00000447654(transcript)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030527"(structural constituent of chromatin)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR000116(High mobility group, HMG-I and HMG-Y)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR017956|interpro:IPR031079|mint:P17096|rcsb pdb:2EZD|rcsb pdb:2EZE|rcsb pdb:2EZF|rcsb pdb:2EZG|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|reactome:R-HSA-2559584|dip:DIP-29687N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hhCMZ6CUf3e+PD0RNIauCZ8EThM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-749627|uniprotkb:Q53ZD6|uniprotkb:E1P5N4|ensembl:ENSP00000217402	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:chm4b_human(display_long)|uniprotkb:Chromatin-modifying protein 4b(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 32-2(gene name synonym)|uniprotkb:SNF7-2(gene name synonym)|uniprotkb:SNF7 homolog associated with Alix 1(gene name synonym)|uniprotkb:CHMP4B(gene name)|psi-mi:CHMP4B(display_short)|uniprotkb:C20orf178(gene name synonym)|uniprotkb:SHAX1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_789782.1|dip:DIP-29924N|ensembl:ENSG00000101421(gene)|ensembl:ENST00000217402(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016236"(macroautophagy)|go:"GO:0030117"(membrane coat)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046755"(viral budding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051258"(protein polymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090148"(membrane fission)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR005024(Snf7)|mint:Q9H444|rcsb pdb:3C3Q|rcsb pdb:3UM3|rcsb pdb:4ABM|rcsb pdb:5MK2|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0010824"(regulation of centrosome duplication)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hbJvirD5+L7fxzOoWbiP1ky6c9M9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69905	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714680|uniprotkb:P01922|ensembl:ENSP00000251595|ensembl:ENSP00000322421|uniprotkb:Q3MIF5|uniprotkb:Q96KF1|uniprotkb:Q9NYR7|uniprotkb:Q1HDT5|uniprotkb:Q53F97|uniprotkb:Q9UCM0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hba_human(display_long)|uniprotkb:Hemoglobin alpha chain(gene name synonym)|uniprotkb:Alpha-globin(gene name synonym)|uniprotkb:HBA1(gene name)|psi-mi:HBA1(display_short)|uniprotkb:HBA2(gene name)|psi-mi:HBA2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000188536(gene)|ensembl:ENSG00000206172(gene)|ensembl:ENST00000251595(transcript)|ensembl:ENST00000320868(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015671"(oxygen transport)|go:"GO:0016020"(membrane)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002339(Haemoglobin, pi)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|mint:P69905|rcsb pdb:1A00|rcsb pdb:1A01|rcsb pdb:1A0U|rcsb pdb:1A0Z|rcsb pdb:1A3N|rcsb pdb:1A3O|rcsb pdb:1A9W|rcsb pdb:1ABW|rcsb pdb:1ABY|rcsb pdb:1AJ9|rcsb pdb:1B86|rcsb pdb:1BAB|rcsb pdb:1BBB|rcsb pdb:1BIJ|rcsb pdb:1BUW|rcsb pdb:1BZ0|rcsb pdb:1BZ1|rcsb pdb:1BZZ|rcsb pdb:1C7B|rcsb pdb:1C7C|rcsb pdb:1C7D|rcsb pdb:1CLS|rcsb pdb:1CMY|rcsb pdb:1COH|rcsb pdb:1DKE|rcsb pdb:1DXT|rcsb pdb:1DXU|rcsb pdb:1DXV|rcsb pdb:1FDH|rcsb pdb:1FN3|rcsb pdb:1G9V|rcsb pdb:1YVQ|rcsb pdb:1YVT|rcsb pdb:1YZI|rcsb pdb:1Z8U|rcsb pdb:2D5Z|rcsb pdb:2D60|rcsb pdb:2DN1|rcsb pdb:2DN2|rcsb pdb:2DN3|rcsb pdb:2DXM|rcsb pdb:2H35|rcsb pdb:2HBC|rcsb pdb:2HBD|rcsb pdb:2HBE|rcsb pdb:2HBF|rcsb pdb:2HBS|rcsb pdb:2HCO|rcsb pdb:2HHB|rcsb pdb:2HHD|rcsb pdb:2HHE|rcsb pdb:2M6Z|rcsb pdb:2W6V|rcsb pdb:2W72|rcsb pdb:2YRS|rcsb pdb:3B75|rcsb pdb:3D17|rcsb pdb:3D7O|rcsb pdb:3DUT|rcsb pdb:3HHB|rcsb pdb:3HXN|rcsb pdb:3IA3|rcsb pdb:3IC0|rcsb pdb:3IC2|rcsb pdb:3KMF|rcsb pdb:3NL7|rcsb pdb:3NMM|rcsb pdb:3ODQ|rcsb pdb:3ONZ|rcsb pdb:3OO4|rcsb pdb:3OO5|rcsb pdb:3OVU|rcsb pdb:3P5Q|rcsb pdb:3QJB|rcsb pdb:3QJC|rcsb pdb:3QJD|rcsb pdb:3QJE|rcsb pdb:3R5I|rcsb pdb:3S48|rcsb pdb:3S65|rcsb pdb:3S66|rcsb pdb:3SZK|rcsb pdb:3WCP|rcsb pdb:3WHM|rcsb pdb:4FC3|rcsb pdb:4HHB|rcsb pdb:4IJ2|rcsb pdb:4L7Y|rcsb pdb:4M4A|rcsb pdb:4M4B|rcsb pdb:4MQC|rcsb pdb:4MQG|rcsb pdb:4MQH|rcsb pdb:4MQI|rcsb pdb:4MQJ|rcsb pdb:4MQK|rcsb pdb:4X0L|rcsb pdb:4XS0|rcsb pdb:5E29|rcsb pdb:5E6E|rcsb pdb:5E83|rcsb pdb:5EE4|rcsb pdb:5HU6|rcsb pdb:5HY8|rcsb pdb:5JDO|rcsb pdb:5KDQ|rcsb pdb:5KSI|rcsb pdb:5KSJ|rcsb pdb:5NI1|rcsb pdb:5SW7|rcsb pdb:5U3I|rcsb pdb:5UCU|rcsb pdb:5UFJ|rcsb pdb:5URC|rcsb pdb:5VMM|rcsb pdb:5WOG|rcsb pdb:5WOH|rcsb pdb:5X2R|rcsb pdb:5X2S|rcsb pdb:5X2T|rcsb pdb:5X2U|rcsb pdb:6BB5|rcsb pdb:6BNR|rcsb pdb:6BWP|rcsb pdb:6BWU|rcsb pdb:6DI4|rcsb pdb:6HAL|rcsb pdb:6HBW|rcsb pdb:6HK2|rcsb pdb:6KA9|rcsb pdb:6KAE|rcsb pdb:6KAH|rcsb pdb:6KAI|rcsb pdb:6KAO|rcsb pdb:6KAP|rcsb pdb:6KAQ|rcsb pdb:6KAR|rcsb pdb:6KAS|rcsb pdb:6KAT|rcsb pdb:4N7N|rcsb pdb:6KAU|rcsb pdb:4N7O|rcsb pdb:4N7P|rcsb pdb:6KAV|rcsb pdb:4N8T|rcsb pdb:6KYE|rcsb pdb:6L5V|rcsb pdb:6L5W|rcsb pdb:6L5X|rcsb pdb:6L5Y|rcsb pdb:6LCW|rcsb pdb:6LCX|rcsb pdb:4NI0|rcsb pdb:4NI1|rcsb pdb:4ROL|rcsb pdb:4ROM|rcsb pdb:4WJG|rcsb pdb:6NBC|rcsb pdb:6NBD|rcsb pdb:6NQ5|rcsb pdb:6TB2|rcsb pdb:6XD9|rcsb pdb:6XDT|rcsb pdb:6XE7|rcsb pdb:7AET|rcsb pdb:7AEV|rcsb pdb:7JJQ|rcsb pdb:7JXZ|rcsb pdb:7JY0|rcsb pdb:7JY1|rcsb pdb:7JY3|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-2168880|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:7AEU|refseq:NP_000508.1|refseq:NP_000549.1|rcsb pdb:1GBU|rcsb pdb:1GBV|rcsb pdb:1GLI|rcsb pdb:1GZX|rcsb pdb:1HAB|rcsb pdb:1HAC|rcsb pdb:1HBA|rcsb pdb:1HBB|rcsb pdb:1HBS|rcsb pdb:1HCO|rcsb pdb:1HDB|rcsb pdb:1HGA|rcsb pdb:1HGB|rcsb pdb:1HGC|rcsb pdb:1HHO|rcsb pdb:1IRD|rcsb pdb:1J3Y|rcsb pdb:1J3Z|rcsb pdb:1J40|rcsb pdb:1J41|rcsb pdb:1J7S|rcsb pdb:1J7W|rcsb pdb:1J7Y|rcsb pdb:1JY7|rcsb pdb:1K0Y|rcsb pdb:1K1K|rcsb pdb:1KD2|rcsb pdb:1LFL|rcsb pdb:1LFQ|rcsb pdb:1LFT|rcsb pdb:1LFV|rcsb pdb:1LFY|rcsb pdb:1LFZ|rcsb pdb:1LJW|rcsb pdb:1M9P|rcsb pdb:1MKO|rcsb pdb:1NEJ|rcsb pdb:1NIH|rcsb pdb:1NQP|rcsb pdb:1O1I|rcsb pdb:1O1J|rcsb pdb:1O1K|rcsb pdb:1O1L|rcsb pdb:1O1M|rcsb pdb:1O1N|rcsb pdb:1O1O|rcsb pdb:1O1P|rcsb pdb:1QI8|rcsb pdb:1QSH|rcsb pdb:1QSI|rcsb pdb:1QXD|rcsb pdb:1QXE|rcsb pdb:1R1X|rcsb pdb:1R1Y|rcsb pdb:1RPS|rcsb pdb:1RQ3|rcsb pdb:1RQ4|rcsb pdb:1RQA|rcsb pdb:1RVW|rcsb pdb:1SDK|rcsb pdb:1SDL|rcsb pdb:1SHR|rcsb pdb:1SI4|rcsb pdb:1THB|rcsb pdb:1UIW|rcsb pdb:1VWT|rcsb pdb:1XXT|rcsb pdb:1XY0|rcsb pdb:1XYE|rcsb pdb:1XZ2|rcsb pdb:1XZ4|rcsb pdb:1XZ5|rcsb pdb:1XZ7|rcsb pdb:1XZU|rcsb pdb:1XZV|rcsb pdb:1Y01|rcsb pdb:1Y09|rcsb pdb:1Y0A|rcsb pdb:1Y0C|rcsb pdb:1Y0D|rcsb pdb:1Y0T|rcsb pdb:1Y0W|rcsb pdb:1Y22|rcsb pdb:1Y2Z|rcsb pdb:1Y31|rcsb pdb:1Y35|rcsb pdb:1Y45|rcsb pdb:1Y46|rcsb pdb:1Y4B|rcsb pdb:1Y4F|rcsb pdb:1Y4G|rcsb pdb:1Y4P|rcsb pdb:1Y4Q|rcsb pdb:1Y4R|rcsb pdb:1Y4V|rcsb pdb:1Y5F|rcsb pdb:1Y5J|rcsb pdb:1Y5K|rcsb pdb:1Y7C|rcsb pdb:1Y7D|rcsb pdb:1Y7G|rcsb pdb:1Y7Z|rcsb pdb:1Y83|rcsb pdb:1Y85|rcsb pdb:1Y8W|rcsb pdb:1YDZ|rcsb pdb:1YE0|rcsb pdb:1YE1|rcsb pdb:1YE2|rcsb pdb:1YEN|rcsb pdb:1YEO|rcsb pdb:1YEQ|rcsb pdb:1YEU|rcsb pdb:1YEV|rcsb pdb:1YFF|rcsb pdb:1YG5|rcsb pdb:1YGD|rcsb pdb:1YGF|rcsb pdb:1YH9|rcsb pdb:1YHE|rcsb pdb:1YHR|rcsb pdb:1YIE|rcsb pdb:1YIH|dip:DIP-35199N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M4o0FF1DIrouBdyFXr4UtAlcjZw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21912	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63220	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714051|uniprotkb:P35265|ensembl:ENSP00000345957	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs21_human(display_long)|uniprotkb:RPS21(gene name)|psi-mi:RPS21(display_short)|uniprotkb:Small ribosomal subunit protein eS21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000171858(gene)|ensembl:ENST00000343986(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000461"("endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001015.1|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR001931(Ribosomal protein S21e)|interpro:IPR018279|interpro:IPR038579|mint:P63220|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6ZMO|rcsb pdb:6G5H|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6G5I|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:7K5I|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3gi91+fAL7ogzcoJlVEaN4D+87A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P0L0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49915	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050289|uniprotkb:A8K639|uniprotkb:B4DXV7|uniprotkb:F8W720|ensembl:ENSP00000419851	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:guaa_human(display_long)|uniprotkb:GMP synthetase(gene name synonym)|uniprotkb:Glutamine amidotransferase(gene name synonym)|uniprotkb:GMPS(gene name)|psi-mi:GMPS(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003866.1|ensembl:ENSG00000163655(gene)|ensembl:ENST00000496455(transcript)|go:"GO:0003921"(GMP synthase activity)|go:"GO:0003922"("GMP synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0016462"(pyrophosphatase activity)|interpro:IPR001674(GMP synthase, C-terminal)|interpro:IPR004739(GMP synthase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017926|interpro:IPR022310|interpro:IPR025777|interpro:IPR029062|mint:P49915|rcsb pdb:2VPI|rcsb pdb:2VXO|reactome:R-HSA-73817	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LYs65bPoqjVG/ZxA6v+yJo3HsLI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95036	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190520	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:o95036_human(display_long)|uniprotkb:"WUGSC:H_RG054D04.1"(gene name)|psi-mi:"WUGSC:H_RG054D04.1"(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR018038|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/Wx1NRwTL4OL8HlPLKeaZ568pCA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35579	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08865	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354112|uniprotkb:Q6NSD1|uniprotkb:Q6NXQ8|uniprotkb:Q86VC0|uniprotkb:P11085|uniprotkb:P12030|uniprotkb:Q16471|uniprotkb:Q6IPD1|uniprotkb:Q6IPD2|ensembl:ENSP00000346067	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rssa_human(display_long)|uniprotkb:RPSA(gene name)|psi-mi:RPSA(display_short)|uniprotkb:LAMBR(gene name synonym)|uniprotkb:LAMR1(gene name synonym)|uniprotkb:Laminin receptor 1(gene name synonym)|uniprotkb:37/67 kDa laminin receptor(gene name synonym)|uniprotkb:Laminin-binding protein precursor p40(gene name synonym)|uniprotkb:Colon carcinoma laminin-binding protein(gene name synonym)|uniprotkb:NEM/1CHD4(gene name synonym)|uniprotkb:Multidrug resistance-associated protein MGr1-Ag(gene name synonym)|uniprotkb:37 kDa laminin receptor precursor(gene name synonym)|uniprotkb:67 kDa laminin receptor(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002286.2|refseq:NP_001291217.1|dip:DIP-32878N|ensembl:ENSG00000168028(gene)|ensembl:ENST00000301821(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0007155"(cell adhesion)|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZOJ|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0043022"(ribosome binding)|go:"GO:0043236"(laminin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001865(Ribosomal protein S2)|interpro:IPR005707(Ribosomal protein S2, eukaryotic/archaeal)|interpro:IPR018130|interpro:IPR023591|interpro:IPR027498|interpro:IPR027504|interpro:IPR032281|mint:P08865|rcsb pdb:3BCH|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Jpv3I3G5C297fHfNwIqyB9Pf8/A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O76003	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374781|uniprotkb:Q96CE0|uniprotkb:Q9P1B0|uniprotkb:Q9P1B1|uniprotkb:B3KMP7|uniprotkb:B3KMQ5|uniprotkb:Q5JV01|ensembl:ENSP00000330836|ensembl:ENSP00000357633|ensembl:ENSP00000435445|uniprotkb:D3DRG2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:glrx3_human(display_long)|uniprotkb:GLRX3(gene name)|psi-mi:GLRX3(display_short)|uniprotkb:Thioredoxin-like protein 2(gene name synonym)|uniprotkb:PKC-interacting cousin of thioredoxin(gene name synonym)|uniprotkb:PKC-theta-interacting protein(gene name synonym)|uniprotkb:PICOT(gene name synonym)|uniprotkb:HUSSY-22(orf name)|uniprotkb:TXNL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108010(gene)|ensembl:ENST00000331244(transcript)|ensembl:ENST00000368644(transcript)|ensembl:ENST00000481034(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0097573"(glutathione oxidoreductase activity)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249|mint:O76003|rcsb pdb:2DIY|rcsb pdb:2WZ9|rcsb pdb:2YAN|rcsb pdb:3ZYW|reactome:R-HSA-917937|refseq:NP_001186797.1|refseq:NP_006532.2|dip:DIP-31306N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iKUSt6zbNzzXSKvW+vXMq3hKsEM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96AG4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358888|uniprotkb:Q9P189|uniprotkb:D3DTX8|ensembl:ENSP00000225972|uniprotkb:B2RE83	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lrc59_human(display_long)|uniprotkb:LRRC59(gene name)|psi-mi:LRRC59(display_short)|uniprotkb:Ribosome-binding protein p34(gene name synonym)|uniprotkb:PRO1855(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060979.2|ensembl:ENSG00000108829(gene)|ensembl:ENST00000225972(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045296"(cadherin binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q96AG4	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gAtWed9Jv69oHdkEFgpWGFnvcWE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52789	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-741469|uniprotkb:Q8WU87|uniprotkb:Q9UN82|ensembl:ENSP00000290573|uniprotkb:D6W5J2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hxk2_human(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Muscle form hexokinase(gene name synonym)|uniprotkb:HK2(gene name)|psi-mi:HK2(display_short)|uniprotkb:Hexokinase-B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|mint:P52789|rcsb pdb:2NZT|rcsb pdb:5HEX|rcsb pdb:5HFU|rcsb pdb:5HG1|reactome:R-HSA-70171|go:"GO:0008865"(fructokinase activity)|ensembl:ENSG00000159399(gene)|ensembl:ENST00000290573(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|refseq:NP_000180.2|dip:DIP-50110N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:99w5KbKmsqMoorQz/wot6z6t2WM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61247	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352378|uniprotkb:P33443|uniprotkb:P49241|uniprotkb:B2R4D4|intact:EBI-3440915|uniprotkb:D3DP05|ensembl:ENSP00000346050	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs3a_human(display_long)|uniprotkb:RPS3A(gene name)|psi-mi:RPS3A(display_short)|uniprotkb:MFTL(gene name synonym)|uniprotkb:FTE1(gene name synonym)|uniprotkb:v-fos transformation effector protein(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000997.1|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:4V6X|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000145425(gene)|ensembl:ENST00000274065(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|mint:P61247|rcsb pdb:4UG0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6OM7|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-29408N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:g1TMzz8OFWEuhrRCoecj7KW0qTQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9ULH0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716681|uniprotkb:A1L4N4|intact:EBI-2798329|uniprotkb:Q6MZU2|uniprotkb:Q9H889|uniprotkb:Q9H9E4|uniprotkb:Q9NT37|uniprotkb:Q9UF42|uniprotkb:Q4VC08|ensembl:ENSP00000256707	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kdis_human(display_long)|uniprotkb:KIAA1250(gene name synonym)|uniprotkb:KIDINS220(gene name)|psi-mi:KIDINS220(display_short)|uniprotkb:ARMS(gene name synonym)|uniprotkb:Ankyrin repeat-rich membrane-spanning protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065789.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000134313(gene)|ensembl:ENST00000256707(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR002110(Ankyrin)|interpro:IPR011646(KAP P-loop)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9ULH0|reactome:R-HSA-170984|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0wyaXuvXCqQTlfjuW4TAcIGmdlw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473271|uniprotkb:Q2NKN2|uniprotkb:Q59EA1|ensembl:ENSP00000296702	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcrg1_human(display_long)|uniprotkb:TATA box-binding protein-associated factor 2S(gene name synonym)|uniprotkb:Transcription factor CA150(gene name synonym)|uniprotkb:TCERG1(gene name)|psi-mi:TCERG1(display_short)|uniprotkb:CA150(gene name synonym)|uniprotkb:TAF2S(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035095.1|refseq:NP_006697.2|dip:DIP-32504N|ensembl:ENSG00000113649(gene)|ensembl:ENST00000296702(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003711"(transcription elongation regulator activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0042802"(identical protein binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002713(FF)|interpro:IPR036020|interpro:IPR036517|mint:O14776|rcsb pdb:2DK7|rcsb pdb:2DOD|rcsb pdb:2DOE|rcsb pdb:2DOF|rcsb pdb:2E71|rcsb pdb:2KIQ|rcsb pdb:2KIS|rcsb pdb:2MW9|rcsb pdb:2MWA|rcsb pdb:2MWB|rcsb pdb:2MWD|rcsb pdb:2MWE|rcsb pdb:2MWF|rcsb pdb:2N4R|rcsb pdb:2N4S|rcsb pdb:2N4T|rcsb pdb:2N4U|rcsb pdb:2N4V|rcsb pdb:2N4W|rcsb pdb:2NNT|rcsb pdb:3HFH|rcsb pdb:3Q1I|rcsb pdb:4FQG|rcsb pdb:7ABF|rcsb pdb:7ABG	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KDFTOtTUWHzQ9yzRj7BbhFTQXiM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69892	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3910089|uniprotkb:A8MZE0|uniprotkb:P02096|uniprotkb:Q14491|uniprotkb:Q68NH9|uniprotkb:Q96FH6|uniprotkb:P62027|uniprotkb:Q96FH7|ensembl:ENSP00000338082	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg2_human(display_long)|uniprotkb:HBG2(gene name)|psi-mi:HBG2(display_short)|uniprotkb:Gamma-2-globin(gene name synonym)|uniprotkb:Hb F Ggamma(gene name synonym)|uniprotkb:Hemoglobin gamma-2 chain(gene name synonym)|uniprotkb:Hemoglobin gamma-G chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000175.1|ensembl:ENSG00000196565(gene)|ensembl:ENST00000336906(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1FDH|rcsb pdb:4MQJ|rcsb pdb:4MQK|reactome:R-HSA-983231|interpro:IPR002337(Haemoglobin, beta)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nhCM/lc1Dqw+ZTSHjiiyHcJIobk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B0JYQ0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b0jyq0_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005615"(extracellular space)|go:"GO:0046872"(metal ion binding)|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZRiIE/g0lqxM4BoYZ1F4bLVNdos9913	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61225	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750871|uniprotkb:P17964|uniprotkb:Q96EG5|uniprotkb:Q9CXG0|ensembl:ENSP00000319096	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rap2b_human(display_long)|uniprotkb:RAP2B(gene name)|psi-mi:RAP2B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002877.2|ensembl:ENSG00000181467(gene)|ensembl:ENST00000323534(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0035579"(specific granule membrane)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dFHHIYuDf3lTGSX0Nys6IE9ONvs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46778	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350634|uniprotkb:Q16699|ensembl:ENSP00000346027|ensembl:ENSP00000351021|ensembl:ENSP00000370569|ensembl:ENSP00000370574	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl21_human(display_long)|uniprotkb:RPL21(gene name)|psi-mi:RPL21(display_short)|uniprotkb:Large ribosomal subunit protein eL21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6LU8|refseq:NP_000973.2|ensembl:ENSG00000122026(gene)|ensembl:ENST00000272274(transcript)|ensembl:ENST00000311549(transcript)|ensembl:ENST00000319826(transcript)|ensembl:ENST00000326092(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001147(Ribosomal protein L21e)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:P46778|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6OLE|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UCth+WL9Oj1Y9I5m4i/9X0a5WHk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y520	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2685847|uniprotkb:Q05DM8|uniprotkb:Q9HA05|uniprotkb:Q9UF29|uniprotkb:Q9NSM8|uniprotkb:Q9H2N2|uniprotkb:Q9NXL3|uniprotkb:Q6PD54|uniprotkb:Q49A39|uniprotkb:Q9UPQ6|intact:EBI-2824421	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prc2c_human(display_long)|uniprotkb:BAT2D1(gene name synonym)|uniprotkb:KIAA1096(gene name synonym)|uniprotkb:XTP2(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HBV X-transactivated gene 2 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 2(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:PRRC2C(gene name)|psi-mi:PRRC2C(display_short)|uniprotkb:BAT2L2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055987.2|refseq:XP_006711301.1|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|ensembl:ENST00000338920|ensembl:ENSP00000343629|ensembl:ENSG00000117523|ensembl:ENST00000426496|ensembl:ENSP00000410219|ensembl:ENST00000647382|ensembl:ENSP00000495867|refseq:XP_005245074.1|dip:DIP-47285N|mint:Q9Y520	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qecMuJHnm8n95OFpT+m+i9JbBoo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5J1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-592816|uniprotkb:Q9H4N6|ensembl:ENSP00000225298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:utp18_human(display_long)|uniprotkb:WD repeat-containing protein 50(gene name synonym)|uniprotkb:UTP18(gene name)|psi-mi:UTP18(display_short)|uniprotkb:CGI-48(orf name)|uniprotkb:CDABP0061(orf name)|uniprotkb:WDR50(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057085.2|ensembl:ENSG00000011260(gene)|ensembl:ENST00000225298(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q9Y5J1|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l873IUyfCql4N9VelHPuUEqpzRY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42704	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02543	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350523|ensembl:ENSP00000222247	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl18a_human(display_long)|uniprotkb:RPL18A(gene name)|psi-mi:RPL18A(display_short)|uniprotkb:Large ribosomal subunit protein eL20(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000971.1|interpro:IPR021138|interpro:IPR023573|interpro:IPR028877|mint:Q02543|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|go:"GO:0097327"(response to antineoplastic agent)|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|ensembl:ENSG00000105640(gene)|ensembl:ENST00000222247(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|rcsb pdb:6ZME|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O9XdW7Let2GcJpJLVuUtatVVv1I9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q05D08	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190283	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q05d08_human(display_long)|uniprotkb:PA2G4(gene name)|psi-mi:PA2G4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR036388|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR018349|interpro:IPR036005|interpro:IPR036390	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JuKG8gmkmCiPRNyb6FtLmZUBbCI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23396	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351193|uniprotkb:Q498B5|uniprotkb:Q8NI95|uniprotkb:B2R7N5|ensembl:ENSP00000433821|ensembl:ENSP00000434643|ensembl:ENSP00000436971|uniprotkb:J3KN86	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs3_human(display_long)|uniprotkb:RPS3(gene name)|psi-mi:RPS3(display_short)|uniprotkb:Small ribosomal subunit protein uS3(gene name synonym)|uniprotkb:OK/SW-cl.26(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000996.2|ensembl:ENSG00000149273(gene)|ensembl:ENST00000524851(transcript)|ensembl:ENST00000527446(transcript)|ensembl:ENST00000531188(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032358"(oxidized pyrimidine DNA binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045738"(negative regulation of DNA repair)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061481"(response to TNF agonist)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902546"(positive regulation of DNA N-glycosylase activity)|go:"GO:1905053"(positive regulation of base-excision repair)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR004044(K Homology, type 2)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|go:"GO:0071159"(NF-kappaB complex)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR018280|interpro:IPR036419|mint:P23396|rcsb pdb:1WH9|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|go:"GO:0072686"(mitotic spindle)|go:"GO:0097100"(supercoiled DNA binding)|rcsb pdb:6QZP|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|refseq:NP_001243731.1|refseq:NP_001247436.1|refseq:NP_001247435.1|dip:DIP-33177N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fsDW18AMR3YyEEIhMVcngYRWkps9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00839	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A6NKE1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190709|ensembl:ENSP00000362253	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:a6nke1_human(display_long)|uniprotkb:TRAPPC3(gene name)|psi-mi:TRAPPC3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000054116(gene)|ensembl:ENST00000373159(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030008"(TRAPP complex)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR016721(TRAPP I complex, Bet3)|interpro:IPR024096|interpro:IPR007194("Transport protein particle (TRAPP) component, Bet3")	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:39R93986KCjktIWg8GOua2Ak/j89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69891	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056789|uniprotkb:P02096|uniprotkb:P62027|uniprotkb:Q96FH7|uniprotkb:Q8TDA1|uniprotkb:Q549G1|ensembl:ENSP00000327431	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg1_human(display_long)|uniprotkb:HBG1(gene name)|psi-mi:HBG1(display_short)|uniprotkb:Hemoglobin gamma-1 chain(gene name synonym)|uniprotkb:Gamma-1-globin(gene name synonym)|uniprotkb:Hemoglobin gamma-A chain(gene name synonym)|uniprotkb:Hb F Agamma(gene name synonym)|uniprotkb:PRO2979(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000550.2|ensembl:ENSG00000213934(gene)|ensembl:ENST00000330597(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1I3D|rcsb pdb:1I3E|reactome:R-HSA-983231	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iJ4HIirEDw3t7jxBcbZLma4HgXE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49591	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053431|uniprotkb:Q5T5C8|uniprotkb:Q9NSE3|uniprotkb:B2R6Y9|ensembl:ENSP00000234677	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sysc_human(display_long)|uniprotkb:SARS1(gene name)|psi-mi:SARS1(display_short)|uniprotkb:SARS(gene name synonym)|uniprotkb:SERS(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006504.2|ensembl:ENSG00000031698(gene)|ensembl:ENST00000234677(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:1904046"(negative regulation of vascular endothelial growth factor production)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR015866(Seryl-tRNA synthetase, class IIa, N-terminal)|interpro:IPR033729|interpro:IPR042103|rcsb pdb:3VBB|rcsb pdb:4L87|rcsb pdb:4RQE|rcsb pdb:4RQF|reactome:R-HSA-2408557|reactome:R-HSA-379716|dip:DIP-38215N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4+Ai/MIybmiKJyfa0C0bhnW/CG49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P84098	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-916524|uniprotkb:P14118|uniprotkb:P22908|uniprotkb:Q502Y6|uniprotkb:Q7Z6E4|uniprotkb:B2R4K2|ensembl:ENSP00000225430	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl19_human(display_long)|uniprotkb:RPL19(gene name)|psi-mi:RPL19(display_short)|uniprotkb:Large ribosomal subunit protein eL19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000972.1|ensembl:ENSG00000108298(gene)|ensembl:ENST00000225430(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000196(Ribosomal protein L19/L19e)|interpro:IPR015972(Ribosomal protein L19/L19e, domain 1)|interpro:IPR023638|interpro:IPR033935|interpro:IPR035970|interpro:IPR039547|mint:P84098|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sYEwdB8ySbxh3iL0uqlfRRVFiWw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61224	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BSJ8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355956|ensembl:ENSP00000377612|uniprotkb:A0FGR7|uniprotkb:A8K2S2|uniprotkb:O94848|uniprotkb:Q6PJN4|uniprotkb:Q9H6J1|uniprotkb:Q9H6W2|uniprotkb:Q9Y416|intact:EBI-4399548	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:esyt1_human(display_long)|uniprotkb:KIAA0747(gene name synonym)|uniprotkb:MBC2(gene name synonym)|uniprotkb:ESYT1(gene name)|psi-mi:ESYT1(display_short)|uniprotkb:Membrane-bound C2 domain-containing protein(gene name synonym)|uniprotkb:FAM62A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR037752|interpro:IPR039010|mint:Q9BSJ8|reactome:R-HSA-1660662|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9035034|interpro:IPR037749|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037733|go:"GO:0005544"(calcium-dependent phospholipid binding)|ensembl:ENSG00000139641(gene)|ensembl:ENST00000394048(transcript)|go:"GO:0005509"(calcium ion binding)|refseq:NP_001171725.1|refseq:NP_056107.1|dip:DIP-57197N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MYbYK3357LLH0TP1qU7CsvJenGk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75367	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2868511|uniprotkb:Q7Z5E3|uniprotkb:Q9UP96|uniprotkb:Q9H8P3|uniprotkb:Q503A8|uniprotkb:O75377|uniprotkb:Q96D41|ensembl:ENSP00000423563|ensembl:ENSP00000424971	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h2ay_human(display_long)|uniprotkb:MACROH2A1(gene name)|psi-mi:MACROH2A1(display_short)|uniprotkb:H2AFY(gene name synonym)|uniprotkb:Histone H2A.y(gene name synonym)|uniprotkb:Medulloblastoma antigen MU-MB-50.205(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011542031.1|refseq:XP_011542032.1|refseq:NP_001035248.1|refseq:NP_004884.1|refseq:NP_613075.1|refseq:NP_613258.2|dip:DIP-44283N|ensembl:ENSG00000113648(gene)|ensembl:ENST00000510038(transcript)|ensembl:ENST00000511689(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000182"(rDNA binding)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0007549"(dosage compensation)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902750"(negative regulation of cell cycle G2/M phase transition)|go:"GO:1902882"(regulation of response to oxidative stress)|go:"GO:1902883"(negative regulation of response to oxidative stress)|go:"GO:1902884"(positive regulation of response to oxidative stress)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|go:"GO:1904815"(negative regulation of protein localization to chromosome, telomeric region)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|interpro:IPR032454|interpro:IPR035796|interpro:IPR043472|mint:O75367|rcsb pdb:1U35|rcsb pdb:1ZR3|rcsb pdb:1ZR5|rcsb pdb:2F8N|rcsb pdb:2FXK|rcsb pdb:3HQH|rcsb pdb:3HSV|rcsb pdb:3IID|rcsb pdb:3IIF|rcsb pdb:3IVB|rcsb pdb:5IIT|rcsb pdb:5LNC|interpro:IPR002119(Histone H2A)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0FCoM0/4mTtnc7cPDUleKuZ3HgM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BZL1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-607755|ensembl:ENSP00000351492|ensembl:ENSP00000466910|ensembl:ENSP00000468656|uniprotkb:Q2NL89	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubl5_human(display_long)|uniprotkb:UBL5(gene name)|psi-mi:UBL5(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198258(gene)|ensembl:ENST00000358666(transcript)|ensembl:ENST00000586895(transcript)|ensembl:ENST00000590068(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0031386"(protein tag)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039732|rcsb pdb:1P0R|rcsb pdb:4PYU|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:6AHD|refseq:NP_001041706.1|refseq:NP_077268.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tm6rC2ylXI3og2IqNXSHmgi2f/09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26639	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042683|uniprotkb:Q96FP5|uniprotkb:Q9BWA6|uniprotkb:A8K8I1|ensembl:ENSP00000265112|ensembl:ENSP00000424387|uniprotkb:B4DEG8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sytc_human(display_long)|uniprotkb:TARS1(gene name)|psi-mi:TARS1(display_short)|uniprotkb:TARS(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_689508.3|refseq:NP_001245367.1|rcsb pdb:4HWT|rcsb pdb:4P3N|rcsb pdb:4TTV|rcsb pdb:5XLN|reactome:R-HSA-379716|refseq:NP_001245366.1|go:"GO:0005829"(cytosol)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|ensembl:ENSG00000113407(gene)|interpro:IPR012676(TGS-like)|ensembl:ENST00000265112(transcript)|ensembl:ENST00000502553(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|mint:P26639|rcsb pdb:1WWT	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Z+rOaI1ZO1TQftfkRn1HhXUqDAk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06493	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43390	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713419|uniprotkb:S4R3J4|uniprotkb:Q5TEH1|ensembl:ENSP00000304405|ensembl:ENSP00000363741|ensembl:ENSP00000489252|ensembl:ENSP00000489371|uniprotkb:Q9BV64|uniprotkb:Q2L7G6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpr_human(display_long)|uniprotkb:HNRPR(gene name synonym)|uniprotkb:HNRNPR(gene name)|psi-mi:HNRNPR(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001095868.1|refseq:XP_005245768.1|ensembl:ENSG00000125944(gene)|ensembl:ENSG00000282958(gene)|ensembl:ENST00000302271(transcript)|ensembl:ENST00000374612(transcript)|ensembl:ENST00000634263(transcript)|ensembl:ENST00000634766(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043679"(axon terminus)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034411|interpro:IPR035979|mint:O43390|rcsb pdb:2DK2|reactome:R-HSA-72163|reactome:R-HSA-72203|interpro:IPR041337|refseq:NP_005817.1|refseq:XP_011538773.1|refseq:NP_001284549.1|refseq:XP_016855497.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UiOaRbnMd1S2FthR4RWltyq6xT49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P37108	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353399|uniprotkb:Q6B0K5|intact:EBI-1053250|uniprotkb:Q96Q14|uniprotkb:B5BUF5|ensembl:ENSP00000267884	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srp14_human(display_long)|uniprotkb:SRP14(gene name)|psi-mi:SRP14(display_short)|uniprotkb:18 kDa Alu RNA-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003125.3|dip:DIP-6152N|ensembl:ENSG00000140319(gene)|ensembl:ENST00000267884(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045047"(protein targeting to ER)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003210(Signal recognition particle, SRP14 subunit)|interpro:IPR009018(Signal recognition particle, SRP9/SRP14 subunit)|mint:P37108|rcsb pdb:1E8O|rcsb pdb:1E8S|rcsb pdb:1RY1|rcsb pdb:4UYJ|rcsb pdb:4UYK|rcsb pdb:5AOX|rcsb pdb:7NFX|reactome:R-HSA-1799339|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0xHelIgJbXaUrFsHGoj1wDQKdPs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07947	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09651	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352662|uniprotkb:Q3MIB7|uniprotkb:Q6PJZ7|ensembl:ENSP00000341826|ensembl:ENSP00000503610|uniprotkb:A8K4Z8|intact:EBI-2556572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa1_human(display_long)|uniprotkb:HNRNPA1(gene name)|psi-mi:HNRNPA1(display_short)|uniprotkb:HNRPA1(gene name synonym)|uniprotkb:Helix-destabilizing protein(gene name synonym)|uniprotkb:Single-strand RNA-binding protein(gene name synonym)|uniprotkb:hnRNP core protein A1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002127.1|refseq:NP_112420.1|ensembl:ENSG00000135486(gene)|ensembl:ENST00000340913(transcript)|ensembl:ENST00000677210(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|rcsb pdb:2LYV|rcsb pdb:2UP1|rcsb pdb:4YOE|rcsb pdb:5MPG|rcsb pdb:5MPL|rcsb pdb:5ZGD|rcsb pdb:5ZGL|rcsb pdb:6BXX|rcsb pdb:6DCL|rcsb pdb:6J60|rcsb pdb:7BX7|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035198"(miRNA binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051168"(nuclear export)|go:"GO:0051170"(import into nucleus)|go:"GO:0061752"(telomeric repeat-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR034845|interpro:IPR035979|mint:P09651|rcsb pdb:1HA1|rcsb pdb:1L3K|rcsb pdb:1PGZ|rcsb pdb:1PO6|rcsb pdb:1U1K|rcsb pdb:1U1L|rcsb pdb:1U1M|rcsb pdb:1U1N|rcsb pdb:1U1O|rcsb pdb:1U1P|rcsb pdb:1U1Q|rcsb pdb:1U1R|rcsb pdb:1UP1|rcsb pdb:2H4M|refseq:XP_005268883.1|dip:DIP-29338N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ECXjsLRVtNc/aOw90tEFxowHc6c9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B1AKQ8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190833|ensembl:ENSP00000416651	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b1akq8_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000078369(gene)|ensembl:ENST00000437146(transcript)|go:"GO:0007165"(signal transduction)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR036322	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BUB/7mf+WlDyk4rDXHXUrW9rKWE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355720|uniprotkb:Q6IB85|uniprotkb:Q6NE84|ensembl:ENSP00000300291	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpsf5_human(display_long)|uniprotkb:NUDT21(gene name)|psi-mi:NUDT21(display_short)|uniprotkb:CFIM25(gene name synonym)|uniprotkb:CPSF25(gene name synonym)|uniprotkb:CPSF5(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 25 kDa subunit(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 21(gene name synonym)|uniprotkb:Cleavage factor Im complex 25 kDa subunit(gene name synonym)|uniprotkb:Nudix hydrolase 21(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 68 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_008937.1|ensembl:ENSG00000167005(gene)|ensembl:ENST00000300291(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006397"(mRNA processing)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031439"(positive regulation of mRNA cleavage)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2000975"(positive regulation of pro-B cell differentiation)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR016706(Cleavage and polyadenylation specificity factor, 25 kDa subunit)|mint:O43809|rcsb pdb:2CL3|rcsb pdb:2J8Q|rcsb pdb:3BAP|rcsb pdb:3BHO|rcsb pdb:3MDG|rcsb pdb:3MDI|rcsb pdb:3N9U|rcsb pdb:3P5T|rcsb pdb:3P6Y|rcsb pdb:3Q2S|rcsb pdb:3Q2T|rcsb pdb:5R4P|rcsb pdb:5R4Q|rcsb pdb:5R4R|rcsb pdb:5R4S|rcsb pdb:5R4T|rcsb pdb:5R4U|rcsb pdb:5R64|rcsb pdb:5R65|rcsb pdb:5R66|rcsb pdb:5R67|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|dip:DIP-42502N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Acad4mYVuS+Eox+X2CH8PYUkGAA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15286	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722275|uniprotkb:B4E390|uniprotkb:B2R6E0|ensembl:ENSP00000229340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab35_human(display_long)|uniprotkb:Ras-related protein Rab-1C(gene name synonym)|uniprotkb:GTP-binding protein RAY(gene name synonym)|uniprotkb:RAB35(gene name)|psi-mi:RAB35(display_short)|uniprotkb:RAB1C(gene name synonym)|uniprotkb:RAY(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001161078.1|refseq:NP_006852.1|ensembl:ENSG00000111737(gene)|ensembl:ENST00000229340(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042470"(melanosome)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041815|mint:Q15286|rcsb pdb:3TW8|rcsb pdb:6EKK|rcsb pdb:6IF2|rcsb pdb:6IF3|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:95pH+DyDjv9FcxFeMmGYoJ0KyPo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75477	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359299|uniprotkb:B0QZ42|uniprotkb:Q53HV0|ensembl:ENSP00000384900|ensembl:ENSP00000410964|intact:EBI-21351077|uniprotkb:D3DR65	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:erln1_human(display_long)|uniprotkb:KEO4(gene name synonym)|uniprotkb:ERLIN1(gene name)|psi-mi:ERLIN1(display_short)|uniprotkb:C10orf69(gene name synonym)|uniprotkb:KE04(gene name synonym)|uniprotkb:SPFH1(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 1(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1(gene name synonym)|uniprotkb:Protein KE04(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001094096.1|refseq:NP_006450.2|ensembl:ENSG00000107566(gene)|ensembl:ENST00000407654(transcript)|ensembl:ENST00000421367(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O75477|reactome:R-HSA-382556|reactome:R-HSA-5678895|refseq:NP_001334786.1|refseq:NP_001334788.1|refseq:NP_001334789.1|refseq:NP_001334790.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HycFhL5qL5GLmaIIc9NtTcBbu1M9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00560	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727004|uniprotkb:O43391|ensembl:ENSP00000260130|ensembl:ENSP00000411771|uniprotkb:O00173|uniprotkb:Q14CP2|uniprotkb:B4DUH3|uniprotkb:B7ZLN2|uniprotkb:B2R5Q7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdcb1_human(display_long)|uniprotkb:Scaffold protein Pbp1(gene name synonym)|uniprotkb:Pro-TGF-alpha cytoplasmic domain-interacting protein 18(gene name synonym)|uniprotkb:Syndecan-binding protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 9(gene name synonym)|uniprotkb:SDCBP(gene name)|psi-mi:SDCBP(display_short)|uniprotkb:MDA9(gene name synonym)|uniprotkb:SYCL(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000137575(gene)|ensembl:ENST00000260130(transcript)|ensembl:ENST00000413219(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005109"(frizzled binding)|go:"GO:0005137"(interleukin-5 receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|refseq:NP_001007068.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005895"(interleukin-5 receptor complex)|go:"GO:0005912"(adherens junction)|refseq:NP_001007069.1|refseq:NP_001007070.1|refseq:NP_001007071.1|refseq:NP_005616.2|go:"GO:0005925"(focal adhesion)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030528|interpro:IPR036034|go:"GO:0042802"(identical protein binding)|rcsb pdb:1N99|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:1NTE|go:"GO:0045121"(membrane raft)|rcsb pdb:1OBX|rcsb pdb:1OBY|rcsb pdb:1OBZ|go:"GO:0045202"(synapse)|go:"GO:0045545"(syndecan binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:1R6J|rcsb pdb:1V1T|rcsb pdb:1W9E|rcsb pdb:1W9O|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0099054"(presynapse assembly)|go:"GO:1903543"(positive regulation of exosomal secretion)|rcsb pdb:1W9Q|rcsb pdb:1YBO|rcsb pdb:4Z33|rcsb pdb:6R9H|rcsb pdb:6RLC|reactome:R-HSA-3928664|reactome:R-HSA-447043|reactome:R-HSA-5213460|reactome:R-HSA-6798695|reactome:R-HSA-5675482|dip:DIP-42705N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ys2RNVwH0n5AKA+rBULM9Foxccg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P2J5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356077|uniprotkb:Q9NSE1|uniprotkb:A2RRR4|uniprotkb:B4DJ10|uniprotkb:Q2TU79|uniprotkb:A7E266|ensembl:ENSP00000377954	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sylc_human(display_long)|uniprotkb:LARS1(gene name)|psi-mi:LARS1(display_short)|uniprotkb:KIAA1352(gene name synonym)|uniprotkb:LARS(gene name synonym)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_064502.9|refseq:NP_001304893.1|refseq:NP_001304894.1|refseq:NP_057544.2|refseq:XP_011535958.1|ensembl:ENSG00000133706(gene)|ensembl:ENST00000394434(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0012505"(endomembrane system)|go:"GO:0016604"(nuclear body)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|mint:Q9P2J5|rcsb pdb:2WFD|rcsb pdb:6KID|rcsb pdb:6KIE|rcsb pdb:6KQY|rcsb pdb:6KR7|rcsb pdb:6LPF|rcsb pdb:6LR6|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nlK4kRCik2LLC3VNl0sryrLLnqA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62310	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348239|ensembl:ENSP00000302160|uniprotkb:Q9Y4Z1|uniprotkb:Q6IAH0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lsm3_human(display_long)|uniprotkb:MDS017(orf name)|uniprotkb:LSM3(gene name)|psi-mi:LSM3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000170860(gene)|ensembl:ENST00000306024(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0030629"(U6 snRNA 3'-end binding)|go:"GO:0033962"(P-body assembly)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034105|interpro:IPR040002|mint:P62310|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|refseq:NP_055278.1|dip:DIP-31218N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+OnRI9eJcsd1xJe+cUCP7Y/9tt09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5SRE5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049404|uniprotkb:Q14675|uniprotkb:Q2TA87|uniprotkb:Q7Z3K8|uniprotkb:Q8IWF1|intact:EBI-2555229|ensembl:ENSP00000361658	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu188_human(display_long)|uniprotkb:NUP188(gene name)|psi-mi:NUP188(display_short)|uniprotkb:KIAA0169(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056169.1|ensembl:ENSG00000095319(gene)|ensembl:ENST00000372577(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018864|interpro:IPR044840|mint:Q5SRE5|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eoj+tg9RAVKcVlT9ku1ozXCa3u89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54920	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-749652|uniprotkb:Q96IK3|uniprotkb:Q9BVJ3|uniprotkb:A8K879|ensembl:ENSP00000263354	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snaa_human(display_long)|uniprotkb:N-ethylmaleimide-sensitive factor attachment protein alpha(gene name synonym)|uniprotkb:NAPA(gene name)|psi-mi:NAPA(display_short)|uniprotkb:SNAPA(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003818.2|ensembl:ENSG00000105402(gene)|ensembl:ENST00000263354(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005483"(soluble NSF attachment protein activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007420"(brain development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031201"(SNARE complex)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000744(NSF attachment protein)|interpro:IPR011990(Tetratricopeptide-like helical)|reactome:R-HSA-204005|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RHbBvhRSSaakY4HPkl3Y9ggkiPk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52272	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08754	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357563|uniprotkb:Q5TZX1|uniprotkb:P17539|ensembl:ENSP00000358867	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gnai3_human(display_long)|uniprotkb:GNAI3(gene name)|psi-mi:GNAI3(display_short)|uniprotkb:"G(i) alpha-3"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006487.1|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|ensembl:ENSG00000065135(gene)|ensembl:ENST00000369851(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:2IHB|rcsb pdb:2ODE|rcsb pdb:2V4Z|rcsb pdb:4G5O|rcsb pdb:4G5R|rcsb pdb:4G5S|rcsb pdb:7E9H|rcsb pdb:7KH0|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9009391|reactome:R-HSA-9660821	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:npLeIXVzrV8y0trCCII5rivIRYQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49458	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350743|uniprotkb:Q6NVX0|uniprotkb:Q8WTW0|ensembl:ENSP00000305230|uniprotkb:A8K0N0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srp09_human(display_long)|uniprotkb:SRP9(gene name)|psi-mi:SRP9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4UYJ|refseq:NP_001123912.1|refseq:NP_003124.1|ensembl:ENSG00000143742(gene)|ensembl:ENST00000304786(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005785"(signal recognition particle receptor complex)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0045900"(negative regulation of translational elongation)|interpro:IPR008832(Signal recognition particle, SRP9 subunit)|interpro:IPR009018(Signal recognition particle, SRP9/SRP14 subunit)|interpro:IPR039432|interpro:IPR039914|mint:P49458|rcsb pdb:1E8O|rcsb pdb:1E8S|rcsb pdb:1RY1|rcsb pdb:4UYK|rcsb pdb:5AOX|rcsb pdb:7NFX|reactome:R-HSA-1799339|dip:DIP-6151N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y33fEeeXnma9oF7Fzs6zEGQjVBU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22061	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353343|uniprotkb:Q14661|uniprotkb:Q16556|uniprotkb:Q5VYC1|uniprotkb:Q5VYC2|uniprotkb:Q93061|uniprotkb:Q96II9|uniprotkb:Q99625|uniprotkb:Q9BQV7|uniprotkb:Q9BQV8|uniprotkb:Q9NP03|uniprotkb:A8K109|intact:EBI-2551555|uniprotkb:J3KP72|ensembl:ENSP00000356348|ensembl:ENSP00000420813	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pimt_human(display_long)|uniprotkb:PCMT1(gene name)|psi-mi:PCMT1(display_short)|uniprotkb:Protein-beta-aspartate methyltransferase(gene name synonym)|uniprotkb:Protein L-isoaspartyl/D-aspartyl methyltransferase(gene name synonym)|uniprotkb:L-isoaspartyl protein carboxyl methyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001238978.1|refseq:NP_001238982.1|ensembl:ENSG00000120265(gene)|ensembl:ENST00000367378(transcript)|ensembl:ENST00000464889(transcript)|go:"GO:0004719"("protein-L-isoaspartate (D-aspartate) O-methyltransferase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0030091"(protein repair)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000682("Protein-L-isoaspartate(D-aspartate) O-methyltransferase")|interpro:IPR029063|mint:P22061|rcsb pdb:1I1N|rcsb pdb:1KR5|reactome:R-HSA-5676934|refseq:NP_005380.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wfsjVloc3sqDMXlvFAXQI6Fjilw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48729	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1383726|uniprotkb:Q96HD2|uniprotkb:Q5U046|uniprotkb:Q5U047|uniprotkb:Q6FGA2|uniprotkb:Q4JJA0|uniprotkb:Q9UDK3|intact:EBI-11048253|uniprotkb:D3DQG0|uniprotkb:D3DQG1|uniprotkb:Q71TU5|ensembl:ENSP00000367074	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kc1a_human(display_long)|uniprotkb:CSNK1A1(gene name)|psi-mi:CSNK1A1(display_short)|uniprotkb:CK1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001020276.1|refseq:NP_001883.4|refseq:NP_001258670.1|refseq:NP_001258671.1|dip:DIP-40367N|ensembl:ENSG00000113712(gene)|ensembl:ENST00000377843(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904424"(regulation of GTP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48729|rcsb pdb:5FQD|rcsb pdb:6GZD|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5635838	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2rG1/sMVnsRKUEWsLhLAyHvqPnY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13151	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724092|ensembl:ENSP00000316042|intact:EBI-1043661|uniprotkb:Q6IB18	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa0_human(display_long)|uniprotkb:HNRPA0(gene name synonym)|uniprotkb:HNRNPA0(gene name)|psi-mi:HNRNPA0(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006796.1|ensembl:ENSG00000177733(gene)|ensembl:ENST00000314940(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034801|interpro:IPR035979|mint:Q13151|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:buyQxR8FLxd4N6jRhwVsroeGrBw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61026	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-726075|uniprotkb:O88386|uniprotkb:Q6IA52|uniprotkb:Q9D7X6|uniprotkb:Q9H0T3|uniprotkb:D6W538|ensembl:ENSP00000264710	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab10_human(display_long)|uniprotkb:RAB10(gene name)|psi-mi:RAB10(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057215.3|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:5LPN|rcsb pdb:5SZJ|reactome:R-HSA-1445148|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000084733(gene)|ensembl:ENST00000264710(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:F2Z393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190784|ensembl:ENSP00000437098	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:f2z393_human(display_long)|uniprotkb:TALDO1(gene name)|psi-mi:TALDO1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000177156(gene)|ensembl:ENST00000528097(transcript)|go:"GO:0004801"(transaldolase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|interpro:IPR001585(Transaldolase)|interpro:IPR004730(Transaldolase AB)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR018225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HsQeEQ7VSDjAj16nSteErpQ1F309606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26368	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742339|uniprotkb:Q96HC5|intact:EBI-946034|ensembl:ENSP00000307863	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u2af2_human(display_long)|uniprotkb:U2AF2(gene name)|psi-mi:U2AF2(display_short)|uniprotkb:U2AF65(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor large subunit(gene name synonym)|uniprotkb:U2 auxiliary factor 65 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|refseq:NP_001012496.1|refseq:NP_009210.1|ensembl:ENSG00000063244(gene)|ensembl:ENST00000308924(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|rcsb pdb:2HZC|rcsb pdb:2M0G|rcsb pdb:2U2F|rcsb pdb:2YH0|rcsb pdb:2YH1|rcsb pdb:3VAF|rcsb pdb:3VAG|rcsb pdb:3VAH|rcsb pdb:3VAI|rcsb pdb:3VAJ|rcsb pdb:3VAK|rcsb pdb:3VAL|rcsb pdb:3VAM|rcsb pdb:4FXW|rcsb pdb:4TU7|rcsb pdb:4TU8|rcsb pdb:4TU9|rcsb pdb:5EV1|rcsb pdb:5EV2|rcsb pdb:5EV3|rcsb pdb:5EV4|rcsb pdb:5W0G|rcsb pdb:5W0H|rcsb pdb:6TR0|rcsb pdb:6XLV|rcsb pdb:6XLW|rcsb pdb:6XLX|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:2G4B|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006529(U2 snRNP auxilliary factor, large subunit, splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P26368|rcsb pdb:1JMT|rcsb pdb:1O0P|rcsb pdb:1OPI|rcsb pdb:1U2F|go:"GO:0005654"(nucleoplasm)|dip:DIP-2154N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HBYwOej94CoGGN7vPbk0AnbO61Q9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31040	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P98179	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2949699|ensembl:ENSP00000365946|ensembl:ENSP00000365950	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm3_human(display_long)|uniprotkb:RBM3(gene name)|psi-mi:RBM3(display_short)|uniprotkb:RNPL(gene name synonym)|uniprotkb:RNA-binding motif protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030425"(dendrite)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:P98179|go:"GO:0006417"(regulation of translation)|ensembl:ENSG00000102317(gene)|ensembl:ENST00000376755(transcript)|ensembl:ENST00000376759(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|refseq:NP_006734.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+KPnDlgXy+KGVDjTilKMXb5dJGs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05787	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297852|uniprotkb:Q14099|uniprotkb:Q14716|uniprotkb:Q14717|uniprotkb:Q53GJ0|uniprotkb:Q6DHW5|uniprotkb:Q6GMY0|uniprotkb:Q6P4C7|uniprotkb:Q96J60|ensembl:ENSP00000293308|ensembl:ENSP00000447402|ensembl:ENSP00000447566|uniprotkb:A8K4H3|uniprotkb:B0AZN5|uniprotkb:F8VXB4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c8_human(display_long)|uniprotkb:Keratin-8(gene name synonym)|uniprotkb:KRT8(gene name)|psi-mi:KRT8(display_short)|uniprotkb:CYK8(gene name synonym)|uniprotkb:Cytokeratin-8(gene name synonym)|uniprotkb:Type-II keratin Kb8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243222.1|ensembl:ENSG00000170421(gene)|ensembl:ENST00000293308(transcript)|ensembl:ENST00000546897(transcript)|ensembl:ENST00000552551(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030018"(Z disc)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051707"(response to other organism)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P05787|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_002264.1|dip:DIP-424N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zyV8eOjx426ehjJYK4jsizORUws9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12905	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357925|uniprotkb:A6NDB0|uniprotkb:Q5SR10|uniprotkb:Q5SR11|uniprotkb:Q7L7R3|uniprotkb:Q9BWD4|uniprotkb:Q9P1N0|uniprotkb:B2R8G7|ensembl:ENSP00000355011	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ilf2_human(display_long)|uniprotkb:PRO3063(orf name)|uniprotkb:NF45(gene name synonym)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004506.2|refseq:NP_001254738.1|ensembl:ENSG00000143621(gene)|ensembl:ENST00000361891(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q12905|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O76021	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358028|uniprotkb:Q2M1T7|uniprotkb:Q6PL22|uniprotkb:Q8IWS7|uniprotkb:Q8WUZ1|uniprotkb:Q9HDA9|uniprotkb:Q9Y3Z9|uniprotkb:B4DJ58|uniprotkb:D3DUG7|ensembl:ENSP00000460871	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl1d1_human(display_long)|uniprotkb:RSL1D1(gene name)|psi-mi:RSL1D1(display_short)|uniprotkb:CSIG(gene name synonym)|uniprotkb:PBK1(gene name synonym)|uniprotkb:CATX11(gene name synonym)|uniprotkb:L12(orf name)|uniprotkb:Cellular senescence-inhibited gene protein(gene name synonym)|uniprotkb:Protein PBK1(gene name synonym)|uniprotkb:CATX-11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056474.2|ensembl:ENSG00000171490(gene)|ensembl:ENST00000571133(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030686"(90S preribosome)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023674|interpro:IPR028364|mint:O76021	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/mAkpodrvvZA6mz3M8VwHDEJzKo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96AE4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711404|uniprotkb:Q12828|ensembl:ENSP00000359804	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp1_human(display_long)|uniprotkb:FUBP1(gene name)|psi-mi:FUBP1(display_short)|uniprotkb:DNA helicase V(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q96AE4|rcsb pdb:1J4W|rcsb pdb:2KXH|rcsb pdb:4LIJ|rcsb pdb:6Y24|rcsb pdb:6Y2C|rcsb pdb:6Y2D|ensembl:ENSG00000162613(gene)|ensembl:ENST00000370768(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|refseq:NP_003893.2|refseq:NP_001290362.1|refseq:XP_016858232.1|dip:DIP-47273N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:38IaQgYv8qLMAryXO0lbfzgjjsM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07384	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1542113|uniprotkb:Q2TTR0|uniprotkb:Q6DHV4|ensembl:ENSP00000279247|ensembl:ENSP00000431686|ensembl:ENSP00000431984|ensembl:ENSP00000434176|ensembl:ENSP00000435272	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:can1_human(display_long)|uniprotkb:CAPN1(gene name)|psi-mi:CAPN1(display_short)|uniprotkb:CANPL1(gene name synonym)|uniprotkb:Calpain-1 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 1(gene name synonym)|uniprotkb:Calpain mu-type(gene name synonym)|uniprotkb:Micromolar-calpain(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 30 protein(gene name synonym)|uniprotkb:PIG30(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_006718761.1|refseq:NP_001185797.1|refseq:NP_001185798.1|refseq:NP_005177.2|refseq:XP_011543594.1|ensembl:ENSG00000014216(gene)|ensembl:ENST00000279247(transcript)|ensembl:ENST00000524773(transcript)|ensembl:ENST00000527323(transcript)|ensembl:ENST00000533129(transcript)|ensembl:ENST00000533820(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0060056"(mammary gland involution)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097264"(self proteolysis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029643|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P07384|rcsb pdb:1ZCM|rcsb pdb:2ARY|reactome:R-HSA-1474228|reactome:R-HSA-6798695|reactome:R-HSA-6809371|reactome:R-HSA-8862803	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hLf5vu04E7/yonXBb9VIZThbcxk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P56192	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25786	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359352|uniprotkb:Q9BRV9|uniprotkb:A8K400|uniprotkb:Q53YE8|ensembl:ENSP00000379676	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa1_human(display_long)|uniprotkb:PSMA1(gene name)|psi-mi:PSMA1(display_short)|uniprotkb:PROS30(gene name synonym)|uniprotkb:PSC2(gene name synonym)|uniprotkb:Proteasome component C2(gene name synonym)|uniprotkb:Macropain subunit C2(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C2(gene name synonym)|uniprotkb:Proteasome nu chain(gene name synonym)|uniprotkb:30 kDa prosomal protein(gene name synonym)|uniprotkb:HC2(gene name synonym)|uniprotkb:NU(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002777.1|refseq:NP_683877.1|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000129084(gene)|ensembl:ENST00000396394(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002376"(immune system process)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035144|mint:P25786|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|dip:DIP-29369N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tAADzZ1G9E/0BBeS8vybNx97v7k9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14744	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351098|uniprotkb:Q6IBR1|uniprotkb:A8MZ91|uniprotkb:Q9UKH1|uniprotkb:B5BU10|uniprotkb:D3DS33|ensembl:ENSP00000319169|uniprotkb:A8MTP3|uniprotkb:B4DX49|uniprotkb:B4DY30|uniprotkb:E2QRE7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anm5_human(display_long)|uniprotkb:PRMT5(gene name)|psi-mi:PRMT5(display_short)|uniprotkb:IBP72(gene name synonym)|uniprotkb:JBP1(gene name synonym)|uniprotkb:HRMT1L5(gene name synonym)|uniprotkb:Shk1 kinase-binding protein 1 homolog(gene name synonym)|uniprotkb:Jak-binding protein 1(gene name synonym)|uniprotkb:72 kDa ICln-binding protein(gene name synonym)|uniprotkb:SKB1(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001034708.1|refseq:NP_006100.2|refseq:NP_001269882.1|refseq:NP_001269884.1|refseq:NP_001269885.1|ensembl:ENSG00000100462(gene)|ensembl:ENST00000324366(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000785"(chromatin)|go:"GO:0002039"(p53 binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034709"(methylosome)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035243"(protein-arginine omega-N symmetric methyltransferase activity)|go:"GO:0035246"(peptidyl-arginine N-methylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0097421"(liver regeneration)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR007857(Skb1 methyltransferase)|interpro:IPR025799|interpro:IPR029063|interpro:IPR035075|interpro:IPR035247|interpro:IPR035248|mint:O14744|rcsb pdb:4GQB|rcsb pdb:4X60|rcsb pdb:4X61|rcsb pdb:4X63|rcsb pdb:5C9Z|rcsb pdb:5EMJ|rcsb pdb:5EMK|rcsb pdb:5EML|rcsb pdb:5EMM|rcsb pdb:5FA5|rcsb pdb:6CKC|rcsb pdb:6K1S|rcsb pdb:6RLL|rcsb pdb:6RLQ|rcsb pdb:6UGH|rcsb pdb:6UXX|rcsb pdb:6UXY|rcsb pdb:6V0N|rcsb pdb:6V0O|rcsb pdb:6V0P|rcsb pdb:7KIB|rcsb pdb:7KIC|rcsb pdb:7KID|rcsb pdb:7L1G|rcsb pdb:7M05|reactome:R-HSA-191859|reactome:R-HSA-3214858|reactome:R-HSA-6804760|go:"GO:1904992"(positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway)|dip:DIP-33172N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:EwePjCDiU/fiuKOO+wnoYQ8I57I9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04083	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354007|ensembl:ENSP00000257497|ensembl:ENSP00000366109|uniprotkb:B5BU38	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anxa1_human(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:LPC1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000691.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|ensembl:ENSG00000135046(gene)|ensembl:ENST00000257497(transcript)|ensembl:ENST00000376911(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|refseq:XP_011516911.1|dip:DIP-32875N|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P04083|rcsb pdb:1AIN|rcsb pdb:1BO9|rcsb pdb:1QLS|rcsb pdb:5VFW|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-445355|reactome:R-HSA-6785807|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QKmqz+UsAof35B/so2qKLQjn2v09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6M1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1024419|intact:EBI-1059063|intact:EBI-1237206|uniprotkb:A0A4Z0|uniprotkb:B3FTN2|uniprotkb:B3FTN3|uniprotkb:B3FTN4|ensembl:ENSP00000371634	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2b2_human(display_long)|uniprotkb:IGF-II mRNA-binding protein 2(gene name synonym)|uniprotkb:Hepatocellular carcinoma autoantigen p62(gene name synonym)|uniprotkb:VICKZ family member 2(gene name synonym)|uniprotkb:IGF2BP2(gene name)|psi-mi:IGF2BP2(display_short)|uniprotkb:IMP2(gene name synonym)|uniprotkb:VICKZ2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001278801.1|refseq:NP_001278802.1|refseq:NP_001278803.1|refseq:NP_001278804.1|refseq:NP_001007226.1|refseq:NP_006539.3|ensembl:ENSG00000073792(gene)|ensembl:ENST00000382199(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR028743|interpro:IPR034843|interpro:IPR035979|interpro:IPR036612|mint:Q9Y6M1|rcsb pdb:2CQH|rcsb pdb:6ROL|reactome:R-HSA-428359|dip:DIP-35539N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k45UViReMAxCv2cu7+tx+auevQc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P68032	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352273|uniprotkb:P04270|ensembl:ENSP00000290378	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:actc_human(display_long)|uniprotkb:ACTC1(gene name)|psi-mi:ACTC1(display_short)|uniprotkb:ACTC(gene name synonym)|uniprotkb:Alpha-cardiac actin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005150.1|ensembl:ENSG00000159251(gene)|ensembl:ENST00000290378(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0033275"(actin-myosin filament sliding)|go:"GO:0042493"|go:"GO:0044297"(cell body)|go:"GO:0045471"(response to ethanol)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68032|reactome:R-HSA-390522|reactome:R-HSA-8980692|reactome:R-HSA-9013026	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:U/lKYqWUWMSC3fBHFaAcgzfk+3w9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62277	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351850|uniprotkb:P19116|uniprotkb:Q02546|uniprotkb:Q29200|uniprotkb:Q498Y0|uniprotkb:B2R549|ensembl:ENSP00000435777	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs13_human(display_long)|uniprotkb:RPS13(gene name)|psi-mi:RPS13(display_short)|uniprotkb:Small ribosomal subunit protein uS15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008.1|ensembl:ENSG00000110700(gene)|ensembl:ENST00000525634(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000589(Ribosomal protein S15)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR012606(Ribosomal protein S13/S15, N-terminal)|interpro:IPR023029|mint:P62277|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6OM7|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GmlWYkXKxX6YwpEtzNABb+ZcytI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28331-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190702|ensembl:ENSP00000392709|ensembl:ENSP00000490092	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p28331-2(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000455934(transcript)|ensembl:ENST00000637733(transcript)|intact:EBI-1043922(isoform-parent)|uniprotkb:P28331-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kKrRPFU4CRdHw5sNtWXMEoWgMEI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15102	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711522|uniprotkb:Q53X88|ensembl:ENSP00000262890|ensembl:ENSP00000444935	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pa1b3_human(display_long)|uniprotkb:PAFAH1B3(gene name)|psi-mi:PAFAH1B3(display_short)|uniprotkb:PAFAHG(gene name synonym)|uniprotkb:PAF acetylhydrolase 29 kDa subunit(gene name synonym)|uniprotkb:PAF-AH subunit gamma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016042"(lipid catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|interpro:IPR013830(Esterase, SGNH hydrolase-type)|interpro:IPR036514|mint:Q15102|reactome:R-HSA-6811436|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0016020"(membrane)|ensembl:ENSG00000079462(gene)|ensembl:ENST00000262890(transcript)|ensembl:ENST00000538771(transcript)|go:"GO:0003847"(1-alkyl-2-acetylglycerophosphocholine esterase activity)|go:"GO:0005737"(cytoplasm)|refseq:NP_001139411.1|refseq:NP_001139412.1|refseq:NP_002564.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yxVKkXAs2AmH+fZFUW+hZN889k89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O94979	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1767898|uniprotkb:Q17RR5|uniprotkb:Q5H9P6|uniprotkb:Q5XG74|uniprotkb:Q659G7|uniprotkb:Q6ZU90|uniprotkb:Q7LCX9|uniprotkb:Q86TJ0|uniprotkb:Q8IZH4|uniprotkb:Q9P048|uniprotkb:Q9P0A6|uniprotkb:Q9UM05|uniprotkb:Q9UM06|uniprotkb:B7ZKZ7|uniprotkb:B7ZL00|uniprotkb:B4DIW6|uniprotkb:H7C2W3|ensembl:ENSP00000347329|ensembl:ENSP00000378721|ensembl:ENSP00000400926	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc31a_human(display_long)|uniprotkb:SEC31A(gene name)|psi-mi:SEC31A(display_short)|uniprotkb:KIAA0905(gene name synonym)|uniprotkb:SEC31L1(gene name synonym)|uniprotkb:HSPC275(orf name)|uniprotkb:HSPC334(orf name)|uniprotkb:SEC31-related protein A(gene name synonym)|uniprotkb:SEC31-like protein 1(gene name synonym)|uniprotkb:ABP125(gene name synonym)|uniprotkb:ABP130(gene name synonym)|uniprotkb:Web1-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070674.1|refseq:NP_001070675.1|refseq:NP_001070676.1|refseq:NP_057295.2|refseq:NP_001305048.1|refseq:NP_001305049.1|refseq:NP_001287673.1|refseq:NP_001287674.1|refseq:NP_001177978.1|dip:DIP-40438N|ensembl:ENSG00000138674(gene)|ensembl:ENST00000355196(transcript)|ensembl:ENST00000395310(transcript)|ensembl:ENST00000448323(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024298|interpro:IPR036322|interpro:IPR040251|mint:O94979|rcsb pdb:3WXA|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-381038|reactome:R-HSA-983170	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MvtQi/4RmQ0siNtNoYH6k1rPv1Y9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19623	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056183|uniprotkb:Q15511|uniprotkb:B1AKP9|ensembl:ENSP00000366156	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:spee_human(display_long)|uniprotkb:SRM(gene name)|psi-mi:SRM(display_short)|uniprotkb:SPS1(gene name synonym)|uniprotkb:SRML1(gene name synonym)|uniprotkb:Putrescine aminopropyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003123.2|ensembl:ENSG00000116649(gene)|ensembl:ENST00000376957(transcript)|go:"GO:0004766"(spermidine synthase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0006596"(polyamine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001045(Spermine synthase)|interpro:IPR029063|interpro:IPR030373|interpro:IPR030374|interpro:IPR030668|interpro:IPR035246|interpro:IPR037163|rcsb pdb:2O05|rcsb pdb:2O06|rcsb pdb:2O07|rcsb pdb:2O0L|rcsb pdb:3RW9|reactome:R-HSA-351202	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VNjR3N2SwRzXIokl23Lis1pV3Pg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02538	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6190532	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	-	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c9j6d7_human(display_short)|psi-mi:EBI-6190532(display_long)|uniprotkb:KIAA0664(gene name)|psi-mi:KIAA0664(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	uniprotkb:C9J6D7(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vIKw9yo22CTfO4A1eK7NsIpcGkI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5T4S7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1995940|intact:EBI-1059327|uniprotkb:A8MPT2|uniprotkb:A8MQ33|uniprotkb:A8MQB1|uniprotkb:O60646|uniprotkb:O75050|uniprotkb:Q4QRK5|uniprotkb:Q5T4S8|uniprotkb:Q5T4S9|uniprotkb:Q5TBN8|uniprotkb:Q5TBP2|uniprotkb:Q6DKH8|uniprotkb:Q6P4A4|uniprotkb:Q7L8P7|uniprotkb:Q8IXJ4|uniprotkb:Q8TDN5|uniprotkb:Q8WV67|uniprotkb:Q9HA46|uniprotkb:Q9P2N9|uniprotkb:Q9UG82|ensembl:ENSP00000364403	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubr4_human(display_long)|uniprotkb:UBR4(gene name)|psi-mi:UBR4(display_short)|uniprotkb:KIAA0462(gene name synonym)|uniprotkb:KIAA1307(gene name synonym)|uniprotkb:RBAF600(gene name synonym)|uniprotkb:ZUBR1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:Retinoblastoma-associated factor of 600 kDa(gene name synonym)|uniprotkb:600 kDa retinoblastoma protein-associated factor(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065816.2|ensembl:ENST00000375218|ensembl:ENSP00000364403|ensembl:ENSP00000364366|ensembl:ENSG00000127481(gene)|ensembl:ENST00000375254(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:Q5T4S7|reactome:R-HSA-6798695|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Iown8oj965YAir+95+3om5+1YM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62847	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354515|uniprotkb:P16632|uniprotkb:Q7Z3D1|uniprotkb:Q5T0P7|uniprotkb:Q5T0P8|uniprotkb:E7EPK6|ensembl:ENSP00000478869	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs24_human(display_long)|uniprotkb:RPS24(gene name)|psi-mi:RPS24(display_short)|uniprotkb:Small ribosomal subunit protein eS24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001135757.1|refseq:NP_001017.1|refseq:NP_001135755.1|refseq:NP_148982.1|ensembl:ENSG00000138326(gene)|ensembl:ENST00000613865(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001976(Ribosomal protein S24e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR018098|mint:P62847|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6XA1|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M/qkRxabHx9PFaOM7EwKDOOwu7Q9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96I24	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-954200|ensembl:ENSP00000318177|uniprotkb:Q92946|uniprotkb:Q9BVB6|intact:EBI-1760333|intact:EBI-1965411|uniprotkb:A3KFL0|uniprotkb:A3KFK8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp3_human(display_long)|uniprotkb:FUBP3(gene name)|psi-mi:FUBP3(display_short)|uniprotkb:FBP3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000107164(gene)|ensembl:ENST00000319725(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q96I24|refseq:NP_003925.1|dip:DIP-50124N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xdCa+teqFaSxKNTpCJWQ5gcd0sQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04632	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711828|uniprotkb:Q8WTX3|uniprotkb:Q96EW0|uniprotkb:A8K0P1|ensembl:ENSP00000246533|ensembl:ENSP00000464849	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpns1_human(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:CAPNS1(gene name)|psi-mi:CAPNS1(display_short)|uniprotkb:CAPN4(gene name synonym)|uniprotkb:CAPNS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000126247(gene)|ensembl:ENST00000246533(transcript)|ensembl:ENST00000588815(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|mint:P04632|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:4PHJ|rcsb pdb:4PHK|rcsb pdb:4PHM|rcsb pdb:4WQ2|rcsb pdb:4WQ3|rcsb pdb:5D69|rcsb pdb:6QLB|reactome:R-HSA-1474228|reactome:R-HSA-6809371|reactome:R-HSA-8862803|refseq:NP_001003962.1|refseq:NP_001740.1|refseq:NP_001289561.1|refseq:NP_001289562.1|refseq:XP_005259352.1|refseq:XP_005259353.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:siQugDvaWq0YjOr8qOCf0BsRRKs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31946	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43243	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352602|ensembl:ENSP00000378284|ensembl:ENSP00000482895|uniprotkb:Q9UHW0|uniprotkb:Q9UQ27|uniprotkb:D3DQC3|uniprotkb:B7ZAV5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:matr3_human(display_long)|uniprotkb:KIAA0723(gene name synonym)|uniprotkb:MATR3(gene name)|psi-mi:MATR3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000015479(gene)|ensembl:ENST00000394805(transcript)|ensembl:ENST00000618441(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:P43243|refseq:NP_001181883.1|refseq:NP_001181884.1|refseq:NP_061322.2|refseq:NP_954659.1|refseq:NP_001181885.1|refseq:NP_001269207.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3UZlyCZHgdr1SBgUctv9Ev7XBSQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49721	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359335|uniprotkb:P31145|uniprotkb:Q9BWZ9|uniprotkb:D3DPS0|ensembl:ENSP00000362334	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb2_human(display_long)|uniprotkb:PSMB2(gene name)|psi-mi:PSMB2(display_short)|uniprotkb:Multicatalytic endopeptidase complex subunit C7-I(gene name synonym)|uniprotkb:Proteasome component C7-I(gene name synonym)|uniprotkb:Macropain subunit C7-I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002785.1|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5GJR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-5689603|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000126067(gene)|ensembl:ENST00000373237(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035206|mint:P49721|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|dip:DIP-33848N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PvXrk6RLayQ1zqmavn1cONfA9/A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75489	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408	-	-	crc64:C058D62779BEF17B	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22234	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712261|ensembl:ENSP00000264221|ensembl:ENSP00000421096|uniprotkb:E9PDH9|uniprotkb:Q68CQ5|intact:EBI-21352784	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pur6_human(display_long)|uniprotkb:PAICS(gene name)|psi-mi:PAICS(display_short)|uniprotkb:ADE2(gene name synonym)|uniprotkb:AIRC(gene name synonym)|uniprotkb:PAIS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000128050(gene)|ensembl:ENST00000264221(transcript)|ensembl:ENST00000512576(transcript)|go:"GO:0004639"(phosphoribosylaminoimidazolesuccinocarboxamide synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043727"(5-amino-4-imidazole carboxylate lyase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000031("1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase")|interpro:IPR018236|interpro:IPR028923|interpro:IPR033626|mint:P22234|rcsb pdb:2H31|rcsb pdb:6YB8|go:"GO:0004638"(phosphoribosylaminoimidazole carboxylase activity)|rcsb pdb:6YB9|reactome:R-HSA-73817|refseq:NP_001072992.1|refseq:NP_001072993.1|refseq:NP_006443.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aR4Xj14ZQrPiY8cldw5o9AvjkAo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62263	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352783|ensembl:ENSP00000311028|ensembl:ENSP00000385425|uniprotkb:P06366|uniprotkb:Q5BJI0|uniprotkb:B2R5G5|uniprotkb:D3DQG5|ensembl:ENSP00000385958|ensembl:ENSP00000428509	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs14_human(display_long)|uniprotkb:RPS14(gene name)|psi-mi:RPS14(display_short)|uniprotkb:Small ribosomal subunit protein uS11(gene name synonym)|uniprotkb:PRO2640(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164587(gene)|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001020242.1|refseq:NP_005608.1|refseq:NP_001020241.1|ensembl:ENST00000312037(transcript)|ensembl:ENST00000401695(transcript)|ensembl:ENST00000407193(transcript)|ensembl:ENST00000521466(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P62263|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ee3bJ5JYFaZXyCCRG9Wooopyz2o9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78527	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32322	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30153	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16891	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38646	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27708	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355504|uniprotkb:Q6P0Q0|uniprotkb:D6W552|ensembl:ENSP00000264705|uniprotkb:Q96CK3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pyr1_human(display_long)|uniprotkb:CAD(gene name)|psi-mi:CAD(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004332.2|ensembl:ENSG00000084774(gene)|ensembl:ENST00000264705(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070335"(aspartate binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:P27708|go:"GO:0016020"(membrane)|rcsb pdb:4BY3|rcsb pdb:4C6B|rcsb pdb:4C6C|rcsb pdb:4C6D|rcsb pdb:4C6E|rcsb pdb:4C6F|rcsb pdb:4C6I|rcsb pdb:4C6J|rcsb pdb:4C6K|rcsb pdb:4C6L|rcsb pdb:4C6M|rcsb pdb:4C6N|rcsb pdb:4C6O|rcsb pdb:4C6P|rcsb pdb:4C6Q|rcsb pdb:5G1N|rcsb pdb:5G1O|rcsb pdb:5G1P|rcsb pdb:5YNZ|rcsb pdb:6HFD|rcsb pdb:6HFE|rcsb pdb:6HFF|rcsb pdb:6HFH|rcsb pdb:6HFI|rcsb pdb:6HFJ|rcsb pdb:6HFK|rcsb pdb:6HFL|rcsb pdb:6HFP|rcsb pdb:6HFQ|rcsb pdb:6HFR|rcsb pdb:6HFS|rcsb pdb:6HFU|rcsb pdb:6HG1|reactome:R-HSA-500753|rcsb pdb:6HFN|refseq:NP_001293008.1|dip:DIP-39484N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m5iR4BQz6t2dbQxtP1MARVW0LAw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14315	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62316	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297993|uniprotkb:P43330|ensembl:ENSP00000342374|ensembl:ENSP00000465216|uniprotkb:A8K797|uniprotkb:J3KPM5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd2_human(display_long)|uniprotkb:SNRPD2(gene name)|psi-mi:SNRPD2(display_short)|uniprotkb:snRNP core protein D2(gene name synonym)|uniprotkb:SNRPD1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000125743(gene)|ensembl:ENST00000342669(transcript)|ensembl:ENST00000588301(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027248|mint:P62316|rcsb pdb:1B34|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5XJL|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_004588.1|refseq:NP_808210.2|dip:DIP-31219N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4OshNPT6N4dOcWMVXrF5Fm8dcnI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6UY14	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742002|uniprotkb:Q5T5F7|uniprotkb:Q6IPM6|uniprotkb:Q8N643|uniprotkb:Q9HBS6|ensembl:ENSP00000271643|ensembl:ENSP00000358034|uniprotkb:B2RTT0|uniprotkb:F8WAD0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atl4_human(display_long)|uniprotkb:Thrombospondin repeat-containing protein 1(gene name synonym)|uniprotkb:ADAMTSL4(gene name)|psi-mi:ADAMTSL4(display_short)|uniprotkb:TSRC1(gene name synonym)|uniprotkb:PP1396(orf name)|uniprotkb:UNQ2803/PRO34012(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061905.2|refseq:NP_079284.2|ensembl:ENSG00000143382(gene)|ensembl:ENST00000271643(transcript)|ensembl:ENST00000369038(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006915"(apoptotic process)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR036383|mint:Q6UY14|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005576"(extracellular region)|refseq:NP_001275536.1|refseq:NP_001275537.1|refseq:XP_011507950.1|refseq:XP_016856995.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HIXY8OQopS51RVemJo0GTj8V0WQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63244	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14868	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358730|uniprotkb:Q2TNI3|uniprotkb:Q32Q69|uniprotkb:Q53HV4|uniprotkb:Q53YC5|uniprotkb:Q9BW52|uniprotkb:Q68CR9|uniprotkb:A8K3J2|uniprotkb:D3DP77|ensembl:ENSP00000264161	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sydc_human(display_long)|uniprotkb:DARS1(gene name)|psi-mi:DARS1(display_short)|uniprotkb:Aspartyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 40 protein(gene name synonym)|uniprotkb:DARS(gene name synonym)|uniprotkb:PIG40(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001340.2|refseq:NP_001280241.1|ensembl:ENSG00000115866(gene)|ensembl:ENST00000264161(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006422"(aspartyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0045202"(synapse)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004523(Aspartyl-tRNA synthetase, class IIb, archea/euk type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:P14868|rcsb pdb:4J15|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Yzpil/THkSHGR/ixVyQbV3RZz/E9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00233	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750973|uniprotkb:Q9BQ42|uniprotkb:G3V1Q6|uniprotkb:B2RD35|intact:EBI-28988356|ensembl:ENSP00000440485	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd9_human(display_long)|uniprotkb:26S proteasome regulatory subunit p27(gene name synonym)|uniprotkb:PSMD9(gene name)|psi-mi:PSMD9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002804.2|refseq:NP_001248329.1|ensembl:ENST00000537407|ensembl:ENSP00000445058|ensembl:ENSP00000440485|ensembl:ENST00000542602|ensembl:ENSP00000443772|ensembl:ENSG00000110801(gene)|ensembl:ENST00000541212(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0070682"(proteasome regulatory particle assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR035269|interpro:IPR036034|interpro:IPR040815|interpro:IPR041489|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|go:"GO:0003713"(transcription coactivator activity)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OkUTrgO5lFTumVtMd+3vZTf3TPc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7Z5G4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4403685|ensembl:ENSP00000350378|ensembl:ENSP00000429329|ensembl:ENSP00000429480|uniprotkb:D3DSX9|uniprotkb:Q96EQ4|uniprotkb:Q9P1S0|uniprotkb:Q9Y5U7|uniprotkb:J3KQ24	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:goga7_human(display_long)|uniprotkb:GOLGA7(gene name)|psi-mi:GOLGA7(display_short)|uniprotkb:GCP16(gene name synonym)|uniprotkb:Golgi complex-associated protein of 16 kDa(gene name synonym)|uniprotkb:HDCKB03P(orf name)|uniprotkb:HSPC041(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000147533(gene)|ensembl:ENST00000357743(transcript)|ensembl:ENST00000518270(transcript)|ensembl:ENST00000520817(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002178"(palmitoyltransferase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005795"(Golgi stack)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0018230"(peptidyl-L-cysteine S-palmitoylation)|go:"GO:0031228"(intrinsic component of Golgi membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR019383|reactome:R-HSA-6798695|reactome:R-HSA-9648002|refseq:NP_001002296.1|refseq:NP_057183.2|refseq:NP_001167595.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NV93lzMDdykrGhl0NkCKYso0t+A9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P20618	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372273|uniprotkb:Q9BWA8|ensembl:ENSP00000262193|uniprotkb:B5BU76	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb1_human(display_long)|uniprotkb:PSMB1(gene name)|psi-mi:PSMB1(display_short)|uniprotkb:PSC5(gene name synonym)|uniprotkb:Proteasome component C5(gene name synonym)|uniprotkb:Macropain subunit C5(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C5(gene name synonym)|uniprotkb:Proteasome gamma chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000008018(gene)|ensembl:ENST00000262193(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035202|mint:P20618|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5L5B|rcsb pdb:5L5D|rcsb pdb:5L5E|rcsb pdb:5L5F|refseq:NP_002784.1|rcsb pdb:5L5H|rcsb pdb:5L5I|rcsb pdb:5L5J|rcsb pdb:5L5O|rcsb pdb:5L5P|rcsb pdb:5L5Q|rcsb pdb:5L5R|rcsb pdb:5L5S|rcsb pdb:5L5T|rcsb pdb:5L5U|rcsb pdb:5L5V|rcsb pdb:5L5W|rcsb pdb:5L5X|rcsb pdb:5L5Y|rcsb pdb:5L5Z|rcsb pdb:5L60|rcsb pdb:5L61|rcsb pdb:5L62|rcsb pdb:5L63|rcsb pdb:5L64|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M2B|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5LF1|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4608870|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-983168|reactome:R-HSA-9604323|dip:DIP-31193N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DfIS480BUnqbXus9/KoojdkWgw09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08J23	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642839|intact:EBI-2839052|uniprotkb:A8K529|uniprotkb:B3KP09|uniprotkb:G3V1R4|uniprotkb:Q9BVN4|uniprotkb:Q9H858|uniprotkb:Q9NXD9|uniprotkb:B2RNR4|intact:EBI-2556652|uniprotkb:B4DQW2|ensembl:ENSP00000264670	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nsun2_human(display_long)|uniprotkb:NSUN2(gene name)|psi-mi:NSUN2(display_short)|uniprotkb:SAKI(gene name synonym)|uniprotkb:TRM4(gene name synonym)|uniprotkb:NOL1/NOP2/Sun domain family member 2(gene name synonym)|uniprotkb:tRNA methyltransferase 4 homolog(gene name synonym)|uniprotkb:Substrate of AIM1/Aurora kinase B(gene name synonym)|uniprotkb:Myc-induced SUN domain-containing protein(gene name synonym)|uniprotkb:"mRNA cytosine C(5)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA cytosine C(5)-methyltransferase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001180384.1|refseq:NP_060225.4|dip:DIP-52456N|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0006400"(tRNA modification)|go:"GO:0007286"(spermatid development)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016428"("tRNA (cytosine-5-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0033313"(meiotic cell cycle checkpoint signaling)|go:"GO:0033391"(chromatoid body)|go:"GO:0036416"(tRNA stabilization)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051301"(cell division)|go:"GO:0062152"("mRNA (cytidine-5-)-methyltransferase activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0080009"(mRNA methylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR023267|interpro:IPR023270|interpro:IPR029063|mint:Q08J23|reactome:R-HSA-6782315|ensembl:ENSG00000037474(gene)|ensembl:ENST00000264670(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001510"(RNA methylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k3hK/9cjuy5c4PyDGgCt0LsVtdo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08752	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P20700	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-968218|ensembl:ENSP00000261366|uniprotkb:Q3SYN7|uniprotkb:Q96EI6|uniprotkb:B2R6J6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lmnb1_human(display_long)|uniprotkb:LMNB1(gene name)|psi-mi:LMNB1(display_short)|uniprotkb:LMN2(gene name synonym)|uniprotkb:LMNB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000113368(gene)|ensembl:ENST00000261366(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P20700|rcsb pdb:2KPW|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3JT0|rcsb pdb:3TYY|rcsb pdb:3UMN|rcsb pdb:5VVX|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|reactome:R-HSA-2559584|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-4419969|reactome:R-HSA-8862803|reactome:R-HSA-8950505|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:NP_005564.1|dip:DIP-34897N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZLv4OS5VSmn3sdXB9IP98YdQ+Iw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92945	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049099|uniprotkb:O00301|uniprotkb:Q59EZ9|uniprotkb:Q5U4P6|uniprotkb:Q9UNT5|uniprotkb:Q9UQH5|intact:EBI-5455671|ensembl:ENSP00000381216	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp2_human(display_long)|uniprotkb:KH type-splicing regulatory protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:KHSRP(gene name)|psi-mi:KHSRP(display_short)|uniprotkb:FUBP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003676.2|ensembl:ENSG00000088247(gene)|ensembl:ENST00000398148(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q92945|rcsb pdb:2HH2|rcsb pdb:2HH3|rcsb pdb:2JVZ|rcsb pdb:2OPU|rcsb pdb:2OPV|rcsb pdb:4B8T|reactome:R-HSA-380994|reactome:R-HSA-450604|dip:DIP-48484N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hlybJllTqSgPgtwwz3kc12zDYh49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50570	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5JXB2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190823|uniprotkb:E9KL27	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ue2nl_human(display_long)|uniprotkb:Epididymis tissue protein Li 174(gene name synonym)|uniprotkb:UBE2NL(gene name)|psi-mi:UBE2NL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0000209"(protein polyubiquitination)|refseq:NP_001013007.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sh3UsocorMe1c+Y1g5ZEhvrblEk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08107	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92614	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-949059|ensembl:ENSP00000437073|uniprotkb:Q5H9U3|uniprotkb:Q5W9F9|uniprotkb:Q5W9G1|uniprotkb:Q8IXP8|uniprotkb:Q5QD01	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:my18a_human(display_long)|uniprotkb:Myosin containing a PDZ domain(gene name synonym)|uniprotkb:Molecule associated with JAK3 N-terminus(gene name synonym)|uniprotkb:MYO18A(gene name)|psi-mi:MYO18A(display_short)|uniprotkb:KIAA0216(gene name synonym)|uniprotkb:MYSPDZ(gene name synonym)|uniprotkb:CD245(gene name synonym)|uniprotkb:Surfactant protein receptor SP-R210(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	dip:DIP-46631N|ensembl:ENSG00000196535(gene)|ensembl:ENST00000527372(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016477"(cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042641"(actomyosin)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|go:"GO:1903028"(positive regulation of opsonization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR020587|interpro:IPR027417|interpro:IPR031244|interpro:IPR036034|interpro:IPR036064|interpro:IPR036961|interpro:IPR041489|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-9703465|refseq:NP_510880.2|refseq:NP_976063.1|refseq:NP_001333696.1|refseq:NP_001333697.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IunEYt79RO62wU6VU2gv16Xb7Lk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62318	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372789|uniprotkb:P43331|uniprotkb:B5BU13|uniprotkb:B4DJP7|ensembl:ENSP00000215829|intact:EBI-10981086	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd3_human(display_long)|uniprotkb:SNRPD3(gene name)|psi-mi:SNRPD3(display_short)|uniprotkb:snRNP core protein D3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004166.1|refseq:NP_001265585.1|ensembl:ENSG00000100028(gene)|ensembl:ENST00000215829(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:0071209"(U7 snRNA binding)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034099|mint:P62318|rcsb pdb:1D3B|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-111367|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-73856|reactome:R-HSA-77588|rcsb pdb:7ABG|rcsb pdb:3VRI|rcsb pdb:4PJO|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:3PGW|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6V4X|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|dip:DIP-31216N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WkrSZVfVmSQrJYfy7mwp48xjsVA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11586	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709638|uniprotkb:Q86VC9|uniprotkb:Q9BVP5|uniprotkb:B2R5Y2|uniprotkb:G3V2B8|intact:EBI-21358459|uniprotkb:A0A024R652|uniprotkb:A0A384N5Y3|ensembl:ENSP00000498336|ensembl:ENSP00000498511	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c1tc_human(display_long)|uniprotkb:MTHFD1(gene name)|psi-mi:MTHFD1(display_short)|uniprotkb:MTHFC(gene name synonym)|uniprotkb:MTHFD(gene name synonym)|uniprotkb:Epididymis secretory sperm binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005947.3|dip:DIP-33682N|ensembl:ENSG00000100714(gene)|ensembl:ENST00000651537(transcript)|ensembl:ENST00000652337(transcript)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR027417|interpro:IPR036291|mint:P11586|rcsb pdb:1A4I|rcsb pdb:1DIA|rcsb pdb:1DIB|rcsb pdb:1DIG|rcsb pdb:6ECP|rcsb pdb:6ECQ|rcsb pdb:6ECR|reactome:R-HSA-196757	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6ZizfpjVcaL5WNxKXL7qJpw59PI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62136	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55196	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-365875|uniprotkb:O75089|uniprotkb:Q5TIG6|uniprotkb:O75087|uniprotkb:O75088|uniprotkb:Q9NSN7|uniprotkb:Q9NU92|uniprotkb:Q5TIG7|uniprotkb:Q59FP0|ensembl:ENSP00000404595	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:afad_human(display_long)|uniprotkb:AFDN(gene name)|psi-mi:AFDN(display_short)|uniprotkb:AF6(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 6 protein(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:MLLT4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035089.1|refseq:NP_001193937.1|refseq:XP_005267053.1|ensembl:ENST00000392108|ensembl:ENSP00000375956|ensembl:ENST00000392112|ensembl:ENSP00000375960|ensembl:ENST00000400822|ensembl:ENSP00000383623|ensembl:ENSP00000404595|refseq:NP_001278893.1|ensembl:ENSG00000130396(gene)|ensembl:ENST00000447894(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|interpro:IPR036034|interpro:IPR037977|mint:P55196|rcsb pdb:1T2M|rcsb pdb:1XZ9|rcsb pdb:2AIN|rcsb pdb:2EXG|rcsb pdb:5A6C|reactome:R-HSA-418990|go:"GO:0022409"(positive regulation of cell-cell adhesion)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x7kK5K1+wAFZFdVopvQ/l496J5U9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96CW1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00231	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BgQKXK7gMMihacRCI+g/pBnRN309606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09496	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62993	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13148	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09874	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61081	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1041660|uniprotkb:O76069|uniprotkb:Q8VC50|ensembl:ENSP00000253023	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubc12_human(display_long)|uniprotkb:UBE2M(gene name)|psi-mi:UBE2M(display_short)|uniprotkb:UBC12(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 M(gene name synonym)|uniprotkb:NEDD8 carrier protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003960.1|ensembl:ENSG00000130725(gene)|ensembl:ENST00000253023(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61081|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:2NVU|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4GAO|rcsb pdb:4P5O|reactome:R-HSA-2173789|reactome:R-HSA-5607761|reactome:R-HSA-5676590|dip:DIP-35679N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BXJ9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042540|uniprotkb:Q52LG9|uniprotkb:Q8IWH4|uniprotkb:Q8NEV2|uniprotkb:Q9H8P6|uniprotkb:D3DNY6|ensembl:ENSP00000296543	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:naa15_human(display_long)|uniprotkb:NAA15(gene name)|psi-mi:NAA15(display_short)|uniprotkb:GA19(gene name synonym)|uniprotkb:NATH(gene name synonym)|uniprotkb:TBDN100(gene name synonym)|uniprotkb:Gastric cancer antigen Ga19(gene name synonym)|uniprotkb:N-terminal acetyltransferase(gene name synonym)|uniprotkb:Protein tubedown-1(gene name synonym)|uniprotkb:Tbdn100(gene name synonym)|uniprotkb:NARG1(gene name synonym)|uniprotkb:NMDA receptor-regulated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_476516.1|go:"GO:0016604"(nuclear body)|go:"GO:0017196"(N-terminal peptidyl-methionine acetylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031415"(NatA complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR021183|mint:Q9BXJ9|rcsb pdb:6C95|rcsb pdb:6C9M|rcsb pdb:6PPL|rcsb pdb:6PW9|ensembl:ENSG00000164134(gene)|ensembl:ENST00000296543(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006474"(N-terminal protein amino acid acetylation)|go:"GO:0016020"(membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BGW5jQRBYXuf75thzj6cWvL2A5Y9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62280	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047710|uniprotkb:B2R4F5|uniprotkb:P04643|uniprotkb:Q498Y6|uniprotkb:Q6IRY0|ensembl:ENSP00000270625	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs11_human(display_long)|uniprotkb:RPS11(gene name)|psi-mi:RPS11(display_short)|uniprotkb:Small ribosomal subunit protein uS17(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001006.1|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000266(Ribosomal protein S17)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019979|interpro:IPR028333|interpro:IPR032440|mint:P62280|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|go:"GO:0005840"(ribosome)|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|ensembl:ENSG00000142534(gene)|ensembl:ENST00000270625(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6OM0|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0fqJjtWAuz31VTKt2mbteRoi8vA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-395393|uniprotkb:P08918|uniprotkb:P08919|uniprotkb:Q14860|uniprotkb:Q16295|ensembl:ENSP00000266732	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lap2a_human(display_long)|uniprotkb:TMPO(gene name)|psi-mi:TMPO(display_short)|uniprotkb:LAP2(gene name synonym)|uniprotkb:Thymopoietin isoform alpha(gene name synonym)|uniprotkb:Thymopoietin-related peptide isoform alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003267.1|ensembl:ENSG00000120802(gene)|ensembl:ENST00000266732(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0045296"(cadherin binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR013146(Thymopoietin LEM)|interpro:IPR021623|mint:P42166|rcsb pdb:1GJJ|rcsb pdb:1H9E|rcsb pdb:1H9F	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/kq+6sQN9B8jf+Ee4uPj7gtWe509606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62306	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356900|uniprotkb:A2VCR2|uniprotkb:Q15356|uniprotkb:Q6IBQ1|uniprotkb:Q6P4I0|uniprotkb:B2R498|ensembl:ENSP00000266735	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ruxf_human(display_long)|uniprotkb:SNRPF(gene name)|psi-mi:SNRPF(display_short)|uniprotkb:PBSCF(gene name synonym)|uniprotkb:Sm protein F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003086.1|ensembl:ENSG00000139343(gene)|ensembl:ENST00000266735(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|dip:DIP-31221N|rcsb pdb:5XJL|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6V4X|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-111367|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-73856|reactome:R-HSA-77588|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|interpro:IPR034100|mint:P62306|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2RggXu+kFj6wG7gTmxRHOIRvXiM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60660	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-300817|uniprotkb:P16475|uniprotkb:P24572|uniprotkb:P24573|uniprotkb:Q12790|ensembl:ENSP00000446955|ensembl:ENSP00000448101|uniprotkb:Q6IAZ0|uniprotkb:Q6IPY5|uniprotkb:Q561V9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myl6_human(display_long)|uniprotkb:MYL6(gene name)|psi-mi:MYL6(display_short)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6(gene name synonym)|uniprotkb:Myosin light chain alkali 3(gene name synonym)|uniprotkb:Myosin light chain 3(gene name synonym)|uniprotkb:17 kDa myosin light chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000092841(gene)|ensembl:ENST00000548293(transcript)|ensembl:ENST00000550697(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|mint:P60660|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:NP_066299.2|refseq:NP_524147.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LhE3NUqcuHlOla13C0vjnFZfzy89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43487	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1032909|uniprotkb:Q53EY3|ensembl:ENSP00000327583	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rang_human(display_long)|uniprotkb:RANBP1(gene name)|psi-mi:RANBP1(display_short)|uniprotkb:Ran-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002873.1|ensembl:ENSG00000099901(gene)|ensembl:ENST00000331821(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0046907"(intracellular transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1K5D|rcsb pdb:1K5G|reactome:R-HSA-165054|refseq:NP_001265568.1|refseq:NP_001265569.1|dip:DIP-35058N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OWndphaUCDSO3+MGhJqcuQo2Lk09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35658	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13895	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358049|uniprotkb:Q6P5W4|uniprotkb:Q86W44|uniprotkb:Q96IP8|ensembl:ENSP00000230340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:byst_human(display_long)|uniprotkb:BYSL(gene name)|psi-mi:BYSL(display_short)|uniprotkb:ENP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004044.3|dip:DIP-50092N|ensembl:ENSG00000112578(gene)|ensembl:ENST00000230340(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045177"(apical part of cell)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR007955(Bystin)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QdpF9XYm2gFc5ZodqaGvqTM6XNk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49736	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13200	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06576	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N684	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746909|uniprotkb:C9K0Q4|uniprotkb:Q7Z3H9|uniprotkb:Q9H025|uniprotkb:Q9H9V1|uniprotkb:B3KU04|ensembl:ENSP00000378352	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpsf7_human(display_long)|uniprotkb:Cleavage and polyadenylation specificity factor 59 kDa subunit(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 59 kDa subunit(gene name synonym)|uniprotkb:CPSF7(gene name)|psi-mi:CPSF7(display_short)|uniprotkb:Cleavage factor Im complex 59 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129512.1|refseq:NP_001136037.1|refseq:NP_079087.3|refseq:XP_011543560.1|refseq:XP_011543561.1|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0016020"(membrane)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034770|interpro:IPR034772|interpro:IPR034773|interpro:IPR035979|mint:Q8N684|rcsb pdb:3N9U|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|ensembl:ENSG00000149532(gene)|ensembl:ENST00000394888(transcript)|refseq:XP_005274356.1|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfliZhw27GRZMSQpYRZ/x/tWGh49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13242	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2949710|ensembl:ENSP00000229390|uniprotkb:Q52LD1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf9_human(display_long)|uniprotkb:SRSF9(gene name)|psi-mi:SRSF9(display_short)|uniprotkb:SFRS9(gene name synonym)|uniprotkb:SRP30C(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30C(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006397"(mRNA processing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0006376"(mRNA splice site selection)|interpro:IPR034503|interpro:IPR034995|interpro:IPR035979|mint:Q13242|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|ensembl:ENSG00000111786(gene)|ensembl:ENST00000229390(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_003760.1|dip:DIP-40741N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9x6TWFk1zN1YodjXBiwi/MtNJe49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60610	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60493	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727209|uniprotkb:Q4TT31|uniprotkb:O60718|uniprotkb:Q5JXJ7|uniprotkb:Q5JXJ8|uniprotkb:Q96AP9|uniprotkb:Q9C0J5|uniprotkb:Q9NU45|intact:EBI-1056609|uniprotkb:A8K0B1|uniprotkb:Q4TT29|uniprotkb:E1P5E4|uniprotkb:E1P5E5|ensembl:ENSP00000230085	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snx3_human(display_long)|uniprotkb:Protein SDP3(gene name synonym)|uniprotkb:SNX3(gene name)|psi-mi:SNX3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003786.1|refseq:NP_690040.1|refseq:NP_001287858.1|ensembl:ENSG00000112335(gene)|ensembl:ENST00000230085(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1905394"(retromer complex binding)|go:"GO:2000642"(negative regulation of early endosome to late endosome transport)|interpro:IPR001683(Phox-like)|interpro:IPR036871|interpro:IPR042137|rcsb pdb:2MXC|rcsb pdb:2YPS|rcsb pdb:5F0J|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:7BLO|reactome:R-HSA-3238698|reactome:R-HSA-5689880	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M/QKs79zhWobkEdFuxrJTnrrUes9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99623	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:h4pib54mBeQgOKCe/hib58LM26w9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52292	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-349938|uniprotkb:Q9BRU5|ensembl:ENSP00000504685|intact:EBI-28977049|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|uniprotkb:B9EJD6|uniprotkb:Q53YE3|intact:EBI-9377406|uniprotkb:Q6NVW7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ima1_human(display_long)|uniprotkb:KPNA2(gene name)|psi-mi:KPNA2(display_short)|uniprotkb:RCH1(gene name synonym)|uniprotkb:SRP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002257.1|refseq:NP_001307540.1|ensembl:ENST00000330459(transcript)|ensembl:ENST00000537025(transcript)|ensembl:ENST00000579754(transcript)|ensembl:ENST00000584026(transcript)|ensembl:ENST00000677086(transcript)|ensembl:ENST00000679078(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52292|rcsb pdb:1EFX|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:3FEX|ensembl:ENSG00000182481(gene)|rcsb pdb:3FEY|rcsb pdb:3WPT|rcsb pdb:4E4V|rcsb pdb:4WV6|rcsb pdb:5H43|rcsb pdb:7N8J|reactome:R-HSA-111932|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-442729|reactome:R-HSA-5693548|reactome:R-HSA-9018519|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|ensembl:ENSP00000504685|dip:DIP-6205N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DFtAbvPxkzWJO/fRLPGxA6pEEJQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05141	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17987	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13155	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745226|uniprotkb:Q75MR1|uniprotkb:Q96CZ5|uniprotkb:Q9P1L2|ensembl:ENSP00000223029|uniprotkb:F8W950	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:aimp2_human(display_long)|uniprotkb:Protein JTV-1(gene name synonym)|uniprotkb:AIMP2(gene name)|psi-mi:AIMP2(display_short)|uniprotkb:PRO0992(orf name)|uniprotkb:JTV1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006294.2|ensembl:ENSG00000106305(gene)|ensembl:ENST00000223029(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903632"(positive regulation of aminoacyl-tRNA ligase activity)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR031889|interpro:IPR036282|interpro:IPR041503|interpro:IPR042360|mint:Q13155|rcsb pdb:4DPG|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5Y6L|rcsb pdb:6ILD|rcsb pdb:6IY6|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-34421N|refseq:NP_001313536.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VEBmJjo6t3dBY6mKpmUyVLamJFQ9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62314	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372177|uniprotkb:P13641|uniprotkb:B5BTZ1|ensembl:ENSP00000300413	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd1_human(display_long)|uniprotkb:SNRPD1(gene name)|psi-mi:SNRPD1(display_short)|uniprotkb:snRNP core protein D1(gene name synonym)|uniprotkb:Sm-D autoantigen(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001278845.1|refseq:NP_008869.1|ensembl:ENSG00000167088(gene)|ensembl:ENST00000300413(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|go:"GO:0000243"(commitment complex)|interpro:IPR027141|interpro:IPR034102|mint:P62314|rcsb pdb:1B34|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|go:"GO:0000245"(spliceosomal complex assembly)|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5XJL|rcsb pdb:5XJQ|go:"GO:0000387"(spliceosomal snRNP assembly)|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|dip:DIP-31207N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfXwsV+IOjDPCoOJOoMQgECyiII9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H3K6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642537|uniprotkb:A1L454|uniprotkb:A7YDY3|ensembl:ENSP00000331127|ensembl:ENSP00000498355	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bola2_human(display_long)|uniprotkb:BOLA2(gene name)|psi-mi:BOLA2(display_short)|uniprotkb:BOLA2B(gene name)|psi-mi:BOLA2B(display_short)|uniprotkb:BOLA2A(gene name synonym)|uniprotkb:My016(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001026997.1|refseq:NP_001034271.1|refseq:NP_001307508.1|refseq:XP_016855107.1|ensembl:ENSG00000169627(gene)|ensembl:ENSG00000183336(gene)|ensembl:ENST00000330978(transcript)|ensembl:ENST00000651894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR002634(BolA-like protein)|interpro:IPR036065|mint:Q9H3K6|reactome:R-HSA-8950505	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5TcFdmQcwx5trexmXkWp9Arn5zE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y266	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43242	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08559	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33993	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96EP5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2133162|uniprotkb:Q96MJ3|uniprotkb:Q9NRR9|ensembl:ENSP00000233078	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dazp1_human(display_long)|uniprotkb:DAZAP1(gene name)|psi-mi:DAZAP1(display_short)|uniprotkb:Deleted in azoospermia-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061832.2|refseq:NP_733829.1|ensembl:ENSG00000071626(gene)|ensembl:ENST00000233078(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034046"("poly(G) binding")|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034131|interpro:IPR034134|interpro:IPR035979|mint:Q96EP5|rcsb pdb:2DGS|rcsb pdb:2DH8	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4uZCZTXZGnZAD9tBcurmc8RhGwY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49406	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1188518|uniprotkb:Q96Q52|uniprotkb:Q53TX9|ensembl:ENSP00000377486|ensembl:ENSP00000387284	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rm19_human(display_long)|uniprotkb:MRPL15(gene name synonym)|uniprotkb:39S ribosomal protein L15, mitochondrial(gene name synonym)|uniprotkb:MRPL19(gene name)|psi-mi:MRPL19(display_short)|uniprotkb:KIAA0104(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein bL19m(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055578.2|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7O9M|ensembl:ENSG00000115364(gene)|ensembl:ENST00000393909(transcript)|ensembl:ENST00000409374(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR001857(Ribosomal protein L19)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR038657|mint:P49406|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4ZCZpq3u9wkdpuNVFpk+bhceaW09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9GZT3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15233	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P41252	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355303|uniprotkb:Q5TCD0|uniprotkb:Q9H588|uniprotkb:A8KAE9|uniprotkb:Q7Z3T4|ensembl:ENSP00000364794|ensembl:ENSP00000406448|ensembl:ENSP00000507144	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syic_human(display_long)|uniprotkb:IARS1(gene name)|psi-mi:IARS1(display_short)|uniprotkb:IARS(gene name synonym)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002152.2|refseq:NP_038203.2|ensembl:ENSG00000196305(gene)|ensembl:ENST00000375643(transcript)|ensembl:ENST00000443024(transcript)|ensembl:ENST00000683565(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023586|interpro:IPR033709|mint:P41252|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:maAJX/O1Ryxr5NVFQEWvXNgHXyY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y295	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719554|uniprotkb:Q6FGP8|uniprotkb:Q8WW69|uniprotkb:Q9UGF2|uniprotkb:B2RDS8|ensembl:ENSP00000329715	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:drg1_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 3(gene name synonym)|uniprotkb:DRG1(gene name)|psi-mi:DRG1(display_short)|uniprotkb:NEDD3(gene name synonym)|uniprotkb:Translation factor GTPase DRG1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004138.1|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|rcsb pdb:2EKI|go:"GO:0005844"(polysome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007275"(multicellular organism development)|ensembl:ENSG00000185721(gene)|ensembl:ENST00000331457(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gVbgvaeulEwp7MdnP+qRgZ/aawA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BUL8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25705	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15181	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712298|ensembl:ENSP00000362329|uniprotkb:Q2M348|uniprotkb:Q5SQT7|uniprotkb:Q6P7P4|uniprotkb:Q9UQJ5|uniprotkb:Q9Y5B1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipyr_human(display_long)|uniprotkb:Pyrophosphate phospho-hydrolase(gene name synonym)|uniprotkb:PPA1(gene name)|psi-mi:PPA1(display_short)|uniprotkb:IOPPP(gene name synonym)|uniprotkb:PP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000180817(gene)|ensembl:ENST00000373232(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008162(Inorganic pyrophosphatase)|interpro:IPR036649|mint:Q15181|rcsb pdb:6C45|rcsb pdb:7BTN|rcsb pdb:7CMO|reactome:R-HSA-379716|reactome:R-HSA-71737|refseq:NP_066952.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1094gn9aeisgfDUhIroRn2iqom49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15145	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351829|uniprotkb:O00554|ensembl:ENSP00000228825	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arpc3_human(display_long)|uniprotkb:ARPC3(gene name)|psi-mi:ARPC3(display_short)|uniprotkb:ARC21(gene name synonym)|uniprotkb:Arp2/3 complex 21 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000111229(gene)|ensembl:ENST00000228825(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031941"(filamentous actin)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0061850"(growth cone leading edge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR007204(ARP2/3 complex, 21 kDa p21-Arc subunit)|interpro:IPR036753|mint:O15145|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|refseq:NP_001274151.1|refseq:NP_001265485.1|dip:DIP-33187N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u4h1270mPo3E3GBrEurYtpUYTQM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43684	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050987|uniprotkb:O43685|uniprotkb:B2R6E7|uniprotkb:A6NJ42|uniprotkb:D3DRE9|ensembl:ENSP00000357858	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bub3_human(display_long)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001007794.1|refseq:NP_004716.1|ensembl:ENSG00000154473(gene)|ensembl:ENST00000368865(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR020472|interpro:IPR036322|mint:O43684|reactome:R-HSA-141430|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|dip:DIP-24205N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nqzARPql2cThSUpxSb6PuTRn51E9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H3S7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724478|uniprotkb:Q7KZF8|uniprotkb:Q8N6Z5|uniprotkb:Q9BSR5|uniprotkb:Q9P257|uniprotkb:Q9UG03|uniprotkb:Q9UMZ4|uniprotkb:A8K0D7|ensembl:ENSP00000265562	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptn23_human(display_long)|uniprotkb:His domain-containing protein tyrosine phosphatase(gene name synonym)|uniprotkb:Protein tyrosine phosphatase TD14(gene name synonym)|uniprotkb:PTPN23(gene name)|psi-mi:PTPN23(display_short)|uniprotkb:KIAA1471(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056281.1|ensembl:ENSG00000076201(gene)|ensembl:ENST00000265562(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0060271"(cilium assembly)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903387"(positive regulation of homophilic cell adhesion)|go:"GO:1903393"(positive regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004328(BRO1)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR025304|interpro:IPR029021|interpro:IPR038499|mint:Q9H3S7|rcsb pdb:5CRU|rcsb pdb:5CRV|rcsb pdb:5LM1|rcsb pdb:5LM2|rcsb pdb:5MJY|rcsb pdb:5MJZ|rcsb pdb:5MK0|rcsb pdb:5MK1|rcsb pdb:5MK2|rcsb pdb:5MK3|reactome:R-HSA-9008059|rcsb pdb:3RAU|refseq:NP_001291411.1|dip:DIP-29923N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PeqzQLL4J4v9IMuHFBlb+1B4Ujw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61313	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-443462|ensembl:ENSP00000309334|ensembl:ENSP00000346867|ensembl:ENSP00000388529|ensembl:ENSP00000416692|ensembl:ENSP00000483260|ensembl:ENSP00000493759|uniprotkb:Q642I1|uniprotkb:Q9H2E5|uniprotkb:P39030|uniprotkb:P41051|uniprotkb:Q6IPX6|uniprotkb:Q8WYP2|uniprotkb:Q96C44|uniprotkb:Q5U0C0|intact:EBI-2877712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl15_human(display_long)|uniprotkb:RPL15(gene name)|psi-mi:RPL15(display_short)|uniprotkb:EC45(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL15(gene name synonym)|uniprotkb:TCBAP0781(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000174748(gene)|ensembl:ENST00000307839(transcript)|ensembl:ENST00000354811(transcript)|ensembl:ENST00000413699(transcript)|ensembl:ENST00000415719(transcript)|ensembl:ENST00000611050(transcript)|ensembl:ENST00000644185(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|interpro:IPR000439(Ribosomal protein L15e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR020925|interpro:IPR024794|mint:P61313|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_002939.2|refseq:NP_001240308.1|refseq:NP_001240309.1|refseq:NP_001240311.1|refseq:NP_001240312.1|refseq:NP_001240313.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wllGpJicgC5uwkZV6e4QRwDcrBo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00291	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51692	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08727	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742756|uniprotkb:Q5XG83|uniprotkb:Q6NW33|uniprotkb:Q7L5M9|uniprotkb:Q96A53|uniprotkb:Q96FV1|uniprotkb:Q9BYF9|uniprotkb:Q9P1Y4|uniprotkb:B2R874|ensembl:ENSP00000355124	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c19_human(display_long)|uniprotkb:Cytokeratin-19(gene name synonym)|uniprotkb:Keratin-19(gene name synonym)|uniprotkb:KRT19(gene name)|psi-mi:KRT19(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002267.2|ensembl:ENSG00000171345(gene)|ensembl:ENST00000361566(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990357"(terminal web)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P08727|reactome:R-HSA-6805567|reactome:R-HSA-6809371|dip:DIP-35655N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fqsG2nghpcmTtI39LiYVLNYuFIA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75179	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355530|uniprotkb:Q6PJ85|uniprotkb:Q6PK85|uniprotkb:Q6PKA2|uniprotkb:Q86XI3|uniprotkb:Q8NDR5|uniprotkb:Q96I86|uniprotkb:Q9H6J9|uniprotkb:Q9H288|ensembl:ENSP00000351416|uniprotkb:G5E964|uniprotkb:E7EUV3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anr17_human(display_long)|uniprotkb:ANKRD17(gene name)|psi-mi:ANKRD17(display_short)|uniprotkb:GTAR(gene name synonym)|uniprotkb:KIAA0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-16(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_115593.3|refseq:NP_942592.1|refseq:NP_056389.1|ensembl:ENSG00000132466(gene)|ensembl:ENST00000358602(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:O75179|go:"GO:0031965"(nuclear membrane)|refseq:NP_001273700.1|ensembl:ENST00000330838|ensembl:ENSP00000332265|ensembl:ENSP00000351416|ensembl:ENST00000509867|ensembl:ENSP00000427151|dip:DIP-47290N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l/gkMCasWF6pn6feuIzeQKWwwKM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22087	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358318|uniprotkb:O75259|uniprotkb:Q6IAT5|uniprotkb:Q9UPI6|ensembl:ENSP00000221801|ensembl:ENSP00000487390|uniprotkb:B5BUE8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fbrl_human(display_long)|uniprotkb:FBL(gene name)|psi-mi:FBL(display_short)|uniprotkb:FIB1(gene name synonym)|uniprotkb:FLRN(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)|uniprotkb:34 kDa nucleolar scleroderma antigen(gene name synonym)|uniprotkb:U6 snRNA 2'-O-methyltransferase fibrillarin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001427.2|ensembl:ENSG00000105202(gene)|ensembl:ENSG00000280548(gene)|ensembl:ENST00000221801(transcript)|ensembl:ENST00000625241(transcript)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0001652"(granular component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|mint:P22087|rcsb pdb:2IPX|reactome:R-HSA-6790901|reactome:R-HSA-6791226|dip:DIP-27569N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8m8FDRSxGNKNXpJMcWWbcHL3uss9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13838	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348622|uniprotkb:B0S8C0|uniprotkb:Q5STB8|uniprotkb:O43496|uniprotkb:Q0EFA1|uniprotkb:Q2L6F9|uniprotkb:Q53GL9|uniprotkb:Q5RJ64|uniprotkb:Q5RJ66|uniprotkb:Q5ST94|uniprotkb:Q5STB4|uniprotkb:Q5STB5|uniprotkb:Q5STB7|uniprotkb:Q5STU4|uniprotkb:Q5STU5|uniprotkb:Q5STU6|uniprotkb:Q5STU8|uniprotkb:Q71V76|ensembl:ENSP00000373000|ensembl:ENSP00000379475|ensembl:ENSP00000383151|ensembl:ENSP00000383152|ensembl:ENSP00000387994|ensembl:ENSP00000388880|ensembl:ENSP00000390999|ensembl:ENSP00000391463|ensembl:ENSP00000393712|ensembl:ENSP00000394160|ensembl:ENSP00000398775|ensembl:ENSP00000399030|ensembl:ENSP00000400326|ensembl:ENSP00000404695|ensembl:ENSP00000405560|ensembl:ENSP00000407419|ensembl:ENSP00000411136|ensembl:ENSP00000411853|ensembl:ENSP00000416269	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dx39b_human(display_long)|uniprotkb:UAP56(gene name synonym)|uniprotkb:DDX39B(gene name)|psi-mi:DDX39B(display_short)|uniprotkb:DEAD box protein UAP56(gene name synonym)|uniprotkb:56 kDa U2AF65-associated protein(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p47(gene name synonym)|uniprotkb:HLA-B-associated transcript 1 protein(gene name synonym)|uniprotkb:BAT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004631.1|refseq:NP_542165.1|ensembl:ENSG00000198563(gene)|ensembl:ENSG00000215425(gene)|ensembl:ENSG00000225073(gene)|ensembl:ENSG00000225859(gene)|ensembl:ENSG00000229496(gene)|ensembl:ENSG00000230624(gene)|ensembl:ENSG00000235439(gene)|ensembl:ENST00000383508(transcript)|ensembl:ENST00000396172(transcript)|ensembl:ENST00000400295(transcript)|ensembl:ENST00000400296(transcript)|ensembl:ENST00000412106(transcript)|ensembl:ENST00000412330(transcript)|ensembl:ENST00000413678(transcript)|ensembl:ENST00000414440(transcript)|ensembl:ENST00000415689(transcript)|ensembl:ENST00000416863(transcript)|ensembl:ENST00000430784(transcript)|ensembl:ENST00000431360(transcript)|ensembl:ENST00000441425(transcript)|ensembl:ENST00000445218(transcript)|ensembl:ENST00000448296(transcript)|ensembl:ENST00000453138(transcript)|ensembl:ENST00000456476(transcript)|ensembl:ENST00000456666(transcript)|ensembl:ENST00000458640(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000346"(transcription export complex)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0008380"(RNA splicing)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q13838|rcsb pdb:1T5I|rcsb pdb:1T6N|rcsb pdb:1XTI|rcsb pdb:1XTJ|rcsb pdb:1XTK|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9013418	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Cl/rf1oq31fZbLHC2foUXu9MBOE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15153	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489652|ensembl:ENSP00000249071|uniprotkb:Q9UDJ4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rac2_human(display_long)|uniprotkb:p21-Rac2(gene name synonym)|uniprotkb:Small G protein(gene name synonym)|uniprotkb:GX(gene name synonym)|uniprotkb:RAC2(gene name)|psi-mi:RAC2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045453"(bone resorption)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060753"(regulation of mast cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P15153|rcsb pdb:1DS6|rcsb pdb:2W2T|rcsb pdb:2W2V|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-1222556|go:"GO:0043304"(regulation of mast cell degranulation)|ensembl:ENSG00000128340(gene)|ensembl:ENST00000249071(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0005925"(focal adhesion)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|reactome:R-HSA-1257604|refseq:NP_002863.1|reactome:R-HSA-2219530|reactome:R-HSA-4086400|reactome:R-HSA-5668599|reactome:R-HSA-6811558|reactome:R-HSA-9013404|dip:DIP-34291N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NYkPt/WNmKM3qAhhaufLCPkc/io9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13247	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745230|uniprotkb:Q13244|uniprotkb:Q13245|uniprotkb:Q96J06|uniprotkb:Q9UJB8|uniprotkb:Q9Y3N7|uniprotkb:B7Z6J3|uniprotkb:E1P5W6|ensembl:ENSP00000244020	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf6_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP55(gene name synonym)|uniprotkb:SRSF6(gene name)|psi-mi:SRSF6(display_short)|uniprotkb:SRP55(gene name synonym)|uniprotkb:SFRS6(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006266.2|ensembl:ENSG00000124193(gene)|ensembl:ENST00000244020(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0032868"(response to insulin)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0045617"(negative regulation of keratinocyte differentiation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061041"(regulation of wound healing)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029541|interpro:IPR034511|interpro:IPR035979|mint:Q13247|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vU4nobP3g/hsgnll0mQgjJcME2k9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96HS1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BSD7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2689235|ensembl:ENSP00000355587	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ntpcr_human(display_long)|uniprotkb:Nucleoside triphosphate phosphohydrolase(gene name synonym)|uniprotkb:NTPCR(gene name)|psi-mi:NTPCR(display_short)|uniprotkb:C1orf57(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_115700.1|interpro:IPR027417|mint:Q9BSD7|rcsb pdb:2I3B|ensembl:ENSG00000135778(gene)|ensembl:ENST00000366628(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004948(Protein of unknown function DUF265)|refseq:NP_001316382.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tJoP+XQzoa4urq6g1rdZhMWO49g9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9HB71	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61221	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61158	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351428|uniprotkb:P32391|ensembl:ENSP00000263238|uniprotkb:Q53QM2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arp3_human(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005712.1|ensembl:ENSG00000115091(gene)|ensembl:ENST00000263238(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:P61158|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33140N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15357	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3D9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054270|uniprotkb:Q96Q24|uniprotkb:Q9BWH8|uniprotkb:Q9P053|uniprotkb:B2R6V3|ensembl:ENSP00000320184	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rt23_human(display_long)|uniprotkb:MRPS23(gene name)|psi-mi:MRPS23(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS23(gene name synonym)|uniprotkb:CGI-138(orf name)|uniprotkb:HSPC329(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057154.2|ensembl:ENSG00000181610(gene)|ensembl:ENST00000313608(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0031965"(nuclear membrane)|interpro:IPR019520|interpro:IPR023611|mint:Q9Y3D9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6Iyu6KkT1Y0+n0LKWy5Gf0DkhHw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26641	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62913	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354380|uniprotkb:P25121|uniprotkb:P39026|uniprotkb:Q8TDH2|uniprotkb:Q9Y674|ensembl:ENSP00000496250	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl11_human(display_long)|uniprotkb:RPL11(gene name)|psi-mi:RPL11(display_short)|uniprotkb:CLL-associated antigen KW-12(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000966.2|refseq:NP_001186731.1|ensembl:ENSG00000142676(gene)|ensembl:ENST00000643754(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006605"(protein targeting)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR002132(Ribosomal protein L5)|interpro:IPR020929|interpro:IPR022803|interpro:IPR031309|interpro:IPR031310|mint:P62913|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4XXB|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y6X	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xt8XhDkfQPoH4DIPr0gC+ll766Q9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P68371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351356|uniprotkb:P05217|uniprotkb:A2BFA2|ensembl:ENSP00000341289	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb4b_human(display_long)|uniprotkb:TUBB4B(gene name)|psi-mi:TUBB4B(display_short)|uniprotkb:TUBB2C(gene name synonym)|uniprotkb:Tubulin beta-2 chain(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006079.1|ensembl:ENSG00000188229(gene)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|go:"GO:0005200"(structural constituent of cytoskeleton)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68371|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|ensembl:ENST00000340384(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4LwMs7E7eILMjB9Z/1bstAp22CY9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15029	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A6NHR9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2801919|uniprotkb:O75141|uniprotkb:Q6AHX6|uniprotkb:Q9H6Q2|uniprotkb:Q6ZTQ8|intact:EBI-3192385|uniprotkb:Q9UG39|ensembl:ENSP00000326603	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smhd1_human(display_long)|uniprotkb:KIAA0650(gene name synonym)|uniprotkb:SMCHD1(gene name)|psi-mi:SMCHD1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056110.2|ensembl:ENSG00000101596(gene)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR036277|interpro:IPR036890|interpro:IPR038892|mint:A6NHR9|rcsb pdb:6MW7|ensembl:ENST00000320876(transcript)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006302"(double-strand break repair)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043584"(nose development)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0060820"(inactivation of X chromosome by heterochromatin assembly)|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7tHwsz7p8pAqG9grnerpgMTmt3Q9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49368	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00232	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N1F7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042703|uniprotkb:Q14705|uniprotkb:B3KPQ8|ensembl:ENSP00000310668	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nup93_human(display_long)|uniprotkb:NUP93(gene name)|psi-mi:NUP93(display_short)|uniprotkb:KIAA0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055484.3|refseq:NP_001229724.1|refseq:NP_001229725.1|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8N1F7|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|ensembl:ENSG00000102900(gene)|reactome:R-HSA-168271|ensembl:ENST00000308159(transcript)|go:"GO:0005635"(nuclear envelope)|reactome:R-HSA-168276|go:"GO:0005643"(nuclear pore)|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-191859|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005256320.1|dip:DIP-44020N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pkk5pooUC4yQShpqjiwNLddfy149606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08779	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356410|uniprotkb:P30654|uniprotkb:Q16402|uniprotkb:Q9UBG8|uniprotkb:A8K488|ensembl:ENSP00000301653	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c16_human(display_long)|uniprotkb:KRT16(gene name)|psi-mi:KRT16(display_short)|uniprotkb:KRT16A(gene name synonym)|uniprotkb:Keratin-16(gene name synonym)|uniprotkb:Cytokeratin-16(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005548.2|ensembl:ENSG00000186832(gene)|ensembl:ENST00000301653(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007568"(aging)|go:"GO:0030216"(keratinocyte differentiation)|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031424"(keratinization)|go:"GO:0042633"(hair cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051546"(keratinocyte migration)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P08779	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NkPTLkWquNNlGYbrXaRkyRmKvmM9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33992	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y230	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13283	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00571	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26196	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61160	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353580|ensembl:ENSP00000260641|uniprotkb:O15142|uniprotkb:Q96C82|uniprotkb:B2RCP5|uniprotkb:D6W5F4|uniprotkb:E9PF41	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arp2_human(display_long)|uniprotkb:ACTR2(gene name)|psi-mi:ACTR2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:Actin-like protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000138071(gene)|ensembl:ENST00000260641(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008306"(associative learning)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0016482"(cytosolic transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0030478"(actin cap)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035861"(site of double-strand break)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:NP_001005386.1|refseq:NP_005713.1|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|mint:P61160|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33165N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:URQsZpIsMtsFZAnpLYDDvgKcPqA9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q07955	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14839-1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5279755|ensembl:ENSP00000440542	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q14839-1(display_long)|uniprotkb:CHD4(gene name)|psi-mi:CHD4(display_short)|uniprotkb:ATP-dependent helicase CHD4(gene name synonym)|uniprotkb:Mi-2 autoantigen 218 kDa protein(gene name synonym)|uniprotkb:Mi2-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	intact:EBI-372916(isoform-parent)|ensembl:ENSG00000111642(gene)|ensembl:ENST00000544040(transcript)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:E9eHT/41SIFRiz54J81hvPQeHIE9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P56385	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2270000|uniprotkb:Q0D2L9|ensembl:ENSP00000306003	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atp5i_human(display_long)|uniprotkb:ATP5ME(gene name)|psi-mi:ATP5ME(display_short)|uniprotkb:ATP5I(gene name synonym)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:ATP5K(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009031.1|ensembl:ENSG00000169020(gene)|ensembl:ENST00000304312(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P56385|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NYpqzWQYASXwSwU/BYDTMU2tJjI9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NZI8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053892|uniprotkb:C9JT33|ensembl:ENSP00000290341	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2b1_human(display_long)|uniprotkb:ZBP1(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 1(gene name synonym)|uniprotkb:Coding region determinant-binding protein(gene name synonym)|uniprotkb:VICKZ family member 1(gene name synonym)|uniprotkb:IGF2BP1(gene name)|psi-mi:IGF2BP1(display_short)|uniprotkb:Zipcode-binding protein 1(gene name synonym)|uniprotkb:CRDBP(gene name synonym)|uniprotkb:VICKZ1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006537.3|refseq:NP_001153895.1|ensembl:ENSG00000159217(gene)|ensembl:ENST00000290341(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010610"(regulation of mRNA stability involved in response to stress)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022013"(pallium cell proliferation in forebrain)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140059"(dendrite arborization)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034837|interpro:IPR034842|interpro:IPR035979|interpro:IPR036612|mint:Q9NZI8|rcsb pdb:3KRM|rcsb pdb:6QEY|reactome:R-HSA-428359|reactome:R-HSA-5687128|dip:DIP-38139N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Ps/PWWYr0WpYcx3G/AOiQEj+vc9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8TC07	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048247|uniprotkb:B9A6L6|intact:EBI-6190229|uniprotkb:B4DMT9|uniprotkb:J3KNI9|uniprotkb:Q9HA83|intact:EBI-28984447|ensembl:ENSP00000448182	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbc15_human(display_long)|uniprotkb:TBC1D15(gene name)|psi-mi:TBC1D15(display_short)|uniprotkb:GTPase-activating protein RAB7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001139685.2|refseq:NP_001139686.1|refseq:NP_073608.4|ensembl:ENST00000319106|ensembl:ENSP00000318262|ensembl:ENST00000485960|ensembl:ENSP00000420678|ensembl:ENSP00000448182|ensembl:ENSG00000121749(gene)|ensembl:ENST00000550746(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3tlqjLtZ/Bq5H6M00sHIwqNqqw49606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99832	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00459	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15785	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054499|uniprotkb:Q53GH9|uniprotkb:Q6IBN7|uniprotkb:Q9NTZ3|ensembl:ENSP00000361900	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tom34_human(display_long)|uniprotkb:URCC3(gene name synonym)|uniprotkb:Translocase of outer membrane 34 kDa subunit(gene name synonym)|uniprotkb:TOMM34(gene name)|psi-mi:TOMM34(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006800.2|ensembl:ENSG00000025772(gene)|ensembl:ENST00000372813(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:K0J5GQoRwg/7Yz0p2e41R1wQrME9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P29692	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358607|uniprotkb:Q969J1|uniprotkb:D3DWK3|intact:EBI-748782|uniprotkb:Q96I38|ensembl:ENSP00000317399|ensembl:ENSP00000378551|ensembl:ENSP00000388261|ensembl:ENSP00000433412|ensembl:ENSP00000433611|ensembl:ENSP00000434448|ensembl:ENSP00000434872|ensembl:ENSP00000436542|ensembl:ENSP00000436933|ensembl:ENSP00000478340|ensembl:ENSP00000479653|ensembl:ENSP00000483527|ensembl:ENSP00000487680|intact:EBI-11048966|uniprotkb:Q4VBZ6|uniprotkb:B4DDU4|uniprotkb:E9PBQ9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1d_human(display_long)|uniprotkb:EEF1D(gene name)|psi-mi:EEF1D(display_short)|uniprotkb:EF1D(gene name synonym)|uniprotkb:Antigen NY-CO-4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001123528.1|refseq:NP_001123527.1|refseq:NP_001123529.1|refseq:NP_001951.2|refseq:XP_011515207.1|refseq:XP_011515208.1|ensembl:ENST00000419152(transcript)|ensembl:ENST00000529272(transcript)|ensembl:ENST00000530191(transcript)|ensembl:ENST00000530445(transcript)|ensembl:ENST00000531218(transcript)|ensembl:ENST00000533494(transcript)|ensembl:ENST00000534380(transcript)|ensembl:ENST00000614575(transcript)|ensembl:ENST00000615067(transcript)|ensembl:ENST00000615698(transcript)|ensembl:ENST00000632587(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010941"(regulation of cell death)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045296"(cadherin binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219|mint:P29692|rcsb pdb:2MVM|rcsb pdb:2MVN|rcsb pdb:2N51|rcsb pdb:5JPO|reactome:R-HSA-156842|ensembl:ENSG00000104529(gene)|ensembl:ENSG00000273594(gene)|ensembl:ENST00000317198(transcript)|ensembl:ENST00000395119(transcript)|refseq:NP_001304672.1|refseq:NP_001182132.1|refseq:NP_001276879.1|refseq:XP_006716585.1|refseq:XP_006716586.1|refseq:XP_006716587.1|refseq:XP_006716588.1|refseq:XP_005250880.1|refseq:NP_001317575.1|refseq:XP_016868659.1|refseq:NP_001123525.2|refseq:NP_115754.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9Mzpfofeg2W/GQ/JfjFxcCFJnKg9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P01857	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PAU2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189929|ensembl:ENSP00000482486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pau2_human(display_long)|uniprotkb:RAVER1(gene name)|psi-mi:RAVER1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000611074(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034633|interpro:IPR034635|interpro:IPR035979|ensembl:ENSG00000161847(gene)|refseq:NP_597709.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:R49B14TFxiQLK5QlLBcHyZQTKD09606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15559	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191076|imex:IM-17358-6|pride:19288|pride:19299|pmc:19301|pride:19297|pride:19298|pride:19289|pride:19300	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	intact-crc:B7BD9008D767AEAE|rigid:cpwWRCfNXnoVj9WFjY7osuPOC7M	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6P2Q9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I0ot8b3pvieXRI66omFm145sGVA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18754	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-992720|uniprotkb:Q16269|uniprotkb:Q6NT97|ensembl:ENSP00000362939|ensembl:ENSP00000381931|ensembl:ENSP00000508074|ensembl:ENSP00000362938	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rcc1_human(display_long)|uniprotkb:Chromosome condensation protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein(gene name synonym)|uniprotkb:RCC1(gene name)|psi-mi:RCC1(display_short)|uniprotkb:CHC1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001041659.1|refseq:NP_001041660.1|refseq:NP_001041664.1|refseq:NP_001260.1|dip:DIP-35416N|ensembl:ENSG00000180198(gene)|ensembl:ENST00000373832(transcript)|ensembl:ENST00000373833(transcript)|ensembl:ENST00000398958(transcript)|ensembl:ENST00000683442(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003682"(chromatin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016032"(viral process)|rcsb pdb:5E1B|rcsb pdb:5E1D|rcsb pdb:5E1M|rcsb pdb:5E1O|rcsb pdb:5E2A|go:"GO:0031267"(small GTPase binding)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031492"(nucleosomal DNA binding)|rcsb pdb:5E2B|rcsb pdb:5TBK|rcsb pdb:6DUB|reactome:R-HSA-165054|go:"GO:0031965"(nuclear membrane)|reactome:R-HSA-180746|reactome:R-HSA-9615933|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:P18754|rcsb pdb:1A12|rcsb pdb:1I2M	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/gP2xQp6fUffHTXpXvs8eb5YJ209606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52594	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50914	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356746|uniprotkb:Q45RF0|uniprotkb:Q53G20|uniprotkb:Q8TBD5|uniprotkb:Q8WUT0|uniprotkb:Q92579|uniprotkb:Q96GR0|uniprotkb:Q9BSB8|uniprotkb:Q9BW65|uniprotkb:Q9BYF6|ensembl:ENSP00000345156|ensembl:ENSP00000379506	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl14_human(display_long)|uniprotkb:RPL14(gene name)|psi-mi:RPL14(display_short)|uniprotkb:CAG-ISL 7(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL14(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001030168.1|refseq:NP_003964.3|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002784(Ribosomal protein L14)|interpro:IPR008991(Translation protein SH3-like)|ensembl:ENSG00000188846(gene)|ensembl:ENST00000338970(transcript)|ensembl:ENST00000396203(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041985|mint:P50914|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|interpro:IPR039660|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y2L	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AjaguD5hgHtcBbJq5QfuG6XdTcE9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55884	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13492	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2803688|uniprotkb:Q86XZ9|uniprotkb:O60700|uniprotkb:Q6GMQ6|intact:EBI-28967113|ensembl:ENSP00000377015|uniprotkb:B4DTM3|uniprotkb:E9PN05|uniprotkb:F8VPG7|uniprotkb:Q4LE54	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pical_human(display_long)|uniprotkb:CALM(gene name synonym)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:PICALM(gene name)|psi-mi:PICALM(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000356360|ensembl:ENSP00000348718|ensembl:ENSP00000377015|ensembl:ENST00000526033|ensembl:ENSP00000433846|ensembl:ENST00000528398|ensembl:ENSP00000434884|ensembl:ENST00000532317|ensembl:ENSP00000436958|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0005634"(nucleus)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR030412|mint:Q13492|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9696264|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0032050"(clathrin heavy chain binding)|ensembl:ENSG00000073921(gene)|ensembl:ENST00000393346(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:0055072"(iron ion homeostasis)|refseq:NP_001008660.1|refseq:NP_001193875.1|refseq:NP_001193876.1|refseq:NP_009097.2|refseq:XP_005274388.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UIZhYyYqmBCyN4xwPCl9PeCdK8Q9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5JXB2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190823|uniprotkb:E9KL27	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ue2nl_human(display_long)|uniprotkb:Epididymis tissue protein Li 174(gene name synonym)|uniprotkb:UBE2NL(gene name)|psi-mi:UBE2NL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0000209"(protein polyubiquitination)|refseq:NP_001013007.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sh3UsocorMe1c+Y1g5ZEhvrblEk9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61313	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-443462|ensembl:ENSP00000309334|ensembl:ENSP00000346867|ensembl:ENSP00000388529|ensembl:ENSP00000416692|ensembl:ENSP00000483260|ensembl:ENSP00000493759|uniprotkb:Q642I1|uniprotkb:Q9H2E5|uniprotkb:P39030|uniprotkb:P41051|uniprotkb:Q6IPX6|uniprotkb:Q8WYP2|uniprotkb:Q96C44|uniprotkb:Q5U0C0|intact:EBI-2877712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl15_human(display_long)|uniprotkb:RPL15(gene name)|psi-mi:RPL15(display_short)|uniprotkb:EC45(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL15(gene name synonym)|uniprotkb:TCBAP0781(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000174748(gene)|ensembl:ENST00000307839(transcript)|ensembl:ENST00000354811(transcript)|ensembl:ENST00000413699(transcript)|ensembl:ENST00000415719(transcript)|ensembl:ENST00000611050(transcript)|ensembl:ENST00000644185(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|interpro:IPR000439(Ribosomal protein L15e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR020925|interpro:IPR024794|mint:P61313|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_002939.2|refseq:NP_001240308.1|refseq:NP_001240309.1|refseq:NP_001240311.1|refseq:NP_001240312.1|refseq:NP_001240313.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wllGpJicgC5uwkZV6e4QRwDcrBo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07355	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NZM3-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190150|ensembl:ENSP00000354561	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q9nzm3-2(display_long)|uniprotkb:ITSN2(gene name)|psi-mi:ITSN2(display_short)|uniprotkb:KIAA1256(gene name synonym)|uniprotkb:SH3D1B(gene name synonym)|uniprotkb:SWAP(gene name synonym)|uniprotkb:SH3 domain-containing protein 1B(gene name synonym)|uniprotkb:SH3P18(gene name synonym)|uniprotkb:SH3P18-like WASP-associated protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198399(gene)|ensembl:ENST00000361999(transcript)|intact:EBI-308689(isoform-parent)|uniprotkb:Q9NZM3-2(isoform-parent)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WTz75JabFgL3LVJ2FJZk81RTmfY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46779	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366357|uniprotkb:Q6IAY0|uniprotkb:Q96FX1|uniprotkb:Q9BWQ0|uniprotkb:B2R4A6|uniprotkb:B4DEP9|uniprotkb:E9PB24|uniprotkb:C9JB50|uniprotkb:G5E9L2|ensembl:ENSP00000342787|ensembl:ENSP00000453319	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl28_human(display_long)|uniprotkb:RPL28(gene name)|psi-mi:RPL28(display_short)|uniprotkb:Large ribosomal subunit protein eL28(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129608.1|refseq:NP_001129609.1|refseq:NP_000982.2|refseq:NP_001129606.1|refseq:NP_001129607.1|ensembl:ENSG00000108107(gene)|ensembl:ENST00000344063(transcript)|ensembl:ENST00000559463(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002672(Ribosomal protein L28e)|interpro:IPR029004|mint:P46779|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I7Me1zjfxk98g6C2NoYOWlmrYVc9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09661	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876439|uniprotkb:Q8TBD2|uniprotkb:B2R5I6|ensembl:ENSP00000254193	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ru2a_human(display_long)|uniprotkb:SNRPA1(gene name)|psi-mi:SNRPA1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003081.2|dip:DIP-625N|ensembl:ENSG00000131876(gene)|ensembl:ENST00000254193(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR044640|mint:P09661|rcsb pdb:1A9N|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|reactome:R-HSA-8950505	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tmZyAPCvMg34GY4kVc6NcnycOeE9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9ULH0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716681|uniprotkb:A1L4N4|intact:EBI-2798329|uniprotkb:Q6MZU2|uniprotkb:Q9H889|uniprotkb:Q9H9E4|uniprotkb:Q9NT37|uniprotkb:Q9UF42|uniprotkb:Q4VC08|ensembl:ENSP00000256707	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kdis_human(display_long)|uniprotkb:KIAA1250(gene name synonym)|uniprotkb:KIDINS220(gene name)|psi-mi:KIDINS220(display_short)|uniprotkb:ARMS(gene name synonym)|uniprotkb:Ankyrin repeat-rich membrane-spanning protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065789.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000134313(gene)|ensembl:ENST00000256707(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR002110(Ankyrin)|interpro:IPR011646(KAP P-loop)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9ULH0|reactome:R-HSA-170984|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0wyaXuvXCqQTlfjuW4TAcIGmdlw9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62917	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-438527|ensembl:ENSP00000262584|ensembl:ENSP00000378378|ensembl:ENSP00000433464|uniprotkb:P25120|uniprotkb:Q567Q7|uniprotkb:Q969V7|uniprotkb:Q9BWQ9|uniprotkb:A8K094|uniprotkb:D3DWN2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl8_human(display_long)|uniprotkb:RPL8(gene name)|psi-mi:RPL8(display_short)|uniprotkb:Large ribosomal subunit protein uL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4CCN|rcsb pdb:4CCO|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4Y3O|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000161016(gene)|ensembl:ENST00000262584(transcript)|ensembl:ENST00000394920(transcript)|ensembl:ENST00000528957(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0098794"(postsynapse)|interpro:IPR002171(Ribosomal protein L2)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR014726(Ribosomal protein L2, domain 3)|interpro:IPR022666|interpro:IPR022669|interpro:IPR022671|interpro:IPR023672|mint:P62917|rcsb pdb:4CCM|refseq:NP_000964.1|refseq:NP_150644.1|refseq:NP_001304700.1|refseq:NP_001304711.1|dip:DIP-37967N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+b/ORzdCy/nqFLsKRV9VhIZgdjg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P99999	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H0A0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26358	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43242	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UKM9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714796|uniprotkb:Q14621|uniprotkb:Q2M365|uniprotkb:Q5QPL8|uniprotkb:Q9BQX6|uniprotkb:Q9UJE3|ensembl:ENSP00000246194	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:raly_human(display_long)|uniprotkb:hnRNP associated with lethal yellow protein homolog(gene name synonym)|uniprotkb:Autoantigen p542(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein C-like 2(gene name synonym)|uniprotkb:RALY(gene name)|psi-mi:RALY(display_short)|uniprotkb:P542(gene name synonym)|uniprotkb:HNRPCL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011526996.1|refseq:XP_011526997.1|ensembl:ENSG00000125970(gene)|ensembl:ENST00000246194(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR034502|interpro:IPR035979|mint:Q9UKM9|rcsb pdb:1WF1|refseq:NP_031393.2|refseq:NP_057951.1|refseq:XP_005260391.1|refseq:XP_005260393.1|refseq:XP_016883220.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3hd0n2UW0FSRNvSJa2mqflVeorc9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-395393|uniprotkb:P08918|uniprotkb:P08919|uniprotkb:Q14860|uniprotkb:Q16295|ensembl:ENSP00000266732	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lap2a_human(display_long)|uniprotkb:TMPO(gene name)|psi-mi:TMPO(display_short)|uniprotkb:LAP2(gene name synonym)|uniprotkb:Thymopoietin isoform alpha(gene name synonym)|uniprotkb:Thymopoietin-related peptide isoform alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003267.1|ensembl:ENSG00000120802(gene)|ensembl:ENST00000266732(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0045296"(cadherin binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR013146(Thymopoietin LEM)|interpro:IPR021623|mint:P42166|rcsb pdb:1GJJ|rcsb pdb:1H9E|rcsb pdb:1H9F	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/kq+6sQN9B8jf+Ee4uPj7gtWe509606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13242	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2949710|ensembl:ENSP00000229390|uniprotkb:Q52LD1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf9_human(display_long)|uniprotkb:SRSF9(gene name)|psi-mi:SRSF9(display_short)|uniprotkb:SFRS9(gene name synonym)|uniprotkb:SRP30C(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30C(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006397"(mRNA processing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0006376"(mRNA splice site selection)|interpro:IPR034503|interpro:IPR034995|interpro:IPR035979|mint:Q13242|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|ensembl:ENSG00000111786(gene)|ensembl:ENST00000229390(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_003760.1|dip:DIP-40741N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9x6TWFk1zN1YodjXBiwi/MtNJe49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047080|uniprotkb:Q15074|intact:EBI-1171814|uniprotkb:Q6IMN4|uniprotkb:A6NMY7|uniprotkb:Q6IMN7|uniprotkb:Q9BV09|intact:EBI-2562858|intact:EBI-3449178|uniprotkb:D3DR06|ensembl:ENSP00000340329|ensembl:ENSP00000434150	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:capr1_human(display_long)|uniprotkb:CAPRIN1(gene name)|psi-mi:CAPRIN1(display_short)|uniprotkb:GPIAP1(gene name synonym)|uniprotkb:GPIP137(gene name synonym)|uniprotkb:M11S1(gene name synonym)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Cell cycle-associated protein 1(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:RNG105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005889.3|refseq:NP_976240.1|ensembl:ENSG00000135387(gene)|ensembl:ENST00000341394(transcript)|ensembl:ENST00000532820(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q14444|rcsb pdb:4WBE|rcsb pdb:4WBP|rcsb pdb:6TA7|refseq:XP_016873238.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3c6ZdBClP/D6jIi8NfzBkMc61pI9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43324	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048486|uniprotkb:Q5THS2|ensembl:ENSP00000369038|uniprotkb:C9JLK5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mca3_human(display_long)|uniprotkb:Multisynthase complex auxiliary component p18(gene name synonym)|uniprotkb:Elongation factor p18(gene name synonym)|uniprotkb:EEF1E1(gene name)|psi-mi:EEF1E1(display_short)|uniprotkb:P18(gene name synonym)|uniprotkb:AIMP3(gene name synonym)|uniprotkb:Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129122.1|refseq:NP_004271.1|ensembl:ENSG00000124802(gene)|ensembl:ENST00000379715(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036282|interpro:IPR042450|mint:O43324|rcsb pdb:2UZ8|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5BMU|rcsb pdb:5Y6L|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-50581N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4AuJouC9q6uAH/4EH8SKSPHyEZU9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02543	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350523|ensembl:ENSP00000222247	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl18a_human(display_long)|uniprotkb:RPL18A(gene name)|psi-mi:RPL18A(display_short)|uniprotkb:Large ribosomal subunit protein eL20(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000971.1|interpro:IPR021138|interpro:IPR023573|interpro:IPR028877|mint:Q02543|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|go:"GO:0097327"(response to antineoplastic agent)|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|ensembl:ENSG00000105640(gene)|ensembl:ENST00000222247(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|rcsb pdb:6ZME|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O9XdW7Let2GcJpJLVuUtatVVv1I9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7KZF4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044112|uniprotkb:Q13122|ensembl:ENSP00000346762|uniprotkb:Q96AG0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snd1_human(display_long)|uniprotkb:100 kDa coactivator(gene name synonym)|uniprotkb:EBNA2 coactivator p100(gene name synonym)|uniprotkb:Tudor domain-containing protein 11(gene name synonym)|uniprotkb:SND1(gene name)|psi-mi:SND1(display_short)|uniprotkb:p100 co-activator(gene name synonym)|uniprotkb:TDRD11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055205.2|ensembl:ENSG00000197157(gene)|ensembl:ENST00000354725(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0042470"(melanosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097433"(dense body)|go:"GO:1905172"(RISC complex binding)|interpro:IPR002071(Thermonuclease active site)|interpro:IPR002999(Tudor)|interpro:IPR016071("Staphylococcal nuclease (SNase-like), OB-fold")|interpro:IPR016685(RNA-induced silencing complex, nuclease component Tudor-SN)|interpro:IPR035437|mint:Q7KZF4|rcsb pdb:2E6N|rcsb pdb:2HQE|rcsb pdb:2HQX|rcsb pdb:2O4X|rcsb pdb:3BDL|rcsb pdb:3OMC|rcsb pdb:3OMG|rcsb pdb:4QMG|rcsb pdb:5M9O|reactome:R-HSA-6802952|dip:DIP-29613N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I9JNlRfASs5dwk0JZQ+F+GsW94g9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38919	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299104|ensembl:ENSP00000497641|ensembl:ENSP00000497661|uniprotkb:Q15033|uniprotkb:Q96A18|uniprotkb:Q6IBQ2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4a3_human(display_long)|uniprotkb:KIAA0111(gene name synonym)|uniprotkb:EIF4A3(gene name)|psi-mi:EIF4A3(display_short)|uniprotkb:DDX48(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4A isoform 3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DDX48(gene name synonym)|uniprotkb:DEAD box protein 48(gene name synonym)|uniprotkb:Eukaryotic initiation factor 4A-like NUK-34(gene name synonym)|uniprotkb:Nuclear matrix protein 265(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072715"(cellular response to selenite ion)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904570"(negative regulation of selenocysteine incorporation)|go:"GO:1904574"(negative regulation of selenocysteine insertion sequence binding)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P38919|rcsb pdb:2HXY|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:4C9B|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6YVH|rcsb pdb:7A5P|reactome:R-HSA-1169408|reactome:R-HSA-159236|reactome:R-HSA-429947|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|ensembl:ENST00000647795(transcript)|ensembl:ENST00000649764(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|ensembl:ENSG00000141543(gene)|refseq:NP_055555.1|dip:DIP-33218N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8e6e4HlM1GsYqqgXyJ9XgzxLzls9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6I3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713198|intact:EBI-28967658|ensembl:ENSP00000270460|uniprotkb:Q86ST3|uniprotkb:Q9HA18	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:epn1_human(display_long)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:EH domain-binding mitotic phosphoprotein(gene name synonym)|uniprotkb:EPN1(gene name)|psi-mi:EPN1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048568"(embryonic organ development)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q9Y6I3|rcsb pdb:1INZ|rcsb pdb:1KYD|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000063245(gene)|ensembl:ENST00000270460(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|ensembl:ENST00000085079|ensembl:ENSP00000085079|ensembl:ENSP00000270460|ensembl:ENST00000411543|ensembl:ENSP00000406209|refseq:NP_001123543.1|refseq:NP_001123544.1|refseq:NP_037465.2|refseq:XP_005258886.1|refseq:XP_016882211.1|refseq:XP_011525183.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mp6MIJYGUJryy3Lk5coFqvOt55c9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14618	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y230	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00541	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053271|uniprotkb:Q6IC29|ensembl:ENSP00000346725	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pesc_human(display_long)|uniprotkb:PES1(gene name)|psi-mi:PES1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001230154.1|refseq:NP_055118.1|ensembl:ENSG00000100029(gene)|ensembl:ENST00000354694(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000466"("maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|interpro:IPR001357(BRCT)|interpro:IPR010613(Pescadillo, N-terminal)|interpro:IPR036420|rcsb pdb:2EP8|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Nq1SJ37kJfe+vF9zmNASz1gnbfY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350581|uniprotkb:B2R4B3|ensembl:ENSP00000346015	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl27a_human(display_long)|uniprotkb:RPL27A(gene name)|psi-mi:RPL27A(display_short)|uniprotkb:Large ribosomal subunit protein uL15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000981.1|ensembl:ENSG00000166441(gene)|ensembl:ENST00000314138(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001196(Ribosomal protein L15)|interpro:IPR021131|interpro:IPR027386|interpro:IPR030878|interpro:IPR036227|mint:P46776|rcsb pdb:4BXF|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6IP6|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6OM7|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:6IP5|dip:DIP-33121N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tUezMQBw+SWmLYq8M0pkLCF8vO89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5J1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-592816|uniprotkb:Q9H4N6|ensembl:ENSP00000225298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:utp18_human(display_long)|uniprotkb:WD repeat-containing protein 50(gene name synonym)|uniprotkb:UTP18(gene name)|psi-mi:UTP18(display_short)|uniprotkb:CGI-48(orf name)|uniprotkb:CDABP0061(orf name)|uniprotkb:WDR50(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057085.2|ensembl:ENSG00000011260(gene)|ensembl:ENST00000225298(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q9Y5J1|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l873IUyfCql4N9VelHPuUEqpzRY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43707	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351526|uniprotkb:O76048|uniprotkb:D6PXK4|ensembl:ENSP00000252699|ensembl:ENSP00000489220|uniprotkb:A4K467	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:actn4_human(display_long)|uniprotkb:ACTN4(gene name)|psi-mi:ACTN4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004915.2|ensembl:ENSG00000130402(gene)|ensembl:ENSG00000282844(gene)|ensembl:ENST00000252699(transcript)|ensembl:ENST00000634960(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:O43707|rcsb pdb:1WLX|rcsb pdb:1YDI|rcsb pdb:2R0O|rcsb pdb:6O31|rcsb pdb:6OA6|reactome:R-HSA-114608|reactome:R-HSA-373753|dip:DIP-33179N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kTYezA2lEtL/AQPfCQ8BE79nzow9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5A9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2878081|uniprotkb:B4E1G7|uniprotkb:A6NKG4|uniprotkb:Q5VSZ9|uniprotkb:Q8TDH0|uniprotkb:Q9BUJ5|uniprotkb:A8K966|uniprotkb:D3DPM8|ensembl:ENSP00000362918|ensembl:ENSP00000444660	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ythd2_human(display_long)|uniprotkb:HGRG8(gene name synonym)|uniprotkb:CLL-associated antigen KW-14(gene name synonym)|uniprotkb:High-glucose-regulated protein 8(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-2(gene name synonym)|uniprotkb:YTHDF2(gene name)|psi-mi:YTHDF2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001166299.1|refseq:NP_001166599.1|refseq:NP_057342.2|ensembl:ENSG00000198492(gene)|ensembl:ENST00000373812(transcript)|ensembl:ENST00000542507(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045087"(innate immune response)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070925"(organelle assembly)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:2000232"(regulation of rRNA processing)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR007275(YT521-B-like protein)|mint:Q9Y5A9|rcsb pdb:4RDO|rcsb pdb:4WQN|rcsb pdb:4RDN	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PF4C2t/728HqnrTyBQDJydH0G709606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61160	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353580|ensembl:ENSP00000260641|uniprotkb:O15142|uniprotkb:Q96C82|uniprotkb:B2RCP5|uniprotkb:D6W5F4|uniprotkb:E9PF41	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arp2_human(display_long)|uniprotkb:ACTR2(gene name)|psi-mi:ACTR2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:Actin-like protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000138071(gene)|ensembl:ENST00000260641(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008306"(associative learning)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0016482"(cytosolic transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0030478"(actin cap)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035861"(site of double-strand break)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:NP_001005386.1|refseq:NP_005713.1|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|mint:P61160|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33165N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:URQsZpIsMtsFZAnpLYDDvgKcPqA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43175	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5SRE5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049404|uniprotkb:Q14675|uniprotkb:Q2TA87|uniprotkb:Q7Z3K8|uniprotkb:Q8IWF1|intact:EBI-2555229|ensembl:ENSP00000361658	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu188_human(display_long)|uniprotkb:NUP188(gene name)|psi-mi:NUP188(display_short)|uniprotkb:KIAA0169(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056169.1|ensembl:ENSG00000095319(gene)|ensembl:ENST00000372577(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018864|interpro:IPR044840|mint:Q5SRE5|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eoj+tg9RAVKcVlT9ku1ozXCa3u89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y490	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55769	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712228|ensembl:ENSP00000215956|ensembl:ENSP00000383949|ensembl:ENSP00000497142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nh2l1_human(display_long)|uniprotkb:SNU13(gene name)|psi-mi:SNU13(display_short)|uniprotkb:High mobility group-like nuclear protein 2 homolog 1(gene name synonym)|uniprotkb:NHP2L1(gene name synonym)|uniprotkb:OTK27(gene name synonym)|uniprotkb:SNU13 homolog(gene name synonym)|uniprotkb:U4/U6.U5 small nuclear ribonucleoprotein SNU13(gene name synonym)|uniprotkb:U4/U6.U5 tri-snRNP 15.5 kDa protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100138(gene)|ensembl:ENST00000215956(transcript)|ensembl:ENST00000401959(transcript)|ensembl:ENST00000648674(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0007338"(single fertilization)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051117"(ATPase binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P55769|rcsb pdb:1E7K|rcsb pdb:2JNB|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_001003796.1|refseq:NP_004999.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZMkqsDfMCrTlT/kJxillOA8839E9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6B6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4290665|uniprotkb:D3DQA4|uniprotkb:Q567T4|ensembl:ENSP00000385432|ensembl:ENSP00000404997	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sar1b_human(display_long)|uniprotkb:SAR1B(gene name)|psi-mi:SAR1B(display_short)|uniprotkb:SARA2(gene name synonym)|uniprotkb:SARB(gene name synonym)|uniprotkb:GTP-binding protein B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000152700(gene)|ensembl:ENST00000402673(transcript)|ensembl:ENST00000439578(transcript)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0061024"(membrane organization)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006687(GTP-binding protein SAR1)|interpro:IPR006689(ARF/SAR superfamily)|go:"GO:0003400"(regulation of COPII vesicle coating)|interpro:IPR027417|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-5694530|reactome:R-HSA-8963888|reactome:R-HSA-983170|reactome:R-HSA-1655829|refseq:NP_001028675.1|refseq:NP_057187.1|refseq:XP_016865010.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Tq+D9CeccMteZSbthpVFFBuazjY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54886	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1210304|ensembl:ENSP00000360268|uniprotkb:O95952|uniprotkb:Q5T566|uniprotkb:Q9UM72|uniprotkb:Q3KQU2|uniprotkb:B2R5Q4|uniprotkb:B7Z350|uniprotkb:B7Z5X8|uniprotkb:B7ZLP1|uniprotkb:Q5T567|uniprotkb:D3DR44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p5cs_human(display_long)|uniprotkb:ALDH18A1(gene name)|psi-mi:ALDH18A1(display_short)|uniprotkb:P5CS(gene name synonym)|uniprotkb:PYCS(gene name synonym)|uniprotkb:GSAS(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 18 member A1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000059573(gene)|ensembl:ENST00000371224(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004349"(glutamate 5-kinase activity)|go:"GO:0004350"(glutamate-5-semialdehyde dehydrogenase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0006592"(ornithine biosynthetic process)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000965(Gamma-glutamyl phosphate reductase GPR)|interpro:IPR001048(Aspartate/glutamate/uridylate kinase)|refseq:NP_001017423.1|refseq:NP_002851.2|refseq:NP_001310341.1|refseq:NP_001310342.1|refseq:NP_001310343.1|refseq:NP_001310344.1|refseq:NP_001310345.1|refseq:NP_001310348.1|interpro:IPR001057(Glutamate 5-kinase)|interpro:IPR005715(Glutamate 5-kinase, ProB-related)|interpro:IPR005766(delta l-pyrroline-5-carboxylate synthetase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR019797|interpro:IPR020593|interpro:IPR036393|interpro:IPR041744|mint:P54886|rcsb pdb:2H5G|reactome:R-HSA-8964539	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NLYlqQhi3HebSXYBxkkSmKplRCM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P20700	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-968218|ensembl:ENSP00000261366|uniprotkb:Q3SYN7|uniprotkb:Q96EI6|uniprotkb:B2R6J6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lmnb1_human(display_long)|uniprotkb:LMNB1(gene name)|psi-mi:LMNB1(display_short)|uniprotkb:LMN2(gene name synonym)|uniprotkb:LMNB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000113368(gene)|ensembl:ENST00000261366(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P20700|rcsb pdb:2KPW|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3JT0|rcsb pdb:3TYY|rcsb pdb:3UMN|rcsb pdb:5VVX|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|reactome:R-HSA-2559584|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-4419969|reactome:R-HSA-8862803|reactome:R-HSA-8950505|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:NP_005564.1|dip:DIP-34897N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZLv4OS5VSmn3sdXB9IP98YdQ+Iw9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9GZT3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99613	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N684	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746909|uniprotkb:C9K0Q4|uniprotkb:Q7Z3H9|uniprotkb:Q9H025|uniprotkb:Q9H9V1|uniprotkb:B3KU04|ensembl:ENSP00000378352	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpsf7_human(display_long)|uniprotkb:Cleavage and polyadenylation specificity factor 59 kDa subunit(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 59 kDa subunit(gene name synonym)|uniprotkb:CPSF7(gene name)|psi-mi:CPSF7(display_short)|uniprotkb:Cleavage factor Im complex 59 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129512.1|refseq:NP_001136037.1|refseq:NP_079087.3|refseq:XP_011543560.1|refseq:XP_011543561.1|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0016020"(membrane)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034770|interpro:IPR034772|interpro:IPR034773|interpro:IPR035979|mint:Q8N684|rcsb pdb:3N9U|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|ensembl:ENSG00000149532(gene)|ensembl:ENST00000394888(transcript)|refseq:XP_005274356.1|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfliZhw27GRZMSQpYRZ/x/tWGh49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22234	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712261|ensembl:ENSP00000264221|ensembl:ENSP00000421096|uniprotkb:E9PDH9|uniprotkb:Q68CQ5|intact:EBI-21352784	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pur6_human(display_long)|uniprotkb:PAICS(gene name)|psi-mi:PAICS(display_short)|uniprotkb:ADE2(gene name synonym)|uniprotkb:AIRC(gene name synonym)|uniprotkb:PAIS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000128050(gene)|ensembl:ENST00000264221(transcript)|ensembl:ENST00000512576(transcript)|go:"GO:0004639"(phosphoribosylaminoimidazolesuccinocarboxamide synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043727"(5-amino-4-imidazole carboxylate lyase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000031("1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase")|interpro:IPR018236|interpro:IPR028923|interpro:IPR033626|mint:P22234|rcsb pdb:2H31|rcsb pdb:6YB8|go:"GO:0004638"(phosphoribosylaminoimidazole carboxylase activity)|rcsb pdb:6YB9|reactome:R-HSA-73817|refseq:NP_001072992.1|refseq:NP_001072993.1|refseq:NP_006443.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aR4Xj14ZQrPiY8cldw5o9AvjkAo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09429	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-389432|uniprotkb:Q6IBE1|uniprotkb:A5D8W9|uniprotkb:Q14321|uniprotkb:Q5T7C3|ensembl:ENSP00000343040|ensembl:ENSP00000345347|ensembl:ENSP00000382417|ensembl:ENSP00000384678	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmgb1_human(display_long)|uniprotkb:HMGB1(gene name)|psi-mi:HMGB1(display_short)|uniprotkb:HMG1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002119.1|refseq:NP_001300821.1|refseq:NP_001300822.1|ensembl:ENSG00000189403(gene)|ensembl:ENST00000339872(transcript)|ensembl:ENST00000341423(transcript)|ensembl:ENST00000399494(transcript)|ensembl:ENST00000405805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006265"(DNA topological change)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|interpro:IPR036910|mint:P09429|rcsb pdb:2LY4|rcsb pdb:2RTU|rcsb pdb:2YRQ|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|reactome:R-HSA-1236974|reactome:R-HSA-140342|reactome:R-HSA-166058|reactome:R-HSA-445989|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|dip:DIP-24195N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8iSPxYEMyB6thRmixTeyF5kfDbw9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25788	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348380|ensembl:ENSP00000216455|uniprotkb:Q86U83|uniprotkb:Q8N1D8|uniprotkb:Q9BS70|uniprotkb:B2RCK6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa3_human(display_long)|uniprotkb:PSMA3(gene name)|psi-mi:PSMA3(display_short)|uniprotkb:PSC8(gene name synonym)|uniprotkb:Proteasome component C8(gene name synonym)|uniprotkb:Macropain subunit C8(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C8(gene name synonym)|uniprotkb:HC8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002779.1|refseq:NP_687033.1|ensembl:ENSG00000100567(gene)|ensembl:ENST00000216455(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR037555|mint:P25788|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:5DSV|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|rcsb pdb:7E55|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:5T0H|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-174084|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-174113|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|dip:DIP-29366N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9Er/PY50/GVoCr5yAPXlkfxtP0k9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42285	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347612|uniprotkb:Q2M386|uniprotkb:Q6MZZ8|uniprotkb:Q6P170|uniprotkb:Q8N5R0|uniprotkb:Q8TAG2|ensembl:ENSP00000230640	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mtrex_human(display_long)|uniprotkb:MTREX(gene name)|psi-mi:MTREX(display_short)|uniprotkb:DOB1(gene name synonym)|uniprotkb:KIAA0052(gene name synonym)|uniprotkb:MTR4(gene name synonym)|uniprotkb:SKIV2L2(gene name synonym)|uniprotkb:Superkiller viralicidic activity 2-like 2(gene name synonym)|uniprotkb:TRAMP-like complex helicase(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DOB1(gene name synonym)|uniprotkb:ATP-dependent RNA helicase SKIV2L2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056175.3|ensembl:ENSG00000039123(gene)|ensembl:ENST00000230640(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016076"(snRNA catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0031499"(TRAMP complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|mint:P42285|rcsb pdb:6C90|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6IEG|rcsb pdb:6IEH|rcsb pdb:6RO1|reactome:R-HSA-6791226|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bQdFDddFhetSp+CJ1S7Q5cm+g0k9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62241	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351811|uniprotkb:Q6IRL7|uniprotkb:P09058|ensembl:ENSP00000379888	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs8_human(display_long)|uniprotkb:RPS8(gene name)|psi-mi:RPS8(display_short)|uniprotkb:Small ribosomal subunit protein eS8(gene name synonym)|uniprotkb:OK/SW-cl.83(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001003.1|ensembl:ENSG00000142937(gene)|ensembl:ENST00000396651(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001047(Ribosomal protein S8e)|interpro:IPR018283|interpro:IPR022309|interpro:IPR042563|mint:P62241|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:6G5H|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975957|reactome:R-HSA-975956	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3rpCBdQyRWR+TCKnupbnCp30jKE9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62899	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053664|intact:EBI-3867511|uniprotkb:B7Z4K2|uniprotkb:P12947|uniprotkb:Q53SQ5|uniprotkb:Q6LBJ6|uniprotkb:D3DVJ4|uniprotkb:Q6IRZ0|ensembl:ENSP00000264258|ensembl:ENSP00000386681	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl31_human(display_long)|uniprotkb:RPL31(gene name)|psi-mi:RPL31(display_short)|uniprotkb:Large ribosomal subunit protein eL31(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000984.1|refseq:NP_001092047.1|refseq:NP_001093163.1|ensembl:ENSG00000071082(gene)|ensembl:ENST00000264258(transcript)|ensembl:ENST00000409733(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|mint:P62899|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:77LFR7/2somk6blVogZf1XFdJLk9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49588	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709710|uniprotkb:A6NF14|uniprotkb:Q53GV7|uniprotkb:Q96FA0|uniprotkb:B4DR45|ensembl:ENSP00000261772|ensembl:ENSP00000501924|ensembl:ENSP00000502247|ensembl:ENSP00000502797	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syac_human(display_long)|uniprotkb:AARS1(gene name)|psi-mi:AARS1(display_short)|uniprotkb:AARS(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-42(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001596.2|ensembl:ENSG00000090861(gene)|ensembl:ENST00000261772(transcript)|ensembl:ENST00000674691(transcript)|ensembl:ENST00000674963(transcript)|ensembl:ENST00000675643(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016597"(amino acid binding)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140018"(regulation of cytoplasmic translational fidelity)|interpro:IPR002318(Alanyl-tRNA synthetase, class IIc)|interpro:IPR003156(Phosphoesterase, DHHA1)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018162|interpro:IPR018163|interpro:IPR018164|interpro:IPR018165|interpro:IPR023033|mint:P49588|rcsb pdb:4XEM|rcsb pdb:4XEO|rcsb pdb:5KNN|rcsb pdb:5T5S|rcsb pdb:5T76|rcsb pdb:5V59|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e9+gLroLXvK8li0wiPBGbZhQqP49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42566	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-396684|uniprotkb:B2R8J7|uniprotkb:Q5SRH4|uniprotkb:D3DPJ2|intact:EBI-28966731|ensembl:ENSP00000360798	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eps15_human(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153441.1|refseq:NP_001972.1|ensembl:ENSP00000360798|ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P42566|rcsb pdb:1C07|rcsb pdb:1EH2|rcsb pdb:1F8H|rcsb pdb:1FF1|rcsb pdb:2IV9|rcsb pdb:2JXC|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4S0G|rcsb pdb:5AWT|rcsb pdb:5AWU|rcsb pdb:5JP2|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|dip:DIP-33064N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P37108	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353399|uniprotkb:Q6B0K5|intact:EBI-1053250|uniprotkb:Q96Q14|uniprotkb:B5BUF5|ensembl:ENSP00000267884	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srp14_human(display_long)|uniprotkb:SRP14(gene name)|psi-mi:SRP14(display_short)|uniprotkb:18 kDa Alu RNA-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003125.3|dip:DIP-6152N|ensembl:ENSG00000140319(gene)|ensembl:ENST00000267884(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045047"(protein targeting to ER)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003210(Signal recognition particle, SRP14 subunit)|interpro:IPR009018(Signal recognition particle, SRP9/SRP14 subunit)|mint:P37108|rcsb pdb:1E8O|rcsb pdb:1E8S|rcsb pdb:1RY1|rcsb pdb:4UYJ|rcsb pdb:4UYK|rcsb pdb:5AOX|rcsb pdb:7NFX|reactome:R-HSA-1799339|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0xHelIgJbXaUrFsHGoj1wDQKdPs9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BUF5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7L2E3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1211456|uniprotkb:O94965|uniprotkb:Q7Z753|uniprotkb:Q96CH4|uniprotkb:Q9NUQ0|uniprotkb:A8K5F1|ensembl:ENSP00000392601|ensembl:ENSP00000405620|intact:EBI-21350949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx30_human(display_long)|uniprotkb:DHX30(gene name)|psi-mi:DHX30(display_short)|uniprotkb:KIAA0890(gene name synonym)|uniprotkb:DDX30(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055781.2|refseq:NP_619520.1|refseq:XP_011531796.1|refseq:XP_011531797.1|refseq:XP_016861406.1|ensembl:ENSG00000132153(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007417"(central nervous system development)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q7L2E3|rcsb pdb:2DB2|ensembl:ENST00000445061(transcript)|ensembl:ENST00000446256(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tb4GzZKLycraXS0NlVqj8reV3IQ9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43487	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1032909|uniprotkb:Q53EY3|ensembl:ENSP00000327583	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rang_human(display_long)|uniprotkb:RANBP1(gene name)|psi-mi:RANBP1(display_short)|uniprotkb:Ran-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002873.1|ensembl:ENSG00000099901(gene)|ensembl:ENST00000331821(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0046907"(intracellular transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1K5D|rcsb pdb:1K5G|reactome:R-HSA-165054|refseq:NP_001265568.1|refseq:NP_001265569.1|dip:DIP-35058N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OWndphaUCDSO3+MGhJqcuQo2Lk09606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15233	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8TC07	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048247|uniprotkb:B9A6L6|intact:EBI-6190229|uniprotkb:B4DMT9|uniprotkb:J3KNI9|uniprotkb:Q9HA83|intact:EBI-28984447|ensembl:ENSP00000448182	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbc15_human(display_long)|uniprotkb:TBC1D15(gene name)|psi-mi:TBC1D15(display_short)|uniprotkb:GTPase-activating protein RAB7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001139685.2|refseq:NP_001139686.1|refseq:NP_073608.4|ensembl:ENST00000319106|ensembl:ENSP00000318262|ensembl:ENST00000485960|ensembl:ENSP00000420678|ensembl:ENSP00000448182|ensembl:ENSG00000121749(gene)|ensembl:ENST00000550746(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3tlqjLtZ/Bq5H6M00sHIwqNqqw49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08752	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9ULV4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351384|uniprotkb:Q9NSK5|uniprotkb:B3KU12|ensembl:ENSP00000261401|ensembl:ENSP00000438341|intact:EBI-4404698|uniprotkb:A7MAP0|uniprotkb:A7MAP1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cor1c_human(display_long)|uniprotkb:CORO1C(gene name)|psi-mi:CORO1C(display_short)|uniprotkb:CRNN4(gene name synonym)|uniprotkb:Coronin-3(gene name synonym)|uniprotkb:hCRNN4(gene name synonym)|uniprotkb:CRN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001263400.1|refseq:NP_055140.1|ensembl:ENSG00000110880(gene)|ensembl:ENST00000261401(transcript)|ensembl:ENST00000541050(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0090148"(membrane fission)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0016197"(endosomal transport)|go:"GO:0097750"(endosome membrane tubulation)|go:"GO:0140285"(endosome fission)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027333|interpro:IPR036322|mint:Q9ULV4|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|refseq:NP_001098707.1|refseq:XP_016874610.1|refseq:XP_016874611.1|refseq:XP_016874612.1|dip:DIP-33138N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Em/LQxjBk9n4tobk5ksyDfFSyeU9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75694	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050769|uniprotkb:Q9UBE9|uniprotkb:Q9UFL5|intact:EBI-28983292|ensembl:ENSP00000231498	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu155_human(display_long)|uniprotkb:Nucleoporin Nup155(gene name synonym)|uniprotkb:155 kDa nucleoporin(gene name synonym)|uniprotkb:KIAA0791(gene name synonym)|uniprotkb:NUP155(gene name)|psi-mi:NUP155(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004289.1|refseq:NP_705618.1|ensembl:ENSP00000231498|ensembl:ENST00000381843|ensembl:ENSP00000371265|ensembl:ENSG00000113569(gene)|ensembl:ENST00000231498(transcript)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036228"(protein localization to nuclear inner membrane)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|interpro:IPR004870(Nucleoporin, non-repetitive/WGA-negative)|interpro:IPR007187(Nucleoporin, Nup133-like, C-terminal)|interpro:IPR014908(Nup133, N-terminal)|interpro:IPR042533|interpro:IPR042537|interpro:IPR042538|rcsb pdb:5A9Q|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k6LjWvJdqtT78G4Wu12rJX/2WHo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13224	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2833037|uniprotkb:Q8NG40|uniprotkb:Q14422|ensembl:ENSP00000383382	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gp1bb_human(display_long)|uniprotkb:GP1BB(gene name)|psi-mi:GP1BB(display_short)|uniprotkb:Antigen CD42b-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000398.1|ensembl:ENSG00000203618(gene)|ensembl:ENST00000366425(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0042802"(identical protein binding)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR032675|mint:P13224|rcsb pdb:3REZ|rcsb pdb:3RFE|reactome:R-HSA-140837|reactome:R-HSA-430116|reactome:R-HSA-75892|reactome:R-HSA-76009|reactome:R-HSA-9673221	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eD4E+gbGDmXWJhX5W8jNjLLy0d89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14980	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05783	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297888|uniprotkb:Q53G38|uniprotkb:Q5U0N8|uniprotkb:Q9BW26|ensembl:ENSP00000373487|ensembl:ENSP00000373489	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c18_human(display_long)|uniprotkb:KRT18(gene name)|psi-mi:KRT18(display_short)|uniprotkb:CYK18(gene name synonym)|uniprotkb:Keratin-18(gene name synonym)|uniprotkb:PIG46(orf name)|uniprotkb:Cytokeratin-18(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 46 protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007049"(cell cycle)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009750"(response to fructose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0072497"(mesenchymal stem cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1902488"(cholangiocyte apoptotic process)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR027695|interpro:IPR039008|mint:P05783|reactome:R-HSA-6805567|reactome:R-HSA-6809371|ensembl:ENSG00000111057(gene)|ensembl:ENST00000388835(transcript)|ensembl:ENST00000388837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|refseq:NP_000215.1|refseq:NP_954657.1|dip:DIP-633N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6rtLZxuG0CSGcsCHEmkRKFVDeyo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36873	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356283|ensembl:ENSP00000335084	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1g_human(display_long)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0004721"(phosphoprotein phosphatase activity)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000335007(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0043197"(dendritic spine)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P36873|rcsb pdb:1IT6|rcsb pdb:1JK7|rcsb pdb:1U32|rcsb pdb:2BCD|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|rcsb pdb:2BDX|rcsb pdb:4UT2|rcsb pdb:4UT3|go:"GO:0046872"(metal ion binding)|rcsb pdb:5INB|go:"GO:0047485"(protein N-terminus binding)|rcsb pdb:5J28|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|reactome:R-HSA-141444|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-9648025|reactome:R-HSA-9660537|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-400253|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-68877|refseq:NP_001231903.1|refseq:NP_002701.1|dip:DIP-749N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SyjV/4d9V8lV/BXub2KESPKvupA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28482	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-959949|ensembl:ENSP00000215832|ensembl:ENSP00000381803|uniprotkb:A8CZ64	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mk01_human(display_long)|uniprotkb:MAPK1(gene name)|psi-mi:MAPK1(display_short)|uniprotkb:ERK2(gene name synonym)|uniprotkb:PRKM1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)|uniprotkb:PRKM2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-112411|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-437239|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|refseq:NP_002736.3|refseq:NP_620407.1|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P28482|rcsb pdb:1PME|go:"GO:0072686"(mitotic spindle)|rcsb pdb:1TVO|rcsb pdb:1WZY|rcsb pdb:2OJG|rcsb pdb:2OJI|rcsb pdb:2OJJ|rcsb pdb:2Y9Q|rcsb pdb:3D42|rcsb pdb:3D44|rcsb pdb:3I5Z|rcsb pdb:3I60|rcsb pdb:3SA0|rcsb pdb:3TEI|rcsb pdb:3W55|rcsb pdb:4FMQ|rcsb pdb:4FUX|rcsb pdb:4FUY|rcsb pdb:4FV0|rcsb pdb:4FV1|rcsb pdb:4FV2|rcsb pdb:4FV3|rcsb pdb:4FV4|rcsb pdb:4FV5|rcsb pdb:4FV6|rcsb pdb:4FV7|rcsb pdb:4FV8|rcsb pdb:4FV9|rcsb pdb:4G6N|rcsb pdb:4G6O|rcsb pdb:4H3P|rcsb pdb:4H3Q|rcsb pdb:4IZ5|rcsb pdb:4IZ7|rcsb pdb:4IZA|rcsb pdb:4N0S|rcsb pdb:4NIF|rcsb pdb:4O6E|rcsb pdb:4QP1|rcsb pdb:4QP2|rcsb pdb:4QP3|rcsb pdb:4QP4|rcsb pdb:4QP6|rcsb pdb:4QP7|rcsb pdb:4QP8|rcsb pdb:4QP9|rcsb pdb:4QPA|rcsb pdb:4QTA|rcsb pdb:4QTE|rcsb pdb:4XJ0|rcsb pdb:4ZXT|rcsb pdb:4ZZM|rcsb pdb:4ZZN|rcsb pdb:4ZZO|rcsb pdb:5AX3|rcsb pdb:5BUE|rcsb pdb:5BUI|rcsb pdb:5BUJ|rcsb pdb:5BVD|rcsb pdb:5BVE|rcsb pdb:5BVF|rcsb pdb:5K4I|rcsb pdb:5LCJ|rcsb pdb:5LCK|rcsb pdb:5NGU|rcsb pdb:5NHF|rcsb pdb:5NHH|rcsb pdb:5NHJ|rcsb pdb:5NHL|rcsb pdb:5NHO|rcsb pdb:5NHP|rcsb pdb:5NHV|rcsb pdb:5V60|rcsb pdb:5V61|rcsb pdb:5V62|rcsb pdb:5WP1|rcsb pdb:6D5Y|rcsb pdb:6DMG|rcsb pdb:6G54|rcsb pdb:6G8X|rcsb pdb:6G91|rcsb pdb:6G92|rcsb pdb:6G93|rcsb pdb:6G97|rcsb pdb:6G9A|rcsb pdb:6G9D|rcsb pdb:6G9H|rcsb pdb:6G9J|rcsb pdb:6G9K|rcsb pdb:6G9M|rcsb pdb:6G9N|rcsb pdb:6GDM|rcsb pdb:6GDQ|rcsb pdb:6GE0|rcsb pdb:6GJB|rcsb pdb:6GJD|rcsb pdb:6NBS|rcsb pdb:6OPG|rcsb pdb:6OPH|rcsb pdb:6OPI|rcsb pdb:6Q7K|rcsb pdb:6Q7S|rcsb pdb:6Q7T|rcsb pdb:6QA1|rcsb pdb:6QA3|rcsb pdb:6QA4|rcsb pdb:6QAG|rcsb pdb:6QAH|rcsb pdb:6QAL|rcsb pdb:6QAQ|rcsb pdb:6QAW|rcsb pdb:6RQ4|rcsb pdb:6SLG|reactome:R-HSA-111995|reactome:R-HSA-112409|ensembl:ENSG00000100030(gene)|ensembl:ENST00000215832(transcript)|ensembl:ENST00000398822(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634635|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9652817|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|dip:DIP-519N|ensembl:ENSP00000215832|ensembl:ENSP00000381803|ensembl:ENST00000544786|ensembl:ENSP00000440842	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:odzhd70I/8uWedx0+gF38lhe60I9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96HS1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95036	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190520	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:o95036_human(display_long)|uniprotkb:"WUGSC:H_RG054D04.1"(gene name)|psi-mi:"WUGSC:H_RG054D04.1"(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR018038|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/Wx1NRwTL4OL8HlPLKeaZ568pCA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P16401	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5327611|uniprotkb:Q14529|uniprotkb:Q3MJ42|ensembl:ENSP00000330074	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h15_human(display_long)|uniprotkb:H1-5(gene name)|psi-mi:H1-5(display_short)|uniprotkb:H1F5(gene name synonym)|uniprotkb:HIST1H1B(gene name synonym)|uniprotkb:Histone H1a(gene name synonym)|uniprotkb:Histone H1b(gene name synonym)|uniprotkb:Histone H1s-3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005313.1|ensembl:ENSG00000184357(gene)|ensembl:ENST00000331442(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0071169"(establishment of protein localization to chromatin)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2FE2|rcsb pdb:2RHI|reactome:R-HSA-140342|reactome:R-HSA-2559584|go:"GO:0000792"(heterochromatin)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:b81Z7VA09Na0XXDfR0HtaZmq1g89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UNQ2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-395738|uniprotkb:O76025|uniprotkb:Q9BU77|uniprotkb:Q9UES1|ensembl:ENSP00000199320	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dim1_human(display_long)|uniprotkb:DIMT1L(gene name synonym)|uniprotkb:DIM1 dimethyladenosine transferase 1 homolog(gene name synonym)|uniprotkb:DIM1 dimethyladenosine transferase 1-like(gene name synonym)|uniprotkb:HUSSY-05(orf name)|uniprotkb:"Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase"(gene name synonym)|uniprotkb:Probable 18S rRNA dimethylase(gene name synonym)|uniprotkb:DIMT1(gene name)|psi-mi:DIMT1(display_short)|uniprotkb:"Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055288.1|ensembl:ENSG00000086189(gene)|ensembl:ENST00000199320(transcript)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0031167"(rRNA methylation)|go:"GO:0052909"("18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity")|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR029063|mint:Q9UNQ2|rcsb pdb:1ZQ9|rcsb pdb:6W6C|rcsb pdb:6W6F|reactome:R-HSA-6790901|refseq:NP_001335005.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hx0FRrx+XTeoziOqfesiw4KL+wo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3B4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1046261|ensembl:ENSP00000233468|uniprotkb:Q53TM1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf3b6_human(display_long)|uniprotkb:SF3B6(gene name)|psi-mi:SF3B6(display_short)|uniprotkb:Pre-mRNA branch site protein p14(gene name synonym)|uniprotkb:SAP14(gene name synonym)|uniprotkb:SF3B14(gene name synonym)|uniprotkb:SF3B14A(gene name synonym)|uniprotkb:SF3b 14 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein, 14-kDa(gene name synonym)|uniprotkb:Splicing factor 3b, subunit 6, 14kDa(gene name synonym)|uniprotkb:CGI-110(orf name)|uniprotkb:HSPC175(orf name)|uniprotkb:HT006(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000233468(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000115128(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034150|interpro:IPR035979|mint:Q9Y3B4|rcsb pdb:2F9D|rcsb pdb:2F9J|rcsb pdb:2FHO|rcsb pdb:3LQV|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_057131.1|dip:DIP-44132N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7mhaXkmVqjfJGPdX1UDM+kN4vNI9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P59998	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351872|uniprotkb:O15509|uniprotkb:C9JWM7|uniprotkb:E7ETI0|uniprotkb:Q6P0W5|uniprotkb:Q96QJ3|ensembl:ENSP00000380431|uniprotkb:F6TTL5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arpc4_human(display_long)|uniprotkb:ARPC4(gene name)|psi-mi:ARPC4(display_short)|uniprotkb:ARC20(gene name synonym)|uniprotkb:Arp2/3 complex 20 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001185709.1|refseq:NP_005709.1|ensembl:ENSG00000241553(gene)|ensembl:ENST00000397261(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045010"(actin nucleation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008384(ARP23 complex 20 kDa subunit)|interpro:IPR034666|mint:P59998|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|refseq:NP_001020130.1|refseq:NP_001020131.1|dip:DIP-33188N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Iqe60TWfO3QBVOY+fOqZd9JWfIE9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40429	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-720205|uniprotkb:A8K505|ensembl:ENSP00000375730	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl13a_human(display_long)|uniprotkb:23 kDa highly basic protein(gene name synonym)|uniprotkb:RPL13A(gene name)|psi-mi:RPL13A(display_short)|uniprotkb:Large ribosomal subunit protein uL13(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036555.1|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|rcsb pdb:6OLF|ensembl:ENSG00000142541(gene)|ensembl:ENST00000391857(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1901194"(negative regulation of formation of translation preinitiation complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005755(Ribosomal protein L13, eukaryotic/archaeal)|interpro:IPR005822(Ribosomal protein L13)|interpro:IPR023563|interpro:IPR036899|mint:P40429|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|refseq:NP_001257420.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pcKDTEBZXxtm1MAH+4nv0p3PqFs9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39023	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056348|uniprotkb:Q15548|uniprotkb:Q5I0G0|uniprotkb:B2RDV9|ensembl:ENSP00000346001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl3_human(display_long)|uniprotkb:RPL3(gene name)|psi-mi:RPL3(display_short)|uniprotkb:HIV-1 TAR RNA-binding protein B(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL3(gene name synonym)|uniprotkb:OK/SW-cl.32(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000958.1|ensembl:ENSG00000100316(gene)|ensembl:ENST00000216146(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P39023|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:j3MVAYfO/bziJBPmH4zCFqFskZ89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54577	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048893|uniprotkb:O43276|uniprotkb:Q53EN1|uniprotkb:B3KWK4|uniprotkb:D3DPQ4|ensembl:ENSP00000362576	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syyc_human(display_long)|uniprotkb:YARS1(gene name)|psi-mi:YARS1(display_short)|uniprotkb:Tyrosyl-tRNA synthetase(gene name synonym)|uniprotkb:YARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003671.1|ensembl:ENSG00000134684(gene)|ensembl:ENST00000373477(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004831"(tyrosine-tRNA ligase activity)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006437"(tyrosyl-tRNA aminoacylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0016604"(nuclear body)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002307(Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial)|interpro:IPR002547(tRNA-binding region)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1N3L|rcsb pdb:1NTG|rcsb pdb:1Q11|rcsb pdb:4Q93|rcsb pdb:4QBT|rcsb pdb:5THH|rcsb pdb:5THL|reactome:R-HSA-379716|dip:DIP-50415N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y/0Qs8iOgW5w5LVLWnCvowVpEu89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A6NHR9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2801919|uniprotkb:O75141|uniprotkb:Q6AHX6|uniprotkb:Q9H6Q2|uniprotkb:Q6ZTQ8|intact:EBI-3192385|uniprotkb:Q9UG39|ensembl:ENSP00000326603	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smhd1_human(display_long)|uniprotkb:KIAA0650(gene name synonym)|uniprotkb:SMCHD1(gene name)|psi-mi:SMCHD1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056110.2|ensembl:ENSG00000101596(gene)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR036277|interpro:IPR036890|interpro:IPR038892|mint:A6NHR9|rcsb pdb:6MW7|ensembl:ENST00000320876(transcript)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006302"(double-strand break repair)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043584"(nose development)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0060820"(inactivation of X chromosome by heterochromatin assembly)|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7tHwsz7p8pAqG9grnerpgMTmt3Q9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99873	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06733	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13612	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5T4S7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1995940|intact:EBI-1059327|uniprotkb:A8MPT2|uniprotkb:A8MQ33|uniprotkb:A8MQB1|uniprotkb:O60646|uniprotkb:O75050|uniprotkb:Q4QRK5|uniprotkb:Q5T4S8|uniprotkb:Q5T4S9|uniprotkb:Q5TBN8|uniprotkb:Q5TBP2|uniprotkb:Q6DKH8|uniprotkb:Q6P4A4|uniprotkb:Q7L8P7|uniprotkb:Q8IXJ4|uniprotkb:Q8TDN5|uniprotkb:Q8WV67|uniprotkb:Q9HA46|uniprotkb:Q9P2N9|uniprotkb:Q9UG82|ensembl:ENSP00000364403	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubr4_human(display_long)|uniprotkb:UBR4(gene name)|psi-mi:UBR4(display_short)|uniprotkb:KIAA0462(gene name synonym)|uniprotkb:KIAA1307(gene name synonym)|uniprotkb:RBAF600(gene name synonym)|uniprotkb:ZUBR1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:Retinoblastoma-associated factor of 600 kDa(gene name synonym)|uniprotkb:600 kDa retinoblastoma protein-associated factor(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065816.2|ensembl:ENST00000375218|ensembl:ENSP00000364403|ensembl:ENSP00000364366|ensembl:ENSG00000127481(gene)|ensembl:ENST00000375254(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:Q5T4S7|reactome:R-HSA-6798695|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Iown8oj965YAir+95+3om5+1YM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92614	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-949059|ensembl:ENSP00000437073|uniprotkb:Q5H9U3|uniprotkb:Q5W9F9|uniprotkb:Q5W9G1|uniprotkb:Q8IXP8|uniprotkb:Q5QD01	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:my18a_human(display_long)|uniprotkb:Myosin containing a PDZ domain(gene name synonym)|uniprotkb:Molecule associated with JAK3 N-terminus(gene name synonym)|uniprotkb:MYO18A(gene name)|psi-mi:MYO18A(display_short)|uniprotkb:KIAA0216(gene name synonym)|uniprotkb:MYSPDZ(gene name synonym)|uniprotkb:CD245(gene name synonym)|uniprotkb:Surfactant protein receptor SP-R210(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	dip:DIP-46631N|ensembl:ENSG00000196535(gene)|ensembl:ENST00000527372(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016477"(cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042641"(actomyosin)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|go:"GO:1903028"(positive regulation of opsonization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR020587|interpro:IPR027417|interpro:IPR031244|interpro:IPR036034|interpro:IPR036064|interpro:IPR036961|interpro:IPR041489|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-9703465|refseq:NP_510880.2|refseq:NP_976063.1|refseq:NP_001333696.1|refseq:NP_001333697.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IunEYt79RO62wU6VU2gv16Xb7Lk9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46783	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354442|uniprotkb:Q5TZC0|uniprotkb:B2R4E3|ensembl:ENSP00000481646|ensembl:ENSP00000494190|ensembl:ENSP00000494440|ensembl:ENSP00000497917	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs10_human(display_long)|uniprotkb:RPS10(gene name)|psi-mi:RPS10(display_short)|uniprotkb:Small ribosomal subunit protein eS10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001005.1|refseq:NP_001190174.1|refseq:NP_001191020.1|ensembl:ENSG00000124614(gene)|ensembl:ENST00000464218(transcript)|ensembl:ENST00000467531(transcript)|ensembl:ENST00000621356(transcript)|ensembl:ENST00000648437(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR005326(Plectin/S10, N-terminal)|rcsb pdb:6G51|interpro:IPR036388|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|interpro:IPR037447|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|mint:P46783|rcsb pdb:4UG0|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:4V6X|rcsb pdb:6ZUO|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|rcsb pdb:5T2C|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GWUAJh7s0w/ar/SOpx0hiIJOr2c9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46109	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B7Z5V2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190263	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b7z5v2_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0042995"(cell projection)|interpro:IPR019749|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019747|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018980|interpro:IPR008954(Moesin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+vK2a20sO9KEUDpPbszDHGxJpOA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04264	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-298429|uniprotkb:Q14720|uniprotkb:Q6GSJ0|uniprotkb:B2RA01|uniprotkb:Q9H298|ensembl:ENSP00000252244|uniprotkb:P85925|uniprotkb:P86104	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c1_human(display_long)|uniprotkb:KRT1(gene name)|psi-mi:KRT1(display_short)|uniprotkb:KRTA(gene name synonym)|uniprotkb:Keratin-1(gene name synonym)|uniprotkb:Cytokeratin-1(gene name synonym)|uniprotkb:67 kDa cytokeratin(gene name synonym)|uniprotkb:Hair alpha protein(gene name synonym)|uniprotkb:Type-II keratin Kb1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006112.3|ensembl:ENSG00000167768(gene)|ensembl:ENST00000252244(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045095"(keratin filament)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR032449|interpro:IPR039008|mint:P04264|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6UUI|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TeAC3i2hWTS2lgXT0i4agp9nv349606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49915	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050289|uniprotkb:A8K639|uniprotkb:B4DXV7|uniprotkb:F8W720|ensembl:ENSP00000419851	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:guaa_human(display_long)|uniprotkb:GMP synthetase(gene name synonym)|uniprotkb:Glutamine amidotransferase(gene name synonym)|uniprotkb:GMPS(gene name)|psi-mi:GMPS(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003866.1|ensembl:ENSG00000163655(gene)|ensembl:ENST00000496455(transcript)|go:"GO:0003921"(GMP synthase activity)|go:"GO:0003922"("GMP synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0016462"(pyrophosphatase activity)|interpro:IPR001674(GMP synthase, C-terminal)|interpro:IPR004739(GMP synthase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017926|interpro:IPR022310|interpro:IPR025777|interpro:IPR029062|mint:P49915|rcsb pdb:2VPI|rcsb pdb:2VXO|reactome:R-HSA-73817	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LYs65bPoqjVG/ZxA6v+yJo3HsLI9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63010	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63000	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40926	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95782	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353552|uniprotkb:Q96CI7|uniprotkb:Q96PP6|uniprotkb:Q96PP7|uniprotkb:Q9H070|intact:EBI-28973302|ensembl:ENSP00000351926	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2a1_human(display_long)|uniprotkb:AP2A1(gene name)|psi-mi:AP2A1(display_short)|uniprotkb:ADTAA(gene name synonym)|uniprotkb:CLAPA1(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055018.2|refseq:NP_570603.2|ensembl:ENST00000354293|ensembl:ENSP00000346246|ensembl:ENSP00000351926|ensembl:ENSG00000196961(gene)|ensembl:ENST00000359032(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O95782|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|dip:DIP-33164N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:egkaIAhvIi1FqNr+8KEFeJaYZcc9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52597	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352986|ensembl:ENSP00000338477|ensembl:ENSP00000349573|ensembl:ENSP00000400433|ensembl:ENSP00000438061|ensembl:ENSP00000507787|ensembl:ENSP00000348345|uniprotkb:Q5T0N2|uniprotkb:Q96AU2|uniprotkb:B3KM84	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpf_human(display_long)|uniprotkb:HNRNPF(gene name)|psi-mi:HNRNPF(display_short)|uniprotkb:HNRPF(gene name synonym)|uniprotkb:Nucleolin-like protein mcs94-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P52597|rcsb pdb:2HGL|rcsb pdb:2HGM|rcsb pdb:2HGN|rcsb pdb:2KFY|rcsb pdb:2KG0|rcsb pdb:2KG1|rcsb pdb:3TFY|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000169813(gene)|ensembl:ENST00000337970(transcript)|ensembl:ENST00000356053(transcript)|ensembl:ENST00000357065(transcript)|ensembl:ENST00000443950(transcript)|ensembl:ENST00000544000(transcript)|ensembl:ENST00000682386(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001091674.1|refseq:NP_001091675.1|refseq:NP_001091676.1|refseq:NP_001091677.1|refseq:NP_001091678.1|refseq:NP_004957.1|dip:DIP-33145N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pblzpldZOa5vlZ+zGQY9qyWCxaw9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15020	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06748	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78579|uniprotkb:P08693|uniprotkb:Q12826|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q14115|uniprotkb:Q5EU94|uniprotkb:Q5EU95|uniprotkb:Q5EU96|uniprotkb:Q5EU97|uniprotkb:Q5EU98|uniprotkb:Q5EU99|uniprotkb:Q6V962|uniprotkb:Q8WTW5|uniprotkb:Q96AT6|uniprotkb:Q96DC4|uniprotkb:Q96EA5|uniprotkb:A8K3N7|uniprotkb:B5BU00|uniprotkb:Q9UDJ7|uniprotkb:D3DQL6|uniprotkb:Q9BYG9|ensembl:ENSP00000296930|ensembl:ENSP00000428755	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:npm_human(display_long)|uniprotkb:NPM1(gene name)|psi-mi:NPM1(display_short)|uniprotkb:NPM(gene name synonym)|uniprotkb:Nucleolar phosphoprotein B23(gene name synonym)|uniprotkb:Numatrin(gene name synonym)|uniprotkb:Nucleolar protein NO38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002511.1|refseq:NP_954654.1|refseq:NP_001032827.1|dip:DIP-30932N|ensembl:ENSG00000181163(gene)|ensembl:ENST00000296930(transcript)|ensembl:ENST00000517671(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001652"(granular component)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019843"(rRNA binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042255"(ribosome assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060699"(regulation of endoribonuclease activity)|go:"GO:0060735"(regulation of eIF2 alpha phosphorylation by dsRNA)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902629"(regulation of mRNA stability involved in cellular response to UV)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR032569|interpro:IPR036824|mint:P06748|rcsb pdb:2LLH|rcsb pdb:2P1B|rcsb pdb:2VXD|rcsb pdb:5EHD|reactome:R-HSA-180746|reactome:R-HSA-3899300|reactome:R-HSA-606279|reactome:R-HSA-6804115|reactome:R-HSA-8869496	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HJ7Mg+XsIhuJiScPKiI0dIa6KpM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7RTV0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2555365|uniprotkb:Q9UH06|ensembl:ENSP00000216252	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phf5a_human(display_long)|uniprotkb:Splicing factor 3B-associated 14 kDa protein(gene name synonym)|uniprotkb:PHF5A(gene name)|psi-mi:PHF5A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_116147.1|ensembl:ENSG00000100410(gene)|ensembl:ENST00000216252(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR005345(PHF5-like)|mint:Q7RTV0|rcsb pdb:5IFE|rcsb pdb:5O9Z|rcsb pdb:5SYB|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:5ZYA|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|go:"GO:0048863"(stem cell differentiation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TrngLk+KyJ+qRs8HGvH1LZH2Tsg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26038	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-528768|ensembl:ENSP00000353408	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15145	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351829|uniprotkb:O00554|ensembl:ENSP00000228825	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arpc3_human(display_long)|uniprotkb:ARPC3(gene name)|psi-mi:ARPC3(display_short)|uniprotkb:ARC21(gene name synonym)|uniprotkb:Arp2/3 complex 21 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000111229(gene)|ensembl:ENST00000228825(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031941"(filamentous actin)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0061850"(growth cone leading edge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR007204(ARP2/3 complex, 21 kDa p21-Arc subunit)|interpro:IPR036753|mint:O15145|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|refseq:NP_001274151.1|refseq:NP_001265485.1|dip:DIP-33187N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u4h1270mPo3E3GBrEurYtpUYTQM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60900	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357793|uniprotkb:P34062|uniprotkb:Q6IB60|uniprotkb:B2R7J9|uniprotkb:B4DQR4|uniprotkb:B4DXJ9|ensembl:ENSP00000261479	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa6_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short)|uniprotkb:PROS27(gene name synonym)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)|uniprotkb:27 kDa prosomal protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002782.1|refseq:NP_001269162.1|refseq:NP_001269163.1|refseq:XP_016876957.1|refseq:NP_001269161.1|ensembl:ENSG00000100902(gene)|ensembl:ENST00000261479(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0035639"(purine ribonucleoside triphosphate binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|mint:P60900|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29367N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23246	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35580	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62851	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353054|ensembl:ENSP00000435096|ensembl:ENSP00000486392|uniprotkb:P25111|uniprotkb:B2R4M7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs25_human(display_long)|uniprotkb:RPS25(gene name)|psi-mi:RPS25(display_short)|uniprotkb:Small ribosomal subunit protein eS25(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000118181(gene)|ensembl:ENSG00000280831(gene)|ensembl:ENST00000527673(transcript)|ensembl:ENST00000628770(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004977(Ribosomal protein S25)|interpro:IPR036388|mint:P62851|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y0G|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:6ZXD|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|rcsb pdb:6ZXE|reactome:R-HSA-9010553|reactome:R-HSA-9633012|rcsb pdb:6ZXF|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|refseq:NP_001019.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7TqA4Q6+6VMzrzaUrACbwtJKfOM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05556	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62750	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353254|uniprotkb:P29316|uniprotkb:Q92774|uniprotkb:P39024|uniprotkb:B2R5B2|ensembl:ENSP00000389103	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl23a_human(display_long)|uniprotkb:RPL23A(gene name)|psi-mi:RPL23A(display_short)|uniprotkb:Large ribosomal subunit protein uL23(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|refseq:NP_000975.2|ensembl:ENSG00000198242(gene)|ensembl:ENST00000422514(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904841"(TORC2 complex binding)|interpro:IPR001014(Ribosomal protein L23, conserved site)|interpro:IPR005633(Ribosomal protein L23/L25, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|interpro:IPR019985|mint:P62750|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lA1ubRFO9/Tl54Z1dKUzoCKvpAo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40939	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62081	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354360|uniprotkb:Q6IPH1|uniprotkb:P23821|uniprotkb:P24818|uniprotkb:Q57Z92|ensembl:ENSP00000385018|ensembl:ENSP00000385286|ensembl:ENSP00000495273|ensembl:ENSP00000496654|ensembl:ENSP00000496757	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs7_human(display_long)|uniprotkb:RPS7(gene name)|psi-mi:RPS7(display_short)|uniprotkb:Small ribosomal subunit protein eS7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002.1|ensembl:ENSG00000171863(gene)|ensembl:ENST00000403564(transcript)|ensembl:ENST00000406376(transcript)|ensembl:ENST00000462576(transcript)|ensembl:ENST00000645674(transcript)|ensembl:ENST00000646909(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000554(Ribosomal protein S7e)|mint:P62081|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6G4S	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l4aG6I34lmzYhNapbdv2CAAwRwg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25705	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00233	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750973|uniprotkb:Q9BQ42|uniprotkb:G3V1Q6|uniprotkb:B2RD35|intact:EBI-28988356|ensembl:ENSP00000440485	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd9_human(display_long)|uniprotkb:26S proteasome regulatory subunit p27(gene name synonym)|uniprotkb:PSMD9(gene name)|psi-mi:PSMD9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002804.2|refseq:NP_001248329.1|ensembl:ENST00000537407|ensembl:ENSP00000445058|ensembl:ENSP00000440485|ensembl:ENST00000542602|ensembl:ENSP00000443772|ensembl:ENSG00000110801(gene)|ensembl:ENST00000541212(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0070682"(proteasome regulatory particle assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR035269|interpro:IPR036034|interpro:IPR040815|interpro:IPR041489|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|go:"GO:0003713"(transcription coactivator activity)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OkUTrgO5lFTumVtMd+3vZTf3TPc9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62318	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372789|uniprotkb:P43331|uniprotkb:B5BU13|uniprotkb:B4DJP7|ensembl:ENSP00000215829|intact:EBI-10981086	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd3_human(display_long)|uniprotkb:SNRPD3(gene name)|psi-mi:SNRPD3(display_short)|uniprotkb:snRNP core protein D3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004166.1|refseq:NP_001265585.1|ensembl:ENSG00000100028(gene)|ensembl:ENST00000215829(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:0071209"(U7 snRNA binding)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034099|mint:P62318|rcsb pdb:1D3B|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-111367|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-73856|reactome:R-HSA-77588|rcsb pdb:7ABG|rcsb pdb:3VRI|rcsb pdb:4PJO|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:3PGW|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6V4X|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|dip:DIP-31216N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WkrSZVfVmSQrJYfy7mwp48xjsVA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14566	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30043	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2837485|uniprotkb:P53005|uniprotkb:P32078|uniprotkb:Q32LZ2|uniprotkb:B2R5C6|uniprotkb:A6NKD8|ensembl:ENSP00000263368	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:blvrb_human(display_long)|uniprotkb:BLVRB(gene name)|psi-mi:BLVRB(display_short)|uniprotkb:FLR(gene name synonym)|uniprotkb:Biliverdin reductase B(gene name synonym)|uniprotkb:Biliverdin-IX beta-reductase(gene name synonym)|uniprotkb:Green heme-binding protein(gene name synonym)|uniprotkb:NADPH-dependent diaphorase(gene name synonym)|uniprotkb:NADPH-flavin reductase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000704.1|ensembl:ENSG00000090013(gene)|ensembl:ENST00000263368(transcript)|go:"GO:0004074"("biliverdin reductase (NAD(P)+) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042602"("riboflavin reductase (NADPH) activity")|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106276"(biliberdin reductase NAD+ activity)|go:"GO:0106277"("biliverdin reductase (NADP+) activity")|interpro:IPR016040("NAD(P)-binding")|interpro:IPR036291|rcsb pdb:1HDO|rcsb pdb:1HE2|rcsb pdb:1HE3|rcsb pdb:1HE4|rcsb pdb:1HE5|rcsb pdb:5OOG|rcsb pdb:5OOH|rcsb pdb:6OPL|reactome:R-HSA-189483|reactome:R-HSA-9707564	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dAGhnUTdZxBN2cUpArtdmrVdeKw9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51148	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62910	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-438408|ensembl:ENSP00000380156|ensembl:ENSP00000380158|ensembl:ENSP00000388674|ensembl:ENSP00000416429|uniprotkb:P02433|uniprotkb:B2R4Q3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl32_human(display_long)|uniprotkb:RPL32(gene name)|psi-mi:RPL32(display_short)|uniprotkb:Large ribosomal subunit protein eL32(gene name synonym)|uniprotkb:PP9932(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000144713(gene)|ensembl:ENST00000396953(transcript)|ensembl:ENST00000396957(transcript)|ensembl:ENST00000429711(transcript)|ensembl:ENST00000435983(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR001515(Ribosomal protein L32e)|interpro:IPR018263|interpro:IPR036351|mint:P62910|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000985.1|refseq:NP_001007074.1|refseq:NP_001007075.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Yhph2ETzWYd07yJcq1cVqsSRjo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13155	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745226|uniprotkb:Q75MR1|uniprotkb:Q96CZ5|uniprotkb:Q9P1L2|ensembl:ENSP00000223029|uniprotkb:F8W950	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:aimp2_human(display_long)|uniprotkb:Protein JTV-1(gene name synonym)|uniprotkb:AIMP2(gene name)|psi-mi:AIMP2(display_short)|uniprotkb:PRO0992(orf name)|uniprotkb:JTV1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006294.2|ensembl:ENSG00000106305(gene)|ensembl:ENST00000223029(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903632"(positive regulation of aminoacyl-tRNA ligase activity)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR031889|interpro:IPR036282|interpro:IPR041503|interpro:IPR042360|mint:Q13155|rcsb pdb:4DPG|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5Y6L|rcsb pdb:6ILD|rcsb pdb:6IY6|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-34421N|refseq:NP_001313536.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VEBmJjo6t3dBY6mKpmUyVLamJFQ9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11388	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q1WWK5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190162	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q1wwk5_human(display_long)|uniprotkb:SEPT9(gene name)|psi-mi:SEPT9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005525"(GTP binding)|interpro:IPR027417|interpro:IPR030645	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:80HBLhdKw7dQlez8rvVWnMBquJM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30048	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748336|intact:EBI-10975142|uniprotkb:P35690|uniprotkb:Q0D2H1|uniprotkb:Q13776|uniprotkb:Q5T5V2|uniprotkb:Q96HK4|uniprotkb:B2R7Z0|uniprotkb:D3DRC9|uniprotkb:E9PH29|ensembl:ENSP00000298510	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx3_human(display_long)|uniprotkb:Peroxiredoxin-3(gene name synonym)|uniprotkb:Peroxiredoxin III(gene name synonym)|uniprotkb:Antioxidant protein 1(gene name synonym)|uniprotkb:Protein MER5 homolog(gene name synonym)|uniprotkb:HBC189(gene name synonym)|uniprotkb:PRDX3(gene name)|psi-mi:PRDX3(display_short)|uniprotkb:AOP1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001289201.1|refseq:NP_006784.1|ensembl:ENSG00000165672(gene)|ensembl:ENST00000298510(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008785"(alkyl hydroperoxide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:P30048|rcsb pdb:5JCG|rcsb pdb:5UCX|reactome:R-HSA-3299685|go:"GO:0005769"(early endosome)|dip:DIP-33600N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+J/zV8u0jGCSzTGXafxgecTv/149606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12906	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61158	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351428|uniprotkb:P32391|ensembl:ENSP00000263238|uniprotkb:Q53QM2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arp3_human(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005712.1|ensembl:ENSG00000115091(gene)|ensembl:ENST00000263238(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:P61158|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33140N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28066	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355475|uniprotkb:B4E2V4|uniprotkb:Q6IBF7|uniprotkb:Q3T1C1|uniprotkb:B2R8F6|ensembl:ENSP00000271308	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa5_human(display_long)|uniprotkb:PSMA5(gene name)|psi-mi:PSMA5(display_short)|uniprotkb:Proteasome zeta chain(gene name synonym)|uniprotkb:Macropain zeta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex zeta chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186701.1|refseq:NP_001186702.1|refseq:NP_001186703.1|refseq:NP_002781.2|ensembl:ENSG00000143106(gene)|ensembl:ENST00000271308(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR033812|mint:P28066|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEY|rcsb pdb:5LEX|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29368N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfMG3npzVetUH1tahr2MAI4R+3g9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12905	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357925|uniprotkb:A6NDB0|uniprotkb:Q5SR10|uniprotkb:Q5SR11|uniprotkb:Q7L7R3|uniprotkb:Q9BWD4|uniprotkb:Q9P1N0|uniprotkb:B2R8G7|ensembl:ENSP00000355011	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ilf2_human(display_long)|uniprotkb:PRO3063(orf name)|uniprotkb:NF45(gene name synonym)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004506.2|refseq:NP_001254738.1|ensembl:ENSG00000143621(gene)|ensembl:ENST00000361891(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q12905|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61254	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352405|uniprotkb:Q02877|uniprotkb:Q6IPY2|uniprotkb:B2R4F0|uniprotkb:D3DTR8|ensembl:ENSP00000462322|ensembl:ENSP00000463470|ensembl:ENSP00000463784|ensembl:ENSP00000498177	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl26_human(display_long)|uniprotkb:RPL26(gene name)|psi-mi:RPL26(display_short)|uniprotkb:Large ribosomal subunit protein uL24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000978.1|refseq:NP_001302459.1|refseq:NP_001302460.1|ensembl:ENST00000582556(transcript)|ensembl:ENST00000583011(transcript)|ensembl:ENST00000584164(transcript)|ensembl:ENST00000648839(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|ensembl:ENSG00000161970(gene)|go:"GO:0022626"(cytosolic ribosome)|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:1902164"(positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1904803"(regulation of translation involved in cellular response to UV)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005756(Ribosomal protein L26, eukaryotic/archaeal)|interpro:IPR005824(KOW)|interpro:IPR005825(Ribosomal protein L24/L26, conserved site)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041988|mint:P61254|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|go:"GO:0034644"(cellular response to UV)|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|rcsb pdb:5LKS|reactome:R-HSA-156827|dip:DIP-33198N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VAROWOFmYvolVgc/e5E1jAmNuaY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17096	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746843|uniprotkb:P10910|uniprotkb:Q9UKB0|uniprotkb:Q5T6U9|ensembl:ENSP00000308227|ensembl:ENSP00000399888	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmga1_human(display_long)|uniprotkb:High mobility group AT-hook protein 1(gene name synonym)|uniprotkb:HMGA1(gene name)|psi-mi:HMGA1(display_short)|uniprotkb:HMGIY(gene name synonym)|uniprotkb:High mobility group protein R(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002122.1|refseq:NP_665906.1|refseq:NP_665908.1|refseq:NP_665909.1|refseq:NP_665910.1|refseq:NP_665912.1|refseq:NP_001306006.1|refseq:NP_001306007.1|refseq:NP_001306008.1|refseq:NP_001306009.1|refseq:NP_001306010.1|refseq:NP_001306011.1|ensembl:ENSG00000137309(gene)|ensembl:ENST00000311487(transcript)|ensembl:ENST00000447654(transcript)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030527"(structural constituent of chromatin)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR000116(High mobility group, HMG-I and HMG-Y)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR017956|interpro:IPR031079|mint:P17096|rcsb pdb:2EZD|rcsb pdb:2EZE|rcsb pdb:2EZF|rcsb pdb:2EZG|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|reactome:R-HSA-2559584|dip:DIP-29687N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hhCMZ6CUf3e+PD0RNIauCZ8EThM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62249	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352480|uniprotkb:P17008|uniprotkb:B2RDD5|ensembl:ENSP00000251453	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs16_human(display_long)|uniprotkb:RPS16(gene name)|psi-mi:RPS16(display_short)|uniprotkb:Small ribosomal subunit protein uS9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001011.1|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000105193(gene)|ensembl:ENST00000251453(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097421"(liver regeneration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P62249|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|dip:DIP-33200N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OrKriR6HsATLaO+drdUa2w3Gpd09606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62854	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353438|uniprotkb:P02383|uniprotkb:Q3MHD8|uniprotkb:P70394|uniprotkb:Q06722|uniprotkb:Q6IRY4|ensembl:ENSP00000348849|ensembl:ENSP00000450339|ensembl:ENSP00000496643	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs26_human(display_long)|uniprotkb:RPS26(gene name)|psi-mi:RPS26(display_short)|uniprotkb:Small ribosomal subunit protein eS26(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001020.2|refseq:XP_005276741.1|rcsb pdb:6OLG|rcsb pdb:6OLF|ensembl:ENST00000356464(transcript)|ensembl:ENST00000552361(transcript)|ensembl:ENST00000646449(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR000892(Ribosomal protein S26e)|interpro:IPR038551|mint:P62854|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6G5H|ensembl:ENSG00000197728(gene)|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-156827	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bo2ruYMNjjLCMo/kwAWzmlJrrjU9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13263	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8IX12	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356265|ensembl:ENSP00000265872|uniprotkb:A0JLT7|uniprotkb:A1L4P7|uniprotkb:A8K9D4|uniprotkb:B4DNP8|uniprotkb:B4DRK8|uniprotkb:Q5EBM3|uniprotkb:Q32NE3|uniprotkb:Q5VUP6|uniprotkb:Q6PIZ0|uniprotkb:Q6X935|uniprotkb:Q9H8N4|uniprotkb:Q9NVA7|uniprotkb:Q9NVQ0|uniprotkb:Q9NWM6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ccar1_human(display_long)|uniprotkb:CCAR1(gene name)|psi-mi:CCAR1(display_short)|uniprotkb:CARP1(gene name synonym)|uniprotkb:DIS(gene name synonym)|uniprotkb:Cell cycle and apoptosis regulatory protein 1(gene name synonym)|uniprotkb:Death inducer with SAP domain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000060339(gene)|ensembl:ENST00000265872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR011992(EF-Hand type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR036361|mint:Q8IX12|reactome:R-HSA-72163|refseq:NP_060707.2|refseq:NP_001269888.1|refseq:NP_001269889.1|dip:DIP-27607N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YnZve7StC4kAO8raUbp8T02jpe09606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13645	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-465144|ensembl:ENSP00000269576|uniprotkb:Q14664|uniprotkb:Q8N175	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c10_human(display_long)|uniprotkb:KRT10(gene name)|psi-mi:KRT10(display_short)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:KPP(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000186395(gene)|ensembl:ENST00000269576(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P13645|rcsb pdb:3ASW|rcsb pdb:4F1Z|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6EC0|rcsb pdb:6UUI|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000412.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:z100yyq3b63P0ARy2lE2ELyJeik9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51532	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302489|uniprotkb:O95052|uniprotkb:Q9HBD3|uniprotkb:B1A8Z4|uniprotkb:B1A8Z5|uniprotkb:B1A8Z6|uniprotkb:B1A8Z7|uniprotkb:E9PBR8|ensembl:ENSP00000343896|ensembl:ENSP00000395654	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smca4_human(display_long)|uniprotkb:SMARCA4(gene name)|psi-mi:SMARCA4(display_short)|uniprotkb:BRG1(gene name synonym)|uniprotkb:SNF2B(gene name synonym)|uniprotkb:SNF2L4(gene name synonym)|uniprotkb:ATP-dependent helicase SMARCA4(gene name synonym)|uniprotkb:SNF2-beta(gene name synonym)|uniprotkb:BAF190A(gene name synonym)|uniprotkb:Mitotic growth and transcription activator(gene name synonym)|uniprotkb:Protein BRG-1(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4(gene name synonym)|uniprotkb:Protein brahma homolog 1(gene name synonym)|uniprotkb:BRG1-associated factor 190A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001122316.1|refseq:NP_003063.2|refseq:NP_001122317.1|refseq:NP_001122318.1|refseq:NP_001122319.1|refseq:NP_001122320.1|dip:DIP-24249N|refseq:XP_016882654.1|refseq:XP_016882655.1|refseq:XP_016882656.1|refseq:XP_016882657.1|ensembl:ENSG00000127616(gene)|ensembl:ENST00000344626(transcript)|ensembl:ENST00000429416(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0002039"(p53 binding)|go:"GO:0003407"(neural retina development)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030100|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51532|rcsb pdb:2GRC|rcsb pdb:2H60|rcsb pdb:3UVD|rcsb pdb:5DKD|rcsb pdb:5EA1|rcsb pdb:6BGH|rcsb pdb:6HR2|rcsb pdb:6LTH|rcsb pdb:6LTJ|rcsb pdb:6SY2|rcsb pdb:6ZS2|reactome:R-HSA-1266695|reactome:R-HSA-201722|reactome:R-HSA-3214858|reactome:R-HSA-3247509|reactome:R-HSA-8939243|reactome:R-HSA-9619665	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ztr+2IXfAxueSUaNYG2A47HoMes9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12829	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222789|uniprotkb:P11783|uniprotkb:D3DXJ7|ensembl:ENSP00000347055|ensembl:ENSP00000377096|ensembl:ENSP00000461570	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myl4_human(display_long)|uniprotkb:MYL4(gene name)|psi-mi:MYL4(display_short)|uniprotkb:MLC1(gene name synonym)|uniprotkb:PRO1957(orf name)|uniprotkb:Myosin light chain 1, embryonic muscle/atrial isoform(gene name synonym)|uniprotkb:Myosin light chain alkali GT-1 isoform(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002841.1|refseq:NP_002467.1|refseq:XP_005257448.1|ensembl:ENSG00000198336(gene)|ensembl:ENST00000354968(transcript)|ensembl:ENST00000393450(transcript)|ensembl:ENST00000572316(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0016459"(myosin complex)|go:"GO:0031672"(A band)|go:"GO:0032038"(myosin II heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|reactome:R-HSA-390522	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uoEY8vvAP2xDNz2TaBNrnxKFSGI9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75955	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3U8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057689|uniprotkb:Q6FIG1|uniprotkb:Q9UQF6|uniprotkb:B2R4Y1|uniprotkb:D6W634|ensembl:ENSP00000252543|ensembl:ENSP00000378081|ensembl:ENSP00000462609|ensembl:ENSP00000464342	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl36_human(display_long)|uniprotkb:RPL36(gene name)|psi-mi:RPL36(display_short)|uniprotkb:Large ribosomal subunit protein eL36(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056229.2|refseq:NP_378669.1|reactome:R-HSA-975957|mint:Q9Y3U8|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|interpro:IPR038097|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|rcsb pdb:6Y6X|ensembl:ENSG00000130255(gene)|ensembl:ENST00000347512(transcript)|ensembl:ENST00000394580(transcript)|ensembl:ENST00000577222(transcript)|ensembl:ENST00000579649(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000509(Ribosomal protein L36e)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lRlRMF2jV/UHr4SX95SSCFIEV+s9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61225	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750871|uniprotkb:P17964|uniprotkb:Q96EG5|uniprotkb:Q9CXG0|ensembl:ENSP00000319096	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rap2b_human(display_long)|uniprotkb:RAP2B(gene name)|psi-mi:RAP2B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002877.2|ensembl:ENSG00000181467(gene)|ensembl:ENST00000323534(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0035579"(specific granule membrane)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dFHHIYuDf3lTGSX0Nys6IE9ONvs9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00567	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-396034|uniprotkb:Q2M3T6|uniprotkb:Q9NQ05|ensembl:ENSP00000370589	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nop56_human(display_long)|uniprotkb:NOP56(gene name)|psi-mi:NOP56(display_short)|uniprotkb:NOL5A(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006383.2|ensembl:ENSG00000101361(gene)|ensembl:ENST00000329276(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:O00567|reactome:R-HSA-390471|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nXIsxj5Spl+kflK0yGJFykVylmA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P0L0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4DKZ6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190845	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4dkz6_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000347"(THO complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|interpro:IPR032302|interpro:IPR021418|interpro:IPR021726|interpro:IPR040007	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YylX+q+OBzcU2jw2I/I1tV+uRYU9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14697	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08754	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357563|uniprotkb:Q5TZX1|uniprotkb:P17539|ensembl:ENSP00000358867	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gnai3_human(display_long)|uniprotkb:GNAI3(gene name)|psi-mi:GNAI3(display_short)|uniprotkb:"G(i) alpha-3"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006487.1|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|ensembl:ENSG00000065135(gene)|ensembl:ENST00000369851(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:2IHB|rcsb pdb:2ODE|rcsb pdb:2V4Z|rcsb pdb:4G5O|rcsb pdb:4G5R|rcsb pdb:4G5S|rcsb pdb:7E9H|rcsb pdb:7KH0|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9009391|reactome:R-HSA-9660821	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:npLeIXVzrV8y0trCCII5rivIRYQ9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UBC2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2556746|intact:EBI-28972990|ensembl:ENSP00000248070|uniprotkb:B4DKA3|uniprotkb:A2RRF3|uniprotkb:A5PL29	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ep15r_human(display_long)|uniprotkb:EPS15R(gene name synonym)|uniprotkb:Eps15-related protein(gene name synonym)|uniprotkb:EPS15L1(gene name)|psi-mi:EPS15L1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_067058.1|ensembl:ENSP00000248070|ensembl:ENST00000455140|ensembl:ENSP00000393313|ensembl:ENST00000535753|ensembl:ENSP00000440103|ensembl:ENST00000597937|ensembl:ENSP00000472267|ensembl:ENST00000602022|ensembl:ENSP00000471981|ensembl:ENSG00000127527(gene)|ensembl:ENST00000248070(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0045296"(cadherin binding)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q9UBC2|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0030132"(clathrin coat of coated pit)|refseq:NP_001245303.1|refseq:NP_001245304.1|refseq:NP_001245305.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6Bsao5czetxRxIiy3O/rZox4U+Y9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07195	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62847	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354515|uniprotkb:P16632|uniprotkb:Q7Z3D1|uniprotkb:Q5T0P7|uniprotkb:Q5T0P8|uniprotkb:E7EPK6|ensembl:ENSP00000478869	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs24_human(display_long)|uniprotkb:RPS24(gene name)|psi-mi:RPS24(display_short)|uniprotkb:Small ribosomal subunit protein eS24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001135757.1|refseq:NP_001017.1|refseq:NP_001135755.1|refseq:NP_148982.1|ensembl:ENSG00000138326(gene)|ensembl:ENST00000613865(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001976(Ribosomal protein S24e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR018098|mint:P62847|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6XA1|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M/qkRxabHx9PFaOM7EwKDOOwu7Q9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00291	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P84098	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-916524|uniprotkb:P14118|uniprotkb:P22908|uniprotkb:Q502Y6|uniprotkb:Q7Z6E4|uniprotkb:B2R4K2|ensembl:ENSP00000225430	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl19_human(display_long)|uniprotkb:RPL19(gene name)|psi-mi:RPL19(display_short)|uniprotkb:Large ribosomal subunit protein eL19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000972.1|ensembl:ENSG00000108298(gene)|ensembl:ENST00000225430(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000196(Ribosomal protein L19/L19e)|interpro:IPR015972(Ribosomal protein L19/L19e, domain 1)|interpro:IPR023638|interpro:IPR033935|interpro:IPR035970|interpro:IPR039547|mint:P84098|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sYEwdB8ySbxh3iL0uqlfRRVFiWw9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31483	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q7Z5G4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4403685|ensembl:ENSP00000350378|ensembl:ENSP00000429329|ensembl:ENSP00000429480|uniprotkb:D3DSX9|uniprotkb:Q96EQ4|uniprotkb:Q9P1S0|uniprotkb:Q9Y5U7|uniprotkb:J3KQ24	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:goga7_human(display_long)|uniprotkb:GOLGA7(gene name)|psi-mi:GOLGA7(display_short)|uniprotkb:GCP16(gene name synonym)|uniprotkb:Golgi complex-associated protein of 16 kDa(gene name synonym)|uniprotkb:HDCKB03P(orf name)|uniprotkb:HSPC041(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000147533(gene)|ensembl:ENST00000357743(transcript)|ensembl:ENST00000518270(transcript)|ensembl:ENST00000520817(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002178"(palmitoyltransferase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005795"(Golgi stack)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0018230"(peptidyl-L-cysteine S-palmitoylation)|go:"GO:0031228"(intrinsic component of Golgi membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR019383|reactome:R-HSA-6798695|reactome:R-HSA-9648002|refseq:NP_001002296.1|refseq:NP_057183.2|refseq:NP_001167595.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NV93lzMDdykrGhl0NkCKYso0t+A9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26196	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60468	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07947	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08243	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722989|uniprotkb:P08184|uniprotkb:Q15666|uniprotkb:Q549T9|uniprotkb:Q96HD0|ensembl:ENSP00000175506|ensembl:ENSP00000377845|ensembl:ENSP00000377846|uniprotkb:A4D1I8|uniprotkb:D6W5R3|uniprotkb:B4DXZ1|uniprotkb:B7ZAA9|uniprotkb:E9PCI3|uniprotkb:E9PCX6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:asns_human(display_long)|uniprotkb:Glutamine-dependent asparagine synthetase(gene name synonym)|uniprotkb:Cell cycle control protein TS11(gene name synonym)|uniprotkb:ASNS(gene name)|psi-mi:ASNS(display_short)|uniprotkb:TS11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001171546.1|refseq:NP_001171547.1|refseq:NP_001171548.1|refseq:NP_001664.3|refseq:NP_597680.2|refseq:NP_899199.2|ensembl:ENSG00000070669(gene)|ensembl:ENST00000175506(transcript)|ensembl:ENST00000394308(transcript)|ensembl:ENST00000394309(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004066"("asparagine synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006529"(asparagine biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032354"(response to follicle-stimulating hormone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0070981"(L-asparagine biosynthetic process)|interpro:IPR001962(Asparagine synthase)|interpro:IPR006426(Asparagine synthase, glutamine-hydrolyzing)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017932|interpro:IPR029055|interpro:IPR033738|rcsb pdb:6GQ3|reactome:R-HSA-380994|reactome:R-HSA-8963693|reactome:R-HSA-9633012|reactome:R-HSA-9648895	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:McR8Ve0DzWhe3JWMYLsCRChiBaY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75477	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359299|uniprotkb:B0QZ42|uniprotkb:Q53HV0|ensembl:ENSP00000384900|ensembl:ENSP00000410964|intact:EBI-21351077|uniprotkb:D3DR65	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:erln1_human(display_long)|uniprotkb:KEO4(gene name synonym)|uniprotkb:ERLIN1(gene name)|psi-mi:ERLIN1(display_short)|uniprotkb:C10orf69(gene name synonym)|uniprotkb:KE04(gene name synonym)|uniprotkb:SPFH1(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 1(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1(gene name synonym)|uniprotkb:Protein KE04(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001094096.1|refseq:NP_006450.2|ensembl:ENSG00000107566(gene)|ensembl:ENST00000407654(transcript)|ensembl:ENST00000421367(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O75477|reactome:R-HSA-382556|reactome:R-HSA-5678895|refseq:NP_001334786.1|refseq:NP_001334788.1|refseq:NP_001334789.1|refseq:NP_001334790.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HycFhL5qL5GLmaIIc9NtTcBbu1M9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02878	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359655|uniprotkb:Q2M3Q3|uniprotkb:Q8WW97|ensembl:ENSP00000202773|ensembl:ENSP00000403172	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl6_human(display_long)|uniprotkb:RPL6(gene name)|psi-mi:RPL6(display_short)|uniprotkb:TXREB1(gene name synonym)|uniprotkb:Tax-responsive enhancer element-binding protein 107(gene name synonym)|uniprotkb:Neoplasm-related protein C140(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000961.2|refseq:NP_001019833.1|ensembl:ENSG00000089009(gene)|ensembl:ENST00000202773(transcript)|ensembl:ENST00000424576(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR000915(Ribosomal protein L6E)|interpro:IPR005568(Ribosomal protein L6, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041997|mint:Q02878|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001307066.1|refseq:NP_001307067.1|refseq:NP_001307068.1|refseq:NP_001307069.1|refseq:NP_001307070.1|refseq:XP_016875270.1|refseq:XP_016875271.1|dip:DIP-27547N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y7fx3ToInzucV2QmI8KLSdHxai09606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60660	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-300817|uniprotkb:P16475|uniprotkb:P24572|uniprotkb:P24573|uniprotkb:Q12790|ensembl:ENSP00000446955|ensembl:ENSP00000448101|uniprotkb:Q6IAZ0|uniprotkb:Q6IPY5|uniprotkb:Q561V9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myl6_human(display_long)|uniprotkb:MYL6(gene name)|psi-mi:MYL6(display_short)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6(gene name synonym)|uniprotkb:Myosin light chain alkali 3(gene name synonym)|uniprotkb:Myosin light chain 3(gene name synonym)|uniprotkb:17 kDa myosin light chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000092841(gene)|ensembl:ENST00000548293(transcript)|ensembl:ENST00000550697(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|mint:P60660|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:NP_066299.2|refseq:NP_524147.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LhE3NUqcuHlOla13C0vjnFZfzy89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92616	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356221|ensembl:ENSP00000300648|uniprotkb:O95001|uniprotkb:O95651|uniprotkb:Q6P2S3|uniprotkb:Q86X65|uniprotkb:Q8N5I5|uniprotkb:Q8WU80|uniprotkb:Q99736|uniprotkb:Q9UE60|uniprotkb:A8KAY1|intact:EBI-1058692	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gcn1_human(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)|uniprotkb:GCN1-like protein 1(gene name synonym)|uniprotkb:GCN1L1(gene name synonym)|uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)|uniprotkb:KIAA0219(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000089154(gene)|ensembl:ENST00000300648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085|mint:Q92616|reactome:R-HSA-9633012|go:"GO:0005844"(polysome)|refseq:NP_006827.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NtSEW6xjvCkUyb40cnk0JdL5PcA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8NI36	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2512413|ensembl:ENSP00000423067|ensembl:ENSP00000479950|uniprotkb:A2RUS4|uniprotkb:Q8N1Q2|uniprotkb:Q68E02	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:wdr36_human(display_long)|uniprotkb:WDR36(gene name)|psi-mi:WDR36(display_short)|uniprotkb:T-cell activation WD repeat-containing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134987(gene)|ensembl:ENST00000506538(transcript)|ensembl:ENST00000612402(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007601"(visual perception)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|go:"GO:0050896"(response to stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR007319(Small-subunit processome, Utp21)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|refseq:NP_644810.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:97Qc0ehUPTjCBcn3gjr0FY8Nnus9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92522	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876335|ensembl:ENSP00000329662	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h1x_human(display_long)|uniprotkb:H1-10(gene name)|psi-mi:H1-10(display_short)|uniprotkb:H1FX(gene name synonym)|uniprotkb:Histone H1x(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000184897(gene)|ensembl:ENST00000333762(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045296"(cadherin binding)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:Q92522|refseq:NP_006017.1|dip:DIP-36358N|rcsb pdb:2LSO|rcsb pdb:6L9Z|rcsb pdb:7K60|rcsb pdb:7K63	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T+NweCoHXj0rYsS6gJ4V42R9MpA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60231	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-311446|uniprotkb:O60322|uniprotkb:Q969X7|uniprotkb:Q96QC1|uniprotkb:Q5JP45|ensembl:ENSP00000365625|ensembl:ENSP00000373071|ensembl:ENSP00000389862|ensembl:ENSP00000390938|ensembl:ENSP00000393958|ensembl:ENSP00000396193|ensembl:ENSP00000408956	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx16_human(display_long)|uniprotkb:DHX16(gene name)|psi-mi:DHX16(display_short)|uniprotkb:DBP2(gene name synonym)|uniprotkb:DDX16(gene name synonym)|uniprotkb:KIAA0577(gene name synonym)|uniprotkb:DEAH-box protein 16(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #3(gene name synonym)|uniprotkb:PRP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001157711.1|refseq:NP_003578.2|ensembl:ENSG00000204560(gene)|ensembl:ENSG00000206486(gene)|ensembl:ENSG00000226171(gene)|ensembl:ENSG00000231377(gene)|ensembl:ENSG00000233049(gene)|ensembl:ENSG00000233418(gene)|ensembl:ENSG00000233561(gene)|ensembl:ENST00000376442(transcript)|ensembl:ENST00000383577(transcript)|ensembl:ENST00000417308(transcript)|ensembl:ENST00000421095(transcript)|ensembl:ENST00000424672(transcript)|ensembl:ENST00000451456(transcript)|ensembl:ENST00000458094(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF7|rcsb pdb:7DVQ|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sYCQp3qc9+wukR7aCf2qen2dgdU9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46940	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12770	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190187|ensembl:ENSP00000265565|ensembl:ENSP00000497087|uniprotkb:Q8N2E0|uniprotkb:Q8WUA1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:scap_human(display_long)|uniprotkb:SCAP(gene name)|psi-mi:SCAP(display_short)|uniprotkb:KIAA0199(gene name synonym)|uniprotkb:PSEC0227(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114650(gene)|ensembl:ENST00000648151(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032934"(sterol binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|ensembl:ENST00000265565(transcript)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030225|interpro:IPR036322|mint:Q12770|rcsb pdb:6M49|rcsb pdb:7ETW|reactome:R-HSA-1655829|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|refseq:XP_011531803.1|refseq:NP_036367.2|refseq:XP_016861407.1|refseq:XP_016861410.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bhavwLS6XzkZpAoBhCsII97JfpI9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27816	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715255|uniprotkb:Q59FT2|uniprotkb:Q68D74|uniprotkb:Q6ZUW9|uniprotkb:Q96NS9|uniprotkb:Q13082|uniprotkb:Q96A76|ensembl:ENSP00000353375|uniprotkb:Q86V26	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:map4_human(display_long)|uniprotkb:MAP4(gene name)|psi-mi:MAP4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001127836.1|refseq:NP_002366.2|ensembl:ENSG00000047849(gene)|ensembl:ENST00000360240(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR027323|mint:P27816|refseq:NP_112147.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rBf82W3kFCo+2UklK5WHO3MWjV09606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61981	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12931	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1045046|uniprotkb:Q86YC1|uniprotkb:A6H8X3|ensembl:ENSP00000285968	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu205_human(display_long)|uniprotkb:Nucleoporin Nup205(gene name synonym)|uniprotkb:205 kDa nucleoporin(gene name synonym)|uniprotkb:NUP205(gene name)|psi-mi:NUP205(display_short)|uniprotkb:C7orf14(gene name synonym)|uniprotkb:KIAA0225(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000155561(gene)|ensembl:ENST00000285968(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|interpro:IPR021827|mint:Q92621|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:NP_055950.1|refseq:NP_001316363.1|dip:DIP-44021N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5lulE2tOZ4V1UZPwkEvOo9reZWE9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55196	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-365875|uniprotkb:O75089|uniprotkb:Q5TIG6|uniprotkb:O75087|uniprotkb:O75088|uniprotkb:Q9NSN7|uniprotkb:Q9NU92|uniprotkb:Q5TIG7|uniprotkb:Q59FP0|ensembl:ENSP00000404595	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:afad_human(display_long)|uniprotkb:AFDN(gene name)|psi-mi:AFDN(display_short)|uniprotkb:AF6(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 6 protein(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:MLLT4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035089.1|refseq:NP_001193937.1|refseq:XP_005267053.1|ensembl:ENST00000392108|ensembl:ENSP00000375956|ensembl:ENST00000392112|ensembl:ENSP00000375960|ensembl:ENST00000400822|ensembl:ENSP00000383623|ensembl:ENSP00000404595|refseq:NP_001278893.1|ensembl:ENSG00000130396(gene)|ensembl:ENST00000447894(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|interpro:IPR036034|interpro:IPR037977|mint:P55196|rcsb pdb:1T2M|rcsb pdb:1XZ9|rcsb pdb:2AIN|rcsb pdb:2EXG|rcsb pdb:5A6C|reactome:R-HSA-418990|go:"GO:0022409"(positive regulation of cell-cell adhesion)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x7kK5K1+wAFZFdVopvQ/l496J5U9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60842	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73449|uniprotkb:P04765|uniprotkb:Q5U018|uniprotkb:Q61516|uniprotkb:B2R6L8|uniprotkb:D3DTP9|uniprotkb:J3QLC4|ensembl:ENSP00000293831	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4a1_human(display_long)|uniprotkb:EIF4A1(gene name)|psi-mi:EIF4A1(display_short)|uniprotkb:EIF4A(gene name synonym)|uniprotkb:DDX2A(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001407.1|refseq:NP_001191439.1|dip:DIP-29755N|ensembl:ENSG00000161960(gene)|ensembl:ENST00000293831(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P60842|rcsb pdb:2G9N|rcsb pdb:2ZU6|rcsb pdb:3EIQ|rcsb pdb:5ZBZ|rcsb pdb:5ZC9|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e+2gp47oHrpxFbrBFSM4qTf3r7E9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14315	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46778	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350634|uniprotkb:Q16699|ensembl:ENSP00000346027|ensembl:ENSP00000351021|ensembl:ENSP00000370569|ensembl:ENSP00000370574	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl21_human(display_long)|uniprotkb:RPL21(gene name)|psi-mi:RPL21(display_short)|uniprotkb:Large ribosomal subunit protein eL21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6LU8|refseq:NP_000973.2|ensembl:ENSG00000122026(gene)|ensembl:ENST00000272274(transcript)|ensembl:ENST00000311549(transcript)|ensembl:ENST00000319826(transcript)|ensembl:ENST00000326092(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001147(Ribosomal protein L21e)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:P46778|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6OLE|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UCth+WL9Oj1Y9I5m4i/9X0a5WHk9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28072	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01082	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351561|intact:EBI-1642531|uniprotkb:O60837|uniprotkb:Q16057|uniprotkb:Q53R99|uniprotkb:Q59ER3|uniprotkb:Q8IX99|uniprotkb:B2RP63|ensembl:ENSP00000349259	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sptb2_human(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:SPTB2(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 1(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003119.2|refseq:NP_842565.2|ensembl:ENSG00000115306(gene)|ensembl:ENST00000356805(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q01082|rcsb pdb:1AA2|rcsb pdb:1BKR|rcsb pdb:3EDV|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9703465|reactome:R-HSA-373753|refseq:XP_005264574.1|refseq:XP_006712150.1|refseq:XP_016860268.1|refseq:XP_016860269.1|refseq:XP_016860270.1|dip:DIP-33182N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rQJxsoEirg87umLjsEwHcQ0/blQ9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25205	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49591	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053431|uniprotkb:Q5T5C8|uniprotkb:Q9NSE3|uniprotkb:B2R6Y9|ensembl:ENSP00000234677	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sysc_human(display_long)|uniprotkb:SARS1(gene name)|psi-mi:SARS1(display_short)|uniprotkb:SARS(gene name synonym)|uniprotkb:SERS(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006504.2|ensembl:ENSG00000031698(gene)|ensembl:ENST00000234677(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:1904046"(negative regulation of vascular endothelial growth factor production)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR015866(Seryl-tRNA synthetase, class IIa, N-terminal)|interpro:IPR033729|interpro:IPR042103|rcsb pdb:3VBB|rcsb pdb:4L87|rcsb pdb:4RQE|rcsb pdb:4RQF|reactome:R-HSA-2408557|reactome:R-HSA-379716|dip:DIP-38215N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4+Ai/MIybmiKJyfa0C0bhnW/CG49606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48047	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26368	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742339|uniprotkb:Q96HC5|intact:EBI-946034|ensembl:ENSP00000307863	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u2af2_human(display_long)|uniprotkb:U2AF2(gene name)|psi-mi:U2AF2(display_short)|uniprotkb:U2AF65(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor large subunit(gene name synonym)|uniprotkb:U2 auxiliary factor 65 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|refseq:NP_001012496.1|refseq:NP_009210.1|ensembl:ENSG00000063244(gene)|ensembl:ENST00000308924(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|rcsb pdb:2HZC|rcsb pdb:2M0G|rcsb pdb:2U2F|rcsb pdb:2YH0|rcsb pdb:2YH1|rcsb pdb:3VAF|rcsb pdb:3VAG|rcsb pdb:3VAH|rcsb pdb:3VAI|rcsb pdb:3VAJ|rcsb pdb:3VAK|rcsb pdb:3VAL|rcsb pdb:3VAM|rcsb pdb:4FXW|rcsb pdb:4TU7|rcsb pdb:4TU8|rcsb pdb:4TU9|rcsb pdb:5EV1|rcsb pdb:5EV2|rcsb pdb:5EV3|rcsb pdb:5EV4|rcsb pdb:5W0G|rcsb pdb:5W0H|rcsb pdb:6TR0|rcsb pdb:6XLV|rcsb pdb:6XLW|rcsb pdb:6XLX|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:2G4B|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006529(U2 snRNP auxilliary factor, large subunit, splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P26368|rcsb pdb:1JMT|rcsb pdb:1O0P|rcsb pdb:1OPI|rcsb pdb:1U2F|go:"GO:0005654"(nucleoplasm)|dip:DIP-2154N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HBYwOej94CoGGN7vPbk0AnbO61Q9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02786	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00232	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q05D08	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190283	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q05d08_human(display_long)|uniprotkb:PA2G4(gene name)|psi-mi:PA2G4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR036388|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR018349|interpro:IPR036005|interpro:IPR036390	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JuKG8gmkmCiPRNyb6FtLmZUBbCI9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35579	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09211	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353467|uniprotkb:O00460|uniprotkb:Q15690|ensembl:ENSP00000381607|uniprotkb:Q5TZY3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstp1_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short)|uniprotkb:GST3(gene name synonym)|uniprotkb:FAEES3(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:GSTP1-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000843.1|ensembl:ENSG00000084207(gene)|go:"GO:0000302"(response to reactive oxygen species)|ensembl:ENST00000398606(transcript)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0035732"(nitric oxide storage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P09211|rcsb pdb:10GS|rcsb pdb:11GS|rcsb pdb:12GS|rcsb pdb:13GS|rcsb pdb:14GS|rcsb pdb:16GS|rcsb pdb:17GS|rcsb pdb:18GS|rcsb pdb:19GS|rcsb pdb:1AQV|rcsb pdb:1AQW|rcsb pdb:1AQX|rcsb pdb:1EOG|rcsb pdb:1EOH|rcsb pdb:1GSS|rcsb pdb:1KBN|rcsb pdb:1LBK|rcsb pdb:1MD3|rcsb pdb:1MD4|rcsb pdb:1PGT|rcsb pdb:1PX6|rcsb pdb:1PX7|rcsb pdb:1ZGN|rcsb pdb:20GS|rcsb pdb:22GS|rcsb pdb:2A2R|rcsb pdb:2A2S|rcsb pdb:2GSS|rcsb pdb:2J9H|rcsb pdb:2PGT|rcsb pdb:3CSH|rcsb pdb:3CSI|rcsb pdb:3CSJ|rcsb pdb:3DD3|rcsb pdb:3DGQ|rcsb pdb:3GSS|rcsb pdb:3GUS|rcsb pdb:3HJM|rcsb pdb:3HJO|rcsb pdb:3HKR|rcsb pdb:3IE3|rcsb pdb:3KM6|rcsb pdb:3KMN|rcsb pdb:3KMO|rcsb pdb:3N9J|rcsb pdb:3PGT|rcsb pdb:4GSS|rcsb pdb:4PGT|rcsb pdb:5DAK|rcsb pdb:5DAL|rcsb pdb:5DCG|rcsb pdb:5DDL|rcsb pdb:5DJL|rcsb pdb:5DJM|rcsb pdb:5GSS|rcsb pdb:5J41|rcsb pdb:5JCW|rcsb pdb:5L6X|rcsb pdb:5X79|rcsb pdb:6AP9|rcsb pdb:6GSS|rcsb pdb:6LLX|rcsb pdb:6Y1E|rcsb pdb:7GSS|rcsb pdb:8GSS|rcsb pdb:9GSS|reactome:R-HSA-156590|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxqbNusNIvkTg3Cq+7pmygP/EIA9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18124	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350806|uniprotkb:Q3KQU0|uniprotkb:Q15289|uniprotkb:Q5I0X1|uniprotkb:Q6IBM9|uniprotkb:A8K504|ensembl:ENSP00000339795	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl7_human(display_long)|uniprotkb:RPL7(gene name)|psi-mi:RPL7(display_short)|uniprotkb:Large ribosomal subunit protein uL30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000962.2|ensembl:ENSG00000147604(gene)|ensembl:ENST00000352983(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR018038|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699|mint:P18124|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72689	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:miVEaLOilDYcZXshxJlYbpnzwZ89606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15286	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722275|uniprotkb:B4E390|uniprotkb:B2R6E0|ensembl:ENSP00000229340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab35_human(display_long)|uniprotkb:Ras-related protein Rab-1C(gene name synonym)|uniprotkb:GTP-binding protein RAY(gene name synonym)|uniprotkb:RAB35(gene name)|psi-mi:RAB35(display_short)|uniprotkb:RAB1C(gene name synonym)|uniprotkb:RAY(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001161078.1|refseq:NP_006852.1|ensembl:ENSG00000111737(gene)|ensembl:ENST00000229340(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042470"(melanosome)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041815|mint:Q15286|rcsb pdb:3TW8|rcsb pdb:6EKK|rcsb pdb:6IF2|rcsb pdb:6IF3|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:95pH+DyDjv9FcxFeMmGYoJ0KyPo9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192398	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI0000073D6C|ipi:IPI00383111	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c10-like(display_short)|psi-mi:EBI-6192398(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.|comment:Probably contaminant.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zhw8GDGRkP65Pnm5ZMbBSMlTsqc9606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192381	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00786982|uniparc:UPI0000DD81BA	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:a9ln06-like(display_short)|psi-mi:EBI-6192381(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6190694|imex:IM-17358-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2019/05/28	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:It6ePqwtc+lreAAkOHfFSBhsW489606	intact-crc:E07F86BD3FD1CF80|rigid:0Co1VLU3kOESiyRwENhqILiwS6Y	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27694	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-621389|ensembl:ENSP00000254719|uniprotkb:Q59ES9|uniprotkb:A8K0Y9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rfa1_human(display_long)|uniprotkb:Replication factor A protein 1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:RPA1(gene name)|psi-mi:RPA1(display_short)|uniprotkb:REPA1(gene name synonym)|uniprotkb:RPA70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000132383(gene)|ensembl:ENST00000254719(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016605"(PML body)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|go:"GO:0006268"(DNA unwinding involved in DNA replication)|mint:P27694|rcsb pdb:1EWI|rcsb pdb:1FGU|rcsb pdb:1JMC|rcsb pdb:1L1O|rcsb pdb:2B29|rcsb pdb:2B3G|rcsb pdb:4IJH|rcsb pdb:4IJL|rcsb pdb:4IPC|rcsb pdb:4IPD|rcsb pdb:4IPG|rcsb pdb:4IPH|rcsb pdb:4LUO|rcsb pdb:4LUV|rcsb pdb:4LUZ|rcsb pdb:4LW1|rcsb pdb:4LWC|rcsb pdb:4NB3|rcsb pdb:4O0A|rcsb pdb:4R4C|rcsb pdb:4R4I|rcsb pdb:4R4O|rcsb pdb:4R4Q|rcsb pdb:4R4T|rcsb pdb:5E7N|rcsb pdb:5EAY|rcsb pdb:5N85|rcsb pdb:5N8A|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-3108214|refseq:NP_002936.1|dip:DIP-24189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DRZpMUlGyS0Qa5XFEtx71k0iPig9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35249	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-476655|uniprotkb:Q6FHX7|ensembl:ENSP00000296273|ensembl:ENSP00000376272|uniprotkb:D3DNV2|uniprotkb:B4DM41	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rfc4_human(display_long)|uniprotkb:Activator 1 subunit 4(gene name synonym)|uniprotkb:Replication factor C 37 kDa subunit(gene name synonym)|uniprotkb:Activator 1 37 kDa subunit(gene name synonym)|uniprotkb:RFC4(gene name)|psi-mi:RFC4(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002907.1|refseq:NP_853551.1|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000163918(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|ensembl:ENST00000296273(transcript)|ensembl:ENST00000392481(transcript)|mint:P35249|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|reactome:R-HSA-176187|dip:DIP-24267N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zn+V998ZRpYIdHmG87ExC6LFc0w9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14011	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-538850|uniprotkb:B4E2X2|intact:EBI-10980353|uniprotkb:B3KT17|ensembl:ENSP00000322887|ensembl:ENSP00000465779|ensembl:ENSP00000466110|ensembl:ENSP00000466207|ensembl:ENSP00000468788	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cirbp_human(display_long)|uniprotkb:Glycine-rich RNA-binding protein CIRP(gene name synonym)|uniprotkb:A18 hnRNP(gene name synonym)|uniprotkb:CIRBP(gene name)|psi-mi:CIRBP(display_short)|uniprotkb:A18HNRNP(gene name synonym)|uniprotkb:CIRP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001271.1|refseq:XP_006722700.1|refseq:NP_001287744.1|refseq:NP_001287758.1|ensembl:ENSG00000099622(gene)|ensembl:ENST00000320936(transcript)|ensembl:ENST00000585630(transcript)|ensembl:ENST00000586472(transcript)|ensembl:ENST00000588030(transcript)|ensembl:ENST00000588090(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0009409"(response to cold)|go:"GO:0009411"(response to UV)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030371"(translation repressor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:Q14011|rcsb pdb:1X5S|rcsb pdb:5TBX	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nm6/8k5Pw1AnoXsSw9cazJkL49U9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00040897|uniparc:UPI000013DB3E	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd2-like(display_short)|psi-mi:EBI-6192393(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0gMx01VsbQ6zzaL726ZE+OfqtX49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000059D477|ipi:IPI00641706|ipi:IPI00643158	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6-like(display_short)|psi-mi:EBI-6192365(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wy4rGlQIvXakPLyF0bFYzhvZW/49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192387	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000016193E|ipi:IPI00456898	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs12-like(display_short)|psi-mi:EBI-6192387(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.|comment:"Maps to obsolete UniProt_AC (A6NCP0)"	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ef6hwOole2ed/kmvG2tkefUpV+A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192353	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00792850|uniparc:UPI0000E5ADE6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:zyx-like(display_short)|psi-mi:EBI-6192353(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SIOzC91N2HMw+7voQITeRCePuC89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00736402|uniparc:UPI00006C1D56	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nog1-like(display_short)|psi-mi:EBI-6192338(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:06I44nYqpH+AFVArCyEzNHAM7zM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192360	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI0000D6259C|ipi:IPI00744503	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg2-like(display_short)|psi-mi:EBI-6192360(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:L9FDFHlcKLLIb2AuVWClY2e7vhs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI000059D477|ipi:IPI00641706|ipi:IPI00643158	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb6-like(display_short)|psi-mi:EBI-6192365(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wy4rGlQIvXakPLyF0bFYzhvZW/49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28331-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190702|ensembl:ENSP00000392709|ensembl:ENSP00000490092	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p28331-2(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000455934(transcript)|ensembl:ENST00000637733(transcript)|intact:EBI-1043922(isoform-parent)|uniprotkb:P28331-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kKrRPFU4CRdHw5sNtWXMEoWgMEI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21796	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00459	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62310	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348239|ensembl:ENSP00000302160|uniprotkb:Q9Y4Z1|uniprotkb:Q6IAH0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lsm3_human(display_long)|uniprotkb:MDS017(orf name)|uniprotkb:LSM3(gene name)|psi-mi:LSM3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000170860(gene)|ensembl:ENST00000306024(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0030629"(U6 snRNA 3'-end binding)|go:"GO:0033962"(P-body assembly)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034105|interpro:IPR040002|mint:P62310|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|refseq:NP_055278.1|dip:DIP-31218N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+OnRI9eJcsd1xJe+cUCP7Y/9tt09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P16949	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-445909|uniprotkb:A2A2D1|uniprotkb:B7Z8N4|uniprotkb:D3DPJ5|uniprotkb:B2R4E7|ensembl:ENSP00000350531|ensembl:ENSP00000363409|ensembl:ENSP00000382633|ensembl:ENSP00000387858	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stmn1_human(display_long)|uniprotkb:Phosphoprotein p19(gene name synonym)|uniprotkb:Leukemia-associated phosphoprotein p18(gene name synonym)|uniprotkb:Oncoprotein 18(gene name synonym)|uniprotkb:pp17(gene name synonym)|uniprotkb:Prosolin(gene name synonym)|uniprotkb:Metablastin(gene name synonym)|uniprotkb:Protein Pr22(gene name synonym)|uniprotkb:STMN1(gene name)|psi-mi:STMN1(display_short)|uniprotkb:LAP18(gene name synonym)|uniprotkb:OP18(gene name synonym)|uniprotkb:C1orf215(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138926.1|refseq:NP_005554.1|refseq:NP_981944.1|refseq:NP_981946.1|ensembl:ENST00000357865(transcript)|ensembl:ENST00000374291(transcript)|ensembl:ENST00000399728(transcript)|ensembl:ENST00000455785(transcript)|go:"GO:0000281"(mitotic cytokinesis)|ensembl:ENSG00000117632(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|mint:P16949|interpro:IPR000956(Stathmin)|interpro:IPR030514|interpro:IPR036002|reactome:R-HSA-1251985	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gew+NqUuLLolCLCXOyXIZkRieIs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26599	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350540|ensembl:ENSP00000014112|intact:EBI-744534|uniprotkb:Q9BUQ0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptbp1_human(display_long)|uniprotkb:PTBP1(gene name)|psi-mi:PTBP1(display_short)|uniprotkb:PTB(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein I(gene name synonym)|uniprotkb:57 kDa RNA-binding protein PPTB-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002810.1|refseq:NP_114367.1|refseq:NP_114368.1|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0016020"(membrane)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034798|interpro:IPR035000|interpro:IPR035001|interpro:IPR035979|mint:P26599|rcsb pdb:1QM9|rcsb pdb:1SJQ|ensembl:ENSG00000011304(gene)|ensembl:ENST00000349038(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0008380"(RNA splicing)|rcsb pdb:2AD9|rcsb pdb:2ADB|rcsb pdb:2ADC|rcsb pdb:2EVZ|rcsb pdb:2N3O|rcsb pdb:3ZZY|rcsb pdb:3ZZZ|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|rcsb pdb:1SJR	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fkSnYJELgHxDP0oAQEjBmSX0HIs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43447	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62913	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354380|uniprotkb:P25121|uniprotkb:P39026|uniprotkb:Q8TDH2|uniprotkb:Q9Y674|ensembl:ENSP00000496250	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl11_human(display_long)|uniprotkb:RPL11(gene name)|psi-mi:RPL11(display_short)|uniprotkb:CLL-associated antigen KW-12(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000966.2|refseq:NP_001186731.1|ensembl:ENSG00000142676(gene)|ensembl:ENST00000643754(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006605"(protein targeting)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR002132(Ribosomal protein L5)|interpro:IPR020929|interpro:IPR022803|interpro:IPR031309|interpro:IPR031310|mint:P62913|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4XXB|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y6X	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xt8XhDkfQPoH4DIPr0gC+ll766Q9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75340	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352915|uniprotkb:E7ESR3|uniprotkb:Q5TZS0|uniprotkb:B2RD16|uniprotkb:Q2YDC2|ensembl:ENSP00000264933	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdcd6_human(display_long)|uniprotkb:PDCD6(gene name)|psi-mi:PDCD6(display_short)|uniprotkb:ALG2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O75340|rcsb pdb:2ZN8|rcsb pdb:2ZN9|rcsb pdb:2ZND|rcsb pdb:2ZNE|rcsb pdb:2ZRS|rcsb pdb:2ZRT|rcsb pdb:3AAJ|rcsb pdb:3AAK|rcsb pdb:3WXA|rcsb pdb:5GQQ|go:"GO:0046983"(protein dimerization activity)|refseq:NP_037364.1|refseq:NP_001254485.1|refseq:NP_001254486.1|refseq:NP_001254487.1|refseq:NP_001254488.1|ensembl:ENSG00000249915(gene)|ensembl:ENST00000264933(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|dip:DIP-33217N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qbNAx73X9TJNr0MVNcy7Q9qN3Hg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40227	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356687|uniprotkb:Q3KP28|uniprotkb:Q75LP4|uniprotkb:Q96S46|ensembl:ENSP00000275603|intact:EBI-5912031|uniprotkb:A6NCD2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpz_human(display_long)|uniprotkb:CCT6A(gene name)|psi-mi:CCT6A(display_short)|uniprotkb:CCT6(gene name synonym)|uniprotkb:CCTZ(gene name synonym)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Tcp20(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Acute morphine dependence-related protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001753.1|ensembl:ENSG00000146731(gene)|ensembl:ENST00000275603(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P40227|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|refseq:NP_001009186.1|dip:DIP-33558N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kX6/rTGZbGuVLNgBW6IxdNlU46U9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62136	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30153	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05109	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355281|uniprotkb:Q5SY70|uniprotkb:Q9UC92|uniprotkb:Q9UCJ0|uniprotkb:A8K5L3|uniprotkb:Q9UC84|uniprotkb:Q9UCM6|uniprotkb:D3DV37|ensembl:ENSP00000357721|ensembl:ENSP00000357722	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:s10a8_human(display_long)|uniprotkb:S100A8(gene name)|psi-mi:S100A8(display_short)|uniprotkb:CAGA(gene name synonym)|uniprotkb:MRP8(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:S100 calcium-binding protein A8(gene name synonym)|uniprotkb:Calgranulin-A(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 8(gene name synonym)|uniprotkb:Cystic fibrosis antigen(gene name synonym)|uniprotkb:Leukocyte L1 complex light chain(gene name synonym)|uniprotkb:Calprotectin L1L subunit(gene name synonym)|uniprotkb:Urinary stone protein band A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001306126.1|refseq:NP_001306127.1|refseq:NP_001306130.1|refseq:NP_002955.2|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045471"(response to ethanol)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028474|go:"GO:0035662"(Toll-like receptor 4 binding)|mint:P05109|rcsb pdb:1MR8|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5HLO|rcsb pdb:5HLV|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENST00000368732(transcript)|ensembl:ENST00000368733(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|ensembl:ENSG00000143546(gene)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|dip:DIP-1165N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Okfhj8fxclZ0Uo/Fa1Z89qC8Ec9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00403	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-389564|uniprotkb:A8K1A7|uniprotkb:Q5JS30|ensembl:ENSP00000359531	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tf2b_human(display_long)|uniprotkb:GTF2B(gene name)|psi-mi:GTF2B(display_short)|uniprotkb:TF2B(gene name synonym)|uniprotkb:TFIIB(gene name synonym)|uniprotkb:General transcription factor TFIIB(gene name synonym)|uniprotkb:S300-II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001505.1|ensembl:ENSG00000137947(gene)|ensembl:ENST00000370500(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001174"(transcriptional start site selection at RNA polymerase II promoter)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005694"(chromosome)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019083"(viral transcription)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990114"(RNA polymerase II core complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000812(Transcription factor TFIIB related)|interpro:IPR013137(Zinc finger, TFIIB-type)|interpro:IPR013150(Transcription factor TFIIB, cyclin-related)|interpro:IPR013763(Cyclin-related)|interpro:IPR023486|interpro:IPR036915|mint:Q00403|rcsb pdb:1C9B|rcsb pdb:1DL6|rcsb pdb:1RLY|rcsb pdb:1RO4|rcsb pdb:1TFB|rcsb pdb:1VOL|rcsb pdb:2PHG|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5WH1|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|dip:DIP-1077N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mVGHi0jBibSFHpBrVTGHnRm4gXw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14744	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351098|uniprotkb:Q6IBR1|uniprotkb:A8MZ91|uniprotkb:Q9UKH1|uniprotkb:B5BU10|uniprotkb:D3DS33|ensembl:ENSP00000319169|uniprotkb:A8MTP3|uniprotkb:B4DX49|uniprotkb:B4DY30|uniprotkb:E2QRE7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anm5_human(display_long)|uniprotkb:PRMT5(gene name)|psi-mi:PRMT5(display_short)|uniprotkb:IBP72(gene name synonym)|uniprotkb:JBP1(gene name synonym)|uniprotkb:HRMT1L5(gene name synonym)|uniprotkb:Shk1 kinase-binding protein 1 homolog(gene name synonym)|uniprotkb:Jak-binding protein 1(gene name synonym)|uniprotkb:72 kDa ICln-binding protein(gene name synonym)|uniprotkb:SKB1(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001034708.1|refseq:NP_006100.2|refseq:NP_001269882.1|refseq:NP_001269884.1|refseq:NP_001269885.1|ensembl:ENSG00000100462(gene)|ensembl:ENST00000324366(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000785"(chromatin)|go:"GO:0002039"(p53 binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034709"(methylosome)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035243"(protein-arginine omega-N symmetric methyltransferase activity)|go:"GO:0035246"(peptidyl-arginine N-methylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0097421"(liver regeneration)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR007857(Skb1 methyltransferase)|interpro:IPR025799|interpro:IPR029063|interpro:IPR035075|interpro:IPR035247|interpro:IPR035248|mint:O14744|rcsb pdb:4GQB|rcsb pdb:4X60|rcsb pdb:4X61|rcsb pdb:4X63|rcsb pdb:5C9Z|rcsb pdb:5EMJ|rcsb pdb:5EMK|rcsb pdb:5EML|rcsb pdb:5EMM|rcsb pdb:5FA5|rcsb pdb:6CKC|rcsb pdb:6K1S|rcsb pdb:6RLL|rcsb pdb:6RLQ|rcsb pdb:6UGH|rcsb pdb:6UXX|rcsb pdb:6UXY|rcsb pdb:6V0N|rcsb pdb:6V0O|rcsb pdb:6V0P|rcsb pdb:7KIB|rcsb pdb:7KIC|rcsb pdb:7KID|rcsb pdb:7L1G|rcsb pdb:7M05|reactome:R-HSA-191859|reactome:R-HSA-3214858|reactome:R-HSA-6804760|go:"GO:1904992"(positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway)|dip:DIP-33172N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:EwePjCDiU/fiuKOO+wnoYQ8I57I9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H3S7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724478|uniprotkb:Q7KZF8|uniprotkb:Q8N6Z5|uniprotkb:Q9BSR5|uniprotkb:Q9P257|uniprotkb:Q9UG03|uniprotkb:Q9UMZ4|uniprotkb:A8K0D7|ensembl:ENSP00000265562	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptn23_human(display_long)|uniprotkb:His domain-containing protein tyrosine phosphatase(gene name synonym)|uniprotkb:Protein tyrosine phosphatase TD14(gene name synonym)|uniprotkb:PTPN23(gene name)|psi-mi:PTPN23(display_short)|uniprotkb:KIAA1471(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056281.1|ensembl:ENSG00000076201(gene)|ensembl:ENST00000265562(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0060271"(cilium assembly)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903387"(positive regulation of homophilic cell adhesion)|go:"GO:1903393"(positive regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004328(BRO1)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR025304|interpro:IPR029021|interpro:IPR038499|mint:Q9H3S7|rcsb pdb:5CRU|rcsb pdb:5CRV|rcsb pdb:5LM1|rcsb pdb:5LM2|rcsb pdb:5MJY|rcsb pdb:5MJZ|rcsb pdb:5MK0|rcsb pdb:5MK1|rcsb pdb:5MK2|rcsb pdb:5MK3|reactome:R-HSA-9008059|rcsb pdb:3RAU|refseq:NP_001291411.1|dip:DIP-29923N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PeqzQLL4J4v9IMuHFBlb+1B4Ujw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75489	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408	-	-	crc64:C058D62779BEF17B	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62633	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00560	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727004|uniprotkb:O43391|ensembl:ENSP00000260130|ensembl:ENSP00000411771|uniprotkb:O00173|uniprotkb:Q14CP2|uniprotkb:B4DUH3|uniprotkb:B7ZLN2|uniprotkb:B2R5Q7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdcb1_human(display_long)|uniprotkb:Scaffold protein Pbp1(gene name synonym)|uniprotkb:Pro-TGF-alpha cytoplasmic domain-interacting protein 18(gene name synonym)|uniprotkb:Syndecan-binding protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 9(gene name synonym)|uniprotkb:SDCBP(gene name)|psi-mi:SDCBP(display_short)|uniprotkb:MDA9(gene name synonym)|uniprotkb:SYCL(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000137575(gene)|ensembl:ENST00000260130(transcript)|ensembl:ENST00000413219(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005109"(frizzled binding)|go:"GO:0005137"(interleukin-5 receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|refseq:NP_001007068.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005895"(interleukin-5 receptor complex)|go:"GO:0005912"(adherens junction)|refseq:NP_001007069.1|refseq:NP_001007070.1|refseq:NP_001007071.1|refseq:NP_005616.2|go:"GO:0005925"(focal adhesion)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030528|interpro:IPR036034|go:"GO:0042802"(identical protein binding)|rcsb pdb:1N99|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:1NTE|go:"GO:0045121"(membrane raft)|rcsb pdb:1OBX|rcsb pdb:1OBY|rcsb pdb:1OBZ|go:"GO:0045202"(synapse)|go:"GO:0045545"(syndecan binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:1R6J|rcsb pdb:1V1T|rcsb pdb:1W9E|rcsb pdb:1W9O|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0099054"(presynapse assembly)|go:"GO:1903543"(positive regulation of exosomal secretion)|rcsb pdb:1W9Q|rcsb pdb:1YBO|rcsb pdb:4Z33|rcsb pdb:6R9H|rcsb pdb:6RLC|reactome:R-HSA-3928664|reactome:R-HSA-447043|reactome:R-HSA-5213460|reactome:R-HSA-6798695|reactome:R-HSA-5675482|dip:DIP-42705N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ys2RNVwH0n5AKA+rBULM9Foxccg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62140	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31948	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95777	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347779|ensembl:ENSP00000249299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P67809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NSD9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353803|uniprotkb:B4DFM0|uniprotkb:O95708|uniprotkb:Q9NZZ6|uniprotkb:Q4ZFX1|uniprotkb:Q57ZJ5|ensembl:ENSP00000281828	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syfb_human(display_long)|uniprotkb:FARSB(gene name)|psi-mi:FARSB(display_short)|uniprotkb:FARSLB(gene name synonym)|uniprotkb:FRSB(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase beta subunit(gene name synonym)|uniprotkb:HSPC173(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005678.3|refseq:XP_006712232.1|refseq:XP_011508768.1|ensembl:ENSG00000116120(gene)|ensembl:ENST00000281828(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR004531(Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR005147(tRNA synthetase, B5)|interpro:IPR009061(Putative DNA binding)|interpro:IPR020825|interpro:IPR040659|interpro:IPR041616|rcsb pdb:3L4G|reactome:R-HSA-379716|refseq:XP_016858599.1|dip:DIP-32869N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YgMUMEiw+jAUaDK5KomMWi66vn09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473271|uniprotkb:Q2NKN2|uniprotkb:Q59EA1|ensembl:ENSP00000296702	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcrg1_human(display_long)|uniprotkb:TATA box-binding protein-associated factor 2S(gene name synonym)|uniprotkb:Transcription factor CA150(gene name synonym)|uniprotkb:TCERG1(gene name)|psi-mi:TCERG1(display_short)|uniprotkb:CA150(gene name synonym)|uniprotkb:TAF2S(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035095.1|refseq:NP_006697.2|dip:DIP-32504N|ensembl:ENSG00000113649(gene)|ensembl:ENST00000296702(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003711"(transcription elongation regulator activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0042802"(identical protein binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002713(FF)|interpro:IPR036020|interpro:IPR036517|mint:O14776|rcsb pdb:2DK7|rcsb pdb:2DOD|rcsb pdb:2DOE|rcsb pdb:2DOF|rcsb pdb:2E71|rcsb pdb:2KIQ|rcsb pdb:2KIS|rcsb pdb:2MW9|rcsb pdb:2MWA|rcsb pdb:2MWB|rcsb pdb:2MWD|rcsb pdb:2MWE|rcsb pdb:2MWF|rcsb pdb:2N4R|rcsb pdb:2N4S|rcsb pdb:2N4T|rcsb pdb:2N4U|rcsb pdb:2N4V|rcsb pdb:2N4W|rcsb pdb:2NNT|rcsb pdb:3HFH|rcsb pdb:3Q1I|rcsb pdb:4FQG|rcsb pdb:7ABF|rcsb pdb:7ABG	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KDFTOtTUWHzQ9yzRj7BbhFTQXiM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62937	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08670	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15366	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945799|uniprotkb:Q6PKG5|intact:EBI-9640573|uniprotkb:Q6IPF4|uniprotkb:B4DXP5|intact:EBI-2555278|uniprotkb:A8K7X6|uniprotkb:F8VYL7|uniprotkb:Q32Q82|uniprotkb:Q68Y55|uniprotkb:I6L8F9|uniprotkb:Q59HD4|uniprotkb:G3V0E8|ensembl:ENSP00000408949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcbp2_human(display_long)|uniprotkb:PCBP2(gene name)|psi-mi:PCBP2(display_short)|uniprotkb:Alpha-CP2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001122383.1|refseq:NP_114366.1|refseq:NP_005007.2|refseq:NP_001092090.1|refseq:NP_001122384.1|refseq:NP_001122385.1|refseq:NP_001122386.1|dip:DIP-58934N|ensembl:ENSG00000197111(gene)|ensembl:ENST00000439930(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15366|rcsb pdb:2AXY|rcsb pdb:2JZX|rcsb pdb:2P2R|rcsb pdb:2PQU|rcsb pdb:2PY9|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-936440	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KWabGhH+pfSX5k0vzs3SXH8Agaw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N5M4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2851213|uniprotkb:Q8WYY7|ensembl:ENSP00000325266|ensembl:ENSP00000434340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ttc9c_human(display_long)|uniprotkb:TTC9C(gene name)|psi-mi:TTC9C(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001305745.1|refseq:NP_776171.1|refseq:NP_001305741.1|refseq:NP_001305742.1|refseq:NP_001305743.1|refseq:NP_001305744.1|ensembl:ENSG00000162222(gene)|ensembl:ENST00000316461(transcript)|ensembl:ENST00000532583(transcript)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IazckGbo0Z5cqr/m7hx7Av7BJlU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22087	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358318|uniprotkb:O75259|uniprotkb:Q6IAT5|uniprotkb:Q9UPI6|ensembl:ENSP00000221801|ensembl:ENSP00000487390|uniprotkb:B5BUE8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fbrl_human(display_long)|uniprotkb:FBL(gene name)|psi-mi:FBL(display_short)|uniprotkb:FIB1(gene name synonym)|uniprotkb:FLRN(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)|uniprotkb:34 kDa nucleolar scleroderma antigen(gene name synonym)|uniprotkb:U6 snRNA 2'-O-methyltransferase fibrillarin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001427.2|ensembl:ENSG00000105202(gene)|ensembl:ENSG00000280548(gene)|ensembl:ENST00000221801(transcript)|ensembl:ENST00000625241(transcript)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0001652"(granular component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|mint:P22087|rcsb pdb:2IPX|reactome:R-HSA-6790901|reactome:R-HSA-6791226|dip:DIP-27569N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8m8FDRSxGNKNXpJMcWWbcHL3uss9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BUL8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O94979	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1767898|uniprotkb:Q17RR5|uniprotkb:Q5H9P6|uniprotkb:Q5XG74|uniprotkb:Q659G7|uniprotkb:Q6ZU90|uniprotkb:Q7LCX9|uniprotkb:Q86TJ0|uniprotkb:Q8IZH4|uniprotkb:Q9P048|uniprotkb:Q9P0A6|uniprotkb:Q9UM05|uniprotkb:Q9UM06|uniprotkb:B7ZKZ7|uniprotkb:B7ZL00|uniprotkb:B4DIW6|uniprotkb:H7C2W3|ensembl:ENSP00000347329|ensembl:ENSP00000378721|ensembl:ENSP00000400926	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc31a_human(display_long)|uniprotkb:SEC31A(gene name)|psi-mi:SEC31A(display_short)|uniprotkb:KIAA0905(gene name synonym)|uniprotkb:SEC31L1(gene name synonym)|uniprotkb:HSPC275(orf name)|uniprotkb:HSPC334(orf name)|uniprotkb:SEC31-related protein A(gene name synonym)|uniprotkb:SEC31-like protein 1(gene name synonym)|uniprotkb:ABP125(gene name synonym)|uniprotkb:ABP130(gene name synonym)|uniprotkb:Web1-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070674.1|refseq:NP_001070675.1|refseq:NP_001070676.1|refseq:NP_057295.2|refseq:NP_001305048.1|refseq:NP_001305049.1|refseq:NP_001287673.1|refseq:NP_001287674.1|refseq:NP_001177978.1|dip:DIP-40438N|ensembl:ENSG00000138674(gene)|ensembl:ENST00000355196(transcript)|ensembl:ENST00000395310(transcript)|ensembl:ENST00000448323(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024298|interpro:IPR036322|interpro:IPR040251|mint:O94979|rcsb pdb:3WXA|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-381038|reactome:R-HSA-983170	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MvtQi/4RmQ0siNtNoYH6k1rPv1Y9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P37802	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056740|intact:EBI-2825986|uniprotkb:Q5JRQ6|uniprotkb:Q5JRQ7|uniprotkb:Q9BUH5|uniprotkb:Q9H4P0|uniprotkb:Q6FGI1|uniprotkb:E9KL39|ensembl:ENSP00000357075|ensembl:ENSP00000357077	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tagl2_human(display_long)|uniprotkb:TAGLN2(gene name)|psi-mi:TAGLN2(display_short)|uniprotkb:KIAA0120(gene name synonym)|uniprotkb:SM22-alpha homolog(gene name synonym)|uniprotkb:CDABP0035(orf name)|uniprotkb:Epididymis tissue protein Li 7e(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003555.1|refseq:NP_001264152.1|refseq:NP_001264153.1|ensembl:ENSG00000158710(gene)|ensembl:ENST00000320307(transcript)|ensembl:ENST00000368097(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000557(Calponin repeat)|interpro:IPR001061("Transgelin (SM22-alpha)")|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|mint:P37802|rcsb pdb:1WYM|reactome:R-HSA-114608	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxbMK5SbZWQd+XA9iYc/xuNaVQc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53992	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-81134|uniprotkb:Q8WV25|ensembl:ENSP00000321845|ensembl:ENSP00000343405|uniprotkb:B4DZT4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc24c_human(display_long)|uniprotkb:SEC24C(gene name)|psi-mi:SEC24C(display_short)|uniprotkb:KIAA0079(gene name synonym)|uniprotkb:SEC24-related protein C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR041742|mint:P53992|rcsb pdb:3EH2|rcsb pdb:6PU1|reactome:R-HSA-1655829|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-983170|reactome:R-HSA-5694530|ensembl:ENSG00000176986(gene)|ensembl:ENST00000339365(transcript)|ensembl:ENST00000345254(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030127"(COPII vesicle coat)|refseq:NP_004913.2|refseq:NP_940999.1|dip:DIP-30981N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kOKJkIWFOlIpRFLj5JshAGqAg6s9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49721	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359335|uniprotkb:P31145|uniprotkb:Q9BWZ9|uniprotkb:D3DPS0|ensembl:ENSP00000362334	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb2_human(display_long)|uniprotkb:PSMB2(gene name)|psi-mi:PSMB2(display_short)|uniprotkb:Multicatalytic endopeptidase complex subunit C7-I(gene name synonym)|uniprotkb:Proteasome component C7-I(gene name synonym)|uniprotkb:Macropain subunit C7-I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002785.1|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5GJR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-5689603|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000126067(gene)|ensembl:ENST00000373237(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035206|mint:P49721|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|dip:DIP-33848N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PvXrk6RLayQ1zqmavn1cONfA9/A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B0JYQ0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b0jyq0_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005615"(extracellular space)|go:"GO:0046872"(metal ion binding)|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZRiIE/g0lqxM4BoYZ1F4bLVNdos9913	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12270	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048528|uniprotkb:Q15655|uniprotkb:Q99968|uniprotkb:Q5SWY0|intact:EBI-2555905|uniprotkb:Q15624|intact:EBI-28974527|ensembl:ENSP00000356448	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tpr_human(display_long)|uniprotkb:TPR(gene name)|psi-mi:TPR(display_short)|uniprotkb:Megator(gene name synonym)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000356448|ensembl:ENST00000613151|ensembl:ENSP00000483425|refseq:NP_003283.2|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|rcsb pdb:5TO5|rcsb pdb:5TO6|rcsb pdb:5TO7|rcsb pdb:5TVB|reactome:R-HSA-1169408|reactome:R-HSA-159227|ensembl:ENSG00000047410(gene)|ensembl:ENST00000367478(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|dip:DIP-50405N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vgoHzJI4cSOfqPSDoy+E067AdoI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60264	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352588|ensembl:ENSP00000283131	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smca5_human(display_long)|uniprotkb:SMARCA5(gene name)|psi-mi:SMARCA5(display_short)|uniprotkb:SNF2H(gene name synonym)|uniprotkb:WCRF135(gene name synonym)|uniprotkb:Sucrose nonfermenting protein 2 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000283131(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016589"(NURF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031213"(RSF complex)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015194(Nucleosome remodelling ATPase ISWI, HAND)|interpro:IPR015195(SLIDE)|interpro:IPR017884|interpro:IPR027417|interpro:IPR036306|interpro:IPR038718|mint:O60264|rcsb pdb:6NE3|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5693565|reactome:R-HSA-606279|refseq:NP_003592.3|ensembl:ENSG00000153147(gene)|dip:DIP-33204N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XlXL5MRhAFlqHhGroPdm01lYEk89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30041	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2255129|uniprotkb:A8JZY7|uniprotkb:P32077|uniprotkb:Q5TAH4|uniprotkb:Q5ZEZ8|ensembl:ENSP00000342026	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx6_human(display_long)|uniprotkb:PRDX6(gene name)|psi-mi:PRDX6(display_short)|uniprotkb:AOP2(gene name synonym)|uniprotkb:KIAA0106(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:24 kDa protein(gene name synonym)|uniprotkb:Liver 2D page spot 40(gene name synonym)|uniprotkb:Red blood cells page spot 12(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004896.1|ensembl:ENSG00000117592(gene)|ensembl:ENST00000340385(transcript)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:1PRX|rcsb pdb:5B6M|rcsb pdb:5B6N|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0042744"(hydrogen peroxide catabolic process)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZMsHgrAJf0VJiCELzo+zSi8Ji+49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61081	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1041660|uniprotkb:O76069|uniprotkb:Q8VC50|ensembl:ENSP00000253023	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubc12_human(display_long)|uniprotkb:UBE2M(gene name)|psi-mi:UBE2M(display_short)|uniprotkb:UBC12(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 M(gene name synonym)|uniprotkb:NEDD8 carrier protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003960.1|ensembl:ENSG00000130725(gene)|ensembl:ENST00000253023(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61081|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:2NVU|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4GAO|rcsb pdb:4P5O|reactome:R-HSA-2173789|reactome:R-HSA-5607761|reactome:R-HSA-5676590|dip:DIP-35679N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A6NKE1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190709|ensembl:ENSP00000362253	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:a6nke1_human(display_long)|uniprotkb:TRAPPC3(gene name)|psi-mi:TRAPPC3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000054116(gene)|ensembl:ENST00000373159(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030008"(TRAPP complex)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR016721(TRAPP I complex, Bet3)|interpro:IPR024096|interpro:IPR007194("Transport protein particle (TRAPP) component, Bet3")	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:39R93986KCjktIWg8GOua2Ak/j89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49368	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62314	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372177|uniprotkb:P13641|uniprotkb:B5BTZ1|ensembl:ENSP00000300413	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd1_human(display_long)|uniprotkb:SNRPD1(gene name)|psi-mi:SNRPD1(display_short)|uniprotkb:snRNP core protein D1(gene name synonym)|uniprotkb:Sm-D autoantigen(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001278845.1|refseq:NP_008869.1|ensembl:ENSG00000167088(gene)|ensembl:ENST00000300413(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|go:"GO:0000243"(commitment complex)|interpro:IPR027141|interpro:IPR034102|mint:P62314|rcsb pdb:1B34|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|go:"GO:0000245"(spliceosomal complex assembly)|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5XJL|rcsb pdb:5XJQ|go:"GO:0000387"(spliceosomal snRNP assembly)|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|dip:DIP-31207N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfXwsV+IOjDPCoOJOoMQgECyiII9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13283	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BV40	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727028|uniprotkb:O60625|uniprotkb:Q53SP9|uniprotkb:Q6IB09|ensembl:ENSP00000263864	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vamp8_human(display_long)|uniprotkb:Endobrevin(gene name synonym)|uniprotkb:VAMP8(gene name)|psi-mi:VAMP8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003752.2|ensembl:ENSG00000118640(gene)|ensembl:ENST00000263864(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|mint:Q9BV40|rcsb pdb:4WY4|rcsb pdb:7BV6|reactome:R-HSA-1236974|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|dip:DIP-40358N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DW/t33n6NkBelQt6H1QS5hUY5+E9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17844	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P20618	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372273|uniprotkb:Q9BWA8|ensembl:ENSP00000262193|uniprotkb:B5BU76	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb1_human(display_long)|uniprotkb:PSMB1(gene name)|psi-mi:PSMB1(display_short)|uniprotkb:PSC5(gene name synonym)|uniprotkb:Proteasome component C5(gene name synonym)|uniprotkb:Macropain subunit C5(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C5(gene name synonym)|uniprotkb:Proteasome gamma chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000008018(gene)|ensembl:ENST00000262193(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035202|mint:P20618|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5L5B|rcsb pdb:5L5D|rcsb pdb:5L5E|rcsb pdb:5L5F|refseq:NP_002784.1|rcsb pdb:5L5H|rcsb pdb:5L5I|rcsb pdb:5L5J|rcsb pdb:5L5O|rcsb pdb:5L5P|rcsb pdb:5L5Q|rcsb pdb:5L5R|rcsb pdb:5L5S|rcsb pdb:5L5T|rcsb pdb:5L5U|rcsb pdb:5L5V|rcsb pdb:5L5W|rcsb pdb:5L5X|rcsb pdb:5L5Y|rcsb pdb:5L5Z|rcsb pdb:5L60|rcsb pdb:5L61|rcsb pdb:5L62|rcsb pdb:5L63|rcsb pdb:5L64|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M2B|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5LF1|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4608870|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-983168|reactome:R-HSA-9604323|dip:DIP-31193N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DfIS480BUnqbXus9/KoojdkWgw09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22061	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353343|uniprotkb:Q14661|uniprotkb:Q16556|uniprotkb:Q5VYC1|uniprotkb:Q5VYC2|uniprotkb:Q93061|uniprotkb:Q96II9|uniprotkb:Q99625|uniprotkb:Q9BQV7|uniprotkb:Q9BQV8|uniprotkb:Q9NP03|uniprotkb:A8K109|intact:EBI-2551555|uniprotkb:J3KP72|ensembl:ENSP00000356348|ensembl:ENSP00000420813	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pimt_human(display_long)|uniprotkb:PCMT1(gene name)|psi-mi:PCMT1(display_short)|uniprotkb:Protein-beta-aspartate methyltransferase(gene name synonym)|uniprotkb:Protein L-isoaspartyl/D-aspartyl methyltransferase(gene name synonym)|uniprotkb:L-isoaspartyl protein carboxyl methyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001238978.1|refseq:NP_001238982.1|ensembl:ENSG00000120265(gene)|ensembl:ENST00000367378(transcript)|ensembl:ENST00000464889(transcript)|go:"GO:0004719"("protein-L-isoaspartate (D-aspartate) O-methyltransferase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0030091"(protein repair)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000682("Protein-L-isoaspartate(D-aspartate) O-methyltransferase")|interpro:IPR029063|mint:P22061|rcsb pdb:1I1N|rcsb pdb:1KR5|reactome:R-HSA-5676934|refseq:NP_005380.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wfsjVloc3sqDMXlvFAXQI6Fjilw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55072	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31040	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10768	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052334|uniprotkb:Q5TBU8|uniprotkb:Q5TBV0|uniprotkb:Q5TBV2|uniprotkb:Q9BVJ2|ensembl:ENSP00000367992	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:estd_human(display_long)|uniprotkb:Esterase D(gene name synonym)|uniprotkb:ESD(gene name)|psi-mi:ESD(display_short)|uniprotkb:Methylumbelliferyl-acetate deacetylase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001975.1|refseq:XP_011533256.1|refseq:XP_005266335.1|ensembl:ENSG00000139684(gene)|ensembl:ENST00000378720(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0018738"(S-formylglutathione hydrolase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0046294"(formaldehyde catabolic process)|go:"GO:0047374"(methylumbelliferyl-acetate deacetylase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000801(Putative esterase)|interpro:IPR014186(S-formylglutathione hydrolase)|interpro:IPR029058|rcsb pdb:3FCX|reactome:R-HSA-156590	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I8V/PLKeeDbsSgkLk0BADWVbDdg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32119	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1266300|uniprotkb:P31945|uniprotkb:P32118|uniprotkb:P35701|uniprotkb:Q6FHG4|uniprotkb:Q92763|uniprotkb:Q9UC23|uniprotkb:A8K0C0|ensembl:ENSP00000301522	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx2_human(display_long)|uniprotkb:PRDX2(gene name)|psi-mi:PRDX2(display_short)|uniprotkb:NKEFB(gene name synonym)|uniprotkb:TDPX1(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor B(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005800.3|dip:DIP-39882N|ensembl:ENSG00000167815(gene)|ensembl:ENST00000301522(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P32119|rcsb pdb:1QMV|rcsb pdb:5B8A|rcsb pdb:5B8B|rcsb pdb:5IJT|rcsb pdb:7KIZ|rcsb pdb:7KJ0|rcsb pdb:7KJ1|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:F8+7/3HrAcJq7BjkZaig16mCOO89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21912	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13765	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712216|ensembl:ENSP00000349212|ensembl:ENSP00000377469|ensembl:ENSP00000446801|ensembl:ENSP00000447821|ensembl:ENSP00000503345|uniprotkb:Q3KQV4|uniprotkb:Q53A18|uniprotkb:Q53G46|uniprotkb:A8MTN7|uniprotkb:B2R4P8|uniprotkb:F8VU71	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:naca_human(display_long)|uniprotkb:Alpha-NAC(gene name synonym)|uniprotkb:NACA(gene name)|psi-mi:NACA(display_short)|uniprotkb:HSD48(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000196531(gene)|ensembl:ENST00000356769(transcript)|ensembl:ENST00000393891(transcript)|ensembl:ENST00000546392(transcript)|ensembl:ENST00000552540(transcript)|ensembl:ENST00000678066(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006412"(translation)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0015031"(protein transport)|go:"GO:0042060"(wound healing)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901227"(negative regulation of transcription from RNA polymerase II promoter involved in heart development)|go:"GO:1901228"(positive regulation of transcription from RNA polymerase II promoter involved in heart development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR016641(Nascent polypeptide-associated complex, alpha subunit)|interpro:IPR038187|interpro:IPR044034|mint:Q13765|rcsb pdb:3LKX|rcsb pdb:3MCB|rcsb pdb:3MCE|go:"GO:0043403"(skeletal muscle tissue regeneration)|refseq:NP_001106672.1|refseq:NP_001307122.1|refseq:NP_001307123.1|refseq:NP_005585.1|refseq:NP_001106673.1|refseq:NP_001106674.2|dip:DIP-43878N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l8QKB8mfSwvDDSSObGLQ7i1LgWo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04818	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190719|ensembl:ENSP00000315644|uniprotkb:Q8WYK3|uniprotkb:Q8WYK4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tysy_human(display_long)|uniprotkb:TYMS(gene name)|psi-mi:TYMS(display_short)|uniprotkb:TS(gene name synonym)|uniprotkb:OK/SW-cl.29(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000176890(gene)|ensembl:ENST00000323274(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0005542"(folic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0006235"(dTTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0019860"(uracil metabolic process)|go:"GO:0032259"(methylation)|go:"GO:0032570"(response to progesterone)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046683"(response to organophosphorus)|go:"GO:0048589"(developmental growth)|go:"GO:0051216"(cartilage development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051593"(response to folic acid)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|interpro:IPR023451|interpro:IPR036926|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019048"(modulation by virus of host process)|rcsb pdb:1HVY|rcsb pdb:4O1U|rcsb pdb:4O1X|rcsb pdb:4UP1|rcsb pdb:5HS3|rcsb pdb:5WRN|rcsb pdb:5X4W|rcsb pdb:5X4X|rcsb pdb:5X4Y|rcsb pdb:5X5A|rcsb pdb:4KPW|rcsb pdb:5X5D|rcsb pdb:5X5Q|rcsb pdb:5X66|rcsb pdb:5X67|rcsb pdb:5X69|rcsb pdb:6OJU|rcsb pdb:6OJV|rcsb pdb:6PF3|rcsb pdb:6PF4|rcsb pdb:6PF5|rcsb pdb:6PF6|rcsb pdb:6QXG|rcsb pdb:6QXH|rcsb pdb:6QYQ|rcsb pdb:6R2E|rcsb pdb:6ZXO|reactome:R-HSA-499943|reactome:R-HSA-69205|rcsb pdb:1HW4|rcsb pdb:1HZW|rcsb pdb:1I00|rcsb pdb:1JU6|rcsb pdb:1JUJ|rcsb pdb:1YPV|rcsb pdb:2ONB|rcsb pdb:2RD8|rcsb pdb:2RDA|rcsb pdb:3EAW|rcsb pdb:3EBU|rcsb pdb:3ED7|rcsb pdb:3EDW|rcsb pdb:3EF9|rcsb pdb:3EGY|rcsb pdb:3EHI|rcsb pdb:3EJL|rcsb pdb:3GG5|rcsb pdb:3GH0|rcsb pdb:3GH2|rcsb pdb:3H9K|rcsb pdb:3HB8|rcsb pdb:3N5E|rcsb pdb:3N5G|rcsb pdb:3OB7|rcsb pdb:4E28|rcsb pdb:4FGT|rcsb pdb:1HW3|rcsb pdb:4G2O|rcsb pdb:4G6W|rcsb pdb:4GD7|rcsb pdb:4GYH|rcsb pdb:4H1I|rcsb pdb:4JEF|go:"GO:0009636"(response to toxic substance)|go:"GO:0007568"(aging)|refseq:NP_001062.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9GWaP/MRO1tyHPXsZ+axd6j8lqM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99832	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62306	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356900|uniprotkb:A2VCR2|uniprotkb:Q15356|uniprotkb:Q6IBQ1|uniprotkb:Q6P4I0|uniprotkb:B2R498|ensembl:ENSP00000266735	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ruxf_human(display_long)|uniprotkb:SNRPF(gene name)|psi-mi:SNRPF(display_short)|uniprotkb:PBSCF(gene name synonym)|uniprotkb:Sm protein F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003086.1|ensembl:ENSG00000139343(gene)|ensembl:ENST00000266735(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|dip:DIP-31221N|rcsb pdb:5XJL|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6V4X|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-111367|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-73856|reactome:R-HSA-77588|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|interpro:IPR034100|mint:P62306|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2RggXu+kFj6wG7gTmxRHOIRvXiM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01085	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2820828|uniprotkb:A8K3T0|uniprotkb:A8K4L9|ensembl:ENSP00000394902	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tiar_human(display_long)|uniprotkb:TIAL1(gene name)|psi-mi:TIAL1(display_short)|uniprotkb:TIA-1-related protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001029097.1|refseq:NP_003243.1|ensembl:ENSG00000151923(gene)|ensembl:ENST00000436547(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007281"(germ cell development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017145"(stem cell division)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034492|interpro:IPR034494|interpro:IPR034496|interpro:IPR035979|mint:Q01085|rcsb pdb:1X4G|rcsb pdb:2CQI|rcsb pdb:2DH7|reactome:R-HSA-6803529|dip:DIP-42425N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dKWzIWmR/JaCJwsOLUPG2Z1uhH89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q07955	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50552	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08559	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50990	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356507|uniprotkb:A6NN54|uniprotkb:Q4VBP8|uniprotkb:B4DEM7|uniprotkb:B4DQH4|ensembl:ENSP00000286788	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpq_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:CCTQ(gene name synonym)|uniprotkb:KIAA0002(gene name synonym)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-15(gene name synonym)|uniprotkb:C21orf112(gene name synonym)|uniprotkb:Chaperonin containing T-complex polypeptide 1 subunit 8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001269836.1|refseq:NP_001269838.1|refseq:NP_006576.2|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50990|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|ensembl:ENSG00000156261(gene)|ensembl:ENST00000286788(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016887"(ATP hydrolysis activity)|reactome:R-HSA-6798695|reactome:R-HSA-6814122|reactome:R-HSA-5620922|dip:DIP-38124N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/TlB7Gk2Z9GPvfV3JBE0nWUF34Y9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O76021	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358028|uniprotkb:Q2M1T7|uniprotkb:Q6PL22|uniprotkb:Q8IWS7|uniprotkb:Q8WUZ1|uniprotkb:Q9HDA9|uniprotkb:Q9Y3Z9|uniprotkb:B4DJ58|uniprotkb:D3DUG7|ensembl:ENSP00000460871	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl1d1_human(display_long)|uniprotkb:RSL1D1(gene name)|psi-mi:RSL1D1(display_short)|uniprotkb:CSIG(gene name synonym)|uniprotkb:PBK1(gene name synonym)|uniprotkb:CATX11(gene name synonym)|uniprotkb:L12(orf name)|uniprotkb:Cellular senescence-inhibited gene protein(gene name synonym)|uniprotkb:Protein PBK1(gene name synonym)|uniprotkb:CATX-11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056474.2|ensembl:ENSG00000171490(gene)|ensembl:ENST00000571133(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030686"(90S preribosome)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023674|interpro:IPR028364|mint:O76021	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/mAkpodrvvZA6mz3M8VwHDEJzKo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UHV9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q53FZ2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190543|ensembl:ENSP00000289416|uniprotkb:O60363|uniprotkb:Q13732|uniprotkb:Q15425|uniprotkb:Q7KYM6|uniprotkb:Q9BUA2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:acsm3_human(display_long)|uniprotkb:Propionate--CoA ligase(gene name synonym)|uniprotkb:ACSM3(gene name)|psi-mi:ACSM3(display_short)|uniprotkb:SAH(gene name synonym)|uniprotkb:Acyl-CoA synthetase medium-chain family member 3(gene name synonym)|uniprotkb:Butyrate--CoA ligase 3(gene name synonym)|uniprotkb:Butyryl-coenzyme A synthetase 3(gene name synonym)|uniprotkb:Middle-chain acyl-CoA synthetase 3(gene name synonym)|uniprotkb:Protein SA homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR042099|reactome:R-HSA-77352|go:"GO:0047760"(butyrate-CoA ligase activity)|ensembl:ENSG00000005187(gene)|ensembl:ENST00000289416(transcript)|go:"GO:0004321"(fatty-acyl-CoA synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015645"(fatty acid ligase activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043759"(methylbutanoate-CoA ligase activity)|go:"GO:0046872"(metal ion binding)|refseq:NP_005613.2|refseq:NP_973729.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Do1rTLtpYet8Ez8zkBcq9SZnI8g9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3D9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054270|uniprotkb:Q96Q24|uniprotkb:Q9BWH8|uniprotkb:Q9P053|uniprotkb:B2R6V3|ensembl:ENSP00000320184	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rt23_human(display_long)|uniprotkb:MRPS23(gene name)|psi-mi:MRPS23(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS23(gene name synonym)|uniprotkb:CGI-138(orf name)|uniprotkb:HSPC329(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057154.2|ensembl:ENSG00000181610(gene)|ensembl:ENST00000313608(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0031965"(nuclear membrane)|interpro:IPR019520|interpro:IPR023611|mint:Q9Y3D9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6Iyu6KkT1Y0+n0LKWy5Gf0DkhHw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25789	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359310|uniprotkb:Q8TBD1|uniprotkb:Q53XP2|ensembl:ENSP00000044462|ensembl:ENSP00000453887|uniprotkb:D3DW86|uniprotkb:Q567Q5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa4_human(display_long)|uniprotkb:PSMA4(gene name)|psi-mi:PSMA4(display_short)|uniprotkb:PSC9(gene name synonym)|uniprotkb:Proteasome component C9(gene name synonym)|uniprotkb:Macropain subunit C9(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C9(gene name synonym)|uniprotkb:Proteasome subunit L(gene name synonym)|uniprotkb:HC9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001096137.1|refseq:NP_002780.1|rcsb pdb:6XMJ|reactome:R-HSA-2467813|reactome:R-HSA-2871837|rcsb pdb:7AWE|reactome:R-HSA-349425|reactome:R-HSA-1169091|reactome:R-HSA-350562|reactome:R-HSA-1234176|reactome:R-HSA-382556|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-450408|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5358346|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000041357(gene)|ensembl:ENST00000044462(transcript)|ensembl:ENST00000559082(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034647|mint:P25789|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|refseq:NP_001096138.1|refseq:NP_001317605.1|dip:DIP-29365N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u+wKxvIa9JKb4Zu9K+tnY3d26tw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92973	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286693|intact:EBI-1760498|uniprotkb:Q92957|uniprotkb:Q92975|intact:EBI-1965561|uniprotkb:B4DVC6|ensembl:ENSP00000336712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tnpo1_human(display_long)|uniprotkb:TRN(gene name synonym)|uniprotkb:TNPO1(gene name)|psi-mi:TNPO1(display_short)|uniprotkb:KPNB2(gene name synonym)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Importin beta-2(gene name synonym)|uniprotkb:Karyopherin beta-2(gene name synonym)|uniprotkb:M9 region interaction protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002261.3|refseq:NP_694858.1|refseq:XP_005248557.1|dip:DIP-29335N|ensembl:ENSG00000083312(gene)|ensembl:ENST00000337273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q92973|rcsb pdb:1QBK|rcsb pdb:2H4M|rcsb pdb:2OT8|rcsb pdb:2QMR|rcsb pdb:2Z5J|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:2Z5N|rcsb pdb:2Z5O|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:4JLQ|rcsb pdb:4OO6|rcsb pdb:5J3V|rcsb pdb:5TQC|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:7CYL|reactome:R-HSA-450513|reactome:R-HSA-5620924|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n8Q3n1rmTiJAp6f8DBcBV6j6lac9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6190532	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	-	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c9j6d7_human(display_short)|psi-mi:EBI-6190532(display_long)|uniprotkb:KIAA0664(gene name)|psi-mi:KIAA0664(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	uniprotkb:C9J6D7(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vIKw9yo22CTfO4A1eK7NsIpcGkI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00231	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BgQKXK7gMMihacRCI+g/pBnRN309606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P98179	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2949699|ensembl:ENSP00000365946|ensembl:ENSP00000365950	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm3_human(display_long)|uniprotkb:RBM3(gene name)|psi-mi:RBM3(display_short)|uniprotkb:RNPL(gene name synonym)|uniprotkb:RNA-binding motif protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030425"(dendrite)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:P98179|go:"GO:0006417"(regulation of translation)|ensembl:ENSG00000102317(gene)|ensembl:ENST00000376755(transcript)|ensembl:ENST00000376759(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|refseq:NP_006734.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+KPnDlgXy+KGVDjTilKMXb5dJGs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26639	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042683|uniprotkb:Q96FP5|uniprotkb:Q9BWA6|uniprotkb:A8K8I1|ensembl:ENSP00000265112|ensembl:ENSP00000424387|uniprotkb:B4DEG8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sytc_human(display_long)|uniprotkb:TARS1(gene name)|psi-mi:TARS1(display_short)|uniprotkb:TARS(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_689508.3|refseq:NP_001245367.1|rcsb pdb:4HWT|rcsb pdb:4P3N|rcsb pdb:4TTV|rcsb pdb:5XLN|reactome:R-HSA-379716|refseq:NP_001245366.1|go:"GO:0005829"(cytosol)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|ensembl:ENSG00000113407(gene)|interpro:IPR012676(TGS-like)|ensembl:ENST00000265112(transcript)|ensembl:ENST00000502553(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|mint:P26639|rcsb pdb:1WWT	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Z+rOaI1ZO1TQftfkRn1HhXUqDAk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y266	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96QK1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054634|uniprotkb:Q561W2|uniprotkb:Q9H016|uniprotkb:Q9H096|uniprotkb:Q9H4P3|uniprotkb:Q9H8J0|uniprotkb:Q9NRS7|uniprotkb:Q9NVG2|uniprotkb:Q9NX80|uniprotkb:Q9NZK2|ensembl:ENSP00000299138	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vps35_human(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:VPS35(gene name)|psi-mi:VPS35(display_short)|uniprotkb:MEM3(gene name synonym)|uniprotkb:TCCCTA00141(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060676.2|rcsb pdb:5F0J|rcsb pdb:5F0K|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:7BLN|rcsb pdb:7BLO|reactome:R-HSA-3238698|ensembl:ENSG00000069329(gene)|ensembl:ENST00000299138(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097422"(tubular endosome)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|rcsb pdb:2R17|dip:DIP-29076N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:EXkMduDQKNCdp876vGF5vna9t389606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07437	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BQ69	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5324932|ensembl:ENSP00000255681|uniprotkb:Q9UH96	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:macd1_human(display_long)|uniprotkb:MACROD1(gene name)|psi-mi:MACROD1(display_short)|uniprotkb:LRP16(gene name synonym)|uniprotkb:Protein LRP16(gene name synonym)|uniprotkb:MACRO domain-containing protein 1(gene name synonym)|uniprotkb:O-acetyl-ADP-ribose deacetylase MACROD1(gene name synonym)|uniprotkb:[Protein ADP-ribosylaspartate] hydrolase MACROD1(gene name synonym)|uniprotkb:[Protein ADP-ribosylglutamate] hydrolase MACROD1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000133315(gene)|ensembl:ENST00000255681(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0019213"(deacetylase activity)|go:"GO:0042278"(purine nucleoside metabolic process)|go:"GO:0051725"(protein de-ADP-ribosylation)|go:"GO:0140291"(peptidyl-glutamate ADP-deribosylation)|go:"GO:0140293"(ADP-ribosylglutamate hydrolase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR043472|rcsb pdb:2X47|rcsb pdb:6LH4|refseq:NP_054786.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7gwLLBJKnqqdb89NYKEAtOdmMdU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q06830	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49458	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350743|uniprotkb:Q6NVX0|uniprotkb:Q8WTW0|ensembl:ENSP00000305230|uniprotkb:A8K0N0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srp09_human(display_long)|uniprotkb:SRP9(gene name)|psi-mi:SRP9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4UYJ|refseq:NP_001123912.1|refseq:NP_003124.1|ensembl:ENSG00000143742(gene)|ensembl:ENST00000304786(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005785"(signal recognition particle receptor complex)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0045900"(negative regulation of translational elongation)|interpro:IPR008832(Signal recognition particle, SRP9 subunit)|interpro:IPR009018(Signal recognition particle, SRP9/SRP14 subunit)|interpro:IPR039432|interpro:IPR039914|mint:P49458|rcsb pdb:1E8O|rcsb pdb:1E8S|rcsb pdb:1RY1|rcsb pdb:4UYK|rcsb pdb:5AOX|rcsb pdb:7NFX|reactome:R-HSA-1799339|dip:DIP-6151N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y33fEeeXnma9oF7Fzs6zEGQjVBU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15102	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711522|uniprotkb:Q53X88|ensembl:ENSP00000262890|ensembl:ENSP00000444935	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pa1b3_human(display_long)|uniprotkb:PAFAH1B3(gene name)|psi-mi:PAFAH1B3(display_short)|uniprotkb:PAFAHG(gene name synonym)|uniprotkb:PAF acetylhydrolase 29 kDa subunit(gene name synonym)|uniprotkb:PAF-AH subunit gamma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016042"(lipid catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|interpro:IPR013830(Esterase, SGNH hydrolase-type)|interpro:IPR036514|mint:Q15102|reactome:R-HSA-6811436|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0016020"(membrane)|ensembl:ENSG00000079462(gene)|ensembl:ENST00000262890(transcript)|ensembl:ENST00000538771(transcript)|go:"GO:0003847"(1-alkyl-2-acetylglycerophosphocholine esterase activity)|go:"GO:0005737"(cytoplasm)|refseq:NP_001139411.1|refseq:NP_001139412.1|refseq:NP_002564.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yxVKkXAs2AmH+fZFUW+hZN889k89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43684	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050987|uniprotkb:O43685|uniprotkb:B2R6E7|uniprotkb:A6NJ42|uniprotkb:D3DRE9|ensembl:ENSP00000357858	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bub3_human(display_long)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001007794.1|refseq:NP_004716.1|ensembl:ENSG00000154473(gene)|ensembl:ENST00000368865(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR020472|interpro:IPR036322|mint:O43684|reactome:R-HSA-141430|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|dip:DIP-24205N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nqzARPql2cThSUpxSb6PuTRn51E9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355710|uniprotkb:A8JZY8|ensembl:ENSP00000280326|uniprotkb:A8K2X8|uniprotkb:B4DYD8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpe_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)|uniprotkb:CCTE(gene name synonym)|uniprotkb:KIAA0098(gene name synonym)|uniprotkb:CCT-epsilon(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036205.1|ensembl:ENSG00000150753(gene)|ensembl:ENST00000280326(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|refseq:NP_001293084.1|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P48643|rcsb pdb:5UYX|rcsb pdb:5UYZ|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR012718(T-complex protein 1, epsilon subunit)|dip:DIP-31181N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u7uFkOYrDKL0gGvC24p34tQHhcw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07737	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713780|ensembl:ENSP00000225655|uniprotkb:Q53Y44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prof1_human(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:PFN1(gene name)|psi-mi:PFN1(display_short)|uniprotkb:Epididymis tissue protein Li 184a(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108518(gene)|ensembl:ENST00000225655(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P07737|rcsb pdb:1AWI|rcsb pdb:1CF0|rcsb pdb:1CJF|rcsb pdb:1FIK|rcsb pdb:1FIL|rcsb pdb:1PFL|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|rcsb pdb:4X1L|rcsb pdb:4X1M|rcsb pdb:4X25|rcsb pdb:6NAS|rcsb pdb:6NBE|rcsb pdb:6NBW|reactome:R-HSA-114608|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|reactome:R-HSA-4086400|reactome:R-HSA-5663220|reactome:R-HSA-376176|refseq:NP_005013.1|dip:DIP-30N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CncaC5RMylvzFLhqzpS+VbhQn6I9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61224	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50897	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32322	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15185	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26640	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355765|uniprotkb:Q5JQ90|uniprotkb:Q96E77|uniprotkb:Q9UQM2|uniprotkb:B4DZ61|uniprotkb:B0V1N1|ensembl:ENSP00000211402|ensembl:ENSP00000364815|ensembl:ENSP00000401121|ensembl:ENSP00000403359|ensembl:ENSP00000415316	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syvc_human(display_long)|uniprotkb:VARS1(gene name)|psi-mi:VARS1(display_short)|uniprotkb:G7A(gene name synonym)|uniprotkb:Protein G7a(gene name synonym)|uniprotkb:VARS(gene name synonym)|uniprotkb:VARS2(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006286.1|ensembl:ENSG00000096171(gene)|ensembl:ENSG00000204394(gene)|ensembl:ENSG00000224264(gene)|ensembl:ENSG00000226589(gene)|ensembl:ENSG00000231116(gene)|ensembl:ENST00000211402(transcript)|ensembl:ENST00000375663(transcript)|ensembl:ENST00000422694(transcript)|ensembl:ENST00000435657(transcript)|ensembl:ENST00000457796(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|interpro:IPR036282|interpro:IPR037118|mint:P26640|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aPfpK0/C2KpCsMOI0sjCreufI509606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49411	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359097|uniprotkb:O15276|ensembl:ENSP00000322439	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eftu_human(display_long)|uniprotkb:TUFM(gene name)|psi-mi:TUFM(display_short)|uniprotkb:P43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003312.3|ensembl:ENSG00000178952(gene)|ensembl:ENST00000313511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004541(Translation elongation factor EFTu/EF1A, bacterial and organelle)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|interpro:IPR033720|interpro:IPR041709|mint:P49411|rcsb pdb:7A5G|rcsb pdb:7O9K|reactome:R-HSA-5389840|refseq:XP_016879108.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pDRPUBUqvFqnh613N8bDTl4sFHc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PB61	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190851|ensembl:ENSP00000421592	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pb61_human(display_long)|uniprotkb:ALYREF(gene name)|psi-mi:ALYREF(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000183684(gene)|ensembl:ENST00000505490(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR025715|interpro:IPR035979|go:"GO:0016607"(nuclear speck)|refseq:NP_005773.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1TYm+flGafmObpUMr0SV5tuEDR49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62316	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297993|uniprotkb:P43330|ensembl:ENSP00000342374|ensembl:ENSP00000465216|uniprotkb:A8K797|uniprotkb:J3KPM5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd2_human(display_long)|uniprotkb:SNRPD2(gene name)|psi-mi:SNRPD2(display_short)|uniprotkb:snRNP core protein D2(gene name synonym)|uniprotkb:SNRPD1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000125743(gene)|ensembl:ENST00000342669(transcript)|ensembl:ENST00000588301(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027248|mint:P62316|rcsb pdb:1B34|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5XJL|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_004588.1|refseq:NP_808210.2|dip:DIP-31219N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4OshNPT6N4dOcWMVXrF5Fm8dcnI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08J23	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642839|intact:EBI-2839052|uniprotkb:A8K529|uniprotkb:B3KP09|uniprotkb:G3V1R4|uniprotkb:Q9BVN4|uniprotkb:Q9H858|uniprotkb:Q9NXD9|uniprotkb:B2RNR4|intact:EBI-2556652|uniprotkb:B4DQW2|ensembl:ENSP00000264670	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nsun2_human(display_long)|uniprotkb:NSUN2(gene name)|psi-mi:NSUN2(display_short)|uniprotkb:SAKI(gene name synonym)|uniprotkb:TRM4(gene name synonym)|uniprotkb:NOL1/NOP2/Sun domain family member 2(gene name synonym)|uniprotkb:tRNA methyltransferase 4 homolog(gene name synonym)|uniprotkb:Substrate of AIM1/Aurora kinase B(gene name synonym)|uniprotkb:Myc-induced SUN domain-containing protein(gene name synonym)|uniprotkb:"mRNA cytosine C(5)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA cytosine C(5)-methyltransferase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001180384.1|refseq:NP_060225.4|dip:DIP-52456N|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0006400"(tRNA modification)|go:"GO:0007286"(spermatid development)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016428"("tRNA (cytosine-5-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0033313"(meiotic cell cycle checkpoint signaling)|go:"GO:0033391"(chromatoid body)|go:"GO:0036416"(tRNA stabilization)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051301"(cell division)|go:"GO:0062152"("mRNA (cytidine-5-)-methyltransferase activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0080009"(mRNA methylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR023267|interpro:IPR023270|interpro:IPR029063|mint:Q08J23|reactome:R-HSA-6782315|ensembl:ENSG00000037474(gene)|ensembl:ENST00000264670(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001510"(RNA methylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k3hK/9cjuy5c4PyDGgCt0LsVtdo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y316	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1104564|uniprotkb:Q5R2V9|uniprotkb:Q6NSL5|uniprotkb:D6W575|uniprotkb:B4DLS0|uniprotkb:Q5R2V8|ensembl:ENSP00000385557|ensembl:ENSP00000295065	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:memo1_human(display_long)|uniprotkb:MEMO1(gene name)|psi-mi:MEMO1(display_short)|uniprotkb:CGI-27(orf name)|uniprotkb:Mediator of ErbB2-driven cell motility 1(gene name synonym)|uniprotkb:C2orf4(gene name synonym)|uniprotkb:NS5ATP7(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 7(gene name synonym)|uniprotkb:C21orf19-like protein(gene name synonym)|uniprotkb:MEMO(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001288762.1|refseq:NP_001288781.1|refseq:NP_001131074.1|refseq:NP_057039.1|refseq:XP_011531194.1|refseq:XP_016859744.1|ensembl:ENST00000295065(transcript)|ensembl:ENST00000404530(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0032886"(regulation of microtubule-based process)|interpro:IPR002737(Protein of unknown function DUF52)|rcsb pdb:3BCZ|rcsb pdb:3BD0|reactome:R-HSA-6785631|ensembl:ENSG00000162959(gene)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RL1cWMim2S2Bu+BTlRkdTHnJLxg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51692	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15154	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UKD2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1046493|ensembl:ENSP00000364320|uniprotkb:Q9BPV9|uniprotkb:Q5TG55|uniprotkb:Q96SS6|uniprotkb:B3KNB3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mrt4_human(display_long)|uniprotkb:MRTO4(gene name)|psi-mi:MRTO4(display_short)|uniprotkb:C1orf33(gene name synonym)|uniprotkb:MRT4(gene name synonym)|uniprotkb:Ribosome assembly factor MRTO4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000053372(gene)|ensembl:ENST00000330263(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:Q9UKD2|interpro:IPR033867|refseq:NP_057267.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LpvX3By1Cp6MxlAx3d5qoDM3FNY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15126	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055562|uniprotkb:Q5TZW9|ensembl:ENSP00000357452	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pmvk_human(display_long)|uniprotkb:PMVK(gene name)|psi-mi:PMVK(display_short)|uniprotkb:PMKI(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006547.1|ensembl:ENSG00000163344(gene)|ensembl:ENST00000368467(transcript)|go:"GO:0004631"(phosphomevalonate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0019287"(isopentenyl diphosphate biosynthetic process, mevalonate pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070723"(response to cholesterol)|interpro:IPR005919(Higher eukaryotic phosphomevalonate kinase)|interpro:IPR027417|mint:Q15126|rcsb pdb:3CH4|reactome:R-HSA-191273|reactome:R-HSA-2426168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bDsF+xduPQB+HVXbNikncal5foo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WUM4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-310624|uniprotkb:Q9BX86|uniprotkb:Q9NUN0|uniprotkb:Q9P2H2|uniprotkb:Q9UKL5|uniprotkb:C5MQH7|intact:EBI-10971645|uniprotkb:E9PFU1|uniprotkb:Q6NUS1|ensembl:ENSP00000307387|intact:EBI-28983290	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdc6i_human(display_long)|uniprotkb:PDCD6IP(gene name)|psi-mi:PDCD6IP(display_short)|uniprotkb:AIP1(gene name synonym)|uniprotkb:KIAA1375(gene name synonym)|uniprotkb:ALIX(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:Hp95(gene name synonym)|uniprotkb:ALG-2-interacting protein X(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_037506.2|ensembl:ENSP00000307387|ensembl:ENST00000457054|ensembl:ENSP00000411825|refseq:NP_001155901.1|ensembl:ENSG00000170248(gene)|ensembl:ENST00000307296(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q8WUM4|rcsb pdb:2OEV|rcsb pdb:2OEW|rcsb pdb:2OEX|rcsb pdb:2OJQ|rcsb pdb:2R02|rcsb pdb:2R03|rcsb pdb:2R05|rcsb pdb:2XS1|rcsb pdb:2XS8|rcsb pdb:2ZNE|rcsb pdb:3C3O|rcsb pdb:3C3Q|rcsb pdb:3C3R|rcsb pdb:3E1R|rcsb pdb:3WUV|rcsb pdb:4JJY|rcsb pdb:5V3R|rcsb pdb:5WA1|rcsb pdb:6KP3|reactome:R-HSA-162588|reactome:R-HSA-5210891|reactome:R-HSA-5213460|reactome:R-HSA-5675482|refseq:NP_001243121.1|dip:DIP-29327N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FYD19EyMBAGl204Xlgr4MlE8GMs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BSD7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2689235|ensembl:ENSP00000355587	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ntpcr_human(display_long)|uniprotkb:Nucleoside triphosphate phosphohydrolase(gene name synonym)|uniprotkb:NTPCR(gene name)|psi-mi:NTPCR(display_short)|uniprotkb:C1orf57(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_115700.1|interpro:IPR027417|mint:Q9BSD7|rcsb pdb:2I3B|ensembl:ENSG00000135778(gene)|ensembl:ENST00000366628(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004948(Protein of unknown function DUF265)|refseq:NP_001316382.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tJoP+XQzoa4urq6g1rdZhMWO49g9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BZL1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-607755|ensembl:ENSP00000351492|ensembl:ENSP00000466910|ensembl:ENSP00000468656|uniprotkb:Q2NL89	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubl5_human(display_long)|uniprotkb:UBL5(gene name)|psi-mi:UBL5(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198258(gene)|ensembl:ENST00000358666(transcript)|ensembl:ENST00000586895(transcript)|ensembl:ENST00000590068(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0031386"(protein tag)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039732|rcsb pdb:1P0R|rcsb pdb:4PYU|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:6AHD|refseq:NP_001041706.1|refseq:NP_077268.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tm6rC2ylXI3og2IqNXSHmgi2f/09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19623	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056183|uniprotkb:Q15511|uniprotkb:B1AKP9|ensembl:ENSP00000366156	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:spee_human(display_long)|uniprotkb:SRM(gene name)|psi-mi:SRM(display_short)|uniprotkb:SPS1(gene name synonym)|uniprotkb:SRML1(gene name synonym)|uniprotkb:Putrescine aminopropyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003123.2|ensembl:ENSG00000116649(gene)|ensembl:ENST00000376957(transcript)|go:"GO:0004766"(spermidine synthase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0006596"(polyamine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001045(Spermine synthase)|interpro:IPR029063|interpro:IPR030373|interpro:IPR030374|interpro:IPR030668|interpro:IPR035246|interpro:IPR037163|rcsb pdb:2O05|rcsb pdb:2O06|rcsb pdb:2O07|rcsb pdb:2O0L|rcsb pdb:3RW9|reactome:R-HSA-351202	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VNjR3N2SwRzXIokl23Lis1pV3Pg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15153	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489652|ensembl:ENSP00000249071|uniprotkb:Q9UDJ4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rac2_human(display_long)|uniprotkb:p21-Rac2(gene name synonym)|uniprotkb:Small G protein(gene name synonym)|uniprotkb:GX(gene name synonym)|uniprotkb:RAC2(gene name)|psi-mi:RAC2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045453"(bone resorption)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060753"(regulation of mast cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P15153|rcsb pdb:1DS6|rcsb pdb:2W2T|rcsb pdb:2W2V|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-1222556|go:"GO:0043304"(regulation of mast cell degranulation)|ensembl:ENSG00000128340(gene)|ensembl:ENST00000249071(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0005925"(focal adhesion)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|reactome:R-HSA-1257604|refseq:NP_002863.1|reactome:R-HSA-2219530|reactome:R-HSA-4086400|reactome:R-HSA-5668599|reactome:R-HSA-6811558|reactome:R-HSA-9013404|dip:DIP-34291N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NYkPt/WNmKM3qAhhaufLCPkc/io9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N1F7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042703|uniprotkb:Q14705|uniprotkb:B3KPQ8|ensembl:ENSP00000310668	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nup93_human(display_long)|uniprotkb:NUP93(gene name)|psi-mi:NUP93(display_short)|uniprotkb:KIAA0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055484.3|refseq:NP_001229724.1|refseq:NP_001229725.1|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8N1F7|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|ensembl:ENSG00000102900(gene)|reactome:R-HSA-168271|ensembl:ENST00000308159(transcript)|go:"GO:0005635"(nuclear envelope)|reactome:R-HSA-168276|go:"GO:0005643"(nuclear pore)|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-191859|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005256320.1|dip:DIP-44020N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pkk5pooUC4yQShpqjiwNLddfy149606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99623	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:h4pib54mBeQgOKCe/hib58LM26w9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15365	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-923010|uniprotkb:Q9UGU3|intact:EBI-1056800|uniprotkb:Q20WK5|ensembl:ENSP00000216129	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ttl12_human(display_long)|uniprotkb:TTLL12(gene name)|psi-mi:TTLL12(display_short)|uniprotkb:KIAA0153(gene name synonym)|uniprotkb:Inactive tubulin--tyrosine ligase-like protein 12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055955.1|ensembl:ENSG00000100304(gene)|ensembl:ENST00000216129(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015631"(tubulin binding)|go:"GO:0030496"(midbody)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0045087"(innate immune response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:1990889"(H4K20me3 modified histone binding)|interpro:IPR004344(Tubulin-tyrosine ligase)|interpro:IPR027749|reactome:R-HSA-8955332	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MXpuEK/k1S+fNxRGLpFGTO2YH2g9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17987	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P258	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352547|uniprotkb:Q8IVL9|uniprotkb:Q9BSN6|uniprotkb:Q9NPV8|ensembl:ENSP00000364582|ensembl:ENSP00000364585|ensembl:ENSP00000486099|ensembl:ENSP00000486447	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rcc2_human(display_long)|uniprotkb:RCC2(gene name)|psi-mi:RCC2(display_short)|uniprotkb:KIAA1470(gene name synonym)|uniprotkb:TD60(gene name synonym)|uniprotkb:Telophase disk protein of 60 kDa(gene name synonym)|uniprotkb:RCC1-like protein TD-60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129676.1|refseq:NP_061185.1|ensembl:ENSG00000179051(gene)|ensembl:ENSG00000281540(gene)|ensembl:ENST00000375433(transcript)|ensembl:ENST00000375436(transcript)|ensembl:ENST00000628984(transcript)|ensembl:ENST00000631021(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR028641|mint:Q9P258|rcsb pdb:5GWN|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:z9+0avftBLs4Q3ODFHLEmJtd57A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3C6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2557649|uniprotkb:Q5TDC9|uniprotkb:O15001|ensembl:ENSP00000362803	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppil1_human(display_long)|uniprotkb:PPIL1(gene name)|psi-mi:PPIL1(display_short)|uniprotkb:Rotamase PPIL1(gene name synonym)|uniprotkb:CYPL1(gene name synonym)|uniprotkb:CGI-124(orf name)|uniprotkb:UNQ2425/PRO4984(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057143.1|ensembl:ENSG00000137168(gene)|ensembl:ENST00000373699(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|interpro:IPR044666|rcsb pdb:1XWN|rcsb pdb:2K7N|rcsb pdb:2X7K|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|reactome:R-HSA-72163|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4Wx4abxOz/ayhkwVy/JYzA3d+SE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O76003	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374781|uniprotkb:Q96CE0|uniprotkb:Q9P1B0|uniprotkb:Q9P1B1|uniprotkb:B3KMP7|uniprotkb:B3KMQ5|uniprotkb:Q5JV01|ensembl:ENSP00000330836|ensembl:ENSP00000357633|ensembl:ENSP00000435445|uniprotkb:D3DRG2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:glrx3_human(display_long)|uniprotkb:GLRX3(gene name)|psi-mi:GLRX3(display_short)|uniprotkb:Thioredoxin-like protein 2(gene name synonym)|uniprotkb:PKC-interacting cousin of thioredoxin(gene name synonym)|uniprotkb:PKC-theta-interacting protein(gene name synonym)|uniprotkb:PICOT(gene name synonym)|uniprotkb:HUSSY-22(orf name)|uniprotkb:TXNL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108010(gene)|ensembl:ENST00000331244(transcript)|ensembl:ENST00000368644(transcript)|ensembl:ENST00000481034(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0097573"(glutathione oxidoreductase activity)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249|mint:O76003|rcsb pdb:2DIY|rcsb pdb:2WZ9|rcsb pdb:2YAN|rcsb pdb:3ZYW|reactome:R-HSA-917937|refseq:NP_001186797.1|refseq:NP_006532.2|dip:DIP-31306N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iKUSt6zbNzzXSKvW+vXMq3hKsEM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30626	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750459|uniprotkb:D6W5Q0|intact:EBI-2623494|uniprotkb:A8MTH6|uniprotkb:B4DKK2|ensembl:ENSP00000265729	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sorcn_human(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_944490.1|refseq:NP_003121.1|refseq:NP_001243820.1|refseq:NP_001243821.1|dip:DIP-40970N|ensembl:ENSG00000075142(gene)|ensembl:ENST00000265729(transcript)|go:"GO:0001508"(action potential)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|rcsb pdb:2JC2|rcsb pdb:4U8D|rcsb pdb:4UPG|rcsb pdb:4USL|rcsb pdb:5MRA|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P30626|rcsb pdb:1JUO	-	-	crc64:A4829C7650A5E3FA	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:upE31IMimaotkgnYa7HYr7EYAxc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61026	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-726075|uniprotkb:O88386|uniprotkb:Q6IA52|uniprotkb:Q9D7X6|uniprotkb:Q9H0T3|uniprotkb:D6W538|ensembl:ENSP00000264710	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab10_human(display_long)|uniprotkb:RAB10(gene name)|psi-mi:RAB10(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057215.3|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:5LPN|rcsb pdb:5SZJ|reactome:R-HSA-1445148|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000084733(gene)|ensembl:ENST00000264710(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35658	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NP79	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-740160|uniprotkb:Q5TGM1|uniprotkb:Q6IAE8|uniprotkb:Q9H0R2|uniprotkb:Q9H3K9|uniprotkb:Q9P0Q0|uniprotkb:E1P594|ensembl:ENSP00000356602|uniprotkb:B4DW55|uniprotkb:E7ETQ7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vta1_human(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:HSPC228(orf name)|uniprotkb:My012(orf name)|uniprotkb:SKD1-binding protein 1(gene name synonym)|uniprotkb:C6orf55(gene name synonym)|uniprotkb:Dopamine-responsive gene 1 protein(gene name synonym)|uniprotkb:LYST-interacting protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001273300.1|refseq:NP_001273301.1|refseq:NP_057569.2|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:4U7E|reactome:R-HSA-162588|reactome:R-HSA-917729|ensembl:ENSG00000009844(gene)|ensembl:ENST00000367630(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LXL|rcsb pdb:2LXM|rcsb pdb:4TXP	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QIeYrvtJGJ2jWli8PWK9TeO6gus9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35232	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09874	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13526	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10599	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-594644|uniprotkb:B1ALW1|uniprotkb:O60744|uniprotkb:Q53X69|uniprotkb:Q96KI3|uniprotkb:Q9UDG5|intact:EBI-1042712|ensembl:ENSP00000363641	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:thio_human(display_long)|uniprotkb:ATL-derived factor(gene name synonym)|uniprotkb:Surface-associated sulphydryl protein(gene name synonym)|uniprotkb:TXN(gene name)|psi-mi:TXN(display_short)|uniprotkb:TRDX(gene name synonym)|uniprotkb:TRX(gene name synonym)|uniprotkb:TRX1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003320.2|refseq:NP_001231867.1|dip:DIP-6129N|ensembl:ENSG00000136810(gene)|ensembl:ENST00000374517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006662"(glycerol ether metabolic process)|go:"GO:0009314"(response to radiation)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071731"(response to nitric oxide)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR005746(Thioredoxin)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P10599|rcsb pdb:1AIU|rcsb pdb:1AUC|rcsb pdb:1CQG|rcsb pdb:1CQH|rcsb pdb:1ERT|rcsb pdb:1ERU|rcsb pdb:1ERV|rcsb pdb:1ERW|rcsb pdb:1M7T|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1TRS|rcsb pdb:1TRU|rcsb pdb:1TRV|rcsb pdb:1TRW|rcsb pdb:1W1C|rcsb pdb:1W1E|rcsb pdb:2HSH|rcsb pdb:2HXK|rcsb pdb:2IFQ|rcsb pdb:2IIY|rcsb pdb:3E3E|rcsb pdb:3KD0|rcsb pdb:3M9J|rcsb pdb:3M9K|rcsb pdb:3QFA|rcsb pdb:3QFB|rcsb pdb:3TRX|rcsb pdb:4LL1|rcsb pdb:4LL4|rcsb pdb:4OO4|rcsb pdb:4OO5|rcsb pdb:4POK|rcsb pdb:4POL|rcsb pdb:4POM|rcsb pdb:4PUF|rcsb pdb:4TRX|rcsb pdb:5DQY|reactome:R-HSA-2559580|reactome:R-HSA-3299685|reactome:R-HSA-499943|reactome:R-HSA-5628897|reactome:R-HSA-5676934|reactome:R-HSA-844456|reactome:R-HSA-9617629|reactome:R-HSA-9660826	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5u+iJJtwAwAKXljKHnpY8h5uRkQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13148	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P68371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351356|uniprotkb:P05217|uniprotkb:A2BFA2|ensembl:ENSP00000341289	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb4b_human(display_long)|uniprotkb:TUBB4B(gene name)|psi-mi:TUBB4B(display_short)|uniprotkb:TUBB2C(gene name synonym)|uniprotkb:Tubulin beta-2 chain(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006079.1|ensembl:ENSG00000188229(gene)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|go:"GO:0005200"(structural constituent of cytoskeleton)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68371|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|ensembl:ENST00000340384(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4LwMs7E7eILMjB9Z/1bstAp22CY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00059	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31151	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357520|uniprotkb:Q6FGE3|uniprotkb:Q5SY67|uniprotkb:Q9H1E2|ensembl:ENSP00000357711|ensembl:ENSP00000357712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:s10a7_human(display_long)|uniprotkb:S100A7(gene name)|psi-mi:S100A7(display_short)|uniprotkb:PSOR1(gene name synonym)|uniprotkb:S100A7C(gene name synonym)|uniprotkb:S100 calcium-binding protein A7(gene name synonym)|uniprotkb:Psoriasin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000143556(gene)|ensembl:ENST00000368722(transcript)|ensembl:ENST00000368723(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008544"(epidermis development)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051238"(sequestering of metal ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071624"(positive regulation of granulocyte chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028477|interpro:IPR034325|mint:P31151|rcsb pdb:1PSR|rcsb pdb:2PSR|rcsb pdb:2WND|rcsb pdb:2WOR|rcsb pdb:2WOS|rcsb pdb:3PSR|rcsb pdb:4AQJ|reactome:R-HSA-6798695|reactome:R-HSA-6799990|refseq:NP_002954.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/v8+XQ7rCMTYzq9k/KqjcSm/G0A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43678	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bL66utte1nSuYj0nxg/BoktnXhs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18206	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716775|uniprotkb:Q16450|uniprotkb:Q5SWX2|uniprotkb:Q7Z3B8|uniprotkb:Q8IXU7|ensembl:ENSP00000211998	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vinc_human(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003364.1|refseq:NP_054706.1|ensembl:ENSG00000035403(gene)|ensembl:ENST00000211998(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P18206|rcsb pdb:1RKC|rcsb pdb:1RKE|rcsb pdb:1SYQ|rcsb pdb:1TR2|rcsb pdb:1YDI|rcsb pdb:2GWW|rcsb pdb:2HSQ|rcsb pdb:2IBF|rcsb pdb:3H2U|rcsb pdb:3H2V|rcsb pdb:3JBK|rcsb pdb:3MYI|rcsb pdb:3RF3|rcsb pdb:3S90|go:"GO:0005198"(structural molecule activity)|rcsb pdb:3TJ5|rcsb pdb:3TJ6|rcsb pdb:3VF0|rcsb pdb:4DJ9|rcsb pdb:4EHP|rcsb pdb:4LN2|rcsb pdb:4LNP|rcsb pdb:4PR9|rcsb pdb:5L0C|rcsb pdb:5L0D|rcsb pdb:5L0F|rcsb pdb:5L0G|rcsb pdb:5L0H|rcsb pdb:5L0I|rcsb pdb:5L0J|rcsb pdb:5O2Q|rcsb pdb:6FUY|rcsb pdb:6UPW|rcsb pdb:7KTT|rcsb pdb:7KTU|rcsb pdb:7KTV|rcsb pdb:7KTW|reactome:R-HSA-114608|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|ensembl:ENSP00000211998|ensembl:ENST00000372755|ensembl:ENSP00000361841|dip:DIP-35570N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Cs5ZD4u5mH3IHBeKWMRV4cfS+y49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:F2Z393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190784|ensembl:ENSP00000437098	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:f2z393_human(display_long)|uniprotkb:TALDO1(gene name)|psi-mi:TALDO1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000177156(gene)|ensembl:ENST00000528097(transcript)|go:"GO:0004801"(transaldolase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|interpro:IPR001585(Transaldolase)|interpro:IPR004730(Transaldolase AB)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR018225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HsQeEQ7VSDjAj16nSteErpQ1F309606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02100	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190240|ensembl:ENSP00000292896|ensembl:ENSP00000369586|ensembl:ENSP00000380104|uniprotkb:Q6FH44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbe_human(display_long)|uniprotkb:HBE1(gene name)|psi-mi:HBE1(display_short)|uniprotkb:HBE(gene name synonym)|uniprotkb:Epsilon-globin(gene name synonym)|uniprotkb:Hemoglobin epsilon chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000213931(gene)|ensembl:ENST00000292896(transcript)|ensembl:ENST00000380237(transcript)|ensembl:ENST00000396895(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1A9W|reactome:R-HSA-983231|refseq:NP_005321.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZKgpsS0AFjNRaxSJ4ctde2ESHik9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11021	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06730	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73440|uniprotkb:Q96E95|ensembl:ENSP00000389624|uniprotkb:D6RCQ6|uniprotkb:B7Z6V1|intact:EBI-28969298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4e_human(display_long)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:EIF4E(gene name)|psi-mi:EIF4E(display_short)|uniprotkb:EIF4EL1(gene name synonym)|uniprotkb:EIF4F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001124151.1|refseq:NP_001959.1|ensembl:ENST00000280892|ensembl:ENSP00000280892|ensembl:ENSP00000389624|ensembl:ENST00000505992|ensembl:ENSP00000425561|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:2W97|rcsb pdb:3AM7|rcsb pdb:3TF2|rcsb pdb:3U7X|rcsb pdb:4AZA|rcsb pdb:4BEA|rcsb pdb:4DT6|rcsb pdb:4DUM|rcsb pdb:4TPW|rcsb pdb:4TQB|rcsb pdb:4TQC|rcsb pdb:4UED|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5EKV|rcsb pdb:5GW6|rcsb pdb:5T46|rcsb pdb:5ZJY|rcsb pdb:5ZJZ|rcsb pdb:5ZK5|rcsb pdb:5ZK7|rcsb pdb:5ZK9|ensembl:ENSG00000151247(gene)|rcsb pdb:5ZML|rcsb pdb:7MEU|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-159231|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-159230|reactome:R-HSA-159227|ensembl:ENST00000450253(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|mint:P06730|rcsb pdb:1IPB|rcsb pdb:1IPC|rcsb pdb:1WKW|rcsb pdb:2GPQ|rcsb pdb:2V8W|refseq:NP_001124150.1|refseq:NP_001317946.1|dip:DIP-22N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9173bxjOdBfKj36pWVvzw7M6g1A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P45880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:seQxCd19Z2HmpXcwb48osAuuafA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27708	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355504|uniprotkb:Q6P0Q0|uniprotkb:D6W552|ensembl:ENSP00000264705|uniprotkb:Q96CK3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pyr1_human(display_long)|uniprotkb:CAD(gene name)|psi-mi:CAD(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004332.2|ensembl:ENSG00000084774(gene)|ensembl:ENST00000264705(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070335"(aspartate binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:P27708|go:"GO:0016020"(membrane)|rcsb pdb:4BY3|rcsb pdb:4C6B|rcsb pdb:4C6C|rcsb pdb:4C6D|rcsb pdb:4C6E|rcsb pdb:4C6F|rcsb pdb:4C6I|rcsb pdb:4C6J|rcsb pdb:4C6K|rcsb pdb:4C6L|rcsb pdb:4C6M|rcsb pdb:4C6N|rcsb pdb:4C6O|rcsb pdb:4C6P|rcsb pdb:4C6Q|rcsb pdb:5G1N|rcsb pdb:5G1O|rcsb pdb:5G1P|rcsb pdb:5YNZ|rcsb pdb:6HFD|rcsb pdb:6HFE|rcsb pdb:6HFF|rcsb pdb:6HFH|rcsb pdb:6HFI|rcsb pdb:6HFJ|rcsb pdb:6HFK|rcsb pdb:6HFL|rcsb pdb:6HFP|rcsb pdb:6HFQ|rcsb pdb:6HFR|rcsb pdb:6HFS|rcsb pdb:6HFU|rcsb pdb:6HG1|reactome:R-HSA-500753|rcsb pdb:6HFN|refseq:NP_001293008.1|dip:DIP-39484N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m5iR4BQz6t2dbQxtP1MARVW0LAw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N163	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:H0YHG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190012|ensembl:ENSP00000447000	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h0yhg0_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000257390(gene)|ensembl:ENST00000546837(transcript)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR032843|interpro:IPR036361|interpro:IPR036869	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Rb4NKPkoUZDm37vByGa9J2Vlbm09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42677	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356336|ensembl:ENSP00000499044|uniprotkb:Q5T4L6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs27_human(display_long)|uniprotkb:RPS27(gene name)|psi-mi:RPS27(display_short)|uniprotkb:MPS1(gene name synonym)|uniprotkb:Metallopan-stimulin 1(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS27(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001021.1|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000177954(gene)|ensembl:ENST00000651669(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407|mint:P42677|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-141444|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-2500257|rcsb pdb:6OM7|reactome:R-HSA-5663220|reactome:R-HSA-6791226|reactome:R-HSA-68877|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-9648025|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-44182N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OA5IWAJDBpY5FFdVnun7Sq/jI7g9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61604	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711483|uniprotkb:O95421|uniprotkb:Q04984|uniprotkb:Q53X54|ensembl:ENSP00000233893|uniprotkb:Q9UDH0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch10_human(display_long)|uniprotkb:HSPE1(gene name)|psi-mi:HSPE1(display_short)|uniprotkb:10 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 10(gene name synonym)|uniprotkb:Early-pregnancy factor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR020818|interpro:IPR037124|mint:P61604|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|reactome:R-HSA-9013408|ensembl:ENSG00000115541(gene)|ensembl:ENST00000233893(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011032(GroES-like)|interpro:IPR018369|refseq:NP_002148.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BmnGoMnA2QIr3Dr0fElMtTgRztA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54136	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355482|uniprotkb:Q9BWA1|uniprotkb:B2RBS9|uniprotkb:Q53GY4|intact:EBI-28985219|ensembl:ENSP00000231572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syrc_human(display_long)|uniprotkb:RARS1(gene name)|psi-mi:RARS1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:RARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002878.2|ensembl:ENSG00000113643(gene)|ensembl:ENST00000231572(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:P54136|rcsb pdb:4Q2T|rcsb pdb:4Q2X|rcsb pdb:4Q2Y|rcsb pdb:4R3Z|rcsb pdb:4ZAJ|reactome:R-HSA-2408522|reactome:R-HSA-379716|ensembl:ENSP00000231572	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oM9gWF1NucjgVjBFm4DcjmnQNCE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NZI8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053892|uniprotkb:C9JT33|ensembl:ENSP00000290341	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2b1_human(display_long)|uniprotkb:ZBP1(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 1(gene name synonym)|uniprotkb:Coding region determinant-binding protein(gene name synonym)|uniprotkb:VICKZ family member 1(gene name synonym)|uniprotkb:IGF2BP1(gene name)|psi-mi:IGF2BP1(display_short)|uniprotkb:Zipcode-binding protein 1(gene name synonym)|uniprotkb:CRDBP(gene name synonym)|uniprotkb:VICKZ1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006537.3|refseq:NP_001153895.1|ensembl:ENSG00000159217(gene)|ensembl:ENST00000290341(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010610"(regulation of mRNA stability involved in response to stress)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022013"(pallium cell proliferation in forebrain)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140059"(dendrite arborization)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034837|interpro:IPR034842|interpro:IPR035979|interpro:IPR036612|mint:Q9NZI8|rcsb pdb:3KRM|rcsb pdb:6QEY|reactome:R-HSA-428359|reactome:R-HSA-5687128|dip:DIP-38139N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Ps/PWWYr0WpYcx3G/AOiQEj+vc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y2Q3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053767|uniprotkb:Q7Z520|uniprotkb:Q6P4H0|uniprotkb:Q9P1S4|uniprotkb:B4DIH1|uniprotkb:B4DSY2|ensembl:ENSP00000351181	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstk1_human(display_long)|uniprotkb:Glutathione S-transferase subunit 13(gene name synonym)|uniprotkb:GST 13-13(gene name synonym)|uniprotkb:GST class-kappa(gene name synonym)|uniprotkb:GSTK1-1(gene name synonym)|uniprotkb:GSTK1(gene name)|psi-mi:GSTK1(display_short)|uniprotkb:HDCMD47P(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001137151.1|refseq:NP_001137152.1|refseq:NP_001137153.1|refseq:NP_057001.1|ensembl:ENSG00000197448(gene)|ensembl:ENST00000358406(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001853(DSBA oxidoreductase)|interpro:IPR014440(HCCA isomerase/glutathione S-transferase kappa)|interpro:IPR036249|interpro:IPR044088|rcsb pdb:1YZX|rcsb pdb:3RPN|rcsb pdb:3RPP|reactome:R-HSA-156590|reactome:R-HSA-9033241|dip:DIP-46924N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aTjqqss32Y4bcsXg6gYlazahVCw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35527	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356382|uniprotkb:O00109|uniprotkb:Q0IJ47|uniprotkb:Q14665|ensembl:ENSP00000246662	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c9_human(display_long)|uniprotkb:KRT9(gene name)|psi-mi:KRT9(display_short)|uniprotkb:Keratin-9(gene name synonym)|uniprotkb:Cytokeratin-9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000217.2|ensembl:ENSG00000171403(gene)|ensembl:ENST00000246662(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0043588"(skin development)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P35527|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m4EXfxbK2t1/EmI04YODKTJ02Zw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P47756	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353595|uniprotkb:Q5U0L4|uniprotkb:Q8TB49|uniprotkb:Q9NUC4|uniprotkb:Q32Q68|ensembl:ENSP00000364284|ensembl:ENSP00000501528	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:capzb_human(display_long)|uniprotkb:CAPZB(gene name)|psi-mi:CAPZB(display_short)|uniprotkb:CapZ beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001193469.1|refseq:NP_004921.1|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|mint:P47756|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-9013405|reactome:R-HSA-9035034|reactome:R-HSA-9662360|reactome:R-HSA-983231|ensembl:ENSG00000077549(gene)|ensembl:ENST00000375142(transcript)|ensembl:ENST00000674432(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030863"(cortical cytoskeleton)|refseq:NP_001269091.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qRXsrB2fLT1DMVIVRWKFYe4Aln49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42766	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356819|uniprotkb:Q4VBY5|uniprotkb:Q9BYF4|uniprotkb:Q5JTN5|uniprotkb:Q6IBC7|uniprotkb:Q96QJ7|uniprotkb:A8K4V7|ensembl:ENSP00000259469	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl35_human(display_long)|uniprotkb:RPL35(gene name)|psi-mi:RPL35(display_short)|uniprotkb:Large ribosomal subunit protein uL29(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009140.1|ensembl:ENSG00000136942(gene)|ensembl:ENST00000348462(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001854(Ribosomal protein L29)|interpro:IPR018254|interpro:IPR036049|mint:P42766|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jhzt7gCff2vdUb1Ff/VTBF698Pg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6UY14	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742002|uniprotkb:Q5T5F7|uniprotkb:Q6IPM6|uniprotkb:Q8N643|uniprotkb:Q9HBS6|ensembl:ENSP00000271643|ensembl:ENSP00000358034|uniprotkb:B2RTT0|uniprotkb:F8WAD0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atl4_human(display_long)|uniprotkb:Thrombospondin repeat-containing protein 1(gene name synonym)|uniprotkb:ADAMTSL4(gene name)|psi-mi:ADAMTSL4(display_short)|uniprotkb:TSRC1(gene name synonym)|uniprotkb:PP1396(orf name)|uniprotkb:UNQ2803/PRO34012(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061905.2|refseq:NP_079284.2|ensembl:ENSG00000143382(gene)|ensembl:ENST00000271643(transcript)|ensembl:ENST00000369038(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006915"(apoptotic process)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR036383|mint:Q6UY14|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005576"(extracellular region)|refseq:NP_001275536.1|refseq:NP_001275537.1|refseq:XP_011507950.1|refseq:XP_016856995.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HIXY8OQopS51RVemJo0GTj8V0WQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-749627|uniprotkb:Q53ZD6|uniprotkb:E1P5N4|ensembl:ENSP00000217402	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:chm4b_human(display_long)|uniprotkb:Chromatin-modifying protein 4b(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 32-2(gene name synonym)|uniprotkb:SNF7-2(gene name synonym)|uniprotkb:SNF7 homolog associated with Alix 1(gene name synonym)|uniprotkb:CHMP4B(gene name)|psi-mi:CHMP4B(display_short)|uniprotkb:C20orf178(gene name synonym)|uniprotkb:SHAX1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_789782.1|dip:DIP-29924N|ensembl:ENSG00000101421(gene)|ensembl:ENST00000217402(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016236"(macroautophagy)|go:"GO:0030117"(membrane coat)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046755"(viral budding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051258"(protein polymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090148"(membrane fission)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR005024(Snf7)|mint:Q9H444|rcsb pdb:3C3Q|rcsb pdb:3UM3|rcsb pdb:4ABM|rcsb pdb:5MK2|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0010824"(regulation of centrosome duplication)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hbJvirD5+L7fxzOoWbiP1ky6c9M9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14866	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719024|uniprotkb:Q9H3P3|uniprotkb:A6ND69|uniprotkb:A6NIT8|ensembl:ENSP00000221419|ensembl:ENSP00000489021	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpl_human(display_long)|uniprotkb:HNRPL(gene name synonym)|uniprotkb:HNRNPL(gene name)|psi-mi:HNRNPL(display_short)|uniprotkb:P/OKcl.14(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001005335.1|refseq:NP_001524.2|refseq:XP_011525191.1|ensembl:ENSG00000282947(gene)|ensembl:ENST00000221419(transcript)|ensembl:ENST00000634753(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097157"(pre-mRNA intronic binding)|ensembl:ENSG00000104824(gene)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979|mint:P14866|rcsb pdb:3R27|rcsb pdb:3TO8|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:1990904"(ribonucleoprotein complex)|dip:DIP-36355N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vOfznm03e6Ottg6BptYHmR9qJEc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33992	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8TEM1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372826|uniprotkb:A6NN56|uniprotkb:O94980|uniprotkb:Q6NXG6|uniprotkb:Q8NBJ1|uniprotkb:Q9H6C8|uniprotkb:Q9UFP3|ensembl:ENSP00000254508	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:po210_human(display_long)|uniprotkb:KIAA0906(gene name synonym)|uniprotkb:NUP210(gene name)|psi-mi:NUP210(display_short)|uniprotkb:PSEC0245(orf name)|uniprotkb:Nuclear envelope pore membrane protein POM 210(gene name synonym)|uniprotkb:Pore membrane protein of 210 kDa(gene name synonym)|uniprotkb:Nucleoporin Nup210(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-9610379|refseq:NP_079199.2|ensembl:ENSG00000132182(gene)|ensembl:ENST00000254508(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003343(Bacterial Ig-like, group 2)|interpro:IPR008964(Invasin/intimin cell-adhesion)|mint:Q8TEM1|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:udIemFThWYk0VC21Ml4EDDQWXlg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49736	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69905	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714680|uniprotkb:P01922|ensembl:ENSP00000251595|ensembl:ENSP00000322421|uniprotkb:Q3MIF5|uniprotkb:Q96KF1|uniprotkb:Q9NYR7|uniprotkb:Q1HDT5|uniprotkb:Q53F97|uniprotkb:Q9UCM0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hba_human(display_long)|uniprotkb:Hemoglobin alpha chain(gene name synonym)|uniprotkb:Alpha-globin(gene name synonym)|uniprotkb:HBA1(gene name)|psi-mi:HBA1(display_short)|uniprotkb:HBA2(gene name)|psi-mi:HBA2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000188536(gene)|ensembl:ENSG00000206172(gene)|ensembl:ENST00000251595(transcript)|ensembl:ENST00000320868(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015671"(oxygen transport)|go:"GO:0016020"(membrane)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002339(Haemoglobin, pi)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|mint:P69905|rcsb pdb:1A00|rcsb pdb:1A01|rcsb pdb:1A0U|rcsb pdb:1A0Z|rcsb pdb:1A3N|rcsb pdb:1A3O|rcsb pdb:1A9W|rcsb pdb:1ABW|rcsb pdb:1ABY|rcsb pdb:1AJ9|rcsb pdb:1B86|rcsb pdb:1BAB|rcsb pdb:1BBB|rcsb pdb:1BIJ|rcsb pdb:1BUW|rcsb pdb:1BZ0|rcsb pdb:1BZ1|rcsb pdb:1BZZ|rcsb pdb:1C7B|rcsb pdb:1C7C|rcsb pdb:1C7D|rcsb pdb:1CLS|rcsb pdb:1CMY|rcsb pdb:1COH|rcsb pdb:1DKE|rcsb pdb:1DXT|rcsb pdb:1DXU|rcsb pdb:1DXV|rcsb pdb:1FDH|rcsb pdb:1FN3|rcsb pdb:1G9V|rcsb pdb:1YVQ|rcsb pdb:1YVT|rcsb pdb:1YZI|rcsb pdb:1Z8U|rcsb pdb:2D5Z|rcsb pdb:2D60|rcsb pdb:2DN1|rcsb pdb:2DN2|rcsb pdb:2DN3|rcsb pdb:2DXM|rcsb pdb:2H35|rcsb pdb:2HBC|rcsb pdb:2HBD|rcsb pdb:2HBE|rcsb pdb:2HBF|rcsb pdb:2HBS|rcsb pdb:2HCO|rcsb pdb:2HHB|rcsb pdb:2HHD|rcsb pdb:2HHE|rcsb pdb:2M6Z|rcsb pdb:2W6V|rcsb pdb:2W72|rcsb pdb:2YRS|rcsb pdb:3B75|rcsb pdb:3D17|rcsb pdb:3D7O|rcsb pdb:3DUT|rcsb pdb:3HHB|rcsb pdb:3HXN|rcsb pdb:3IA3|rcsb pdb:3IC0|rcsb pdb:3IC2|rcsb pdb:3KMF|rcsb pdb:3NL7|rcsb pdb:3NMM|rcsb pdb:3ODQ|rcsb pdb:3ONZ|rcsb pdb:3OO4|rcsb pdb:3OO5|rcsb pdb:3OVU|rcsb pdb:3P5Q|rcsb pdb:3QJB|rcsb pdb:3QJC|rcsb pdb:3QJD|rcsb pdb:3QJE|rcsb pdb:3R5I|rcsb pdb:3S48|rcsb pdb:3S65|rcsb pdb:3S66|rcsb pdb:3SZK|rcsb pdb:3WCP|rcsb pdb:3WHM|rcsb pdb:4FC3|rcsb pdb:4HHB|rcsb pdb:4IJ2|rcsb pdb:4L7Y|rcsb pdb:4M4A|rcsb pdb:4M4B|rcsb pdb:4MQC|rcsb pdb:4MQG|rcsb pdb:4MQH|rcsb pdb:4MQI|rcsb pdb:4MQJ|rcsb pdb:4MQK|rcsb pdb:4X0L|rcsb pdb:4XS0|rcsb pdb:5E29|rcsb pdb:5E6E|rcsb pdb:5E83|rcsb pdb:5EE4|rcsb pdb:5HU6|rcsb pdb:5HY8|rcsb pdb:5JDO|rcsb pdb:5KDQ|rcsb pdb:5KSI|rcsb pdb:5KSJ|rcsb pdb:5NI1|rcsb pdb:5SW7|rcsb pdb:5U3I|rcsb pdb:5UCU|rcsb pdb:5UFJ|rcsb pdb:5URC|rcsb pdb:5VMM|rcsb pdb:5WOG|rcsb pdb:5WOH|rcsb pdb:5X2R|rcsb pdb:5X2S|rcsb pdb:5X2T|rcsb pdb:5X2U|rcsb pdb:6BB5|rcsb pdb:6BNR|rcsb pdb:6BWP|rcsb pdb:6BWU|rcsb pdb:6DI4|rcsb pdb:6HAL|rcsb pdb:6HBW|rcsb pdb:6HK2|rcsb pdb:6KA9|rcsb pdb:6KAE|rcsb pdb:6KAH|rcsb pdb:6KAI|rcsb pdb:6KAO|rcsb pdb:6KAP|rcsb pdb:6KAQ|rcsb pdb:6KAR|rcsb pdb:6KAS|rcsb pdb:6KAT|rcsb pdb:4N7N|rcsb pdb:6KAU|rcsb pdb:4N7O|rcsb pdb:4N7P|rcsb pdb:6KAV|rcsb pdb:4N8T|rcsb pdb:6KYE|rcsb pdb:6L5V|rcsb pdb:6L5W|rcsb pdb:6L5X|rcsb pdb:6L5Y|rcsb pdb:6LCW|rcsb pdb:6LCX|rcsb pdb:4NI0|rcsb pdb:4NI1|rcsb pdb:4ROL|rcsb pdb:4ROM|rcsb pdb:4WJG|rcsb pdb:6NBC|rcsb pdb:6NBD|rcsb pdb:6NQ5|rcsb pdb:6TB2|rcsb pdb:6XD9|rcsb pdb:6XDT|rcsb pdb:6XE7|rcsb pdb:7AET|rcsb pdb:7AEV|rcsb pdb:7JJQ|rcsb pdb:7JXZ|rcsb pdb:7JY0|rcsb pdb:7JY1|rcsb pdb:7JY3|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-2168880|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:7AEU|refseq:NP_000508.1|refseq:NP_000549.1|rcsb pdb:1GBU|rcsb pdb:1GBV|rcsb pdb:1GLI|rcsb pdb:1GZX|rcsb pdb:1HAB|rcsb pdb:1HAC|rcsb pdb:1HBA|rcsb pdb:1HBB|rcsb pdb:1HBS|rcsb pdb:1HCO|rcsb pdb:1HDB|rcsb pdb:1HGA|rcsb pdb:1HGB|rcsb pdb:1HGC|rcsb pdb:1HHO|rcsb pdb:1IRD|rcsb pdb:1J3Y|rcsb pdb:1J3Z|rcsb pdb:1J40|rcsb pdb:1J41|rcsb pdb:1J7S|rcsb pdb:1J7W|rcsb pdb:1J7Y|rcsb pdb:1JY7|rcsb pdb:1K0Y|rcsb pdb:1K1K|rcsb pdb:1KD2|rcsb pdb:1LFL|rcsb pdb:1LFQ|rcsb pdb:1LFT|rcsb pdb:1LFV|rcsb pdb:1LFY|rcsb pdb:1LFZ|rcsb pdb:1LJW|rcsb pdb:1M9P|rcsb pdb:1MKO|rcsb pdb:1NEJ|rcsb pdb:1NIH|rcsb pdb:1NQP|rcsb pdb:1O1I|rcsb pdb:1O1J|rcsb pdb:1O1K|rcsb pdb:1O1L|rcsb pdb:1O1M|rcsb pdb:1O1N|rcsb pdb:1O1O|rcsb pdb:1O1P|rcsb pdb:1QI8|rcsb pdb:1QSH|rcsb pdb:1QSI|rcsb pdb:1QXD|rcsb pdb:1QXE|rcsb pdb:1R1X|rcsb pdb:1R1Y|rcsb pdb:1RPS|rcsb pdb:1RQ3|rcsb pdb:1RQ4|rcsb pdb:1RQA|rcsb pdb:1RVW|rcsb pdb:1SDK|rcsb pdb:1SDL|rcsb pdb:1SHR|rcsb pdb:1SI4|rcsb pdb:1THB|rcsb pdb:1UIW|rcsb pdb:1VWT|rcsb pdb:1XXT|rcsb pdb:1XY0|rcsb pdb:1XYE|rcsb pdb:1XZ2|rcsb pdb:1XZ4|rcsb pdb:1XZ5|rcsb pdb:1XZ7|rcsb pdb:1XZU|rcsb pdb:1XZV|rcsb pdb:1Y01|rcsb pdb:1Y09|rcsb pdb:1Y0A|rcsb pdb:1Y0C|rcsb pdb:1Y0D|rcsb pdb:1Y0T|rcsb pdb:1Y0W|rcsb pdb:1Y22|rcsb pdb:1Y2Z|rcsb pdb:1Y31|rcsb pdb:1Y35|rcsb pdb:1Y45|rcsb pdb:1Y46|rcsb pdb:1Y4B|rcsb pdb:1Y4F|rcsb pdb:1Y4G|rcsb pdb:1Y4P|rcsb pdb:1Y4Q|rcsb pdb:1Y4R|rcsb pdb:1Y4V|rcsb pdb:1Y5F|rcsb pdb:1Y5J|rcsb pdb:1Y5K|rcsb pdb:1Y7C|rcsb pdb:1Y7D|rcsb pdb:1Y7G|rcsb pdb:1Y7Z|rcsb pdb:1Y83|rcsb pdb:1Y85|rcsb pdb:1Y8W|rcsb pdb:1YDZ|rcsb pdb:1YE0|rcsb pdb:1YE1|rcsb pdb:1YE2|rcsb pdb:1YEN|rcsb pdb:1YEO|rcsb pdb:1YEQ|rcsb pdb:1YEU|rcsb pdb:1YEV|rcsb pdb:1YFF|rcsb pdb:1YG5|rcsb pdb:1YGD|rcsb pdb:1YGF|rcsb pdb:1YH9|rcsb pdb:1YHE|rcsb pdb:1YHR|rcsb pdb:1YIE|rcsb pdb:1YIH|dip:DIP-35199N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M4o0FF1DIrouBdyFXr4UtAlcjZw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15056	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748492|uniprotkb:A8K3R1|uniprotkb:D3DXF6|uniprotkb:D3DXF8|ensembl:ENSP00000265753	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4h_human(display_long)|uniprotkb:Williams-Beuren syndrome chromosomal region 1 protein(gene name synonym)|uniprotkb:EIF4H(gene name)|psi-mi:EIF4H(display_short)|uniprotkb:WBSCR1(gene name synonym)|uniprotkb:KIAA0038(gene name synonym)|uniprotkb:WSCR1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_071496.1|refseq:NP_114381.1|ensembl:ENSG00000106682(gene)|ensembl:ENST00000265753(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0019953"(sexual reproduction)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034057"(RNA strand-exchange activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048589"(developmental growth)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034229|interpro:IPR035979|mint:Q15056|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dNPoAzwFD5lFwCMnRl0cbXM3j8s9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5SSJ5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2880687|ensembl:ENSP00000312625|ensembl:ENSP00000403039|uniprotkb:Q5SWC6|uniprotkb:Q6PIM9|uniprotkb:B3KMZ8|uniprotkb:A8K5D7|uniprotkb:Q8NDF0|uniprotkb:Q05BI0|uniprotkb:B4E210|uniprotkb:A6NI71|uniprotkb:Q9UHY0|uniprotkb:Q5SSJ6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hp1b3_human(display_long)|uniprotkb:HP1BP3(gene name)|psi-mi:HP1BP3(display_short)|uniprotkb:Protein HP1-BP74(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000127483(gene)|ensembl:ENST00000312239(transcript)|ensembl:ENST00000438032(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097298"(regulation of nucleus size)|interpro:IPR005818(Histone H1/H5)|interpro:IPR033061|interpro:IPR036388|interpro:IPR036390|mint:Q5SSJ5|rcsb pdb:2RQP|go:"GO:0005694"(chromosome)|refseq:XP_016856882.1|refseq:XP_016856883.1|refseq:XP_011539834.1|refseq:XP_011539835.1|refseq:XP_011539836.1|refseq:NP_057371.2|refseq:XP_005245932.1|refseq:XP_005245933.1|refseq:XP_005245934.1|refseq:XP_005245935.1|refseq:XP_005245936.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kLFithZZv+Qn9YLElEnX81awKDw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62857	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353027|ensembl:ENSP00000472469|uniprotkb:P25112	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs28_human(display_long)|uniprotkb:RPS28(gene name)|psi-mi:RPS28(display_short)|uniprotkb:Small ribosomal subunit protein eS28(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	mint:P62857|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|ensembl:ENSG00000233927(gene)|ensembl:ENST00000600659(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR000289(Ribosomal protein S28e)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028626|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZM7|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001022.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G4t8mOlzIiHEOXu+uS+AfySWAnM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53990	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945994|intact:EBI-4324656|uniprotkb:A8KAH5|uniprotkb:Q9BQ81|uniprotkb:Q9BWN2|uniprotkb:Q3SYM4|uniprotkb:J3QLU7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ist1_human(display_long)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Putative MAPK-activating protein PM28(gene name synonym)|uniprotkb:KIAA0174(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055576.2|refseq:NP_001257904.1|refseq:NP_001257906.1|refseq:NP_001257905.1|refseq:NP_001257907.1|mint:P53990|dip:DIP-42546N|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0009838"(abscission)|go:"GO:0015031"(protein transport)|go:"GO:0019076"(viral release from host cell)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046745"(viral capsid secondary envelopment)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:0090543"(Flemming body)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3FRR|rcsb pdb:3FRS|rcsb pdb:3JC1|rcsb pdb:4U7E|rcsb pdb:4U7I|rcsb pdb:4U7Y|rcsb pdb:4WZX|rcsb pdb:6E8G|rcsb pdb:6TZ4|rcsb pdb:6TZ5|rcsb pdb:6TZA|reactome:R-HSA-6798695|reactome:R-HSA-9668328	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RbWwKZ+sftO2x3UkFz8zAxVi2CU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99729	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044873|uniprotkb:Q04150|uniprotkb:Q8N7U3|uniprotkb:Q9BQ99|intact:EBI-2339961|uniprotkb:B3KNN5|uniprotkb:D3DWP7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roaa_human(display_long)|uniprotkb:HNRPAB(gene name synonym)|uniprotkb:APOBEC1-binding protein 1(gene name synonym)|uniprotkb:HNRNPAB(gene name)|psi-mi:HNRNPAB(display_short)|uniprotkb:ABBP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004490.2|refseq:NP_112556.2|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR034846|interpro:IPR035979|rcsb pdb:3S7R|mint:Q99729|dip:DIP-50394N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NzusDKSvcoVb90LNvXpaMAvg0Oo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04406	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04083	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354007|ensembl:ENSP00000257497|ensembl:ENSP00000366109|uniprotkb:B5BU38	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anxa1_human(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:LPC1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000691.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|ensembl:ENSG00000135046(gene)|ensembl:ENST00000257497(transcript)|ensembl:ENST00000376911(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|refseq:XP_011516911.1|dip:DIP-32875N|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P04083|rcsb pdb:1AIN|rcsb pdb:1BO9|rcsb pdb:1QLS|rcsb pdb:5VFW|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-445355|reactome:R-HSA-6785807|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QKmqz+UsAof35B/so2qKLQjn2v09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NR56	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2805004|uniprotkb:O43797|uniprotkb:O43311|uniprotkb:Q86UV8|uniprotkb:Q96P92|uniprotkb:Q96RE3|uniprotkb:E9PBW7|uniprotkb:Q86UV9|ensembl:ENSP00000282486|ensembl:ENSP00000418108	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mbnl1_human(display_long)|uniprotkb:EXP(gene name synonym)|uniprotkb:KIAA0428(gene name synonym)|uniprotkb:MBNL(gene name synonym)|uniprotkb:Triplet-expansion RNA-binding protein(gene name synonym)|uniprotkb:MBNL1(gene name)|psi-mi:MBNL1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011511149.1|refseq:XP_011511151.1|refseq:NP_001300986.1|refseq:NP_066368.2|refseq:NP_997175.1|refseq:NP_997176.1|refseq:NP_997177.1|refseq:NP_997178.1|refseq:NP_997179.1|refseq:NP_997180.1|refseq:XP_005247523.1|refseq:XP_005247528.1|ensembl:ENSP00000282486|ensembl:ENST00000324196|ensembl:ENSP00000319374|ensembl:ENST00000324210|ensembl:ENSP00000319429|ensembl:ENST00000355460|ensembl:ENSP00000347637|ensembl:ENST00000357472|ensembl:ENSP00000350064|ensembl:ENSP00000418108|ensembl:ENST00000465907|ensembl:ENSP00000417630|ensembl:ENST00000485509|ensembl:ENSP00000418876|ensembl:ENST00000485910|ensembl:ENSP00000418427|ensembl:ENST00000492948|ensembl:ENSP00000420103|ensembl:ENST00000545754|ensembl:ENSP00000437491|interpro:IPR000571(Zinc finger, CCCH-type)|mint:Q9NR56|rcsb pdb:3D2N|rcsb pdb:3D2Q|rcsb pdb:3D2S|rcsb pdb:5U6H|rcsb pdb:5U6L|rcsb pdb:5U9B|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000152601(gene)|ensembl:ENST00000282486(transcript)|ensembl:ENST00000463374(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045445"(myoblast differentiation)|refseq:XP_016861914.1|refseq:XP_016861915.1|refseq:XP_016861916.1|refseq:XP_016861917.1|refseq:XP_016861918.1|refseq:XP_016861919.1|refseq:XP_016861920.1|refseq:XP_016861925.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uvyDik76f41mvxO2j/dUD6mKMOk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15357	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08727	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-742756|uniprotkb:Q5XG83|uniprotkb:Q6NW33|uniprotkb:Q7L5M9|uniprotkb:Q96A53|uniprotkb:Q96FV1|uniprotkb:Q9BYF9|uniprotkb:Q9P1Y4|uniprotkb:B2R874|ensembl:ENSP00000355124	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c19_human(display_long)|uniprotkb:Cytokeratin-19(gene name synonym)|uniprotkb:Keratin-19(gene name synonym)|uniprotkb:KRT19(gene name)|psi-mi:KRT19(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002267.2|ensembl:ENSG00000171345(gene)|ensembl:ENST00000361566(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990357"(terminal web)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P08727|reactome:R-HSA-6805567|reactome:R-HSA-6809371|dip:DIP-35655N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fqsG2nghpcmTtI39LiYVLNYuFIA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00610	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08648	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q04637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53680	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297662|ensembl:ENSP00000263270|uniprotkb:O75977|uniprotkb:Q6PK67|uniprotkb:B2R4Z4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2s1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit sigma(gene name synonym)|uniprotkb:AP2S1(gene name)|psi-mi:AP2S1(display_short)|uniprotkb:Sigma2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 17 kDa protein(gene name synonym)|uniprotkb:HA2 17 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP17(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP17(gene name synonym)|uniprotkb:AP17(gene name synonym)|uniprotkb:CLAPS2(gene name synonym)|uniprotkb:Clathrin assembly protein 2 sigma small chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit sigma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000042753(gene)|ensembl:ENST00000263270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR027156|rcsb pdb:6URI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004060.2|refseq:NP_067586.1|refseq:NP_001288005.1|refseq:NP_001288007.1|refseq:NP_001288010.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AJxHeeoCpwPxjsRcAQkiAGaC9k09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04792	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09211	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353467|uniprotkb:O00460|uniprotkb:Q15690|ensembl:ENSP00000381607|uniprotkb:Q5TZY3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstp1_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short)|uniprotkb:GST3(gene name synonym)|uniprotkb:FAEES3(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:GSTP1-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000843.1|ensembl:ENSG00000084207(gene)|go:"GO:0000302"(response to reactive oxygen species)|ensembl:ENST00000398606(transcript)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0035732"(nitric oxide storage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P09211|rcsb pdb:10GS|rcsb pdb:11GS|rcsb pdb:12GS|rcsb pdb:13GS|rcsb pdb:14GS|rcsb pdb:16GS|rcsb pdb:17GS|rcsb pdb:18GS|rcsb pdb:19GS|rcsb pdb:1AQV|rcsb pdb:1AQW|rcsb pdb:1AQX|rcsb pdb:1EOG|rcsb pdb:1EOH|rcsb pdb:1GSS|rcsb pdb:1KBN|rcsb pdb:1LBK|rcsb pdb:1MD3|rcsb pdb:1MD4|rcsb pdb:1PGT|rcsb pdb:1PX6|rcsb pdb:1PX7|rcsb pdb:1ZGN|rcsb pdb:20GS|rcsb pdb:22GS|rcsb pdb:2A2R|rcsb pdb:2A2S|rcsb pdb:2GSS|rcsb pdb:2J9H|rcsb pdb:2PGT|rcsb pdb:3CSH|rcsb pdb:3CSI|rcsb pdb:3CSJ|rcsb pdb:3DD3|rcsb pdb:3DGQ|rcsb pdb:3GSS|rcsb pdb:3GUS|rcsb pdb:3HJM|rcsb pdb:3HJO|rcsb pdb:3HKR|rcsb pdb:3IE3|rcsb pdb:3KM6|rcsb pdb:3KMN|rcsb pdb:3KMO|rcsb pdb:3N9J|rcsb pdb:3PGT|rcsb pdb:4GSS|rcsb pdb:4PGT|rcsb pdb:5DAK|rcsb pdb:5DAL|rcsb pdb:5DCG|rcsb pdb:5DDL|rcsb pdb:5DJL|rcsb pdb:5DJM|rcsb pdb:5GSS|rcsb pdb:5J41|rcsb pdb:5JCW|rcsb pdb:5L6X|rcsb pdb:5X79|rcsb pdb:6AP9|rcsb pdb:6GSS|rcsb pdb:6LLX|rcsb pdb:6Y1E|rcsb pdb:7GSS|rcsb pdb:8GSS|rcsb pdb:9GSS|reactome:R-HSA-156590|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxqbNusNIvkTg3Cq+7pmygP/EIA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60610	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99661	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642317|uniprotkb:Q96C18|uniprotkb:Q96HB8|uniprotkb:Q9BWV8|uniprotkb:Q5JR88|uniprotkb:B3ITR9|uniprotkb:Q6ICU1|ensembl:ENSP00000361298	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kif2c_human(display_long)|uniprotkb:KNSL6(gene name synonym)|uniprotkb:KIF2C(gene name)|psi-mi:KIF2C(display_short)|uniprotkb:Mitotic centromere-associated kinesin(gene name synonym)|uniprotkb:Kinesin-like protein 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006836.2|refseq:NP_001284584.1|refseq:NP_001284585.1|refseq:NP_001284586.1|ensembl:ENSG00000142945(gene)|ensembl:ENST00000372224(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q99661|rcsb pdb:2HEH|rcsb pdb:4UBF|rcsb pdb:4Y05|rcsb pdb:5MIO|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XKQr6i+9Xtdfir6V1C8PByAIg1c9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08945	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353771|uniprotkb:Q5BJG8|ensembl:ENSP00000278412	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ssrp1_human(display_long)|uniprotkb:SSRP1(gene name)|psi-mi:SSRP1(display_short)|uniprotkb:FACT80(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SSRP1(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex 80 kDa subunit(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 80 kDa subunit(gene name synonym)|uniprotkb:Structure-specific recognition protein 1(gene name synonym)|uniprotkb:Recombination signal sequence recognition protein 1(gene name synonym)|uniprotkb:T160(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003137.1|ensembl:ENSG00000149136(gene)|ensembl:ENST00000278412(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035101"(FACT complex)|go:"GO:0042393"(histone binding)|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000969(Structure-specific recognition protein)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR024954|interpro:IPR035417|interpro:IPR036910|interpro:IPR038167|mint:Q08945|rcsb pdb:4IFS|rcsb pdb:5UMR|rcsb pdb:5UMS|rcsb pdb:5VWE|rcsb pdb:6L1E|rcsb pdb:6L1R|rcsb pdb:6L34|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|dip:DIP-169N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WmdGVZadHdcS6Nk9SI41xKm+OrU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62805	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302023|ensembl:ENSP00000244537|ensembl:ENSP00000347168|ensembl:ENSP00000350767|ensembl:ENSP00000366974|ensembl:ENSP00000366956|ensembl:ENSP00000462667|ensembl:ENSP00000367034|ensembl:ENSP00000478519|ensembl:ENSP00000478786|ensembl:ENSP00000443017|ensembl:ENSP00000462355|ensembl:ENSP00000479106|ensembl:ENSP00000479461|uniprotkb:A2VCL0|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6DRA9|uniprotkb:Q6FGB8|uniprotkb:Q6NWP7|ensembl:ENSP00000479794|ensembl:ENSP00000480960|ensembl:ENSP00000481343|ensembl:ENSP00000481486|ensembl:ENSP00000481507|ensembl:ENSP00000482412|ensembl:ENSP00000484789|ensembl:ENSP00000489319|ensembl:ENSP00000489567	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h4_human(display_long)|uniprotkb:H4-16(gene name)|psi-mi:H4-16(display_short)|uniprotkb:H4C1(gene name)|psi-mi:H4C1(display_short)|uniprotkb:H4C11(gene name)|psi-mi:H4C11(display_short)|uniprotkb:H4C12(gene name)|psi-mi:H4C12(display_short)|uniprotkb:H4C13(gene name)|psi-mi:H4C13(display_short)|uniprotkb:H4C14(gene name)|psi-mi:H4C14(display_short)|uniprotkb:H4C15(gene name)|psi-mi:H4C15(display_short)|uniprotkb:H4C2(gene name)|psi-mi:H4C2(display_short)|uniprotkb:H4C3(gene name)|psi-mi:H4C3(display_short)|uniprotkb:H4C4(gene name)|psi-mi:H4C4(display_short)|uniprotkb:H4C5(gene name)|psi-mi:H4C5(display_short)|uniprotkb:H4C6(gene name)|psi-mi:H4C6(display_short)|uniprotkb:H4C8(gene name)|psi-mi:H4C8(display_short)|uniprotkb:H4C9(gene name)|psi-mi:H4C9(display_short)|uniprotkb:H4/A(gene name synonym)|uniprotkb:H4/B(gene name synonym)|uniprotkb:H4/C(gene name synonym)|uniprotkb:H4/D(gene name synonym)|uniprotkb:H4/E(gene name synonym)|uniprotkb:H4/G(gene name synonym)|uniprotkb:H4/H(gene name synonym)|uniprotkb:H4/I(gene name synonym)|uniprotkb:H4/J(gene name synonym)|uniprotkb:H4/K(gene name synonym)|uniprotkb:H4/M(gene name synonym)|uniprotkb:H4/N(gene name synonym)|uniprotkb:H4/O(gene name synonym)|uniprotkb:H4F2(gene name synonym)|uniprotkb:H4FA(gene name synonym)|uniprotkb:H4FB(gene name synonym)|uniprotkb:H4FC(gene name synonym)|uniprotkb:H4FD(gene name synonym)|uniprotkb:H4FE(gene name synonym)|uniprotkb:H4FG(gene name synonym)|uniprotkb:H4FH(gene name synonym)|uniprotkb:H4FI(gene name synonym)|uniprotkb:H4FJ(gene name synonym)|uniprotkb:H4FK(gene name synonym)|uniprotkb:H4FM(gene name synonym)|uniprotkb:H4FN(gene name synonym)|uniprotkb:H4FO(gene name synonym)|uniprotkb:HIST1H4A(gene name synonym)|uniprotkb:HIST1H4B(gene name synonym)|uniprotkb:HIST1H4C(gene name synonym)|uniprotkb:HIST1H4D(gene name synonym)|uniprotkb:HIST1H4E(gene name synonym)|uniprotkb:HIST1H4F(gene name synonym)|uniprotkb:HIST1H4H(gene name synonym)|uniprotkb:HIST1H4I(gene name synonym)|uniprotkb:HIST1H4J(gene name synonym)|uniprotkb:HIST1H4K(gene name synonym)|uniprotkb:HIST1H4L(gene name synonym)|uniprotkb:HIST2H4(gene name synonym)|uniprotkb:HIST2H4A(gene name synonym)|uniprotkb:HIST2H4B(gene name synonym)|uniprotkb:HIST4H4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000197061(gene)|ensembl:ENSG00000276180(gene)|ensembl:ENSG00000197238(gene)|ensembl:ENSG00000276966(gene)|ensembl:ENSG00000277157(gene)|ensembl:ENSG00000270276(gene)|ensembl:ENSG00000197837(gene)|ensembl:ENSG00000270882(gene)|ensembl:ENSG00000278637(gene)|ensembl:ENSG00000273542(gene)|ensembl:ENSG00000274618(gene)|ensembl:ENSG00000278705(gene)|ensembl:ENSG00000275126(gene)|ensembl:ENSG00000158406(gene)|dip:DIP-33079N|ensembl:ENST00000244537(transcript)|ensembl:ENST00000355057(transcript)|ensembl:ENST00000358064(transcript)|ensembl:ENST00000377727(transcript)|ensembl:ENST00000377745(transcript)|ensembl:ENST00000377803(transcript)|ensembl:ENST00000539745(transcript)|ensembl:ENST00000578186(transcript)|ensembl:ENST00000579512(transcript)|ensembl:ENST00000611927(transcript)|ensembl:ENST00000612061(transcript)|ensembl:ENST00000613412(transcript)|ensembl:ENST00000614247(transcript)|ensembl:ENST00000614272(transcript)|ensembl:ENST00000615164(transcript)|ensembl:ENST00000615353(transcript)|ensembl:ENST00000617569(transcript)|ensembl:ENST00000618193(transcript)|ensembl:ENST00000618305(transcript)|ensembl:ENST00000621520(transcript)|ensembl:ENST00000634560(transcript)|ensembl:ENST00000634956(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0005576"(extracellular region)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AYW|rcsb pdb:3AZJ|rcsb pdb:3AZK|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:3F9W|rcsb pdb:3F9X|rcsb pdb:3F9Y|rcsb pdb:3F9Z|rcsb pdb:3IJ1|rcsb pdb:3JPX|rcsb pdb:3NQJ|rcsb pdb:3NQU|rcsb pdb:3O36|rcsb pdb:3QBY|rcsb pdb:3QZS|rcsb pdb:3QZT|rcsb pdb:3QZV|rcsb pdb:3R45|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3WTP|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:4GQB|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:4M38|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4QUT|rcsb pdb:4QUU|rcsb pdb:4QYD|rcsb pdb:4U9W|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4YY6|rcsb pdb:4YYD|rcsb pdb:4YYG|rcsb pdb:4YYH|rcsb pdb:4YYI|rcsb pdb:4YYJ|rcsb pdb:4YYK|rcsb pdb:4YYM|rcsb pdb:4YYN|rcsb pdb:4Z2M|rcsb pdb:4Z5T|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5AY8|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B2J|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5B40|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5CPI|interpro:IPR019809|interpro:IPR035425|mint:P62805|rcsb pdb:1ZKK|rcsb pdb:2BQZ|rcsb pdb:2CV5|rcsb pdb:2IG0|rcsb pdb:2KWN|rcsb pdb:2KWO|rcsb pdb:2LVM|rcsb pdb:2QQS|rcsb pdb:2RJE|rcsb pdb:2RNY|interpro:IPR009072(Histone-fold)|rcsb pdb:2RS9|rcsb pdb:3A6N|rcsb pdb:3AFA|rcsb pdb:3AN2|rcsb pdb:3AV1|rcsb pdb:3AV2|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5GXQ|rcsb pdb:5JA4|rcsb pdb:5JRG|rcsb pdb:5KDM|rcsb pdb:5TEG|rcsb pdb:5X7X|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5YE3|rcsb pdb:5YE4|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:5ZBX|rcsb pdb:5ZGC|rcsb pdb:5CPJ|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:5CPK|rcsb pdb:6A5P|rcsb pdb:5FA5|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6ACP|rcsb pdb:6BUZ|rcsb pdb:6C0W|rcsb pdb:6E0C|rcsb pdb:6E0P|rcsb pdb:6FML|rcsb pdb:6HKT|rcsb pdb:6HTS|rcsb pdb:6INQ|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6KXV|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:5FFW|rcsb pdb:5FWE|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MLC|rcsb pdb:6MUO|rcsb pdb:6MUP|rcsb pdb:6O1D|rcsb pdb:6R0C|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|refseq:NP_001029249.1|refseq:NP_003486.1|refseq:NP_003529.1|refseq:NP_003530.1|refseq:NP_003531.1|refseq:NP_003532.1|refseq:NP_003533.1|refseq:NP_003534.1|refseq:NP_003535.1|refseq:NP_003536.1|refseq:NP_003537.1|refseq:NP_003539.1|rcsb pdb:6R92|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6RNY|rcsb pdb:6RXS|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2K|rcsb pdb:6V92|rcsb pdb:6VO5|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6YOV|rcsb pdb:7A08|rcsb pdb:7BWD|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:7CCR|rcsb pdb:7CIZ|rcsb pdb:7CJ0|rcsb pdb:7D1Z|rcsb pdb:7D20|rcsb pdb:7DBP|rcsb pdb:7JO9|rcsb pdb:7JOA|rcsb pdb:7JZV|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7LMK|rcsb pdb:7LMM|rcsb pdb:7LYC|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|refseq:NP_068803.1|refseq:NP_778224.1|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3F4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727414|uniprotkb:Q9UQC8|uniprotkb:Q9NTK0|uniprotkb:Q5TZT4|intact:EBI-6190807|uniprotkb:B4DNJ6|uniprotkb:B2R5S5|ensembl:ENSP00000392270	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:strap_human(display_long)|uniprotkb:UNR-interacting protein(gene name synonym)|uniprotkb:WD-40 repeat protein PT-WD(gene name synonym)|uniprotkb:MAP activator with WD repeats(gene name synonym)|uniprotkb:STRAP(gene name)|psi-mi:STRAP(display_short)|uniprotkb:MAWD(gene name synonym)|uniprotkb:UNRIP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009109.3|ensembl:ENSG00000023734(gene)|ensembl:ENST00000419869(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:Q9Y3F4|reactome:R-HSA-2173788	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/IqZt6BHPxD3S/THUZry4+QUvCE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P47897	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347462|uniprotkb:B4DWJ2|ensembl:ENSP00000307567	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syq_human(display_long)|uniprotkb:QARS1(gene name)|psi-mi:QARS1(display_short)|uniprotkb:Glutaminyl-tRNA synthetase(gene name synonym)|uniprotkb:QARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005042.1|ensembl:ENSG00000172053(gene)|ensembl:ENST00000306125(transcript)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004514(Glutaminyl-tRNA synthetase, class Ic)|interpro:IPR007638(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 2)|interpro:IPR007639(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 1)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR042558|interpro:IPR042559|mint:P47897|rcsb pdb:4R3Z|rcsb pdb:4YE6|rcsb pdb:4YE8|rcsb pdb:4YE9|reactome:R-HSA-2408522|go:"GO:0006469"(negative regulation of protein kinase activity)|reactome:R-HSA-379716|reactome:R-HSA-379726|go:"GO:0007420"(brain development)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_001259002.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Q8LR+aWJJue/ixtD3ZYDpC/D3o9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22626	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299649|ensembl:ENSP00000346694|ensembl:ENSP00000349101|ensembl:ENSP00000354021|ensembl:ENSP00000503360|ensembl:ENSP00000503476|ensembl:ENSP00000503514|ensembl:ENSP00000503885|ensembl:ENSP00000504329|uniprotkb:P22627|uniprotkb:A8K064|uniprotkb:Q9UC98|uniprotkb:Q9UDJ2|uniprotkb:A0A024RA27|uniprotkb:A0A024RA61	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa2_human(display_long)|uniprotkb:HNRNPA2B1(gene name)|psi-mi:HNRNPA2B1(display_short)|uniprotkb:HNRPA2B1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|ensembl:ENST00000679001(transcript)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0050658"(RNA transport)|ensembl:ENST00000679021(transcript)|go:"GO:0070062"(extracellular exosome)|ensembl:ENST00000679123(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:1990428"(miRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034486|interpro:IPR034489|interpro:IPR035979|mint:P22626|rcsb pdb:1X4B|rcsb pdb:5EN1|rcsb pdb:5HO4|rcsb pdb:5WWE|rcsb pdb:5WWF|rcsb pdb:5WWG|rcsb pdb:6WPQ|rcsb pdb:6WQK|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|ensembl:ENSG00000122566(gene)|ensembl:ENST00000354667(transcript)|ensembl:ENST00000356674(transcript)|ensembl:ENST00000360787(transcript)|ensembl:ENST00000676746(transcript)|ensembl:ENST00000678675(transcript)|refseq:NP_002128.1|refseq:NP_112533.1|dip:DIP-32877N|refseq:XP_005249786.1|refseq:XP_016867598.1|refseq:XP_016867599.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N2NeJVio9eYQULNcdE1KXtd2KPw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63220	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714051|uniprotkb:P35265|ensembl:ENSP00000345957	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs21_human(display_long)|uniprotkb:RPS21(gene name)|psi-mi:RPS21(display_short)|uniprotkb:Small ribosomal subunit protein eS21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000171858(gene)|ensembl:ENST00000343986(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000461"("endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001015.1|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR001931(Ribosomal protein S21e)|interpro:IPR018279|interpro:IPR038579|mint:P63220|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6ZMO|rcsb pdb:6G5H|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6G5I|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:7K5I|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3gi91+fAL7ogzcoJlVEaN4D+87A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05388	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354101|uniprotkb:Q9BVK4|intact:EBI-8012155|intact:MINT-8395053|uniprotkb:Q3B7A4|ensembl:ENSP00000339027|ensembl:ENSP00000376299|ensembl:ENSP00000449328	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rla0_human(display_long)|uniprotkb:RPLP0(gene name)|psi-mi:RPLP0(display_short)|uniprotkb:60S ribosomal protein L10E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000993.1|refseq:NP_444505.1|ensembl:ENSG00000089157(gene)|ensembl:ENST00000228306(transcript)|ensembl:ENST00000392514(transcript)|ensembl:ENST00000551150(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0098794"(postsynapse)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR030670|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:P05388|rcsb pdb:4V6W|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8950505|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xv3QHqnXxvCd3BOIeHVkqEnSNNk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99615	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92688	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13185	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78176|ensembl:ENSP00000336687|ensembl:ENSP00000379670|uniprotkb:Q96CD7|uniprotkb:Q99409|uniprotkb:Q9BVS3|uniprotkb:Q9P0Z6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cbx3_human(display_long)|uniprotkb:CBX3(gene name)|psi-mi:CBX3(display_short)|uniprotkb:Heterochromatin protein 1 homolog gamma(gene name synonym)|uniprotkb:Modifier 2 protein(gene name synonym)|uniprotkb:HECH(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|ensembl:ENSG00000122565(gene)|ensembl:ENST00000337620(transcript)|ensembl:ENST00000396386(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR038033|mint:Q13185|rcsb pdb:2L11|rcsb pdb:3DM1|rcsb pdb:3KUP|rcsb pdb:3TZD|go:"GO:0005637"(nuclear inner membrane)|rcsb pdb:6HW2|reactome:R-HSA-427389|reactome:R-HSA-73772|reactome:R-HSA-8953750|rcsb pdb:5T1I|refseq:NP_009207.2|refseq:NP_057671.2|refseq:XP_005249668.1|dip:DIP-5985N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6L5OQHfxCBkmPV5Z0XihmXx4mFQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43390	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713419|uniprotkb:S4R3J4|uniprotkb:Q5TEH1|ensembl:ENSP00000304405|ensembl:ENSP00000363741|ensembl:ENSP00000489252|ensembl:ENSP00000489371|uniprotkb:Q9BV64|uniprotkb:Q2L7G6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpr_human(display_long)|uniprotkb:HNRPR(gene name synonym)|uniprotkb:HNRNPR(gene name)|psi-mi:HNRNPR(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001095868.1|refseq:XP_005245768.1|ensembl:ENSG00000125944(gene)|ensembl:ENSG00000282958(gene)|ensembl:ENST00000302271(transcript)|ensembl:ENST00000374612(transcript)|ensembl:ENST00000634263(transcript)|ensembl:ENST00000634766(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043679"(axon terminus)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034411|interpro:IPR035979|mint:O43390|rcsb pdb:2DK2|reactome:R-HSA-72163|reactome:R-HSA-72203|interpro:IPR041337|refseq:NP_005817.1|refseq:XP_011538773.1|refseq:NP_001284549.1|refseq:XP_016855497.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UiOaRbnMd1S2FthR4RWltyq6xT49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55060	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WWM7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-948363|ensembl:ENSP00000338718|uniprotkb:O95135|uniprotkb:Q6NVJ8|uniprotkb:Q6PJW6|uniprotkb:Q8IU61|uniprotkb:Q8IU95|uniprotkb:Q8WWM3|uniprotkb:Q8WWM4|uniprotkb:Q8WWM5|uniprotkb:Q8WWM6|uniprotkb:Q99703|uniprotkb:B9EGM2|uniprotkb:E9PAR9|uniprotkb:A8K1R6|uniprotkb:Q63ZY4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atx2l_human(display_long)|uniprotkb:Ataxin-2 domain protein(gene name synonym)|uniprotkb:Ataxin-2-related protein(gene name synonym)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)|uniprotkb:A2D(gene name synonym)|uniprotkb:A2LG(gene name synonym)|uniprotkb:A2LP(gene name synonym)|uniprotkb:A2RP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000168488(gene)|ensembl:ENST00000336783(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045296"(cadherin binding)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q8WWM7|refseq:NP_009176.2|refseq:NP_663760.1|refseq:NP_680780.1|refseq:NP_680781.1|refseq:XP_005255123.1|refseq:NP_059867.3|refseq:NP_680782.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:t7lrS10IM/5pt+rrbqBRowZ6b+09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y295	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719554|uniprotkb:Q6FGP8|uniprotkb:Q8WW69|uniprotkb:Q9UGF2|uniprotkb:B2RDS8|ensembl:ENSP00000329715	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:drg1_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 3(gene name synonym)|uniprotkb:DRG1(gene name)|psi-mi:DRG1(display_short)|uniprotkb:NEDD3(gene name synonym)|uniprotkb:Translation factor GTPase DRG1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004138.1|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|rcsb pdb:2EKI|go:"GO:0005844"(polysome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007275"(multicellular organism development)|ensembl:ENSG00000185721(gene)|ensembl:ENST00000331457(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gVbgvaeulEwp7MdnP+qRgZ/aawA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13639	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352560|uniprotkb:Q58J86|uniprotkb:B2RMP5|uniprotkb:D6W618|ensembl:ENSP00000307940	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef2_human(display_long)|uniprotkb:EEF2(gene name)|psi-mi:EEF2(display_short)|uniprotkb:EF2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001952.1|ensembl:ENSG00000167658(gene)|ensembl:ENST00000309311(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P13639|rcsb pdb:4V6X|rcsb pdb:6D9J|rcsb pdb:6Z6M|rcsb pdb:6Z6N|reactome:R-HSA-156902|reactome:R-HSA-5336415|reactome:R-HSA-5358493|reactome:R-HSA-6798695|reactome:R-HSA-8876725	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:US1dzGQ5V1oBXVtYeGt5H3HCIr09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08238	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wOsW7C10v2oMsM+REE38K6PAan09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75179	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355530|uniprotkb:Q6PJ85|uniprotkb:Q6PK85|uniprotkb:Q6PKA2|uniprotkb:Q86XI3|uniprotkb:Q8NDR5|uniprotkb:Q96I86|uniprotkb:Q9H6J9|uniprotkb:Q9H288|ensembl:ENSP00000351416|uniprotkb:G5E964|uniprotkb:E7EUV3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anr17_human(display_long)|uniprotkb:ANKRD17(gene name)|psi-mi:ANKRD17(display_short)|uniprotkb:GTAR(gene name synonym)|uniprotkb:KIAA0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-16(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_115593.3|refseq:NP_942592.1|refseq:NP_056389.1|ensembl:ENSG00000132466(gene)|ensembl:ENST00000358602(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:O75179|go:"GO:0031965"(nuclear membrane)|refseq:NP_001273700.1|ensembl:ENST00000330838|ensembl:ENSP00000332265|ensembl:ENSP00000351416|ensembl:ENST00000509867|ensembl:ENSP00000427151|dip:DIP-47290N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l/gkMCasWF6pn6feuIzeQKWwwKM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UPN3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-522925|uniprotkb:E9PJT0|uniprotkb:O75053|uniprotkb:Q5VW20|uniprotkb:Q8WXY2|uniprotkb:Q9H540|uniprotkb:Q9UKP0|uniprotkb:Q9ULG9|intact:EBI-28967632|uniprotkb:B1ALC5|uniprotkb:Q8WXY1|uniprotkb:Q96PK2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:macf1_human(display_long)|uniprotkb:Actin cross-linking family protein 7(gene name synonym)|uniprotkb:Macrophin-1(gene name synonym)|uniprotkb:Trabeculin-alpha(gene name synonym)|uniprotkb:620 kDa actin-binding protein(gene name synonym)|uniprotkb:MACF1(gene name)|psi-mi:MACF1(display_short)|uniprotkb:ABP620(gene name synonym)|uniprotkb:ACF7(gene name synonym)|uniprotkb:KIAA0465(gene name synonym)|uniprotkb:KIAA1251(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000361689|ensembl:ENSP00000354573|ensembl:ENSG00000127603|refseq:NP_036222.3|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0150011"(regulation of neuron projection arborization)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR011992(EF-Hand type)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|rcsb pdb:4Z6G|rcsb pdb:5VE9|rcsb pdb:5X57|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|dip:DIP-50616N|mint:Q9UPN3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G5PesqPZZxQhwDgW0pBJSkJNcZ49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16695	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52907	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355586|uniprotkb:Q53FQ6|uniprotkb:Q6FHD5|ensembl:ENSP00000263168	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:caza1_human(display_long)|uniprotkb:CAPZA1(gene name)|psi-mi:CAPZA1(display_short)|uniprotkb:CapZ alpha-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006126.1|ensembl:ENSG00000116489(gene)|ensembl:ENST00000263168(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P52907|rcsb pdb:1MQ1|rcsb pdb:1MWN|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-879415|reactome:R-HSA-8950505|reactome:R-HSA-9662360|reactome:R-HSA-983231	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:97S4WPtjgt4MDLoptRhQ2yH8UNE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07814	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15029	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6M1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1024419|intact:EBI-1059063|intact:EBI-1237206|uniprotkb:A0A4Z0|uniprotkb:B3FTN2|uniprotkb:B3FTN3|uniprotkb:B3FTN4|ensembl:ENSP00000371634	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2b2_human(display_long)|uniprotkb:IGF-II mRNA-binding protein 2(gene name synonym)|uniprotkb:Hepatocellular carcinoma autoantigen p62(gene name synonym)|uniprotkb:VICKZ family member 2(gene name synonym)|uniprotkb:IGF2BP2(gene name)|psi-mi:IGF2BP2(display_short)|uniprotkb:IMP2(gene name synonym)|uniprotkb:VICKZ2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001278801.1|refseq:NP_001278802.1|refseq:NP_001278803.1|refseq:NP_001278804.1|refseq:NP_001007226.1|refseq:NP_006539.3|ensembl:ENSG00000073792(gene)|ensembl:ENST00000382199(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR028743|interpro:IPR034843|interpro:IPR035979|interpro:IPR036612|mint:Q9Y6M1|rcsb pdb:2CQH|rcsb pdb:6ROL|reactome:R-HSA-428359|dip:DIP-35539N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k45UViReMAxCv2cu7+tx+auevQc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07910	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357966|uniprotkb:P22628|uniprotkb:Q53EX2|uniprotkb:Q59FD3|uniprotkb:Q5FWE8|uniprotkb:Q86SF8|uniprotkb:Q86U45|uniprotkb:Q96HK7|uniprotkb:Q96HM4|uniprotkb:Q96IY5|uniprotkb:Q9BTS3|uniprotkb:D3DS19|uniprotkb:D3DS22|intact:EBI-28976506|ensembl:ENSP00000404848|ensembl:ENSP00000451291|ensembl:ENSP00000452276	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpc_human(display_long)|uniprotkb:HNRNPC(gene name)|psi-mi:HNRNPC(display_short)|uniprotkb:HNRPC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070910.1|refseq:NP_001070911.1|refseq:NP_004491.2|refseq:NP_112604.2|ensembl:ENSP00000404848|ensembl:ENST00000430246|ensembl:ENSP00000442816|ensembl:ENST00000553300|ensembl:ENSP00000450544|ensembl:ENSP00000451291|ensembl:ENST00000554969|ensembl:ENSP00000452276|ensembl:ENSP00000450725|ensembl:ENST00000555883|ensembl:ENSP00000450629|ensembl:ENST00000556628|ensembl:ENSP00000451652|ensembl:ENST00000556897|ensembl:ENSP00000451176|refseq:XP_011535010.1|refseq:XP_011535011.1|refseq:XP_011535012.1|refseq:XP_011535013.1|refseq:XP_011535014.1|refseq:XP_016876741.1|refseq:XP_016876742.1|dip:DIP-29854N|refseq:XP_006720188.1|ensembl:ENSG00000092199(gene)|ensembl:ENST00000420743(transcript)|ensembl:ENST00000554455(transcript)|ensembl:ENST00000557201(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR035979|mint:P07910|rcsb pdb:1TXP|rcsb pdb:1WF2|rcsb pdb:2MXY|rcsb pdb:2MZ1|rcsb pdb:3LN4|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Fj5tiH0wrNUjTnsURIg8dB8laMg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62266	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353072|ensembl:ENSP00000296674|ensembl:ENSP00000498621|uniprotkb:P39028|uniprotkb:Q6IB08	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs23_human(display_long)|uniprotkb:RPS23(gene name)|psi-mi:RPS23(display_short)|uniprotkb:Small ribosomal subunit protein uS12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000186468(gene)|ensembl:ENST00000296674(transcript)|ensembl:ENST00000651545(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:1990145"(maintenance of translational fidelity)|interpro:IPR005680(Ribosomal protein S23, eukaryotic/archaeal)|interpro:IPR006032(Ribosomal protein S12/S23)|rcsb pdb:5T2C|rcsb pdb:5VYC|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|mint:P62266|rcsb pdb:6G4W|rcsb pdb:4CXG|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:4CXH|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:4UG0|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|refseq:NP_001016.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MWZPvSL/G45ocaxA5AXKCkDQxNU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BXJ9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042540|uniprotkb:Q52LG9|uniprotkb:Q8IWH4|uniprotkb:Q8NEV2|uniprotkb:Q9H8P6|uniprotkb:D3DNY6|ensembl:ENSP00000296543	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:naa15_human(display_long)|uniprotkb:NAA15(gene name)|psi-mi:NAA15(display_short)|uniprotkb:GA19(gene name synonym)|uniprotkb:NATH(gene name synonym)|uniprotkb:TBDN100(gene name synonym)|uniprotkb:Gastric cancer antigen Ga19(gene name synonym)|uniprotkb:N-terminal acetyltransferase(gene name synonym)|uniprotkb:Protein tubedown-1(gene name synonym)|uniprotkb:Tbdn100(gene name synonym)|uniprotkb:NARG1(gene name synonym)|uniprotkb:NMDA receptor-regulated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_476516.1|go:"GO:0016604"(nuclear body)|go:"GO:0017196"(N-terminal peptidyl-methionine acetylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031415"(NatA complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR021183|mint:Q9BXJ9|rcsb pdb:6C95|rcsb pdb:6C9M|rcsb pdb:6PPL|rcsb pdb:6PW9|ensembl:ENSG00000164134(gene)|ensembl:ENST00000296543(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006474"(N-terminal protein amino acid acetylation)|go:"GO:0016020"(membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BGW5jQRBYXuf75thzj6cWvL2A5Y9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75367	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2868511|uniprotkb:Q7Z5E3|uniprotkb:Q9UP96|uniprotkb:Q9H8P3|uniprotkb:Q503A8|uniprotkb:O75377|uniprotkb:Q96D41|ensembl:ENSP00000423563|ensembl:ENSP00000424971	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h2ay_human(display_long)|uniprotkb:MACROH2A1(gene name)|psi-mi:MACROH2A1(display_short)|uniprotkb:H2AFY(gene name synonym)|uniprotkb:Histone H2A.y(gene name synonym)|uniprotkb:Medulloblastoma antigen MU-MB-50.205(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011542031.1|refseq:XP_011542032.1|refseq:NP_001035248.1|refseq:NP_004884.1|refseq:NP_613075.1|refseq:NP_613258.2|dip:DIP-44283N|ensembl:ENSG00000113648(gene)|ensembl:ENST00000510038(transcript)|ensembl:ENST00000511689(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000182"(rDNA binding)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0007549"(dosage compensation)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902750"(negative regulation of cell cycle G2/M phase transition)|go:"GO:1902882"(regulation of response to oxidative stress)|go:"GO:1902883"(negative regulation of response to oxidative stress)|go:"GO:1902884"(positive regulation of response to oxidative stress)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|go:"GO:1904815"(negative regulation of protein localization to chromosome, telomeric region)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|interpro:IPR032454|interpro:IPR035796|interpro:IPR043472|mint:O75367|rcsb pdb:1U35|rcsb pdb:1ZR3|rcsb pdb:1ZR5|rcsb pdb:2F8N|rcsb pdb:2FXK|rcsb pdb:3HQH|rcsb pdb:3HSV|rcsb pdb:3IID|rcsb pdb:3IIF|rcsb pdb:3IVB|rcsb pdb:5IIT|rcsb pdb:5LNC|interpro:IPR002119(Histone H2A)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0FCoM0/4mTtnc7cPDUleKuZ3HgM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-744603|uniprotkb:Q14818|uniprotkb:Q14819|uniprotkb:Q15913|uniprotkb:Q8IY00|uniprotkb:Q92744|uniprotkb:Q92745|uniprotkb:Q969H7|uniprotkb:Q9BW01|uniprotkb:Q9UEI0|uniprotkb:B7Z1Q1|uniprotkb:C9JJE2|ensembl:ENSP00000366607	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf01_human(display_long)|uniprotkb:Zinc finger protein 162(gene name synonym)|uniprotkb:Transcription factor ZFM1(gene name synonym)|uniprotkb:Zinc finger gene in MEN1 locus(gene name synonym)|uniprotkb:Mammalian branch point-binding protein(gene name synonym)|uniprotkb:SF1(gene name)|psi-mi:SF1(display_short)|uniprotkb:ZFM1(gene name synonym)|uniprotkb:ZNF162(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001171501.1|refseq:NP_001171502.1|refseq:NP_004621.2|refseq:NP_973724.1|refseq:NP_973727.1|rcsb pdb:4FXX|rcsb pdb:4FXW|reactome:R-HSA-72163|refseq:XP_016873733.1|ensembl:ENSG00000168066(gene)|ensembl:ENST00000377390(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005840"(ribosome)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030238"(male sex determination)|go:"GO:0030575"(nuclear body organization)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045131"(pre-mRNA branch point binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR031150|interpro:IPR032570|interpro:IPR036612|mint:Q15637|rcsb pdb:1K1G|rcsb pdb:1O0P|rcsb pdb:1OPI|rcsb pdb:2M09|rcsb pdb:2M0G|refseq:NP_001333292.1|refseq:NP_001333293.1|dip:DIP-29410N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N4k5Rvc5EDsSJt50J4ojje9p0249606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36404	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-752365|uniprotkb:Q9BUK8|uniprotkb:G3V184|ensembl:ENSP00000246747|ensembl:ENSP00000436021	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arl2_human(display_long)|uniprotkb:ARL2(gene name)|psi-mi:ARL2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186674.1|refseq:NP_001658.2|dip:DIP-47535N|ensembl:ENSG00000213465(gene)|ensembl:ENST00000246747(transcript)|ensembl:ENST00000529384(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:P36404|rcsb pdb:3DOE|rcsb pdb:3DOF|reactome:R-HSA-389977|reactome:R-HSA-83936|reactome:R-HSA-9648002	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ArQxx65a8vITU2O0Kr0Qo0hqiqU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BWF3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2856454|uniprotkb:B3KUN0|uniprotkb:Q8WU85|uniprotkb:Q6P1P2|uniprotkb:O02916|uniprotkb:Q4VC48|uniprotkb:B4E1U0|uniprotkb:E7EQS3|ensembl:ENSP00000309166|ensembl:ENSP00000386561|ensembl:ENSP00000386894	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm4_human(display_long)|uniprotkb:RBM4(gene name)|psi-mi:RBM4(display_short)|uniprotkb:RBM4A(gene name synonym)|uniprotkb:Lark homolog(gene name synonym)|uniprotkb:RNA-binding motif protein 4(gene name synonym)|uniprotkb:RNA-binding motif protein 4a(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001185772.1|refseq:NP_002887.2|refseq:NP_001185773.1|dip:DIP-44199N|ensembl:ENSG00000173933(gene)|ensembl:ENST00000310092(transcript)|ensembl:ENST00000408993(transcript)|ensembl:ENST00000409406(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002190"(cap-independent translational initiation)|go:"GO:0002192"(IRES-dependent translational initiation of linear mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0097158"(pre-mRNA intronic pyrimidine-rich binding)|go:"GO:0097167"(circadian regulation of translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR034897|interpro:IPR034898|interpro:IPR035979|mint:Q9BWF3|rcsb pdb:2DNQ|reactome:R-HSA-400253|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hbW6dv/AEWQz3mWvA2/9n8h/bbA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16658	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351076|uniprotkb:Q96IH1|uniprotkb:A6NI89|uniprotkb:Q96IC5|uniprotkb:Q9BRF1|uniprotkb:B2RE97|ensembl:ENSP00000371798	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fscn1_human(display_long)|uniprotkb:FSCN1(gene name)|psi-mi:FSCN1(display_short)|uniprotkb:FAN1(gene name synonym)|uniprotkb:HSN(gene name synonym)|uniprotkb:SNL(gene name synonym)|uniprotkb:Singed-like protein(gene name synonym)|uniprotkb:55 kDa actin-bundling protein(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0044393"(microspike)|go:"GO:0045296"(cadherin binding)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR008999(Actin_cross-linking)|interpro:IPR010431(Fascin)|interpro:IPR022768|interpro:IPR024703|interpro:IPR030146|mint:Q16658|rcsb pdb:1DFC|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030035"(microspike assembly)|rcsb pdb:3LLP|refseq:NP_003079.1|ensembl:ENSG00000075618(gene)|ensembl:ENST00000382361(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008144"(obsolete drug binding)|rcsb pdb:3P53|rcsb pdb:4GOV|rcsb pdb:4GOY|rcsb pdb:4GP3|rcsb pdb:6B0T|rcsb pdb:6I0Z|rcsb pdb:6I10|rcsb pdb:6I11|rcsb pdb:6I12|rcsb pdb:6I13|rcsb pdb:6I14|rcsb pdb:6I15|rcsb pdb:6I16|rcsb pdb:6I17|rcsb pdb:6I18|reactome:R-HSA-6785807|rcsb pdb:4GP0|dip:DIP-33171N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yc9EJDCKGJGGEcEueR/yAY/fxRg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36578	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348313|ensembl:ENSP00000311430|uniprotkb:P39029|uniprotkb:Q4VBR0|uniprotkb:Q969Z9|uniprotkb:A8K502	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl4_human(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:RPL1(gene name synonym)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000174444(gene)|ensembl:ENST00000307961(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR025755|mint:P36578|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|interpro:IPR023574|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OM0|refseq:NP_000959.2|dip:DIP-27559N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:34il/jyrW0Dqj0eA8GBFgUk05XU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36542	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10412	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358163|uniprotkb:Q4VB25|ensembl:ENSP00000307705	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h14_human(display_long)|uniprotkb:H1-4(gene name)|psi-mi:H1-4(display_short)|uniprotkb:H1F4(gene name synonym)|uniprotkb:HIST1H1E(gene name synonym)|uniprotkb:Histone H1b(gene name synonym)|uniprotkb:Histone H1s-4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005312.1|rcsb pdb:6H8P|rcsb pdb:7K5Y|rcsb pdb:7K63|go:"GO:0032564"(dATP binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P10412|rcsb pdb:3TZD|rcsb pdb:5JJZ|reactome:R-HSA-140342|reactome:R-HSA-2559584|ensembl:ENSG00000168298(gene)|ensembl:ENST00000304218(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000792"(heterochromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016208"(AMP binding)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yT8wBbspLLR8G3DrgpFeWEOPgac9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31942	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711437|uniprotkb:Q9NPI4|uniprotkb:Q9UFU4|uniprotkb:Q9Y4J5|uniprotkb:Q9BSX1|uniprotkb:Q9NP53|uniprotkb:Q9NP96|uniprotkb:Q9NPA7|ensembl:ENSP00000265866|uniprotkb:A8K682|uniprotkb:B3KRE1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrh3_human(display_long)|uniprotkb:HNRNPH3(gene name)|psi-mi:HNRNPH3(display_short)|uniprotkb:HNRPH3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein 2H9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000096746(gene)|ensembl:ENST00000265866(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034969|interpro:IPR034970|interpro:IPR035979|mint:P31942|refseq:NP_036339.1|refseq:NP_067676.2|refseq:NP_001309363.1|refseq:NP_001309365.1|refseq:NP_001309366.1|refseq:NP_001309367.1|refseq:NP_001309368.1|refseq:NP_001309369.1|refseq:NP_001309370.1|refseq:NP_001309374.1|refseq:NP_001309375.1|refseq:NP_001309376.1|refseq:NP_001309377.1|refseq:NP_001309378.1|refseq:XP_016871657.1|refseq:XP_016871658.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iJGBIhPXnQIIFQmgxWB1WjwVXSY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14157	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15371	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15717	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374260|uniprotkb:Q9BTT1|ensembl:ENSP00000385269|ensembl:ENSP00000472197|intact:EBI-6190219|uniprotkb:B4DVB8|uniprotkb:Q53XN6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:elav1_human(display_long)|uniprotkb:ELAVL1(gene name)|psi-mi:ELAVL1(display_short)|uniprotkb:HUR(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|ensembl:ENSG00000066044(gene)|ensembl:ENST00000407627(transcript)|ensembl:ENST00000596459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|refseq:NP_001410.2|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:Q15717|rcsb pdb:3HI9|rcsb pdb:4ED5|rcsb pdb:4EGL|rcsb pdb:4FXV|rcsb pdb:5SZW|rcsb pdb:6G2K|rcsb pdb:6GC5|rcsb pdb:6GD1|rcsb pdb:6GD2|rcsb pdb:6GD3|reactome:R-HSA-450520|reactome:R-HSA-72163|dip:DIP-31291N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PciL5KuvP+2aUUv9cv7gWScgbw89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NU22	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050480|uniprotkb:O15019|uniprotkb:Q5T794|ensembl:ENSP00000358400|ensembl:ENSP00000486270|ensembl:ENSP00000499843|ensembl:ENSP00000499895	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mdn1_human(display_long)|uniprotkb:MIDAS-containing protein(gene name synonym)|uniprotkb:Dynein-related AAA-ATPase MDN1(gene name synonym)|uniprotkb:MDN1(gene name)|psi-mi:MDN1(display_short)|uniprotkb:KIAA0301(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055426.1|ensembl:ENSG00000112159(gene)|ensembl:ENSG00000288121(gene)|ensembl:ENST00000369393(transcript)|ensembl:ENST00000629399(transcript)|ensembl:ENST00000672983(transcript)|ensembl:ENST00000673332(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR012099(Midasin)|interpro:IPR027417|interpro:IPR036465|interpro:IPR040848|interpro:IPR041190|mint:Q9NU22|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/LVYhffZVpP0pYVM6hLNltoc6pY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07384	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1542113|uniprotkb:Q2TTR0|uniprotkb:Q6DHV4|ensembl:ENSP00000279247|ensembl:ENSP00000431686|ensembl:ENSP00000431984|ensembl:ENSP00000434176|ensembl:ENSP00000435272	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:can1_human(display_long)|uniprotkb:CAPN1(gene name)|psi-mi:CAPN1(display_short)|uniprotkb:CANPL1(gene name synonym)|uniprotkb:Calpain-1 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 1(gene name synonym)|uniprotkb:Calpain mu-type(gene name synonym)|uniprotkb:Micromolar-calpain(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 30 protein(gene name synonym)|uniprotkb:PIG30(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_006718761.1|refseq:NP_001185797.1|refseq:NP_001185798.1|refseq:NP_005177.2|refseq:XP_011543594.1|ensembl:ENSG00000014216(gene)|ensembl:ENST00000279247(transcript)|ensembl:ENST00000524773(transcript)|ensembl:ENST00000527323(transcript)|ensembl:ENST00000533129(transcript)|ensembl:ENST00000533820(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0060056"(mammary gland involution)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097264"(self proteolysis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029643|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P07384|rcsb pdb:1ZCM|rcsb pdb:2ARY|reactome:R-HSA-1474228|reactome:R-HSA-6798695|reactome:R-HSA-6809371|reactome:R-HSA-8862803	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hLf5vu04E7/yonXBb9VIZThbcxk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52292	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-349938|uniprotkb:Q9BRU5|ensembl:ENSP00000504685|intact:EBI-28977049|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|uniprotkb:B9EJD6|uniprotkb:Q53YE3|intact:EBI-9377406|uniprotkb:Q6NVW7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ima1_human(display_long)|uniprotkb:KPNA2(gene name)|psi-mi:KPNA2(display_short)|uniprotkb:RCH1(gene name synonym)|uniprotkb:SRP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002257.1|refseq:NP_001307540.1|ensembl:ENST00000330459(transcript)|ensembl:ENST00000537025(transcript)|ensembl:ENST00000579754(transcript)|ensembl:ENST00000584026(transcript)|ensembl:ENST00000677086(transcript)|ensembl:ENST00000679078(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52292|rcsb pdb:1EFX|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:3FEX|ensembl:ENSG00000182481(gene)|rcsb pdb:3FEY|rcsb pdb:3WPT|rcsb pdb:4E4V|rcsb pdb:4WV6|rcsb pdb:5H43|rcsb pdb:7N8J|reactome:R-HSA-111932|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-442729|reactome:R-HSA-5693548|reactome:R-HSA-9018519|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|ensembl:ENSP00000504685|dip:DIP-6205N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DFtAbvPxkzWJO/fRLPGxA6pEEJQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33993	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05787	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297852|uniprotkb:Q14099|uniprotkb:Q14716|uniprotkb:Q14717|uniprotkb:Q53GJ0|uniprotkb:Q6DHW5|uniprotkb:Q6GMY0|uniprotkb:Q6P4C7|uniprotkb:Q96J60|ensembl:ENSP00000293308|ensembl:ENSP00000447402|ensembl:ENSP00000447566|uniprotkb:A8K4H3|uniprotkb:B0AZN5|uniprotkb:F8VXB4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c8_human(display_long)|uniprotkb:Keratin-8(gene name synonym)|uniprotkb:KRT8(gene name)|psi-mi:KRT8(display_short)|uniprotkb:CYK8(gene name synonym)|uniprotkb:Cytokeratin-8(gene name synonym)|uniprotkb:Type-II keratin Kb8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243222.1|ensembl:ENSG00000170421(gene)|ensembl:ENST00000293308(transcript)|ensembl:ENST00000546897(transcript)|ensembl:ENST00000552551(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030018"(Z disc)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051707"(response to other organism)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P05787|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_002264.1|dip:DIP-424N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zyV8eOjx426ehjJYK4jsizORUws9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BQG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-676973|intact:EBI-2559619|uniprotkb:Q86VM3|uniprotkb:Q9BW49|uniprotkb:Q9P0V5|uniprotkb:Q9UF99|ensembl:ENSP00000254718	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mbb1a_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)|uniprotkb:P160(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001099008.1|refseq:NP_055335.2|ensembl:ENST00000254718(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|ensembl:ENSG00000132382(gene)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q9BQG0|reactome:R-HSA-5250924	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ScabTPXvbX/5VRsnaRQXUIlANow9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23396	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351193|uniprotkb:Q498B5|uniprotkb:Q8NI95|uniprotkb:B2R7N5|ensembl:ENSP00000433821|ensembl:ENSP00000434643|ensembl:ENSP00000436971|uniprotkb:J3KN86	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs3_human(display_long)|uniprotkb:RPS3(gene name)|psi-mi:RPS3(display_short)|uniprotkb:Small ribosomal subunit protein uS3(gene name synonym)|uniprotkb:OK/SW-cl.26(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000996.2|ensembl:ENSG00000149273(gene)|ensembl:ENST00000524851(transcript)|ensembl:ENST00000527446(transcript)|ensembl:ENST00000531188(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032358"(oxidized pyrimidine DNA binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045738"(negative regulation of DNA repair)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061481"(response to TNF agonist)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902546"(positive regulation of DNA N-glycosylase activity)|go:"GO:1905053"(positive regulation of base-excision repair)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR004044(K Homology, type 2)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|go:"GO:0071159"(NF-kappaB complex)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR018280|interpro:IPR036419|mint:P23396|rcsb pdb:1WH9|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|go:"GO:0072686"(mitotic spindle)|go:"GO:0097100"(supercoiled DNA binding)|rcsb pdb:6QZP|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|refseq:NP_001243731.1|refseq:NP_001247436.1|refseq:NP_001247435.1|dip:DIP-33177N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fsDW18AMR3YyEEIhMVcngYRWkps9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P84085	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4289908|uniprotkb:P26437|ensembl:ENSP00000000233	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arf5_human(display_long)|uniprotkb:ARF5(gene name)|psi-mi:ARF5(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000004059(gene)|ensembl:ENST00000000233(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84085|rcsb pdb:2B6H|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001653.1|dip:DIP-61289N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02545	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96PK6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-954272|ensembl:ENSP00000311747|uniprotkb:O75932|uniprotkb:Q53GV1|uniprotkb:Q68DQ9|uniprotkb:Q96PK5|uniprotkb:B3KMN4|uniprotkb:Q2PYN1|uniprotkb:D6RGD8|uniprotkb:B0LM41|intact:EBI-16430855|intact:EBI-16472484	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbm14_human(display_long)|uniprotkb:RNA-binding motif protein 14(gene name synonym)|uniprotkb:RRM-containing coactivator activator/modulator(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein(gene name synonym)|uniprotkb:RBM14(gene name)|psi-mi:RBM14(display_short)|uniprotkb:SIP(gene name synonym)|uniprotkb:Paraspeckle protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000239306(gene)|ensembl:ENST00000310137(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009725"(response to hormone)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034506|interpro:IPR034507|go:"GO:0098534"(centriole assembly)|interpro:IPR035979|mint:Q96PK6|rcsb pdb:2DNP|reactome:R-HSA-8941326|refseq:NP_001185765.1|refseq:NP_006319.1|ensembl:ENSP00000311747|ensembl:ENST00000393979|ensembl:ENSP00000377548|ensembl:ENST00000409738|ensembl:ENSP00000386995|refseq:NP_001185766.1|refseq:NP_001185774.1|dip:DIP-50126N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Q0UBl2qmfwQTPwUQ7ZDwGIMOYoA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q86UX7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373158|uniprotkb:Q8IUA1|uniprotkb:Q8N207|uniprotkb:Q9BT48|ensembl:ENSP00000279227	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:urp2_human(display_long)|uniprotkb:FERMT3(gene name)|psi-mi:FERMT3(display_short)|uniprotkb:KIND3(gene name synonym)|uniprotkb:MIG2B(gene name synonym)|uniprotkb:URP2(gene name synonym)|uniprotkb:Unc-112-related protein 2(gene name synonym)|uniprotkb:Kindlin-3(gene name synonym)|uniprotkb:MIG2-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_113659.3|refseq:NP_848537.1|refseq:XP_011543596.1|ensembl:ENSG00000149781(gene)|ensembl:ENST00000279227(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042995"(cell projection)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR037837|interpro:IPR037843|interpro:IPR040790|rcsb pdb:2YS3|rcsb pdb:6V97|rcsb pdb:6V9G|rcsb pdb:7C3M|reactome:R-HSA-114608|refseq:XP_016873887.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BDLaeBD6Ycz4HAh/4QlZeSZurxY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62263	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352783|ensembl:ENSP00000311028|ensembl:ENSP00000385425|uniprotkb:P06366|uniprotkb:Q5BJI0|uniprotkb:B2R5G5|uniprotkb:D3DQG5|ensembl:ENSP00000385958|ensembl:ENSP00000428509	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs14_human(display_long)|uniprotkb:RPS14(gene name)|psi-mi:RPS14(display_short)|uniprotkb:Small ribosomal subunit protein uS11(gene name synonym)|uniprotkb:PRO2640(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164587(gene)|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001020242.1|refseq:NP_005608.1|refseq:NP_001020241.1|ensembl:ENST00000312037(transcript)|ensembl:ENST00000401695(transcript)|ensembl:ENST00000407193(transcript)|ensembl:ENST00000521466(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P62263|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ee3bJ5JYFaZXyCCRG9Wooopyz2o9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49327	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356658|uniprotkb:Q4LE83|uniprotkb:Q13479|uniprotkb:Q16702|uniprotkb:Q6P4U5|uniprotkb:Q6SS02|uniprotkb:Q969R1|uniprotkb:Q96C68|uniprotkb:Q96IT0|ensembl:ENSP00000304592	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fas_human(display_long)|uniprotkb:FASN(gene name)|psi-mi:FASN(display_short)|uniprotkb:FAS(gene name synonym)|uniprotkb:Type I fatty acid synthase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004095.4|ensembl:ENSG00000169710(gene)|ensembl:ENST00000306749(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003723"(RNA binding)|go:"GO:0004313"([acyl-carrier-protein] S-acetyltransferase activity)|go:"GO:0004314"([acyl-carrier-protein] S-malonyltransferase activity)|go:"GO:0004315"(3-oxoacyl-[acyl-carrier-protein] synthase activity)|go:"GO:0004316"("3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity")|go:"GO:0004317"(3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0004320"(oleoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0008659"("(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity")|go:"GO:0008693"(3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0016020"(membrane)|go:"GO:0016295"(myristoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0016296"(palmitoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031177"(phosphopantetheine binding)|go:"GO:0042470"(melanosome)|go:"GO:0042587"(glycogen granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0047451"(3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0102131"(obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity)|go:"GO:0102132"(obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity)|interpro:IPR001031(Thioesterase)|interpro:IPR001227(Acyl transferase region)|interpro:IPR006162(Phosphopantetheine attachment site)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011032(GroES-like)|interpro:IPR013149(Alcohol dehydrogenase, zinc-binding)|interpro:IPR013217(Methyltransferase type 12)|interpro:IPR013968(Polyketide synthase, KR)|interpro:IPR014030(Beta-ketoacyl synthase, N-terminal)|interpro:IPR014031(Beta-ketoacyl synthase, C-terminal)|interpro:IPR014043(Acyl transferase)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR016036(Malonyl-CoA ACP transacylase, ACP-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR018201|interpro:IPR020806|interpro:IPR020807|interpro:IPR020841|interpro:IPR020843|interpro:IPR029058|interpro:IPR029063|interpro:IPR032821|interpro:IPR036291|interpro:IPR036736|interpro:IPR042104|mint:P49327|rcsb pdb:1XKT|rcsb pdb:2CG5|rcsb pdb:2JFD|rcsb pdb:2JFK|rcsb pdb:2PX6|rcsb pdb:3HHD|rcsb pdb:3TJM|rcsb pdb:4PIV|rcsb pdb:4W82|rcsb pdb:4W9N|rcsb pdb:4Z49|rcsb pdb:5C37|rcsb pdb:6NNA|reactome:R-HSA-163765|reactome:R-HSA-199220|reactome:R-HSA-2426168|reactome:R-HSA-75105|reactome:R-HSA-9029558|go:"GO:0047117"("enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity")|refseq:XP_011521840.1|dip:DIP-33681N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bQYEH/uQ6l+SPzLBDNCV5yP+yzs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92499	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358474|ensembl:ENSP00000233084|ensembl:ENSP00000370745|ensembl:ENSP00000413767|ensembl:ENSP00000504080|uniprotkb:B4DME8|uniprotkb:B4DPN6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx1_human(display_long)|uniprotkb:DDX1(gene name)|psi-mi:DDX1(display_short)|uniprotkb:DEAD box protein 1(gene name synonym)|uniprotkb:DEAD box protein retinoblastoma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000079785(gene)|ensembl:ENST00000233084(transcript)|ensembl:ENST00000381341(transcript)|ensembl:ENST00000434671(transcript)|ensembl:ENST00000677302(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|refseq:NP_004930.1|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136|mint:Q92499|rcsb pdb:4XW3|reactome:R-HSA-6784531|dip:DIP-38163N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n2Zv07BpuUDT32/ttDzIFXH3yIQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22102	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356297|ensembl:ENSP00000371236|ensembl:ENSP00000371253|ensembl:ENSP00000371261|ensembl:ENSP00000459391|ensembl:ENSP00000459532|ensembl:ENSP00000461700|uniprotkb:D3DSF3|uniprotkb:D3DSF4|uniprotkb:O14659|uniprotkb:A8KA32|uniprotkb:A8K945|uniprotkb:Q52M77	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pur2_human(display_long)|uniprotkb:GART(gene name)|psi-mi:GART(display_short)|uniprotkb:PRGS(gene name synonym)|uniprotkb:PGFT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0046084"(adenine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000115(Phosphoribosylglycinamide synthetase)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR004607(Phosphoribosylglycinamide formyltransferase)|interpro:IPR004733(Phosphoribosylformylglycinamidine cyclo-ligase)|interpro:IPR010918(AIR synthase related protein, C-terminal)|ensembl:ENST00000571089(transcript)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|ensembl:ENST00000573055(transcript)|ensembl:ENST00000575273(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0004637"(phosphoribosylamine-glycine ligase activity)|go:"GO:0004641"(phosphoribosylformylglycinamidine cyclo-ligase activity)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|go:"GO:0004644"(phosphoribosylglycinamide formyltransferase activity)|interpro:IPR016185(PreATP-grasp-like fold)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR016188(PurM, N-terminal-like)|ensembl:ENSG00000159131(gene)|ensembl:ENSG00000262473(gene)|ensembl:ENST00000381815(transcript)|ensembl:ENST00000381831(transcript)|ensembl:ENST00000381839(transcript)|interpro:IPR020560|interpro:IPR020561|interpro:IPR020562|interpro:IPR036477|interpro:IPR036676|interpro:IPR036921|interpro:IPR037123|mint:P22102|rcsb pdb:1MEJ|rcsb pdb:1MEN|rcsb pdb:1MEO|rcsb pdb:1NJS|rcsb pdb:1RBM|rcsb pdb:1RBQ|rcsb pdb:1RBY|rcsb pdb:1RBZ|rcsb pdb:1RC0|rcsb pdb:1RC1|rcsb pdb:1ZLX|rcsb pdb:1ZLY|rcsb pdb:2QK4|rcsb pdb:2V9Y|rcsb pdb:4EW1|rcsb pdb:4EW2|rcsb pdb:4EW3|rcsb pdb:4ZYT|interpro:IPR020559|rcsb pdb:4ZYU|rcsb pdb:4ZYV|rcsb pdb:4ZYW|rcsb pdb:4ZYX|rcsb pdb:4ZYY|rcsb pdb:4ZYZ|rcsb pdb:4ZZ0|rcsb pdb:4ZZ1|rcsb pdb:4ZZ2|rcsb pdb:5J9F|rcsb pdb:7JG0|rcsb pdb:4ZZ3|refseq:NP_000810.1|refseq:NP_001129477.1|refseq:NP_001129478.1|refseq:NP_780294.1|rcsb pdb:7JG4|reactome:R-HSA-73817|rcsb pdb:7JG3|refseq:XP_011527828.1|refseq:XP_006724052.1|refseq:XP_006724053.1|refseq:XP_005260998.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7Iy33CtBsB8LHZFDP5mZ3eRX8pU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63173	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359141|uniprotkb:P23411|uniprotkb:B2R5A8|ensembl:ENSP00000309830|ensembl:ENSP00000390279|ensembl:ENSP00000434243	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl38_human(display_long)|uniprotkb:RPL38(gene name)|psi-mi:RPL38(display_short)|uniprotkb:Large ribosomal subunit protein eL38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000990.1|refseq:NP_001030335.1|ensembl:ENSG00000172809(gene)|ensembl:ENST00000311111(transcript)|ensembl:ENST00000439590(transcript)|ensembl:ENST00000533498(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0033291"(eukaryotic 80S initiation complex)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0048318"(axial mesoderm development)|interpro:IPR002675(Ribosomal protein L38e)|interpro:IPR038464|mint:P63173|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:5AJ0|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6kUSGJll3ldTTRzgVTSwBjgV19Y9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237119|uniprotkb:Q52LW9|uniprotkb:B2R5A3|ensembl:ENSP00000366618	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h2b1l_human(display_long)|uniprotkb:H2BC13(gene name)|psi-mi:H2BC13(display_short)|uniprotkb:H2BFC(gene name synonym)|uniprotkb:HIST1H2BL(gene name synonym)|uniprotkb:Histone H2B.c(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003510.1|dip:DIP-38154N|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|ensembl:ENSG00000185130(gene)|ensembl:ENST00000377401(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|interpro:IPR009072(Histone-fold)|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5250924|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vVD3xoHavMKCopzEez7zarZBKFc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14103	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299674|ensembl:ENSP00000313199|uniprotkb:P07029|uniprotkb:Q01858|uniprotkb:Q14100|uniprotkb:Q14101|uniprotkb:Q14102|uniprotkb:Q4W5A1|uniprotkb:A8K9J2|uniprotkb:Q9UCE8|uniprotkb:Q9UCE9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpd_human(display_long)|uniprotkb:HNRNPD(gene name)|psi-mi:HNRNPD(display_short)|uniprotkb:AUF1(gene name synonym)|uniprotkb:HNRPD(gene name synonym)|uniprotkb:AU-rich element RNA-binding protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000138668(gene)|ensembl:ENST00000313899(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1901355"(response to rapamycin)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1904586"(cellular response to putrescine)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990828"(hepatocyte dedifferentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR035979|mint:Q14103|rcsb pdb:1HD0|rcsb pdb:1HD1|rcsb pdb:1IQT|rcsb pdb:1WTB|rcsb pdb:1X0F|rcsb pdb:2Z5N|rcsb pdb:5IM0|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|reactome:R-HSA-450408|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:NP_001003810.1|refseq:NP_002129.2|refseq:NP_112737.1|refseq:NP_112738.1|dip:DIP-31163N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LrC0nOpN6jGn3WELs5NEOccNPnw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24534	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354334|uniprotkb:Q6IBH9|uniprotkb:A8K795|ensembl:ENSP00000236957|ensembl:ENSP00000376055|ensembl:ENSP00000376056|ensembl:ENSP00000489993|ensembl:ENSP00000490214|ensembl:ENSP00000490326	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1b_human(display_long)|uniprotkb:EEF1B(gene name synonym)|uniprotkb:EF1B(gene name synonym)|uniprotkb:EEF1B2(gene name)|psi-mi:EEF1B2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032752.1|refseq:NP_001950.1|refseq:NP_066944.1|ensembl:ENSG00000114942(gene)|ensembl:ENSG00000283391(gene)|ensembl:ENST00000236957(transcript)|ensembl:ENST00000392221(transcript)|ensembl:ENST00000392222(transcript)|ensembl:ENST00000635728(transcript)|ensembl:ENST00000636275(transcript)|ensembl:ENST00000637253(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0045471"(response to ethanol)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219|interpro:IPR036282|mint:P24534|rcsb pdb:1B64|rcsb pdb:5DQS|reactome:R-HSA-156842	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:d4zkwQOMlpr6XBapMfT1sxy2ZPs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96EP5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2133162|uniprotkb:Q96MJ3|uniprotkb:Q9NRR9|ensembl:ENSP00000233078	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dazp1_human(display_long)|uniprotkb:DAZAP1(gene name)|psi-mi:DAZAP1(display_short)|uniprotkb:Deleted in azoospermia-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061832.2|refseq:NP_733829.1|ensembl:ENSG00000071626(gene)|ensembl:ENST00000233078(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034046"("poly(G) binding")|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034131|interpro:IPR034134|interpro:IPR035979|mint:Q96EP5|rcsb pdb:2DGS|rcsb pdb:2DH8	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4uZCZTXZGnZAD9tBcurmc8RhGwY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23528	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04632	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711828|uniprotkb:Q8WTX3|uniprotkb:Q96EW0|uniprotkb:A8K0P1|ensembl:ENSP00000246533|ensembl:ENSP00000464849	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpns1_human(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:CAPNS1(gene name)|psi-mi:CAPNS1(display_short)|uniprotkb:CAPN4(gene name synonym)|uniprotkb:CAPNS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000126247(gene)|ensembl:ENST00000246533(transcript)|ensembl:ENST00000588815(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|mint:P04632|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:4PHJ|rcsb pdb:4PHK|rcsb pdb:4PHM|rcsb pdb:4WQ2|rcsb pdb:4WQ3|rcsb pdb:5D69|rcsb pdb:6QLB|reactome:R-HSA-1474228|reactome:R-HSA-6809371|reactome:R-HSA-8862803|refseq:NP_001003962.1|refseq:NP_001740.1|refseq:NP_001289561.1|refseq:NP_001289562.1|refseq:XP_005259352.1|refseq:XP_005259353.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:siQugDvaWq0YjOr8qOCf0BsRRKs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92945	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049099|uniprotkb:O00301|uniprotkb:Q59EZ9|uniprotkb:Q5U4P6|uniprotkb:Q9UNT5|uniprotkb:Q9UQH5|intact:EBI-5455671|ensembl:ENSP00000381216	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp2_human(display_long)|uniprotkb:KH type-splicing regulatory protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:KHSRP(gene name)|psi-mi:KHSRP(display_short)|uniprotkb:FUBP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003676.2|ensembl:ENSG00000088247(gene)|ensembl:ENST00000398148(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q92945|rcsb pdb:2HH2|rcsb pdb:2HH3|rcsb pdb:2JVZ|rcsb pdb:2OPU|rcsb pdb:2OPV|rcsb pdb:4B8T|reactome:R-HSA-380994|reactome:R-HSA-450604|dip:DIP-48484N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hlybJllTqSgPgtwwz3kc12zDYh49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15785	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054499|uniprotkb:Q53GH9|uniprotkb:Q6IBN7|uniprotkb:Q9NTZ3|ensembl:ENSP00000361900	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tom34_human(display_long)|uniprotkb:URCC3(gene name synonym)|uniprotkb:Translocase of outer membrane 34 kDa subunit(gene name synonym)|uniprotkb:TOMM34(gene name)|psi-mi:TOMM34(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006800.2|ensembl:ENSG00000025772(gene)|ensembl:ENST00000372813(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:K0J5GQoRwg/7Yz0p2e41R1wQrME9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14974	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15149	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297903|intact:EBI-1103289|intact:EBI-1103265|intact:EBI-1055056|uniprotkb:Q15148|uniprotkb:Q16640|ensembl:ENSP00000323856|uniprotkb:Q6S376|intact:EBI-28976159|uniprotkb:Q6S380|intact:EBI-1103313|uniprotkb:Q6S377|uniprotkb:Q6S378|uniprotkb:Q6S379|intact:EBI-1103301|intact:EBI-1103253|uniprotkb:Q6S381|uniprotkb:Q6S382|uniprotkb:Q6S383|intact:EBI-2825763	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:plec_human(display_long)|uniprotkb:PLEC(gene name)|psi-mi:PLEC(display_short)|uniprotkb:Hemidesmosomal protein 1(gene name synonym)|uniprotkb:PLEC1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000178209(gene)|ensembl:ENST00000322810(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0120193"(tight junction organization)|go:"GO:2000689"(actomyosin contractile ring assembly actin filament organization)|go:"GO:2000983"(regulation of ATP citrate synthase activity)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR005326(Plectin/S10, N-terminal)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006997"(nucleus organization)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016569"(obsolete covalent chromatin modification)|go:"GO:0019226"(transmission of nerve impulse)|interpro:IPR030269|interpro:IPR035915|interpro:IPR018159|interpro:IPR036388|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q15149|rcsb pdb:1MB8|rcsb pdb:2N03|rcsb pdb:2ODU|rcsb pdb:2ODV|rcsb pdb:3F7P|rcsb pdb:3PDY|rcsb pdb:3PE0|rcsb pdb:4GDO|rcsb pdb:4Q58|rcsb pdb:4Q59|rcsb pdb:5J1F|rcsb pdb:5J1G|rcsb pdb:5J1H|rcsb pdb:5J1I|reactome:R-HSA-2022090|reactome:R-HSA-264870|reactome:R-HSA-446107|ensembl:ENST00000436759|ensembl:ENSP00000388180|ensembl:ENST00000527096|ensembl:ENSP00000434583|ensembl:ENSP00000323856|ensembl:ENST00000345136|ensembl:ENSP00000344848|ensembl:ENST00000354589|ensembl:ENSP00000346602|ensembl:ENST00000354958|ensembl:ENSP00000347044|ensembl:ENST00000356346|ensembl:ENSP00000348702|ensembl:ENST00000357649|ensembl:ENSP00000350277|ensembl:ENST00000398774|ensembl:ENSP00000381756|refseq:NP_000436.2|refseq:NP_958780.1|refseq:NP_958781.1|refseq:NP_958782.1|refseq:NP_958783.1|refseq:NP_958784.1|refseq:NP_958785.1|refseq:NP_958786.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zbctDAOOCaJUx3WBdp85v7SI0sI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60493	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727209|uniprotkb:Q4TT31|uniprotkb:O60718|uniprotkb:Q5JXJ7|uniprotkb:Q5JXJ8|uniprotkb:Q96AP9|uniprotkb:Q9C0J5|uniprotkb:Q9NU45|intact:EBI-1056609|uniprotkb:A8K0B1|uniprotkb:Q4TT29|uniprotkb:E1P5E4|uniprotkb:E1P5E5|ensembl:ENSP00000230085	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snx3_human(display_long)|uniprotkb:Protein SDP3(gene name synonym)|uniprotkb:SNX3(gene name)|psi-mi:SNX3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003786.1|refseq:NP_690040.1|refseq:NP_001287858.1|ensembl:ENSG00000112335(gene)|ensembl:ENST00000230085(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1905394"(retromer complex binding)|go:"GO:2000642"(negative regulation of early endosome to late endosome transport)|interpro:IPR001683(Phox-like)|interpro:IPR036871|interpro:IPR042137|rcsb pdb:2MXC|rcsb pdb:2YPS|rcsb pdb:5F0J|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:7BLO|reactome:R-HSA-3238698|reactome:R-HSA-5689880	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M/QKs79zhWobkEdFuxrJTnrrUes9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62826	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54920	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-749652|uniprotkb:Q96IK3|uniprotkb:Q9BVJ3|uniprotkb:A8K879|ensembl:ENSP00000263354	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snaa_human(display_long)|uniprotkb:N-ethylmaleimide-sensitive factor attachment protein alpha(gene name synonym)|uniprotkb:NAPA(gene name)|psi-mi:NAPA(display_short)|uniprotkb:SNAPA(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003818.2|ensembl:ENSG00000105402(gene)|ensembl:ENST00000263354(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005483"(soluble NSF attachment protein activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007420"(brain development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031201"(SNARE complex)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000744(NSF attachment protein)|interpro:IPR011990(Tetratricopeptide-like helical)|reactome:R-HSA-204005|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RHbBvhRSSaakY4HPkl3Y9ggkiPk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35908	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1247312|uniprotkb:Q4VAQ2|ensembl:ENSP00000310861	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k22e_human(display_long)|uniprotkb:KRT2(gene name)|psi-mi:KRT2(display_short)|uniprotkb:KRT2A(gene name synonym)|uniprotkb:KRT2E(gene name synonym)|uniprotkb:Cytokeratin-2e(gene name synonym)|uniprotkb:Keratin-2e(gene name synonym)|uniprotkb:Type-II keratin Kb2(gene name synonym)|uniprotkb:Keratin-2 epidermis(gene name synonym)|uniprotkb:Epithelial keratin-2e(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000414.2|ensembl:ENSG00000172867(gene)|ensembl:ENST00000309680(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0031424"(keratinization)|go:"GO:0032980"(keratinocyte activation)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P35908|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0051546"(keratinocyte migration)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T7LeB8nkZzNjUb8DWdkxbrl5f789606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92900	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373471|uniprotkb:O00239|uniprotkb:O43343|uniprotkb:Q86Z25|uniprotkb:Q92842|ensembl:ENSP00000470142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rent1_human(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:RENT1(gene name synonym)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002902.2|refseq:NP_001284478.1|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000599848(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q92900|rcsb pdb:2GJK|rcsb pdb:2GK6|rcsb pdb:2GK7|rcsb pdb:2IYK|rcsb pdb:2WJV|rcsb pdb:2WJY|rcsb pdb:2XZO|rcsb pdb:2XZP|rcsb pdb:6EJ5|rcsb pdb:6Z3R|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0006406"(mRNA export from nucleus)|dip:DIP-29875N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ORqXFPAa7qA8cwM5qcNodIF0q/s9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43405	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75369	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352089|intact:EBI-1754974|uniprotkb:Q13706|uniprotkb:Q59EC2|uniprotkb:Q6MZJ1|uniprotkb:Q8WXS9|uniprotkb:Q8WXT0|uniprotkb:Q8WXT1|uniprotkb:Q8WXT2|uniprotkb:Q9NRB5|uniprotkb:B2ZZ84|uniprotkb:Q9NT26|uniprotkb:Q9UEV9|intact:EBI-1960054|uniprotkb:C9JKE6|uniprotkb:B2ZZ85|uniprotkb:C9JMC4|ensembl:ENSP00000295956|uniprotkb:B2ZZ83|uniprotkb:Q60FE7|uniprotkb:Q8WXT3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flnb_human(display_long)|uniprotkb:FLNB(gene name)|psi-mi:FLNB(display_short)|uniprotkb:FLN1L(gene name synonym)|uniprotkb:FLN3(gene name synonym)|uniprotkb:TABP(gene name synonym)|uniprotkb:TAP(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Thyroid autoantigen(gene name synonym)|uniprotkb:Truncated actin-binding protein(gene name synonym)|uniprotkb:ABP-280 homolog(gene name synonym)|uniprotkb:ABP-278(gene name synonym)|uniprotkb:Filamin-3(gene name synonym)|uniprotkb:Filamin homolog 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001157791.1|refseq:NP_001448.2|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:O75369|rcsb pdb:2DI8|rcsb pdb:2DI9|rcsb pdb:2DIA|rcsb pdb:2DIB|rcsb pdb:2DIC|rcsb pdb:2DJ4|rcsb pdb:2DLG|rcsb pdb:2DMB|rcsb pdb:2DMC|rcsb pdb:2E9I|rcsb pdb:2E9J|rcsb pdb:2EE6|rcsb pdb:2EE9|rcsb pdb:2EEA|rcsb pdb:2EEB|rcsb pdb:2EEC|rcsb pdb:2EED|rcsb pdb:2WA5|rcsb pdb:2WA6|rcsb pdb:2WA7|rcsb pdb:3FER|rcsb pdb:4B7L|rcsb pdb:5DCP|reactome:R-HSA-1169408|ensembl:ENSG00000136068(gene)|ensembl:ENST00000295956(transcript)|go:"GO:0001725"(stress fiber)|refseq:NP_001157789.1|refseq:NP_001157790.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lsf6C/Vg0io7UhUi1Kapgwp0p5E9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62277	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351850|uniprotkb:P19116|uniprotkb:Q02546|uniprotkb:Q29200|uniprotkb:Q498Y0|uniprotkb:B2R549|ensembl:ENSP00000435777	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs13_human(display_long)|uniprotkb:RPS13(gene name)|psi-mi:RPS13(display_short)|uniprotkb:Small ribosomal subunit protein uS15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001008.1|ensembl:ENSG00000110700(gene)|ensembl:ENST00000525634(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000589(Ribosomal protein S15)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR012606(Ribosomal protein S13/S15, N-terminal)|interpro:IPR023029|mint:P62277|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6OM7|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GmlWYkXKxX6YwpEtzNABb+ZcytI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PAU2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189929|ensembl:ENSP00000482486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pau2_human(display_long)|uniprotkb:RAVER1(gene name)|psi-mi:RAVER1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000611074(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034633|interpro:IPR034635|interpro:IPR035979|ensembl:ENSG00000161847(gene)|refseq:NP_597709.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:R49B14TFxiQLK5QlLBcHyZQTKD09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BZX2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053938|uniprotkb:Q5VV91|uniprotkb:Q7KZV3|uniprotkb:Q92528|uniprotkb:Q96KG5|uniprotkb:Q9BU42|ensembl:ENSP00000356853|intact:EBI-21355463	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:uck2_human(display_long)|uniprotkb:Uridine monophosphokinase 2(gene name synonym)|uniprotkb:Cytidine monophosphokinase 2(gene name synonym)|uniprotkb:UCK2(gene name)|psi-mi:UCK2(display_short)|uniprotkb:Testis-specific protein TSA903(gene name synonym)|uniprotkb:UMPK(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036606.2|ensembl:ENSG00000143179(gene)|ensembl:ENST00000367879(transcript)|go:"GO:0004849"(uridine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044206"(UMP salvage)|go:"GO:0044211"(CTP salvage)|interpro:IPR000764(Uridine kinase)|interpro:IPR006083(Phosphoribulokinase/uridine kinase)|interpro:IPR027417|interpro:IPR029925|rcsb pdb:1UDW|rcsb pdb:1UEI|rcsb pdb:1UEJ|rcsb pdb:1UFQ|rcsb pdb:1UJ2|rcsb pdb:1XRJ|rcsb pdb:6N53|rcsb pdb:6N54|rcsb pdb:6N55|rcsb pdb:6PWZ|reactome:R-HSA-73614	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rk530GVV4ltYepCzVu5qVMYv5uI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52789	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-741469|uniprotkb:Q8WU87|uniprotkb:Q9UN82|ensembl:ENSP00000290573|uniprotkb:D6W5J2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hxk2_human(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Muscle form hexokinase(gene name synonym)|uniprotkb:HK2(gene name)|psi-mi:HK2(display_short)|uniprotkb:Hexokinase-B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|mint:P52789|rcsb pdb:2NZT|rcsb pdb:5HEX|rcsb pdb:5HFU|rcsb pdb:5HG1|reactome:R-HSA-70171|go:"GO:0008865"(fructokinase activity)|ensembl:ENSG00000159399(gene)|ensembl:ENST00000290573(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|refseq:NP_000180.2|dip:DIP-50110N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:99w5KbKmsqMoorQz/wot6z6t2WM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050760|uniprotkb:Q53RW7|uniprotkb:Q6URK5|uniprotkb:D3DPF4|ensembl:ENSP00000376309|ensembl:ENSP00000416340|ensembl:ENSP00000503593|ensembl:ENSP00000504135|ensembl:ENSP00000504152	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa3_human(display_long)|uniprotkb:HNRPA3(gene name synonym)|uniprotkb:HNRNPA3(gene name)|psi-mi:HNRNPA3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_919223.1|refseq:NP_001317178.1|ensembl:ENSG00000170144(gene)|ensembl:ENST00000392524(transcript)|ensembl:ENST00000435711(transcript)|ensembl:ENST00000676629(transcript)|ensembl:ENST00000678111(transcript)|ensembl:ENST00000679159(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0051028"(mRNA transport)|go:"GO:0051033"(RNA transmembrane transporter activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034513|interpro:IPR034516|interpro:IPR035979|mint:P51991|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bbg0nIdhEHomcwtgZhT2yHy7+nU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95373	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50570	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P29692	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358607|uniprotkb:Q969J1|uniprotkb:D3DWK3|intact:EBI-748782|uniprotkb:Q96I38|ensembl:ENSP00000317399|ensembl:ENSP00000378551|ensembl:ENSP00000388261|ensembl:ENSP00000433412|ensembl:ENSP00000433611|ensembl:ENSP00000434448|ensembl:ENSP00000434872|ensembl:ENSP00000436542|ensembl:ENSP00000436933|ensembl:ENSP00000478340|ensembl:ENSP00000479653|ensembl:ENSP00000483527|ensembl:ENSP00000487680|intact:EBI-11048966|uniprotkb:Q4VBZ6|uniprotkb:B4DDU4|uniprotkb:E9PBQ9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1d_human(display_long)|uniprotkb:EEF1D(gene name)|psi-mi:EEF1D(display_short)|uniprotkb:EF1D(gene name synonym)|uniprotkb:Antigen NY-CO-4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001123528.1|refseq:NP_001123527.1|refseq:NP_001123529.1|refseq:NP_001951.2|refseq:XP_011515207.1|refseq:XP_011515208.1|ensembl:ENST00000419152(transcript)|ensembl:ENST00000529272(transcript)|ensembl:ENST00000530191(transcript)|ensembl:ENST00000530445(transcript)|ensembl:ENST00000531218(transcript)|ensembl:ENST00000533494(transcript)|ensembl:ENST00000534380(transcript)|ensembl:ENST00000614575(transcript)|ensembl:ENST00000615067(transcript)|ensembl:ENST00000615698(transcript)|ensembl:ENST00000632587(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010941"(regulation of cell death)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045296"(cadherin binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219|mint:P29692|rcsb pdb:2MVM|rcsb pdb:2MVN|rcsb pdb:2N51|rcsb pdb:5JPO|reactome:R-HSA-156842|ensembl:ENSG00000104529(gene)|ensembl:ENSG00000273594(gene)|ensembl:ENST00000317198(transcript)|ensembl:ENST00000395119(transcript)|refseq:NP_001304672.1|refseq:NP_001182132.1|refseq:NP_001276879.1|refseq:XP_006716585.1|refseq:XP_006716586.1|refseq:XP_006716587.1|refseq:XP_006716588.1|refseq:XP_005250880.1|refseq:NP_001317575.1|refseq:XP_016868659.1|refseq:NP_001123525.2|refseq:NP_115754.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9Mzpfofeg2W/GQ/JfjFxcCFJnKg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355720|uniprotkb:Q6IB85|uniprotkb:Q6NE84|ensembl:ENSP00000300291	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cpsf5_human(display_long)|uniprotkb:NUDT21(gene name)|psi-mi:NUDT21(display_short)|uniprotkb:CFIM25(gene name synonym)|uniprotkb:CPSF25(gene name synonym)|uniprotkb:CPSF5(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 25 kDa subunit(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 21(gene name synonym)|uniprotkb:Cleavage factor Im complex 25 kDa subunit(gene name synonym)|uniprotkb:Nudix hydrolase 21(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 68 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_008937.1|ensembl:ENSG00000167005(gene)|ensembl:ENST00000300291(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006397"(mRNA processing)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031439"(positive regulation of mRNA cleavage)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2000975"(positive regulation of pro-B cell differentiation)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR016706(Cleavage and polyadenylation specificity factor, 25 kDa subunit)|mint:O43809|rcsb pdb:2CL3|rcsb pdb:2J8Q|rcsb pdb:3BAP|rcsb pdb:3BHO|rcsb pdb:3MDG|rcsb pdb:3MDI|rcsb pdb:3N9U|rcsb pdb:3P5T|rcsb pdb:3P6Y|rcsb pdb:3Q2S|rcsb pdb:3Q2T|rcsb pdb:5R4P|rcsb pdb:5R4Q|rcsb pdb:5R4R|rcsb pdb:5R4S|rcsb pdb:5R4T|rcsb pdb:5R4U|rcsb pdb:5R64|rcsb pdb:5R65|rcsb pdb:5R66|rcsb pdb:5R67|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|dip:DIP-42502N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Acad4mYVuS+Eox+X2CH8PYUkGAA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60228	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:s09LicCa0mb9WwO7esZvVdvUonY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43488	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748855|uniprotkb:O75749|uniprotkb:Q5TG63|ensembl:ENSP00000235835	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ark72_human(display_long)|uniprotkb:AFB1 aldehyde reductase 1(gene name synonym)|uniprotkb:Aldoketoreductase 7(gene name synonym)|uniprotkb:AKR7A2(gene name)|psi-mi:AKR7A2(display_short)|uniprotkb:AFAR(gene name synonym)|uniprotkb:AFAR1(gene name synonym)|uniprotkb:AKR7(gene name synonym)|uniprotkb:Succinic semialdehyde reductase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003680.2|ensembl:ENSG00000053371(gene)|ensembl:ENST00000235835(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0019119"(phenanthrene-9,10-epoxide hydrolase activity)|go:"GO:0044597"(daunorubicin metabolic process)|go:"GO:0044598"(doxorubicin metabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR023210|interpro:IPR036812|rcsb pdb:2BP1|reactome:R-HSA-5423646	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HUJHFlZOl/Xb03VzAZAcmsEHK9o9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96PU8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-945792|uniprotkb:Q2I375|uniprotkb:Q5MJQ1|uniprotkb:Q969L9|uniprotkb:Q96EJ3|uniprotkb:Q96KA3|uniprotkb:Q96PU6|uniprotkb:Q96PU7|uniprotkb:Q9P0X6|uniprotkb:Q9P0X7|uniprotkb:Q9P0X8|uniprotkb:Q9P0X9|uniprotkb:Q9P0Y0|uniprotkb:Q9P0Y1|ensembl:ENSP00000355094	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:qki_human(display_long)|uniprotkb:QKI(gene name)|psi-mi:QKI(display_short)|uniprotkb:HKQ(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006766.1|refseq:NP_996735.1|refseq:NP_996736.1|refseq:NP_996737.1|refseq:NP_001288014.1|refseq:XP_011534561.1|ensembl:ENSG00000112531(gene)|ensembl:ENST00000361752(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0007286"(spermatid development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042552"(myelination)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0045202"(synapse)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032367|interpro:IPR032377|interpro:IPR036612|mint:Q96PU8|rcsb pdb:4JVH|reactome:R-HSA-6802952	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7dcw5OyNAhQTE+yTch3qbSlZJdE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B1AKQ8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190833|ensembl:ENSP00000416651	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b1akq8_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000078369(gene)|ensembl:ENST00000437146(transcript)|go:"GO:0007165"(signal transduction)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR036322	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BUB/7mf+WlDyk4rDXHXUrW9rKWE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15181	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712298|ensembl:ENSP00000362329|uniprotkb:Q2M348|uniprotkb:Q5SQT7|uniprotkb:Q6P7P4|uniprotkb:Q9UQJ5|uniprotkb:Q9Y5B1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipyr_human(display_long)|uniprotkb:Pyrophosphate phospho-hydrolase(gene name synonym)|uniprotkb:PPA1(gene name)|psi-mi:PPA1(display_short)|uniprotkb:IOPPP(gene name synonym)|uniprotkb:PP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000180817(gene)|ensembl:ENST00000373232(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008162(Inorganic pyrophosphatase)|interpro:IPR036649|mint:Q15181|rcsb pdb:6C45|rcsb pdb:7BTN|rcsb pdb:7CMO|reactome:R-HSA-379716|reactome:R-HSA-71737|refseq:NP_066952.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1094gn9aeisgfDUhIroRn2iqom49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NR30	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357942|uniprotkb:Q13436|uniprotkb:Q5VX41|uniprotkb:Q68D35|uniprotkb:B2RDL0|intact:EBI-2555822|ensembl:ENSP00000346120	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx21_human(display_long)|uniprotkb:DDX21(gene name)|psi-mi:DDX21(display_short)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004719.2|dip:DIP-32941N|refseq:NP_001243839.1|ensembl:ENSG00000165732(gene)|ensembl:ENST00000354185(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9NR30|rcsb pdb:2M3D|rcsb pdb:6L5L|rcsb pdb:6L5M|rcsb pdb:6L5N|rcsb pdb:6L5O|reactome:R-HSA-5250924|reactome:R-HSA-6791226|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NSmxvs3DBWvKpVDEAHIpqy7/b6w9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02538	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21333	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14160	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357345|uniprotkb:Q6P496|uniprotkb:Q7Z5D1|uniprotkb:Q8WWV8|uniprotkb:Q96C69|uniprotkb:Q96GG1|ensembl:ENSP00000322938|ensembl:ENSP00000349486|ensembl:ENSP00000366756	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:scrib_human(display_long)|uniprotkb:SCRIB(gene name)|psi-mi:SCRIB(display_short)|uniprotkb:CRIB1(gene name synonym)|uniprotkb:KIAA0147(gene name synonym)|uniprotkb:LAP4(gene name synonym)|uniprotkb:SCRB1(gene name synonym)|uniprotkb:VARTUL(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056171.3|refseq:NP_874365.3|dip:DIP-31259N|ensembl:ENSG00000180900(gene)|ensembl:ENST00000320476(transcript)|ensembl:ENST00000356994(transcript)|ensembl:ENST00000377533(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q14160|rcsb pdb:1UJU|rcsb pdb:1WHA|rcsb pdb:1X5Q|rcsb pdb:2W4F|rcsb pdb:4WYT|rcsb pdb:4WYU|rcsb pdb:5VWC|rcsb pdb:5VWI|rcsb pdb:5VWK|rcsb pdb:6EEY|rcsb pdb:6ESP|rcsb pdb:6MS1|rcsb pdb:6MTU|rcsb pdb:6MTV|rcsb pdb:6MYE|rcsb pdb:6MYF|rcsb pdb:6XA6|rcsb pdb:6XA7|rcsb pdb:6XA8|rcsb pdb:7JO7|reactome:R-HSA-4608870|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y4lIQ2NivmndHYd/JXSKvU2jv+w9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62280	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047710|uniprotkb:B2R4F5|uniprotkb:P04643|uniprotkb:Q498Y6|uniprotkb:Q6IRY0|ensembl:ENSP00000270625	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs11_human(display_long)|uniprotkb:RPS11(gene name)|psi-mi:RPS11(display_short)|uniprotkb:Small ribosomal subunit protein uS17(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001006.1|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000266(Ribosomal protein S17)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019979|interpro:IPR028333|interpro:IPR032440|mint:P62280|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|go:"GO:0005840"(ribosome)|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|ensembl:ENSG00000142534(gene)|ensembl:ENST00000270625(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6OM0|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0fqJjtWAuz31VTKt2mbteRoi8vA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13010	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19320	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69891	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056789|uniprotkb:P02096|uniprotkb:P62027|uniprotkb:Q96FH7|uniprotkb:Q8TDA1|uniprotkb:Q549G1|ensembl:ENSP00000327431	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg1_human(display_long)|uniprotkb:HBG1(gene name)|psi-mi:HBG1(display_short)|uniprotkb:Hemoglobin gamma-1 chain(gene name synonym)|uniprotkb:Gamma-1-globin(gene name synonym)|uniprotkb:Hemoglobin gamma-A chain(gene name synonym)|uniprotkb:Hb F Agamma(gene name synonym)|uniprotkb:PRO2979(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000550.2|ensembl:ENSG00000213934(gene)|ensembl:ENST00000330597(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1I3D|rcsb pdb:1I3E|reactome:R-HSA-983231	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iJ4HIirEDw3t7jxBcbZLma4HgXE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y262	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26583	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057009|uniprotkb:Q5U072|uniprotkb:D3DP37|uniprotkb:B2R4K8|ensembl:ENSP00000296503|ensembl:ENSP00000393448|ensembl:ENSP00000404912	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmgb2_human(display_long)|uniprotkb:HMGB2(gene name)|psi-mi:HMGB2(display_short)|uniprotkb:HMG2(gene name synonym)|uniprotkb:High mobility group protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001124160.1|refseq:NP_001124161.1|refseq:NP_002120.1|ensembl:ENSG00000164104(gene)|ensembl:ENST00000296503(transcript)|ensembl:ENST00000438704(transcript)|ensembl:ENST00000446922(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032075"(positive regulation of nuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042056"(chemoattractant activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044378"(non-sequence-specific DNA binding, bending)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR036910|mint:P26583|reactome:R-HSA-140342	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ACzaSeIwT3vM4ZgpCSSlzA6nd4U9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11142	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09496	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78527	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26641	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12956	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:C9JNW5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190023|ensembl:ENSP00000420380	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c9jnw5_human(display_long)|uniprotkb:RPL24(gene name)|psi-mi:RPL24(display_short)|uniprotkb:hCG_2023003(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114391(gene)|ensembl:ENST00000469605(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|interpro:IPR000988(Ribosomal protein L24e)|interpro:IPR011017(TRASH)|interpro:IPR023442|interpro:IPR038630	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OE53tm5RMpxZtGwHcVKogk9J89A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02790	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62906	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356860|uniprotkb:P52859|uniprotkb:P53025|uniprotkb:Q5TZT6|uniprotkb:Q8J013|uniprotkb:B2R801|ensembl:ENSP00000363018	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl10a_human(display_long)|uniprotkb:RPL10A(gene name)|psi-mi:RPL10A(display_short)|uniprotkb:NEDD6(gene name synonym)|uniprotkb:CSA-19(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 6(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009035.3|ensembl:ENSG00000198755(gene)|ensembl:ENST00000322203(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673|interpro:IPR023674|interpro:IPR028364|mint:P62906|rcsb pdb:4UG0|rcsb pdb:4V6X|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LU8|rcsb pdb:6OLG|rcsb pdb:6QZP|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wrXKX6vzZ3ovXP3yUoL1/r+NGiw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8IWZ3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359558|ensembl:ENSP00000354085|intact:EBI-948598|uniprotkb:A6NH85|uniprotkb:Q149P2|uniprotkb:Q8IWZ2|uniprotkb:Q8WY90|uniprotkb:Q96G77|uniprotkb:Q96GK0|uniprotkb:Q9H2U0|uniprotkb:Q9HA95|uniprotkb:Q9NWG4|uniprotkb:Q9UPR7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ankh1_human(display_long)|uniprotkb:Multiple ankyrin repeats single KH domain(gene name synonym)|uniprotkb:ANKHD1(gene name)|psi-mi:ANKHD1(display_short)|uniprotkb:HIV-1 Vpr-binding ankyrin repeat protein(gene name synonym)|uniprotkb:KIAA1085(gene name synonym)|uniprotkb:MASK(gene name synonym)|uniprotkb:VBARP(gene name synonym)|uniprotkb:PP2500(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000131503(gene)|ensembl:ENST00000360839(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|refseq:NP_001183959.1|refseq:NP_060217.1|refseq:NP_060448.1|refseq:NP_078944.2|refseq:NP_065741.3|ensembl:ENSP00000354085|ensembl:ENST00000394722|ensembl:ENSP00000378211|ensembl:ENST00000394723|ensembl:ENSP00000378212|ensembl:ENST00000616482|ensembl:ENSP00000478529|dip:DIP-36371N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yPjTR77ttPwAEMg8WHOzYJNcAhA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13310	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372844|uniprotkb:Q6P0N3|uniprotkb:B1ANQ8|ensembl:ENSP00000361948|intact:EBI-877641|uniprotkb:Q4VC03	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pabp4_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:APP1(gene name synonym)|uniprotkb:PABP4(gene name synonym)|uniprotkb:"Inducible poly(A)-binding protein"(gene name synonym)|uniprotkb:Activated-platelet protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129126.1|refseq:NP_003810.1|ensembl:ENSG00000090621(gene)|ensembl:ENST00000372857(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006412"(translation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0061515"(myeloid cell development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q13310|refseq:NP_001129125.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u1qCM3o5X7jLIa1vyqFCIH7v01w9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43395	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UBQ5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09668	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189940|ensembl:ENSP00000220166|uniprotkb:B2RBK0|uniprotkb:Q96NY6|uniprotkb:Q9BUM7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cath_human(display_long)|uniprotkb:CTSH(gene name)|psi-mi:CTSH(display_short)|uniprotkb:CPSB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000103811(gene)|ensembl:ENST00000220166(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002764"(immune response-regulating signaling pathway)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060448"(dichotomous subdivision of terminal units involved in lung branching)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0097486"(multivesicular body lumen)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010813"(neuropeptide catabolic process)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030108"(HLA-A specific activating MHC class I receptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031638"(zymogen activation)|go:"GO:0031648"(protein destabilization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0005764"(lysosome)|interpro:IPR039417|rcsb pdb:1BZN|rcsb pdb:6CZK|rcsb pdb:6CZS|reactome:R-HSA-2132295|reactome:R-HSA-5683826|reactome:R-HSA-6798695|interpro:IPR038765|refseq:NP_004381.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tY1fBEZEkMs5w45HHaK5LVO574Q9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54819	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P68032	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352273|uniprotkb:P04270|ensembl:ENSP00000290378	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:actc_human(display_long)|uniprotkb:ACTC1(gene name)|psi-mi:ACTC1(display_short)|uniprotkb:ACTC(gene name synonym)|uniprotkb:Alpha-cardiac actin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005150.1|ensembl:ENSG00000159251(gene)|ensembl:ENST00000290378(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0033275"(actin-myosin filament sliding)|go:"GO:0042493"|go:"GO:0044297"(cell body)|go:"GO:0045471"(response to ethanol)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68032|reactome:R-HSA-390522|reactome:R-HSA-8980692|reactome:R-HSA-9013026	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:U/lKYqWUWMSC3fBHFaAcgzfk+3w9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96AG4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358888|uniprotkb:Q9P189|uniprotkb:D3DTX8|ensembl:ENSP00000225972|uniprotkb:B2RE83	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lrc59_human(display_long)|uniprotkb:LRRC59(gene name)|psi-mi:LRRC59(display_short)|uniprotkb:Ribosome-binding protein p34(gene name synonym)|uniprotkb:PRO1855(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060979.2|ensembl:ENSG00000108829(gene)|ensembl:ENST00000225972(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045296"(cadherin binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q96AG4	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gAtWed9Jv69oHdkEFgpWGFnvcWE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30050	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352743|uniprotkb:Q6PB27|uniprotkb:Q5VVV2|ensembl:ENSP00000354739	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl12_human(display_long)|uniprotkb:RPL12(gene name)|psi-mi:RPL12(display_short)|uniprotkb:Large ribosomal subunit protein uL11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000967.1|ensembl:ENSG00000197958(gene)|ensembl:ENST00000361436(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P30050|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TNPEtl60cILofaPzUznvZiw6D7E9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4DX78	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4dx78_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:w8STRlDtOptPq7bILJWhcRV5g5E9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39656	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358866|uniprotkb:O43244|uniprotkb:Q8NI93|uniprotkb:Q9BUI2|uniprotkb:B2RDQ4|uniprotkb:Q5VWA5|ensembl:ENSP00000399457|uniprotkb:B4DJE3|uniprotkb:B4DLI2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ost48_human(display_long)|uniprotkb:DDOST(gene name)|psi-mi:DDOST(display_short)|uniprotkb:KIAA0115(gene name synonym)|uniprotkb:OST48(gene name synonym)|uniprotkb:OK/SW-cl.45(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005207.2|ensembl:ENSG00000244038(gene)|ensembl:ENST00000415136(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:P39656|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-9694548	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:utOlgvpqe2JHEJHk4gIp8tXwv/I9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15942	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-444225|ensembl:ENSP00000324422|ensembl:ENSP00000494798|uniprotkb:Q6I9S4|uniprotkb:A4D2G6|uniprotkb:B4DQX7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:zyx_human(display_long)|uniprotkb:Zyxin-2(gene name synonym)|uniprotkb:ZYX(gene name)|psi-mi:ZYX(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000159840(gene)|ensembl:ENSG00000285443(gene)|ensembl:ENST00000322764(transcript)|ensembl:ENST00000646695(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001781(Zinc finger, LIM-type)|go:"GO:0043149"(stress fiber assembly)|refseq:NP_001010972.1|refseq:NP_003452.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4UC6NVZHDUrTy4sPhz7e7RpPwho9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31946	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BYB4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190293|ensembl:ENSP00000331313|ensembl:ENSP00000385154|uniprotkb:Q9H2S2|uniprotkb:Q9H4M4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gnb1l_human(display_long)|uniprotkb:GNB1L(gene name)|psi-mi:GNB1L(display_short)|uniprotkb:GY2(gene name synonym)|uniprotkb:KIAA1645(gene name synonym)|uniprotkb:WDR14(gene name synonym)|uniprotkb:DGCRK3(gene name synonym)|uniprotkb:WD repeat-containing protein 14(gene name synonym)|uniprotkb:WD40 repeat-containing protein deleted in VCFS(gene name synonym)|uniprotkb:FKSG1(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensembl:ENSG00000185838(gene)|ensembl:ENST00000329517(transcript)|ensembl:ENST00000403325(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_443730.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:txIUhYulfQGg1ly2Kgj27FNf+9U9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y520	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2685847|uniprotkb:Q05DM8|uniprotkb:Q9HA05|uniprotkb:Q9UF29|uniprotkb:Q9NSM8|uniprotkb:Q9H2N2|uniprotkb:Q9NXL3|uniprotkb:Q6PD54|uniprotkb:Q49A39|uniprotkb:Q9UPQ6|intact:EBI-2824421	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prc2c_human(display_long)|uniprotkb:BAT2D1(gene name synonym)|uniprotkb:KIAA1096(gene name synonym)|uniprotkb:XTP2(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HBV X-transactivated gene 2 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 2(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:PRRC2C(gene name)|psi-mi:PRRC2C(display_short)|uniprotkb:BAT2L2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055987.2|refseq:XP_006711301.1|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|ensembl:ENST00000338920|ensembl:ENSP00000343629|ensembl:ENSG00000117523|ensembl:ENST00000426496|ensembl:ENSP00000410219|ensembl:ENST00000647382|ensembl:ENSP00000495867|refseq:XP_005245074.1|dip:DIP-47285N|mint:Q9Y520	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qecMuJHnm8n95OFpT+m+i9JbBoo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61221	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16698	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2554876|uniprotkb:B7Z6B8|uniprotkb:Q93085|uniprotkb:Q2M304|ensembl:ENSP00000220764|intact:EBI-10969978	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:decr_human(display_long)|uniprotkb:DECR(gene name synonym)|uniprotkb:2,4-dienoyl-CoA reductase [NADPH](gene name synonym)|uniprotkb:DECR1(gene name)|psi-mi:DECR1(display_short)|uniprotkb:SDR18C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 18C member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001350.1|ensembl:ENSG00000104325(gene)|ensembl:ENST00000220764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008670"("2,4-dienoyl-CoA reductase (NADPH) activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0070402"(NADPH binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902494"(catalytic complex)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|mint:Q16698|rcsb pdb:1W6U|rcsb pdb:1W73|rcsb pdb:1W8D|reactome:R-HSA-77288|interpro:IPR036291|refseq:NP_001317504.1|refseq:XP_016868636.1|refseq:XP_016868637.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l/8jxdd4pqUIUV2eIThvXTd66yE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27635	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352398|uniprotkb:A3KQT0|uniprotkb:Q16470|uniprotkb:Q2HXT7|uniprotkb:Q53FH7|uniprotkb:Q6FGN8|uniprotkb:Q8TDA5|intact:EBI-3046680|uniprotkb:D3DWW6|ensembl:ENSP00000341730|ensembl:ENSP00000358832	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl10_human(display_long)|uniprotkb:RPL10(gene name)|psi-mi:RPL10(display_short)|uniprotkb:QM(gene name synonym)|uniprotkb:Protein QM(gene name synonym)|uniprotkb:Tumor suppressor QM(gene name synonym)|uniprotkb:Laminin receptor homolog(gene name synonym)|uniprotkb:DXS648E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL16(gene name synonym)|uniprotkb:Ribosomal protein L10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243506.2|refseq:NP_001243509.2|refseq:NP_001290553.1|refseq:NP_001290554.1|refseq:NP_001290555.1|ensembl:ENSG00000147403(gene)|ensembl:ENST00000344746(transcript)|ensembl:ENST00000369817(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|refseq:NP_006004.3|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001197(Ribosomal protein L10e)|interpro:IPR016180(Ribosomal protein L10e/L16)|interpro:IPR018255|interpro:IPR036920|mint:P27635|rcsb pdb:2PA2|rcsb pdb:5AJ0|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6W6L|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|go:"GO:0016020"(membrane)|reactome:R-HSA-975957|dip:DIP-1133N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wJnBcv39yvVz2CaZq8UKgxIpJeE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P69892	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3910089|uniprotkb:A8MZE0|uniprotkb:P02096|uniprotkb:Q14491|uniprotkb:Q68NH9|uniprotkb:Q96FH6|uniprotkb:P62027|uniprotkb:Q96FH7|ensembl:ENSP00000338082	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg2_human(display_long)|uniprotkb:HBG2(gene name)|psi-mi:HBG2(display_short)|uniprotkb:Gamma-2-globin(gene name synonym)|uniprotkb:Hb F Ggamma(gene name synonym)|uniprotkb:Hemoglobin gamma-2 chain(gene name synonym)|uniprotkb:Hemoglobin gamma-G chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000175.1|ensembl:ENSG00000196565(gene)|ensembl:ENST00000336906(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1FDH|rcsb pdb:4MQJ|rcsb pdb:4MQK|reactome:R-HSA-983231|interpro:IPR002337(Haemoglobin, beta)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nhCM/lc1Dqw+ZTSHjiiyHcJIobk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11940	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XudTSPq2h9ckKAc48X88RVafPRU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049228|uniprotkb:P78493|uniprotkb:P78494|uniprotkb:Q15364|uniprotkb:Q15686|uniprotkb:Q15687|uniprotkb:Q15689|uniprotkb:Q99377|uniprotkb:Q9UE45|uniprotkb:Q9UE46|uniprotkb:Q9UE47|uniprotkb:Q9UE48|uniprotkb:Q9UFQ6|intact:EBI-3190943|uniprotkb:B3KUA3|ensembl:ENSP00000472998	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ru17_human(display_long)|uniprotkb:SNRNP70(gene name)|psi-mi:SNRNP70(display_short)|uniprotkb:RPU1(gene name synonym)|uniprotkb:U1AP1(gene name synonym)|uniprotkb:RNPU1Z(gene name synonym)|uniprotkb:SNRP70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003080.2|refseq:NP_001287998.1|ensembl:ENSG00000104852(gene)|ensembl:ENST00000598441(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005685"(U1 snRNP)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR022023|interpro:IPR034143|interpro:IPR035979|mint:P08621|rcsb pdb:2L5I|rcsb pdb:2L5J|rcsb pdb:3CW1|rcsb pdb:3PGW|rcsb pdb:4PJO|rcsb pdb:4PKD|rcsb pdb:6QX9|rcsb pdb:7B0Y|reactome:R-HSA-72163|dip:DIP-29406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/P72B69q5f0TX4vTr4GuRrtgiRM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62244	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347895|ensembl:ENSP00000318646|ensembl:ENSP00000457000|ensembl:ENSP00000458115|ensembl:ENSP00000458528|uniprotkb:P39027|uniprotkb:P39031|uniprotkb:Q3MHD9|uniprotkb:Q8C023|uniprotkb:Q9BV24	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs15a_human(display_long)|uniprotkb:RPS15A(gene name)|psi-mi:RPS15A(display_short)|uniprotkb:Small ribosomal subunit protein uS8(gene name synonym)|uniprotkb:OK/SW-cl.82(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134419(gene)|ensembl:ENST00000322989(transcript)|ensembl:ENST00000563390(transcript)|ensembl:ENST00000565420(transcript)|ensembl:ENST00000572008(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045787"(positive regulation of cell cycle)|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6G4W|interpro:IPR000630(Ribosomal protein S8)|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|interpro:IPR035987|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|mint:P62244|rcsb pdb:4UG0|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:4V6X|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-72695|reactome:R-HSA-975957|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZM7|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|refseq:NP_001010.2|refseq:NP_001025180.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Qdnhk7yvoFFYcRq5kEi7GQILaxs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P43243	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352602|ensembl:ENSP00000378284|ensembl:ENSP00000482895|uniprotkb:Q9UHW0|uniprotkb:Q9UQ27|uniprotkb:D3DQC3|uniprotkb:B7ZAV5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:matr3_human(display_long)|uniprotkb:KIAA0723(gene name synonym)|uniprotkb:MATR3(gene name)|psi-mi:MATR3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000015479(gene)|ensembl:ENST00000394805(transcript)|ensembl:ENST00000618441(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:P43243|refseq:NP_001181883.1|refseq:NP_001181884.1|refseq:NP_061322.2|refseq:NP_954659.1|refseq:NP_001181885.1|refseq:NP_001269207.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3UZlyCZHgdr1SBgUctv9Ev7XBSQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13347	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354047|intact:EBI-11759480|ensembl:ENSP00000504034|ensembl:ENSP00000504061|ensembl:ENSP00000502867|ensembl:ENSP00000503348|ensembl:ENSP00000503539	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3i_human(display_long)|uniprotkb:EIF3I(gene name)|psi-mi:EIF3I(display_short)|uniprotkb:TRIP1(gene name synonym)|uniprotkb:EIF3S2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 2(gene name synonym)|uniprotkb:eIF-3-beta(gene name synonym)|uniprotkb:eIF3 p36(gene name synonym)|uniprotkb:TGF-beta receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003748.1|ensembl:ENST00000676801(transcript)|ensembl:ENST00000677202(transcript)|ensembl:ENST00000677701(transcript)|ensembl:ENST00000677711(transcript)|ensembl:ENST00000677760(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|ensembl:ENSG00000084623(gene)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027525|interpro:IPR036322|mint:Q13347|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31116N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fogC6nSNmIynV2ziHZboT9laA3M9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07339	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2115097|uniprotkb:Q6IB57|ensembl:ENSP00000236671	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:catd_human(display_long)|uniprotkb:CTSD(gene name)|psi-mi:CTSD(display_short)|uniprotkb:CPSD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001900.1|dip:DIP-43906N|ensembl:ENSG00000117984(gene)|ensembl:ENST00000236671(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033144|mint:P07339|rcsb pdb:1LYA|rcsb pdb:1LYB|rcsb pdb:1LYW|rcsb pdb:4OBZ|rcsb pdb:4OC6|rcsb pdb:4OD9|reactome:R-HSA-1442490|reactome:R-HSA-2022377|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-9018519	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M1qLQBlL2DSCZiAwIPee9Vza3dU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P2J5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356077|uniprotkb:Q9NSE1|uniprotkb:A2RRR4|uniprotkb:B4DJ10|uniprotkb:Q2TU79|uniprotkb:A7E266|ensembl:ENSP00000377954	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sylc_human(display_long)|uniprotkb:LARS1(gene name)|psi-mi:LARS1(display_short)|uniprotkb:KIAA1352(gene name synonym)|uniprotkb:LARS(gene name synonym)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_064502.9|refseq:NP_001304893.1|refseq:NP_001304894.1|refseq:NP_057544.2|refseq:XP_011535958.1|ensembl:ENSG00000133706(gene)|ensembl:ENST00000394434(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0012505"(endomembrane system)|go:"GO:0016604"(nuclear body)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|mint:Q9P2J5|rcsb pdb:2WFD|rcsb pdb:6KID|rcsb pdb:6KIE|rcsb pdb:6KQY|rcsb pdb:6KR7|rcsb pdb:6LPF|rcsb pdb:6LR6|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nlK4kRCik2LLC3VNl0sryrLLnqA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99798	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2932893|ensembl:ENSP00000216254|uniprotkb:O75809|uniprotkb:Q5JZ41|uniprotkb:Q6FHX0|uniprotkb:Q8TAQ6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:acon_human(display_long)|uniprotkb:ACO2(gene name)|psi-mi:ACO2(display_short)|uniprotkb:Citrate hydro-lyase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100412(gene)|ensembl:ENST00000216254(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003994"(aconitate hydratase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0035900"(response to isolation stress)|go:"GO:0047780"(citrate dehydratase activity)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000573(Aconitase A/isopropylmalate dehydratase small subunit, swivel)|interpro:IPR001030(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha)|interpro:IPR006248(Aconitase, mitochondrial-like)|interpro:IPR015928(Aconitase/3-isopropylmalate dehydratase, swivel)|interpro:IPR015932(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2)|interpro:IPR018136|interpro:IPR036008|mint:Q99798|reactome:R-HSA-1268020|reactome:R-HSA-71403|interpro:IPR015931(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomains 1 and 3)|refseq:NP_001089.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QpDlGJHSwqfCktMlwYXKTonXftA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75146	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14671	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-948453|ensembl:ENSP00000257075|uniprotkb:Q5VXY7|uniprotkb:Q9HAN1|intact:EBI-2842591|uniprotkb:E9PCJ0|uniprotkb:Q53HH5|uniprotkb:B4DG92|uniprotkb:A8K6W4|uniprotkb:D3DPN3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pum1_human(display_long)|uniprotkb:PUM1(gene name)|psi-mi:PUM1(display_short)|uniprotkb:KIAA0099(gene name synonym)|uniprotkb:PUMH1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000134644(gene)|ensembl:ENST00000257075(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048863"(stem cell differentiation)|interpro:IPR033712|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0061157"(mRNA destabilization)|mint:Q14671|rcsb pdb:1IB2|rcsb pdb:1M8W|rcsb pdb:1M8X|rcsb pdb:1M8Y|rcsb pdb:1M8Z|rcsb pdb:2YJY|rcsb pdb:3BSB|rcsb pdb:3BSX|rcsb pdb:3Q0L|rcsb pdb:3Q0M|rcsb pdb:3Q0N|rcsb pdb:3Q0O|rcsb pdb:3Q0P|rcsb pdb:5YKH|rcsb pdb:5YKI|reactome:R-HSA-432722|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001313(Pumilio RNA-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033133|refseq:NP_001018494.1|refseq:NP_055491.1|dip:DIP-29082N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tGsSgrvQ/Ehnm3UC5IO4CHhCrFs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14204	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10809	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NVP1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724378|ensembl:ENSP00000263239|uniprotkb:Q6GTZ9|uniprotkb:Q6IAU4|uniprotkb:Q92732|uniprotkb:Q9BQB7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx18_human(display_long)|uniprotkb:DEAD box protein 18(gene name synonym)|uniprotkb:Myc-regulated DEAD box protein(gene name synonym)|uniprotkb:DDX18(gene name)|psi-mi:DDX18(display_short)|uniprotkb:cPERP-D(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006764.3|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR025313|interpro:IPR027417|interpro:IPR044773|mint:Q9NVP1|rcsb pdb:3LY5|ensembl:ENSG00000088205(gene)|ensembl:ENST00000263239(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0071392"(cellular response to estradiol stimulus)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RmupZbt33/w1V7Uq5vnRO36j2Tc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25786	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359352|uniprotkb:Q9BRV9|uniprotkb:A8K400|uniprotkb:Q53YE8|ensembl:ENSP00000379676	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa1_human(display_long)|uniprotkb:PSMA1(gene name)|psi-mi:PSMA1(display_short)|uniprotkb:PROS30(gene name synonym)|uniprotkb:PSC2(gene name synonym)|uniprotkb:Proteasome component C2(gene name synonym)|uniprotkb:Macropain subunit C2(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C2(gene name synonym)|uniprotkb:Proteasome nu chain(gene name synonym)|uniprotkb:30 kDa prosomal protein(gene name synonym)|uniprotkb:HC2(gene name synonym)|uniprotkb:NU(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002777.1|refseq:NP_683877.1|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000129084(gene)|ensembl:ENST00000396394(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002376"(immune system process)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035144|mint:P25786|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|dip:DIP-29369N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tAADzZ1G9E/0BBeS8vybNx97v7k9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P56385	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2270000|uniprotkb:Q0D2L9|ensembl:ENSP00000306003	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atp5i_human(display_long)|uniprotkb:ATP5ME(gene name)|psi-mi:ATP5ME(display_short)|uniprotkb:ATP5I(gene name synonym)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:ATP5K(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009031.1|ensembl:ENSG00000169020(gene)|ensembl:ENST00000304312(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P56385|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NYpqzWQYASXwSwU/BYDTMU2tJjI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00839	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62993	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WXE9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-539742|uniprotkb:Q6NT47|uniprotkb:Q96RI7|uniprotkb:Q96RU6|uniprotkb:Q17R24|uniprotkb:G3V2T7|uniprotkb:Q59H11|intact:EBI-28967360	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ston2_human(display_long)|uniprotkb:Stoned B(gene name synonym)|uniprotkb:STON2(gene name)|psi-mi:STON2(display_short)|uniprotkb:STNB(gene name synonym)|uniprotkb:STN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR017110(Stonin)|ensembl:ENST00000555447|ensembl:ENSP00000450857|ensembl:ENSG00000140022|ensembl:ENST00000614646|ensembl:ENSP00000477736|interpro:IPR028565|refseq:NP_149095.2|interpro:IPR012320(Stonin homology)|interpro:IPR022699|interpro:IPR036168|interpro:IPR031228|refseq:NP_001243359.1|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043005"(neuron projection)|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048488"(synaptic vesicle endocytosis)|rcsb pdb:2JXC|mint:Q8WXE9	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AtPNlh4TC/kL9DnGQJqv1BVwQCM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62701	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354303|uniprotkb:P12631|uniprotkb:P12750|uniprotkb:P27576|uniprotkb:Q14727|uniprotkb:P55831|uniprotkb:Q6IPY4|ensembl:ENSP00000362744	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs4x_human(display_long)|uniprotkb:RPS4X(gene name)|psi-mi:RPS4X(display_short)|uniprotkb:CCG2(gene name synonym)|uniprotkb:RPS4(gene name synonym)|uniprotkb:SCAR(gene name synonym)|uniprotkb:Single copy abundant mRNA protein(gene name synonym)|uniprotkb:SCR10(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000998.1|rcsb pdb:6OLI|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000198034(gene)|ensembl:ENST00000316084(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005824(KOW)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR018199|interpro:IPR032277|interpro:IPR036986|interpro:IPR038237|interpro:IPR041982|mint:P62701|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|go:"GO:0045727"(positive regulation of translation)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2ZuLXqBSDkK0CtN3mnIDoFAR8yI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61289	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05141	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02008	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719843|uniprotkb:Q6IBF6|ensembl:ENSP00000252951	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbaz_human(display_long)|uniprotkb:Hemoglobin zeta chain(gene name synonym)|uniprotkb:Zeta-globin(gene name synonym)|uniprotkb:HBAZ(gene name synonym)|uniprotkb:HBZ(gene name)|psi-mi:HBZ(display_short)|uniprotkb:HBZ2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005323.1|ensembl:ENSG00000130656(gene)|ensembl:ENST00000252951(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002340(Haemoglobin, zeta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1JEB|rcsb pdb:3W4U|refseq:XP_005255345.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:K2E42b7eK+PiEY1MPC/IepTjnOI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P00338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05198	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056162|ensembl:ENSP00000256383|ensembl:ENSP00000425299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if2a_human(display_long)|uniprotkb:EIF2S1(gene name)|psi-mi:EIF2S1(display_short)|uniprotkb:EIF2A(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004085.1|ensembl:ENSG00000134001(gene)|ensembl:ENST00000256383(transcript)|ensembl:ENST00000466499(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|mint:P05198|rcsb pdb:1KL9|rcsb pdb:1Q8K|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|dip:DIP-39418N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hG3fLbQuFpe5z8zS/bt/TnpEpzA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-726937|uniprotkb:Q6NZ54|uniprotkb:Q7M4M5|uniprotkb:Q3KQW2|uniprotkb:B2R4H3|uniprotkb:B4E3C2|uniprotkb:B5ME31|uniprotkb:J3QL51|ensembl:ENSP00000462023|ensembl:ENSP00000462385|ensembl:ENSP00000463842|ensembl:ENSP00000480555|ensembl:ENSP00000482577	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl17_human(display_long)|uniprotkb:60S ribosomal protein L23(gene name synonym)|uniprotkb:PD-1(gene name synonym)|uniprotkb:RPL17(gene name)|psi-mi:RPL17(display_short)|uniprotkb:Large ribosomal subunit protein uL22(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000976.1|refseq:NP_001030178.1|refseq:NP_001186269.1|refseq:NP_001186270.1|refseq:NP_001186271.1|refseq:NP_001186272.1|refseq:NP_001186273.1|refseq:NP_001186274.1|ensembl:ENSG00000265681(gene)|ensembl:ENST00000579248(transcript)|ensembl:ENST00000579408(transcript)|ensembl:ENST00000580261(transcript)|ensembl:ENST00000618613(transcript)|ensembl:ENST00000618619(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001063(Ribosomal protein L22/L17)|interpro:IPR005721(Ribosomal protein L22/L17, eukaryotic/archaeal)|interpro:IPR018260|interpro:IPR036394|mint:P18621|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/i0W3WoeFakz+8R/YMYf2JQZytI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NX63	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-743375|ensembl:ENSP00000262570	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99714	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-79964|ensembl:ENSP00000168216|uniprotkb:Q8TCV9|uniprotkb:Q96HD5|uniprotkb:Q5H927|uniprotkb:Q6IBS9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hcd2_human(display_long)|uniprotkb:HSD17B10(gene name)|psi-mi:HSD17B10(display_short)|uniprotkb:SCHAD(gene name synonym)|uniprotkb:XH98G2(gene name synonym)|uniprotkb:HADH2(gene name synonym)|uniprotkb:3-hydroxyacyl-CoA dehydrogenase type II(gene name synonym)|uniprotkb:Type II HADH(gene name synonym)|uniprotkb:3-hydroxy-2-methylbutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:Endoplasmic reticulum-associated amyloid beta-peptide-binding protein(gene name synonym)|uniprotkb:Short-chain type dehydrogenase/reductase XH98G2(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 2(gene name synonym)|uniprotkb:2-methyl-3-hydroxybutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:ERAB(gene name synonym)|uniprotkb:MRPP2(gene name synonym)|uniprotkb:SDR5C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 5C member 1(gene name synonym)|uniprotkb:17-beta-estradiol 17-dehydrogenase(gene name synonym)|uniprotkb:"3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))"(gene name synonym)|uniprotkb:"3alpha(or 20beta)-hydroxysteroid dehydrogenase"(gene name synonym)|uniprotkb:7-alpha-hydroxysteroid dehydrogenase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:2O23|reactome:R-HSA-6785470|reactome:R-HSA-6787450|reactome:R-HSA-70895|reactome:R-HSA-8868766|ensembl:ENSG00000072506(gene)|ensembl:ENST00000168216(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008207"(C21-steroid hormone metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008709"(cholate 7-alpha-dehydrogenase activity)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0047015"(3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity)|go:"GO:0047035"("testosterone dehydrogenase (NAD+) activity")|go:"GO:0047044"(androstan-3-alpha,17-beta-diol dehydrogenase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0062173"(brexanolone metabolic process)|go:"GO:0070901"(mitochondrial tRNA methylation)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|go:"GO:0106281"("chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity")|go:"GO:0106282"("isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:0106283"("ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q99714|rcsb pdb:1F67|rcsb pdb:1SO8|rcsb pdb:1U7T|refseq:NP_001032900.1|refseq:NP_004484.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:q6/pRFyay7gQ6bb2rzvKYgfkeaE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P67870	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07741	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047565|uniprotkb:Q3KP55|uniprotkb:G5E9J2|uniprotkb:Q68DF9|ensembl:ENSP00000367615	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:apt_human(display_long)|uniprotkb:APRT(gene name)|psi-mi:APRT(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000476.1|ensembl:ENSG00000198931(gene)|ensembl:ENST00000378364(transcript)|go:"GO:0002055"(adenine binding)|go:"GO:0003999"(adenine phosphoribosyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006168"(adenine salvage)|go:"GO:0007595"(lactation)|go:"GO:0007625"(grooming behavior)|go:"GO:0016208"(AMP binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0044209"(AMP salvage)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005764(Adenine phosphoribosyl transferase)|interpro:IPR029057|rcsb pdb:1OPU|rcsb pdb:1ORE|rcsb pdb:1ZN7|rcsb pdb:1ZN8|rcsb pdb:1ZN9|rcsb pdb:4X44|rcsb pdb:4X45|rcsb pdb:6FCH|rcsb pdb:6FCI|rcsb pdb:6FCL|rcsb pdb:6FD4|rcsb pdb:6FD5|rcsb pdb:6FD6|rcsb pdb:6HGP|rcsb pdb:6HGQ|rcsb pdb:6HGR|rcsb pdb:6HGS|reactome:R-HSA-6798695|reactome:R-HSA-74217|refseq:NP_001025189.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x046RPUzHysaN5PWMM0UCSyt9xI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P56192	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22681	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06576	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61247	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352378|uniprotkb:P33443|uniprotkb:P49241|uniprotkb:B2R4D4|intact:EBI-3440915|uniprotkb:D3DP05|ensembl:ENSP00000346050	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs3a_human(display_long)|uniprotkb:RPS3A(gene name)|psi-mi:RPS3A(display_short)|uniprotkb:MFTL(gene name synonym)|uniprotkb:FTE1(gene name synonym)|uniprotkb:v-fos transformation effector protein(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000997.1|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:4V6X|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000145425(gene)|ensembl:ENST00000274065(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|mint:P61247|rcsb pdb:4UG0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6OM7|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-29408N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:g1TMzz8OFWEuhrRCoecj7KW0qTQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6P2E9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P32969	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358122|ensembl:ENSP00000346022|ensembl:ENSP00000400467|ensembl:ENSP00000494697	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl9_human(display_long)|uniprotkb:RPL9(gene name)|psi-mi:RPL9(display_short)|uniprotkb:RPL9P7(gene name)|psi-mi:RPL9P7(display_short)|uniprotkb:RPL9P8(gene name)|psi-mi:RPL9P8(display_short)|uniprotkb:RPL9P9(gene name)|psi-mi:RPL9P9(display_short)|uniprotkb:Large ribosomal subunit protein uL6(gene name synonym)|uniprotkb:OK/SW-cl.103(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000652.2|refseq:NP_001020092.1|ensembl:ENSG00000163682(gene)|ensembl:ENST00000295955(transcript)|ensembl:ENST00000449470(transcript)|ensembl:ENST00000645496(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR000702(Ribosomal protein L6)|interpro:IPR002359(Ribosomal protein L6, conserved site-2)|interpro:IPR020040|interpro:IPR036789|mint:P32969|rcsb pdb:2CQL|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:v0thFydYo0aEqBblJoqQX8b7JCA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35637	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46777	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358018|ensembl:ENSP00000359345|uniprotkb:Q53HH6|uniprotkb:Q9H3F4|uniprotkb:Q32LZ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl5_human(display_long)|uniprotkb:RPL5(gene name)|psi-mi:RPL5(display_short)|uniprotkb:Large ribosomal subunit protein uL18(gene name synonym)|uniprotkb:MSTP030(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|ensembl:ENSG00000122406(gene)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|ensembl:ENST00000370321(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|refseq:NP_000960.2|dip:DIP-31152N|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|mint:P46777|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rs+zAc+IPrEqv7DHNcy2GIkQkfY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46782	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350569|uniprotkb:Q96BN0|uniprotkb:B2R4T2|ensembl:ENSP00000196551|ensembl:ENSP00000470114|ensembl:ENSP00000472985	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs5_human(display_long)|uniprotkb:RPS5(gene name)|psi-mi:RPS5(display_short)|uniprotkb:Small ribosomal subunit protein uS7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001000.2|rcsb pdb:6OLZ|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Z6M|rcsb pdb:6XA1|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6Y0G|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:5FLX|rcsb pdb:6OLG|rcsb pdb:6OLI|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|ensembl:ENSG00000083845(gene)|ensembl:ENST00000196551(transcript)|ensembl:ENST00000596046(transcript)|ensembl:ENST00000601521(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823|mint:P46782|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:5AJ0|reactome:R-HSA-72702	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SoCJdf2InngZZtlz5qD1k5CEfEo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16181	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2009373|uniprotkb:Q52M76|uniprotkb:Q6NX50|ensembl:ENSP00000381992	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sept7_human(display_long)|uniprotkb:SEPTIN7(gene name)|psi-mi:SEPTIN7(display_short)|uniprotkb:CDC10(gene name synonym)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:SEPT7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001779.3|dip:DIP-47093N|ensembl:ENSG00000122545(gene)|ensembl:ENST00000399034(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR008115(Septin 7)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:2QAG|rcsb pdb:3T5D|rcsb pdb:3TW4|rcsb pdb:6N0B|rcsb pdb:6N12|rcsb pdb:6UQQ|reactome:R-HSA-5687128	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CweIjGLXC7eubvKR7vkkihEkcHg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13151	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724092|ensembl:ENSP00000316042|intact:EBI-1043661|uniprotkb:Q6IB18	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa0_human(display_long)|uniprotkb:HNRPA0(gene name synonym)|uniprotkb:HNRNPA0(gene name)|psi-mi:HNRNPA0(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006796.1|ensembl:ENSG00000177733(gene)|ensembl:ENST00000314940(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034801|interpro:IPR035979|mint:Q13151|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:buyQxR8FLxd4N6jRhwVsroeGrBw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92841	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-746012|uniprotkb:Q69YT1|uniprotkb:Q6ICD6|uniprotkb:H3BLZ8|uniprotkb:B1AHM0|ensembl:ENSP00000385536	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx17_human(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:RNA-dependent helicase p72(gene name synonym)|uniprotkb:DEAD box protein p72(gene name synonym)|uniprotkb:DDX17(gene name)|psi-mi:DDX17(display_short)|uniprotkb:DEAD box protein p82(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006377.2|ensembl:ENSG00000100201(gene)|ensembl:ENST00000403230(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q92841|rcsb pdb:6UV0|rcsb pdb:6UV1|rcsb pdb:6UV2|rcsb pdb:6UV3|rcsb pdb:6UV4|reactome:R-HSA-3899300|dip:DIP-29843N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3UhUuhRSZg/zlM7UPDKYCqNmUho9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06493	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26373	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356849|uniprotkb:Q3KQT8|uniprotkb:Q9BPX0|uniprotkb:Q567Q8|uniprotkb:B4DLX3|uniprotkb:F5H1S2|ensembl:ENSP00000307889|ensembl:ENSP00000376811|ensembl:ENSP00000455009	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl13_human(display_long)|uniprotkb:RPL13(gene name)|psi-mi:RPL13(display_short)|uniprotkb:BBC1(gene name synonym)|uniprotkb:Breast basic conserved protein 1(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL13(gene name synonym)|uniprotkb:OK/SW-cl.46(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000968.2|refseq:NP_150254.1|refseq:NP_001230059.1|refseq:NP_001230060.1|ensembl:ENSG00000167526(gene)|ensembl:ENST00000311528(transcript)|ensembl:ENST00000393099(transcript)|ensembl:ENST00000567815(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0060348"(bone development)|interpro:IPR001380(Ribosomal protein L13e)|interpro:IPR018256|mint:P26373|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-192823	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2SZ+AEe41Ystwj9t9I0Z1cZ5GQ49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48729	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1383726|uniprotkb:Q96HD2|uniprotkb:Q5U046|uniprotkb:Q5U047|uniprotkb:Q6FGA2|uniprotkb:Q4JJA0|uniprotkb:Q9UDK3|intact:EBI-11048253|uniprotkb:D3DQG0|uniprotkb:D3DQG1|uniprotkb:Q71TU5|ensembl:ENSP00000367074	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kc1a_human(display_long)|uniprotkb:CSNK1A1(gene name)|psi-mi:CSNK1A1(display_short)|uniprotkb:CK1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001020276.1|refseq:NP_001883.4|refseq:NP_001258670.1|refseq:NP_001258671.1|dip:DIP-40367N|ensembl:ENSG00000113712(gene)|ensembl:ENST00000377843(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904424"(regulation of GTP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48729|rcsb pdb:5FQD|rcsb pdb:6GZD|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5635838	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2rG1/sMVnsRKUEWsLhLAyHvqPnY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42704	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95372	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715999|uniprotkb:Q7Z4Z2|ensembl:ENSP00000363638	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lypa2_human(display_long)|uniprotkb:Lysophospholipase II(gene name synonym)|uniprotkb:LYPLA2(gene name)|psi-mi:LYPLA2(display_short)|uniprotkb:APT2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009191.1|ensembl:ENSG00000011009(gene)|ensembl:ENST00000374514(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007411"(axon guidance)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0045296"(cadherin binding)|go:"GO:0046464"(acylglycerol catabolic process)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905344"(prostaglandin catabolic process)|interpro:IPR003140(Phospholipase/carboxylesterase)|interpro:IPR029058|rcsb pdb:5SYN|rcsb pdb:6BJE|reactome:R-HSA-373760	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yJ0IGnOIc6UvuzuLdZb8WzlN9aY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15691	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1004115|uniprotkb:Q3KQS8|uniprotkb:B2R6I7|uniprotkb:E1P5M8|ensembl:ENSP00000364721	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mare1_human(display_long)|uniprotkb:APC-binding protein EB1(gene name synonym)|uniprotkb:End-binding protein 1(gene name synonym)|uniprotkb:MAPRE1(gene name)|psi-mi:MAPRE1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036457.1|refseq:XP_011526998.1|ensembl:ENSG00000101367(gene)|ensembl:ENST00000375571(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0016477"(cell migration)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:1903033"(positive regulation of microtubule plus-end binding)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:1904825"(protein localization to microtubule plus-end)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1905721"(mitotic spindle astral microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR004953(EB1, C-terminal)|interpro:IPR027328|interpro:IPR027739|interpro:IPR036133|interpro:IPR036872|mint:Q15691|rcsb pdb:1PA7|rcsb pdb:1TXQ|rcsb pdb:1UEG|rcsb pdb:1VKA|rcsb pdb:1WU9|rcsb pdb:1YIB|rcsb pdb:1YIG|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2QJZ|rcsb pdb:2R8U|rcsb pdb:3GJO|rcsb pdb:3MTU|rcsb pdb:3MUD|rcsb pdb:3TQ7|rcsb pdb:4XA1|rcsb pdb:4XA3|rcsb pdb:4XA6|rcsb pdb:5JV3|rcsb pdb:5JVM|rcsb pdb:5JVP|rcsb pdb:5JVR|rcsb pdb:5JVS|rcsb pdb:5JVU|rcsb pdb:5JX1|rcsb pdb:5WLQ|rcsb pdb:6PF2|rcsb pdb:6PFP|rcsb pdb:6YF5|rcsb pdb:6YSH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|dip:DIP-38018N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+JBCBM7dbbrxn6mX8RiwejYWJ2U9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14152	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00571	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13247	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745230|uniprotkb:Q13244|uniprotkb:Q13245|uniprotkb:Q96J06|uniprotkb:Q9UJB8|uniprotkb:Q9Y3N7|uniprotkb:B7Z6J3|uniprotkb:E1P5W6|ensembl:ENSP00000244020	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:srsf6_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP55(gene name synonym)|uniprotkb:SRSF6(gene name)|psi-mi:SRSF6(display_short)|uniprotkb:SRP55(gene name synonym)|uniprotkb:SFRS6(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006266.2|ensembl:ENSG00000124193(gene)|ensembl:ENST00000244020(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0032868"(response to insulin)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0045617"(negative regulation of keratinocyte differentiation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061041"(regulation of wound healing)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029541|interpro:IPR034511|interpro:IPR035979|mint:Q13247|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vU4nobP3g/hsgnll0mQgjJcME2k9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99848	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048111|uniprotkb:Q96A66|ensembl:ENSP00000236051	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ebp2_human(display_long)|uniprotkb:EBNA1-binding protein 2(gene name synonym)|uniprotkb:Nucleolar protein p40(gene name synonym)|uniprotkb:EBNA1BP2(gene name)|psi-mi:EBNA1BP2(display_short)|uniprotkb:EBP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153408.1|refseq:NP_006815.2|ensembl:ENSG00000117395(gene)|ensembl:ENST00000236051(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR008610(Eukaryotic rRNA processing)|mint:Q99848|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lUFbxBko/pJHiNq8uuefmK3Xqp89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14868	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358730|uniprotkb:Q2TNI3|uniprotkb:Q32Q69|uniprotkb:Q53HV4|uniprotkb:Q53YC5|uniprotkb:Q9BW52|uniprotkb:Q68CR9|uniprotkb:A8K3J2|uniprotkb:D3DP77|ensembl:ENSP00000264161	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sydc_human(display_long)|uniprotkb:DARS1(gene name)|psi-mi:DARS1(display_short)|uniprotkb:Aspartyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 40 protein(gene name synonym)|uniprotkb:DARS(gene name synonym)|uniprotkb:PIG40(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001340.2|refseq:NP_001280241.1|ensembl:ENSG00000115866(gene)|ensembl:ENST00000264161(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006422"(aspartyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0045202"(synapse)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004523(Aspartyl-tRNA synthetase, class IIb, archea/euk type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:P14868|rcsb pdb:4J15|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Yzpil/THkSHGR/ixVyQbV3RZz/E9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62424	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354172|uniprotkb:P11518|uniprotkb:Q5T8U4|ensembl:ENSP00000361076|ensembl:ENSP00000487443	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl7a_human(display_long)|uniprotkb:RPL7A(gene name)|psi-mi:RPL7A(display_short)|uniprotkb:SURF-3(gene name synonym)|uniprotkb:SURF3(gene name synonym)|uniprotkb:Surfeit locus protein 3(gene name synonym)|uniprotkb:PLA-X polypeptide(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000963.1|dip:DIP-31502N|ensembl:ENSG00000148303(gene)|ensembl:ENSG00000280858(gene)|ensembl:ENST00000323345(transcript)|ensembl:ENST00000630979(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR001921(Ribosomal protein L7A)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P62424|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|go:"GO:0005634"(nucleus)|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:shPtLmc+oabT/rSwho+tP1iJy4k9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62258	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75608	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052185|uniprotkb:O43202|uniprotkb:Q9UQF9|ensembl:ENSP00000320043	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lypa1_human(display_long)|uniprotkb:Lysophospholipase 1(gene name synonym)|uniprotkb:Lysophospholipase I(gene name synonym)|uniprotkb:LYPLA1(gene name)|psi-mi:LYPLA1(display_short)|uniprotkb:APT1(gene name synonym)|uniprotkb:LPL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006321.1|refseq:NP_001266285.1|refseq:NP_001266286.1|refseq:NP_001266287.1|refseq:NP_001266288.1|refseq:NP_001266289.1|ensembl:ENSG00000120992(gene)|ensembl:ENST00000316963(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0016298"(lipase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003140(Phospholipase/carboxylesterase)|interpro:IPR029058|rcsb pdb:1FJ2|rcsb pdb:5SYM|rcsb pdb:6QGN|go:"GO:0005737"(cytoplasm)|rcsb pdb:6QGO|rcsb pdb:6QGQ|rcsb pdb:6QGS|reactome:R-HSA-203615|reactome:R-HSA-9648002	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y/NsD5HcH2FjnwUrSCBzeevQU+s9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52272	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9HAV4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00299	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347404|uniprotkb:Q15089|uniprotkb:Q502X1|ensembl:ENSP00000404037|ensembl:ENSP00000404589|ensembl:ENSP00000406088|ensembl:ENSP00000406335|ensembl:ENSP00000406968|ensembl:ENSP00000407429|ensembl:ENSP00000407791|ensembl:ENSP00000408094|ensembl:ENSP00000408357|ensembl:ENSP00000409247|ensembl:ENSP00000409979|ensembl:ENSP00000410965|ensembl:ENSP00000412217|ensembl:ENSP00000413330|ensembl:ENSP00000416211|ensembl:ENSP00000477623|ensembl:ENSP00000478930|ensembl:ENSP00000479501|ensembl:ENSP00000479808|ensembl:ENSP00000480256|ensembl:ENSP00000482255|ensembl:ENSP00000484581|ensembl:ENSP00000364934|ensembl:ENSP00000364935|ensembl:ENSP00000364940|ensembl:ENSP00000372896|ensembl:ENSP00000372897|ensembl:ENSP00000379229|ensembl:ENSP00000382926|ensembl:ENSP00000382931|ensembl:ENSP00000391395|ensembl:ENSP00000398056|ensembl:ENSP00000400280|ensembl:ENSP00000400532|ensembl:ENSP00000401292	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:clic1_human(display_long)|uniprotkb:CLIC1(gene name)|psi-mi:CLIC1(display_short)|uniprotkb:NCC27(gene name synonym)|uniprotkb:Nuclear chloride ion channel 27(gene name synonym)|uniprotkb:Chloride channel ABP(gene name synonym)|uniprotkb:Regulatory nuclear chloride ion channel protein(gene name synonym)|uniprotkb:G6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001279.2|refseq:NP_001274522.1|refseq:NP_001274523.1|ensembl:ENST00000375779(transcript)|ensembl:ENST00000375780(transcript)|ensembl:ENST00000375784(transcript)|ensembl:ENST00000383404(transcript)|ensembl:ENST00000383405(transcript)|ensembl:ENST00000395892(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006821"(chloride transport)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030259|go:"GO:0005634"(nucleus)|ensembl:ENSG00000206394(gene)|ensembl:ENSG00000213719(gene)|ensembl:ENSG00000223639(gene)|ensembl:ENSG00000226248(gene)|ensembl:ENSG00000226417(gene)|ensembl:ENSG00000226651(gene)|ensembl:ENSG00000230685(gene)|ensembl:ENST00000400052(transcript)|ensembl:ENST00000400058(transcript)|ensembl:ENST00000415179(transcript)|ensembl:ENST00000418285(transcript)|ensembl:ENST00000420458(transcript)|ensembl:ENST00000422167(transcript)|ensembl:ENST00000423055(transcript)|ensembl:ENST00000423143(transcript)|ensembl:ENST00000423804(transcript)|ensembl:ENST00000425464(transcript)|ensembl:ENST00000431921(transcript)|ensembl:ENST00000433916(transcript)|ensembl:ENST00000434202(transcript)|ensembl:ENST00000435242(transcript)|ensembl:ENST00000438708(transcript)|ensembl:ENST00000438750(transcript)|ensembl:ENST00000442045(transcript)|ensembl:ENST00000447338(transcript)|ensembl:ENST00000447369(transcript)|ensembl:ENST00000451546(transcript)|ensembl:ENST00000456863(transcript)|ensembl:ENST00000457485(transcript)|ensembl:ENST00000614673(transcript)|ensembl:ENST00000614982(transcript)|ensembl:ENST00000616760(transcript)|ensembl:ENST00000618288(transcript)|ensembl:ENST00000619727(transcript)|ensembl:ENST00000621055(transcript)|ensembl:ENST00000622613(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005615"(extracellular space)|interpro:IPR036282|interpro:IPR040079|mint:O00299|interpro:IPR036249|rcsb pdb:1K0M|rcsb pdb:1K0N|rcsb pdb:1K0O|rcsb pdb:1RK4|rcsb pdb:3O3T|rcsb pdb:3P8W|rcsb pdb:3P90|rcsb pdb:3QR6|rcsb pdb:3SWL|rcsb pdb:3TGZ|rcsb pdb:3UVH|rcsb pdb:4IQA|rcsb pdb:4JZQ|rcsb pdb:4K0G|rcsb pdb:4K0N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HVux62IcNdqcPgqmlGlIyZTLpFo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11387	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876302|ensembl:ENSP00000354522|uniprotkb:Q15610|uniprotkb:Q5TFY3|uniprotkb:Q9UJN0|uniprotkb:O43256|uniprotkb:Q12855|uniprotkb:Q12856|uniprotkb:A8KA78|uniprotkb:E1P5W3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:top1_human(display_long)|uniprotkb:DNA topoisomerase I(gene name synonym)|uniprotkb:TOP1(gene name)|psi-mi:TOP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198900(gene)|ensembl:ENST00000361337(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0012501"(programmed cell death)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|refseq:NP_003277.1|dip:DIP-36356N|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202|mint:P11387|rcsb pdb:1A31|rcsb pdb:1A35|rcsb pdb:1A36|rcsb pdb:1EJ9|rcsb pdb:1K4S|rcsb pdb:1K4T|rcsb pdb:1LPQ|rcsb pdb:1NH3|rcsb pdb:1R49|rcsb pdb:1RR8|rcsb pdb:1RRJ|rcsb pdb:1SC7|rcsb pdb:1SEU|rcsb pdb:1T8I|rcsb pdb:1TL8|reactome:R-HSA-4615885	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kB+3PVybgNp2mtOmDa7x8sygFuU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PAU2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189929|ensembl:ENSP00000482486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pau2_human(display_long)|uniprotkb:RAVER1(gene name)|psi-mi:RAVER1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000611074(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034633|interpro:IPR034635|interpro:IPR035979|ensembl:ENSG00000161847(gene)|refseq:NP_597709.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:R49B14TFxiQLK5QlLBcHyZQTKD09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P01857	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13838	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348622|uniprotkb:B0S8C0|uniprotkb:Q5STB8|uniprotkb:O43496|uniprotkb:Q0EFA1|uniprotkb:Q2L6F9|uniprotkb:Q53GL9|uniprotkb:Q5RJ64|uniprotkb:Q5RJ66|uniprotkb:Q5ST94|uniprotkb:Q5STB4|uniprotkb:Q5STB5|uniprotkb:Q5STB7|uniprotkb:Q5STU4|uniprotkb:Q5STU5|uniprotkb:Q5STU6|uniprotkb:Q5STU8|uniprotkb:Q71V76|ensembl:ENSP00000373000|ensembl:ENSP00000379475|ensembl:ENSP00000383151|ensembl:ENSP00000383152|ensembl:ENSP00000387994|ensembl:ENSP00000388880|ensembl:ENSP00000390999|ensembl:ENSP00000391463|ensembl:ENSP00000393712|ensembl:ENSP00000394160|ensembl:ENSP00000398775|ensembl:ENSP00000399030|ensembl:ENSP00000400326|ensembl:ENSP00000404695|ensembl:ENSP00000405560|ensembl:ENSP00000407419|ensembl:ENSP00000411136|ensembl:ENSP00000411853|ensembl:ENSP00000416269	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dx39b_human(display_long)|uniprotkb:UAP56(gene name synonym)|uniprotkb:DDX39B(gene name)|psi-mi:DDX39B(display_short)|uniprotkb:DEAD box protein UAP56(gene name synonym)|uniprotkb:56 kDa U2AF65-associated protein(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p47(gene name synonym)|uniprotkb:HLA-B-associated transcript 1 protein(gene name synonym)|uniprotkb:BAT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004631.1|refseq:NP_542165.1|ensembl:ENSG00000198563(gene)|ensembl:ENSG00000215425(gene)|ensembl:ENSG00000225073(gene)|ensembl:ENSG00000225859(gene)|ensembl:ENSG00000229496(gene)|ensembl:ENSG00000230624(gene)|ensembl:ENSG00000235439(gene)|ensembl:ENST00000383508(transcript)|ensembl:ENST00000396172(transcript)|ensembl:ENST00000400295(transcript)|ensembl:ENST00000400296(transcript)|ensembl:ENST00000412106(transcript)|ensembl:ENST00000412330(transcript)|ensembl:ENST00000413678(transcript)|ensembl:ENST00000414440(transcript)|ensembl:ENST00000415689(transcript)|ensembl:ENST00000416863(transcript)|ensembl:ENST00000430784(transcript)|ensembl:ENST00000431360(transcript)|ensembl:ENST00000441425(transcript)|ensembl:ENST00000445218(transcript)|ensembl:ENST00000448296(transcript)|ensembl:ENST00000453138(transcript)|ensembl:ENST00000456476(transcript)|ensembl:ENST00000456666(transcript)|ensembl:ENST00000458640(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000346"(transcription export complex)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0008380"(RNA splicing)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q13838|rcsb pdb:1T5I|rcsb pdb:1T6N|rcsb pdb:1XTI|rcsb pdb:1XTJ|rcsb pdb:1XTK|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9013418	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Cl/rf1oq31fZbLHC2foUXu9MBOE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43143	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237044|uniprotkb:Q9NQT7|ensembl:ENSP00000336741	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx15_human(display_long)|uniprotkb:DHX15(gene name)|psi-mi:DHX15(display_short)|uniprotkb:DBP1(gene name synonym)|uniprotkb:DDX15(gene name synonym)|uniprotkb:DEAH box protein 15(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001349.2|dip:DIP-38211N|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR044756|mint:O43143|rcsb pdb:5XDR|rcsb pdb:6ID1|rcsb pdb:6SH6|rcsb pdb:6SH7|reactome:R-HSA-72163|ensembl:ENSG00000109606(gene)|ensembl:ENST00000336812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0043279"(response to alkaloid)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rOkQ5RG/3gc1/0Qcn5ANS6ImepY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07900-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190772|ensembl:ENSP00000335153	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p07900-2(display_long)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym)|uniprotkb:HSP90AA1-2(isoform synonym)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000080824(gene)|ensembl:ENST00000334701(transcript)|intact:EBI-296047(isoform-parent)|uniprotkb:P07900-2(isoform-parent)	-	-	isoform-comment:"Variant in position: 71:M->L (in dbSNP:rs8005905)."	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zSFsoTnWMCxMgg5CMgkY21uBpb89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P41252	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355303|uniprotkb:Q5TCD0|uniprotkb:Q9H588|uniprotkb:A8KAE9|uniprotkb:Q7Z3T4|ensembl:ENSP00000364794|ensembl:ENSP00000406448|ensembl:ENSP00000507144	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syic_human(display_long)|uniprotkb:IARS1(gene name)|psi-mi:IARS1(display_short)|uniprotkb:IARS(gene name synonym)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002152.2|refseq:NP_038203.2|ensembl:ENSG00000196305(gene)|ensembl:ENST00000375643(transcript)|ensembl:ENST00000443024(transcript)|ensembl:ENST00000683565(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023586|interpro:IPR033709|mint:P41252|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:maAJX/O1Ryxr5NVFQEWvXNgHXyY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NVI7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:IZKJEVLLS/DFINgBgO5frizN1P49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96CW1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62195	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N	-	-	crc64:29C6410C4A85A7F7	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51570	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2269932|uniprotkb:B2RC07|intact:EBI-6190170|uniprotkb:B4E1G6|ensembl:ENSP00000225614|ensembl:ENSP00000465930	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:galk1_human(display_long)|uniprotkb:GALK1(gene name)|psi-mi:GALK1(display_short)|uniprotkb:GALK(gene name synonym)|uniprotkb:Galactose kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0019388"(galactose catabolic process)|go:"GO:0019402"(galactitol metabolic process)|go:"GO:0061623"(glycolytic process from galactose)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000705(Galactokinase)|interpro:IPR006203(GHMP kinase, ATP-binding, conserved site)|interpro:IPR006204(GHMP kinase)|interpro:IPR006206(Mevalonate and galactokinase)|interpro:IPR013750(GHMP kinase, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR019539|interpro:IPR019741|interpro:IPR020568|interpro:IPR036554|mint:P51570|ensembl:ENSG00000108479(gene)|ensembl:ENST00000225614(transcript)|ensembl:ENST00000588479(transcript)|go:"GO:0004335"(galactokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005534"(galactose binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0016020"(membrane)|rcsb pdb:1WUU|rcsb pdb:1YH7|rcsb pdb:6GR2|rcsb pdb:6Q3W|rcsb pdb:6Q3X|rcsb pdb:6Q8Z|rcsb pdb:6Q90|rcsb pdb:6Q91|rcsb pdb:6QJE|rcsb pdb:6ZFH|rcsb pdb:6ZGV|rcsb pdb:6ZGW|rcsb pdb:6ZGX|rcsb pdb:6ZGY|rcsb pdb:6ZGZ|reactome:R-HSA-5609976|reactome:R-HSA-70370	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TtFcTQq+nspsst+xInA/huo/ZbU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35268	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354533|intact:EBI-1055963|uniprotkb:Q6IBD1|uniprotkb:B2R495|ensembl:ENSP00000346088	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl22_human(display_long)|uniprotkb:RPL22(gene name)|psi-mi:RPL22(display_short)|uniprotkb:Heparin-binding protein HBp15(gene name synonym)|uniprotkb:Epstein-Barr virus small RNA-associated protein(gene name synonym)|uniprotkb:EBER-associated protein(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL22(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000974.1|ensembl:ENSG00000116251(gene)|ensembl:ENST00000234875(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008201"(heparin binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045182"(translation regulator activity)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002671(Ribosomal protein L22e)|interpro:IPR038526|mint:P35268|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|reactome:R-HSA-72706|rcsb pdb:6Z6L|rcsb pdb:6Z6M|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0TVillnqDkHmdTwxIedAJCVAdzY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14979	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299727|ensembl:ENSP00000295470|ensembl:ENSP00000422040|ensembl:ENSP00000483254|uniprotkb:Q6SPF2|uniprotkb:Q7KZ74|uniprotkb:Q7KZ75|uniprotkb:Q96IM0|uniprotkb:Q96S43	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrdl_human(display_long)|uniprotkb:HNRNPDL(gene name)|psi-mi:HNRNPDL(display_short)|uniprotkb:AU-rich element RNA-binding factor(gene name synonym)|uniprotkb:HNRPDL(gene name synonym)|uniprotkb:JKT41-binding protein(gene name synonym)|uniprotkb:JKTBP(gene name synonym)|uniprotkb:Protein laAUF1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000152795(gene)|ensembl:ENST00000295470(transcript)|ensembl:ENST00000502762(transcript)|ensembl:ENST00000621267(transcript)|go:"GO:0003677"(DNA binding)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034847|interpro:IPR035979|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|mint:O14979|go:"GO:0003723"(RNA binding)|reactome:R-HSA-8950505|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034046"("poly(G) binding")|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001193929.1|refseq:NP_112740.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oOnEEar8AtKO5G6ldehucaRr4kM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27105	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P00491	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712238|ensembl:ENSP00000354532|uniprotkb:Q15160|uniprotkb:Q5PZ03|uniprotkb:B2R8S5|uniprotkb:D3DS00	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pnph_human(display_long)|uniprotkb:Inosine phosphorylase(gene name synonym)|uniprotkb:PNP(gene name)|psi-mi:PNP(display_short)|uniprotkb:NP(gene name synonym)|uniprotkb:Inosine-guanosine phosphorylase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001882"(nucleoside binding)|go:"GO:0002060"(purine nucleobase binding)|go:"GO:0004731"(purine-nucleoside phosphorylase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006148"(inosine catabolic process)|go:"GO:0006149"(deoxyinosine catabolic process)|go:"GO:0006157"(deoxyadenosine catabolic process)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006204"(IMP catabolic process)|go:"GO:0006738"(nicotinamide riboside catabolic process)|go:"GO:0006955"(immune response)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0019428"(allantoin biosynthetic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043101"(purine-containing compound salvage)|go:"GO:0046059"(dAMP catabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0047975"(guanosine phosphorylase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000845(Nucleoside phosphorylase)|interpro:IPR011268(Inosine guanosine and xanthosine phosphorylase)|interpro:IPR011270(Purine nucleoside phosphorylase I, inosine and guanosine-specific)|interpro:IPR018099|interpro:IPR035994|mint:P00491|rcsb pdb:1M73|rcsb pdb:1PF7|rcsb pdb:1PWY|rcsb pdb:1RCT|rcsb pdb:1RFG|rcsb pdb:1RR6|rcsb pdb:1RSZ|rcsb pdb:1RT9|rcsb pdb:1ULA|rcsb pdb:1ULB|rcsb pdb:1V2H|rcsb pdb:1V3Q|rcsb pdb:1V41|rcsb pdb:1V45|rcsb pdb:1YRY|rcsb pdb:2A0W|rcsb pdb:2A0X|rcsb pdb:2A0Y|rcsb pdb:2OC4|rcsb pdb:2OC9|rcsb pdb:2ON6|rcsb pdb:2Q7O|rcsb pdb:3BGS|rcsb pdb:3D1V|rcsb pdb:3GB9|rcsb pdb:3GGS|ensembl:ENSG00000198805(gene)|ensembl:ENST00000361505(transcript)|go:"GO:0000255"(allantoin metabolic process)|rcsb pdb:3K8O|rcsb pdb:3K8Q|rcsb pdb:3PHB|rcsb pdb:4EAR|rcsb pdb:3INY|rcsb pdb:4EB8|rcsb pdb:4ECE|rcsb pdb:4GKA|rcsb pdb:5ETJ|rcsb pdb:5UGF|reactome:R-HSA-6798695|reactome:R-HSA-74217|reactome:R-HSA-74259|refseq:NP_000261.2|dip:DIP-50406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FOpaxV/M6HIA+THugPZDfN1ej1o9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-443446|ensembl:ENSP00000341885|uniprotkb:Q3MIB1|uniprotkb:B2R5G0|uniprotkb:D3DU82	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs2_human(display_long)|uniprotkb:RPS2(gene name)|psi-mi:RPS2(display_short)|uniprotkb:RPS4(gene name synonym)|uniprotkb:40S ribosomal protein S4(gene name synonym)|uniprotkb:Protein LLRep3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|rcsb pdb:6OLG|rcsb pdb:6OLI|interpro:IPR018192|rcsb pdb:6OLZ|interpro:IPR020568|mint:P15880|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6EK0|rcsb pdb:6G18|rcsb pdb:6XA1|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6G5H|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7JQB|rcsb pdb:7JQC|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-3214858|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8876725|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:7A09|ensembl:ENSG00000140988(gene)|ensembl:ENST00000343262(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045296"(cadherin binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000851(Ribosomal protein S5)|interpro:IPR005324(Ribosomal protein S5, C-terminal)|interpro:IPR005711(Ribosomal protein S5, eukaryotic/archaeal)|interpro:IPR013810(Ribosomal protein S5, N-terminal)|refseq:NP_002943.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JUr2Y3cGk00S8KaTVPymshfaHhc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62753	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356625|uniprotkb:P08227|uniprotkb:P10660|uniprotkb:Q4VBY7|uniprotkb:Q8N6Z7|ensembl:ENSP00000369757	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs6_human(display_long)|uniprotkb:RPS6(gene name)|psi-mi:RPS6(display_short)|uniprotkb:Phosphoprotein NP33(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS6(gene name synonym)|uniprotkb:OK/SW-cl.2(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001001.2|reactome:R-HSA-166208|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR014401(Ribosomal protein S6, eukaryotic)|interpro:IPR018282|mint:P62753|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6F4P|rcsb pdb:6F4Q|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|ensembl:ENSG00000137154(gene)|ensembl:ENST00000380394(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001890"(placenta development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022605"(mammalian oogenesis stage)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0031929"(TOR signaling)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048821"(erythrocyte development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001377(Ribosomal protein S6e)|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|dip:DIP-31507N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:beDuXCIqL99V9JlVfpzx7MdpH689606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61978	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-304185|intact:EBI-28971491|ensembl:ENSP00000317788|ensembl:ENSP00000353552|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q59F98|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62|uniprotkb:Q5T6W4|intact:EBI-3440248|uniprotkb:Q6IBN1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpk_human(display_long)|uniprotkb:HNRNPK(gene name)|psi-mi:HNRNPK(display_short)|uniprotkb:HNRPK(gene name synonym)|uniprotkb:Transformation up-regulated nuclear protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000165119(gene)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000351839(transcript)|ensembl:ENST00000360384(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0002102"(podosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006396"(RNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61978|rcsb pdb:1J5K|rcsb pdb:1KHM|rcsb pdb:1ZZI|rcsb pdb:1ZZJ|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9610379|rcsb pdb:1ZZK|refseq:NP_002131.2|refseq:NP_112552.1|refseq:NP_112553.1|ensembl:ENSP00000317788|ensembl:ENSP00000353552|ensembl:ENST00000376263|ensembl:ENSP00000365439|ensembl:ENST00000376281|ensembl:ENSP00000365458|refseq:NP_001305115.1|refseq:NP_001305116.1|refseq:NP_001305117.1|refseq:XP_016870157.1|refseq:XP_005252017.1|refseq:XP_005252020.1|refseq:XP_005252022.1|dip:DIP-31805N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42356	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-723050|uniprotkb:Q7Z625|uniprotkb:Q9UPG2|ensembl:ENSP00000255882|intact:EBI-11053324	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pi4ka_human(display_long)|uniprotkb:PIK4CA(gene name synonym)|uniprotkb:PI4KA(gene name)|psi-mi:PI4KA(display_short)|uniprotkb:PIK4(gene name synonym)|uniprotkb:Phosphatidylinositol 4-Kinase III alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000241973(gene)|ensembl:ENST00000255882(transcript)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR042236|rcsb pdb:6BQ1|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016301"(kinase activity)|refseq:NP_477352.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tm7wwZPJEvFMfK9xHMPLW9oYtzk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38646	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13057	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745967|uniprotkb:Q6GS23|uniprotkb:Q8NBM7|uniprotkb:Q8NEW1|uniprotkb:Q8WXD4|uniprotkb:Q9NRM3|uniprotkb:B2RA78|uniprotkb:B4DLU0|ensembl:ENSP00000377406|ensembl:ENSP00000393564	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:coasy_human(display_long)|uniprotkb:NBP(gene name synonym)|uniprotkb:POV-2(gene name synonym)|uniprotkb:COASY(gene name)|psi-mi:COASY(display_short)|uniprotkb:PSEC0106(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035994.1|refseq:NP_001035997.2|refseq:NP_079509.5|refseq:XP_011523602.1|ensembl:ENSG00000068120(gene)|ensembl:ENST00000393818(transcript)|ensembl:ENST00000421097(transcript)|go:"GO:0004140"(dephospho-CoA kinase activity)|go:"GO:0004595"(pantetheine-phosphate adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001977(Dephospho-CoA kinase)|interpro:IPR004821(Cytidyltransferase-related)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR027417|reactome:R-HSA-196783|refseq:XP_006722179.1|refseq:XP_016880657.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yMK1IODpj01+JZsNsayJCgEHpyo9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02649	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62333	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357669|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q6IBU3|uniprotkb:B2R975|ensembl:ENSP00000401802	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prs10_human(display_long)|uniprotkb:PSMC6(gene name)|psi-mi:PSMC6(display_short)|uniprotkb:SUG2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002797.3|ensembl:ENST00000445930(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000100519(gene)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62333|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-75815|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-174184|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|dip:DIP-38150N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QE8jzSEp1bpzhOi/oAAnV18QK249606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08779	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356410|uniprotkb:P30654|uniprotkb:Q16402|uniprotkb:Q9UBG8|uniprotkb:A8K488|ensembl:ENSP00000301653	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c16_human(display_long)|uniprotkb:KRT16(gene name)|psi-mi:KRT16(display_short)|uniprotkb:KRT16A(gene name synonym)|uniprotkb:Keratin-16(gene name synonym)|uniprotkb:Cytokeratin-16(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005548.2|ensembl:ENSG00000186832(gene)|ensembl:ENST00000301653(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007568"(aging)|go:"GO:0030216"(keratinocyte differentiation)|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031424"(keratinization)|go:"GO:0042633"(hair cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051546"(keratinocyte migration)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P08779	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NkPTLkWquNNlGYbrXaRkyRmKvmM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9HB71	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q86XP3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722353|uniprotkb:A6NML1|uniprotkb:O75619|uniprotkb:Q68G51|uniprotkb:Q96BK1|uniprotkb:Q96HR7|uniprotkb:Q9Y3V8|uniprotkb:A8KA43|intact:EBI-2555393|ensembl:ENSP00000374574|ensembl:ENSP00000463561|ensembl:ENSP00000464050	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx42_human(display_long)|uniprotkb:DEAD box protein 42(gene name synonym)|uniprotkb:Splicing factor 3B-associated 125 kDa protein(gene name synonym)|uniprotkb:RNA helicase-related protein(gene name synonym)|uniprotkb:RNA helicase-like protein(gene name synonym)|uniprotkb:SF3b DEAD box protein(gene name synonym)|uniprotkb:DDX42(gene name)|psi-mi:DDX42(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_031398.2|refseq:NP_987095.1|refseq:XP_006721720.1|refseq:XP_016879600.1|ensembl:ENSG00000198231(gene)|ensembl:ENST00000389924(transcript)|ensembl:ENST00000578681(transcript)|ensembl:ENST00000583590(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q86XP3|reactome:R-HSA-72163|reactome:R-HSA-72165	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3vZn92rr6cO8qSZJdyq1fguSc489606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24666	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-717701|uniprotkb:P24667|uniprotkb:Q16035|uniprotkb:Q53RU0|uniprotkb:Q16036|uniprotkb:Q16725|uniprotkb:Q3KQX8|uniprotkb:A8K1L9|uniprotkb:B5MCC7|ensembl:ENSP00000272065	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppac_human(display_long)|uniprotkb:Low molecular weight cytosolic acid phosphatase(gene name synonym)|uniprotkb:Red cell acid phosphatase 1(gene name synonym)|uniprotkb:Adipocyte acid phosphatase(gene name synonym)|uniprotkb:ACP1(gene name)|psi-mi:ACP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004291.1|refseq:NP_009030.1|ensembl:ENSG00000143727(gene)|ensembl:ENST00000272065(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002115(Protein-tyrosine phosphatase, low molecular weight, mammalian)|interpro:IPR017867|interpro:IPR023485|interpro:IPR036196|mint:P24666|rcsb pdb:1XWW|rcsb pdb:3N8I|rcsb pdb:4Z99|rcsb pdb:4Z9A|rcsb pdb:4Z9B|rcsb pdb:5JNR|rcsb pdb:5JNS|rcsb pdb:5JNT|rcsb pdb:5KQG|rcsb pdb:5KQL|rcsb pdb:5KQM|rcsb pdb:5KQP|rcsb pdb:5PNT|rcsb pdb:6Y2V|rcsb pdb:6Y2W|rcsb pdb:7KH8	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:j4VyGaaWO8l/Ah8i1HBU6EnbK289606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62495	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750990|intact:EBI-1047744|uniprotkb:B2R6B4|uniprotkb:D3DQC1|uniprotkb:P46055|uniprotkb:Q5M7Z7|uniprotkb:Q96CG1|ensembl:ENSP00000353741	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:erf1_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)|uniprotkb:ERF1(gene name synonym)|uniprotkb:Protein Cl1(gene name synonym)|uniprotkb:RF1(gene name synonym)|uniprotkb:SUP45L1(gene name synonym)|uniprotkb:TB3-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004721.1|refseq:NP_001243231.1|refseq:NP_001278903.1|refseq:NP_001278904.1|refseq:XP_005271978.1|ensembl:ENSG00000120705(gene)|ensembl:ENST00000360541(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0043022"(ribosome binding)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|mint:P62495|rcsb pdb:1DT9|rcsb pdb:2HST|rcsb pdb:2KTU|rcsb pdb:2KTV|rcsb pdb:2LGT|rcsb pdb:2LLX|rcsb pdb:2MQ6|rcsb pdb:2MQ9|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3JAG|rcsb pdb:3JAH|rcsb pdb:3JAI|rcsb pdb:4D5N|rcsb pdb:4D61|rcsb pdb:5A8L|rcsb pdb:5LZT|rcsb pdb:5LZU|rcsb pdb:5LZV|rcsb pdb:6D90|rcsb pdb:6IP8|rcsb pdb:6XA1|rcsb pdb:6ZME|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q07020	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352694|intact:EBI-8456577|intact:MINT-8429255|uniprotkb:F8VWC5|uniprotkb:Q8WTZ6|ensembl:ENSP00000447001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl18_human(display_long)|uniprotkb:RPL18(gene name)|psi-mi:RPL18(display_short)|uniprotkb:Large ribosomal subunit protein eL18(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000970.1|ensembl:ENSG00000063177(gene)|ensembl:ENST00000549920(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000039(Ribosomal protein L18e)|interpro:IPR021131|interpro:IPR021132|interpro:IPR036227|mint:Q07020|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001257419.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GgzBcLEQgBqbApFlaQIU2jktkAE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60866	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353105|uniprotkb:P17075|uniprotkb:Q5M8S9|uniprotkb:B2R4F4|uniprotkb:B4DW28|ensembl:ENSP00000009589|ensembl:ENSP00000427788|ensembl:ENSP00000503327|ensembl:ENSP00000504123|ensembl:ENSP00000504154|ensembl:ENSP00000504670	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs20_human(display_long)|uniprotkb:RPS20(gene name)|psi-mi:RPS20(display_short)|uniprotkb:Small ribosomal subunit protein uS10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001014.1|refseq:NP_001139699.1|dip:DIP-31245N|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|ensembl:ENSG00000008988(gene)|ensembl:ENST00000009589(transcript)|ensembl:ENST00000521262(transcript)|ensembl:ENST00000676461(transcript)|ensembl:ENST00000676918(transcript)|ensembl:ENST00000678039(transcript)|ensembl:ENST00000678683(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR001848(Ribosomal protein S10)|interpro:IPR005729(Ribosomal protein S10, eukaryotic/archaeal)|interpro:IPR018268|interpro:IPR027486|interpro:IPR036838|mint:P60866|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6xNxX+eP59AOm0KraCysRHUqMFw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09651	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352662|uniprotkb:Q3MIB7|uniprotkb:Q6PJZ7|ensembl:ENSP00000341826|ensembl:ENSP00000503610|uniprotkb:A8K4Z8|intact:EBI-2556572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:roa1_human(display_long)|uniprotkb:HNRNPA1(gene name)|psi-mi:HNRNPA1(display_short)|uniprotkb:HNRPA1(gene name synonym)|uniprotkb:Helix-destabilizing protein(gene name synonym)|uniprotkb:Single-strand RNA-binding protein(gene name synonym)|uniprotkb:hnRNP core protein A1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002127.1|refseq:NP_112420.1|ensembl:ENSG00000135486(gene)|ensembl:ENST00000340913(transcript)|ensembl:ENST00000677210(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|rcsb pdb:2LYV|rcsb pdb:2UP1|rcsb pdb:4YOE|rcsb pdb:5MPG|rcsb pdb:5MPL|rcsb pdb:5ZGD|rcsb pdb:5ZGL|rcsb pdb:6BXX|rcsb pdb:6DCL|rcsb pdb:6J60|rcsb pdb:7BX7|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035198"(miRNA binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051168"(nuclear export)|go:"GO:0051170"(import into nucleus)|go:"GO:0061752"(telomeric repeat-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR034845|interpro:IPR035979|mint:P09651|rcsb pdb:1HA1|rcsb pdb:1L3K|rcsb pdb:1PGZ|rcsb pdb:1PO6|rcsb pdb:1U1K|rcsb pdb:1U1L|rcsb pdb:1U1M|rcsb pdb:1U1N|rcsb pdb:1U1O|rcsb pdb:1U1P|rcsb pdb:1U1Q|rcsb pdb:1U1R|rcsb pdb:1UP1|rcsb pdb:2H4M|refseq:XP_005268883.1|dip:DIP-29338N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ECXjsLRVtNc/aOw90tEFxowHc6c9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q06124	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00410	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09382	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048875|uniprotkb:B2R5E8|uniprotkb:Q9UDK5|ensembl:ENSP00000215909	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:leg1_human(display_long)|uniprotkb:Lectin galactoside-binding soluble 1(gene name synonym)|uniprotkb:Beta-galactoside-binding lectin L-14-I(gene name synonym)|uniprotkb:S-Lac lectin 1(gene name synonym)|uniprotkb:Galaptin(gene name synonym)|uniprotkb:14 kDa lectin(gene name synonym)|uniprotkb:HPL(gene name synonym)|uniprotkb:HBL(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM12(gene name synonym)|uniprotkb:LGALS1(gene name)|psi-mi:LGALS1(display_short)|uniprotkb:Lactose-binding lectin 1(gene name synonym)|uniprotkb:14 kDa laminin-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002296.1|ensembl:ENST00000215909(transcript)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030395"(lactose binding)|ensembl:ENSG00000100097(gene)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR044156|mint:P09382|rcsb pdb:1GZW|rcsb pdb:1W6M|rcsb pdb:1W6N|rcsb pdb:1W6O|rcsb pdb:1W6P|rcsb pdb:1W6Q|rcsb pdb:2KM2|rcsb pdb:2ZKN|rcsb pdb:3OY8|rcsb pdb:3OYW|rcsb pdb:3T2T|rcsb pdb:3W58|rcsb pdb:3W59|rcsb pdb:4Q1P|go:"GO:0031295"(T cell costimulation)|go:"GO:0034120"(positive regulation of erythrocyte aggregation)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043236"(laminin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0048678"(response to axon injury)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4Q1R|rcsb pdb:4Q26|rcsb pdb:4Q27|rcsb pdb:4Q2F|rcsb pdb:4XBL|rcsb pdb:4Y1U|rcsb pdb:4Y1V|rcsb pdb:4Y1X|rcsb pdb:4Y1Y|rcsb pdb:4Y1Z|rcsb pdb:4Y20|rcsb pdb:4Y22|rcsb pdb:4Y24|rcsb pdb:5MWT|rcsb pdb:5MWX|rcsb pdb:6B94|rcsb pdb:6F83|rcsb pdb:6M5Y|reactome:R-HSA-381426|reactome:R-HSA-8957275|dip:DIP-46153N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Sov3RfY2NOjdjuvdFlEd/vaNTMY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17858	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-487243|uniprotkb:Q96A64|uniprotkb:Q96IH4|uniprotkb:Q9BR91|ensembl:ENSP00000269848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfkal_human(display_long)|uniprotkb:PFKL(gene name)|psi-mi:PFKL(display_short)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme B(gene name synonym)|uniprotkb:6-phosphofructokinase type B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002021.2|refseq:NP_002617.3|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P17858|reactome:R-HSA-6798695|reactome:R-HSA-70171|ensembl:ENSG00000141959(gene)|ensembl:ENST00000349048(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lP9/V5WcCl5rLpy4QEZnWkLCCcQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46781	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351206|uniprotkb:Q4QRK7|uniprotkb:Q9BVZ0|ensembl:ENSP00000302896|ensembl:ENSP00000375632|ensembl:ENSP00000375633|ensembl:ENSP00000478449|ensembl:ENSP00000479917|ensembl:ENSP00000480135|ensembl:ENSP00000480662|ensembl:ENSP00000481194|ensembl:ENSP00000481553|ensembl:ENSP00000481655|ensembl:ENSP00000481764|ensembl:ENSP00000481822|ensembl:ENSP00000482023|ensembl:ENSP00000482274|ensembl:ENSP00000482338|ensembl:ENSP00000482475|ensembl:ENSP00000483179|ensembl:ENSP00000484394|uniprotkb:A9C4C1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs9_human(display_long)|uniprotkb:RPS9(gene name)|psi-mi:RPS9(display_short)|uniprotkb:Small ribosomal subunit protein uS4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001004.2|refseq:NP_001308630.1|refseq:NP_001308631.1|refseq:NP_001308633.1|ensembl:ENSG00000170889(gene)|ensembl:ENSG00000274005(gene)|ensembl:ENSG00000274626(gene)|ensembl:ENSG00000274646(gene)|ensembl:ENSG00000274950(gene)|ensembl:ENSG00000275323(gene)|ensembl:ENSG00000277079(gene)|ensembl:ENSG00000277359(gene)|ensembl:ENSG00000278081(gene)|ensembl:ENSG00000278270(gene)|ensembl:ENST00000302907(transcript)|ensembl:ENST00000391752(transcript)|ensembl:ENST00000391753(transcript)|ensembl:ENST00000610826(transcript)|ensembl:ENST00000610953(transcript)|ensembl:ENST00000611921(transcript)|ensembl:ENST00000614737(transcript)|ensembl:ENST00000615346(transcript)|ensembl:ENST00000616082(transcript)|ensembl:ENST00000616536(transcript)|ensembl:ENST00000616839(transcript)|ensembl:ENST00000616877(transcript)|ensembl:ENST00000616928(transcript)|ensembl:ENST00000617291(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000618751(transcript)|go:"GO:0005829"(cytosol)|ensembl:ENST00000619229(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|ensembl:ENST00000620720(transcript)|ensembl:ENST00000620940(transcript)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR001912(Ribosomal protein S4)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005710(Ribosomal protein S4/S9, eukaryotic/archaeal)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|interpro:IPR018079|interpro:IPR022801|interpro:IPR036986|mint:P46781|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|go:"GO:0005634"(nucleus)|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|go:"GO:0005654"(nucleoplasm)|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PGNjkKMs8bMMOSOz2AQvwuCvO1A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H3K6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642537|uniprotkb:A1L454|uniprotkb:A7YDY3|ensembl:ENSP00000331127|ensembl:ENSP00000498355	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bola2_human(display_long)|uniprotkb:BOLA2(gene name)|psi-mi:BOLA2(display_short)|uniprotkb:BOLA2B(gene name)|psi-mi:BOLA2B(display_short)|uniprotkb:BOLA2A(gene name synonym)|uniprotkb:My016(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001026997.1|refseq:NP_001034271.1|refseq:NP_001307508.1|refseq:XP_016855107.1|ensembl:ENSG00000169627(gene)|ensembl:ENSG00000183336(gene)|ensembl:ENST00000330978(transcript)|ensembl:ENST00000651894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR002634(BolA-like protein)|interpro:IPR036065|mint:Q9H3K6|reactome:R-HSA-8950505	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5TcFdmQcwx5trexmXkWp9Arn5zE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O60506	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1024357|uniprotkb:Q53H05|uniprotkb:Q5TCG2|uniprotkb:Q8IW78|uniprotkb:Q8N599|uniprotkb:Q96LC1|uniprotkb:Q96LC2|uniprotkb:Q9Y583|uniprotkb:Q5TCG3|uniprotkb:E1P501|uniprotkb:E1P502|ensembl:ENSP00000358635|ensembl:ENSP00000503783|ensembl:ENSP00000504706	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpq_human(display_long)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:SYNCRIP(gene name)|psi-mi:SYNCRIP(display_short)|uniprotkb:HNRPQ(gene name synonym)|uniprotkb:NSAP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153145.1|refseq:NP_001153146.1|refseq:NP_001153147.1|refseq:NP_001240700.1|refseq:NP_001153148.1|refseq:NP_001153149.1|refseq:NP_006363.4|ensembl:ENSG00000135316(gene)|ensembl:ENST00000369622(transcript)|ensembl:ENST00000676688(transcript)|ensembl:ENST00000678355(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:O60506|rcsb pdb:2DGU|rcsb pdb:2MXT|rcsb pdb:2NBB|rcsb pdb:6KOR|refseq:XP_016865667.1|refseq:XP_005248694.1|dip:DIP-35540N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2rDkXIp/wWzTOoVtN7Bd3uqZo689606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13200	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24752	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1051459|uniprotkb:B2R6H1|uniprotkb:G3XAB4|uniprotkb:Q96FG8|ensembl:ENSP00000265838	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:thil_human(display_long)|uniprotkb:Acetoacetyl-CoA thiolase(gene name synonym)|uniprotkb:T2(gene name synonym)|uniprotkb:ACAT1(gene name)|psi-mi:ACAT1(display_short)|uniprotkb:ACAT(gene name synonym)|uniprotkb:MAT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000010.1|ensembl:ENSG00000075239(gene)|ensembl:ENST00000265838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007420"(brain development)|go:"GO:0009725"(response to hormone)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016453"(C-acetyltransferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0034435"(cholesterol esterification)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046356"(acetyl-CoA catabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072229"(metanephric proximal convoluted tubule development)|go:"GO:0120225"(coenzyme A binding)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1902860"(propionyl-CoA biosynthetic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|rcsb pdb:2F2S|rcsb pdb:2IB7|rcsb pdb:2IB8|rcsb pdb:2IB9|rcsb pdb:2IBU|rcsb pdb:2IBW|rcsb pdb:2IBY|reactome:R-HSA-70895|reactome:R-HSA-77108|reactome:R-HSA-77111	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UYAY+kDdcJqx/hrDFoXH9rgtm/E9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14839-1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5279755|ensembl:ENSP00000440542	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q14839-1(display_long)|uniprotkb:CHD4(gene name)|psi-mi:CHD4(display_short)|uniprotkb:ATP-dependent helicase CHD4(gene name synonym)|uniprotkb:Mi-2 autoantigen 218 kDa protein(gene name synonym)|uniprotkb:Mi2-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	intact:EBI-372916(isoform-parent)|ensembl:ENSG00000111642(gene)|ensembl:ENST00000544040(transcript)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:E9eHT/41SIFRiz54J81hvPQeHIE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31943	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11717	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96AE4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711404|uniprotkb:Q12828|ensembl:ENSP00000359804	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp1_human(display_long)|uniprotkb:FUBP1(gene name)|psi-mi:FUBP1(display_short)|uniprotkb:DNA helicase V(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q96AE4|rcsb pdb:1J4W|rcsb pdb:2KXH|rcsb pdb:4LIJ|rcsb pdb:6Y24|rcsb pdb:6Y2C|rcsb pdb:6Y2D|ensembl:ENSG00000162613(gene)|ensembl:ENST00000370768(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|refseq:NP_003893.2|refseq:NP_001290362.1|refseq:XP_016858232.1|dip:DIP-47273N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:38IaQgYv8qLMAryXO0lbfzgjjsM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43633	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2692789|uniprotkb:B2R4W6|uniprotkb:Q3ZTT0|ensembl:ENSP00000310440|ensembl:ENSP00000469240|ensembl:ENSP00000472680	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:chm2a_human(display_long)|uniprotkb:BC2(gene name synonym)|uniprotkb:CHMP2(gene name synonym)|uniprotkb:Chromatin-modifying protein 2a(gene name synonym)|uniprotkb:Putative breast adenocarcinoma marker BC-2(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-1(gene name synonym)|uniprotkb:CHMP2A(gene name)|psi-mi:CHMP2A(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055268.1|refseq:NP_940818.1|ensembl:ENSG00000130724(gene)|ensembl:ENST00000312547(transcript)|ensembl:ENST00000600118(transcript)|ensembl:ENST00000601220(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010324"(membrane invagination)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:O43633|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-432720|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-48533N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:S5uZThg//3igYMf6LLYDJ/FVGRA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62888	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353116|uniprotkb:P04645|uniprotkb:Q502Z6|ensembl:ENSP00000287038|ensembl:ENSP00000428085|uniprotkb:B2R591	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl30_human(display_long)|uniprotkb:RPL30(gene name)|psi-mi:RPL30(display_short)|uniprotkb:Large ribosomal subunit protein eL30(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000156482(gene)|ensembl:ENST00000287038(transcript)|ensembl:ENST00000521291(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000231(Ribosomal protein L30e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR022991|interpro:IPR029064|interpro:IPR039109|mint:P62888|rcsb pdb:3VI6|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000980.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xR9LwYg6N7m9njT1pYumOPKZVu49606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62269	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352451|ensembl:ENSP00000211372|ensembl:ENSP00000393241|ensembl:ENSP00000403175|ensembl:ENSP00000412583|ensembl:ENSP00000416110|uniprotkb:P25232|uniprotkb:Q6IPF8|uniprotkb:Q5SUJ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs18_human(display_long)|uniprotkb:RPS18(gene name)|psi-mi:RPS18(display_short)|uniprotkb:D6S218E(gene name synonym)|uniprotkb:Ke-3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS13(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_072045.1|ensembl:ENSG00000096150(gene)|ensembl:ENSG00000223367(gene)|ensembl:ENSG00000226225(gene)|ensembl:ENSG00000231500(gene)|ensembl:ENSG00000235650(gene)|ensembl:ENST00000211372(transcript)|ensembl:ENST00000434122(transcript)|ensembl:ENST00000439602(transcript)|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENST00000454021(transcript)|ensembl:ENST00000457341(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62269|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|dip:DIP-32892N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yOHgKM/BuvgGdqp1OEVPeuiABg89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14174	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372712|uniprotkb:A5Z1R8|uniprotkb:B2R4S3|uniprotkb:Q6FHV0|uniprotkb:Q2V4Y5|ensembl:ENSP00000215754|ensembl:ENSP00000482779	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mif_human(display_long)|uniprotkb:MIF(gene name)|psi-mi:MIF(display_short)|uniprotkb:MMIF(gene name synonym)|uniprotkb:GLIF(gene name synonym)|uniprotkb:Phenylpyruvate tautomerase(gene name synonym)|uniprotkb:Glycosylation-inhibiting factor(gene name synonym)|uniprotkb:L-dopachrome tautomerase(gene name synonym)|uniprotkb:L-dopachrome isomerase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002406.1|ensembl:ENST00000215754(transcript)|ensembl:ENST00000613839(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004167"(dopachrome isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000276701(gene)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031982"(vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000240972(gene)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045087"(innate immune response)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050178"(phenylpyruvate tautomerase activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001398(Macrophage migration inhibitory factor)|interpro:IPR014347(Tautomerase)|interpro:IPR019829|mint:P14174|rcsb pdb:1CGQ|rcsb pdb:1GCZ|rcsb pdb:1GD0|rcsb pdb:1GIF|rcsb pdb:1LJT|rcsb pdb:1MIF|rcsb pdb:1P1G|rcsb pdb:2OOH|rcsb pdb:2OOW|rcsb pdb:2OOZ|rcsb pdb:3B9S|rcsb pdb:3CE4|rcsb pdb:3DJH|rcsb pdb:3DJI|rcsb pdb:3HOF|rcsb pdb:3IJG|rcsb pdb:3IJJ|rcsb pdb:3JSF|rcsb pdb:3JSG|rcsb pdb:3JTU|rcsb pdb:3L5P|rcsb pdb:3L5R|rcsb pdb:3L5S|rcsb pdb:3L5T|rcsb pdb:3L5U|rcsb pdb:3L5V|rcsb pdb:3SMB|rcsb pdb:3SMC|rcsb pdb:3U18|rcsb pdb:3WNR|rcsb pdb:3WNS|rcsb pdb:3WNT|rcsb pdb:4ETG|rcsb pdb:4EUI|rcsb pdb:4EVG|rcsb pdb:4F2K|rcsb pdb:4GRN|rcsb pdb:4GRO|rcsb pdb:4GRP|rcsb pdb:4GRQ|rcsb pdb:4GRR|rcsb pdb:4GRU|rcsb pdb:4GUM|rcsb pdb:4K9G|rcsb pdb:4OSF|rcsb pdb:4OYQ|rcsb pdb:4P01|rcsb pdb:4P0H|rcsb pdb:4PKK|rcsb pdb:4PKZ|rcsb pdb:4PLU|rcsb pdb:4TRF|rcsb pdb:4TRU|rcsb pdb:4WR8|rcsb pdb:4WRB|rcsb pdb:4XX7|rcsb pdb:4XX8|rcsb pdb:4Z15|rcsb pdb:4Z1T|rcsb pdb:4Z1U|rcsb pdb:5B4O|rcsb pdb:5BS9|rcsb pdb:5BSC|rcsb pdb:5BSI|rcsb pdb:5BSJ|rcsb pdb:5EIZ|rcsb pdb:5HVS|rcsb pdb:5HVT|rcsb pdb:5HVV|rcsb pdb:5J7P|rcsb pdb:5J7Q|rcsb pdb:5UMJ|rcsb pdb:5UMK|rcsb pdb:5UZY|rcsb pdb:5V70|rcsb pdb:5V73|rcsb pdb:5XEJ|rcsb pdb:1CA7|rcsb pdb:6B1C|rcsb pdb:6B1K|rcsb pdb:6B2C|rcsb pdb:6BG6|rcsb pdb:6BG7|rcsb pdb:6CB5|rcsb pdb:6CBF|rcsb pdb:6CBG|rcsb pdb:6FVE|rcsb pdb:6FVH|rcsb pdb:6OY8|rcsb pdb:6OYB|rcsb pdb:6OYE|rcsb pdb:6OYG|rcsb pdb:6PEG|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-8950505|rcsb pdb:6CBH|dip:DIP-31137N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Vk+Sfaz5c59y8dKKJ4Qn+7fjwvQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A5YKK6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222758|uniprotkb:Q68DX7|uniprotkb:Q7Z3K2|uniprotkb:Q8IWB8|uniprotkb:Q8TB53|uniprotkb:Q9BVZ6|uniprotkb:Q9UFR8|uniprotkb:Q9UI27|uniprotkb:Q9Y2L0|intact:EBI-2561986|ensembl:ENSP00000320949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cnot1_human(display_long)|uniprotkb:CNOT1(gene name)|psi-mi:CNOT1(display_short)|uniprotkb:CDC39(gene name synonym)|uniprotkb:KIAA1007(gene name synonym)|uniprotkb:NOT1(gene name synonym)|uniprotkb:Negative regulator of transcription subunit 1 homolog(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:AD-005(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057368.3|refseq:NP_996882.1|refseq:NP_001252541.1|dip:DIP-44954N|ensembl:ENSG00000125107(gene)|ensembl:ENST00000317147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|mint:A5YKK6|rcsb pdb:4C0D|rcsb pdb:4CQO|rcsb pdb:4CRU|rcsb pdb:4CRV|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT6|rcsb pdb:4CT7|rcsb pdb:4GMJ|rcsb pdb:4GML|rcsb pdb:4J8S|rcsb pdb:5ANR|rcsb pdb:5FU6|rcsb pdb:5FU7|rcsb pdb:5ONA|reactome:R-HSA-429947|reactome:R-HSA-6804115	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qYUeacTR9wuDH02Uy8CqCcaaXOY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14818	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-603272|uniprotkb:Q9BR53|uniprotkb:Q9H4K5|uniprotkb:Q9UEU8|uniprotkb:B2R515|uniprotkb:Q5JXJ2|ensembl:ENSP00000359910	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa7_human(display_long)|uniprotkb:PSMA7(gene name)|psi-mi:PSMA7(display_short)|uniprotkb:Proteasome subunit RC6-1(gene name synonym)|uniprotkb:Proteasome subunit XAPC7(gene name synonym)|uniprotkb:HSPC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002783.1|dip:DIP-29363N|ensembl:ENSG00000101182(gene)|ensembl:ENST00000370873(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098794"(postsynapse)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035190|mint:O14818|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:J1M+b+VK02BAn2OnZISjjlmO8dc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08107	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6PKG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08865	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354112|uniprotkb:Q6NSD1|uniprotkb:Q6NXQ8|uniprotkb:Q86VC0|uniprotkb:P11085|uniprotkb:P12030|uniprotkb:Q16471|uniprotkb:Q6IPD1|uniprotkb:Q6IPD2|ensembl:ENSP00000346067	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rssa_human(display_long)|uniprotkb:RPSA(gene name)|psi-mi:RPSA(display_short)|uniprotkb:LAMBR(gene name synonym)|uniprotkb:LAMR1(gene name synonym)|uniprotkb:Laminin receptor 1(gene name synonym)|uniprotkb:37/67 kDa laminin receptor(gene name synonym)|uniprotkb:Laminin-binding protein precursor p40(gene name synonym)|uniprotkb:Colon carcinoma laminin-binding protein(gene name synonym)|uniprotkb:NEM/1CHD4(gene name synonym)|uniprotkb:Multidrug resistance-associated protein MGr1-Ag(gene name synonym)|uniprotkb:37 kDa laminin receptor precursor(gene name synonym)|uniprotkb:67 kDa laminin receptor(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002286.2|refseq:NP_001291217.1|dip:DIP-32878N|ensembl:ENSG00000168028(gene)|ensembl:ENST00000301821(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0007155"(cell adhesion)|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZOJ|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0043022"(ribosome binding)|go:"GO:0043236"(laminin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001865(Ribosomal protein S2)|interpro:IPR005707(Ribosomal protein S2, eukaryotic/archaeal)|interpro:IPR018130|interpro:IPR023591|interpro:IPR027498|interpro:IPR027504|interpro:IPR032281|mint:P08865|rcsb pdb:3BCH|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Jpv3I3G5C297fHfNwIqyB9Pf8/A9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13895	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358049|uniprotkb:Q6P5W4|uniprotkb:Q86W44|uniprotkb:Q96IP8|ensembl:ENSP00000230340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:byst_human(display_long)|uniprotkb:BYSL(gene name)|psi-mi:BYSL(display_short)|uniprotkb:ENP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004044.3|dip:DIP-50092N|ensembl:ENSG00000112578(gene)|ensembl:ENST00000230340(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045177"(apical part of cell)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR007955(Bystin)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QdpF9XYm2gFc5ZodqaGvqTM6XNk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63104	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01813	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359022|uniprotkb:B3KS15|uniprotkb:Q5VSR7|uniprotkb:Q5VSR8|ensembl:ENSP00000370517	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfkap_human(display_long)|uniprotkb:PFKP(gene name)|psi-mi:PFKP(display_short)|uniprotkb:PFKF(gene name synonym)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme C(gene name synonym)|uniprotkb:6-phosphofructokinase type C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002618.1|ensembl:ENSG00000067057(gene)|ensembl:ENST00000381125(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:Q01813|rcsb pdb:4RH3|rcsb pdb:4U1R|rcsb pdb:4WL0|rcsb pdb:4XYJ|rcsb pdb:4XYK|rcsb pdb:4XZ2|reactome:R-HSA-70171|refseq:NP_001229268.1|dip:DIP-45850N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GNmWbFrQsTMRdVphWG+3DK3wxaA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49406	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1188518|uniprotkb:Q96Q52|uniprotkb:Q53TX9|ensembl:ENSP00000377486|ensembl:ENSP00000387284	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rm19_human(display_long)|uniprotkb:MRPL15(gene name synonym)|uniprotkb:39S ribosomal protein L15, mitochondrial(gene name synonym)|uniprotkb:MRPL19(gene name)|psi-mi:MRPL19(display_short)|uniprotkb:KIAA0104(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein bL19m(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055578.2|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7O9M|ensembl:ENSG00000115364(gene)|ensembl:ENST00000393909(transcript)|ensembl:ENST00000409374(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR001857(Ribosomal protein L19)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR038657|mint:P49406|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4ZCZpq3u9wkdpuNVFpk+bhceaW09606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P78344	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-296519|uniprotkb:O60877|uniprotkb:P78404|uniprotkb:Q0VH00|uniprotkb:Q53EU1|uniprotkb:Q58EZ2|uniprotkb:Q8NI71|uniprotkb:Q96C16|ensembl:ENSP00000340281|ensembl:ENSP00000433371|ensembl:ENSP00000433664|uniprotkb:Q0VH01|uniprotkb:Q2NKW9|uniprotkb:Q49A79	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4g2_human(display_long)|uniprotkb:EIF4G2(gene name)|psi-mi:EIF4G2(display_short)|uniprotkb:DAP5(gene name synonym)|uniprotkb:OK/SW-cl.75(orf name)|uniprotkb:p97(gene name synonym)|uniprotkb:Death-associated protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000110321(gene)|ensembl:ENST00000339995(transcript)|ensembl:ENST00000525681(transcript)|ensembl:ENST00000526148(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007507"(heart development)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008219"(cell death)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:P78344|rcsb pdb:3D3M|rcsb pdb:3L6A|rcsb pdb:4IUL|reactome:R-HSA-1169408|refseq:NP_001036024.3|refseq:NP_001166176.1|refseq:NP_001409.3|dip:DIP-31366N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UIE1Um0s2KJ9hpaa9X6kfZ8enPc9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14839-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190797|ensembl:ENSP00000496634	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q14839-2(display_long)|uniprotkb:CHD4(gene name)|psi-mi:CHD4(display_short)|uniprotkb:ATP-dependent helicase CHD4(gene name synonym)|uniprotkb:Mi-2 autoantigen 218 kDa protein(gene name synonym)|uniprotkb:Mi2-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	intact:EBI-372916(isoform-parent)|ensembl:ENSG00000111642(gene)|ensembl:ENST00000645095(transcript)|uniprotkb:Q14839-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Msvk6YtgmdEXu9Kvatu7Qghc4BM9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04843	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50402	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P38159	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-743526|ensembl:ENSP00000359645|uniprotkb:Q5JQ67|uniprotkb:Q969R3|uniprotkb:D3DWH0|uniprotkb:E9PG86|uniprotkb:Q8N8Y7|uniprotkb:B4E3U4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rbmx_human(display_long)|uniprotkb:Glycoprotein p43(gene name synonym)|uniprotkb:RBMX(gene name)|psi-mi:RBMX(display_short)|uniprotkb:HNRPG(gene name synonym)|uniprotkb:RBMXP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein G(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000147274(gene)|ensembl:ENST00000320676(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012604(RBM1CTR)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P38159|rcsb pdb:2MB0|rcsb pdb:2MKS|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:NP_002130.2|refseq:NP_001158275.1|dip:DIP-34447N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ocCkdy9PxjeVLUQf0tMVCEhFfO89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96I24	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-954200|ensembl:ENSP00000318177|uniprotkb:Q92946|uniprotkb:Q9BVB6|intact:EBI-1760333|intact:EBI-1965411|uniprotkb:A3KFL0|uniprotkb:A3KFK8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fubp3_human(display_long)|uniprotkb:FUBP3(gene name)|psi-mi:FUBP3(display_short)|uniprotkb:FBP3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000107164(gene)|ensembl:ENST00000319725(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q96I24|refseq:NP_003925.1|dip:DIP-50124N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xdCa+teqFaSxKNTpCJWQ5gcd0sQ9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62829	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353303|uniprotkb:P23131|uniprotkb:Q3SWV7|uniprotkb:P24048|uniprotkb:Q29246|uniprotkb:Q6P5S1|ensembl:ENSP00000377865|ensembl:ENSP00000420311	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl23_human(display_long)|uniprotkb:RPL23(gene name)|psi-mi:RPL23(display_short)|uniprotkb:60S ribosomal protein L17(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL14(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|reactome:R-HSA-9010553|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|refseq:NP_000969.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62829|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|ensembl:ENSG00000125691(gene)|ensembl:ENST00000394332(transcript)|ensembl:ENST00000479035(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005730"(nucleolus)|dip:DIP-33156N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04075	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39019	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354451|ensembl:ENSP00000469228|ensembl:ENSP00000470004|ensembl:ENSP00000470972	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs19_human(display_long)|uniprotkb:RPS19(gene name)|psi-mi:RPS19(display_short)|uniprotkb:Small ribosomal subunit protein eS19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001013.1|ensembl:ENSG00000105372(gene)|ensembl:ENST00000593863(transcript)|ensembl:ENST00000598742(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003723"(RNA binding)|ensembl:ENST00000600467(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0007000"(nucleolus organization)|go:"GO:0009991"(response to extracellular stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060265"(positive regulation of respiratory burst involved in inflammatory response)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001266(Ribosomal protein S19e)|interpro:IPR018277|interpro:IPR036388|interpro:IPR036390|mint:P39019|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001308412.1|refseq:NP_001308413.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3YqdJJJG+2nqoBf3PLu1fs7pVkY9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y5K6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63244	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BSJ8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355956|ensembl:ENSP00000377612|uniprotkb:A0FGR7|uniprotkb:A8K2S2|uniprotkb:O94848|uniprotkb:Q6PJN4|uniprotkb:Q9H6J1|uniprotkb:Q9H6W2|uniprotkb:Q9Y416|intact:EBI-4399548	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:esyt1_human(display_long)|uniprotkb:KIAA0747(gene name synonym)|uniprotkb:MBC2(gene name synonym)|uniprotkb:ESYT1(gene name)|psi-mi:ESYT1(display_short)|uniprotkb:Membrane-bound C2 domain-containing protein(gene name synonym)|uniprotkb:FAM62A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR037752|interpro:IPR039010|mint:Q9BSJ8|reactome:R-HSA-1660662|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9035034|interpro:IPR037749|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037733|go:"GO:0005544"(calcium-dependent phospholipid binding)|ensembl:ENSG00000139641(gene)|ensembl:ENST00000394048(transcript)|go:"GO:0005509"(calcium ion binding)|refseq:NP_001171725.1|refseq:NP_056107.1|dip:DIP-57197N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MYbYK3357LLH0TP1qU7CsvJenGk9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UNM6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356070|uniprotkb:O75831|uniprotkb:Q9UNV3|uniprotkb:Q53XU2|intact:EBI-1058479|uniprotkb:B3KT15|ensembl:ENSP00000436186	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd13_human(display_long)|uniprotkb:PSMD13(gene name)|psi-mi:PSMD13(display_short)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002808.3|refseq:NP_787128.2|dip:DIP-27576N|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:6MSK|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000185627(gene)|ensembl:ENST00000532097(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007127"(meiosis I)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|mint:Q9UNM6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iOxE62MMeGx+aqsrir/LukJqeho9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4E386	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189985	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4e386_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|refseq:NP_001290458.1|refseq:NP_001290459.1|interpro:IPR023123|interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|interpro:IPR037103	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:prJej5wjji2EkLUy3KTAIdRbnnw9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11586	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709638|uniprotkb:Q86VC9|uniprotkb:Q9BVP5|uniprotkb:B2R5Y2|uniprotkb:G3V2B8|intact:EBI-21358459|uniprotkb:A0A024R652|uniprotkb:A0A384N5Y3|ensembl:ENSP00000498336|ensembl:ENSP00000498511	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:c1tc_human(display_long)|uniprotkb:MTHFD1(gene name)|psi-mi:MTHFD1(display_short)|uniprotkb:MTHFC(gene name synonym)|uniprotkb:MTHFD(gene name synonym)|uniprotkb:Epididymis secretory sperm binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005947.3|dip:DIP-33682N|ensembl:ENSG00000100714(gene)|ensembl:ENST00000651537(transcript)|ensembl:ENST00000652337(transcript)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR027417|interpro:IPR036291|mint:P11586|rcsb pdb:1A4I|rcsb pdb:1DIA|rcsb pdb:1DIB|rcsb pdb:1DIG|rcsb pdb:6ECP|rcsb pdb:6ECQ|rcsb pdb:6ECR|reactome:R-HSA-196757	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6ZizfpjVcaL5WNxKXL7qJpw59PI9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H583	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048716|uniprotkb:Q5T3Q8|uniprotkb:Q6P197|uniprotkb:Q9NW23|ensembl:ENSP00000355541	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:heat1_human(display_long)|uniprotkb:Protein BAP28(gene name synonym)|uniprotkb:HEATR1(gene name)|psi-mi:HEATR1(display_short)|uniprotkb:BAP28(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein 10 homolog(gene name synonym)|uniprotkb:UTP10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060542.4|ensembl:ENSG00000119285(gene)|ensembl:ENST00000366582(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034455"(t-UTP complex)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012954(BP28, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022125|interpro:IPR040191|mint:Q9H583|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0WoP84UUVfXWppmvCYa/n5GTzc89606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16891	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N983	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1043145|ensembl:ENSP00000315364|uniprotkb:Q5JW06|uniprotkb:Q7Z719|uniprotkb:Q7Z7H6|uniprotkb:Q86XN1|uniprotkb:Q9BYC7|uniprotkb:B1AL09|uniprotkb:B1AL07|uniprotkb:B1AL10|intact:EBI-1047104|uniprotkb:D3DR71|uniprotkb:B1AL06|uniprotkb:C9J5Q3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rm43_human(display_long)|uniprotkb:Mitochondrial ribosomal protein bMRP36a(gene name synonym)|uniprotkb:MRPL43(gene name)|psi-mi:MRPL43(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|ensembl:ENSG00000055950(gene)|ensembl:ENST00000318325(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR036249|interpro:IPR039927|mint:Q8N983|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:7A5I|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|refseq:NP_789764.1|refseq:XP_006718098.1|refseq:NP_115488.2|refseq:NP_789762.1|refseq:NP_789763.1|refseq:NP_001295325.1|ensembl:ENST00000299179|ensembl:ENSP00000299179|ensembl:ENSP00000315364|ensembl:ENST00000318364|ensembl:ENSP00000315948|ensembl:ENST00000342071|ensembl:ENSP00000339844|ensembl:ENST00000370234|ensembl:ENSP00000359254|ensembl:ENST00000370236|ensembl:ENSP00000359256|ensembl:ENST00000370242|ensembl:ENSP00000359262|refseq:XP_005270288.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:p3wPkljBAhx4IwvXsvfXDaEvpag9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15559	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191068|imex:IM-17358-5|pride:19286|pride:19296|pride:19287	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a C-terminal domain truncated version (X4C0) of alpha-4 integrin."|caution:[EBI-6190037] The protein has been merged with EBI-1055615 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2021/06/18	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	intact-crc:0FA18FEE4224C190|rigid:HpDvlbXU5gCiGihgO0QzPuvfr9Q	false	fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52594	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6P2Q9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I0ot8b3pvieXRI66omFm145sGVA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27694	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-621389|ensembl:ENSP00000254719|uniprotkb:Q59ES9|uniprotkb:A8K0Y9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rfa1_human(display_long)|uniprotkb:Replication factor A protein 1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:RPA1(gene name)|psi-mi:RPA1(display_short)|uniprotkb:REPA1(gene name synonym)|uniprotkb:RPA70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000132383(gene)|ensembl:ENST00000254719(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016605"(PML body)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|go:"GO:0006268"(DNA unwinding involved in DNA replication)|mint:P27694|rcsb pdb:1EWI|rcsb pdb:1FGU|rcsb pdb:1JMC|rcsb pdb:1L1O|rcsb pdb:2B29|rcsb pdb:2B3G|rcsb pdb:4IJH|rcsb pdb:4IJL|rcsb pdb:4IPC|rcsb pdb:4IPD|rcsb pdb:4IPG|rcsb pdb:4IPH|rcsb pdb:4LUO|rcsb pdb:4LUV|rcsb pdb:4LUZ|rcsb pdb:4LW1|rcsb pdb:4LWC|rcsb pdb:4NB3|rcsb pdb:4O0A|rcsb pdb:4R4C|rcsb pdb:4R4I|rcsb pdb:4R4O|rcsb pdb:4R4Q|rcsb pdb:4R4T|rcsb pdb:5E7N|rcsb pdb:5EAY|rcsb pdb:5N85|rcsb pdb:5N8A|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-3108214|refseq:NP_002936.1|dip:DIP-24189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DRZpMUlGyS0Qa5XFEtx71k0iPig9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q00059	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15126	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055562|uniprotkb:Q5TZW9|ensembl:ENSP00000357452	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pmvk_human(display_long)|uniprotkb:PMVK(gene name)|psi-mi:PMVK(display_short)|uniprotkb:PMKI(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006547.1|ensembl:ENSG00000163344(gene)|ensembl:ENST00000368467(transcript)|go:"GO:0004631"(phosphomevalonate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0019287"(isopentenyl diphosphate biosynthetic process, mevalonate pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070723"(response to cholesterol)|interpro:IPR005919(Higher eukaryotic phosphomevalonate kinase)|interpro:IPR027417|mint:Q15126|rcsb pdb:3CH4|reactome:R-HSA-191273|reactome:R-HSA-2426168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bDsF+xduPQB+HVXbNikncal5foo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46109	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31151	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357520|uniprotkb:Q6FGE3|uniprotkb:Q5SY67|uniprotkb:Q9H1E2|ensembl:ENSP00000357711|ensembl:ENSP00000357712	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:s10a7_human(display_long)|uniprotkb:S100A7(gene name)|psi-mi:S100A7(display_short)|uniprotkb:PSOR1(gene name synonym)|uniprotkb:S100A7C(gene name synonym)|uniprotkb:S100 calcium-binding protein A7(gene name synonym)|uniprotkb:Psoriasin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000143556(gene)|ensembl:ENST00000368722(transcript)|ensembl:ENST00000368723(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008544"(epidermis development)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051238"(sequestering of metal ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071624"(positive regulation of granulocyte chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028477|interpro:IPR034325|mint:P31151|rcsb pdb:1PSR|rcsb pdb:2PSR|rcsb pdb:2WND|rcsb pdb:2WOR|rcsb pdb:2WOS|rcsb pdb:3PSR|rcsb pdb:4AQJ|reactome:R-HSA-6798695|reactome:R-HSA-6799990|refseq:NP_002954.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/v8+XQ7rCMTYzq9k/KqjcSm/G0A9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q01082	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351561|intact:EBI-1642531|uniprotkb:O60837|uniprotkb:Q16057|uniprotkb:Q53R99|uniprotkb:Q59ER3|uniprotkb:Q8IX99|uniprotkb:B2RP63|ensembl:ENSP00000349259	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sptb2_human(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:SPTB2(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 1(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003119.2|refseq:NP_842565.2|ensembl:ENSG00000115306(gene)|ensembl:ENST00000356805(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q01082|rcsb pdb:1AA2|rcsb pdb:1BKR|rcsb pdb:3EDV|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9703465|reactome:R-HSA-373753|refseq:XP_005264574.1|refseq:XP_006712150.1|refseq:XP_016860268.1|refseq:XP_016860269.1|refseq:XP_016860270.1|dip:DIP-33182N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rQJxsoEirg87umLjsEwHcQ0/blQ9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12906	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13057	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-745967|uniprotkb:Q6GS23|uniprotkb:Q8NBM7|uniprotkb:Q8NEW1|uniprotkb:Q8WXD4|uniprotkb:Q9NRM3|uniprotkb:B2RA78|uniprotkb:B4DLU0|ensembl:ENSP00000377406|ensembl:ENSP00000393564	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:coasy_human(display_long)|uniprotkb:NBP(gene name synonym)|uniprotkb:POV-2(gene name synonym)|uniprotkb:COASY(gene name)|psi-mi:COASY(display_short)|uniprotkb:PSEC0106(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035994.1|refseq:NP_001035997.2|refseq:NP_079509.5|refseq:XP_011523602.1|ensembl:ENSG00000068120(gene)|ensembl:ENST00000393818(transcript)|ensembl:ENST00000421097(transcript)|go:"GO:0004140"(dephospho-CoA kinase activity)|go:"GO:0004595"(pantetheine-phosphate adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001977(Dephospho-CoA kinase)|interpro:IPR004821(Cytidyltransferase-related)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR027417|reactome:R-HSA-196783|refseq:XP_006722179.1|refseq:XP_016880657.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yMK1IODpj01+JZsNsayJCgEHpyo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36873	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356283|ensembl:ENSP00000335084	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1g_human(display_long)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0004721"(phosphoprotein phosphatase activity)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000335007(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0043197"(dendritic spine)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P36873|rcsb pdb:1IT6|rcsb pdb:1JK7|rcsb pdb:1U32|rcsb pdb:2BCD|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|rcsb pdb:2BDX|rcsb pdb:4UT2|rcsb pdb:4UT3|go:"GO:0046872"(metal ion binding)|rcsb pdb:5INB|go:"GO:0047485"(protein N-terminus binding)|rcsb pdb:5J28|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|reactome:R-HSA-141444|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-9648025|reactome:R-HSA-9660537|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-400253|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-68877|refseq:NP_001231903.1|refseq:NP_002701.1|dip:DIP-749N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SyjV/4d9V8lV/BXub2KESPKvupA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06748	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78579|uniprotkb:P08693|uniprotkb:Q12826|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q14115|uniprotkb:Q5EU94|uniprotkb:Q5EU95|uniprotkb:Q5EU96|uniprotkb:Q5EU97|uniprotkb:Q5EU98|uniprotkb:Q5EU99|uniprotkb:Q6V962|uniprotkb:Q8WTW5|uniprotkb:Q96AT6|uniprotkb:Q96DC4|uniprotkb:Q96EA5|uniprotkb:A8K3N7|uniprotkb:B5BU00|uniprotkb:Q9UDJ7|uniprotkb:D3DQL6|uniprotkb:Q9BYG9|ensembl:ENSP00000296930|ensembl:ENSP00000428755	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:npm_human(display_long)|uniprotkb:NPM1(gene name)|psi-mi:NPM1(display_short)|uniprotkb:NPM(gene name synonym)|uniprotkb:Nucleolar phosphoprotein B23(gene name synonym)|uniprotkb:Numatrin(gene name synonym)|uniprotkb:Nucleolar protein NO38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002511.1|refseq:NP_954654.1|refseq:NP_001032827.1|dip:DIP-30932N|ensembl:ENSG00000181163(gene)|ensembl:ENST00000296930(transcript)|ensembl:ENST00000517671(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001652"(granular component)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019843"(rRNA binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042255"(ribosome assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060699"(regulation of endoribonuclease activity)|go:"GO:0060735"(regulation of eIF2 alpha phosphorylation by dsRNA)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902629"(regulation of mRNA stability involved in cellular response to UV)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR032569|interpro:IPR036824|mint:P06748|rcsb pdb:2LLH|rcsb pdb:2P1B|rcsb pdb:2VXD|rcsb pdb:5EHD|reactome:R-HSA-180746|reactome:R-HSA-3899300|reactome:R-HSA-606279|reactome:R-HSA-6804115|reactome:R-HSA-8869496	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HJ7Mg+XsIhuJiScPKiI0dIa6KpM9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3B4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1046261|ensembl:ENSP00000233468|uniprotkb:Q53TM1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf3b6_human(display_long)|uniprotkb:SF3B6(gene name)|psi-mi:SF3B6(display_short)|uniprotkb:Pre-mRNA branch site protein p14(gene name synonym)|uniprotkb:SAP14(gene name synonym)|uniprotkb:SF3B14(gene name synonym)|uniprotkb:SF3B14A(gene name synonym)|uniprotkb:SF3b 14 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein, 14-kDa(gene name synonym)|uniprotkb:Splicing factor 3b, subunit 6, 14kDa(gene name synonym)|uniprotkb:CGI-110(orf name)|uniprotkb:HSPC175(orf name)|uniprotkb:HT006(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000233468(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000115128(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034150|interpro:IPR035979|mint:Q9Y3B4|rcsb pdb:2F9D|rcsb pdb:2F9J|rcsb pdb:2FHO|rcsb pdb:3LQV|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_057131.1|dip:DIP-44132N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7mhaXkmVqjfJGPdX1UDM+kN4vNI9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95373	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26583	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057009|uniprotkb:Q5U072|uniprotkb:D3DP37|uniprotkb:B2R4K8|ensembl:ENSP00000296503|ensembl:ENSP00000393448|ensembl:ENSP00000404912	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmgb2_human(display_long)|uniprotkb:HMGB2(gene name)|psi-mi:HMGB2(display_short)|uniprotkb:HMG2(gene name synonym)|uniprotkb:High mobility group protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001124160.1|refseq:NP_001124161.1|refseq:NP_002120.1|ensembl:ENSG00000164104(gene)|ensembl:ENST00000296503(transcript)|ensembl:ENST00000438704(transcript)|ensembl:ENST00000446922(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032075"(positive regulation of nuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042056"(chemoattractant activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044378"(non-sequence-specific DNA binding, bending)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR036910|mint:P26583|reactome:R-HSA-140342	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ACzaSeIwT3vM4ZgpCSSlzA6nd4U9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02649	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35232	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15056	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748492|uniprotkb:A8K3R1|uniprotkb:D3DXF6|uniprotkb:D3DXF8|ensembl:ENSP00000265753	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4h_human(display_long)|uniprotkb:Williams-Beuren syndrome chromosomal region 1 protein(gene name synonym)|uniprotkb:EIF4H(gene name)|psi-mi:EIF4H(display_short)|uniprotkb:WBSCR1(gene name synonym)|uniprotkb:KIAA0038(gene name synonym)|uniprotkb:WSCR1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_071496.1|refseq:NP_114381.1|ensembl:ENSG00000106682(gene)|ensembl:ENST00000265753(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0019953"(sexual reproduction)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034057"(RNA strand-exchange activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048589"(developmental growth)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034229|interpro:IPR035979|mint:Q15056|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dNPoAzwFD5lFwCMnRl0cbXM3j8s9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N983	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1043145|ensembl:ENSP00000315364|uniprotkb:Q5JW06|uniprotkb:Q7Z719|uniprotkb:Q7Z7H6|uniprotkb:Q86XN1|uniprotkb:Q9BYC7|uniprotkb:B1AL09|uniprotkb:B1AL07|uniprotkb:B1AL10|intact:EBI-1047104|uniprotkb:D3DR71|uniprotkb:B1AL06|uniprotkb:C9J5Q3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rm43_human(display_long)|uniprotkb:Mitochondrial ribosomal protein bMRP36a(gene name synonym)|uniprotkb:MRPL43(gene name)|psi-mi:MRPL43(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|ensembl:ENSG00000055950(gene)|ensembl:ENST00000318325(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR036249|interpro:IPR039927|mint:Q8N983|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:7A5I|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|refseq:NP_789764.1|refseq:XP_006718098.1|refseq:NP_115488.2|refseq:NP_789762.1|refseq:NP_789763.1|refseq:NP_001295325.1|ensembl:ENST00000299179|ensembl:ENSP00000299179|ensembl:ENSP00000315364|ensembl:ENST00000318364|ensembl:ENSP00000315948|ensembl:ENST00000342071|ensembl:ENSP00000339844|ensembl:ENST00000370234|ensembl:ENSP00000359254|ensembl:ENST00000370236|ensembl:ENSP00000359256|ensembl:ENST00000370242|ensembl:ENSP00000359262|refseq:XP_005270288.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:p3wPkljBAhx4IwvXsvfXDaEvpag9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-923010|uniprotkb:Q9UGU3|intact:EBI-1056800|uniprotkb:Q20WK5|ensembl:ENSP00000216129	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ttl12_human(display_long)|uniprotkb:TTLL12(gene name)|psi-mi:TTLL12(display_short)|uniprotkb:KIAA0153(gene name synonym)|uniprotkb:Inactive tubulin--tyrosine ligase-like protein 12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055955.1|ensembl:ENSG00000100304(gene)|ensembl:ENST00000216129(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015631"(tubulin binding)|go:"GO:0030496"(midbody)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0045087"(innate immune response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:1990889"(H4K20me3 modified histone binding)|interpro:IPR004344(Tubulin-tyrosine ligase)|interpro:IPR027749|reactome:R-HSA-8955332	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MXpuEK/k1S+fNxRGLpFGTO2YH2g9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51148	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51532	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302489|uniprotkb:O95052|uniprotkb:Q9HBD3|uniprotkb:B1A8Z4|uniprotkb:B1A8Z5|uniprotkb:B1A8Z6|uniprotkb:B1A8Z7|uniprotkb:E9PBR8|ensembl:ENSP00000343896|ensembl:ENSP00000395654	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smca4_human(display_long)|uniprotkb:SMARCA4(gene name)|psi-mi:SMARCA4(display_short)|uniprotkb:BRG1(gene name synonym)|uniprotkb:SNF2B(gene name synonym)|uniprotkb:SNF2L4(gene name synonym)|uniprotkb:ATP-dependent helicase SMARCA4(gene name synonym)|uniprotkb:SNF2-beta(gene name synonym)|uniprotkb:BAF190A(gene name synonym)|uniprotkb:Mitotic growth and transcription activator(gene name synonym)|uniprotkb:Protein BRG-1(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4(gene name synonym)|uniprotkb:Protein brahma homolog 1(gene name synonym)|uniprotkb:BRG1-associated factor 190A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001122316.1|refseq:NP_003063.2|refseq:NP_001122317.1|refseq:NP_001122318.1|refseq:NP_001122319.1|refseq:NP_001122320.1|dip:DIP-24249N|refseq:XP_016882654.1|refseq:XP_016882655.1|refseq:XP_016882656.1|refseq:XP_016882657.1|ensembl:ENSG00000127616(gene)|ensembl:ENST00000344626(transcript)|ensembl:ENST00000429416(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0002039"(p53 binding)|go:"GO:0003407"(neural retina development)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030100|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51532|rcsb pdb:2GRC|rcsb pdb:2H60|rcsb pdb:3UVD|rcsb pdb:5DKD|rcsb pdb:5EA1|rcsb pdb:6BGH|rcsb pdb:6HR2|rcsb pdb:6LTH|rcsb pdb:6LTJ|rcsb pdb:6SY2|rcsb pdb:6ZS2|reactome:R-HSA-1266695|reactome:R-HSA-201722|reactome:R-HSA-3214858|reactome:R-HSA-3247509|reactome:R-HSA-8939243|reactome:R-HSA-9619665	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ztr+2IXfAxueSUaNYG2A47HoMes9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46783	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354442|uniprotkb:Q5TZC0|uniprotkb:B2R4E3|ensembl:ENSP00000481646|ensembl:ENSP00000494190|ensembl:ENSP00000494440|ensembl:ENSP00000497917	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs10_human(display_long)|uniprotkb:RPS10(gene name)|psi-mi:RPS10(display_short)|uniprotkb:Small ribosomal subunit protein eS10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001005.1|refseq:NP_001190174.1|refseq:NP_001191020.1|ensembl:ENSG00000124614(gene)|ensembl:ENST00000464218(transcript)|ensembl:ENST00000467531(transcript)|ensembl:ENST00000621356(transcript)|ensembl:ENST00000648437(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR005326(Plectin/S10, N-terminal)|rcsb pdb:6G51|interpro:IPR036388|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|interpro:IPR037447|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|mint:P46783|rcsb pdb:4UG0|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:4V6X|rcsb pdb:6ZUO|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|rcsb pdb:5T2C|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GWUAJh7s0w/ar/SOpx0hiIJOr2c9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04843	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05556	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H583	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048716|uniprotkb:Q5T3Q8|uniprotkb:Q6P197|uniprotkb:Q9NW23|ensembl:ENSP00000355541	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:heat1_human(display_long)|uniprotkb:Protein BAP28(gene name synonym)|uniprotkb:HEATR1(gene name)|psi-mi:HEATR1(display_short)|uniprotkb:BAP28(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein 10 homolog(gene name synonym)|uniprotkb:UTP10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060542.4|ensembl:ENSG00000119285(gene)|ensembl:ENST00000366582(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034455"(t-UTP complex)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012954(BP28, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022125|interpro:IPR040191|mint:Q9H583|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:0WoP84UUVfXWppmvCYa/n5GTzc89606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62854	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353438|uniprotkb:P02383|uniprotkb:Q3MHD8|uniprotkb:P70394|uniprotkb:Q06722|uniprotkb:Q6IRY4|ensembl:ENSP00000348849|ensembl:ENSP00000450339|ensembl:ENSP00000496643	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs26_human(display_long)|uniprotkb:RPS26(gene name)|psi-mi:RPS26(display_short)|uniprotkb:Small ribosomal subunit protein eS26(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001020.2|refseq:XP_005276741.1|rcsb pdb:6OLG|rcsb pdb:6OLF|ensembl:ENST00000356464(transcript)|ensembl:ENST00000552361(transcript)|ensembl:ENST00000646449(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR000892(Ribosomal protein S26e)|interpro:IPR038551|mint:P62854|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6G5H|ensembl:ENSG00000197728(gene)|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-156827	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bo2ruYMNjjLCMo/kwAWzmlJrrjU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UHV9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62917	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-438527|ensembl:ENSP00000262584|ensembl:ENSP00000378378|ensembl:ENSP00000433464|uniprotkb:P25120|uniprotkb:Q567Q7|uniprotkb:Q969V7|uniprotkb:Q9BWQ9|uniprotkb:A8K094|uniprotkb:D3DWN2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl8_human(display_long)|uniprotkb:RPL8(gene name)|psi-mi:RPL8(display_short)|uniprotkb:Large ribosomal subunit protein uL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4CCN|rcsb pdb:4CCO|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4Y3O|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000161016(gene)|ensembl:ENST00000262584(transcript)|ensembl:ENST00000394920(transcript)|ensembl:ENST00000528957(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0098794"(postsynapse)|interpro:IPR002171(Ribosomal protein L2)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR014726(Ribosomal protein L2, domain 3)|interpro:IPR022666|interpro:IPR022669|interpro:IPR022671|interpro:IPR023672|mint:P62917|rcsb pdb:4CCM|refseq:NP_000964.1|refseq:NP_150644.1|refseq:NP_001304700.1|refseq:NP_001304711.1|dip:DIP-37967N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+b/ORzdCy/nqFLsKRV9VhIZgdjg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22102	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356297|ensembl:ENSP00000371236|ensembl:ENSP00000371253|ensembl:ENSP00000371261|ensembl:ENSP00000459391|ensembl:ENSP00000459532|ensembl:ENSP00000461700|uniprotkb:D3DSF3|uniprotkb:D3DSF4|uniprotkb:O14659|uniprotkb:A8KA32|uniprotkb:A8K945|uniprotkb:Q52M77	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pur2_human(display_long)|uniprotkb:GART(gene name)|psi-mi:GART(display_short)|uniprotkb:PRGS(gene name synonym)|uniprotkb:PGFT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0046084"(adenine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000115(Phosphoribosylglycinamide synthetase)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR004607(Phosphoribosylglycinamide formyltransferase)|interpro:IPR004733(Phosphoribosylformylglycinamidine cyclo-ligase)|interpro:IPR010918(AIR synthase related protein, C-terminal)|ensembl:ENST00000571089(transcript)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|ensembl:ENST00000573055(transcript)|ensembl:ENST00000575273(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0004637"(phosphoribosylamine-glycine ligase activity)|go:"GO:0004641"(phosphoribosylformylglycinamidine cyclo-ligase activity)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|go:"GO:0004644"(phosphoribosylglycinamide formyltransferase activity)|interpro:IPR016185(PreATP-grasp-like fold)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR016188(PurM, N-terminal-like)|ensembl:ENSG00000159131(gene)|ensembl:ENSG00000262473(gene)|ensembl:ENST00000381815(transcript)|ensembl:ENST00000381831(transcript)|ensembl:ENST00000381839(transcript)|interpro:IPR020560|interpro:IPR020561|interpro:IPR020562|interpro:IPR036477|interpro:IPR036676|interpro:IPR036921|interpro:IPR037123|mint:P22102|rcsb pdb:1MEJ|rcsb pdb:1MEN|rcsb pdb:1MEO|rcsb pdb:1NJS|rcsb pdb:1RBM|rcsb pdb:1RBQ|rcsb pdb:1RBY|rcsb pdb:1RBZ|rcsb pdb:1RC0|rcsb pdb:1RC1|rcsb pdb:1ZLX|rcsb pdb:1ZLY|rcsb pdb:2QK4|rcsb pdb:2V9Y|rcsb pdb:4EW1|rcsb pdb:4EW2|rcsb pdb:4EW3|rcsb pdb:4ZYT|interpro:IPR020559|rcsb pdb:4ZYU|rcsb pdb:4ZYV|rcsb pdb:4ZYW|rcsb pdb:4ZYX|rcsb pdb:4ZYY|rcsb pdb:4ZYZ|rcsb pdb:4ZZ0|rcsb pdb:4ZZ1|rcsb pdb:4ZZ2|rcsb pdb:5J9F|rcsb pdb:7JG0|rcsb pdb:4ZZ3|refseq:NP_000810.1|refseq:NP_001129477.1|refseq:NP_001129478.1|refseq:NP_780294.1|rcsb pdb:7JG4|reactome:R-HSA-73817|rcsb pdb:7JG3|refseq:XP_011527828.1|refseq:XP_006724052.1|refseq:XP_006724053.1|refseq:XP_005260998.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7Iy33CtBsB8LHZFDP5mZ3eRX8pU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BYB4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190293|ensembl:ENSP00000331313|ensembl:ENSP00000385154|uniprotkb:Q9H2S2|uniprotkb:Q9H4M4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gnb1l_human(display_long)|uniprotkb:GNB1L(gene name)|psi-mi:GNB1L(display_short)|uniprotkb:GY2(gene name synonym)|uniprotkb:KIAA1645(gene name synonym)|uniprotkb:WDR14(gene name synonym)|uniprotkb:DGCRK3(gene name synonym)|uniprotkb:WD repeat-containing protein 14(gene name synonym)|uniprotkb:WD40 repeat-containing protein deleted in VCFS(gene name synonym)|uniprotkb:FKSG1(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensembl:ENSG00000185838(gene)|ensembl:ENST00000329517(transcript)|ensembl:ENST00000403325(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_443730.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:txIUhYulfQGg1ly2Kgj27FNf+9U9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07339	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2115097|uniprotkb:Q6IB57|ensembl:ENSP00000236671	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:catd_human(display_long)|uniprotkb:CTSD(gene name)|psi-mi:CTSD(display_short)|uniprotkb:CPSD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001900.1|dip:DIP-43906N|ensembl:ENSG00000117984(gene)|ensembl:ENST00000236671(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033144|mint:P07339|rcsb pdb:1LYA|rcsb pdb:1LYB|rcsb pdb:1LYW|rcsb pdb:4OBZ|rcsb pdb:4OC6|rcsb pdb:4OD9|reactome:R-HSA-1442490|reactome:R-HSA-2022377|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-9018519	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M1qLQBlL2DSCZiAwIPee9Vza3dU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12829	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222789|uniprotkb:P11783|uniprotkb:D3DXJ7|ensembl:ENSP00000347055|ensembl:ENSP00000377096|ensembl:ENSP00000461570	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myl4_human(display_long)|uniprotkb:MYL4(gene name)|psi-mi:MYL4(display_short)|uniprotkb:MLC1(gene name synonym)|uniprotkb:PRO1957(orf name)|uniprotkb:Myosin light chain 1, embryonic muscle/atrial isoform(gene name synonym)|uniprotkb:Myosin light chain alkali GT-1 isoform(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002841.1|refseq:NP_002467.1|refseq:XP_005257448.1|ensembl:ENSG00000198336(gene)|ensembl:ENST00000354968(transcript)|ensembl:ENST00000393450(transcript)|ensembl:ENST00000572316(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0016459"(myosin complex)|go:"GO:0031672"(A band)|go:"GO:0032038"(myosin II heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|reactome:R-HSA-390522	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uoEY8vvAP2xDNz2TaBNrnxKFSGI9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04818	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190719|ensembl:ENSP00000315644|uniprotkb:Q8WYK3|uniprotkb:Q8WYK4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tysy_human(display_long)|uniprotkb:TYMS(gene name)|psi-mi:TYMS(display_short)|uniprotkb:TS(gene name synonym)|uniprotkb:OK/SW-cl.29(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000176890(gene)|ensembl:ENST00000323274(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0005542"(folic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0006235"(dTTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0019860"(uracil metabolic process)|go:"GO:0032259"(methylation)|go:"GO:0032570"(response to progesterone)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046683"(response to organophosphorus)|go:"GO:0048589"(developmental growth)|go:"GO:0051216"(cartilage development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051593"(response to folic acid)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|interpro:IPR023451|interpro:IPR036926|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019048"(modulation by virus of host process)|rcsb pdb:1HVY|rcsb pdb:4O1U|rcsb pdb:4O1X|rcsb pdb:4UP1|rcsb pdb:5HS3|rcsb pdb:5WRN|rcsb pdb:5X4W|rcsb pdb:5X4X|rcsb pdb:5X4Y|rcsb pdb:5X5A|rcsb pdb:4KPW|rcsb pdb:5X5D|rcsb pdb:5X5Q|rcsb pdb:5X66|rcsb pdb:5X67|rcsb pdb:5X69|rcsb pdb:6OJU|rcsb pdb:6OJV|rcsb pdb:6PF3|rcsb pdb:6PF4|rcsb pdb:6PF5|rcsb pdb:6PF6|rcsb pdb:6QXG|rcsb pdb:6QXH|rcsb pdb:6QYQ|rcsb pdb:6R2E|rcsb pdb:6ZXO|reactome:R-HSA-499943|reactome:R-HSA-69205|rcsb pdb:1HW4|rcsb pdb:1HZW|rcsb pdb:1I00|rcsb pdb:1JU6|rcsb pdb:1JUJ|rcsb pdb:1YPV|rcsb pdb:2ONB|rcsb pdb:2RD8|rcsb pdb:2RDA|rcsb pdb:3EAW|rcsb pdb:3EBU|rcsb pdb:3ED7|rcsb pdb:3EDW|rcsb pdb:3EF9|rcsb pdb:3EGY|rcsb pdb:3EHI|rcsb pdb:3EJL|rcsb pdb:3GG5|rcsb pdb:3GH0|rcsb pdb:3GH2|rcsb pdb:3H9K|rcsb pdb:3HB8|rcsb pdb:3N5E|rcsb pdb:3N5G|rcsb pdb:3OB7|rcsb pdb:4E28|rcsb pdb:4FGT|rcsb pdb:1HW3|rcsb pdb:4G2O|rcsb pdb:4G6W|rcsb pdb:4GD7|rcsb pdb:4GYH|rcsb pdb:4H1I|rcsb pdb:4JEF|go:"GO:0009636"(response to toxic substance)|go:"GO:0007568"(aging)|refseq:NP_001062.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9GWaP/MRO1tyHPXsZ+axd6j8lqM9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14974	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09429	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-389432|uniprotkb:Q6IBE1|uniprotkb:A5D8W9|uniprotkb:Q14321|uniprotkb:Q5T7C3|ensembl:ENSP00000343040|ensembl:ENSP00000345347|ensembl:ENSP00000382417|ensembl:ENSP00000384678	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmgb1_human(display_long)|uniprotkb:HMGB1(gene name)|psi-mi:HMGB1(display_short)|uniprotkb:HMG1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002119.1|refseq:NP_001300821.1|refseq:NP_001300822.1|ensembl:ENSG00000189403(gene)|ensembl:ENST00000339872(transcript)|ensembl:ENST00000341423(transcript)|ensembl:ENST00000399494(transcript)|ensembl:ENST00000405805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006265"(DNA topological change)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|interpro:IPR036910|mint:P09429|rcsb pdb:2LY4|rcsb pdb:2RTU|rcsb pdb:2YRQ|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|reactome:R-HSA-1236974|reactome:R-HSA-140342|reactome:R-HSA-166058|reactome:R-HSA-445989|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|dip:DIP-24195N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8iSPxYEMyB6thRmixTeyF5kfDbw9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07437	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54819	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08243	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722989|uniprotkb:P08184|uniprotkb:Q15666|uniprotkb:Q549T9|uniprotkb:Q96HD0|ensembl:ENSP00000175506|ensembl:ENSP00000377845|ensembl:ENSP00000377846|uniprotkb:A4D1I8|uniprotkb:D6W5R3|uniprotkb:B4DXZ1|uniprotkb:B7ZAA9|uniprotkb:E9PCI3|uniprotkb:E9PCX6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:asns_human(display_long)|uniprotkb:Glutamine-dependent asparagine synthetase(gene name synonym)|uniprotkb:Cell cycle control protein TS11(gene name synonym)|uniprotkb:ASNS(gene name)|psi-mi:ASNS(display_short)|uniprotkb:TS11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001171546.1|refseq:NP_001171547.1|refseq:NP_001171548.1|refseq:NP_001664.3|refseq:NP_597680.2|refseq:NP_899199.2|ensembl:ENSG00000070669(gene)|ensembl:ENST00000175506(transcript)|ensembl:ENST00000394308(transcript)|ensembl:ENST00000394309(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004066"("asparagine synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006529"(asparagine biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032354"(response to follicle-stimulating hormone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0070981"(L-asparagine biosynthetic process)|interpro:IPR001962(Asparagine synthase)|interpro:IPR006426(Asparagine synthase, glutamine-hydrolyzing)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017932|interpro:IPR029055|interpro:IPR033738|rcsb pdb:6GQ3|reactome:R-HSA-380994|reactome:R-HSA-8963693|reactome:R-HSA-9633012|reactome:R-HSA-9648895	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:McR8Ve0DzWhe3JWMYLsCRChiBaY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NU22	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050480|uniprotkb:O15019|uniprotkb:Q5T794|ensembl:ENSP00000358400|ensembl:ENSP00000486270|ensembl:ENSP00000499843|ensembl:ENSP00000499895	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mdn1_human(display_long)|uniprotkb:MIDAS-containing protein(gene name synonym)|uniprotkb:Dynein-related AAA-ATPase MDN1(gene name synonym)|uniprotkb:MDN1(gene name)|psi-mi:MDN1(display_short)|uniprotkb:KIAA0301(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055426.1|ensembl:ENSG00000112159(gene)|ensembl:ENSG00000288121(gene)|ensembl:ENST00000369393(transcript)|ensembl:ENST00000629399(transcript)|ensembl:ENST00000672983(transcript)|ensembl:ENST00000673332(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR012099(Midasin)|interpro:IPR027417|interpro:IPR036465|interpro:IPR040848|interpro:IPR041190|mint:Q9NU22|go:"GO:0005829"(cytosol)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/LVYhffZVpP0pYVM6hLNltoc6pY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y490	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14204	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46940	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43447	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92688	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09211	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353467|uniprotkb:O00460|uniprotkb:Q15690|ensembl:ENSP00000381607|uniprotkb:Q5TZY3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstp1_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short)|uniprotkb:GST3(gene name synonym)|uniprotkb:FAEES3(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:GSTP1-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000843.1|ensembl:ENSG00000084207(gene)|go:"GO:0000302"(response to reactive oxygen species)|ensembl:ENST00000398606(transcript)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0035732"(nitric oxide storage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P09211|rcsb pdb:10GS|rcsb pdb:11GS|rcsb pdb:12GS|rcsb pdb:13GS|rcsb pdb:14GS|rcsb pdb:16GS|rcsb pdb:17GS|rcsb pdb:18GS|rcsb pdb:19GS|rcsb pdb:1AQV|rcsb pdb:1AQW|rcsb pdb:1AQX|rcsb pdb:1EOG|rcsb pdb:1EOH|rcsb pdb:1GSS|rcsb pdb:1KBN|rcsb pdb:1LBK|rcsb pdb:1MD3|rcsb pdb:1MD4|rcsb pdb:1PGT|rcsb pdb:1PX6|rcsb pdb:1PX7|rcsb pdb:1ZGN|rcsb pdb:20GS|rcsb pdb:22GS|rcsb pdb:2A2R|rcsb pdb:2A2S|rcsb pdb:2GSS|rcsb pdb:2J9H|rcsb pdb:2PGT|rcsb pdb:3CSH|rcsb pdb:3CSI|rcsb pdb:3CSJ|rcsb pdb:3DD3|rcsb pdb:3DGQ|rcsb pdb:3GSS|rcsb pdb:3GUS|rcsb pdb:3HJM|rcsb pdb:3HJO|rcsb pdb:3HKR|rcsb pdb:3IE3|rcsb pdb:3KM6|rcsb pdb:3KMN|rcsb pdb:3KMO|rcsb pdb:3N9J|rcsb pdb:3PGT|rcsb pdb:4GSS|rcsb pdb:4PGT|rcsb pdb:5DAK|rcsb pdb:5DAL|rcsb pdb:5DCG|rcsb pdb:5DDL|rcsb pdb:5DJL|rcsb pdb:5DJM|rcsb pdb:5GSS|rcsb pdb:5J41|rcsb pdb:5JCW|rcsb pdb:5L6X|rcsb pdb:5X79|rcsb pdb:6AP9|rcsb pdb:6GSS|rcsb pdb:6LLX|rcsb pdb:6Y1E|rcsb pdb:7GSS|rcsb pdb:8GSS|rcsb pdb:9GSS|reactome:R-HSA-156590|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxqbNusNIvkTg3Cq+7pmygP/EIA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62241	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351811|uniprotkb:Q6IRL7|uniprotkb:P09058|ensembl:ENSP00000379888	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs8_human(display_long)|uniprotkb:RPS8(gene name)|psi-mi:RPS8(display_short)|uniprotkb:Small ribosomal subunit protein eS8(gene name synonym)|uniprotkb:OK/SW-cl.83(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001003.1|ensembl:ENSG00000142937(gene)|ensembl:ENST00000396651(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001047(Ribosomal protein S8e)|interpro:IPR018283|interpro:IPR022309|interpro:IPR042563|mint:P62241|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:6G5H|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975957|reactome:R-HSA-975956	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3rpCBdQyRWR+TCKnupbnCp30jKE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13645	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-465144|ensembl:ENSP00000269576|uniprotkb:Q14664|uniprotkb:Q8N175	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c10_human(display_long)|uniprotkb:KRT10(gene name)|psi-mi:KRT10(display_short)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:KPP(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000186395(gene)|ensembl:ENST00000269576(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P13645|rcsb pdb:3ASW|rcsb pdb:4F1Z|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6EC0|rcsb pdb:6UUI|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000412.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:z100yyq3b63P0ARy2lE2ELyJeik9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BQ69	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5324932|ensembl:ENSP00000255681|uniprotkb:Q9UH96	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:macd1_human(display_long)|uniprotkb:MACROD1(gene name)|psi-mi:MACROD1(display_short)|uniprotkb:LRP16(gene name synonym)|uniprotkb:Protein LRP16(gene name synonym)|uniprotkb:MACRO domain-containing protein 1(gene name synonym)|uniprotkb:O-acetyl-ADP-ribose deacetylase MACROD1(gene name synonym)|uniprotkb:[Protein ADP-ribosylaspartate] hydrolase MACROD1(gene name synonym)|uniprotkb:[Protein ADP-ribosylglutamate] hydrolase MACROD1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000133315(gene)|ensembl:ENST00000255681(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0019213"(deacetylase activity)|go:"GO:0042278"(purine nucleoside metabolic process)|go:"GO:0051725"(protein de-ADP-ribosylation)|go:"GO:0140291"(peptidyl-glutamate ADP-deribosylation)|go:"GO:0140293"(ADP-ribosylglutamate hydrolase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR043472|rcsb pdb:2X47|rcsb pdb:6LH4|refseq:NP_054786.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7gwLLBJKnqqdb89NYKEAtOdmMdU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q06830	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H0A0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UNQ2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-395738|uniprotkb:O76025|uniprotkb:Q9BU77|uniprotkb:Q9UES1|ensembl:ENSP00000199320	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dim1_human(display_long)|uniprotkb:DIMT1L(gene name synonym)|uniprotkb:DIM1 dimethyladenosine transferase 1 homolog(gene name synonym)|uniprotkb:DIM1 dimethyladenosine transferase 1-like(gene name synonym)|uniprotkb:HUSSY-05(orf name)|uniprotkb:"Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase"(gene name synonym)|uniprotkb:Probable 18S rRNA dimethylase(gene name synonym)|uniprotkb:DIMT1(gene name)|psi-mi:DIMT1(display_short)|uniprotkb:"Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055288.1|ensembl:ENSG00000086189(gene)|ensembl:ENST00000199320(transcript)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0031167"(rRNA methylation)|go:"GO:0052909"("18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity")|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR029063|mint:Q9UNQ2|rcsb pdb:1ZQ9|rcsb pdb:6W6C|rcsb pdb:6W6F|reactome:R-HSA-6790901|refseq:NP_001335005.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hx0FRrx+XTeoziOqfesiw4KL+wo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25788	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348380|ensembl:ENSP00000216455|uniprotkb:Q86U83|uniprotkb:Q8N1D8|uniprotkb:Q9BS70|uniprotkb:B2RCK6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa3_human(display_long)|uniprotkb:PSMA3(gene name)|psi-mi:PSMA3(display_short)|uniprotkb:PSC8(gene name synonym)|uniprotkb:Proteasome component C8(gene name synonym)|uniprotkb:Macropain subunit C8(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C8(gene name synonym)|uniprotkb:HC8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002779.1|refseq:NP_687033.1|ensembl:ENSG00000100567(gene)|ensembl:ENST00000216455(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR037555|mint:P25788|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:5DSV|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|rcsb pdb:7E55|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:5T0H|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-174084|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-174113|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|dip:DIP-29366N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9Er/PY50/GVoCr5yAPXlkfxtP0k9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09668	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6189940|ensembl:ENSP00000220166|uniprotkb:B2RBK0|uniprotkb:Q96NY6|uniprotkb:Q9BUM7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cath_human(display_long)|uniprotkb:CTSH(gene name)|psi-mi:CTSH(display_short)|uniprotkb:CPSB(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000103811(gene)|ensembl:ENST00000220166(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002764"(immune response-regulating signaling pathway)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060448"(dichotomous subdivision of terminal units involved in lung branching)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0097486"(multivesicular body lumen)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010813"(neuropeptide catabolic process)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030108"(HLA-A specific activating MHC class I receptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031638"(zymogen activation)|go:"GO:0031648"(protein destabilization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0005764"(lysosome)|interpro:IPR039417|rcsb pdb:1BZN|rcsb pdb:6CZK|rcsb pdb:6CZS|reactome:R-HSA-2132295|reactome:R-HSA-5683826|reactome:R-HSA-6798695|interpro:IPR038765|refseq:NP_004381.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tY1fBEZEkMs5w45HHaK5LVO574Q9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49411	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359097|uniprotkb:O15276|ensembl:ENSP00000322439	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eftu_human(display_long)|uniprotkb:TUFM(gene name)|psi-mi:TUFM(display_short)|uniprotkb:P43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003312.3|ensembl:ENSG00000178952(gene)|ensembl:ENST00000313511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004541(Translation elongation factor EFTu/EF1A, bacterial and organelle)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|interpro:IPR033720|interpro:IPR041709|mint:P49411|rcsb pdb:7A5G|rcsb pdb:7O9K|reactome:R-HSA-5389840|refseq:XP_016879108.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pDRPUBUqvFqnh613N8bDTl4sFHc9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36404	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-752365|uniprotkb:Q9BUK8|uniprotkb:G3V184|ensembl:ENSP00000246747|ensembl:ENSP00000436021	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arl2_human(display_long)|uniprotkb:ARL2(gene name)|psi-mi:ARL2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186674.1|refseq:NP_001658.2|dip:DIP-47535N|ensembl:ENSG00000213465(gene)|ensembl:ENST00000246747(transcript)|ensembl:ENST00000529384(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:P36404|rcsb pdb:3DOE|rcsb pdb:3DOF|reactome:R-HSA-389977|reactome:R-HSA-83936|reactome:R-HSA-9648002	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ArQxx65a8vITU2O0Kr0Qo0hqiqU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26038	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-528768|ensembl:ENSP00000353408	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14618	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92616	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356221|ensembl:ENSP00000300648|uniprotkb:O95001|uniprotkb:O95651|uniprotkb:Q6P2S3|uniprotkb:Q86X65|uniprotkb:Q8N5I5|uniprotkb:Q8WU80|uniprotkb:Q99736|uniprotkb:Q9UE60|uniprotkb:A8KAY1|intact:EBI-1058692	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gcn1_human(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)|uniprotkb:GCN1-like protein 1(gene name synonym)|uniprotkb:GCN1L1(gene name synonym)|uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)|uniprotkb:KIAA0219(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000089154(gene)|ensembl:ENST00000300648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085|mint:Q92616|reactome:R-HSA-9633012|go:"GO:0005844"(polysome)|refseq:NP_006827.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NtSEW6xjvCkUyb40cnk0JdL5PcA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50914	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356746|uniprotkb:Q45RF0|uniprotkb:Q53G20|uniprotkb:Q8TBD5|uniprotkb:Q8WUT0|uniprotkb:Q92579|uniprotkb:Q96GR0|uniprotkb:Q9BSB8|uniprotkb:Q9BW65|uniprotkb:Q9BYF6|ensembl:ENSP00000345156|ensembl:ENSP00000379506	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl14_human(display_long)|uniprotkb:RPL14(gene name)|psi-mi:RPL14(display_short)|uniprotkb:CAG-ISL 7(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL14(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001030168.1|refseq:NP_003964.3|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002784(Ribosomal protein L14)|interpro:IPR008991(Translation protein SH3-like)|ensembl:ENSG00000188846(gene)|ensembl:ENST00000338970(transcript)|ensembl:ENST00000396203(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041985|mint:P50914|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|interpro:IPR039660|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y2L	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AjaguD5hgHtcBbJq5QfuG6XdTcE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50897	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55884	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62333	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357669|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q6IBU3|uniprotkb:B2R975|ensembl:ENSP00000401802	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prs10_human(display_long)|uniprotkb:PSMC6(gene name)|psi-mi:PSMC6(display_short)|uniprotkb:SUG2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002797.3|ensembl:ENST00000445930(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000100519(gene)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62333|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-75815|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-174184|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|dip:DIP-38150N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QE8jzSEp1bpzhOi/oAAnV18QK249606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75608	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052185|uniprotkb:O43202|uniprotkb:Q9UQF9|ensembl:ENSP00000320043	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lypa1_human(display_long)|uniprotkb:Lysophospholipase 1(gene name synonym)|uniprotkb:Lysophospholipase I(gene name synonym)|uniprotkb:LYPLA1(gene name)|psi-mi:LYPLA1(display_short)|uniprotkb:APT1(gene name synonym)|uniprotkb:LPL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006321.1|refseq:NP_001266285.1|refseq:NP_001266286.1|refseq:NP_001266287.1|refseq:NP_001266288.1|refseq:NP_001266289.1|ensembl:ENSG00000120992(gene)|ensembl:ENST00000316963(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0016298"(lipase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003140(Phospholipase/carboxylesterase)|interpro:IPR029058|rcsb pdb:1FJ2|rcsb pdb:5SYM|rcsb pdb:6QGN|go:"GO:0005737"(cytoplasm)|rcsb pdb:6QGO|rcsb pdb:6QGQ|rcsb pdb:6QGS|reactome:R-HSA-203615|reactome:R-HSA-9648002	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y/NsD5HcH2FjnwUrSCBzeevQU+s9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05783	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297888|uniprotkb:Q53G38|uniprotkb:Q5U0N8|uniprotkb:Q9BW26|ensembl:ENSP00000373487|ensembl:ENSP00000373489	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c18_human(display_long)|uniprotkb:KRT18(gene name)|psi-mi:KRT18(display_short)|uniprotkb:CYK18(gene name synonym)|uniprotkb:Keratin-18(gene name synonym)|uniprotkb:PIG46(orf name)|uniprotkb:Cytokeratin-18(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 46 protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007049"(cell cycle)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009750"(response to fructose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0072497"(mesenchymal stem cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1902488"(cholangiocyte apoptotic process)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR027695|interpro:IPR039008|mint:P05783|reactome:R-HSA-6805567|reactome:R-HSA-6809371|ensembl:ENSG00000111057(gene)|ensembl:ENST00000388835(transcript)|ensembl:ENST00000388837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|refseq:NP_000215.1|refseq:NP_954657.1|dip:DIP-633N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6rtLZxuG0CSGcsCHEmkRKFVDeyo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30041	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2255129|uniprotkb:A8JZY7|uniprotkb:P32077|uniprotkb:Q5TAH4|uniprotkb:Q5ZEZ8|ensembl:ENSP00000342026	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx6_human(display_long)|uniprotkb:PRDX6(gene name)|psi-mi:PRDX6(display_short)|uniprotkb:AOP2(gene name synonym)|uniprotkb:KIAA0106(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:24 kDa protein(gene name synonym)|uniprotkb:Liver 2D page spot 40(gene name synonym)|uniprotkb:Red blood cells page spot 12(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004896.1|ensembl:ENSG00000117592(gene)|ensembl:ENST00000340385(transcript)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:1PRX|rcsb pdb:5B6M|rcsb pdb:5B6N|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0042744"(hydrogen peroxide catabolic process)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZMsHgrAJf0VJiCELzo+zSi8Ji+49606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P258	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352547|uniprotkb:Q8IVL9|uniprotkb:Q9BSN6|uniprotkb:Q9NPV8|ensembl:ENSP00000364582|ensembl:ENSP00000364585|ensembl:ENSP00000486099|ensembl:ENSP00000486447	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rcc2_human(display_long)|uniprotkb:RCC2(gene name)|psi-mi:RCC2(display_short)|uniprotkb:KIAA1470(gene name synonym)|uniprotkb:TD60(gene name synonym)|uniprotkb:Telophase disk protein of 60 kDa(gene name synonym)|uniprotkb:RCC1-like protein TD-60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129676.1|refseq:NP_061185.1|ensembl:ENSG00000179051(gene)|ensembl:ENSG00000281540(gene)|ensembl:ENST00000375433(transcript)|ensembl:ENST00000375436(transcript)|ensembl:ENST00000628984(transcript)|ensembl:ENST00000631021(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR028641|mint:Q9P258|rcsb pdb:5GWN|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:z9+0avftBLs4Q3ODFHLEmJtd57A9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02786	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07737	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713780|ensembl:ENSP00000225655|uniprotkb:Q53Y44	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prof1_human(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:PFN1(gene name)|psi-mi:PFN1(display_short)|uniprotkb:Epididymis tissue protein Li 184a(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108518(gene)|ensembl:ENST00000225655(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P07737|rcsb pdb:1AWI|rcsb pdb:1CF0|rcsb pdb:1CJF|rcsb pdb:1FIK|rcsb pdb:1FIL|rcsb pdb:1PFL|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|rcsb pdb:4X1L|rcsb pdb:4X1M|rcsb pdb:4X25|rcsb pdb:6NAS|rcsb pdb:6NBE|rcsb pdb:6NBW|reactome:R-HSA-114608|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|reactome:R-HSA-4086400|reactome:R-HSA-5663220|reactome:R-HSA-376176|refseq:NP_005013.1|dip:DIP-30N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CncaC5RMylvzFLhqzpS+VbhQn6I9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13765	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712216|ensembl:ENSP00000349212|ensembl:ENSP00000377469|ensembl:ENSP00000446801|ensembl:ENSP00000447821|ensembl:ENSP00000503345|uniprotkb:Q3KQV4|uniprotkb:Q53A18|uniprotkb:Q53G46|uniprotkb:A8MTN7|uniprotkb:B2R4P8|uniprotkb:F8VU71	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:naca_human(display_long)|uniprotkb:Alpha-NAC(gene name synonym)|uniprotkb:NACA(gene name)|psi-mi:NACA(display_short)|uniprotkb:HSD48(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000196531(gene)|ensembl:ENST00000356769(transcript)|ensembl:ENST00000393891(transcript)|ensembl:ENST00000546392(transcript)|ensembl:ENST00000552540(transcript)|ensembl:ENST00000678066(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006412"(translation)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0015031"(protein transport)|go:"GO:0042060"(wound healing)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901227"(negative regulation of transcription from RNA polymerase II promoter involved in heart development)|go:"GO:1901228"(positive regulation of transcription from RNA polymerase II promoter involved in heart development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR016641(Nascent polypeptide-associated complex, alpha subunit)|interpro:IPR038187|interpro:IPR044034|mint:Q13765|rcsb pdb:3LKX|rcsb pdb:3MCB|rcsb pdb:3MCE|go:"GO:0043403"(skeletal muscle tissue regeneration)|refseq:NP_001106672.1|refseq:NP_001307122.1|refseq:NP_001307123.1|refseq:NP_005585.1|refseq:NP_001106673.1|refseq:NP_001106674.2|dip:DIP-43878N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l8QKB8mfSwvDDSSObGLQ7i1LgWo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36542	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35580	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40939	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13263	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11717	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15185	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07355	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28482	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-959949|ensembl:ENSP00000215832|ensembl:ENSP00000381803|uniprotkb:A8CZ64	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mk01_human(display_long)|uniprotkb:MAPK1(gene name)|psi-mi:MAPK1(display_short)|uniprotkb:ERK2(gene name synonym)|uniprotkb:PRKM1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)|uniprotkb:PRKM2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-112411|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-437239|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|refseq:NP_002736.3|refseq:NP_620407.1|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P28482|rcsb pdb:1PME|go:"GO:0072686"(mitotic spindle)|rcsb pdb:1TVO|rcsb pdb:1WZY|rcsb pdb:2OJG|rcsb pdb:2OJI|rcsb pdb:2OJJ|rcsb pdb:2Y9Q|rcsb pdb:3D42|rcsb pdb:3D44|rcsb pdb:3I5Z|rcsb pdb:3I60|rcsb pdb:3SA0|rcsb pdb:3TEI|rcsb pdb:3W55|rcsb pdb:4FMQ|rcsb pdb:4FUX|rcsb pdb:4FUY|rcsb pdb:4FV0|rcsb pdb:4FV1|rcsb pdb:4FV2|rcsb pdb:4FV3|rcsb pdb:4FV4|rcsb pdb:4FV5|rcsb pdb:4FV6|rcsb pdb:4FV7|rcsb pdb:4FV8|rcsb pdb:4FV9|rcsb pdb:4G6N|rcsb pdb:4G6O|rcsb pdb:4H3P|rcsb pdb:4H3Q|rcsb pdb:4IZ5|rcsb pdb:4IZ7|rcsb pdb:4IZA|rcsb pdb:4N0S|rcsb pdb:4NIF|rcsb pdb:4O6E|rcsb pdb:4QP1|rcsb pdb:4QP2|rcsb pdb:4QP3|rcsb pdb:4QP4|rcsb pdb:4QP6|rcsb pdb:4QP7|rcsb pdb:4QP8|rcsb pdb:4QP9|rcsb pdb:4QPA|rcsb pdb:4QTA|rcsb pdb:4QTE|rcsb pdb:4XJ0|rcsb pdb:4ZXT|rcsb pdb:4ZZM|rcsb pdb:4ZZN|rcsb pdb:4ZZO|rcsb pdb:5AX3|rcsb pdb:5BUE|rcsb pdb:5BUI|rcsb pdb:5BUJ|rcsb pdb:5BVD|rcsb pdb:5BVE|rcsb pdb:5BVF|rcsb pdb:5K4I|rcsb pdb:5LCJ|rcsb pdb:5LCK|rcsb pdb:5NGU|rcsb pdb:5NHF|rcsb pdb:5NHH|rcsb pdb:5NHJ|rcsb pdb:5NHL|rcsb pdb:5NHO|rcsb pdb:5NHP|rcsb pdb:5NHV|rcsb pdb:5V60|rcsb pdb:5V61|rcsb pdb:5V62|rcsb pdb:5WP1|rcsb pdb:6D5Y|rcsb pdb:6DMG|rcsb pdb:6G54|rcsb pdb:6G8X|rcsb pdb:6G91|rcsb pdb:6G92|rcsb pdb:6G93|rcsb pdb:6G97|rcsb pdb:6G9A|rcsb pdb:6G9D|rcsb pdb:6G9H|rcsb pdb:6G9J|rcsb pdb:6G9K|rcsb pdb:6G9M|rcsb pdb:6G9N|rcsb pdb:6GDM|rcsb pdb:6GDQ|rcsb pdb:6GE0|rcsb pdb:6GJB|rcsb pdb:6GJD|rcsb pdb:6NBS|rcsb pdb:6OPG|rcsb pdb:6OPH|rcsb pdb:6OPI|rcsb pdb:6Q7K|rcsb pdb:6Q7S|rcsb pdb:6Q7T|rcsb pdb:6QA1|rcsb pdb:6QA3|rcsb pdb:6QA4|rcsb pdb:6QAG|rcsb pdb:6QAH|rcsb pdb:6QAL|rcsb pdb:6QAQ|rcsb pdb:6QAW|rcsb pdb:6RQ4|rcsb pdb:6SLG|reactome:R-HSA-111995|reactome:R-HSA-112409|ensembl:ENSG00000100030(gene)|ensembl:ENST00000215832(transcript)|ensembl:ENST00000398822(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634635|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9652817|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|dip:DIP-519N|ensembl:ENSP00000215832|ensembl:ENSP00000381803|ensembl:ENST00000544786|ensembl:ENSP00000440842	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:odzhd70I/8uWedx0+gF38lhe60I9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13612	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52597	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352986|ensembl:ENSP00000338477|ensembl:ENSP00000349573|ensembl:ENSP00000400433|ensembl:ENSP00000438061|ensembl:ENSP00000507787|ensembl:ENSP00000348345|uniprotkb:Q5T0N2|uniprotkb:Q96AU2|uniprotkb:B3KM84	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpf_human(display_long)|uniprotkb:HNRNPF(gene name)|psi-mi:HNRNPF(display_short)|uniprotkb:HNRPF(gene name synonym)|uniprotkb:Nucleolin-like protein mcs94-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P52597|rcsb pdb:2HGL|rcsb pdb:2HGM|rcsb pdb:2HGN|rcsb pdb:2KFY|rcsb pdb:2KG0|rcsb pdb:2KG1|rcsb pdb:3TFY|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000169813(gene)|ensembl:ENST00000337970(transcript)|ensembl:ENST00000356053(transcript)|ensembl:ENST00000357065(transcript)|ensembl:ENST00000443950(transcript)|ensembl:ENST00000544000(transcript)|ensembl:ENST00000682386(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001091674.1|refseq:NP_001091675.1|refseq:NP_001091676.1|refseq:NP_001091677.1|refseq:NP_001091678.1|refseq:NP_004957.1|dip:DIP-33145N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pblzpldZOa5vlZ+zGQY9qyWCxaw9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51570	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2269932|uniprotkb:B2RC07|intact:EBI-6190170|uniprotkb:B4E1G6|ensembl:ENSP00000225614|ensembl:ENSP00000465930	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:galk1_human(display_long)|uniprotkb:GALK1(gene name)|psi-mi:GALK1(display_short)|uniprotkb:GALK(gene name synonym)|uniprotkb:Galactose kinase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0019388"(galactose catabolic process)|go:"GO:0019402"(galactitol metabolic process)|go:"GO:0061623"(glycolytic process from galactose)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000705(Galactokinase)|interpro:IPR006203(GHMP kinase, ATP-binding, conserved site)|interpro:IPR006204(GHMP kinase)|interpro:IPR006206(Mevalonate and galactokinase)|interpro:IPR013750(GHMP kinase, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR019539|interpro:IPR019741|interpro:IPR020568|interpro:IPR036554|mint:P51570|ensembl:ENSG00000108479(gene)|ensembl:ENST00000225614(transcript)|ensembl:ENST00000588479(transcript)|go:"GO:0004335"(galactokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005534"(galactose binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0016020"(membrane)|rcsb pdb:1WUU|rcsb pdb:1YH7|rcsb pdb:6GR2|rcsb pdb:6Q3W|rcsb pdb:6Q3X|rcsb pdb:6Q8Z|rcsb pdb:6Q90|rcsb pdb:6Q91|rcsb pdb:6QJE|rcsb pdb:6ZFH|rcsb pdb:6ZGV|rcsb pdb:6ZGW|rcsb pdb:6ZGX|rcsb pdb:6ZGY|rcsb pdb:6ZGZ|reactome:R-HSA-5609976|reactome:R-HSA-70370	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TtFcTQq+nspsst+xInA/huo/ZbU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62829	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353303|uniprotkb:P23131|uniprotkb:Q3SWV7|uniprotkb:P24048|uniprotkb:Q29246|uniprotkb:Q6P5S1|ensembl:ENSP00000377865|ensembl:ENSP00000420311	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl23_human(display_long)|uniprotkb:RPL23(gene name)|psi-mi:RPL23(display_short)|uniprotkb:60S ribosomal protein L17(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL14(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|reactome:R-HSA-9010553|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|refseq:NP_000969.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62829|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|ensembl:ENSG00000125691(gene)|ensembl:ENST00000394332(transcript)|ensembl:ENST00000479035(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005730"(nucleolus)|dip:DIP-33156N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60468	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63010	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14566	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30626	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750459|uniprotkb:D6W5Q0|intact:EBI-2623494|uniprotkb:A8MTH6|uniprotkb:B4DKK2|ensembl:ENSP00000265729	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sorcn_human(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_944490.1|refseq:NP_003121.1|refseq:NP_001243820.1|refseq:NP_001243821.1|dip:DIP-40970N|ensembl:ENSG00000075142(gene)|ensembl:ENST00000265729(transcript)|go:"GO:0001508"(action potential)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|rcsb pdb:2JC2|rcsb pdb:4U8D|rcsb pdb:4UPG|rcsb pdb:4USL|rcsb pdb:5MRA|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P30626|rcsb pdb:1JUO	-	-	crc64:A4829C7650A5E3FA	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:upE31IMimaotkgnYa7HYr7EYAxc9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14839-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190797|ensembl:ENSP00000496634	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q14839-2(display_long)|uniprotkb:CHD4(gene name)|psi-mi:CHD4(display_short)|uniprotkb:ATP-dependent helicase CHD4(gene name synonym)|uniprotkb:Mi-2 autoantigen 218 kDa protein(gene name synonym)|uniprotkb:Mi2-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	intact:EBI-372916(isoform-parent)|ensembl:ENSG00000111642(gene)|ensembl:ENST00000645095(transcript)|uniprotkb:Q14839-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Msvk6YtgmdEXu9Kvatu7Qghc4BM9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62195	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N	-	-	crc64:29C6410C4A85A7F7	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12270	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048528|uniprotkb:Q15655|uniprotkb:Q99968|uniprotkb:Q5SWY0|intact:EBI-2555905|uniprotkb:Q15624|intact:EBI-28974527|ensembl:ENSP00000356448	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tpr_human(display_long)|uniprotkb:TPR(gene name)|psi-mi:TPR(display_short)|uniprotkb:Megator(gene name synonym)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000356448|ensembl:ENST00000613151|ensembl:ENSP00000483425|refseq:NP_003283.2|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|rcsb pdb:5TO5|rcsb pdb:5TO6|rcsb pdb:5TO7|rcsb pdb:5TVB|reactome:R-HSA-1169408|reactome:R-HSA-159227|ensembl:ENSG00000047410(gene)|ensembl:ENST00000367478(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|dip:DIP-50405N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vgoHzJI4cSOfqPSDoy+E067AdoI9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75340	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352915|uniprotkb:E7ESR3|uniprotkb:Q5TZS0|uniprotkb:B2RD16|uniprotkb:Q2YDC2|ensembl:ENSP00000264933	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdcd6_human(display_long)|uniprotkb:PDCD6(gene name)|psi-mi:PDCD6(display_short)|uniprotkb:ALG2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O75340|rcsb pdb:2ZN8|rcsb pdb:2ZN9|rcsb pdb:2ZND|rcsb pdb:2ZNE|rcsb pdb:2ZRS|rcsb pdb:2ZRT|rcsb pdb:3AAJ|rcsb pdb:3AAK|rcsb pdb:3WXA|rcsb pdb:5GQQ|go:"GO:0046983"(protein dimerization activity)|refseq:NP_037364.1|refseq:NP_001254485.1|refseq:NP_001254486.1|refseq:NP_001254487.1|refseq:NP_001254488.1|ensembl:ENSG00000249915(gene)|ensembl:ENST00000264933(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|dip:DIP-33217N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qbNAx73X9TJNr0MVNcy7Q9qN3Hg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92522	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876335|ensembl:ENSP00000329662	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h1x_human(display_long)|uniprotkb:H1-10(gene name)|psi-mi:H1-10(display_short)|uniprotkb:H1FX(gene name synonym)|uniprotkb:Histone H1x(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000184897(gene)|ensembl:ENST00000333762(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045296"(cadherin binding)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:Q92522|refseq:NP_006017.1|dip:DIP-36358N|rcsb pdb:2LSO|rcsb pdb:6L9Z|rcsb pdb:7K60|rcsb pdb:7K63	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T+NweCoHXj0rYsS6gJ4V42R9MpA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43324	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048486|uniprotkb:Q5THS2|ensembl:ENSP00000369038|uniprotkb:C9JLK5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mca3_human(display_long)|uniprotkb:Multisynthase complex auxiliary component p18(gene name synonym)|uniprotkb:Elongation factor p18(gene name synonym)|uniprotkb:EEF1E1(gene name)|psi-mi:EEF1E1(display_short)|uniprotkb:P18(gene name synonym)|uniprotkb:AIMP3(gene name synonym)|uniprotkb:Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129122.1|refseq:NP_004271.1|ensembl:ENSG00000124802(gene)|ensembl:ENST00000379715(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036282|interpro:IPR042450|mint:O43324|rcsb pdb:2UZ8|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5BMU|rcsb pdb:5Y6L|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-50581N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4AuJouC9q6uAH/4EH8SKSPHyEZU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355710|uniprotkb:A8JZY8|ensembl:ENSP00000280326|uniprotkb:A8K2X8|uniprotkb:B4DYD8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpe_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)|uniprotkb:CCTE(gene name synonym)|uniprotkb:KIAA0098(gene name synonym)|uniprotkb:CCT-epsilon(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036205.1|ensembl:ENSG00000150753(gene)|ensembl:ENST00000280326(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|refseq:NP_001293084.1|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P48643|rcsb pdb:5UYX|rcsb pdb:5UYZ|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR012718(T-complex protein 1, epsilon subunit)|dip:DIP-31181N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u7uFkOYrDKL0gGvC24p34tQHhcw9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4DKZ6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190845	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4dkz6_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000347"(THO complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|interpro:IPR032302|interpro:IPR021418|interpro:IPR021726|interpro:IPR040007	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YylX+q+OBzcU2jw2I/I1tV+uRYU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05109	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355281|uniprotkb:Q5SY70|uniprotkb:Q9UC92|uniprotkb:Q9UCJ0|uniprotkb:A8K5L3|uniprotkb:Q9UC84|uniprotkb:Q9UCM6|uniprotkb:D3DV37|ensembl:ENSP00000357721|ensembl:ENSP00000357722	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:s10a8_human(display_long)|uniprotkb:S100A8(gene name)|psi-mi:S100A8(display_short)|uniprotkb:CAGA(gene name synonym)|uniprotkb:MRP8(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:S100 calcium-binding protein A8(gene name synonym)|uniprotkb:Calgranulin-A(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 8(gene name synonym)|uniprotkb:Cystic fibrosis antigen(gene name synonym)|uniprotkb:Leukocyte L1 complex light chain(gene name synonym)|uniprotkb:Calprotectin L1L subunit(gene name synonym)|uniprotkb:Urinary stone protein band A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001306126.1|refseq:NP_001306127.1|refseq:NP_001306130.1|refseq:NP_002955.2|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045471"(response to ethanol)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028474|go:"GO:0035662"(Toll-like receptor 4 binding)|mint:P05109|rcsb pdb:1MR8|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5HLO|rcsb pdb:5HLV|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENST00000368732(transcript)|ensembl:ENST00000368733(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|ensembl:ENSG00000143546(gene)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|dip:DIP-1165N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Okfhj8fxclZ0Uo/Fa1Z89qC8Ec9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04075	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BV40	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727028|uniprotkb:O60625|uniprotkb:Q53SP9|uniprotkb:Q6IB09|ensembl:ENSP00000263864	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vamp8_human(display_long)|uniprotkb:Endobrevin(gene name synonym)|uniprotkb:VAMP8(gene name)|psi-mi:VAMP8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003752.2|ensembl:ENSG00000118640(gene)|ensembl:ENST00000263864(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|mint:Q9BV40|rcsb pdb:4WY4|rcsb pdb:7BV6|reactome:R-HSA-1236974|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|dip:DIP-40358N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DW/t33n6NkBelQt6H1QS5hUY5+E9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35527	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356382|uniprotkb:O00109|uniprotkb:Q0IJ47|uniprotkb:Q14665|ensembl:ENSP00000246662	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c9_human(display_long)|uniprotkb:KRT9(gene name)|psi-mi:KRT9(display_short)|uniprotkb:Keratin-9(gene name synonym)|uniprotkb:Cytokeratin-9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000217.2|ensembl:ENSG00000171403(gene)|ensembl:ENST00000246662(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0043588"(skin development)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P35527|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m4EXfxbK2t1/EmI04YODKTJ02Zw9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A5YKK6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222758|uniprotkb:Q68DX7|uniprotkb:Q7Z3K2|uniprotkb:Q8IWB8|uniprotkb:Q8TB53|uniprotkb:Q9BVZ6|uniprotkb:Q9UFR8|uniprotkb:Q9UI27|uniprotkb:Q9Y2L0|intact:EBI-2561986|ensembl:ENSP00000320949	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cnot1_human(display_long)|uniprotkb:CNOT1(gene name)|psi-mi:CNOT1(display_short)|uniprotkb:CDC39(gene name synonym)|uniprotkb:KIAA1007(gene name synonym)|uniprotkb:NOT1(gene name synonym)|uniprotkb:Negative regulator of transcription subunit 1 homolog(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:AD-005(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057368.3|refseq:NP_996882.1|refseq:NP_001252541.1|dip:DIP-44954N|ensembl:ENSG00000125107(gene)|ensembl:ENST00000317147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|mint:A5YKK6|rcsb pdb:4C0D|rcsb pdb:4CQO|rcsb pdb:4CRU|rcsb pdb:4CRV|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT6|rcsb pdb:4CT7|rcsb pdb:4GMJ|rcsb pdb:4GML|rcsb pdb:4J8S|rcsb pdb:5ANR|rcsb pdb:5FU6|rcsb pdb:5FU7|rcsb pdb:5ONA|reactome:R-HSA-429947|reactome:R-HSA-6804115	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qYUeacTR9wuDH02Uy8CqCcaaXOY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43143	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237044|uniprotkb:Q9NQT7|ensembl:ENSP00000336741	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx15_human(display_long)|uniprotkb:DHX15(gene name)|psi-mi:DHX15(display_short)|uniprotkb:DBP1(gene name synonym)|uniprotkb:DDX15(gene name synonym)|uniprotkb:DEAH box protein 15(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001349.2|dip:DIP-38211N|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR044756|mint:O43143|rcsb pdb:5XDR|rcsb pdb:6ID1|rcsb pdb:6SH6|rcsb pdb:6SH7|reactome:R-HSA-72163|ensembl:ENSG00000109606(gene)|ensembl:ENST00000336812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0043279"(response to alkaloid)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rOkQ5RG/3gc1/0Qcn5ANS6ImepY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350581|uniprotkb:B2R4B3|ensembl:ENSP00000346015	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl27a_human(display_long)|uniprotkb:RPL27A(gene name)|psi-mi:RPL27A(display_short)|uniprotkb:Large ribosomal subunit protein uL15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000981.1|ensembl:ENSG00000166441(gene)|ensembl:ENST00000314138(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001196(Ribosomal protein L15)|interpro:IPR021131|interpro:IPR027386|interpro:IPR030878|interpro:IPR036227|mint:P46776|rcsb pdb:4BXF|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6IP6|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6OM7|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:6IP5|dip:DIP-33121N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tUezMQBw+SWmLYq8M0pkLCF8vO89606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40926	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95372	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715999|uniprotkb:Q7Z4Z2|ensembl:ENSP00000363638	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lypa2_human(display_long)|uniprotkb:Lysophospholipase II(gene name synonym)|uniprotkb:LYPLA2(gene name)|psi-mi:LYPLA2(display_short)|uniprotkb:APT2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009191.1|ensembl:ENSG00000011009(gene)|ensembl:ENST00000374514(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007411"(axon guidance)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0045296"(cadherin binding)|go:"GO:0046464"(acylglycerol catabolic process)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905344"(prostaglandin catabolic process)|interpro:IPR003140(Phospholipase/carboxylesterase)|interpro:IPR029058|rcsb pdb:5SYN|rcsb pdb:6BJE|reactome:R-HSA-373760	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yJ0IGnOIc6UvuzuLdZb8WzlN9aY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62140	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61981	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28066	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355475|uniprotkb:B4E2V4|uniprotkb:Q6IBF7|uniprotkb:Q3T1C1|uniprotkb:B2R8F6|ensembl:ENSP00000271308	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa5_human(display_long)|uniprotkb:PSMA5(gene name)|psi-mi:PSMA5(display_short)|uniprotkb:Proteasome zeta chain(gene name synonym)|uniprotkb:Macropain zeta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex zeta chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186701.1|refseq:NP_001186702.1|refseq:NP_001186703.1|refseq:NP_002781.2|ensembl:ENSG00000143106(gene)|ensembl:ENST00000271308(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR033812|mint:P28066|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEY|rcsb pdb:5LEX|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29368N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfMG3npzVetUH1tahr2MAI4R+3g9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4DX78	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4dx78_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:w8STRlDtOptPq7bILJWhcRV5g5E9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10768	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052334|uniprotkb:Q5TBU8|uniprotkb:Q5TBV0|uniprotkb:Q5TBV2|uniprotkb:Q9BVJ2|ensembl:ENSP00000367992	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:estd_human(display_long)|uniprotkb:Esterase D(gene name synonym)|uniprotkb:ESD(gene name)|psi-mi:ESD(display_short)|uniprotkb:Methylumbelliferyl-acetate deacetylase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001975.1|refseq:XP_011533256.1|refseq:XP_005266335.1|ensembl:ENSG00000139684(gene)|ensembl:ENST00000378720(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0018738"(S-formylglutathione hydrolase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0046294"(formaldehyde catabolic process)|go:"GO:0047374"(methylumbelliferyl-acetate deacetylase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000801(Putative esterase)|interpro:IPR014186(S-formylglutathione hydrolase)|interpro:IPR029058|rcsb pdb:3FCX|reactome:R-HSA-156590	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I8V/PLKeeDbsSgkLk0BADWVbDdg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31948	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P16401	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5327611|uniprotkb:Q14529|uniprotkb:Q3MJ42|ensembl:ENSP00000330074	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h15_human(display_long)|uniprotkb:H1-5(gene name)|psi-mi:H1-5(display_short)|uniprotkb:H1F5(gene name synonym)|uniprotkb:HIST1H1B(gene name synonym)|uniprotkb:Histone H1a(gene name synonym)|uniprotkb:Histone H1b(gene name synonym)|uniprotkb:Histone H1s-3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005313.1|ensembl:ENSG00000184357(gene)|ensembl:ENST00000331442(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0071169"(establishment of protein localization to chromatin)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2FE2|rcsb pdb:2RHI|reactome:R-HSA-140342|reactome:R-HSA-2559584|go:"GO:0000792"(heterochromatin)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:b81Z7VA09Na0XXDfR0HtaZmq1g89606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UPN3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-522925|uniprotkb:E9PJT0|uniprotkb:O75053|uniprotkb:Q5VW20|uniprotkb:Q8WXY2|uniprotkb:Q9H540|uniprotkb:Q9UKP0|uniprotkb:Q9ULG9|intact:EBI-28967632|uniprotkb:B1ALC5|uniprotkb:Q8WXY1|uniprotkb:Q96PK2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:macf1_human(display_long)|uniprotkb:Actin cross-linking family protein 7(gene name synonym)|uniprotkb:Macrophin-1(gene name synonym)|uniprotkb:Trabeculin-alpha(gene name synonym)|uniprotkb:620 kDa actin-binding protein(gene name synonym)|uniprotkb:MACF1(gene name)|psi-mi:MACF1(display_short)|uniprotkb:ABP620(gene name synonym)|uniprotkb:ACF7(gene name synonym)|uniprotkb:KIAA0465(gene name synonym)|uniprotkb:KIAA1251(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000361689|ensembl:ENSP00000354573|ensembl:ENSG00000127603|refseq:NP_036222.3|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0150011"(regulation of neuron projection arborization)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR011992(EF-Hand type)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|rcsb pdb:4Z6G|rcsb pdb:5VE9|rcsb pdb:5X57|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|dip:DIP-50616N|mint:Q9UPN3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G5PesqPZZxQhwDgW0pBJSkJNcZ49606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04264	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-298429|uniprotkb:Q14720|uniprotkb:Q6GSJ0|uniprotkb:B2RA01|uniprotkb:Q9H298|ensembl:ENSP00000252244|uniprotkb:P85925|uniprotkb:P86104	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c1_human(display_long)|uniprotkb:KRT1(gene name)|psi-mi:KRT1(display_short)|uniprotkb:KRTA(gene name synonym)|uniprotkb:Keratin-1(gene name synonym)|uniprotkb:Cytokeratin-1(gene name synonym)|uniprotkb:67 kDa cytokeratin(gene name synonym)|uniprotkb:Hair alpha protein(gene name synonym)|uniprotkb:Type-II keratin Kb1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006112.3|ensembl:ENSG00000167768(gene)|ensembl:ENST00000252244(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045095"(keratin filament)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR032449|interpro:IPR039008|mint:P04264|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6UUI|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TeAC3i2hWTS2lgXT0i4agp9nv349606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07741	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047565|uniprotkb:Q3KP55|uniprotkb:G5E9J2|uniprotkb:Q68DF9|ensembl:ENSP00000367615	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:apt_human(display_long)|uniprotkb:APRT(gene name)|psi-mi:APRT(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000476.1|ensembl:ENSG00000198931(gene)|ensembl:ENST00000378364(transcript)|go:"GO:0002055"(adenine binding)|go:"GO:0003999"(adenine phosphoribosyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006168"(adenine salvage)|go:"GO:0007595"(lactation)|go:"GO:0007625"(grooming behavior)|go:"GO:0016208"(AMP binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0044209"(AMP salvage)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005764(Adenine phosphoribosyl transferase)|interpro:IPR029057|rcsb pdb:1OPU|rcsb pdb:1ORE|rcsb pdb:1ZN7|rcsb pdb:1ZN8|rcsb pdb:1ZN9|rcsb pdb:4X44|rcsb pdb:4X45|rcsb pdb:6FCH|rcsb pdb:6FCI|rcsb pdb:6FCL|rcsb pdb:6FD4|rcsb pdb:6FD5|rcsb pdb:6FD6|rcsb pdb:6HGP|rcsb pdb:6HGQ|rcsb pdb:6HGR|rcsb pdb:6HGS|reactome:R-HSA-6798695|reactome:R-HSA-74217|refseq:NP_001025189.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x046RPUzHysaN5PWMM0UCSyt9xI9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UKD2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1046493|ensembl:ENSP00000364320|uniprotkb:Q9BPV9|uniprotkb:Q5TG55|uniprotkb:Q96SS6|uniprotkb:B3KNB3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mrt4_human(display_long)|uniprotkb:MRTO4(gene name)|psi-mi:MRTO4(display_short)|uniprotkb:C1orf33(gene name synonym)|uniprotkb:MRT4(gene name synonym)|uniprotkb:Ribosome assembly factor MRTO4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000053372(gene)|ensembl:ENST00000330263(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:Q9UKD2|interpro:IPR033867|refseq:NP_057267.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LpvX3By1Cp6MxlAx3d5qoDM3FNY9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96QK1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054634|uniprotkb:Q561W2|uniprotkb:Q9H016|uniprotkb:Q9H096|uniprotkb:Q9H4P3|uniprotkb:Q9H8J0|uniprotkb:Q9NRS7|uniprotkb:Q9NVG2|uniprotkb:Q9NX80|uniprotkb:Q9NZK2|ensembl:ENSP00000299138	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vps35_human(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:VPS35(gene name)|psi-mi:VPS35(display_short)|uniprotkb:MEM3(gene name synonym)|uniprotkb:TCCCTA00141(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060676.2|rcsb pdb:5F0J|rcsb pdb:5F0K|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:7BLN|rcsb pdb:7BLO|reactome:R-HSA-3238698|ensembl:ENSG00000069329(gene)|ensembl:ENST00000299138(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097422"(tubular endosome)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|rcsb pdb:2R17|dip:DIP-29076N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:EXkMduDQKNCdp876vGF5vna9t389606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75369	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352089|intact:EBI-1754974|uniprotkb:Q13706|uniprotkb:Q59EC2|uniprotkb:Q6MZJ1|uniprotkb:Q8WXS9|uniprotkb:Q8WXT0|uniprotkb:Q8WXT1|uniprotkb:Q8WXT2|uniprotkb:Q9NRB5|uniprotkb:B2ZZ84|uniprotkb:Q9NT26|uniprotkb:Q9UEV9|intact:EBI-1960054|uniprotkb:C9JKE6|uniprotkb:B2ZZ85|uniprotkb:C9JMC4|ensembl:ENSP00000295956|uniprotkb:B2ZZ83|uniprotkb:Q60FE7|uniprotkb:Q8WXT3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flnb_human(display_long)|uniprotkb:FLNB(gene name)|psi-mi:FLNB(display_short)|uniprotkb:FLN1L(gene name synonym)|uniprotkb:FLN3(gene name synonym)|uniprotkb:TABP(gene name synonym)|uniprotkb:TAP(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Thyroid autoantigen(gene name synonym)|uniprotkb:Truncated actin-binding protein(gene name synonym)|uniprotkb:ABP-280 homolog(gene name synonym)|uniprotkb:ABP-278(gene name synonym)|uniprotkb:Filamin-3(gene name synonym)|uniprotkb:Filamin homolog 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001157791.1|refseq:NP_001448.2|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:O75369|rcsb pdb:2DI8|rcsb pdb:2DI9|rcsb pdb:2DIA|rcsb pdb:2DIB|rcsb pdb:2DIC|rcsb pdb:2DJ4|rcsb pdb:2DLG|rcsb pdb:2DMB|rcsb pdb:2DMC|rcsb pdb:2E9I|rcsb pdb:2E9J|rcsb pdb:2EE6|rcsb pdb:2EE9|rcsb pdb:2EEA|rcsb pdb:2EEB|rcsb pdb:2EEC|rcsb pdb:2EED|rcsb pdb:2WA5|rcsb pdb:2WA6|rcsb pdb:2WA7|rcsb pdb:3FER|rcsb pdb:4B7L|rcsb pdb:5DCP|reactome:R-HSA-1169408|ensembl:ENSG00000136068(gene)|ensembl:ENST00000295956(transcript)|go:"GO:0001725"(stress fiber)|refseq:NP_001157789.1|refseq:NP_001157790.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lsf6C/Vg0io7UhUi1Kapgwp0p5E9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25205	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30048	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748336|intact:EBI-10975142|uniprotkb:P35690|uniprotkb:Q0D2H1|uniprotkb:Q13776|uniprotkb:Q5T5V2|uniprotkb:Q96HK4|uniprotkb:B2R7Z0|uniprotkb:D3DRC9|uniprotkb:E9PH29|ensembl:ENSP00000298510	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx3_human(display_long)|uniprotkb:Peroxiredoxin-3(gene name synonym)|uniprotkb:Peroxiredoxin III(gene name synonym)|uniprotkb:Antioxidant protein 1(gene name synonym)|uniprotkb:Protein MER5 homolog(gene name synonym)|uniprotkb:HBC189(gene name synonym)|uniprotkb:PRDX3(gene name)|psi-mi:PRDX3(display_short)|uniprotkb:AOP1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001289201.1|refseq:NP_006784.1|ensembl:ENSG00000165672(gene)|ensembl:ENST00000298510(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008785"(alkyl hydroperoxide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:P30048|rcsb pdb:5JCG|rcsb pdb:5UCX|reactome:R-HSA-3299685|go:"GO:0005769"(early endosome)|dip:DIP-33600N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+J/zV8u0jGCSzTGXafxgecTv/149606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07195	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00567	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-396034|uniprotkb:Q2M3T6|uniprotkb:Q9NQ05|ensembl:ENSP00000370589	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nop56_human(display_long)|uniprotkb:NOP56(gene name)|psi-mi:NOP56(display_short)|uniprotkb:NOL5A(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006383.2|ensembl:ENSG00000101361(gene)|ensembl:ENST00000329276(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:O00567|reactome:R-HSA-390471|reactome:R-HSA-6790901|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nXIsxj5Spl+kflK0yGJFykVylmA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14174	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372712|uniprotkb:A5Z1R8|uniprotkb:B2R4S3|uniprotkb:Q6FHV0|uniprotkb:Q2V4Y5|ensembl:ENSP00000215754|ensembl:ENSP00000482779	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mif_human(display_long)|uniprotkb:MIF(gene name)|psi-mi:MIF(display_short)|uniprotkb:MMIF(gene name synonym)|uniprotkb:GLIF(gene name synonym)|uniprotkb:Phenylpyruvate tautomerase(gene name synonym)|uniprotkb:Glycosylation-inhibiting factor(gene name synonym)|uniprotkb:L-dopachrome tautomerase(gene name synonym)|uniprotkb:L-dopachrome isomerase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002406.1|ensembl:ENST00000215754(transcript)|ensembl:ENST00000613839(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004167"(dopachrome isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000276701(gene)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031982"(vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000240972(gene)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045087"(innate immune response)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050178"(phenylpyruvate tautomerase activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001398(Macrophage migration inhibitory factor)|interpro:IPR014347(Tautomerase)|interpro:IPR019829|mint:P14174|rcsb pdb:1CGQ|rcsb pdb:1GCZ|rcsb pdb:1GD0|rcsb pdb:1GIF|rcsb pdb:1LJT|rcsb pdb:1MIF|rcsb pdb:1P1G|rcsb pdb:2OOH|rcsb pdb:2OOW|rcsb pdb:2OOZ|rcsb pdb:3B9S|rcsb pdb:3CE4|rcsb pdb:3DJH|rcsb pdb:3DJI|rcsb pdb:3HOF|rcsb pdb:3IJG|rcsb pdb:3IJJ|rcsb pdb:3JSF|rcsb pdb:3JSG|rcsb pdb:3JTU|rcsb pdb:3L5P|rcsb pdb:3L5R|rcsb pdb:3L5S|rcsb pdb:3L5T|rcsb pdb:3L5U|rcsb pdb:3L5V|rcsb pdb:3SMB|rcsb pdb:3SMC|rcsb pdb:3U18|rcsb pdb:3WNR|rcsb pdb:3WNS|rcsb pdb:3WNT|rcsb pdb:4ETG|rcsb pdb:4EUI|rcsb pdb:4EVG|rcsb pdb:4F2K|rcsb pdb:4GRN|rcsb pdb:4GRO|rcsb pdb:4GRP|rcsb pdb:4GRQ|rcsb pdb:4GRR|rcsb pdb:4GRU|rcsb pdb:4GUM|rcsb pdb:4K9G|rcsb pdb:4OSF|rcsb pdb:4OYQ|rcsb pdb:4P01|rcsb pdb:4P0H|rcsb pdb:4PKK|rcsb pdb:4PKZ|rcsb pdb:4PLU|rcsb pdb:4TRF|rcsb pdb:4TRU|rcsb pdb:4WR8|rcsb pdb:4WRB|rcsb pdb:4XX7|rcsb pdb:4XX8|rcsb pdb:4Z15|rcsb pdb:4Z1T|rcsb pdb:4Z1U|rcsb pdb:5B4O|rcsb pdb:5BS9|rcsb pdb:5BSC|rcsb pdb:5BSI|rcsb pdb:5BSJ|rcsb pdb:5EIZ|rcsb pdb:5HVS|rcsb pdb:5HVT|rcsb pdb:5HVV|rcsb pdb:5J7P|rcsb pdb:5J7Q|rcsb pdb:5UMJ|rcsb pdb:5UMK|rcsb pdb:5UZY|rcsb pdb:5V70|rcsb pdb:5V73|rcsb pdb:5XEJ|rcsb pdb:1CA7|rcsb pdb:6B1C|rcsb pdb:6B1K|rcsb pdb:6B2C|rcsb pdb:6BG6|rcsb pdb:6BG7|rcsb pdb:6CB5|rcsb pdb:6CBF|rcsb pdb:6CBG|rcsb pdb:6FVE|rcsb pdb:6FVH|rcsb pdb:6OY8|rcsb pdb:6OYB|rcsb pdb:6OYE|rcsb pdb:6OYG|rcsb pdb:6PEG|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-8950505|rcsb pdb:6CBH|dip:DIP-31137N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Vk+Sfaz5c59y8dKKJ4Qn+7fjwvQ9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46779	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366357|uniprotkb:Q6IAY0|uniprotkb:Q96FX1|uniprotkb:Q9BWQ0|uniprotkb:B2R4A6|uniprotkb:B4DEP9|uniprotkb:E9PB24|uniprotkb:C9JB50|uniprotkb:G5E9L2|ensembl:ENSP00000342787|ensembl:ENSP00000453319	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl28_human(display_long)|uniprotkb:RPL28(gene name)|psi-mi:RPL28(display_short)|uniprotkb:Large ribosomal subunit protein eL28(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129608.1|refseq:NP_001129609.1|refseq:NP_000982.2|refseq:NP_001129606.1|refseq:NP_001129607.1|ensembl:ENSG00000108107(gene)|ensembl:ENST00000344063(transcript)|ensembl:ENST00000559463(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002672(Ribosomal protein L28e)|interpro:IPR029004|mint:P46779|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I7Me1zjfxk98g6C2NoYOWlmrYVc9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3F4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727414|uniprotkb:Q9UQC8|uniprotkb:Q9NTK0|uniprotkb:Q5TZT4|intact:EBI-6190807|uniprotkb:B4DNJ6|uniprotkb:B2R5S5|ensembl:ENSP00000392270	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:strap_human(display_long)|uniprotkb:UNR-interacting protein(gene name synonym)|uniprotkb:WD-40 repeat protein PT-WD(gene name synonym)|uniprotkb:MAP activator with WD repeats(gene name synonym)|uniprotkb:STRAP(gene name)|psi-mi:STRAP(display_short)|uniprotkb:MAWD(gene name synonym)|uniprotkb:UNRIP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009109.3|ensembl:ENSG00000023734(gene)|ensembl:ENST00000419869(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:Q9Y3F4|reactome:R-HSA-2173788	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/IqZt6BHPxD3S/THUZry4+QUvCE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q53FZ2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190543|ensembl:ENSP00000289416|uniprotkb:O60363|uniprotkb:Q13732|uniprotkb:Q15425|uniprotkb:Q7KYM6|uniprotkb:Q9BUA2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:acsm3_human(display_long)|uniprotkb:Propionate--CoA ligase(gene name synonym)|uniprotkb:ACSM3(gene name)|psi-mi:ACSM3(display_short)|uniprotkb:SAH(gene name synonym)|uniprotkb:Acyl-CoA synthetase medium-chain family member 3(gene name synonym)|uniprotkb:Butyrate--CoA ligase 3(gene name synonym)|uniprotkb:Butyryl-coenzyme A synthetase 3(gene name synonym)|uniprotkb:Middle-chain acyl-CoA synthetase 3(gene name synonym)|uniprotkb:Protein SA homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR042099|reactome:R-HSA-77352|go:"GO:0047760"(butyrate-CoA ligase activity)|ensembl:ENSG00000005187(gene)|ensembl:ENST00000289416(transcript)|go:"GO:0004321"(fatty-acyl-CoA synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015645"(fatty acid ligase activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043759"(methylbutanoate-CoA ligase activity)|go:"GO:0046872"(metal ion binding)|refseq:NP_005613.2|refseq:NP_973729.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Do1rTLtpYet8Ez8zkBcq9SZnI8g9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25789	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359310|uniprotkb:Q8TBD1|uniprotkb:Q53XP2|ensembl:ENSP00000044462|ensembl:ENSP00000453887|uniprotkb:D3DW86|uniprotkb:Q567Q5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa4_human(display_long)|uniprotkb:PSMA4(gene name)|psi-mi:PSMA4(display_short)|uniprotkb:PSC9(gene name synonym)|uniprotkb:Proteasome component C9(gene name synonym)|uniprotkb:Macropain subunit C9(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C9(gene name synonym)|uniprotkb:Proteasome subunit L(gene name synonym)|uniprotkb:HC9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001096137.1|refseq:NP_002780.1|rcsb pdb:6XMJ|reactome:R-HSA-2467813|reactome:R-HSA-2871837|rcsb pdb:7AWE|reactome:R-HSA-349425|reactome:R-HSA-1169091|reactome:R-HSA-350562|reactome:R-HSA-1234176|reactome:R-HSA-382556|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-450408|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5358346|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000041357(gene)|ensembl:ENST00000044462(transcript)|ensembl:ENST00000559082(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034647|mint:P25789|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|refseq:NP_001096138.1|refseq:NP_001317605.1|dip:DIP-29365N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u+wKxvIa9JKb4Zu9K+tnY3d26tw9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PB61	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190851|ensembl:ENSP00000421592	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pb61_human(display_long)|uniprotkb:ALYREF(gene name)|psi-mi:ALYREF(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000183684(gene)|ensembl:ENST00000505490(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR025715|interpro:IPR035979|go:"GO:0016607"(nuclear speck)|refseq:NP_005773.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1TYm+flGafmObpUMr0SV5tuEDR49606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14818	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-603272|uniprotkb:Q9BR53|uniprotkb:Q9H4K5|uniprotkb:Q9UEU8|uniprotkb:B2R515|uniprotkb:Q5JXJ2|ensembl:ENSP00000359910	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa7_human(display_long)|uniprotkb:PSMA7(gene name)|psi-mi:PSMA7(display_short)|uniprotkb:Proteasome subunit RC6-1(gene name synonym)|uniprotkb:Proteasome subunit XAPC7(gene name synonym)|uniprotkb:HSPC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002783.1|dip:DIP-29363N|ensembl:ENSG00000101182(gene)|ensembl:ENST00000370873(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098794"(postsynapse)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035190|mint:O14818|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:J1M+b+VK02BAn2OnZISjjlmO8dc9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62249	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352480|uniprotkb:P17008|uniprotkb:B2RDD5|ensembl:ENSP00000251453	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs16_human(display_long)|uniprotkb:RPS16(gene name)|psi-mi:RPS16(display_short)|uniprotkb:Small ribosomal subunit protein uS9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001011.1|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000105193(gene)|ensembl:ENST00000251453(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097421"(liver regeneration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P62249|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|dip:DIP-33200N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OrKriR6HsATLaO+drdUa2w3Gpd09606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06733	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95777	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347779|ensembl:ENSP00000249299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35908	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1247312|uniprotkb:Q4VAQ2|ensembl:ENSP00000310861	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k22e_human(display_long)|uniprotkb:KRT2(gene name)|psi-mi:KRT2(display_short)|uniprotkb:KRT2A(gene name synonym)|uniprotkb:KRT2E(gene name synonym)|uniprotkb:Cytokeratin-2e(gene name synonym)|uniprotkb:Keratin-2e(gene name synonym)|uniprotkb:Type-II keratin Kb2(gene name synonym)|uniprotkb:Keratin-2 epidermis(gene name synonym)|uniprotkb:Epithelial keratin-2e(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000414.2|ensembl:ENSG00000172867(gene)|ensembl:ENST00000309680(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0031424"(keratinization)|go:"GO:0032980"(keratinocyte activation)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P35908|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0051546"(keratinocyte migration)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:T7LeB8nkZzNjUb8DWdkxbrl5f789606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16658	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351076|uniprotkb:Q96IH1|uniprotkb:A6NI89|uniprotkb:Q96IC5|uniprotkb:Q9BRF1|uniprotkb:B2RE97|ensembl:ENSP00000371798	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fscn1_human(display_long)|uniprotkb:FSCN1(gene name)|psi-mi:FSCN1(display_short)|uniprotkb:FAN1(gene name synonym)|uniprotkb:HSN(gene name synonym)|uniprotkb:SNL(gene name synonym)|uniprotkb:Singed-like protein(gene name synonym)|uniprotkb:55 kDa actin-bundling protein(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0044393"(microspike)|go:"GO:0045296"(cadherin binding)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR008999(Actin_cross-linking)|interpro:IPR010431(Fascin)|interpro:IPR022768|interpro:IPR024703|interpro:IPR030146|mint:Q16658|rcsb pdb:1DFC|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030035"(microspike assembly)|rcsb pdb:3LLP|refseq:NP_003079.1|ensembl:ENSG00000075618(gene)|ensembl:ENST00000382361(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008144"(obsolete drug binding)|rcsb pdb:3P53|rcsb pdb:4GOV|rcsb pdb:4GOY|rcsb pdb:4GP3|rcsb pdb:6B0T|rcsb pdb:6I0Z|rcsb pdb:6I10|rcsb pdb:6I11|rcsb pdb:6I12|rcsb pdb:6I13|rcsb pdb:6I14|rcsb pdb:6I15|rcsb pdb:6I16|rcsb pdb:6I17|rcsb pdb:6I18|reactome:R-HSA-6785807|rcsb pdb:4GP0|dip:DIP-33171N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yc9EJDCKGJGGEcEueR/yAY/fxRg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17858	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-487243|uniprotkb:Q96A64|uniprotkb:Q96IH4|uniprotkb:Q9BR91|ensembl:ENSP00000269848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfkal_human(display_long)|uniprotkb:PFKL(gene name)|psi-mi:PFKL(display_short)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme B(gene name synonym)|uniprotkb:6-phosphofructokinase type B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002021.2|refseq:NP_002617.3|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P17858|reactome:R-HSA-6798695|reactome:R-HSA-70171|ensembl:ENSG00000141959(gene)|ensembl:ENST00000349048(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lP9/V5WcCl5rLpy4QEZnWkLCCcQ9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28072	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62910	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-438408|ensembl:ENSP00000380156|ensembl:ENSP00000380158|ensembl:ENSP00000388674|ensembl:ENSP00000416429|uniprotkb:P02433|uniprotkb:B2R4Q3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl32_human(display_long)|uniprotkb:RPL32(gene name)|psi-mi:RPL32(display_short)|uniprotkb:Large ribosomal subunit protein eL32(gene name synonym)|uniprotkb:PP9932(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000144713(gene)|ensembl:ENST00000396953(transcript)|ensembl:ENST00000396957(transcript)|ensembl:ENST00000429711(transcript)|ensembl:ENST00000435983(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR001515(Ribosomal protein L32e)|interpro:IPR018263|interpro:IPR036351|mint:P62910|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000985.1|refseq:NP_001007074.1|refseq:NP_001007075.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Yhph2ETzWYd07yJcq1cVqsSRjo9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1045046|uniprotkb:Q86YC1|uniprotkb:A6H8X3|ensembl:ENSP00000285968	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu205_human(display_long)|uniprotkb:Nucleoporin Nup205(gene name synonym)|uniprotkb:205 kDa nucleoporin(gene name synonym)|uniprotkb:NUP205(gene name)|psi-mi:NUP205(display_short)|uniprotkb:C7orf14(gene name synonym)|uniprotkb:KIAA0225(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000155561(gene)|ensembl:ENST00000285968(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|interpro:IPR021827|mint:Q92621|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:NP_055950.1|refseq:NP_001316363.1|dip:DIP-44021N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5lulE2tOZ4V1UZPwkEvOo9reZWE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UKM9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714796|uniprotkb:Q14621|uniprotkb:Q2M365|uniprotkb:Q5QPL8|uniprotkb:Q9BQX6|uniprotkb:Q9UJE3|ensembl:ENSP00000246194	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:raly_human(display_long)|uniprotkb:hnRNP associated with lethal yellow protein homolog(gene name synonym)|uniprotkb:Autoantigen p542(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein C-like 2(gene name synonym)|uniprotkb:RALY(gene name)|psi-mi:RALY(display_short)|uniprotkb:P542(gene name synonym)|uniprotkb:HNRPCL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011526996.1|refseq:XP_011526997.1|ensembl:ENSG00000125970(gene)|ensembl:ENST00000246194(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR034502|interpro:IPR035979|mint:Q9UKM9|rcsb pdb:1WF1|refseq:NP_031393.2|refseq:NP_057951.1|refseq:XP_005260391.1|refseq:XP_005260393.1|refseq:XP_016883220.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3hd0n2UW0FSRNvSJa2mqflVeorc9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61604	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711483|uniprotkb:O95421|uniprotkb:Q04984|uniprotkb:Q53X54|ensembl:ENSP00000233893|uniprotkb:Q9UDH0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ch10_human(display_long)|uniprotkb:HSPE1(gene name)|psi-mi:HSPE1(display_short)|uniprotkb:10 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 10(gene name synonym)|uniprotkb:Early-pregnancy factor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR020818|interpro:IPR037124|mint:P61604|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|reactome:R-HSA-9013408|ensembl:ENSG00000115541(gene)|ensembl:ENST00000233893(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011032(GroES-like)|interpro:IPR018369|refseq:NP_002148.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BmnGoMnA2QIr3Dr0fElMtTgRztA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48047	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15691	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1004115|uniprotkb:Q3KQS8|uniprotkb:B2R6I7|uniprotkb:E1P5M8|ensembl:ENSP00000364721	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mare1_human(display_long)|uniprotkb:APC-binding protein EB1(gene name synonym)|uniprotkb:End-binding protein 1(gene name synonym)|uniprotkb:MAPRE1(gene name)|psi-mi:MAPRE1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036457.1|refseq:XP_011526998.1|ensembl:ENSG00000101367(gene)|ensembl:ENST00000375571(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0016477"(cell migration)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:1903033"(positive regulation of microtubule plus-end binding)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:1904825"(protein localization to microtubule plus-end)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1905721"(mitotic spindle astral microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR004953(EB1, C-terminal)|interpro:IPR027328|interpro:IPR027739|interpro:IPR036133|interpro:IPR036872|mint:Q15691|rcsb pdb:1PA7|rcsb pdb:1TXQ|rcsb pdb:1UEG|rcsb pdb:1VKA|rcsb pdb:1WU9|rcsb pdb:1YIB|rcsb pdb:1YIG|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2QJZ|rcsb pdb:2R8U|rcsb pdb:3GJO|rcsb pdb:3MTU|rcsb pdb:3MUD|rcsb pdb:3TQ7|rcsb pdb:4XA1|rcsb pdb:4XA3|rcsb pdb:4XA6|rcsb pdb:5JV3|rcsb pdb:5JVM|rcsb pdb:5JVP|rcsb pdb:5JVR|rcsb pdb:5JVS|rcsb pdb:5JVU|rcsb pdb:5JX1|rcsb pdb:5WLQ|rcsb pdb:6PF2|rcsb pdb:6PFP|rcsb pdb:6YF5|rcsb pdb:6YSH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|dip:DIP-38018N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+JBCBM7dbbrxn6mX8RiwejYWJ2U9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UNM6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356070|uniprotkb:O75831|uniprotkb:Q9UNV3|uniprotkb:Q53XU2|intact:EBI-1058479|uniprotkb:B3KT15|ensembl:ENSP00000436186	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd13_human(display_long)|uniprotkb:PSMD13(gene name)|psi-mi:PSMD13(display_short)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002808.3|refseq:NP_787128.2|dip:DIP-27576N|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:6MSK|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000185627(gene)|ensembl:ENST00000532097(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007127"(meiosis I)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|mint:Q9UNM6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iOxE62MMeGx+aqsrir/LukJqeho9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99873	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P10599	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-594644|uniprotkb:B1ALW1|uniprotkb:O60744|uniprotkb:Q53X69|uniprotkb:Q96KI3|uniprotkb:Q9UDG5|intact:EBI-1042712|ensembl:ENSP00000363641	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:thio_human(display_long)|uniprotkb:ATL-derived factor(gene name synonym)|uniprotkb:Surface-associated sulphydryl protein(gene name synonym)|uniprotkb:TXN(gene name)|psi-mi:TXN(display_short)|uniprotkb:TRDX(gene name synonym)|uniprotkb:TRX(gene name synonym)|uniprotkb:TRX1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003320.2|refseq:NP_001231867.1|dip:DIP-6129N|ensembl:ENSG00000136810(gene)|ensembl:ENST00000374517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006662"(glycerol ether metabolic process)|go:"GO:0009314"(response to radiation)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071731"(response to nitric oxide)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR005746(Thioredoxin)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P10599|rcsb pdb:1AIU|rcsb pdb:1AUC|rcsb pdb:1CQG|rcsb pdb:1CQH|rcsb pdb:1ERT|rcsb pdb:1ERU|rcsb pdb:1ERV|rcsb pdb:1ERW|rcsb pdb:1M7T|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1TRS|rcsb pdb:1TRU|rcsb pdb:1TRV|rcsb pdb:1TRW|rcsb pdb:1W1C|rcsb pdb:1W1E|rcsb pdb:2HSH|rcsb pdb:2HXK|rcsb pdb:2IFQ|rcsb pdb:2IIY|rcsb pdb:3E3E|rcsb pdb:3KD0|rcsb pdb:3M9J|rcsb pdb:3M9K|rcsb pdb:3QFA|rcsb pdb:3QFB|rcsb pdb:3TRX|rcsb pdb:4LL1|rcsb pdb:4LL4|rcsb pdb:4OO4|rcsb pdb:4OO5|rcsb pdb:4POK|rcsb pdb:4POL|rcsb pdb:4POM|rcsb pdb:4PUF|rcsb pdb:4TRX|rcsb pdb:5DQY|reactome:R-HSA-2559580|reactome:R-HSA-3299685|reactome:R-HSA-499943|reactome:R-HSA-5628897|reactome:R-HSA-5676934|reactome:R-HSA-844456|reactome:R-HSA-9617629|reactome:R-HSA-9660826	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5u+iJJtwAwAKXljKHnpY8h5uRkQ9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62805	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302023|ensembl:ENSP00000244537|ensembl:ENSP00000347168|ensembl:ENSP00000350767|ensembl:ENSP00000366974|ensembl:ENSP00000366956|ensembl:ENSP00000462667|ensembl:ENSP00000367034|ensembl:ENSP00000478519|ensembl:ENSP00000478786|ensembl:ENSP00000443017|ensembl:ENSP00000462355|ensembl:ENSP00000479106|ensembl:ENSP00000479461|uniprotkb:A2VCL0|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6DRA9|uniprotkb:Q6FGB8|uniprotkb:Q6NWP7|ensembl:ENSP00000479794|ensembl:ENSP00000480960|ensembl:ENSP00000481343|ensembl:ENSP00000481486|ensembl:ENSP00000481507|ensembl:ENSP00000482412|ensembl:ENSP00000484789|ensembl:ENSP00000489319|ensembl:ENSP00000489567	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h4_human(display_long)|uniprotkb:H4-16(gene name)|psi-mi:H4-16(display_short)|uniprotkb:H4C1(gene name)|psi-mi:H4C1(display_short)|uniprotkb:H4C11(gene name)|psi-mi:H4C11(display_short)|uniprotkb:H4C12(gene name)|psi-mi:H4C12(display_short)|uniprotkb:H4C13(gene name)|psi-mi:H4C13(display_short)|uniprotkb:H4C14(gene name)|psi-mi:H4C14(display_short)|uniprotkb:H4C15(gene name)|psi-mi:H4C15(display_short)|uniprotkb:H4C2(gene name)|psi-mi:H4C2(display_short)|uniprotkb:H4C3(gene name)|psi-mi:H4C3(display_short)|uniprotkb:H4C4(gene name)|psi-mi:H4C4(display_short)|uniprotkb:H4C5(gene name)|psi-mi:H4C5(display_short)|uniprotkb:H4C6(gene name)|psi-mi:H4C6(display_short)|uniprotkb:H4C8(gene name)|psi-mi:H4C8(display_short)|uniprotkb:H4C9(gene name)|psi-mi:H4C9(display_short)|uniprotkb:H4/A(gene name synonym)|uniprotkb:H4/B(gene name synonym)|uniprotkb:H4/C(gene name synonym)|uniprotkb:H4/D(gene name synonym)|uniprotkb:H4/E(gene name synonym)|uniprotkb:H4/G(gene name synonym)|uniprotkb:H4/H(gene name synonym)|uniprotkb:H4/I(gene name synonym)|uniprotkb:H4/J(gene name synonym)|uniprotkb:H4/K(gene name synonym)|uniprotkb:H4/M(gene name synonym)|uniprotkb:H4/N(gene name synonym)|uniprotkb:H4/O(gene name synonym)|uniprotkb:H4F2(gene name synonym)|uniprotkb:H4FA(gene name synonym)|uniprotkb:H4FB(gene name synonym)|uniprotkb:H4FC(gene name synonym)|uniprotkb:H4FD(gene name synonym)|uniprotkb:H4FE(gene name synonym)|uniprotkb:H4FG(gene name synonym)|uniprotkb:H4FH(gene name synonym)|uniprotkb:H4FI(gene name synonym)|uniprotkb:H4FJ(gene name synonym)|uniprotkb:H4FK(gene name synonym)|uniprotkb:H4FM(gene name synonym)|uniprotkb:H4FN(gene name synonym)|uniprotkb:H4FO(gene name synonym)|uniprotkb:HIST1H4A(gene name synonym)|uniprotkb:HIST1H4B(gene name synonym)|uniprotkb:HIST1H4C(gene name synonym)|uniprotkb:HIST1H4D(gene name synonym)|uniprotkb:HIST1H4E(gene name synonym)|uniprotkb:HIST1H4F(gene name synonym)|uniprotkb:HIST1H4H(gene name synonym)|uniprotkb:HIST1H4I(gene name synonym)|uniprotkb:HIST1H4J(gene name synonym)|uniprotkb:HIST1H4K(gene name synonym)|uniprotkb:HIST1H4L(gene name synonym)|uniprotkb:HIST2H4(gene name synonym)|uniprotkb:HIST2H4A(gene name synonym)|uniprotkb:HIST2H4B(gene name synonym)|uniprotkb:HIST4H4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000197061(gene)|ensembl:ENSG00000276180(gene)|ensembl:ENSG00000197238(gene)|ensembl:ENSG00000276966(gene)|ensembl:ENSG00000277157(gene)|ensembl:ENSG00000270276(gene)|ensembl:ENSG00000197837(gene)|ensembl:ENSG00000270882(gene)|ensembl:ENSG00000278637(gene)|ensembl:ENSG00000273542(gene)|ensembl:ENSG00000274618(gene)|ensembl:ENSG00000278705(gene)|ensembl:ENSG00000275126(gene)|ensembl:ENSG00000158406(gene)|dip:DIP-33079N|ensembl:ENST00000244537(transcript)|ensembl:ENST00000355057(transcript)|ensembl:ENST00000358064(transcript)|ensembl:ENST00000377727(transcript)|ensembl:ENST00000377745(transcript)|ensembl:ENST00000377803(transcript)|ensembl:ENST00000539745(transcript)|ensembl:ENST00000578186(transcript)|ensembl:ENST00000579512(transcript)|ensembl:ENST00000611927(transcript)|ensembl:ENST00000612061(transcript)|ensembl:ENST00000613412(transcript)|ensembl:ENST00000614247(transcript)|ensembl:ENST00000614272(transcript)|ensembl:ENST00000615164(transcript)|ensembl:ENST00000615353(transcript)|ensembl:ENST00000617569(transcript)|ensembl:ENST00000618193(transcript)|ensembl:ENST00000618305(transcript)|ensembl:ENST00000621520(transcript)|ensembl:ENST00000634560(transcript)|ensembl:ENST00000634956(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0005576"(extracellular region)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AYW|rcsb pdb:3AZJ|rcsb pdb:3AZK|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:3F9W|rcsb pdb:3F9X|rcsb pdb:3F9Y|rcsb pdb:3F9Z|rcsb pdb:3IJ1|rcsb pdb:3JPX|rcsb pdb:3NQJ|rcsb pdb:3NQU|rcsb pdb:3O36|rcsb pdb:3QBY|rcsb pdb:3QZS|rcsb pdb:3QZT|rcsb pdb:3QZV|rcsb pdb:3R45|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3WTP|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:4GQB|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:4M38|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4QUT|rcsb pdb:4QUU|rcsb pdb:4QYD|rcsb pdb:4U9W|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4YY6|rcsb pdb:4YYD|rcsb pdb:4YYG|rcsb pdb:4YYH|rcsb pdb:4YYI|rcsb pdb:4YYJ|rcsb pdb:4YYK|rcsb pdb:4YYM|rcsb pdb:4YYN|rcsb pdb:4Z2M|rcsb pdb:4Z5T|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5AY8|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B2J|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5B40|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5CPI|interpro:IPR019809|interpro:IPR035425|mint:P62805|rcsb pdb:1ZKK|rcsb pdb:2BQZ|rcsb pdb:2CV5|rcsb pdb:2IG0|rcsb pdb:2KWN|rcsb pdb:2KWO|rcsb pdb:2LVM|rcsb pdb:2QQS|rcsb pdb:2RJE|rcsb pdb:2RNY|interpro:IPR009072(Histone-fold)|rcsb pdb:2RS9|rcsb pdb:3A6N|rcsb pdb:3AFA|rcsb pdb:3AN2|rcsb pdb:3AV1|rcsb pdb:3AV2|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5GXQ|rcsb pdb:5JA4|rcsb pdb:5JRG|rcsb pdb:5KDM|rcsb pdb:5TEG|rcsb pdb:5X7X|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5YE3|rcsb pdb:5YE4|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:5ZBX|rcsb pdb:5ZGC|rcsb pdb:5CPJ|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:5CPK|rcsb pdb:6A5P|rcsb pdb:5FA5|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6ACP|rcsb pdb:6BUZ|rcsb pdb:6C0W|rcsb pdb:6E0C|rcsb pdb:6E0P|rcsb pdb:6FML|rcsb pdb:6HKT|rcsb pdb:6HTS|rcsb pdb:6INQ|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6KXV|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:5FFW|rcsb pdb:5FWE|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MLC|rcsb pdb:6MUO|rcsb pdb:6MUP|rcsb pdb:6O1D|rcsb pdb:6R0C|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|refseq:NP_001029249.1|refseq:NP_003486.1|refseq:NP_003529.1|refseq:NP_003530.1|refseq:NP_003531.1|refseq:NP_003532.1|refseq:NP_003533.1|refseq:NP_003534.1|refseq:NP_003535.1|refseq:NP_003536.1|refseq:NP_003537.1|refseq:NP_003539.1|rcsb pdb:6R92|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6RNY|rcsb pdb:6RXS|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2K|rcsb pdb:6V92|rcsb pdb:6VO5|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6YOV|rcsb pdb:7A08|rcsb pdb:7BWD|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:7CCR|rcsb pdb:7CIZ|rcsb pdb:7CJ0|rcsb pdb:7D1Z|rcsb pdb:7D20|rcsb pdb:7DBP|rcsb pdb:7JO9|rcsb pdb:7JOA|rcsb pdb:7JZV|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7LMK|rcsb pdb:7LMM|rcsb pdb:7LYC|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|refseq:NP_068803.1|refseq:NP_778224.1|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60842	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73449|uniprotkb:P04765|uniprotkb:Q5U018|uniprotkb:Q61516|uniprotkb:B2R6L8|uniprotkb:D3DTP9|uniprotkb:J3QLC4|ensembl:ENSP00000293831	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4a1_human(display_long)|uniprotkb:EIF4A1(gene name)|psi-mi:EIF4A1(display_short)|uniprotkb:EIF4A(gene name synonym)|uniprotkb:DDX2A(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001407.1|refseq:NP_001191439.1|dip:DIP-29755N|ensembl:ENSG00000161960(gene)|ensembl:ENST00000293831(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P60842|rcsb pdb:2G9N|rcsb pdb:2ZU6|rcsb pdb:3EIQ|rcsb pdb:5ZBZ|rcsb pdb:5ZC9|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e+2gp47oHrpxFbrBFSM4qTf3r7E9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6P2E9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62266	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353072|ensembl:ENSP00000296674|ensembl:ENSP00000498621|uniprotkb:P39028|uniprotkb:Q6IB08	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs23_human(display_long)|uniprotkb:RPS23(gene name)|psi-mi:RPS23(display_short)|uniprotkb:Small ribosomal subunit protein uS12(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000186468(gene)|ensembl:ENST00000296674(transcript)|ensembl:ENST00000651545(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:1990145"(maintenance of translational fidelity)|interpro:IPR005680(Ribosomal protein S23, eukaryotic/archaeal)|interpro:IPR006032(Ribosomal protein S12/S23)|rcsb pdb:5T2C|rcsb pdb:5VYC|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|mint:P62266|rcsb pdb:6G4W|rcsb pdb:4CXG|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:4CXH|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:4UG0|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|refseq:NP_001016.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MWZPvSL/G45ocaxA5AXKCkDQxNU9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02008	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-719843|uniprotkb:Q6IBF6|ensembl:ENSP00000252951	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbaz_human(display_long)|uniprotkb:Hemoglobin zeta chain(gene name synonym)|uniprotkb:Zeta-globin(gene name synonym)|uniprotkb:HBAZ(gene name synonym)|uniprotkb:HBZ(gene name)|psi-mi:HBZ(display_short)|uniprotkb:HBZ2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005323.1|ensembl:ENSG00000130656(gene)|ensembl:ENST00000252951(transcript)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002340(Haemoglobin, zeta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:1JEB|rcsb pdb:3W4U|refseq:XP_005255345.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:K2E42b7eK+PiEY1MPC/IepTjnOI9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43175	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BQG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-676973|intact:EBI-2559619|uniprotkb:Q86VM3|uniprotkb:Q9BW49|uniprotkb:Q9P0V5|uniprotkb:Q9UF99|ensembl:ENSP00000254718	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mbb1a_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)|uniprotkb:P160(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001099008.1|refseq:NP_055335.2|ensembl:ENST00000254718(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|ensembl:ENSG00000132382(gene)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q9BQG0|reactome:R-HSA-5250924	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ScabTPXvbX/5VRsnaRQXUIlANow9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52907	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355586|uniprotkb:Q53FQ6|uniprotkb:Q6FHD5|ensembl:ENSP00000263168	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:caza1_human(display_long)|uniprotkb:CAPZA1(gene name)|psi-mi:CAPZA1(display_short)|uniprotkb:CapZ alpha-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006126.1|ensembl:ENSG00000116489(gene)|ensembl:ENST00000263168(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P52907|rcsb pdb:1MQ1|rcsb pdb:1MWN|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-879415|reactome:R-HSA-8950505|reactome:R-HSA-9662360|reactome:R-HSA-983231	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:97S4WPtjgt4MDLoptRhQ2yH8UNE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P23528	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P00338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09661	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876439|uniprotkb:Q8TBD2|uniprotkb:B2R5I6|ensembl:ENSP00000254193	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ru2a_human(display_long)|uniprotkb:SNRPA1(gene name)|psi-mi:SNRPA1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003081.2|dip:DIP-625N|ensembl:ENSG00000131876(gene)|ensembl:ENST00000254193(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR044640|mint:P09661|rcsb pdb:1A9N|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|reactome:R-HSA-8950505	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tmZyAPCvMg34GY4kVc6NcnycOeE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08648	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P59998	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351872|uniprotkb:O15509|uniprotkb:C9JWM7|uniprotkb:E7ETI0|uniprotkb:Q6P0W5|uniprotkb:Q96QJ3|ensembl:ENSP00000380431|uniprotkb:F6TTL5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arpc4_human(display_long)|uniprotkb:ARPC4(gene name)|psi-mi:ARPC4(display_short)|uniprotkb:ARC20(gene name synonym)|uniprotkb:Arp2/3 complex 20 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001185709.1|refseq:NP_005709.1|ensembl:ENSG00000241553(gene)|ensembl:ENST00000397261(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045010"(actin nucleation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008384(ARP23 complex 20 kDa subunit)|interpro:IPR034666|mint:P59998|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|refseq:NP_001020130.1|refseq:NP_001020131.1|dip:DIP-33188N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Iqe60TWfO3QBVOY+fOqZd9JWfIE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31483	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3U8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057689|uniprotkb:Q6FIG1|uniprotkb:Q9UQF6|uniprotkb:B2R4Y1|uniprotkb:D6W634|ensembl:ENSP00000252543|ensembl:ENSP00000378081|ensembl:ENSP00000462609|ensembl:ENSP00000464342	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl36_human(display_long)|uniprotkb:RPL36(gene name)|psi-mi:RPL36(display_short)|uniprotkb:Large ribosomal subunit protein eL36(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056229.2|refseq:NP_378669.1|reactome:R-HSA-975957|mint:Q9Y3U8|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|interpro:IPR038097|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|rcsb pdb:6Y6X|ensembl:ENSG00000130255(gene)|ensembl:ENST00000347512(transcript)|ensembl:ENST00000394580(transcript)|ensembl:ENST00000577222(transcript)|ensembl:ENST00000579649(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000509(Ribosomal protein L36e)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lRlRMF2jV/UHr4SX95SSCFIEV+s9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9NVP1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-724378|ensembl:ENSP00000263239|uniprotkb:Q6GTZ9|uniprotkb:Q6IAU4|uniprotkb:Q92732|uniprotkb:Q9BQB7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx18_human(display_long)|uniprotkb:DEAD box protein 18(gene name synonym)|uniprotkb:Myc-regulated DEAD box protein(gene name synonym)|uniprotkb:DDX18(gene name)|psi-mi:DDX18(display_short)|uniprotkb:cPERP-D(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006764.3|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR025313|interpro:IPR027417|interpro:IPR044773|mint:Q9NVP1|rcsb pdb:3LY5|ensembl:ENSG00000088205(gene)|ensembl:ENST00000263239(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0071392"(cellular response to estradiol stimulus)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RmupZbt33/w1V7Uq5vnRO36j2Tc9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8IWZ3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359558|ensembl:ENSP00000354085|intact:EBI-948598|uniprotkb:A6NH85|uniprotkb:Q149P2|uniprotkb:Q8IWZ2|uniprotkb:Q8WY90|uniprotkb:Q96G77|uniprotkb:Q96GK0|uniprotkb:Q9H2U0|uniprotkb:Q9HA95|uniprotkb:Q9NWG4|uniprotkb:Q9UPR7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ankh1_human(display_long)|uniprotkb:Multiple ankyrin repeats single KH domain(gene name synonym)|uniprotkb:ANKHD1(gene name)|psi-mi:ANKHD1(display_short)|uniprotkb:HIV-1 Vpr-binding ankyrin repeat protein(gene name synonym)|uniprotkb:KIAA1085(gene name synonym)|uniprotkb:MASK(gene name synonym)|uniprotkb:VBARP(gene name synonym)|uniprotkb:PP2500(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000131503(gene)|ensembl:ENST00000360839(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|refseq:NP_001183959.1|refseq:NP_060217.1|refseq:NP_060448.1|refseq:NP_078944.2|refseq:NP_065741.3|ensembl:ENSP00000354085|ensembl:ENST00000394722|ensembl:ENSP00000378211|ensembl:ENST00000394723|ensembl:ENSP00000378212|ensembl:ENST00000616482|ensembl:ENSP00000478529|dip:DIP-36371N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yPjTR77ttPwAEMg8WHOzYJNcAhA9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60900	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357793|uniprotkb:P34062|uniprotkb:Q6IB60|uniprotkb:B2R7J9|uniprotkb:B4DQR4|uniprotkb:B4DXJ9|ensembl:ENSP00000261479	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa6_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short)|uniprotkb:PROS27(gene name synonym)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)|uniprotkb:27 kDa prosomal protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002782.1|refseq:NP_001269162.1|refseq:NP_001269163.1|refseq:XP_016876957.1|refseq:NP_001269161.1|ensembl:ENSG00000100902(gene)|ensembl:ENST00000261479(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0035639"(purine ribonucleoside triphosphate binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|mint:P60900|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29367N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/89606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55769	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712228|ensembl:ENSP00000215956|ensembl:ENSP00000383949|ensembl:ENSP00000497142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nh2l1_human(display_long)|uniprotkb:SNU13(gene name)|psi-mi:SNU13(display_short)|uniprotkb:High mobility group-like nuclear protein 2 homolog 1(gene name synonym)|uniprotkb:NHP2L1(gene name synonym)|uniprotkb:OTK27(gene name synonym)|uniprotkb:SNU13 homolog(gene name synonym)|uniprotkb:U4/U6.U5 small nuclear ribonucleoprotein SNU13(gene name synonym)|uniprotkb:U4/U6.U5 tri-snRNP 15.5 kDa protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100138(gene)|ensembl:ENST00000215956(transcript)|ensembl:ENST00000401959(transcript)|ensembl:ENST00000648674(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0007338"(single fertilization)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051117"(ATPase binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P55769|rcsb pdb:1E7K|rcsb pdb:2JNB|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_001003796.1|refseq:NP_004999.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZMkqsDfMCrTlT/kJxillOA8839E9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62851	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353054|ensembl:ENSP00000435096|ensembl:ENSP00000486392|uniprotkb:P25111|uniprotkb:B2R4M7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs25_human(display_long)|uniprotkb:RPS25(gene name)|psi-mi:RPS25(display_short)|uniprotkb:Small ribosomal subunit protein eS25(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000118181(gene)|ensembl:ENSG00000280831(gene)|ensembl:ENST00000527673(transcript)|ensembl:ENST00000628770(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004977(Ribosomal protein S25)|interpro:IPR036388|mint:P62851|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y0G|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:6ZXD|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|rcsb pdb:6ZXE|reactome:R-HSA-9010553|reactome:R-HSA-9633012|rcsb pdb:6ZXF|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|refseq:NP_001019.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7TqA4Q6+6VMzrzaUrACbwtJKfOM9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192398	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI0000073D6C|ipi:IPI00383111	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c10-like(display_short)|psi-mi:EBI-6192398(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.|comment:Probably contaminant.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zhw8GDGRkP65Pnm5ZMbBSMlTsqc9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192360	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI0000D6259C|ipi:IPI00744503	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hbg2-like(display_short)|psi-mi:EBI-6192360(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6191082|imex:IM-17358-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with a chimera of the beta-propeller domain of alpha-4 integrin (Thr1-Leu440) and the leg, transmembrane and cytosolic domains of alpha-5 integrin (Thr459-ala1008)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2018/04/06	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:L9FDFHlcKLLIb2AuVWClY2e7vhs9606	intact-crc:018F17F0C33AA72B|rigid:rPEZ1HdnVdQ0NJ76OOQyREFC840	false	mutation disrupting interaction:40-40|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18754	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-992720|uniprotkb:Q16269|uniprotkb:Q6NT97|ensembl:ENSP00000362939|ensembl:ENSP00000381931|ensembl:ENSP00000508074|ensembl:ENSP00000362938	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rcc1_human(display_long)|uniprotkb:Chromosome condensation protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein(gene name synonym)|uniprotkb:RCC1(gene name)|psi-mi:RCC1(display_short)|uniprotkb:CHC1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001041659.1|refseq:NP_001041660.1|refseq:NP_001041664.1|refseq:NP_001260.1|dip:DIP-35416N|ensembl:ENSG00000180198(gene)|ensembl:ENST00000373832(transcript)|ensembl:ENST00000373833(transcript)|ensembl:ENST00000398958(transcript)|ensembl:ENST00000683442(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003682"(chromatin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016032"(viral process)|rcsb pdb:5E1B|rcsb pdb:5E1D|rcsb pdb:5E1M|rcsb pdb:5E1O|rcsb pdb:5E2A|go:"GO:0031267"(small GTPase binding)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031492"(nucleosomal DNA binding)|rcsb pdb:5E2B|rcsb pdb:5TBK|rcsb pdb:6DUB|reactome:R-HSA-165054|go:"GO:0031965"(nuclear membrane)|reactome:R-HSA-180746|reactome:R-HSA-9615933|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:P18754|rcsb pdb:1A12|rcsb pdb:1I2M	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/gP2xQp6fUffHTXpXvs8eb5YJ209606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52594	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25205	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P17858	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-487243|uniprotkb:Q96A64|uniprotkb:Q96IH4|uniprotkb:Q9BR91|ensembl:ENSP00000269848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pfkal_human(display_long)|uniprotkb:PFKL(gene name)|psi-mi:PFKL(display_short)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme B(gene name synonym)|uniprotkb:6-phosphofructokinase type B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002021.2|refseq:NP_002617.3|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P17858|reactome:R-HSA-6798695|reactome:R-HSA-70171|ensembl:ENSG00000141959(gene)|ensembl:ENST00000349048(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lP9/V5WcCl5rLpy4QEZnWkLCCcQ9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61221	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06748	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78579|uniprotkb:P08693|uniprotkb:Q12826|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q14115|uniprotkb:Q5EU94|uniprotkb:Q5EU95|uniprotkb:Q5EU96|uniprotkb:Q5EU97|uniprotkb:Q5EU98|uniprotkb:Q5EU99|uniprotkb:Q6V962|uniprotkb:Q8WTW5|uniprotkb:Q96AT6|uniprotkb:Q96DC4|uniprotkb:Q96EA5|uniprotkb:A8K3N7|uniprotkb:B5BU00|uniprotkb:Q9UDJ7|uniprotkb:D3DQL6|uniprotkb:Q9BYG9|ensembl:ENSP00000296930|ensembl:ENSP00000428755	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:npm_human(display_long)|uniprotkb:NPM1(gene name)|psi-mi:NPM1(display_short)|uniprotkb:NPM(gene name synonym)|uniprotkb:Nucleolar phosphoprotein B23(gene name synonym)|uniprotkb:Numatrin(gene name synonym)|uniprotkb:Nucleolar protein NO38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002511.1|refseq:NP_954654.1|refseq:NP_001032827.1|dip:DIP-30932N|ensembl:ENSG00000181163(gene)|ensembl:ENST00000296930(transcript)|ensembl:ENST00000517671(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001652"(granular component)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019843"(rRNA binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042255"(ribosome assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060699"(regulation of endoribonuclease activity)|go:"GO:0060735"(regulation of eIF2 alpha phosphorylation by dsRNA)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902629"(regulation of mRNA stability involved in cellular response to UV)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR032569|interpro:IPR036824|mint:P06748|rcsb pdb:2LLH|rcsb pdb:2P1B|rcsb pdb:2VXD|rcsb pdb:5EHD|reactome:R-HSA-180746|reactome:R-HSA-3899300|reactome:R-HSA-606279|reactome:R-HSA-6804115|reactome:R-HSA-8869496	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HJ7Mg+XsIhuJiScPKiI0dIa6KpM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26038	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-528768|ensembl:ENSP00000353408	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13263	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12270	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048528|uniprotkb:Q15655|uniprotkb:Q99968|uniprotkb:Q5SWY0|intact:EBI-2555905|uniprotkb:Q15624|intact:EBI-28974527|ensembl:ENSP00000356448	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tpr_human(display_long)|uniprotkb:TPR(gene name)|psi-mi:TPR(display_short)|uniprotkb:Megator(gene name synonym)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000356448|ensembl:ENST00000613151|ensembl:ENSP00000483425|refseq:NP_003283.2|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|rcsb pdb:5TO5|rcsb pdb:5TO6|rcsb pdb:5TO7|rcsb pdb:5TVB|reactome:R-HSA-1169408|reactome:R-HSA-159227|ensembl:ENSG00000047410(gene)|ensembl:ENST00000367478(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|dip:DIP-50405N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vgoHzJI4cSOfqPSDoy+E067AdoI9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8WXE9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-539742|uniprotkb:Q6NT47|uniprotkb:Q96RI7|uniprotkb:Q96RU6|uniprotkb:Q17R24|uniprotkb:G3V2T7|uniprotkb:Q59H11|intact:EBI-28967360	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ston2_human(display_long)|uniprotkb:Stoned B(gene name synonym)|uniprotkb:STON2(gene name)|psi-mi:STON2(display_short)|uniprotkb:STNB(gene name synonym)|uniprotkb:STN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR017110(Stonin)|ensembl:ENST00000555447|ensembl:ENSP00000450857|ensembl:ENSG00000140022|ensembl:ENST00000614646|ensembl:ENSP00000477736|interpro:IPR028565|refseq:NP_149095.2|interpro:IPR012320(Stonin homology)|interpro:IPR022699|interpro:IPR036168|interpro:IPR031228|refseq:NP_001243359.1|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043005"(neuron projection)|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048488"(synaptic vesicle endocytosis)|rcsb pdb:2JXC|mint:Q8WXE9	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AtPNlh4TC/kL9DnGQJqv1BVwQCM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P84085	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-4289908|uniprotkb:P26437|ensembl:ENSP00000000233	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arf5_human(display_long)|uniprotkb:ARF5(gene name)|psi-mi:ARF5(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000004059(gene)|ensembl:ENST00000000233(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84085|rcsb pdb:2B6H|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001653.1|dip:DIP-61289N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62249	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352480|uniprotkb:P17008|uniprotkb:B2RDD5|ensembl:ENSP00000251453	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs16_human(display_long)|uniprotkb:RPS16(gene name)|psi-mi:RPS16(display_short)|uniprotkb:Small ribosomal subunit protein uS9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001011.1|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000105193(gene)|ensembl:ENST00000251453(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097421"(liver regeneration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P62249|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|dip:DIP-33200N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:OrKriR6HsATLaO+drdUa2w3Gpd09606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75369	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352089|intact:EBI-1754974|uniprotkb:Q13706|uniprotkb:Q59EC2|uniprotkb:Q6MZJ1|uniprotkb:Q8WXS9|uniprotkb:Q8WXT0|uniprotkb:Q8WXT1|uniprotkb:Q8WXT2|uniprotkb:Q9NRB5|uniprotkb:B2ZZ84|uniprotkb:Q9NT26|uniprotkb:Q9UEV9|intact:EBI-1960054|uniprotkb:C9JKE6|uniprotkb:B2ZZ85|uniprotkb:C9JMC4|ensembl:ENSP00000295956|uniprotkb:B2ZZ83|uniprotkb:Q60FE7|uniprotkb:Q8WXT3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flnb_human(display_long)|uniprotkb:FLNB(gene name)|psi-mi:FLNB(display_short)|uniprotkb:FLN1L(gene name synonym)|uniprotkb:FLN3(gene name synonym)|uniprotkb:TABP(gene name synonym)|uniprotkb:TAP(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Thyroid autoantigen(gene name synonym)|uniprotkb:Truncated actin-binding protein(gene name synonym)|uniprotkb:ABP-280 homolog(gene name synonym)|uniprotkb:ABP-278(gene name synonym)|uniprotkb:Filamin-3(gene name synonym)|uniprotkb:Filamin homolog 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001157791.1|refseq:NP_001448.2|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:O75369|rcsb pdb:2DI8|rcsb pdb:2DI9|rcsb pdb:2DIA|rcsb pdb:2DIB|rcsb pdb:2DIC|rcsb pdb:2DJ4|rcsb pdb:2DLG|rcsb pdb:2DMB|rcsb pdb:2DMC|rcsb pdb:2E9I|rcsb pdb:2E9J|rcsb pdb:2EE6|rcsb pdb:2EE9|rcsb pdb:2EEA|rcsb pdb:2EEB|rcsb pdb:2EEC|rcsb pdb:2EED|rcsb pdb:2WA5|rcsb pdb:2WA6|rcsb pdb:2WA7|rcsb pdb:3FER|rcsb pdb:4B7L|rcsb pdb:5DCP|reactome:R-HSA-1169408|ensembl:ENSG00000136068(gene)|ensembl:ENST00000295956(transcript)|go:"GO:0001725"(stress fiber)|refseq:NP_001157789.1|refseq:NP_001157790.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lsf6C/Vg0io7UhUi1Kapgwp0p5E9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30626	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750459|uniprotkb:D6W5Q0|intact:EBI-2623494|uniprotkb:A8MTH6|uniprotkb:B4DKK2|ensembl:ENSP00000265729	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sorcn_human(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_944490.1|refseq:NP_003121.1|refseq:NP_001243820.1|refseq:NP_001243821.1|dip:DIP-40970N|ensembl:ENSG00000075142(gene)|ensembl:ENST00000265729(transcript)|go:"GO:0001508"(action potential)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0030315"(T-tubule)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|rcsb pdb:2JC2|rcsb pdb:4U8D|rcsb pdb:4UPG|rcsb pdb:4USL|rcsb pdb:5MRA|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P30626|rcsb pdb:1JUO	-	-	crc64:A4829C7650A5E3FA	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:upE31IMimaotkgnYa7HYr7EYAxc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62241	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351811|uniprotkb:Q6IRL7|uniprotkb:P09058|ensembl:ENSP00000379888	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs8_human(display_long)|uniprotkb:RPS8(gene name)|psi-mi:RPS8(display_short)|uniprotkb:Small ribosomal subunit protein eS8(gene name synonym)|uniprotkb:OK/SW-cl.83(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001003.1|ensembl:ENSG00000142937(gene)|ensembl:ENST00000396651(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001047(Ribosomal protein S8e)|interpro:IPR018283|interpro:IPR022309|interpro:IPR042563|mint:P62241|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:6G5H|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975957|reactome:R-HSA-975956	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3rpCBdQyRWR+TCKnupbnCp30jKE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14979	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-299727|ensembl:ENSP00000295470|ensembl:ENSP00000422040|ensembl:ENSP00000483254|uniprotkb:Q6SPF2|uniprotkb:Q7KZ74|uniprotkb:Q7KZ75|uniprotkb:Q96IM0|uniprotkb:Q96S43	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrdl_human(display_long)|uniprotkb:HNRNPDL(gene name)|psi-mi:HNRNPDL(display_short)|uniprotkb:AU-rich element RNA-binding factor(gene name synonym)|uniprotkb:HNRPDL(gene name synonym)|uniprotkb:JKT41-binding protein(gene name synonym)|uniprotkb:JKTBP(gene name synonym)|uniprotkb:Protein laAUF1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000152795(gene)|ensembl:ENST00000295470(transcript)|ensembl:ENST00000502762(transcript)|ensembl:ENST00000621267(transcript)|go:"GO:0003677"(DNA binding)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034847|interpro:IPR035979|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|mint:O14979|go:"GO:0003723"(RNA binding)|reactome:R-HSA-8950505|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034046"("poly(G) binding")|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001193929.1|refseq:NP_112740.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:oOnEEar8AtKO5G6ldehucaRr4kM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55196	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-365875|uniprotkb:O75089|uniprotkb:Q5TIG6|uniprotkb:O75087|uniprotkb:O75088|uniprotkb:Q9NSN7|uniprotkb:Q9NU92|uniprotkb:Q5TIG7|uniprotkb:Q59FP0|ensembl:ENSP00000404595	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:afad_human(display_long)|uniprotkb:AFDN(gene name)|psi-mi:AFDN(display_short)|uniprotkb:AF6(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 6 protein(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:MLLT4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001035089.1|refseq:NP_001193937.1|refseq:XP_005267053.1|ensembl:ENST00000392108|ensembl:ENSP00000375956|ensembl:ENST00000392112|ensembl:ENSP00000375960|ensembl:ENST00000400822|ensembl:ENSP00000383623|ensembl:ENSP00000404595|refseq:NP_001278893.1|ensembl:ENSG00000130396(gene)|ensembl:ENST00000447894(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|interpro:IPR036034|interpro:IPR037977|mint:P55196|rcsb pdb:1T2M|rcsb pdb:1XZ9|rcsb pdb:2AIN|rcsb pdb:2EXG|rcsb pdb:5A6C|reactome:R-HSA-418990|go:"GO:0022409"(positive regulation of cell-cell adhesion)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x7kK5K1+wAFZFdVopvQ/l496J5U9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5T4S7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1995940|intact:EBI-1059327|uniprotkb:A8MPT2|uniprotkb:A8MQ33|uniprotkb:A8MQB1|uniprotkb:O60646|uniprotkb:O75050|uniprotkb:Q4QRK5|uniprotkb:Q5T4S8|uniprotkb:Q5T4S9|uniprotkb:Q5TBN8|uniprotkb:Q5TBP2|uniprotkb:Q6DKH8|uniprotkb:Q6P4A4|uniprotkb:Q7L8P7|uniprotkb:Q8IXJ4|uniprotkb:Q8TDN5|uniprotkb:Q8WV67|uniprotkb:Q9HA46|uniprotkb:Q9P2N9|uniprotkb:Q9UG82|ensembl:ENSP00000364403	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubr4_human(display_long)|uniprotkb:UBR4(gene name)|psi-mi:UBR4(display_short)|uniprotkb:KIAA0462(gene name synonym)|uniprotkb:KIAA1307(gene name synonym)|uniprotkb:RBAF600(gene name synonym)|uniprotkb:ZUBR1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:Retinoblastoma-associated factor of 600 kDa(gene name synonym)|uniprotkb:600 kDa retinoblastoma protein-associated factor(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_065816.2|ensembl:ENST00000375218|ensembl:ENSP00000364403|ensembl:ENSP00000364366|ensembl:ENSG00000127481(gene)|ensembl:ENST00000375254(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:Q5T4S7|reactome:R-HSA-6798695|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Iown8oj965YAir+95+3om5+1YM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BUL8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3U8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1057689|uniprotkb:Q6FIG1|uniprotkb:Q9UQF6|uniprotkb:B2R4Y1|uniprotkb:D6W634|ensembl:ENSP00000252543|ensembl:ENSP00000378081|ensembl:ENSP00000462609|ensembl:ENSP00000464342	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl36_human(display_long)|uniprotkb:RPL36(gene name)|psi-mi:RPL36(display_short)|uniprotkb:Large ribosomal subunit protein eL36(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056229.2|refseq:NP_378669.1|reactome:R-HSA-975957|mint:Q9Y3U8|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|interpro:IPR038097|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|rcsb pdb:6Y6X|ensembl:ENSG00000130255(gene)|ensembl:ENST00000347512(transcript)|ensembl:ENST00000394580(transcript)|ensembl:ENST00000577222(transcript)|ensembl:ENST00000579649(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000509(Ribosomal protein L36e)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:lRlRMF2jV/UHr4SX95SSCFIEV+s9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60468	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04264	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-298429|uniprotkb:Q14720|uniprotkb:Q6GSJ0|uniprotkb:B2RA01|uniprotkb:Q9H298|ensembl:ENSP00000252244|uniprotkb:P85925|uniprotkb:P86104	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k2c1_human(display_long)|uniprotkb:KRT1(gene name)|psi-mi:KRT1(display_short)|uniprotkb:KRTA(gene name synonym)|uniprotkb:Keratin-1(gene name synonym)|uniprotkb:Cytokeratin-1(gene name synonym)|uniprotkb:67 kDa cytokeratin(gene name synonym)|uniprotkb:Hair alpha protein(gene name synonym)|uniprotkb:Type-II keratin Kb1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006112.3|ensembl:ENSG00000167768(gene)|ensembl:ENST00000252244(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045095"(keratin filament)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR032449|interpro:IPR039008|mint:P04264|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6UUI|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TeAC3i2hWTS2lgXT0i4agp9nv349606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P33991	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P12829	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1222789|uniprotkb:P11783|uniprotkb:D3DXJ7|ensembl:ENSP00000347055|ensembl:ENSP00000377096|ensembl:ENSP00000461570	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myl4_human(display_long)|uniprotkb:MYL4(gene name)|psi-mi:MYL4(display_short)|uniprotkb:MLC1(gene name synonym)|uniprotkb:PRO1957(orf name)|uniprotkb:Myosin light chain 1, embryonic muscle/atrial isoform(gene name synonym)|uniprotkb:Myosin light chain alkali GT-1 isoform(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002841.1|refseq:NP_002467.1|refseq:XP_005257448.1|ensembl:ENSG00000198336(gene)|ensembl:ENST00000354968(transcript)|ensembl:ENST00000393450(transcript)|ensembl:ENST00000572316(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0016459"(myosin complex)|go:"GO:0031672"(A band)|go:"GO:0032038"(myosin II heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|reactome:R-HSA-390522	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:uoEY8vvAP2xDNz2TaBNrnxKFSGI9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49411	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359097|uniprotkb:O15276|ensembl:ENSP00000322439	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eftu_human(display_long)|uniprotkb:TUFM(gene name)|psi-mi:TUFM(display_short)|uniprotkb:P43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003312.3|ensembl:ENSG00000178952(gene)|ensembl:ENST00000313511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004541(Translation elongation factor EFTu/EF1A, bacterial and organelle)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|interpro:IPR033720|interpro:IPR041709|mint:P49411|rcsb pdb:7A5G|rcsb pdb:7O9K|reactome:R-HSA-5389840|refseq:XP_016879108.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pDRPUBUqvFqnh613N8bDTl4sFHc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BXJ9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1042540|uniprotkb:Q52LG9|uniprotkb:Q8IWH4|uniprotkb:Q8NEV2|uniprotkb:Q9H8P6|uniprotkb:D3DNY6|ensembl:ENSP00000296543	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:naa15_human(display_long)|uniprotkb:NAA15(gene name)|psi-mi:NAA15(display_short)|uniprotkb:GA19(gene name synonym)|uniprotkb:NATH(gene name synonym)|uniprotkb:TBDN100(gene name synonym)|uniprotkb:Gastric cancer antigen Ga19(gene name synonym)|uniprotkb:N-terminal acetyltransferase(gene name synonym)|uniprotkb:Protein tubedown-1(gene name synonym)|uniprotkb:Tbdn100(gene name synonym)|uniprotkb:NARG1(gene name synonym)|uniprotkb:NMDA receptor-regulated protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_476516.1|go:"GO:0016604"(nuclear body)|go:"GO:0017196"(N-terminal peptidyl-methionine acetylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031415"(NatA complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR021183|mint:Q9BXJ9|rcsb pdb:6C95|rcsb pdb:6C9M|rcsb pdb:6PPL|rcsb pdb:6PW9|ensembl:ENSG00000164134(gene)|ensembl:ENST00000296543(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006474"(N-terminal protein amino acid acetylation)|go:"GO:0016020"(membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BGW5jQRBYXuf75thzj6cWvL2A5Y9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H3K6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1642537|uniprotkb:A1L454|uniprotkb:A7YDY3|ensembl:ENSP00000331127|ensembl:ENSP00000498355	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:bola2_human(display_long)|uniprotkb:BOLA2(gene name)|psi-mi:BOLA2(display_short)|uniprotkb:BOLA2B(gene name)|psi-mi:BOLA2B(display_short)|uniprotkb:BOLA2A(gene name synonym)|uniprotkb:My016(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001026997.1|refseq:NP_001034271.1|refseq:NP_001307508.1|refseq:XP_016855107.1|ensembl:ENSG00000169627(gene)|ensembl:ENSG00000183336(gene)|ensembl:ENST00000330978(transcript)|ensembl:ENST00000651894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR002634(BolA-like protein)|interpro:IPR036065|mint:Q9H3K6|reactome:R-HSA-8950505	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5TcFdmQcwx5trexmXkWp9Arn5zE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43447	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46783	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354442|uniprotkb:Q5TZC0|uniprotkb:B2R4E3|ensembl:ENSP00000481646|ensembl:ENSP00000494190|ensembl:ENSP00000494440|ensembl:ENSP00000497917	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs10_human(display_long)|uniprotkb:RPS10(gene name)|psi-mi:RPS10(display_short)|uniprotkb:Small ribosomal subunit protein eS10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001005.1|refseq:NP_001190174.1|refseq:NP_001191020.1|ensembl:ENSG00000124614(gene)|ensembl:ENST00000464218(transcript)|ensembl:ENST00000467531(transcript)|ensembl:ENST00000621356(transcript)|ensembl:ENST00000648437(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR005326(Plectin/S10, N-terminal)|rcsb pdb:6G51|interpro:IPR036388|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|interpro:IPR037447|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|mint:P46783|rcsb pdb:4UG0|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:4V6X|rcsb pdb:6ZUO|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|rcsb pdb:5T2C|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:GWUAJh7s0w/ar/SOpx0hiIJOr2c9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16181	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2009373|uniprotkb:Q52M76|uniprotkb:Q6NX50|ensembl:ENSP00000381992	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sept7_human(display_long)|uniprotkb:SEPTIN7(gene name)|psi-mi:SEPTIN7(display_short)|uniprotkb:CDC10(gene name synonym)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:SEPT7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001779.3|dip:DIP-47093N|ensembl:ENSG00000122545(gene)|ensembl:ENST00000399034(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR008115(Septin 7)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:2QAG|rcsb pdb:3T5D|rcsb pdb:3TW4|rcsb pdb:6N0B|rcsb pdb:6N12|rcsb pdb:6UQQ|reactome:R-HSA-5687128	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CweIjGLXC7eubvKR7vkkihEkcHg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49588	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709710|uniprotkb:A6NF14|uniprotkb:Q53GV7|uniprotkb:Q96FA0|uniprotkb:B4DR45|ensembl:ENSP00000261772|ensembl:ENSP00000501924|ensembl:ENSP00000502247|ensembl:ENSP00000502797	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syac_human(display_long)|uniprotkb:AARS1(gene name)|psi-mi:AARS1(display_short)|uniprotkb:AARS(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-42(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001596.2|ensembl:ENSG00000090861(gene)|ensembl:ENST00000261772(transcript)|ensembl:ENST00000674691(transcript)|ensembl:ENST00000674963(transcript)|ensembl:ENST00000675643(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016597"(amino acid binding)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140018"(regulation of cytoplasmic translational fidelity)|interpro:IPR002318(Alanyl-tRNA synthetase, class IIc)|interpro:IPR003156(Phosphoesterase, DHHA1)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018162|interpro:IPR018163|interpro:IPR018164|interpro:IPR018165|interpro:IPR023033|mint:P49588|rcsb pdb:4XEM|rcsb pdb:4XEO|rcsb pdb:5KNN|rcsb pdb:5T5S|rcsb pdb:5T76|rcsb pdb:5V59|reactome:R-HSA-379716	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e9+gLroLXvK8li0wiPBGbZhQqP49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27635	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352398|uniprotkb:A3KQT0|uniprotkb:Q16470|uniprotkb:Q2HXT7|uniprotkb:Q53FH7|uniprotkb:Q6FGN8|uniprotkb:Q8TDA5|intact:EBI-3046680|uniprotkb:D3DWW6|ensembl:ENSP00000341730|ensembl:ENSP00000358832	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl10_human(display_long)|uniprotkb:RPL10(gene name)|psi-mi:RPL10(display_short)|uniprotkb:QM(gene name synonym)|uniprotkb:Protein QM(gene name synonym)|uniprotkb:Tumor suppressor QM(gene name synonym)|uniprotkb:Laminin receptor homolog(gene name synonym)|uniprotkb:DXS648E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL16(gene name synonym)|uniprotkb:Ribosomal protein L10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243506.2|refseq:NP_001243509.2|refseq:NP_001290553.1|refseq:NP_001290554.1|refseq:NP_001290555.1|ensembl:ENSG00000147403(gene)|ensembl:ENST00000344746(transcript)|ensembl:ENST00000369817(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|refseq:NP_006004.3|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001197(Ribosomal protein L10e)|interpro:IPR016180(Ribosomal protein L10e/L16)|interpro:IPR018255|interpro:IPR036920|mint:P27635|rcsb pdb:2PA2|rcsb pdb:5AJ0|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6W6L|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|go:"GO:0016020"(membrane)|reactome:R-HSA-975957|dip:DIP-1133N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wJnBcv39yvVz2CaZq8UKgxIpJeE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05388	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354101|uniprotkb:Q9BVK4|intact:EBI-8012155|intact:MINT-8395053|uniprotkb:Q3B7A4|ensembl:ENSP00000339027|ensembl:ENSP00000376299|ensembl:ENSP00000449328	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rla0_human(display_long)|uniprotkb:RPLP0(gene name)|psi-mi:RPLP0(display_short)|uniprotkb:60S ribosomal protein L10E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000993.1|refseq:NP_444505.1|ensembl:ENSG00000089157(gene)|ensembl:ENST00000228306(transcript)|ensembl:ENST00000392514(transcript)|ensembl:ENST00000551150(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0098794"(postsynapse)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR030670|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:P05388|rcsb pdb:4V6W|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8950505|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:xv3QHqnXxvCd3BOIeHVkqEnSNNk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P19623	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056183|uniprotkb:Q15511|uniprotkb:B1AKP9|ensembl:ENSP00000366156	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:spee_human(display_long)|uniprotkb:SRM(gene name)|psi-mi:SRM(display_short)|uniprotkb:SPS1(gene name synonym)|uniprotkb:SRML1(gene name synonym)|uniprotkb:Putrescine aminopropyltransferase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003123.2|ensembl:ENSG00000116649(gene)|ensembl:ENST00000376957(transcript)|go:"GO:0004766"(spermidine synthase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0006596"(polyamine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001045(Spermine synthase)|interpro:IPR029063|interpro:IPR030373|interpro:IPR030374|interpro:IPR030668|interpro:IPR035246|interpro:IPR037163|rcsb pdb:2O05|rcsb pdb:2O06|rcsb pdb:2O07|rcsb pdb:2O0L|rcsb pdb:3RW9|reactome:R-HSA-351202	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:VNjR3N2SwRzXIokl23Lis1pV3Pg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5JXB2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190823|uniprotkb:E9KL27	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ue2nl_human(display_long)|uniprotkb:Epididymis tissue protein Li 174(gene name synonym)|uniprotkb:UBE2NL(gene name)|psi-mi:UBE2NL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005634"(nucleus)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0000209"(protein polyubiquitination)|refseq:NP_001013007.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sh3UsocorMe1c+Y1g5ZEhvrblEk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y490	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35580	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92688	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36578	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348313|ensembl:ENSP00000311430|uniprotkb:P39029|uniprotkb:Q4VBR0|uniprotkb:Q969Z9|uniprotkb:A8K502	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl4_human(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:RPL1(gene name synonym)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000174444(gene)|ensembl:ENST00000307961(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR025755|mint:P36578|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|interpro:IPR023574|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OM0|refseq:NP_000959.2|dip:DIP-27559N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:34il/jyrW0Dqj0eA8GBFgUk05XU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UKM9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-714796|uniprotkb:Q14621|uniprotkb:Q2M365|uniprotkb:Q5QPL8|uniprotkb:Q9BQX6|uniprotkb:Q9UJE3|ensembl:ENSP00000246194	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:raly_human(display_long)|uniprotkb:hnRNP associated with lethal yellow protein homolog(gene name synonym)|uniprotkb:Autoantigen p542(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein C-like 2(gene name synonym)|uniprotkb:RALY(gene name)|psi-mi:RALY(display_short)|uniprotkb:P542(gene name synonym)|uniprotkb:HNRPCL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:XP_011526996.1|refseq:XP_011526997.1|ensembl:ENSG00000125970(gene)|ensembl:ENST00000246194(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR034502|interpro:IPR035979|mint:Q9UKM9|rcsb pdb:1WF1|refseq:NP_031393.2|refseq:NP_057951.1|refseq:XP_005260391.1|refseq:XP_005260393.1|refseq:XP_016883220.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3hd0n2UW0FSRNvSJa2mqflVeorc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75340	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352915|uniprotkb:E7ESR3|uniprotkb:Q5TZS0|uniprotkb:B2RD16|uniprotkb:Q2YDC2|ensembl:ENSP00000264933	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pdcd6_human(display_long)|uniprotkb:PDCD6(gene name)|psi-mi:PDCD6(display_short)|uniprotkb:ALG2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O75340|rcsb pdb:2ZN8|rcsb pdb:2ZN9|rcsb pdb:2ZND|rcsb pdb:2ZNE|rcsb pdb:2ZRS|rcsb pdb:2ZRT|rcsb pdb:3AAJ|rcsb pdb:3AAK|rcsb pdb:3WXA|rcsb pdb:5GQQ|go:"GO:0046983"(protein dimerization activity)|refseq:NP_037364.1|refseq:NP_001254485.1|refseq:NP_001254486.1|refseq:NP_001254487.1|refseq:NP_001254488.1|ensembl:ENSG00000249915(gene)|ensembl:ENST00000264933(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|dip:DIP-33217N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qbNAx73X9TJNr0MVNcy7Q9qN3Hg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8N983	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1043145|ensembl:ENSP00000315364|uniprotkb:Q5JW06|uniprotkb:Q7Z719|uniprotkb:Q7Z7H6|uniprotkb:Q86XN1|uniprotkb:Q9BYC7|uniprotkb:B1AL09|uniprotkb:B1AL07|uniprotkb:B1AL10|intact:EBI-1047104|uniprotkb:D3DR71|uniprotkb:B1AL06|uniprotkb:C9J5Q3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rm43_human(display_long)|uniprotkb:Mitochondrial ribosomal protein bMRP36a(gene name synonym)|uniprotkb:MRPL43(gene name)|psi-mi:MRPL43(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL43(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|ensembl:ENSG00000055950(gene)|ensembl:ENST00000318325(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR036249|interpro:IPR039927|mint:Q8N983|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:7A5I|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|refseq:NP_789764.1|refseq:XP_006718098.1|refseq:NP_115488.2|refseq:NP_789762.1|refseq:NP_789763.1|refseq:NP_001295325.1|ensembl:ENST00000299179|ensembl:ENSP00000299179|ensembl:ENSP00000315364|ensembl:ENST00000318364|ensembl:ENSP00000315948|ensembl:ENST00000342071|ensembl:ENSP00000339844|ensembl:ENST00000370234|ensembl:ENSP00000359254|ensembl:ENST00000370236|ensembl:ENSP00000359256|ensembl:ENST00000370242|ensembl:ENSP00000359262|refseq:XP_005270288.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:p3wPkljBAhx4IwvXsvfXDaEvpag9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13895	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358049|uniprotkb:Q6P5W4|uniprotkb:Q86W44|uniprotkb:Q96IP8|ensembl:ENSP00000230340	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:byst_human(display_long)|uniprotkb:BYSL(gene name)|psi-mi:BYSL(display_short)|uniprotkb:ENP1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004044.3|dip:DIP-50092N|ensembl:ENSG00000112578(gene)|ensembl:ENST00000230340(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045177"(apical part of cell)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR007955(Bystin)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|reactome:R-HSA-6791226	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QdpF9XYm2gFc5ZodqaGvqTM6XNk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62917	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-438527|ensembl:ENSP00000262584|ensembl:ENSP00000378378|ensembl:ENSP00000433464|uniprotkb:P25120|uniprotkb:Q567Q7|uniprotkb:Q969V7|uniprotkb:Q9BWQ9|uniprotkb:A8K094|uniprotkb:D3DWN2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl8_human(display_long)|uniprotkb:RPL8(gene name)|psi-mi:RPL8(display_short)|uniprotkb:Large ribosomal subunit protein uL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:4CCN|rcsb pdb:4CCO|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4Y3O|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000161016(gene)|ensembl:ENST00000262584(transcript)|ensembl:ENST00000394920(transcript)|ensembl:ENST00000528957(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0098794"(postsynapse)|interpro:IPR002171(Ribosomal protein L2)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR014726(Ribosomal protein L2, domain 3)|interpro:IPR022666|interpro:IPR022669|interpro:IPR022671|interpro:IPR023672|mint:P62917|rcsb pdb:4CCM|refseq:NP_000964.1|refseq:NP_150644.1|refseq:NP_001304700.1|refseq:NP_001304711.1|dip:DIP-37967N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+b/ORzdCy/nqFLsKRV9VhIZgdjg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A6NKE1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190709|ensembl:ENSP00000362253	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:a6nke1_human(display_long)|uniprotkb:TRAPPC3(gene name)|psi-mi:TRAPPC3(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000054116(gene)|ensembl:ENST00000373159(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030008"(TRAPP complex)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR016721(TRAPP I complex, Bet3)|interpro:IPR024096|interpro:IPR007194("Transport protein particle (TRAPP) component, Bet3")	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:39R93986KCjktIWg8GOua2Ak/j89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14566	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35527	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356382|uniprotkb:O00109|uniprotkb:Q0IJ47|uniprotkb:Q14665|ensembl:ENSP00000246662	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c9_human(display_long)|uniprotkb:KRT9(gene name)|psi-mi:KRT9(display_short)|uniprotkb:Keratin-9(gene name synonym)|uniprotkb:Cytokeratin-9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000217.2|ensembl:ENSG00000171403(gene)|ensembl:ENST00000246662(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0043588"(skin development)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P35527|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:m4EXfxbK2t1/EmI04YODKTJ02Zw9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q08945	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353771|uniprotkb:Q5BJG8|ensembl:ENSP00000278412	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ssrp1_human(display_long)|uniprotkb:SSRP1(gene name)|psi-mi:SSRP1(display_short)|uniprotkb:FACT80(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SSRP1(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex 80 kDa subunit(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 80 kDa subunit(gene name synonym)|uniprotkb:Structure-specific recognition protein 1(gene name synonym)|uniprotkb:Recombination signal sequence recognition protein 1(gene name synonym)|uniprotkb:T160(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003137.1|ensembl:ENSG00000149136(gene)|ensembl:ENST00000278412(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035101"(FACT complex)|go:"GO:0042393"(histone binding)|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000969(Structure-specific recognition protein)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR024954|interpro:IPR035417|interpro:IPR036910|interpro:IPR038167|mint:Q08945|rcsb pdb:4IFS|rcsb pdb:5UMR|rcsb pdb:5UMS|rcsb pdb:5VWE|rcsb pdb:6L1E|rcsb pdb:6L1R|rcsb pdb:6L34|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|dip:DIP-169N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WmdGVZadHdcS6Nk9SI41xKm+OrU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049228|uniprotkb:P78493|uniprotkb:P78494|uniprotkb:Q15364|uniprotkb:Q15686|uniprotkb:Q15687|uniprotkb:Q15689|uniprotkb:Q99377|uniprotkb:Q9UE45|uniprotkb:Q9UE46|uniprotkb:Q9UE47|uniprotkb:Q9UE48|uniprotkb:Q9UFQ6|intact:EBI-3190943|uniprotkb:B3KUA3|ensembl:ENSP00000472998	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ru17_human(display_long)|uniprotkb:SNRNP70(gene name)|psi-mi:SNRNP70(display_short)|uniprotkb:RPU1(gene name synonym)|uniprotkb:U1AP1(gene name synonym)|uniprotkb:RNPU1Z(gene name synonym)|uniprotkb:SNRP70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003080.2|refseq:NP_001287998.1|ensembl:ENSG00000104852(gene)|ensembl:ENST00000598441(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005685"(U1 snRNP)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR022023|interpro:IPR034143|interpro:IPR035979|mint:P08621|rcsb pdb:2L5I|rcsb pdb:2L5J|rcsb pdb:3CW1|rcsb pdb:3PGW|rcsb pdb:4PJO|rcsb pdb:4PKD|rcsb pdb:6QX9|rcsb pdb:7B0Y|reactome:R-HSA-72163|dip:DIP-29406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/P72B69q5f0TX4vTr4GuRrtgiRM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P59998	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351872|uniprotkb:O15509|uniprotkb:C9JWM7|uniprotkb:E7ETI0|uniprotkb:Q6P0W5|uniprotkb:Q96QJ3|ensembl:ENSP00000380431|uniprotkb:F6TTL5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arpc4_human(display_long)|uniprotkb:ARPC4(gene name)|psi-mi:ARPC4(display_short)|uniprotkb:ARC20(gene name synonym)|uniprotkb:Arp2/3 complex 20 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001185709.1|refseq:NP_005709.1|ensembl:ENSG00000241553(gene)|ensembl:ENST00000397261(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045010"(actin nucleation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008384(ARP23 complex 20 kDa subunit)|interpro:IPR034666|mint:P59998|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|refseq:NP_001020130.1|refseq:NP_001020131.1|dip:DIP-33188N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Iqe60TWfO3QBVOY+fOqZd9JWfIE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15154	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52789	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-741469|uniprotkb:Q8WU87|uniprotkb:Q9UN82|ensembl:ENSP00000290573|uniprotkb:D6W5J2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hxk2_human(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Muscle form hexokinase(gene name synonym)|uniprotkb:HK2(gene name)|psi-mi:HK2(display_short)|uniprotkb:Hexokinase-B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|mint:P52789|rcsb pdb:2NZT|rcsb pdb:5HEX|rcsb pdb:5HFU|rcsb pdb:5HG1|reactome:R-HSA-70171|go:"GO:0008865"(fructokinase activity)|ensembl:ENSG00000159399(gene)|ensembl:ENST00000290573(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|refseq:NP_000180.2|dip:DIP-50110N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:99w5KbKmsqMoorQz/wot6z6t2WM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31948	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08559	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62851	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353054|ensembl:ENSP00000435096|ensembl:ENSP00000486392|uniprotkb:P25111|uniprotkb:B2R4M7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs25_human(display_long)|uniprotkb:RPS25(gene name)|psi-mi:RPS25(display_short)|uniprotkb:Small ribosomal subunit protein eS25(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000118181(gene)|ensembl:ENSG00000280831(gene)|ensembl:ENST00000527673(transcript)|ensembl:ENST00000628770(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004977(Ribosomal protein S25)|interpro:IPR036388|mint:P62851|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y0G|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:6ZXD|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|rcsb pdb:6ZXE|reactome:R-HSA-9010553|reactome:R-HSA-9633012|rcsb pdb:6ZXF|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|refseq:NP_001019.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7TqA4Q6+6VMzrzaUrACbwtJKfOM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P26196	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61225	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-750871|uniprotkb:P17964|uniprotkb:Q96EG5|uniprotkb:Q9CXG0|ensembl:ENSP00000319096	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rap2b_human(display_long)|uniprotkb:RAP2B(gene name)|psi-mi:RAP2B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002877.2|ensembl:ENSG00000181467(gene)|ensembl:ENST00000323534(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0035579"(specific granule membrane)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dFHHIYuDf3lTGSX0Nys6IE9ONvs9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46777	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358018|ensembl:ENSP00000359345|uniprotkb:Q53HH6|uniprotkb:Q9H3F4|uniprotkb:Q32LZ3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl5_human(display_long)|uniprotkb:RPL5(gene name)|psi-mi:RPL5(display_short)|uniprotkb:Large ribosomal subunit protein uL18(gene name synonym)|uniprotkb:MSTP030(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|ensembl:ENSG00000122406(gene)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|ensembl:ENST00000370321(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|refseq:NP_000960.2|dip:DIP-31152N|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|mint:P46777|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rs+zAc+IPrEqv7DHNcy2GIkQkfY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q16891	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62847	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354515|uniprotkb:P16632|uniprotkb:Q7Z3D1|uniprotkb:Q5T0P7|uniprotkb:Q5T0P8|uniprotkb:E7EPK6|ensembl:ENSP00000478869	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs24_human(display_long)|uniprotkb:RPS24(gene name)|psi-mi:RPS24(display_short)|uniprotkb:Small ribosomal subunit protein eS24(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001135757.1|refseq:NP_001017.1|refseq:NP_001135755.1|refseq:NP_148982.1|ensembl:ENSG00000138326(gene)|ensembl:ENST00000613865(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001976(Ribosomal protein S24e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR018098|mint:P62847|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6XA1|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:M/qkRxabHx9PFaOM7EwKDOOwu7Q9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48729	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1383726|uniprotkb:Q96HD2|uniprotkb:Q5U046|uniprotkb:Q5U047|uniprotkb:Q6FGA2|uniprotkb:Q4JJA0|uniprotkb:Q9UDK3|intact:EBI-11048253|uniprotkb:D3DQG0|uniprotkb:D3DQG1|uniprotkb:Q71TU5|ensembl:ENSP00000367074	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kc1a_human(display_long)|uniprotkb:CSNK1A1(gene name)|psi-mi:CSNK1A1(display_short)|uniprotkb:CK1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001020276.1|refseq:NP_001883.4|refseq:NP_001258670.1|refseq:NP_001258671.1|dip:DIP-40367N|ensembl:ENSG00000113712(gene)|ensembl:ENST00000377843(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904424"(regulation of GTP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48729|rcsb pdb:5FQD|rcsb pdb:6GZD|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5635838	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:2rG1/sMVnsRKUEWsLhLAyHvqPnY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3D9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054270|uniprotkb:Q96Q24|uniprotkb:Q9BWH8|uniprotkb:Q9P053|uniprotkb:B2R6V3|ensembl:ENSP00000320184	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rt23_human(display_long)|uniprotkb:MRPS23(gene name)|psi-mi:MRPS23(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS23(gene name synonym)|uniprotkb:CGI-138(orf name)|uniprotkb:HSPC329(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057154.2|ensembl:ENSG00000181610(gene)|ensembl:ENST00000313608(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0031965"(nuclear membrane)|interpro:IPR019520|interpro:IPR023611|mint:Q9Y3D9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6Iyu6KkT1Y0+n0LKWy5Gf0DkhHw9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05783	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297888|uniprotkb:Q53G38|uniprotkb:Q5U0N8|uniprotkb:Q9BW26|ensembl:ENSP00000373487|ensembl:ENSP00000373489	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c18_human(display_long)|uniprotkb:KRT18(gene name)|psi-mi:KRT18(display_short)|uniprotkb:CYK18(gene name synonym)|uniprotkb:Keratin-18(gene name synonym)|uniprotkb:PIG46(orf name)|uniprotkb:Cytokeratin-18(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 46 protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007049"(cell cycle)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009750"(response to fructose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0072497"(mesenchymal stem cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1902488"(cholangiocyte apoptotic process)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR027695|interpro:IPR039008|mint:P05783|reactome:R-HSA-6805567|reactome:R-HSA-6809371|ensembl:ENSG00000111057(gene)|ensembl:ENST00000388835(transcript)|ensembl:ENST00000388837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|refseq:NP_000215.1|refseq:NP_954657.1|dip:DIP-633N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:6rtLZxuG0CSGcsCHEmkRKFVDeyo9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9P0L0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11387	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876302|ensembl:ENSP00000354522|uniprotkb:Q15610|uniprotkb:Q5TFY3|uniprotkb:Q9UJN0|uniprotkb:O43256|uniprotkb:Q12855|uniprotkb:Q12856|uniprotkb:A8KA78|uniprotkb:E1P5W3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:top1_human(display_long)|uniprotkb:DNA topoisomerase I(gene name synonym)|uniprotkb:TOP1(gene name)|psi-mi:TOP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198900(gene)|ensembl:ENST00000361337(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0012501"(programmed cell death)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|refseq:NP_003277.1|dip:DIP-36356N|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202|mint:P11387|rcsb pdb:1A31|rcsb pdb:1A35|rcsb pdb:1A36|rcsb pdb:1EJ9|rcsb pdb:1K4S|rcsb pdb:1K4T|rcsb pdb:1LPQ|rcsb pdb:1NH3|rcsb pdb:1R49|rcsb pdb:1RR8|rcsb pdb:1RRJ|rcsb pdb:1SC7|rcsb pdb:1SEU|rcsb pdb:1T8I|rcsb pdb:1TL8|reactome:R-HSA-4615885	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kB+3PVybgNp2mtOmDa7x8sygFuU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P02786	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15942	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-444225|ensembl:ENSP00000324422|ensembl:ENSP00000494798|uniprotkb:Q6I9S4|uniprotkb:A4D2G6|uniprotkb:B4DQX7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:zyx_human(display_long)|uniprotkb:Zyxin-2(gene name synonym)|uniprotkb:ZYX(gene name)|psi-mi:ZYX(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000159840(gene)|ensembl:ENSG00000285443(gene)|ensembl:ENST00000322764(transcript)|ensembl:ENST00000646695(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001781(Zinc finger, LIM-type)|go:"GO:0043149"(stress fiber assembly)|refseq:NP_001010972.1|refseq:NP_003452.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4UC6NVZHDUrTy4sPhz7e7RpPwho9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52907	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355586|uniprotkb:Q53FQ6|uniprotkb:Q6FHD5|ensembl:ENSP00000263168	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:caza1_human(display_long)|uniprotkb:CAPZA1(gene name)|psi-mi:CAPZA1(display_short)|uniprotkb:CapZ alpha-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006126.1|ensembl:ENSG00000116489(gene)|ensembl:ENST00000263168(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P52907|rcsb pdb:1MQ1|rcsb pdb:1MWN|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-879415|reactome:R-HSA-8950505|reactome:R-HSA-9662360|reactome:R-HSA-983231	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:97S4WPtjgt4MDLoptRhQ2yH8UNE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B4DKZ6	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190845	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b4dkz6_human(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0000347"(THO complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|interpro:IPR032302|interpro:IPR021418|interpro:IPR021726|interpro:IPR040007	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:YylX+q+OBzcU2jw2I/I1tV+uRYU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95372	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-715999|uniprotkb:Q7Z4Z2|ensembl:ENSP00000363638	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lypa2_human(display_long)|uniprotkb:Lysophospholipase II(gene name synonym)|uniprotkb:LYPLA2(gene name)|psi-mi:LYPLA2(display_short)|uniprotkb:APT2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009191.1|ensembl:ENSG00000011009(gene)|ensembl:ENST00000374514(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007411"(axon guidance)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0045296"(cadherin binding)|go:"GO:0046464"(acylglycerol catabolic process)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905344"(prostaglandin catabolic process)|interpro:IPR003140(Phospholipase/carboxylesterase)|interpro:IPR029058|rcsb pdb:5SYN|rcsb pdb:6BJE|reactome:R-HSA-373760	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yJ0IGnOIc6UvuzuLdZb8WzlN9aY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30048	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748336|intact:EBI-10975142|uniprotkb:P35690|uniprotkb:Q0D2H1|uniprotkb:Q13776|uniprotkb:Q5T5V2|uniprotkb:Q96HK4|uniprotkb:B2R7Z0|uniprotkb:D3DRC9|uniprotkb:E9PH29|ensembl:ENSP00000298510	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx3_human(display_long)|uniprotkb:Peroxiredoxin-3(gene name synonym)|uniprotkb:Peroxiredoxin III(gene name synonym)|uniprotkb:Antioxidant protein 1(gene name synonym)|uniprotkb:Protein MER5 homolog(gene name synonym)|uniprotkb:HBC189(gene name synonym)|uniprotkb:PRDX3(gene name)|psi-mi:PRDX3(display_short)|uniprotkb:AOP1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001289201.1|refseq:NP_006784.1|ensembl:ENSG00000165672(gene)|ensembl:ENST00000298510(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008785"(alkyl hydroperoxide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:P30048|rcsb pdb:5JCG|rcsb pdb:5UCX|reactome:R-HSA-3299685|go:"GO:0005769"(early endosome)|dip:DIP-33600N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+J/zV8u0jGCSzTGXafxgecTv/149606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52597	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352986|ensembl:ENSP00000338477|ensembl:ENSP00000349573|ensembl:ENSP00000400433|ensembl:ENSP00000438061|ensembl:ENSP00000507787|ensembl:ENSP00000348345|uniprotkb:Q5T0N2|uniprotkb:Q96AU2|uniprotkb:B3KM84	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hnrpf_human(display_long)|uniprotkb:HNRNPF(gene name)|psi-mi:HNRNPF(display_short)|uniprotkb:HNRPF(gene name synonym)|uniprotkb:Nucleolin-like protein mcs94-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P52597|rcsb pdb:2HGL|rcsb pdb:2HGM|rcsb pdb:2HGN|rcsb pdb:2KFY|rcsb pdb:2KG0|rcsb pdb:2KG1|rcsb pdb:3TFY|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000169813(gene)|ensembl:ENST00000337970(transcript)|ensembl:ENST00000356053(transcript)|ensembl:ENST00000357065(transcript)|ensembl:ENST00000443950(transcript)|ensembl:ENST00000544000(transcript)|ensembl:ENST00000682386(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001091674.1|refseq:NP_001091675.1|refseq:NP_001091676.1|refseq:NP_001091677.1|refseq:NP_001091678.1|refseq:NP_004957.1|dip:DIP-33145N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pblzpldZOa5vlZ+zGQY9qyWCxaw9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P14618	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9UNQ2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-395738|uniprotkb:O76025|uniprotkb:Q9BU77|uniprotkb:Q9UES1|ensembl:ENSP00000199320	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dim1_human(display_long)|uniprotkb:DIMT1L(gene name synonym)|uniprotkb:DIM1 dimethyladenosine transferase 1 homolog(gene name synonym)|uniprotkb:DIM1 dimethyladenosine transferase 1-like(gene name synonym)|uniprotkb:HUSSY-05(orf name)|uniprotkb:"Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase"(gene name synonym)|uniprotkb:Probable 18S rRNA dimethylase(gene name synonym)|uniprotkb:DIMT1(gene name)|psi-mi:DIMT1(display_short)|uniprotkb:"Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055288.1|ensembl:ENSG00000086189(gene)|ensembl:ENST00000199320(transcript)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0031167"(rRNA methylation)|go:"GO:0052909"("18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity")|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR029063|mint:Q9UNQ2|rcsb pdb:1ZQ9|rcsb pdb:6W6C|rcsb pdb:6W6F|reactome:R-HSA-6790901|refseq:NP_001335005.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hx0FRrx+XTeoziOqfesiw4KL+wo9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62081	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354360|uniprotkb:Q6IPH1|uniprotkb:P23821|uniprotkb:P24818|uniprotkb:Q57Z92|ensembl:ENSP00000385018|ensembl:ENSP00000385286|ensembl:ENSP00000495273|ensembl:ENSP00000496654|ensembl:ENSP00000496757	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs7_human(display_long)|uniprotkb:RPS7(gene name)|psi-mi:RPS7(display_short)|uniprotkb:Small ribosomal subunit protein eS7(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002.1|ensembl:ENSG00000171863(gene)|ensembl:ENST00000403564(transcript)|ensembl:ENST00000406376(transcript)|ensembl:ENST00000462576(transcript)|ensembl:ENST00000645674(transcript)|ensembl:ENST00000646909(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000554(Ribosomal protein S7e)|mint:P62081|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6G4S	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:l4aG6I34lmzYhNapbdv2CAAwRwg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:F2Z393	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190784|ensembl:ENSP00000437098	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:f2z393_human(display_long)|uniprotkb:TALDO1(gene name)|psi-mi:TALDO1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000177156(gene)|ensembl:ENST00000528097(transcript)|go:"GO:0004801"(transaldolase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|interpro:IPR001585(Transaldolase)|interpro:IPR004730(Transaldolase AB)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR018225	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HsQeEQ7VSDjAj16nSteErpQ1F309606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04843	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q6PKG0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12905	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357925|uniprotkb:A6NDB0|uniprotkb:Q5SR10|uniprotkb:Q5SR11|uniprotkb:Q7L7R3|uniprotkb:Q9BWD4|uniprotkb:Q9P1N0|uniprotkb:B2R8G7|ensembl:ENSP00000355011	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ilf2_human(display_long)|uniprotkb:PRO3063(orf name)|uniprotkb:NF45(gene name synonym)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004506.2|refseq:NP_001254738.1|ensembl:ENSG00000143621(gene)|ensembl:ENST00000361891(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q12905|reactome:R-HSA-6798695	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40926	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96QK1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054634|uniprotkb:Q561W2|uniprotkb:Q9H016|uniprotkb:Q9H096|uniprotkb:Q9H4P3|uniprotkb:Q9H8J0|uniprotkb:Q9NRS7|uniprotkb:Q9NVG2|uniprotkb:Q9NX80|uniprotkb:Q9NZK2|ensembl:ENSP00000299138	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vps35_human(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:VPS35(gene name)|psi-mi:VPS35(display_short)|uniprotkb:MEM3(gene name synonym)|uniprotkb:TCCCTA00141(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_060676.2|rcsb pdb:5F0J|rcsb pdb:5F0K|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:7BLN|rcsb pdb:7BLO|reactome:R-HSA-3238698|ensembl:ENSG00000069329(gene)|ensembl:ENST00000299138(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097422"(tubular endosome)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|rcsb pdb:2R17|dip:DIP-29076N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:EXkMduDQKNCdp876vGF5vna9t389606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42356	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-723050|uniprotkb:Q7Z625|uniprotkb:Q9UPG2|ensembl:ENSP00000255882|intact:EBI-11053324	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pi4ka_human(display_long)|uniprotkb:PIK4CA(gene name synonym)|uniprotkb:PI4KA(gene name)|psi-mi:PI4KA(display_short)|uniprotkb:PIK4(gene name synonym)|uniprotkb:Phosphatidylinositol 4-Kinase III alpha(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000241973(gene)|ensembl:ENST00000255882(transcript)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR042236|rcsb pdb:6BQ1|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016301"(kinase activity)|refseq:NP_477352.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tm7wwZPJEvFMfK9xHMPLW9oYtzk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q02790	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P18206	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-716775|uniprotkb:Q16450|uniprotkb:Q5SWX2|uniprotkb:Q7Z3B8|uniprotkb:Q8IXU7|ensembl:ENSP00000211998	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vinc_human(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003364.1|refseq:NP_054706.1|ensembl:ENSG00000035403(gene)|ensembl:ENST00000211998(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P18206|rcsb pdb:1RKC|rcsb pdb:1RKE|rcsb pdb:1SYQ|rcsb pdb:1TR2|rcsb pdb:1YDI|rcsb pdb:2GWW|rcsb pdb:2HSQ|rcsb pdb:2IBF|rcsb pdb:3H2U|rcsb pdb:3H2V|rcsb pdb:3JBK|rcsb pdb:3MYI|rcsb pdb:3RF3|rcsb pdb:3S90|go:"GO:0005198"(structural molecule activity)|rcsb pdb:3TJ5|rcsb pdb:3TJ6|rcsb pdb:3VF0|rcsb pdb:4DJ9|rcsb pdb:4EHP|rcsb pdb:4LN2|rcsb pdb:4LNP|rcsb pdb:4PR9|rcsb pdb:5L0C|rcsb pdb:5L0D|rcsb pdb:5L0F|rcsb pdb:5L0G|rcsb pdb:5L0H|rcsb pdb:5L0I|rcsb pdb:5L0J|rcsb pdb:5O2Q|rcsb pdb:6FUY|rcsb pdb:6UPW|rcsb pdb:7KTT|rcsb pdb:7KTU|rcsb pdb:7KTV|rcsb pdb:7KTW|reactome:R-HSA-114608|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|ensembl:ENSP00000211998|ensembl:ENST00000372755|ensembl:ENSP00000361841|dip:DIP-35570N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Cs5ZD4u5mH3IHBeKWMRV4cfS+y49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28331-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190702|ensembl:ENSP00000392709|ensembl:ENSP00000490092	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p28331-2(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000455934(transcript)|ensembl:ENST00000637733(transcript)|intact:EBI-1043922(isoform-parent)|uniprotkb:P28331-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kKrRPFU4CRdHw5sNtWXMEoWgMEI9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P00491	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712238|ensembl:ENSP00000354532|uniprotkb:Q15160|uniprotkb:Q5PZ03|uniprotkb:B2R8S5|uniprotkb:D3DS00	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pnph_human(display_long)|uniprotkb:Inosine phosphorylase(gene name synonym)|uniprotkb:PNP(gene name)|psi-mi:PNP(display_short)|uniprotkb:NP(gene name synonym)|uniprotkb:Inosine-guanosine phosphorylase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001882"(nucleoside binding)|go:"GO:0002060"(purine nucleobase binding)|go:"GO:0004731"(purine-nucleoside phosphorylase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006148"(inosine catabolic process)|go:"GO:0006149"(deoxyinosine catabolic process)|go:"GO:0006157"(deoxyadenosine catabolic process)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006204"(IMP catabolic process)|go:"GO:0006738"(nicotinamide riboside catabolic process)|go:"GO:0006955"(immune response)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0019428"(allantoin biosynthetic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043101"(purine-containing compound salvage)|go:"GO:0046059"(dAMP catabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0047975"(guanosine phosphorylase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000845(Nucleoside phosphorylase)|interpro:IPR011268(Inosine guanosine and xanthosine phosphorylase)|interpro:IPR011270(Purine nucleoside phosphorylase I, inosine and guanosine-specific)|interpro:IPR018099|interpro:IPR035994|mint:P00491|rcsb pdb:1M73|rcsb pdb:1PF7|rcsb pdb:1PWY|rcsb pdb:1RCT|rcsb pdb:1RFG|rcsb pdb:1RR6|rcsb pdb:1RSZ|rcsb pdb:1RT9|rcsb pdb:1ULA|rcsb pdb:1ULB|rcsb pdb:1V2H|rcsb pdb:1V3Q|rcsb pdb:1V41|rcsb pdb:1V45|rcsb pdb:1YRY|rcsb pdb:2A0W|rcsb pdb:2A0X|rcsb pdb:2A0Y|rcsb pdb:2OC4|rcsb pdb:2OC9|rcsb pdb:2ON6|rcsb pdb:2Q7O|rcsb pdb:3BGS|rcsb pdb:3D1V|rcsb pdb:3GB9|rcsb pdb:3GGS|ensembl:ENSG00000198805(gene)|ensembl:ENST00000361505(transcript)|go:"GO:0000255"(allantoin metabolic process)|rcsb pdb:3K8O|rcsb pdb:3K8Q|rcsb pdb:3PHB|rcsb pdb:4EAR|rcsb pdb:3INY|rcsb pdb:4EB8|rcsb pdb:4ECE|rcsb pdb:4GKA|rcsb pdb:5ETJ|rcsb pdb:5UGF|reactome:R-HSA-6798695|reactome:R-HSA-74217|reactome:R-HSA-74259|refseq:NP_000261.2|dip:DIP-50406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FOpaxV/M6HIA+THugPZDfN1ej1o9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51148	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25788	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-348380|ensembl:ENSP00000216455|uniprotkb:Q86U83|uniprotkb:Q8N1D8|uniprotkb:Q9BS70|uniprotkb:B2RCK6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa3_human(display_long)|uniprotkb:PSMA3(gene name)|psi-mi:PSMA3(display_short)|uniprotkb:PSC8(gene name synonym)|uniprotkb:Proteasome component C8(gene name synonym)|uniprotkb:Macropain subunit C8(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C8(gene name synonym)|uniprotkb:HC8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002779.1|refseq:NP_687033.1|ensembl:ENSG00000100567(gene)|ensembl:ENST00000216455(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR037555|mint:P25788|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:5DSV|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|rcsb pdb:7E55|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:5T0H|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-174084|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-174113|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|dip:DIP-29366N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9Er/PY50/GVoCr5yAPXlkfxtP0k9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07900-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190772|ensembl:ENSP00000335153	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:p07900-2(display_long)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym)|uniprotkb:HSP90AA1-2(isoform synonym)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000080824(gene)|ensembl:ENST00000334701(transcript)|intact:EBI-296047(isoform-parent)|uniprotkb:P07900-2(isoform-parent)	-	-	isoform-comment:"Variant in position: 71:M->L (in dbSNP:rs8005905)."	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zSFsoTnWMCxMgg5CMgkY21uBpb89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q12906	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P05556	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46940	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q06124	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07355	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P51692	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15691	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1004115|uniprotkb:Q3KQS8|uniprotkb:B2R6I7|uniprotkb:E1P5M8|ensembl:ENSP00000364721	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mare1_human(display_long)|uniprotkb:APC-binding protein EB1(gene name synonym)|uniprotkb:End-binding protein 1(gene name synonym)|uniprotkb:MAPRE1(gene name)|psi-mi:MAPRE1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036457.1|refseq:XP_011526998.1|ensembl:ENSG00000101367(gene)|ensembl:ENST00000375571(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0016477"(cell migration)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:1903033"(positive regulation of microtubule plus-end binding)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:1904825"(protein localization to microtubule plus-end)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1905721"(mitotic spindle astral microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR004953(EB1, C-terminal)|interpro:IPR027328|interpro:IPR027739|interpro:IPR036133|interpro:IPR036872|mint:Q15691|rcsb pdb:1PA7|rcsb pdb:1TXQ|rcsb pdb:1UEG|rcsb pdb:1VKA|rcsb pdb:1WU9|rcsb pdb:1YIB|rcsb pdb:1YIG|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2QJZ|rcsb pdb:2R8U|rcsb pdb:3GJO|rcsb pdb:3MTU|rcsb pdb:3MUD|rcsb pdb:3TQ7|rcsb pdb:4XA1|rcsb pdb:4XA3|rcsb pdb:4XA6|rcsb pdb:5JV3|rcsb pdb:5JVM|rcsb pdb:5JVP|rcsb pdb:5JVR|rcsb pdb:5JVS|rcsb pdb:5JVU|rcsb pdb:5JX1|rcsb pdb:5WLQ|rcsb pdb:6PF2|rcsb pdb:6PFP|rcsb pdb:6YF5|rcsb pdb:6YSH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|dip:DIP-38018N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+JBCBM7dbbrxn6mX8RiwejYWJ2U9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50552	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q86UX7	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-373158|uniprotkb:Q8IUA1|uniprotkb:Q8N207|uniprotkb:Q9BT48|ensembl:ENSP00000279227	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:urp2_human(display_long)|uniprotkb:FERMT3(gene name)|psi-mi:FERMT3(display_short)|uniprotkb:KIND3(gene name synonym)|uniprotkb:MIG2B(gene name synonym)|uniprotkb:URP2(gene name synonym)|uniprotkb:Unc-112-related protein 2(gene name synonym)|uniprotkb:Kindlin-3(gene name synonym)|uniprotkb:MIG2-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_113659.3|refseq:NP_848537.1|refseq:XP_011543596.1|ensembl:ENSG00000149781(gene)|ensembl:ENST00000279227(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042995"(cell projection)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR037837|interpro:IPR037843|interpro:IPR040790|rcsb pdb:2YS3|rcsb pdb:6V97|rcsb pdb:6V9G|rcsb pdb:7C3M|reactome:R-HSA-114608|refseq:XP_016873887.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BDLaeBD6Ycz4HAh/4QlZeSZurxY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55769	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712228|ensembl:ENSP00000215956|ensembl:ENSP00000383949|ensembl:ENSP00000497142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nh2l1_human(display_long)|uniprotkb:SNU13(gene name)|psi-mi:SNU13(display_short)|uniprotkb:High mobility group-like nuclear protein 2 homolog 1(gene name synonym)|uniprotkb:NHP2L1(gene name synonym)|uniprotkb:OTK27(gene name synonym)|uniprotkb:SNU13 homolog(gene name synonym)|uniprotkb:U4/U6.U5 small nuclear ribonucleoprotein SNU13(gene name synonym)|uniprotkb:U4/U6.U5 tri-snRNP 15.5 kDa protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100138(gene)|ensembl:ENST00000215956(transcript)|ensembl:ENST00000401959(transcript)|ensembl:ENST00000648674(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0007338"(single fertilization)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051117"(ATPase binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P55769|rcsb pdb:1E7K|rcsb pdb:2JNB|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_001003796.1|refseq:NP_004999.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZMkqsDfMCrTlT/kJxillOA8839E9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P21796	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350581|uniprotkb:B2R4B3|ensembl:ENSP00000346015	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl27a_human(display_long)|uniprotkb:RPL27A(gene name)|psi-mi:RPL27A(display_short)|uniprotkb:Large ribosomal subunit protein uL15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000981.1|ensembl:ENSG00000166441(gene)|ensembl:ENST00000314138(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001196(Ribosomal protein L15)|interpro:IPR021131|interpro:IPR027386|interpro:IPR030878|interpro:IPR036227|mint:P46776|rcsb pdb:4BXF|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6IP6|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6OM7|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:6IP5|dip:DIP-33121N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tUezMQBw+SWmLYq8M0pkLCF8vO89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61224	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28066	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355475|uniprotkb:B4E2V4|uniprotkb:Q6IBF7|uniprotkb:Q3T1C1|uniprotkb:B2R8F6|ensembl:ENSP00000271308	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa5_human(display_long)|uniprotkb:PSMA5(gene name)|psi-mi:PSMA5(display_short)|uniprotkb:Proteasome zeta chain(gene name synonym)|uniprotkb:Macropain zeta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex zeta chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001186701.1|refseq:NP_001186702.1|refseq:NP_001186703.1|refseq:NP_002781.2|ensembl:ENSG00000143106(gene)|ensembl:ENST00000271308(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR033812|mint:P28066|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEY|rcsb pdb:5LEX|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29368N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:bfMG3npzVetUH1tahr2MAI4R+3g9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48444	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P47756	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353595|uniprotkb:Q5U0L4|uniprotkb:Q8TB49|uniprotkb:Q9NUC4|uniprotkb:Q32Q68|ensembl:ENSP00000364284|ensembl:ENSP00000501528	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:capzb_human(display_long)|uniprotkb:CAPZB(gene name)|psi-mi:CAPZB(display_short)|uniprotkb:CapZ beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001193469.1|refseq:NP_004921.1|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|mint:P47756|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-9013405|reactome:R-HSA-9035034|reactome:R-HSA-9662360|reactome:R-HSA-983231|ensembl:ENSG00000077549(gene)|ensembl:ENST00000375142(transcript)|ensembl:ENST00000674432(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030863"(cortical cytoskeleton)|refseq:NP_001269091.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:qRXsrB2fLT1DMVIVRWKFYe4Aln49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q96CW1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P15880	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-443446|ensembl:ENSP00000341885|uniprotkb:Q3MIB1|uniprotkb:B2R5G0|uniprotkb:D3DU82	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rs2_human(display_long)|uniprotkb:RPS2(gene name)|psi-mi:RPS2(display_short)|uniprotkb:RPS4(gene name synonym)|uniprotkb:40S ribosomal protein S4(gene name synonym)|uniprotkb:Protein LLRep3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|rcsb pdb:6OLG|rcsb pdb:6OLI|interpro:IPR018192|rcsb pdb:6OLZ|interpro:IPR020568|mint:P15880|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6EK0|rcsb pdb:6G18|rcsb pdb:6XA1|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6G5H|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7JQB|rcsb pdb:7JQC|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-3214858|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8876725|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:7A09|ensembl:ENSG00000140988(gene)|ensembl:ENST00000343262(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045296"(cadherin binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000851(Ribosomal protein S5)|interpro:IPR005324(Ribosomal protein S5, C-terminal)|interpro:IPR005711(Ribosomal protein S5, eukaryotic/archaeal)|interpro:IPR013810(Ribosomal protein S5, N-terminal)|refseq:NP_002943.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JUr2Y3cGk00S8KaTVPymshfaHhc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:A6NHR9	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2801919|uniprotkb:O75141|uniprotkb:Q6AHX6|uniprotkb:Q9H6Q2|uniprotkb:Q6ZTQ8|intact:EBI-3192385|uniprotkb:Q9UG39|ensembl:ENSP00000326603	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smhd1_human(display_long)|uniprotkb:KIAA0650(gene name synonym)|uniprotkb:SMCHD1(gene name)|psi-mi:SMCHD1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056110.2|ensembl:ENSG00000101596(gene)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR036277|interpro:IPR036890|interpro:IPR038892|mint:A6NHR9|rcsb pdb:6MW7|ensembl:ENST00000320876(transcript)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006302"(double-strand break repair)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043584"(nose development)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0060820"(inactivation of X chromosome by heterochromatin assembly)|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7tHwsz7p8pAqG9grnerpgMTmt3Q9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61026	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-726075|uniprotkb:O88386|uniprotkb:Q6IA52|uniprotkb:Q9D7X6|uniprotkb:Q9H0T3|uniprotkb:D6W538|ensembl:ENSP00000264710	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rab10_human(display_long)|uniprotkb:RAB10(gene name)|psi-mi:RAB10(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_057215.3|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:5LPN|rcsb pdb:5SZJ|reactome:R-HSA-1445148|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000084733(gene)|ensembl:ENST00000264710(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43707	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351526|uniprotkb:O76048|uniprotkb:D6PXK4|ensembl:ENSP00000252699|ensembl:ENSP00000489220|uniprotkb:A4K467	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:actn4_human(display_long)|uniprotkb:ACTN4(gene name)|psi-mi:ACTN4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004915.2|ensembl:ENSG00000130402(gene)|ensembl:ENSG00000282844(gene)|ensembl:ENST00000252699(transcript)|ensembl:ENST00000634960(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:O43707|rcsb pdb:1WLX|rcsb pdb:1YDI|rcsb pdb:2R0O|rcsb pdb:6O31|rcsb pdb:6OA6|reactome:R-HSA-114608|reactome:R-HSA-373753|dip:DIP-33179N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kTYezA2lEtL/AQPfCQ8BE79nzow9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09661	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876439|uniprotkb:Q8TBD2|uniprotkb:B2R5I6|ensembl:ENSP00000254193	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ru2a_human(display_long)|uniprotkb:SNRPA1(gene name)|psi-mi:SNRPA1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003081.2|dip:DIP-625N|ensembl:ENSG00000131876(gene)|ensembl:ENST00000254193(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR044640|mint:P09661|rcsb pdb:1A9N|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|reactome:R-HSA-8950505	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tmZyAPCvMg34GY4kVc6NcnycOeE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62633	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y266	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P55884	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35232	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46779	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-366357|uniprotkb:Q6IAY0|uniprotkb:Q96FX1|uniprotkb:Q9BWQ0|uniprotkb:B2R4A6|uniprotkb:B4DEP9|uniprotkb:E9PB24|uniprotkb:C9JB50|uniprotkb:G5E9L2|ensembl:ENSP00000342787|ensembl:ENSP00000453319	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl28_human(display_long)|uniprotkb:RPL28(gene name)|psi-mi:RPL28(display_short)|uniprotkb:Large ribosomal subunit protein eL28(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129608.1|refseq:NP_001129609.1|refseq:NP_000982.2|refseq:NP_001129606.1|refseq:NP_001129607.1|ensembl:ENSG00000108107(gene)|ensembl:ENST00000344063(transcript)|ensembl:ENST00000559463(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002672(Ribosomal protein L28e)|interpro:IPR029004|mint:P46779|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:I7Me1zjfxk98g6C2NoYOWlmrYVc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62318	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372789|uniprotkb:P43331|uniprotkb:B5BU13|uniprotkb:B4DJP7|ensembl:ENSP00000215829|intact:EBI-10981086	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:smd3_human(display_long)|uniprotkb:SNRPD3(gene name)|psi-mi:SNRPD3(display_short)|uniprotkb:snRNP core protein D3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004166.1|refseq:NP_001265585.1|ensembl:ENSG00000100028(gene)|ensembl:ENST00000215829(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:0071209"(U7 snRNA binding)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034099|mint:P62318|rcsb pdb:1D3B|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-111367|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-73856|reactome:R-HSA-77588|rcsb pdb:7ABG|rcsb pdb:3VRI|rcsb pdb:4PJO|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:3PGW|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6V4X|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|dip:DIP-31216N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:WkrSZVfVmSQrJYfy7mwp48xjsVA9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P54920	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-749652|uniprotkb:Q96IK3|uniprotkb:Q9BVJ3|uniprotkb:A8K879|ensembl:ENSP00000263354	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:snaa_human(display_long)|uniprotkb:N-ethylmaleimide-sensitive factor attachment protein alpha(gene name synonym)|uniprotkb:NAPA(gene name)|psi-mi:NAPA(display_short)|uniprotkb:SNAPA(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003818.2|ensembl:ENSG00000105402(gene)|ensembl:ENST00000263354(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005483"(soluble NSF attachment protein activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007420"(brain development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031201"(SNARE complex)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000744(NSF attachment protein)|interpro:IPR011990(Tetratricopeptide-like helical)|reactome:R-HSA-204005|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RHbBvhRSSaakY4HPkl3Y9ggkiPk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q92621	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1045046|uniprotkb:Q86YC1|uniprotkb:A6H8X3|ensembl:ENSP00000285968	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu205_human(display_long)|uniprotkb:Nucleoporin Nup205(gene name synonym)|uniprotkb:205 kDa nucleoporin(gene name synonym)|uniprotkb:NUP205(gene name)|psi-mi:NUP205(display_short)|uniprotkb:C7orf14(gene name synonym)|uniprotkb:KIAA0225(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000155561(gene)|ensembl:ENST00000285968(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|interpro:IPR021827|mint:Q92621|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:NP_055950.1|refseq:NP_001316363.1|dip:DIP-44021N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:5lulE2tOZ4V1UZPwkEvOo9reZWE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9BZL1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-607755|ensembl:ENSP00000351492|ensembl:ENSP00000466910|ensembl:ENSP00000468656|uniprotkb:Q2NL89	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ubl5_human(display_long)|uniprotkb:UBL5(gene name)|psi-mi:UBL5(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000198258(gene)|ensembl:ENST00000358666(transcript)|ensembl:ENST00000586895(transcript)|ensembl:ENST00000590068(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0031386"(protein tag)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039732|rcsb pdb:1P0R|rcsb pdb:4PYU|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:6AHD|refseq:NP_001041706.1|refseq:NP_077268.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:tm6rC2ylXI3og2IqNXSHmgi2f/09606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P07195	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00231	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BgQKXK7gMMihacRCI+g/pBnRN309606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y6I3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-713198|intact:EBI-28967658|ensembl:ENSP00000270460|uniprotkb:Q86ST3|uniprotkb:Q9HA18	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:epn1_human(display_long)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:EH domain-binding mitotic phosphoprotein(gene name synonym)|uniprotkb:EPN1(gene name)|psi-mi:EPN1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048568"(embryonic organ development)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q9Y6I3|rcsb pdb:1INZ|rcsb pdb:1KYD|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000063245(gene)|ensembl:ENST00000270460(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|ensembl:ENST00000085079|ensembl:ENSP00000085079|ensembl:ENSP00000270460|ensembl:ENST00000411543|ensembl:ENSP00000406209|refseq:NP_001123543.1|refseq:NP_001123544.1|refseq:NP_037465.2|refseq:XP_005258886.1|refseq:XP_016882211.1|refseq:XP_011525183.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mp6MIJYGUJryy3Lk5coFqvOt55c9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36776	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P39023	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1056348|uniprotkb:Q15548|uniprotkb:Q5I0G0|uniprotkb:B2RDV9|ensembl:ENSP00000346001	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl3_human(display_long)|uniprotkb:RPL3(gene name)|psi-mi:RPL3(display_short)|uniprotkb:HIV-1 TAR RNA-binding protein B(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL3(gene name synonym)|uniprotkb:OK/SW-cl.32(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000958.1|ensembl:ENSG00000100316(gene)|ensembl:ENST00000216146(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P39023|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:j3MVAYfO/bziJBPmH4zCFqFskZ89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04083	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-354007|ensembl:ENSP00000257497|ensembl:ENSP00000366109|uniprotkb:B5BU38	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anxa1_human(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:LPC1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000691.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|ensembl:ENSG00000135046(gene)|ensembl:ENST00000257497(transcript)|ensembl:ENST00000376911(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|refseq:XP_011516911.1|dip:DIP-32875N|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P04083|rcsb pdb:1AIN|rcsb pdb:1BO9|rcsb pdb:1QLS|rcsb pdb:5VFW|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-445355|reactome:R-HSA-6785807|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QKmqz+UsAof35B/so2qKLQjn2v09606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O95782	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353552|uniprotkb:Q96CI7|uniprotkb:Q96PP6|uniprotkb:Q96PP7|uniprotkb:Q9H070|intact:EBI-28973302|ensembl:ENSP00000351926	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2a1_human(display_long)|uniprotkb:AP2A1(gene name)|psi-mi:AP2A1(display_short)|uniprotkb:ADTAA(gene name synonym)|uniprotkb:CLAPA1(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_055018.2|refseq:NP_570603.2|ensembl:ENST00000354293|ensembl:ENSP00000346246|ensembl:ENSP00000351926|ensembl:ENSG00000196961(gene)|ensembl:ENST00000359032(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O95782|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|dip:DIP-33164N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:egkaIAhvIi1FqNr+8KEFeJaYZcc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P11166	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3F4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-727414|uniprotkb:Q9UQC8|uniprotkb:Q9NTK0|uniprotkb:Q5TZT4|intact:EBI-6190807|uniprotkb:B4DNJ6|uniprotkb:B2R5S5|ensembl:ENSP00000392270	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:strap_human(display_long)|uniprotkb:UNR-interacting protein(gene name synonym)|uniprotkb:WD-40 repeat protein PT-WD(gene name synonym)|uniprotkb:MAP activator with WD repeats(gene name synonym)|uniprotkb:STRAP(gene name)|psi-mi:STRAP(display_short)|uniprotkb:MAWD(gene name synonym)|uniprotkb:UNRIP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_009109.3|ensembl:ENSG00000023734(gene)|ensembl:ENST00000419869(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:Q9Y3F4|reactome:R-HSA-2173788	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/IqZt6BHPxD3S/THUZry4+QUvCE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14974	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P47897	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-347462|uniprotkb:B4DWJ2|ensembl:ENSP00000307567	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:syq_human(display_long)|uniprotkb:QARS1(gene name)|psi-mi:QARS1(display_short)|uniprotkb:Glutaminyl-tRNA synthetase(gene name synonym)|uniprotkb:QARS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005042.1|ensembl:ENSG00000172053(gene)|ensembl:ENST00000306125(transcript)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004514(Glutaminyl-tRNA synthetase, class Ic)|interpro:IPR007638(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 2)|interpro:IPR007639(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 1)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR042558|interpro:IPR042559|mint:P47897|rcsb pdb:4R3Z|rcsb pdb:4YE6|rcsb pdb:4YE8|rcsb pdb:4YE9|reactome:R-HSA-2408522|go:"GO:0006469"(negative regulation of protein kinase activity)|reactome:R-HSA-379716|reactome:R-HSA-379726|go:"GO:0007420"(brain development)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_001259002.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3Q8LR+aWJJue/ixtD3ZYDpC/D3o9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50402	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P52292	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-349938|uniprotkb:Q9BRU5|ensembl:ENSP00000504685|intact:EBI-28977049|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|uniprotkb:B9EJD6|uniprotkb:Q53YE3|intact:EBI-9377406|uniprotkb:Q6NVW7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ima1_human(display_long)|uniprotkb:KPNA2(gene name)|psi-mi:KPNA2(display_short)|uniprotkb:RCH1(gene name synonym)|uniprotkb:SRP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002257.1|refseq:NP_001307540.1|ensembl:ENST00000330459(transcript)|ensembl:ENST00000537025(transcript)|ensembl:ENST00000579754(transcript)|ensembl:ENST00000584026(transcript)|ensembl:ENST00000677086(transcript)|ensembl:ENST00000679078(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52292|rcsb pdb:1EFX|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:3FEX|ensembl:ENSG00000182481(gene)|rcsb pdb:3FEY|rcsb pdb:3WPT|rcsb pdb:4E4V|rcsb pdb:4WV6|rcsb pdb:5H43|rcsb pdb:7N8J|reactome:R-HSA-111932|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-442729|reactome:R-HSA-5693548|reactome:R-HSA-9018519|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|ensembl:ENSP00000504685|dip:DIP-6205N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DFtAbvPxkzWJO/fRLPGxA6pEEJQ9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O00410	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09382	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048875|uniprotkb:B2R5E8|uniprotkb:Q9UDK5|ensembl:ENSP00000215909	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:leg1_human(display_long)|uniprotkb:Lectin galactoside-binding soluble 1(gene name synonym)|uniprotkb:Beta-galactoside-binding lectin L-14-I(gene name synonym)|uniprotkb:S-Lac lectin 1(gene name synonym)|uniprotkb:Galaptin(gene name synonym)|uniprotkb:14 kDa lectin(gene name synonym)|uniprotkb:HPL(gene name synonym)|uniprotkb:HBL(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM12(gene name synonym)|uniprotkb:LGALS1(gene name)|psi-mi:LGALS1(display_short)|uniprotkb:Lactose-binding lectin 1(gene name synonym)|uniprotkb:14 kDa laminin-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002296.1|ensembl:ENST00000215909(transcript)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030395"(lactose binding)|ensembl:ENSG00000100097(gene)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR044156|mint:P09382|rcsb pdb:1GZW|rcsb pdb:1W6M|rcsb pdb:1W6N|rcsb pdb:1W6O|rcsb pdb:1W6P|rcsb pdb:1W6Q|rcsb pdb:2KM2|rcsb pdb:2ZKN|rcsb pdb:3OY8|rcsb pdb:3OYW|rcsb pdb:3T2T|rcsb pdb:3W58|rcsb pdb:3W59|rcsb pdb:4Q1P|go:"GO:0031295"(T cell costimulation)|go:"GO:0034120"(positive regulation of erythrocyte aggregation)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043236"(laminin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0048678"(response to axon injury)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4Q1R|rcsb pdb:4Q26|rcsb pdb:4Q27|rcsb pdb:4Q2F|rcsb pdb:4XBL|rcsb pdb:4Y1U|rcsb pdb:4Y1V|rcsb pdb:4Y1X|rcsb pdb:4Y1Y|rcsb pdb:4Y1Z|rcsb pdb:4Y20|rcsb pdb:4Y22|rcsb pdb:4Y24|rcsb pdb:5MWT|rcsb pdb:5MWX|rcsb pdb:6B94|rcsb pdb:6F83|rcsb pdb:6M5Y|reactome:R-HSA-381426|reactome:R-HSA-8957275|dip:DIP-46153N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Sov3RfY2NOjdjuvdFlEd/vaNTMY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O15145	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351829|uniprotkb:O00554|ensembl:ENSP00000228825	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:arpc3_human(display_long)|uniprotkb:ARPC3(gene name)|psi-mi:ARPC3(display_short)|uniprotkb:ARC21(gene name synonym)|uniprotkb:Arp2/3 complex 21 kDa subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000111229(gene)|ensembl:ENST00000228825(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031941"(filamentous actin)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0061850"(growth cone leading edge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR007204(ARP2/3 complex, 21 kDa p21-Arc subunit)|interpro:IPR036753|mint:O15145|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|refseq:NP_001274151.1|refseq:NP_001265485.1|dip:DIP-33187N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u4h1270mPo3E3GBrEurYtpUYTQM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P42566	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-396684|uniprotkb:B2R8J7|uniprotkb:Q5SRH4|uniprotkb:D3DPJ2|intact:EBI-28966731|ensembl:ENSP00000360798	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:eps15_human(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001153441.1|refseq:NP_001972.1|ensembl:ENSP00000360798|ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P42566|rcsb pdb:1C07|rcsb pdb:1EH2|rcsb pdb:1F8H|rcsb pdb:1FF1|rcsb pdb:2IV9|rcsb pdb:2JXC|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4S0G|rcsb pdb:5AWT|rcsb pdb:5AWU|rcsb pdb:5JP2|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|dip:DIP-33064N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04075	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9ULV4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351384|uniprotkb:Q9NSK5|uniprotkb:B3KU12|ensembl:ENSP00000261401|ensembl:ENSP00000438341|intact:EBI-4404698|uniprotkb:A7MAP0|uniprotkb:A7MAP1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cor1c_human(display_long)|uniprotkb:CORO1C(gene name)|psi-mi:CORO1C(display_short)|uniprotkb:CRNN4(gene name synonym)|uniprotkb:Coronin-3(gene name synonym)|uniprotkb:hCRNN4(gene name synonym)|uniprotkb:CRN2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001263400.1|refseq:NP_055140.1|ensembl:ENSG00000110880(gene)|ensembl:ENST00000261401(transcript)|ensembl:ENST00000541050(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0090148"(membrane fission)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0016197"(endosomal transport)|go:"GO:0097750"(endosome membrane tubulation)|go:"GO:0140285"(endosome fission)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027333|interpro:IPR036322|mint:Q9ULV4|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|refseq:NP_001098707.1|refseq:XP_016874610.1|refseq:XP_016874611.1|refseq:XP_016874612.1|dip:DIP-33138N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Em/LQxjBk9n4tobk5ksyDfFSyeU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14839-2	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190797|ensembl:ENSP00000496634	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q14839-2(display_long)|uniprotkb:CHD4(gene name)|psi-mi:CHD4(display_short)|uniprotkb:ATP-dependent helicase CHD4(gene name synonym)|uniprotkb:Mi-2 autoantigen 218 kDa protein(gene name synonym)|uniprotkb:Mi2-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	intact:EBI-372916(isoform-parent)|ensembl:ENSG00000111642(gene)|ensembl:ENST00000645095(transcript)|uniprotkb:Q14839-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Msvk6YtgmdEXu9Kvatu7Qghc4BM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13612	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75955	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P06733	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P16401	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5327611|uniprotkb:Q14529|uniprotkb:Q3MJ42|ensembl:ENSP00000330074	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:h15_human(display_long)|uniprotkb:H1-5(gene name)|psi-mi:H1-5(display_short)|uniprotkb:H1F5(gene name synonym)|uniprotkb:HIST1H1B(gene name synonym)|uniprotkb:Histone H1a(gene name synonym)|uniprotkb:Histone H1b(gene name synonym)|uniprotkb:Histone H1s-3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005313.1|ensembl:ENSG00000184357(gene)|ensembl:ENST00000331442(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0071169"(establishment of protein localization to chromatin)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2FE2|rcsb pdb:2RHI|reactome:R-HSA-140342|reactome:R-HSA-2559584|go:"GO:0000792"(heterochromatin)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:b81Z7VA09Na0XXDfR0HtaZmq1g89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49721	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359335|uniprotkb:P31145|uniprotkb:Q9BWZ9|uniprotkb:D3DPS0|ensembl:ENSP00000362334	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb2_human(display_long)|uniprotkb:PSMB2(gene name)|psi-mi:PSMB2(display_short)|uniprotkb:Multicatalytic endopeptidase complex subunit C7-I(gene name synonym)|uniprotkb:Proteasome component C7-I(gene name synonym)|uniprotkb:Macropain subunit C7-I(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002785.1|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5GJR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-5689603|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000126067(gene)|ensembl:ENST00000373237(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035206|mint:P49721|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|dip:DIP-33848N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:PvXrk6RLayQ1zqmavn1cONfA9/A9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O76003	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374781|uniprotkb:Q96CE0|uniprotkb:Q9P1B0|uniprotkb:Q9P1B1|uniprotkb:B3KMP7|uniprotkb:B3KMQ5|uniprotkb:Q5JV01|ensembl:ENSP00000330836|ensembl:ENSP00000357633|ensembl:ENSP00000435445|uniprotkb:D3DRG2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:glrx3_human(display_long)|uniprotkb:GLRX3(gene name)|psi-mi:GLRX3(display_short)|uniprotkb:Thioredoxin-like protein 2(gene name synonym)|uniprotkb:PKC-interacting cousin of thioredoxin(gene name synonym)|uniprotkb:PKC-theta-interacting protein(gene name synonym)|uniprotkb:PICOT(gene name synonym)|uniprotkb:HUSSY-22(orf name)|uniprotkb:TXNL2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108010(gene)|ensembl:ENST00000331244(transcript)|ensembl:ENST00000368644(transcript)|ensembl:ENST00000481034(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0097573"(glutathione oxidoreductase activity)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249|mint:O76003|rcsb pdb:2DIY|rcsb pdb:2WZ9|rcsb pdb:2YAN|rcsb pdb:3ZYW|reactome:R-HSA-917937|refseq:NP_001186797.1|refseq:NP_006532.2|dip:DIP-31306N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:iKUSt6zbNzzXSKvW+vXMq3hKsEM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q13200	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49591	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1053431|uniprotkb:Q5T5C8|uniprotkb:Q9NSE3|uniprotkb:B2R6Y9|ensembl:ENSP00000234677	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sysc_human(display_long)|uniprotkb:SARS1(gene name)|psi-mi:SARS1(display_short)|uniprotkb:SARS(gene name synonym)|uniprotkb:SERS(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_006504.2|ensembl:ENSG00000031698(gene)|ensembl:ENST00000234677(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:1904046"(negative regulation of vascular endothelial growth factor production)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR015866(Seryl-tRNA synthetase, class IIa, N-terminal)|interpro:IPR033729|interpro:IPR042103|rcsb pdb:3VBB|rcsb pdb:4L87|rcsb pdb:4RQE|rcsb pdb:4RQF|reactome:R-HSA-2408557|reactome:R-HSA-379716|dip:DIP-38215N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4+Ai/MIybmiKJyfa0C0bhnW/CG49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y3B4	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1046261|ensembl:ENSP00000233468|uniprotkb:Q53TM1	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sf3b6_human(display_long)|uniprotkb:SF3B6(gene name)|psi-mi:SF3B6(display_short)|uniprotkb:Pre-mRNA branch site protein p14(gene name synonym)|uniprotkb:SAP14(gene name synonym)|uniprotkb:SF3B14(gene name synonym)|uniprotkb:SF3B14A(gene name synonym)|uniprotkb:SF3b 14 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein, 14-kDa(gene name synonym)|uniprotkb:Splicing factor 3b, subunit 6, 14kDa(gene name synonym)|uniprotkb:CGI-110(orf name)|uniprotkb:HSPC175(orf name)|uniprotkb:HT006(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000233468(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000115128(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034150|interpro:IPR035979|mint:Q9Y3B4|rcsb pdb:2F9D|rcsb pdb:2F9J|rcsb pdb:2FHO|rcsb pdb:3LQV|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_057131.1|dip:DIP-44132N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:7mhaXkmVqjfJGPdX1UDM+kN4vNI9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14839-1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-5279755|ensembl:ENSP00000440542	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:q14839-1(display_long)|uniprotkb:CHD4(gene name)|psi-mi:CHD4(display_short)|uniprotkb:ATP-dependent helicase CHD4(gene name synonym)|uniprotkb:Mi-2 autoantigen 218 kDa protein(gene name synonym)|uniprotkb:Mi2-beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	intact:EBI-372916(isoform-parent)|ensembl:ENSG00000111642(gene)|ensembl:ENST00000544040(transcript)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:E9eHT/41SIFRiz54J81hvPQeHIE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08107	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P25705	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P46778	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350634|uniprotkb:Q16699|ensembl:ENSP00000346027|ensembl:ENSP00000351021|ensembl:ENSP00000370569|ensembl:ENSP00000370574	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl21_human(display_long)|uniprotkb:RPL21(gene name)|psi-mi:RPL21(display_short)|uniprotkb:Large ribosomal subunit protein eL21(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6LU8|refseq:NP_000973.2|ensembl:ENSG00000122026(gene)|ensembl:ENST00000272274(transcript)|ensembl:ENST00000311549(transcript)|ensembl:ENST00000319826(transcript)|ensembl:ENST00000326092(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001147(Ribosomal protein L21e)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:P46778|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6OLE|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UCth+WL9Oj1Y9I5m4i/9X0a5WHk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q06830	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9H0A0	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:E9PB61	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190851|ensembl:ENSP00000421592	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:e9pb61_human(display_long)|uniprotkb:ALYREF(gene name)|psi-mi:ALYREF(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000183684(gene)|ensembl:ENST00000505490(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR025715|interpro:IPR035979|go:"GO:0016607"(nuclear speck)|refseq:NP_005773.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:1TYm+flGafmObpUMr0SV5tuEDR49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P24752	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1051459|uniprotkb:B2R6H1|uniprotkb:G3XAB4|uniprotkb:Q96FG8|ensembl:ENSP00000265838	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:thil_human(display_long)|uniprotkb:Acetoacetyl-CoA thiolase(gene name synonym)|uniprotkb:T2(gene name synonym)|uniprotkb:ACAT1(gene name)|psi-mi:ACAT1(display_short)|uniprotkb:ACAT(gene name synonym)|uniprotkb:MAT(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000010.1|ensembl:ENSG00000075239(gene)|ensembl:ENST00000265838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007420"(brain development)|go:"GO:0009725"(response to hormone)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016453"(C-acetyltransferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0034435"(cholesterol esterification)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046356"(acetyl-CoA catabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072229"(metanephric proximal convoluted tubule development)|go:"GO:0120225"(coenzyme A binding)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1902860"(propionyl-CoA biosynthetic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|rcsb pdb:2F2S|rcsb pdb:2IB7|rcsb pdb:2IB8|rcsb pdb:2IB9|rcsb pdb:2IBU|rcsb pdb:2IBW|rcsb pdb:2IBY|reactome:R-HSA-70895|reactome:R-HSA-77108|reactome:R-HSA-77111	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:UYAY+kDdcJqx/hrDFoXH9rgtm/E9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60842	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-73449|uniprotkb:P04765|uniprotkb:Q5U018|uniprotkb:Q61516|uniprotkb:B2R6L8|uniprotkb:D3DTP9|uniprotkb:J3QLC4|ensembl:ENSP00000293831	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:if4a1_human(display_long)|uniprotkb:EIF4A1(gene name)|psi-mi:EIF4A1(display_short)|uniprotkb:EIF4A(gene name synonym)|uniprotkb:DDX2A(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001407.1|refseq:NP_001191439.1|dip:DIP-29755N|ensembl:ENSG00000161960(gene)|ensembl:ENST00000293831(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P60842|rcsb pdb:2G9N|rcsb pdb:2ZU6|rcsb pdb:3EIQ|rcsb pdb:5ZBZ|rcsb pdb:5ZC9|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:e+2gp47oHrpxFbrBFSM4qTf3r7E9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q86XP3	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722353|uniprotkb:A6NML1|uniprotkb:O75619|uniprotkb:Q68G51|uniprotkb:Q96BK1|uniprotkb:Q96HR7|uniprotkb:Q9Y3V8|uniprotkb:A8KA43|intact:EBI-2555393|ensembl:ENSP00000374574|ensembl:ENSP00000463561|ensembl:ENSP00000464050	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ddx42_human(display_long)|uniprotkb:DEAD box protein 42(gene name synonym)|uniprotkb:Splicing factor 3B-associated 125 kDa protein(gene name synonym)|uniprotkb:RNA helicase-related protein(gene name synonym)|uniprotkb:RNA helicase-like protein(gene name synonym)|uniprotkb:SF3b DEAD box protein(gene name synonym)|uniprotkb:DDX42(gene name)|psi-mi:DDX42(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_031398.2|refseq:NP_987095.1|refseq:XP_006721720.1|refseq:XP_016879600.1|ensembl:ENSG00000198231(gene)|ensembl:ENST00000389924(transcript)|ensembl:ENST00000578681(transcript)|ensembl:ENST00000583590(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q86XP3|reactome:R-HSA-72163|reactome:R-HSA-72165	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:3vZn92rr6cO8qSZJdyq1fguSc489606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P13645	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-465144|ensembl:ENSP00000269576|uniprotkb:Q14664|uniprotkb:Q8N175	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c10_human(display_long)|uniprotkb:KRT10(gene name)|psi-mi:KRT10(display_short)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:KPP(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000186395(gene)|ensembl:ENST00000269576(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P13645|rcsb pdb:3ASW|rcsb pdb:4F1Z|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6EC0|rcsb pdb:6UUI|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000412.3	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:z100yyq3b63P0ARy2lE2ELyJeik9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48643	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355710|uniprotkb:A8JZY8|ensembl:ENSP00000280326|uniprotkb:A8K2X8|uniprotkb:B4DYD8	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tcpe_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)|uniprotkb:CCTE(gene name synonym)|uniprotkb:KIAA0098(gene name synonym)|uniprotkb:CCT-epsilon(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036205.1|ensembl:ENSG00000150753(gene)|ensembl:ENST00000280326(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|refseq:NP_001293084.1|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P48643|rcsb pdb:5UYX|rcsb pdb:5UYZ|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR012718(T-complex protein 1, epsilon subunit)|dip:DIP-31181N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u7uFkOYrDKL0gGvC24p34tQHhcw9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60900	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357793|uniprotkb:P34062|uniprotkb:Q6IB60|uniprotkb:B2R7J9|uniprotkb:B4DQR4|uniprotkb:B4DXJ9|ensembl:ENSP00000261479	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psa6_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short)|uniprotkb:PROS27(gene name synonym)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)|uniprotkb:27 kDa prosomal protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002782.1|refseq:NP_001269162.1|refseq:NP_001269163.1|refseq:XP_016876957.1|refseq:NP_001269161.1|ensembl:ENSG00000100902(gene)|ensembl:ENST00000261479(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0035639"(purine ribonucleoside triphosphate binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|mint:P60900|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29367N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43242	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9HB71	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09429	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-389432|uniprotkb:Q6IBE1|uniprotkb:A5D8W9|uniprotkb:Q14321|uniprotkb:Q5T7C3|ensembl:ENSP00000343040|ensembl:ENSP00000345347|ensembl:ENSP00000382417|ensembl:ENSP00000384678	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hmgb1_human(display_long)|uniprotkb:HMGB1(gene name)|psi-mi:HMGB1(display_short)|uniprotkb:HMG1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002119.1|refseq:NP_001300821.1|refseq:NP_001300822.1|ensembl:ENSG00000189403(gene)|ensembl:ENST00000339872(transcript)|ensembl:ENST00000341423(transcript)|ensembl:ENST00000399494(transcript)|ensembl:ENST00000405805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006265"(DNA topological change)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|interpro:IPR036910|mint:P09429|rcsb pdb:2LY4|rcsb pdb:2RTU|rcsb pdb:2YRQ|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|reactome:R-HSA-1236974|reactome:R-HSA-140342|reactome:R-HSA-166058|reactome:R-HSA-445989|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|dip:DIP-24195N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8iSPxYEMyB6thRmixTeyF5kfDbw9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P30153	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15102	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711522|uniprotkb:Q53X88|ensembl:ENSP00000262890|ensembl:ENSP00000444935	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pa1b3_human(display_long)|uniprotkb:PAFAH1B3(gene name)|psi-mi:PAFAH1B3(display_short)|uniprotkb:PAFAHG(gene name synonym)|uniprotkb:PAF acetylhydrolase 29 kDa subunit(gene name synonym)|uniprotkb:PAF-AH subunit gamma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0016042"(lipid catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|interpro:IPR013830(Esterase, SGNH hydrolase-type)|interpro:IPR036514|mint:Q15102|reactome:R-HSA-6811436|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0016020"(membrane)|ensembl:ENSG00000079462(gene)|ensembl:ENST00000262890(transcript)|ensembl:ENST00000538771(transcript)|go:"GO:0003847"(1-alkyl-2-acetylglycerophosphocholine esterase activity)|go:"GO:0005737"(cytoplasm)|refseq:NP_001139411.1|refseq:NP_001139412.1|refseq:NP_002564.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:yxVKkXAs2AmH+fZFUW+hZN889k89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P62829	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353303|uniprotkb:P23131|uniprotkb:Q3SWV7|uniprotkb:P24048|uniprotkb:Q29246|uniprotkb:Q6P5S1|ensembl:ENSP00000377865|ensembl:ENSP00000420311	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl23_human(display_long)|uniprotkb:RPL23(gene name)|psi-mi:RPL23(display_short)|uniprotkb:60S ribosomal protein L17(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL14(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|reactome:R-HSA-9010553|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|refseq:NP_000969.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62829|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|ensembl:ENSG00000125691(gene)|ensembl:ENST00000394332(transcript)|ensembl:ENST00000479035(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005730"(nucleolus)|dip:DIP-33156N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P48047	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:B1AKQ8	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190833|ensembl:ENSP00000416651	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:b1akq8_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000078369(gene)|ensembl:ENST00000437146(transcript)|go:"GO:0007165"(signal transduction)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR036322	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:BUB/7mf+WlDyk4rDXHXUrW9rKWE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P22234	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-712261|ensembl:ENSP00000264221|ensembl:ENSP00000421096|uniprotkb:E9PDH9|uniprotkb:Q68CQ5|intact:EBI-21352784	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:pur6_human(display_long)|uniprotkb:PAICS(gene name)|psi-mi:PAICS(display_short)|uniprotkb:ADE2(gene name synonym)|uniprotkb:AIRC(gene name synonym)|uniprotkb:PAIS(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000128050(gene)|ensembl:ENST00000264221(transcript)|ensembl:ENST00000512576(transcript)|go:"GO:0004639"(phosphoribosylaminoimidazolesuccinocarboxamide synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043727"(5-amino-4-imidazole carboxylate lyase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000031("1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase")|interpro:IPR018236|interpro:IPR028923|interpro:IPR033626|mint:P22234|rcsb pdb:2H31|rcsb pdb:6YB8|go:"GO:0004638"(phosphoribosylaminoimidazole carboxylase activity)|rcsb pdb:6YB9|reactome:R-HSA-73817|refseq:NP_001072992.1|refseq:NP_001072993.1|refseq:NP_006443.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:aR4Xj14ZQrPiY8cldw5o9AvjkAo9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q99798	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2932893|ensembl:ENSP00000216254|uniprotkb:O75809|uniprotkb:Q5JZ41|uniprotkb:Q6FHX0|uniprotkb:Q8TAQ6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:acon_human(display_long)|uniprotkb:ACO2(gene name)|psi-mi:ACO2(display_short)|uniprotkb:Citrate hydro-lyase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000100412(gene)|ensembl:ENST00000216254(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003994"(aconitate hydratase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0035900"(response to isolation stress)|go:"GO:0047780"(citrate dehydratase activity)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000573(Aconitase A/isopropylmalate dehydratase small subunit, swivel)|interpro:IPR001030(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha)|interpro:IPR006248(Aconitase, mitochondrial-like)|interpro:IPR015928(Aconitase/3-isopropylmalate dehydratase, swivel)|interpro:IPR015932(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2)|interpro:IPR018136|interpro:IPR036008|mint:Q99798|reactome:R-HSA-1268020|reactome:R-HSA-71403|interpro:IPR015931(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomains 1 and 3)|refseq:NP_001089.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:QpDlGJHSwqfCktMlwYXKTonXftA9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P27105	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O75489	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408	-	-	crc64:C058D62779BEF17B	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P04818	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-6190719|ensembl:ENSP00000315644|uniprotkb:Q8WYK3|uniprotkb:Q8WYK4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tysy_human(display_long)|uniprotkb:TYMS(gene name)|psi-mi:TYMS(display_short)|uniprotkb:TS(gene name synonym)|uniprotkb:OK/SW-cl.29(orf name)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000176890(gene)|ensembl:ENST00000323274(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0005542"(folic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0006235"(dTTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0019860"(uracil metabolic process)|go:"GO:0032259"(methylation)|go:"GO:0032570"(response to progesterone)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046683"(response to organophosphorus)|go:"GO:0048589"(developmental growth)|go:"GO:0051216"(cartilage development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051593"(response to folic acid)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|interpro:IPR023451|interpro:IPR036926|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019048"(modulation by virus of host process)|rcsb pdb:1HVY|rcsb pdb:4O1U|rcsb pdb:4O1X|rcsb pdb:4UP1|rcsb pdb:5HS3|rcsb pdb:5WRN|rcsb pdb:5X4W|rcsb pdb:5X4X|rcsb pdb:5X4Y|rcsb pdb:5X5A|rcsb pdb:4KPW|rcsb pdb:5X5D|rcsb pdb:5X5Q|rcsb pdb:5X66|rcsb pdb:5X67|rcsb pdb:5X69|rcsb pdb:6OJU|rcsb pdb:6OJV|rcsb pdb:6PF3|rcsb pdb:6PF4|rcsb pdb:6PF5|rcsb pdb:6PF6|rcsb pdb:6QXG|rcsb pdb:6QXH|rcsb pdb:6QYQ|rcsb pdb:6R2E|rcsb pdb:6ZXO|reactome:R-HSA-499943|reactome:R-HSA-69205|rcsb pdb:1HW4|rcsb pdb:1HZW|rcsb pdb:1I00|rcsb pdb:1JU6|rcsb pdb:1JUJ|rcsb pdb:1YPV|rcsb pdb:2ONB|rcsb pdb:2RD8|rcsb pdb:2RDA|rcsb pdb:3EAW|rcsb pdb:3EBU|rcsb pdb:3ED7|rcsb pdb:3EDW|rcsb pdb:3EF9|rcsb pdb:3EGY|rcsb pdb:3EHI|rcsb pdb:3EJL|rcsb pdb:3GG5|rcsb pdb:3GH0|rcsb pdb:3GH2|rcsb pdb:3H9K|rcsb pdb:3HB8|rcsb pdb:3N5E|rcsb pdb:3N5G|rcsb pdb:3OB7|rcsb pdb:4E28|rcsb pdb:4FGT|rcsb pdb:1HW3|rcsb pdb:4G2O|rcsb pdb:4G6W|rcsb pdb:4GD7|rcsb pdb:4GYH|rcsb pdb:4H1I|rcsb pdb:4JEF|go:"GO:0009636"(response to toxic substance)|go:"GO:0007568"(aging)|refseq:NP_001062.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:9GWaP/MRO1tyHPXsZ+axd6j8lqM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P31483	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P99999	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5SRE5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1049404|uniprotkb:Q14675|uniprotkb:Q2TA87|uniprotkb:Q7Z3K8|uniprotkb:Q8IWF1|intact:EBI-2555229|ensembl:ENSP00000361658	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nu188_human(display_long)|uniprotkb:NUP188(gene name)|psi-mi:NUP188(display_short)|uniprotkb:KIAA0169(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056169.1|ensembl:ENSG00000095319(gene)|ensembl:ENST00000372577(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018864|interpro:IPR044840|mint:Q5SRE5|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:eoj+tg9RAVKcVlT9ku1ozXCa3u89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14744	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-351098|uniprotkb:Q6IBR1|uniprotkb:A8MZ91|uniprotkb:Q9UKH1|uniprotkb:B5BU10|uniprotkb:D3DS33|ensembl:ENSP00000319169|uniprotkb:A8MTP3|uniprotkb:B4DX49|uniprotkb:B4DY30|uniprotkb:E2QRE7	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:anm5_human(display_long)|uniprotkb:PRMT5(gene name)|psi-mi:PRMT5(display_short)|uniprotkb:IBP72(gene name synonym)|uniprotkb:JBP1(gene name synonym)|uniprotkb:HRMT1L5(gene name synonym)|uniprotkb:Shk1 kinase-binding protein 1 homolog(gene name synonym)|uniprotkb:Jak-binding protein 1(gene name synonym)|uniprotkb:72 kDa ICln-binding protein(gene name synonym)|uniprotkb:SKB1(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001034708.1|refseq:NP_006100.2|refseq:NP_001269882.1|refseq:NP_001269884.1|refseq:NP_001269885.1|ensembl:ENSG00000100462(gene)|ensembl:ENST00000324366(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000785"(chromatin)|go:"GO:0002039"(p53 binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034709"(methylosome)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035243"(protein-arginine omega-N symmetric methyltransferase activity)|go:"GO:0035246"(peptidyl-arginine N-methylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0097421"(liver regeneration)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR007857(Skb1 methyltransferase)|interpro:IPR025799|interpro:IPR029063|interpro:IPR035075|interpro:IPR035247|interpro:IPR035248|mint:O14744|rcsb pdb:4GQB|rcsb pdb:4X60|rcsb pdb:4X61|rcsb pdb:4X63|rcsb pdb:5C9Z|rcsb pdb:5EMJ|rcsb pdb:5EMK|rcsb pdb:5EML|rcsb pdb:5EMM|rcsb pdb:5FA5|rcsb pdb:6CKC|rcsb pdb:6K1S|rcsb pdb:6RLL|rcsb pdb:6RLQ|rcsb pdb:6UGH|rcsb pdb:6UXX|rcsb pdb:6UXY|rcsb pdb:6V0N|rcsb pdb:6V0O|rcsb pdb:6V0P|rcsb pdb:7KIB|rcsb pdb:7KIC|rcsb pdb:7KID|rcsb pdb:7L1G|rcsb pdb:7M05|reactome:R-HSA-191859|reactome:R-HSA-3214858|reactome:R-HSA-6804760|go:"GO:1904992"(positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway)|dip:DIP-33172N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:EwePjCDiU/fiuKOO+wnoYQ8I57I9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P61981	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P53680	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297662|ensembl:ENSP00000263270|uniprotkb:O75977|uniprotkb:Q6PK67|uniprotkb:B2R4Z4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2s1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit sigma(gene name synonym)|uniprotkb:AP2S1(gene name)|psi-mi:AP2S1(display_short)|uniprotkb:Sigma2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 17 kDa protein(gene name synonym)|uniprotkb:HA2 17 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP17(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP17(gene name synonym)|uniprotkb:AP17(gene name synonym)|uniprotkb:CLAPS2(gene name synonym)|uniprotkb:Clathrin assembly protein 2 sigma small chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit sigma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000042753(gene)|ensembl:ENST00000263270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR027156|rcsb pdb:6URI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004060.2|refseq:NP_067586.1|refseq:NP_001288005.1|refseq:NP_001288007.1|refseq:NP_001288010.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AJxHeeoCpwPxjsRcAQkiAGaC9k09606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O94979	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1767898|uniprotkb:Q17RR5|uniprotkb:Q5H9P6|uniprotkb:Q5XG74|uniprotkb:Q659G7|uniprotkb:Q6ZU90|uniprotkb:Q7LCX9|uniprotkb:Q86TJ0|uniprotkb:Q8IZH4|uniprotkb:Q9P048|uniprotkb:Q9P0A6|uniprotkb:Q9UM05|uniprotkb:Q9UM06|uniprotkb:B7ZKZ7|uniprotkb:B7ZL00|uniprotkb:B4DIW6|uniprotkb:H7C2W3|ensembl:ENSP00000347329|ensembl:ENSP00000378721|ensembl:ENSP00000400926	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:sc31a_human(display_long)|uniprotkb:SEC31A(gene name)|psi-mi:SEC31A(display_short)|uniprotkb:KIAA0905(gene name synonym)|uniprotkb:SEC31L1(gene name synonym)|uniprotkb:HSPC275(orf name)|uniprotkb:HSPC334(orf name)|uniprotkb:SEC31-related protein A(gene name synonym)|uniprotkb:SEC31-like protein 1(gene name synonym)|uniprotkb:ABP125(gene name synonym)|uniprotkb:ABP130(gene name synonym)|uniprotkb:Web1-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001070674.1|refseq:NP_001070675.1|refseq:NP_001070676.1|refseq:NP_057295.2|refseq:NP_001305048.1|refseq:NP_001305049.1|refseq:NP_001287673.1|refseq:NP_001287674.1|refseq:NP_001177978.1|dip:DIP-40438N|ensembl:ENSG00000138674(gene)|ensembl:ENST00000355196(transcript)|ensembl:ENST00000395310(transcript)|ensembl:ENST00000448323(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024298|interpro:IPR036322|interpro:IPR040251|mint:O94979|rcsb pdb:3WXA|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-381038|reactome:R-HSA-983170	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:MvtQi/4RmQ0siNtNoYH6k1rPv1Y9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P40429	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-720205|uniprotkb:A8K505|ensembl:ENSP00000375730	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl13a_human(display_long)|uniprotkb:23 kDa highly basic protein(gene name synonym)|uniprotkb:RPL13A(gene name)|psi-mi:RPL13A(display_short)|uniprotkb:Large ribosomal subunit protein uL13(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_036555.1|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|rcsb pdb:6OLF|ensembl:ENSG00000142541(gene)|ensembl:ENST00000391857(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1901194"(negative regulation of formation of translation preinitiation complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005755(Ribosomal protein L13, eukaryotic/archaeal)|interpro:IPR005822(Ribosomal protein L13)|interpro:IPR023563|interpro:IPR036899|mint:P40429|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|refseq:NP_001257420.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:pcKDTEBZXxtm1MAH+4nv0p3PqFs9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49915	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1050289|uniprotkb:A8K639|uniprotkb:B4DXV7|uniprotkb:F8W720|ensembl:ENSP00000419851	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:guaa_human(display_long)|uniprotkb:GMP synthetase(gene name synonym)|uniprotkb:Glutamine amidotransferase(gene name synonym)|uniprotkb:GMPS(gene name)|psi-mi:GMPS(display_short)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_003866.1|ensembl:ENSG00000163655(gene)|ensembl:ENST00000496455(transcript)|go:"GO:0003921"(GMP synthase activity)|go:"GO:0003922"("GMP synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0016462"(pyrophosphatase activity)|interpro:IPR001674(GMP synthase, C-terminal)|interpro:IPR004739(GMP synthase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017926|interpro:IPR022310|interpro:IPR025777|interpro:IPR029062|mint:P49915|rcsb pdb:2VPI|rcsb pdb:2VXO|reactome:R-HSA-73817	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LYs65bPoqjVG/ZxA6v+yJo3HsLI9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q14160	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-357345|uniprotkb:Q6P496|uniprotkb:Q7Z5D1|uniprotkb:Q8WWV8|uniprotkb:Q96C69|uniprotkb:Q96GG1|ensembl:ENSP00000322938|ensembl:ENSP00000349486|ensembl:ENSP00000366756	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:scrib_human(display_long)|uniprotkb:SCRIB(gene name)|psi-mi:SCRIB(display_short)|uniprotkb:CRIB1(gene name synonym)|uniprotkb:KIAA0147(gene name synonym)|uniprotkb:LAP4(gene name synonym)|uniprotkb:SCRB1(gene name synonym)|uniprotkb:VARTUL(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_056171.3|refseq:NP_874365.3|dip:DIP-31259N|ensembl:ENSG00000180900(gene)|ensembl:ENST00000320476(transcript)|ensembl:ENST00000356994(transcript)|ensembl:ENST00000377533(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q14160|rcsb pdb:1UJU|rcsb pdb:1WHA|rcsb pdb:1X5Q|rcsb pdb:2W4F|rcsb pdb:4WYT|rcsb pdb:4WYU|rcsb pdb:5VWC|rcsb pdb:5VWI|rcsb pdb:5VWK|rcsb pdb:6EEY|rcsb pdb:6ESP|rcsb pdb:6MS1|rcsb pdb:6MTU|rcsb pdb:6MTV|rcsb pdb:6MYE|rcsb pdb:6MYF|rcsb pdb:6XA6|rcsb pdb:6XA7|rcsb pdb:6XA8|rcsb pdb:7JO7|reactome:R-HSA-4608870|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:y4lIQ2NivmndHYd/JXSKvU2jv+w9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P08243	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-722989|uniprotkb:P08184|uniprotkb:Q15666|uniprotkb:Q549T9|uniprotkb:Q96HD0|ensembl:ENSP00000175506|ensembl:ENSP00000377845|ensembl:ENSP00000377846|uniprotkb:A4D1I8|uniprotkb:D6W5R3|uniprotkb:B4DXZ1|uniprotkb:B7ZAA9|uniprotkb:E9PCI3|uniprotkb:E9PCX6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:asns_human(display_long)|uniprotkb:Glutamine-dependent asparagine synthetase(gene name synonym)|uniprotkb:Cell cycle control protein TS11(gene name synonym)|uniprotkb:ASNS(gene name)|psi-mi:ASNS(display_short)|uniprotkb:TS11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001171546.1|refseq:NP_001171547.1|refseq:NP_001171548.1|refseq:NP_001664.3|refseq:NP_597680.2|refseq:NP_899199.2|ensembl:ENSG00000070669(gene)|ensembl:ENST00000175506(transcript)|ensembl:ENST00000394308(transcript)|ensembl:ENST00000394309(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004066"("asparagine synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006529"(asparagine biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032354"(response to follicle-stimulating hormone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0070981"(L-asparagine biosynthetic process)|interpro:IPR001962(Asparagine synthase)|interpro:IPR006426(Asparagine synthase, glutamine-hydrolyzing)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017932|interpro:IPR029055|interpro:IPR033738|rcsb pdb:6GQ3|reactome:R-HSA-380994|reactome:R-HSA-8963693|reactome:R-HSA-9633012|reactome:R-HSA-9648895	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:McR8Ve0DzWhe3JWMYLsCRChiBaY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P36542	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O14980	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P49736	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P60660	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-300817|uniprotkb:P16475|uniprotkb:P24572|uniprotkb:P24573|uniprotkb:Q12790|ensembl:ENSP00000446955|ensembl:ENSP00000448101|uniprotkb:Q6IAZ0|uniprotkb:Q6IPY5|uniprotkb:Q561V9	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myl6_human(display_long)|uniprotkb:MYL6(gene name)|psi-mi:MYL6(display_short)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6(gene name synonym)|uniprotkb:Myosin light chain alkali 3(gene name synonym)|uniprotkb:Myosin light chain 3(gene name synonym)|uniprotkb:17 kDa myosin light chain(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000092841(gene)|ensembl:ENST00000548293(transcript)|ensembl:ENST00000550697(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|mint:P60660|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:NP_066299.2|refseq:NP_524147.2	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:LhE3NUqcuHlOla13C0vjnFZfzy89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q8TEM1	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-372826|uniprotkb:A6NN56|uniprotkb:O94980|uniprotkb:Q6NXG6|uniprotkb:Q8NBJ1|uniprotkb:Q9H6C8|uniprotkb:Q9UFP3|ensembl:ENSP00000254508	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:po210_human(display_long)|uniprotkb:KIAA0906(gene name synonym)|uniprotkb:NUP210(gene name)|psi-mi:NUP210(display_short)|uniprotkb:PSEC0245(orf name)|uniprotkb:Nuclear envelope pore membrane protein POM 210(gene name synonym)|uniprotkb:Pore membrane protein of 210 kDa(gene name synonym)|uniprotkb:Nucleoporin Nup210(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	reactome:R-HSA-9610379|refseq:NP_079199.2|ensembl:ENSG00000132182(gene)|ensembl:ENST00000254508(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003343(Bacterial Ig-like, group 2)|interpro:IPR008964(Invasin/intimin cell-adhesion)|mint:Q8TEM1|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:udIemFThWYk0VC21Ml4EDDQWXlg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P28072	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q5SSJ5	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-2880687|ensembl:ENSP00000312625|ensembl:ENSP00000403039|uniprotkb:Q5SWC6|uniprotkb:Q6PIM9|uniprotkb:B3KMZ8|uniprotkb:A8K5D7|uniprotkb:Q8NDF0|uniprotkb:Q05BI0|uniprotkb:B4E210|uniprotkb:A6NI71|uniprotkb:Q9UHY0|uniprotkb:Q5SSJ6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:hp1b3_human(display_long)|uniprotkb:HP1BP3(gene name)|psi-mi:HP1BP3(display_short)|uniprotkb:Protein HP1-BP74(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000127483(gene)|ensembl:ENST00000312239(transcript)|ensembl:ENST00000438032(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097298"(regulation of nucleus size)|interpro:IPR005818(Histone H1/H5)|interpro:IPR033061|interpro:IPR036388|interpro:IPR036390|mint:Q5SSJ5|rcsb pdb:2RQP|go:"GO:0005694"(chromosome)|refseq:XP_016856882.1|refseq:XP_016856883.1|refseq:XP_011539834.1|refseq:XP_011539835.1|refseq:XP_011539836.1|refseq:NP_057371.2|refseq:XP_005245932.1|refseq:XP_005245933.1|refseq:XP_005245934.1|refseq:XP_005245935.1|refseq:XP_005245936.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:kLFithZZv+Qn9YLElEnX81awKDw9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q9Y230	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63010	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P09211	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-353467|uniprotkb:O00460|uniprotkb:Q15690|ensembl:ENSP00000381607|uniprotkb:Q5TZY3	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:gstp1_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short)|uniprotkb:GST3(gene name synonym)|uniprotkb:FAEES3(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:GSTP1-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_000843.1|ensembl:ENSG00000084207(gene)|go:"GO:0000302"(response to reactive oxygen species)|ensembl:ENST00000398606(transcript)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0035732"(nitric oxide storage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P09211|rcsb pdb:10GS|rcsb pdb:11GS|rcsb pdb:12GS|rcsb pdb:13GS|rcsb pdb:14GS|rcsb pdb:16GS|rcsb pdb:17GS|rcsb pdb:18GS|rcsb pdb:19GS|rcsb pdb:1AQV|rcsb pdb:1AQW|rcsb pdb:1AQX|rcsb pdb:1EOG|rcsb pdb:1EOH|rcsb pdb:1GSS|rcsb pdb:1KBN|rcsb pdb:1LBK|rcsb pdb:1MD3|rcsb pdb:1MD4|rcsb pdb:1PGT|rcsb pdb:1PX6|rcsb pdb:1PX7|rcsb pdb:1ZGN|rcsb pdb:20GS|rcsb pdb:22GS|rcsb pdb:2A2R|rcsb pdb:2A2S|rcsb pdb:2GSS|rcsb pdb:2J9H|rcsb pdb:2PGT|rcsb pdb:3CSH|rcsb pdb:3CSI|rcsb pdb:3CSJ|rcsb pdb:3DD3|rcsb pdb:3DGQ|rcsb pdb:3GSS|rcsb pdb:3GUS|rcsb pdb:3HJM|rcsb pdb:3HJO|rcsb pdb:3HKR|rcsb pdb:3IE3|rcsb pdb:3KM6|rcsb pdb:3KMN|rcsb pdb:3KMO|rcsb pdb:3N9J|rcsb pdb:3PGT|rcsb pdb:4GSS|rcsb pdb:4PGT|rcsb pdb:5DAK|rcsb pdb:5DAL|rcsb pdb:5DCG|rcsb pdb:5DDL|rcsb pdb:5DJL|rcsb pdb:5DJM|rcsb pdb:5GSS|rcsb pdb:5J41|rcsb pdb:5JCW|rcsb pdb:5L6X|rcsb pdb:5X79|rcsb pdb:6AP9|rcsb pdb:6GSS|rcsb pdb:6LLX|rcsb pdb:6Y1E|rcsb pdb:7GSS|rcsb pdb:8GSS|rcsb pdb:9GSS|reactome:R-HSA-156590|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:JxqbNusNIvkTg3Cq+7pmygP/EIA9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P50914	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-356746|uniprotkb:Q45RF0|uniprotkb:Q53G20|uniprotkb:Q8TBD5|uniprotkb:Q8WUT0|uniprotkb:Q92579|uniprotkb:Q96GR0|uniprotkb:Q9BSB8|uniprotkb:Q9BW65|uniprotkb:Q9BYF6|ensembl:ENSP00000345156|ensembl:ENSP00000379506	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rl14_human(display_long)|uniprotkb:RPL14(gene name)|psi-mi:RPL14(display_short)|uniprotkb:CAG-ISL 7(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL14(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001030168.1|refseq:NP_003964.3|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002784(Ribosomal protein L14)|interpro:IPR008991(Translation protein SH3-like)|ensembl:ENSG00000188846(gene)|ensembl:ENST00000338970(transcript)|ensembl:ENST00000396203(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041985|mint:P50914|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|interpro:IPR039660|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y2L	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:AjaguD5hgHtcBbJq5QfuG6XdTcE9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P63000	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:Q15149	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-297903|intact:EBI-1103289|intact:EBI-1103265|intact:EBI-1055056|uniprotkb:Q15148|uniprotkb:Q16640|ensembl:ENSP00000323856|uniprotkb:Q6S376|intact:EBI-28976159|uniprotkb:Q6S380|intact:EBI-1103313|uniprotkb:Q6S377|uniprotkb:Q6S378|uniprotkb:Q6S379|intact:EBI-1103301|intact:EBI-1103253|uniprotkb:Q6S381|uniprotkb:Q6S382|uniprotkb:Q6S383|intact:EBI-2825763	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:plec_human(display_long)|uniprotkb:PLEC(gene name)|psi-mi:PLEC(display_short)|uniprotkb:Hemidesmosomal protein 1(gene name synonym)|uniprotkb:PLEC1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000178209(gene)|ensembl:ENST00000322810(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0120193"(tight junction organization)|go:"GO:2000689"(actomyosin contractile ring assembly actin filament organization)|go:"GO:2000983"(regulation of ATP citrate synthase activity)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR005326(Plectin/S10, N-terminal)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006997"(nucleus organization)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016569"(obsolete covalent chromatin modification)|go:"GO:0019226"(transmission of nerve impulse)|interpro:IPR030269|interpro:IPR035915|interpro:IPR018159|interpro:IPR036388|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q15149|rcsb pdb:1MB8|rcsb pdb:2N03|rcsb pdb:2ODU|rcsb pdb:2ODV|rcsb pdb:3F7P|rcsb pdb:3PDY|rcsb pdb:3PE0|rcsb pdb:4GDO|rcsb pdb:4Q58|rcsb pdb:4Q59|rcsb pdb:5J1F|rcsb pdb:5J1G|rcsb pdb:5J1H|rcsb pdb:5J1I|reactome:R-HSA-2022090|reactome:R-HSA-264870|reactome:R-HSA-446107|ensembl:ENST00000436759|ensembl:ENSP00000388180|ensembl:ENST00000527096|ensembl:ENSP00000434583|ensembl:ENSP00000323856|ensembl:ENST00000345136|ensembl:ENSP00000344848|ensembl:ENST00000354589|ensembl:ENSP00000346602|ensembl:ENST00000354958|ensembl:ENSP00000347044|ensembl:ENST00000356346|ensembl:ENSP00000348702|ensembl:ENST00000357649|ensembl:ENSP00000350277|ensembl:ENST00000398774|ensembl:ENSP00000381756|refseq:NP_000436.2|refseq:NP_958780.1|refseq:NP_958781.1|refseq:NP_958782.1|refseq:NP_958783.1|refseq:NP_958784.1|refseq:NP_958785.1|refseq:NP_958786.1	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zbctDAOOCaJUx3WBdp85v7SI0sI9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43143	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1237044|uniprotkb:Q9NQT7|ensembl:ENSP00000336741	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:dhx15_human(display_long)|uniprotkb:DHX15(gene name)|psi-mi:DHX15(display_short)|uniprotkb:DBP1(gene name synonym)|uniprotkb:DDX15(gene name synonym)|uniprotkb:DEAH box protein 15(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #46(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001349.2|dip:DIP-38211N|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR044756|mint:O43143|rcsb pdb:5XDR|rcsb pdb:6ID1|rcsb pdb:6SH6|rcsb pdb:6SH7|reactome:R-HSA-72163|ensembl:ENSG00000109606(gene)|ensembl:ENST00000336812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0043279"(response to alkaloid)	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:rOkQ5RG/3gc1/0Qcn5ANS6ImepY9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:O43324	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-1048486|uniprotkb:Q5THS2|ensembl:ENSP00000369038|uniprotkb:C9JLK5	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:mca3_human(display_long)|uniprotkb:Multisynthase complex auxiliary component p18(gene name synonym)|uniprotkb:Elongation factor p18(gene name synonym)|uniprotkb:EEF1E1(gene name)|psi-mi:EEF1E1(display_short)|uniprotkb:P18(gene name synonym)|uniprotkb:AIMP3(gene name synonym)|uniprotkb:Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_001129122.1|refseq:NP_004271.1|ensembl:ENSG00000124802(gene)|ensembl:ENST00000379715(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036282|interpro:IPR042450|mint:O43324|rcsb pdb:2UZ8|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5BMU|rcsb pdb:5Y6L|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-50581N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:4AuJouC9q6uAH/4EH8SKSPHyEZU9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	uniprotkb:P35579	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	-	-	-	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192353	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00792850|uniparc:UPI0000E5ADE6	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:zyx-like(display_short)|psi-mi:EBI-6192353(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:SIOzC91N2HMw+7voQITeRCePuC89606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192338	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	ipi:IPI00736402|uniparc:UPI00006C1D56	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:nog1-like(display_short)|psi-mi:EBI-6192338(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:06I44nYqpH+AFVArCyEzNHAM7zM9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P19320	intact:EBI-6192398	intact:EBI-6189824|ensembl:ENSP00000294728|uniprotkb:B4DKS4|uniprotkb:E9PDD1|uniprotkb:A8K6R7|uniprotkb:Q6NUP8	uniparc:UPI0000073D6C|ipi:IPI00383111	psi-mi:vcam1_human(display_long)|uniprotkb:VCAM1(gene name)|psi-mi:VCAM1(display_short)|uniprotkb:INCAM-100(gene name synonym)	psi-mi:k1c10-like(display_short)|psi-mi:EBI-6192398(display_long)	psi-mi:"MI:0030"(cross-linking study)	Byron et al. (2012)	imex:IM-17358|pubmed:22623428	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6189921|imex:IM-17358-3|pride:19284|pride:19285	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162692(gene)|ensembl:ENST00000294728(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002102"(podosome)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035094"(response to nicotine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005615"(extracellular space)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060384"(innervation)|go:"GO:0060945"(cardiac neuron differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071065"(alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003989(Vascular cell adhesion molecule-1)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P19320|rcsb pdb:1IJ9|rcsb pdb:1VCA|rcsb pdb:1VSC|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-877300|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001069.1|refseq:NP_001186763.1|refseq:NP_542413.1	-	-	-	no-uniprot-update:|caution:The sequence given comes from the UniParc accession and it could be not 100% accurate. The protein was identified by the authors with an IPI number, but no sequence could be retrieved for it.|comment:Probably contaminant.	figure legend:table S3|variable_condition:"These interaction were detected using a lysate of K562 cells transfected with the wild-type version (WT) of alpha-4 integrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/11	2020/01/07	rogid:ZgZa+cLeZ2PxFhdxPut2qd7QHVo9606	rogid:zhw8GDGRkP65Pnm5ZMbBSMlTsqc9606	intact-crc:BEC948258187320E|rigid:tY5k3BclVvUSHS/W+IOreZzsye4	false	fc-igg tag:c-c|mutation disrupting interaction:40-40	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)